acetaminophen has been researched along with Aging in 101 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, such as acetaminophen (APAP), are frequently taken during pregnancy, even in combination." | 7.91 | In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. ( Boizet-Bonhoure, B; Brun, C; de Massy, B; Déjardin, S; Ghettas, A; Keime, C; Marchive, C; Nguyen, AL; Ollivier, M; Philibert, P; Poulat, F; Pruvost, A; Rossitto, M, 2019) |
| "We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen." | 7.80 | The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. ( Cogger, VC; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, BE; Le Couteur, DG; Mach, J; McKenzie, C, 2014) |
| "These results suggest that acetaminophen may be useful for the treatment of age-associated hyperglycemia." | 7.75 | Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2. ( Blough, ER; Desai, DH; Gutta, AK; Kakarla, SK; Katta, A; Paturi, S; Rice, KM; Walker, EM; Wu, M, 2009) |
| "Our previous results indicated that glutathione (GSH) and/or cysteine (Cys) deficiency occurs in many aging tissues and also after acetaminophen (APAP) administration." | 7.70 | Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. ( Chen, TS; Lang, CA; Nagasawa, HT; Richie, JP, 2000) |
| "The effects of aging on selected drug-metabolizing enzyme activities, the pattern of phenol and bile salt sulfotransferase isoenzymes and the pharmacokinetics of acetaminophen were examined in male Fischer 344 rats at ages 5, 14 and 25 months." | 7.67 | Effect of aging on drug-metabolizing enzymes important in acetaminophen elimination. ( Franklin, MR; Galinsky, RE; Kane, RE, 1986) |
| "Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain." | 5.62 | Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. ( Alen, R; Boscá, L; Brea, R; Casado, M; Fuertes-Agudo, M; García-Monzón, C; Martín-Sanz, P; Rada, P; Valdecantos, P; Valverde, ÁM, 2021) |
| "Nonopioid analgesics, which include acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2)-specific inhibitors (coxibs), are frequently used for the relief of mild-to-moderate pain." | 4.83 | Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. ( Whelton, A, 2006) |
| "Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, such as acetaminophen (APAP), are frequently taken during pregnancy, even in combination." | 3.91 | In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. ( Boizet-Bonhoure, B; Brun, C; de Massy, B; Déjardin, S; Ghettas, A; Keime, C; Marchive, C; Nguyen, AL; Ollivier, M; Philibert, P; Poulat, F; Pruvost, A; Rossitto, M, 2019) |
| " Analgesics were coded as any pain medication, counts (total analgesics, number of opioids and nonopioids), equianalgesics (oral morphine equivalents, oral acetaminophen equivalents), and dose categories." | 3.91 | Analyzing Analgesic Medications in Community-Dwelling Older Adults. ( Farland, MZ; Horgas, AL; Marsiske, M; Snigurska, U, 2019) |
| "We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen." | 3.80 | The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. ( Cogger, VC; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, BE; Le Couteur, DG; Mach, J; McKenzie, C, 2014) |
| " Paracetamol (acetaminophen) is generally recommended as a first-choice analgesic in osteoarthritis pain." | 3.79 | Managing osteoarthritis pain in the older population. ( Cunningham, E; Passmore, P, 2013) |
