acetaminophen has been researched along with Alcoholic Liver Diseases in 20 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity." | 3.67 | Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984) |
| " Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects." | 2.73 | The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. ( Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT, 2007) |
| "Therapeutic dosing of paracetamol administered for 10 days appears to elevate serum ALT in moderate drinkers, but does not produce clinically evident liver injury." | 2.73 | A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol. ( Bailey, JE; Bogdan, GM; Dart, RC; Green, JL; Heard, K, 2007) |
| "Acetaminophen was not administered until the alcohol had been eliminated." | 2.70 | Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial. ( Bogdan, GM; Casper, E; Dart, RC; Darton, L; Hill, RE; Kuffner, EK, 2001) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| " In addition, ibuprofen can be combined with acetaminophen without altering the pharmacokinetic profile." | 1.27 | Pharmacokinetics of ibuprofen. ( Albert, KS; Gernaat, CM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Laverty, HG | 1 |
| Antoine, DJ | 1 |
| Benson, C | 1 |
| Chaponda, M | 1 |
| Williams, D | 1 |
| Kevin Park, B | 1 |
| Bala, S | 1 |
| Petrasek, J | 1 |
| Mundkur, S | 1 |
| Catalano, D | 1 |
| Levin, I | 1 |
| Ward, J | 1 |
| Alao, H | 1 |
| Kodys, K | 1 |
| Szabo, G | 1 |
| Wong, F | 1 |
| Dart, RC | 4 |
| Kuffner, E | 1 |
| Kaplowitz, N | 1 |
| Gonzalez, FJ | 1 |
| Kuffner, EK | 2 |
| Green, JL | 2 |
| Bogdan, GM | 3 |
| Knox, PC | 1 |
| Palmer, RB | 1 |
| Heard, K | 2 |
| Slattery, JT | 1 |
| Bailey, JE | 1 |
| Worriax, JD | 1 |
| Yates, JE | 1 |
| Flake, D | 1 |
| Saseen, JJ | 1 |
| Albert, KS | 1 |
| Gernaat, CM | 1 |
| Pounder, DJ | 1 |
| Heathcote, J | 1 |
| Wanless, IR | 1 |
| Tsutsumi, M | 2 |
| Takada, A | 1 |
| Wang, JS | 1 |
| Ueshima, Y | 1 |
| Takase, S | 1 |
| Matsuda, Y | 1 |
| Kawahara, H | 1 |
| Prescott, LF | 1 |
| Hill, RE | 1 |
| Casper, E | 1 |
| Darton, L | 1 |
| Knochel, JP | 1 |
| Andersson, TR | 1 |
| Bell, H | 1 |
| Seeff, LB | 1 |
| Cuccherini, BA | 1 |
| Zimmerman, HJ | 1 |
| Adler, E | 1 |
| Benjamin, SB | 1 |
| Lesser, PB | 1 |
| Vietti, MM | 1 |
| Clark, WD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Randomized, 3-way Crossover Study to Evaluate the Pharmacokinetics of Investigational Product Ibuprofen Modified-Release Tablets 800 mg Compared to Ibuprofen Tablets 800 mg in Healthy Volunteers[NCT05329454] | Phase 1 | 30 participants (Actual) | Interventional | 2020-12-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for acetaminophen and Alcoholic Liver Diseases
| Article | Year |
|---|---|
The potential of cytokines as safety biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Anesthetics, Inhalation; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; | 2010 |
Liver and kidney diseases.
Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G | 2002 |
Liver biology and pathobiology.
Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Diseases, Alc | 2006 |
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2007 |
Clinical inquiries. Alcoholic liver disease: is acetaminophen safe?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea | 2007 |
Hepatotoxicity: newer aspects of pathogenesis and treatment.
Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; | 1995 |
Paracetamol, alcohol and the liver.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Central Nervous System Depressants; Ethanol; Hu | 2000 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
3 trials available for acetaminophen and Alcoholic Liver Diseases
| Article | Year |
|---|---|
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspart | 2007 |
A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcohol Drinking; Analgesics, Non-Narcotic; Dose-Respons | 2007 |
Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Adult; Aged; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dos | 2001 |
9 other studies available for acetaminophen and Alcoholic Liver Diseases
| Article | Year |
|---|---|
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cp | 2012 |
Alcohol and acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Live | 2003 |
Pharmacokinetics of ibuprofen.
Topics: Acetaminophen; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Aspirin; Biological Availability; Ch | 1984 |
Problems in the necropsy diagnosis of alcoholic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D | 1984 |
Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease.
Topics: Acetaminophen; Adult; Aged; Alcohol Drinking; Base Sequence; Chi-Square Distribution; Cytochrome P-4 | 1994 |
Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes.
Topics: Acetaminophen; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Ethanol; Genotype; Half-Life | 1996 |
Does hypophosphatemia play a role in acute liver failure?
Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Fructose; Hepatic Enc | 1989 |
Plasma heparin cofactor II in alcoholic liver disease.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Antithrombins; Female; Glycoproteins; Heparin Cofacto | 1988 |
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
Topics: Acetaminophen; Autopsy; Bacterial Infections; Chemical and Drug Induced Liver Injury; Drug Synergism | 1986 |