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acetaminophen and Alcoholic Liver Diseases

acetaminophen has been researched along with Alcoholic Liver Diseases in 20 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
" The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity."3.67Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984)
" Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects."2.73The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. ( Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT, 2007)
"Therapeutic dosing of paracetamol administered for 10 days appears to elevate serum ALT in moderate drinkers, but does not produce clinically evident liver injury."2.73A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol. ( Bailey, JE; Bogdan, GM; Dart, RC; Green, JL; Heard, K, 2007)
"Acetaminophen was not administered until the alcohol had been eliminated."2.70Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial. ( Bogdan, GM; Casper, E; Dart, RC; Darton, L; Hill, RE; Kuffner, EK, 2001)
" The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite."2.37Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986)
" In addition, ibuprofen can be combined with acetaminophen without altering the pharmacokinetic profile."1.27Pharmacokinetics of ibuprofen. ( Albert, KS; Gernaat, CM, 1984)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19906 (30.00)18.7374
1990's3 (15.00)18.2507
2000's9 (45.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Laverty, HG1
Antoine, DJ1
Benson, C1
Chaponda, M1
Williams, D1
Kevin Park, B1
Bala, S1
Petrasek, J1
Mundkur, S1
Catalano, D1
Levin, I1
Ward, J1
Alao, H1
Kodys, K1
Szabo, G1
Wong, F1
Dart, RC4
Kuffner, E1
Kaplowitz, N1
Gonzalez, FJ1
Kuffner, EK2
Green, JL2
Bogdan, GM3
Knox, PC1
Palmer, RB1
Heard, K2
Slattery, JT1
Bailey, JE1
Worriax, JD1
Yates, JE1
Flake, D1
Saseen, JJ1
Albert, KS1
Gernaat, CM1
Pounder, DJ1
Heathcote, J1
Wanless, IR1
Tsutsumi, M2
Takada, A1
Wang, JS1
Ueshima, Y1
Takase, S1
Matsuda, Y1
Kawahara, H1
Prescott, LF1
Hill, RE1
Casper, E1
Darton, L1
Knochel, JP1
Andersson, TR1
Bell, H1
Seeff, LB1
Cuccherini, BA1
Zimmerman, HJ1
Adler, E1
Benjamin, SB1
Lesser, PB1
Vietti, MM1
Clark, WD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label, Randomized, 3-way Crossover Study to Evaluate the Pharmacokinetics of Investigational Product Ibuprofen Modified-Release Tablets 800 mg Compared to Ibuprofen Tablets 800 mg in Healthy Volunteers[NCT05329454]Phase 130 participants (Actual)Interventional2020-12-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for acetaminophen and Alcoholic Liver Diseases

ArticleYear
The potential of cytokines as safety biomarkers for drug-induced liver injury.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:10

    Topics: Acetaminophen; Anesthetics, Inhalation; Animals; Biomarkers; Chemical and Drug Induced Liver Injury;

2010
Liver and kidney diseases.
    Clinics in liver disease, 2002, Volume: 6, Issue:4

    Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G

2002
Liver biology and pathobiology.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:2 Suppl 1

    Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Diseases, Alc

2006
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome

2007
Clinical inquiries. Alcoholic liver disease: is acetaminophen safe?
    The Journal of family practice, 2007, Volume: 56, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea

2007
Hepatotoxicity: newer aspects of pathogenesis and treatment.
    The Gastroenterologist, 1995, Volume: 3, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages;

1995
Paracetamol, alcohol and the liver.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:4

    Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Central Nervous System Depressants; Ethanol; Hu

2000
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
    Annals of internal medicine, 1986, Volume: 104, Issue:3

    Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati

1986

Trials

3 trials available for acetaminophen and Alcoholic Liver Diseases

ArticleYear
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
    BMC medicine, 2007, May-30, Volume: 5

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspart

2007
A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol.
    Alimentary pharmacology & therapeutics, 2007, Jul-15, Volume: 26, Issue:2

    Topics: Acetaminophen; Adult; Alanine Transaminase; Alcohol Drinking; Analgesics, Non-Narcotic; Dose-Respons

2007
Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial.
    Archives of internal medicine, 2001, Oct-08, Volume: 161, Issue:18

    Topics: Acetaminophen; Adult; Aged; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dos

2001

Other Studies

9 other studies available for acetaminophen and Alcoholic Liver Diseases

ArticleYear
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cp

2012
Alcohol and acetaminophen hepatotoxicity.
    Archives of internal medicine, 2003, Jan-27, Volume: 163, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Live

2003
Pharmacokinetics of ibuprofen.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Acetaminophen; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Aspirin; Biological Availability; Ch

1984
Problems in the necropsy diagnosis of alcoholic liver disease.
    The American journal of forensic medicine and pathology, 1984, Volume: 5, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D

1984
Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease.
    Gastroenterology, 1994, Volume: 107, Issue:5

    Topics: Acetaminophen; Adult; Aged; Alcohol Drinking; Base Sequence; Chi-Square Distribution; Cytochrome P-4

1994
Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes.
    Alcoholism, clinical and experimental research, 1996, Volume: 20, Issue:1 Suppl

    Topics: Acetaminophen; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Ethanol; Genotype; Half-Life

1996
Does hypophosphatemia play a role in acute liver failure?
    Hepatology (Baltimore, Md.), 1989, Volume: 9, Issue:3

    Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Fructose; Hepatic Enc

1989
Plasma heparin cofactor II in alcoholic liver disease.
    Journal of hepatology, 1988, Volume: 7, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Antithrombins; Female; Glycoproteins; Heparin Cofacto

1988
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:1

    Topics: Acetaminophen; Autopsy; Bacterial Infections; Chemical and Drug Induced Liver Injury; Drug Synergism

1986