| "To explore the key motivators behind selection of analgesics (nonsteroidal antiinflammatory drugs [NSAIDs], acetaminophen, and complementary medications [CMs]) by patients with osteoarthritis (OA)." | 3.77 | "It looks after me": how older patients make decisions about analgesics for osteoarthritis. ( Day, RO; Lipworth, WL; Milder, TY; Ritchie, JE; Williams, KM, 2011) |
| "Patients undergoing major surgery represent a good model for the study of the hepatic metabolism of acetaminophen (APAP) after surgery and for the evaluation of how the detoxification process is influenced by aging." | 3.77 | Acetaminophen metabolism after major surgery: a greater challenge with increasing age. ( Dubray, C; Papet, I; Pereira, B; Pickering, G; Pujos-Guillot, E; Schneider, E; Schoeffler, P; Simen, E, 2011) |
| "Aging is associated with impairments in the regulation of proteins thought to be important in controlling mRNA translation, and acetaminophen may be useful for the treatment of age-related muscle atrophy by reducing oxidative stress." | 3.76 | Acetaminophen improves protein translational signaling in aged skeletal muscle. ( Arvapalli, RK; Blough, ER; Fannin, J; Karkala, SK; Katta, A; Liu, H; Paturi, S; Rice, KM; Wang, Y; Wu, M, 2010) |
| " Here, we determine if acetaminophen is efficacious in decreasing age-related increases in cardiac reactive oxygen species (ROS) and apoptosis in aging Fischer 344 X Brown Norway rats." | 3.76 | Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat. ( Blough, ER; Fannin, JC; Kakarla, SK; Katta, A; Keshavarzian, S; Manzoor, K; Nalabotu, SK; Paturi, S; Rice, KM; Walker, EM; Wu, M, 2010) |
| "These results suggest that acetaminophen may be useful for the treatment of age-associated hyperglycemia." | 3.75 | Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2. ( Blough, ER; Desai, DH; Gutta, AK; Kakarla, SK; Katta, A; Paturi, S; Rice, KM; Walker, EM; Wu, M, 2009) |
| "Our previous results indicated that glutathione (GSH) and/or cysteine (Cys) deficiency occurs in many aging tissues and also after acetaminophen (APAP) administration." | 3.70 | Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. ( Chen, TS; Lang, CA; Nagasawa, HT; Richie, JP, 2000) |
| "The effects of aging on acetaminophen metabolism and elimination in male Fischer 344 rats were examined after intravenous injection of 300 mg/kg." | 3.67 | Influence of advanced age on the formation and elimination of acetaminophen metabolites by male rats. ( Corcoran, GB; Galinsky, RE, 1986) |
| " Based on the final model, dosing guidelines are proposed from preterm neonates to adolescents resulting in similar exposure across all age ranges." | 2.79 | Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults. ( Allegaert, K; Danhof, M; Knibbe, CA; Mathot, RA; Tibboel, D; van der Marel, CD; Wang, C, 2014) |
| " The dose-response relationship varied in the three systems (stomach, salivary glands and heart rate) studied." | 2.67 | Effect of intravenous atropine on gastric emptying, paracetamol absorption, salivary flow and heart rate in young and fit elderly volunteers. ( Bateman, DN; Rashid, MU, 1990) |
| "Sciatica is a debilitating condition affecting approximately 25 % of the population." | 2.53 | The Challenges of Treating Sciatica Pain in Older Adults. ( Ferreira, ML; McLachlan, A, 2016) |
| " Size is the primary covariate and although lean body weight is argued as a better measure than total body weight, the use of different fractions of fat mass to explain how pharmacokinetic parameters vary with body composition has been proposed." | 2.45 | Mechanistic basis of using body size and maturation to predict clearance in humans. ( Anderson, BJ; Holford, NH, 2009) |
| "Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain." | 1.62 | Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. ( Alen, R; Boscá, L; Brea, R; Casado, M; Fuertes-Agudo, M; García-Monzón, C; Martín-Sanz, P; Rada, P; Valdecantos, P; Valverde, ÁM, 2021) |
| "Physiological and drug-specific parameters need to be adjusted when extrapolating a pharmacokinetic (PK) model from adults to neonates, so as to reproduce the time profiles of the studied drug(s) consistent with clinical, in vivo data or in vitro cell line measurements." | 1.56 | Extrapolation for a pharmacokinetic model for acetaminophen from adults to neonates: A Latin Hypercube Sampling analysis. ( Ho, H; Zhang, E; Zhang, S, 2020) |
| " Despite old age and frailty being associated with extensive and long-term utilization of acetaminophen and a high prevalence of adverse drug reactions, there is limited information on the risks of toxicity from acetaminophen in old age and frailty." | 1.43 | Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. ( Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, AE; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ, 2016) |
| " In 19-month-old male offspring, epididymal sperm counts were lower than controls, and in ventral prostate an overrepresentation of findings related to hyperplasia was observed in exposed groups compared with controls, particularly in the group dosed with anti-androgens." | 1.40 | Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Isling, LK; Jacobsen, PR; Kortenkamp, A; Mandrup, KR; Taxvig, C; Vinggaard, AM, 2014) |
| "Acetaminophen treatment upregulates VEGF, PEDF and PACAP in brain endothelial cells exposed to oxidative stress." | 1.38 | Age-related decrease in cerebrovascular-derived neuroprotective proteins: effect of acetaminophen. ( Grammas, P; Martinez, J; Sanchez, A; Tripathy, D; Yin, X, 2012) |
| " Paracetamol clearance showed a statistically significant dependence on age group, whereas volume of distribution during elimination and elimination half-life were associated with age group and sex, respectively." | 1.37 | Pharmacokinetics of intravenous paracetamol in elderly patients. ( Aantaa, R; Kuusniemi, K; Liukas, A; Neuvonen, PJ; Niemi, M; Olkkola, KT; Virolainen, P, 2011) |
| "The RRs of prostate cancer comparing ever to never use were 0." | 1.33 | Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. ( Carter, HB; Corrada, MM; De Marzo, AM; Landis, PK; Metter, EJ; Pearson, JD; Platz, EA; Rohrmann, S; Watson, DJ, 2005) |
| " These data together with histopathological results, clearly showed that the inducible GSH system in weanling rat liver act as a safe guard against APAP toxicity." | 1.30 | Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity. ( Allameh, A; Vansoun, EY; Zarghi, A, 1997) |
| " These results will suggest that with repeated dosing of AAP special care must be taken in schistosomal patients since the elimination of AAP from plasma is remarkably reduced." | 1.29 | Acetaminophen plasma level after oral administration in liver cirrhotic patients suffering from schistosomal infection. ( el-Azab, G; Higashi, Y; Murakami, T; Yata, N; Youssef, MK, 1996) |
| "The bioavailability of paracetamol from suppositories was studied in 16 geriatric in-patients in stable clinical condition; 9 had significant amounts of feces in the rectum." | 1.28 | Absorption of paracetamol from suppositories in geriatric patients with fecal accumulation in the rectum. ( Hagen, IJ; Haram, EM; Laake, K, 1991) |
| "Acetaminophen bioactivation was quantified by production of the glutathione-derived cysteine and mercapturic acid conjugates of acetaminophen." | 1.28 | Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid. ( Kalabis, GM; Wells, PG, 1990) |
| " Despite the decreased clearance by these pathways, reduction in paracetamol dosage should not be necessary in the elderly." | 1.27 | Comparison of paracetamol metabolism in young adult and elderly males. ( Birkett, DJ; Miners, JO; Penhall, R; Robson, RA, 1988) |
| "Phenobarbital was slowly eliminated from the plasma at all ages and there was no indication of p-hydroxylated metabolite formation." | 1.27 | Drug disposition and biotransformation in the developing beagle dog. ( D'Ver, AS; Ecobichon, DJ; Ehrhart, W, 1988) |
| " On the basis of kinetics data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary." | 1.26 | Acetaminophen kinetics in the elderly. ( Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ, 1982) |
| " Absolute bioavailability of both oral dosage forms was significantly less then 100 per cent in all groups." | 1.26 | Age does not alter acetaminophen absorption. ( Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ, 1982) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic, but its disposition in human milk has not yet been reported." | 1.26 | Disposition of acetaminophen in milk, saliva, and plasma of lactating women. ( Berlin, CM; Ragni, M; Yaffe, SJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (28.71) | 18.7374 |
| 1990's | 23 (22.77) | 18.2507 |
| 2000's | 19 (18.81) | 29.6817 |
| 2010's | 28 (27.72) | 24.3611 |
| 2020's | 2 (1.98) | 2.80 |
| Authors | Studies |
|---|---|
| Rossitto, M | 1 |
| Ollivier, M | 1 |
| Déjardin, S | 1 |
| Pruvost, A | 1 |
| Brun, C | 1 |
| Marchive, C | 1 |
| Nguyen, AL | 1 |
| Ghettas, A | 1 |
| Keime, C | 1 |
| de Massy, B | 1 |
| Poulat, F | 1 |
| Philibert, P | 1 |
| Boizet-Bonhoure, B | 1 |
| Zhang, S | 1 |
| Zhang, E | 1 |
| Ho, H | 1 |
| Brea, R | 1 |
| Valdecantos, P | 1 |
| Rada, P | 1 |
| Alen, R | 1 |
| García-Monzón, C | 1 |
| Boscá, L | 1 |
| Fuertes-Agudo, M | 1 |
| Casado, M | 1 |
| Martín-Sanz, P | 1 |
| Valverde, ÁM | 1 |
| Horgas, AL | 1 |
| Snigurska, U | 1 |
| Farland, MZ | 1 |
| Marsiske, M | 1 |
| Mach, J | 2 |
| Huizer-Pajkos, A | 3 |
| Cogger, VC | 2 |
| McKenzie, C | 2 |
| Le Couteur, DG | 3 |
| Jones, BE | 1 |
| de Cabo, R | 3 |
| Hilmer, SN | 4 |
| Passmore, P | 1 |
| Cunningham, E | 1 |
| Isling, LK | 1 |
| Boberg, J | 1 |
| Jacobsen, PR | 1 |
| Mandrup, KR | 1 |
| Axelstad, M | 1 |
| Christiansen, S | 1 |
| Vinggaard, AM | 1 |
| Taxvig, C | 1 |
| Kortenkamp, A | 1 |
| Hass, U | 1 |
| Wang, C | 1 |
| Allegaert, K | 1 |
| Tibboel, D | 1 |
| Danhof, M | 1 |
| van der Marel, CD | 1 |
| Mathot, RA | 1 |
| Knibbe, CA | 1 |
| Koyanagi, T | 1 |
| Yamaura, Y | 1 |
| Yano, K | 1 |
| Kim, S | 1 |
| Yamazaki, H | 1 |
| Veal, FC | 1 |
| Bereznicki, LR | 1 |
| Thompson, AJ | 1 |
| Peterson, GM | 1 |
| Kane, AE | 1 |
| Mitchell, SJ | 3 |
| Jones, B | 2 |
| Cogger, V | 1 |
| Sandvik, R | 1 |
| Selbaek, G | 1 |
| Kirkevold, O | 1 |
| Aarsland, D | 1 |
| Husebo, BS | 1 |
| Ferreira, ML | 1 |
| McLachlan, A | 1 |
| Mast, C | 1 |
| Savary-Auzeloux, I | 1 |
| Remond, D | 1 |
| Pouyet, C | 1 |
| Centeno, D | 1 |
| Voyard, G | 1 |
| Combaret, L | 1 |
| Dardevet, D | 2 |
| Papet, I | 3 |
| Sharpe, RJ | 1 |
| Wu, M | 4 |
| Desai, DH | 1 |
| Kakarla, SK | 4 |
| Katta, A | 5 |
| Paturi, S | 4 |
| Gutta, AK | 1 |
| Rice, KM | 5 |
| Walker, EM | 2 |
| Blough, ER | 5 |
| Anderson, BJ | 1 |
| Holford, NH | 1 |
| Sharifi, K | 1 |
| Grünberg, W | 1 |
| Soroori, S | 1 |
| Mohri, M | 1 |
| Ahrari-Khafi, MS | 1 |
| Gadde, MK | 1 |
| Liu, H | 2 |
| Fannin, J | 2 |
| Arvapalli, RK | 2 |
| Wang, Y | 2 |
| Evers, S | 1 |
| Peikert, A | 1 |
| Frese, A | 1 |
| Taguchi, K | 1 |
| Maher, JM | 1 |
| Suzuki, T | 1 |
| Kawatani, Y | 1 |
| Motohashi, H | 1 |
| Yamamoto, M | 1 |
| Fannin, JC | 1 |
| Keshavarzian, S | 1 |
| Nalabotu, SK | 1 |
| Manzoor, K | 1 |
| Banz, VM | 1 |
| Christen, B | 1 |
| Paul, K | 1 |
| Martinolli, L | 1 |
| Candinas, D | 1 |
| Zimmermann, H | 1 |
| Exadaktylos, AK | 1 |
| Liss, G | 1 |
| Rattan, S | 1 |
| Lewis, JH | 1 |
| Karkala, SK | 1 |
| Liukas, A | 1 |
| Kuusniemi, K | 1 |
| Aantaa, R | 1 |
| Virolainen, P | 1 |
| Niemi, M | 1 |
| Neuvonen, PJ | 1 |
| Olkkola, KT | 1 |
| McLachlan, AJ | 1 |
| Pujos-Guillot, E | 2 |
| Pickering, G | 3 |
| Lyan, B | 1 |
| Ducheix, G | 1 |
| Brandolini-Bunlon, M | 1 |
| Glomot, F | 1 |
| Dubray, C | 2 |
| Murnion, BP | 1 |
| Matthews, S | 1 |
| Milder, TY | 1 |
| Lipworth, WL | 1 |
| Williams, KM | 1 |
| Ritchie, JE | 1 |
| Day, RO | 1 |
| Costelloe, C | 1 |
| Montgomery, AA | 1 |
| Redmond, NM | 1 |
| Fletcher, M | 1 |
| Hollinghurst, S | 1 |
| Peters, TJ | 1 |
| Hay, AD | 1 |
| Schneider, E | 1 |
| Pereira, B | 1 |
| Simen, E | 1 |
| Schoeffler, P | 1 |
| Mohammed, BS | 1 |
| Engelhardt, T | 1 |
| Cameron, GA | 1 |
| Cameron, L | 1 |
| Hawksworth, GM | 1 |
| Hawwa, AF | 1 |
| McElnay, J | 1 |
| Helms, PJ | 1 |
| McLay, JS | 1 |
| Meduru, S | 1 |
| Mupparaju, SP | 1 |
| Kidd, B | 1 |
| Goebel, LJ | 1 |
| Tripathy, D | 1 |
| Sanchez, A | 1 |
| Yin, X | 1 |
| Martinez, J | 1 |
| Grammas, P | 1 |
| Xu, YQ | 1 |
| Zhang, D | 1 |
| Jin, T | 1 |
| Cai, DJ | 1 |
| Wu, Q | 1 |
| Lu, Y | 1 |
| Liu, J | 1 |
| Klaassen, CD | 1 |
| Jourdan, D | 1 |
| Marchand, F | 1 |
| Gaulier, JM | 1 |
| Alliot, J | 1 |
| Eschalier, A | 1 |
| Kang, JH | 1 |
| Grodstein, F | 1 |
| BAADER, H | 1 |
| GIRGIS, S | 1 |
| KIESE, M | 1 |
| MENZEL, H | 1 |
| SKROBOT, L | 1 |
| Wauthier, V | 1 |
| Verbeeck, RK | 1 |
| Buc Calderon, P | 1 |
| Platz, EA | 1 |
| Rohrmann, S | 1 |
| Pearson, JD | 1 |
| Corrada, MM | 1 |
| Watson, DJ | 1 |
| De Marzo, AM | 1 |
| Landis, PK | 1 |
| Metter, EJ | 1 |
| Carter, HB | 1 |
| Miller, RA | 2 |
| Buehner, G | 1 |
| Chang, Y | 2 |
| Harper, JM | 2 |
| Sigler, R | 1 |
| Smith-Wheelock, M | 1 |
| Whelton, A | 1 |
| Salmon, AB | 1 |
| Bonkowski, M | 1 |
| Bartke, A | 1 |
| Morishita, K | 1 |
| Mizukawa, Y | 1 |
| Kasahara, T | 1 |
| Okuyama, M | 1 |
| Takashima, K | 1 |
| Toritsuka, N | 1 |
| Miyagishima, T | 1 |
| Nagao, T | 1 |
| Urushidani, T | 1 |
| Larner, AJ | 1 |
| Greenblatt, DJ | 3 |
| Abernethy, DR | 3 |
| Divoll, M | 3 |
| Ochs, HR | 1 |
| Shader, RI | 1 |
| Barber, DJ | 1 |
| Fairhurst, S | 1 |
| Horton, AA | 1 |
| Kim, CS | 1 |
| O'Tuama, LA | 1 |
| Mann, JD | 1 |
| Roe, CR | 1 |
| Ameer, B | 2 |
| Talcott, RE | 1 |
| Pond, SM | 1 |
| Ketterman, A | 1 |
| Becker, CE | 1 |
| Berlin, CM | 1 |
| Yaffe, SJ | 2 |
| Ragni, M | 1 |
| Al-Turk, WA | 1 |
| Stohs, SJ | 1 |
| Green, MD | 1 |
| Fischer, LJ | 1 |
| Whittington, RM | 1 |
| Barclay, AD | 1 |
| Lauterburg, BH | 1 |
| Vaishnav, Y | 1 |
| Stillwell, WG | 1 |
| Mitchell, JR | 1 |
| Mancini, RE | 1 |
| Sonawane, BR | 1 |
| Mucklow, JC | 1 |
| Fraser, HS | 1 |
| Bulpitt, CJ | 1 |
| Kahn, C | 1 |
| Mould, G | 1 |
| Dollery, CT | 1 |
| Gainsborough, N | 1 |
| Maskrey, VL | 1 |
| Nelson, ML | 1 |
| Keating, J | 1 |
| Sherwood, RA | 1 |
| Jackson, SH | 1 |
| Swift, CG | 1 |
| Malik, NS | 1 |
| Meek, KM | 1 |
| el-Azab, G | 1 |
| Youssef, MK | 1 |
| Higashi, Y | 1 |
| Murakami, T | 1 |
| Yata, N | 1 |
| Satav, JG | 1 |
| Bhattacharya, RK | 1 |
| Allameh, A | 1 |
| Vansoun, EY | 1 |
| Zarghi, A | 1 |
| Rainsford, KD | 1 |
| Roberts, SC | 1 |
| Brown, S | 1 |
| Ranganath, L | 1 |
| Sedgwick, I | 1 |
| Morgan, L | 1 |
| Wright, J | 1 |
| Marks, V | 1 |
| Chen, TS | 2 |
| Richie, JP | 2 |
| Nagasawa, HT | 1 |
| Lang, CA | 2 |
| Isbister, G | 1 |
| Whyte, I | 1 |
| Dawson, A | 1 |
| Schmidt, LE | 1 |
| Dalhoff, K | 1 |
| Poulsen, HE | 1 |
| Strain, WD | 1 |
| Lye, M | 1 |
| Fulton, B | 1 |
| James, O | 2 |
| Rawlins, MD | 2 |
| Hart, JG | 1 |
| Timbrell, JA | 1 |
| Schuurmans, D | 1 |
| Vincent, JE | 1 |
| Bruinvels, J | 1 |
| Bonta, IL | 1 |
| Lambert, GH | 1 |
| Thorgeirsson, SS | 1 |
| Triggs, EJ | 1 |
| Nation, RL | 1 |
| Long, A | 1 |
| Ashley, JJ | 1 |
| Galinsky, RE | 4 |
| Manning, BW | 1 |
| Kimura, RE | 1 |
| Franklin, MR | 3 |
| Rumore, MM | 1 |
| Blaiklock, RG | 1 |
| Herd, B | 2 |
| Wynne, H | 1 |
| Wright, P | 1 |
| Woodhouse, K | 1 |
| Haas, DA | 1 |
| Grad, HA | 1 |
| Hasegawa, R | 1 |
| Takahashi, S | 1 |
| Imaida, K | 1 |
| Yamaguchi, S | 1 |
| Shirai, T | 1 |
| Ito, N | 1 |
| Tarloff, JB | 3 |
| Goldstein, RS | 3 |
| Sozio, RS | 1 |
| Hook, JB | 3 |
| Bärtsch, P | 1 |
| Maggiorini, M | 1 |
| Schobersberger, W | 1 |
| Shaw, S | 1 |
| Rascher, W | 1 |
| Girard, J | 1 |
| Weidmann, P | 1 |
| Oelz, O | 1 |
| Hagen, IJ | 1 |
| Haram, EM | 1 |
| Laake, K | 1 |
| Reyes, JL | 2 |
| Melendez, E | 2 |
| Johnson, DH | 1 |
| Kane, RE | 2 |
| Kalabis, GM | 1 |
| Wells, PG | 1 |
| Wynne, HA | 1 |
| Cope, LH | 1 |
| James, OF | 1 |
| Woodhouse, KW | 1 |
| Silver, AC | 1 |
| Hewitt, WR | 1 |
| Wang, LH | 1 |
| Rudolph, AM | 1 |
| Benet, LZ | 1 |
| Rashid, MU | 1 |
| Bateman, DN | 1 |
| Escalante, BA | 1 |
| Meléndez, MA | 1 |
| Morgan, DG | 1 |
| Rikans, LE | 1 |
| Moore, DR | 1 |
| Adamson, GM | 1 |
| Harman, AW | 1 |
| Miners, JO | 1 |
| Penhall, R | 1 |
| Robson, RA | 1 |
| Birkett, DJ | 1 |
| Ecobichon, DJ | 1 |
| D'Ver, AS | 1 |
| Ehrhart, W | 1 |
| Corcoran, GB | 1 |
| Beierschmitt, WP | 2 |
| Keenan, KP | 2 |
| Weiner, M | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Pharmacokinetics of Intravenous Acetaminophen and Its Metabolites in Obese Children and Adolescents[NCT03192566] | Phase 3 | 6 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for acetaminophen and Aging
| Article | Year |
|---|---|
The Challenges of Treating Sciatica Pain in Older Adults.
Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Aging; Analgesics; Analgesics, Opioid; Anti-Inflammat | 2016 |
Mechanistic basis of using body size and maturation to predict clearance in humans.
Topics: Acetaminophen; Aging; Animals; Body Size; Body Surface Area; Glomerular Filtration Rate; Humans; Kid | 2009 |
Predicting and preventing acute drug-induced liver injury: what's new in 2010?
Topics: Acetaminophen; Adult; Aged; Aging; Alanine Transaminase; Amoxicillin-Potassium Clavulanate Combinati | 2010 |
Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2006 |
Ibuprofen and paracetamol: relative safety in non-prescription dosages.
Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents | 1997 |
Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Aging; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans | 1992 |
Drug therapy for the elderly: what are our concerns in dentistry?
Topics: Acetaminophen; Aged; Aging; Anesthetics, Local; Anti-Infective Agents; Anti-Inflammatory Agents, Non | 1991 |
Effects of eicosanoids on the water and sodium balance of the neonate.
Topics: Acetaminophen; Adult; Aging; Animals; Animals, Newborn; Dinoprostone; Eicosanoids; Humans; Infant, N | 1990 |
4 trials available for acetaminophen and Aging
| Article | Year |
|---|---|
Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults.
Topics: Acetaminophen; Adult; Aging; Analgesics, Non-Narcotic; Child; Child, Preschool; Humans; Infant; Infa | 2014 |
Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids.
Topics: Acetaminophen; Aged; Aging; Algorithms; Amino Acids, Sulfur; Analgesics, Non-Narcotic; Arthritis; Bi | 2012 |
Medicine dosing by weight in the home: can parents accurately weigh preschool children? A method comparison study.
Topics: Acetaminophen; Aging; Anthropometry; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Body Wei | 2011 |
Effect of intravenous atropine on gastric emptying, paracetamol absorption, salivary flow and heart rate in young and fit elderly volunteers.
Topics: Acetaminophen; Adult; Aged; Aging; Atropine; Dose-Response Relationship, Drug; Double-Blind Method; | 1990 |
89 other studies available for acetaminophen and Aging
| Article | Year |
|---|---|
In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.
Topics: Acetaminophen; Aging; Animals; Animals, Newborn; Cell Proliferation; Female; Fertility; Forkhead Box | 2019 |
Extrapolation for a pharmacokinetic model for acetaminophen from adults to neonates: A Latin Hypercube Sampling analysis.
Topics: Acetaminophen; Adult; Age Factors; Aging; Dose-Response Relationship, Drug; Humans; Infant, Newborn; | 2020 |
Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Inflammation; L-La | 2021 |
Analyzing Analgesic Medications in Community-Dwelling Older Adults.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opi | 2019 |
The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induce | 2014 |
Managing osteoarthritis pain in the older population.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Age Factors; Aged; Aging; Analgesics, | 2013 |
Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters.
Topics: Acetaminophen; Aging; Animals; Benzhydryl Compounds; Camphor; Cinnamates; Endocrine Disruptors; Fema | 2014 |
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Topics: Acetaminophen; Age Factors; Aging; Albumins; Animals; Antipyrine; Blood Proteins; Diazepam; Diphenhy | 2014 |
Pharmacological management of pain in Australian Aged Care Facilities.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; An | 2014 |
Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver | 2016 |
Analgesic prescribing patterns in Norwegian nursing homes from 2000 to 2011: trend analyses of four data samples.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; An | 2016 |
Repeated cures with paracetamol worsen sarcopenia in old rats with suboptimal food intake.
Topics: Acetaminophen; Aging; Amino Acids; Animals; Eating; Glutathione; Liver; Male; Muscle Proteins; Muscl | 2016 |
Acetaminophen: the case for a link to neurodegenerative diseases.
Topics: Acetaminophen; Aging; Analgesics; Animals; Humans; Models, Biological; Models, Theoretical; Neurodeg | 2008 |
Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2.
Topics: Acetaminophen; Aging; Animals; Blood Glucose; Enzyme Activation; Glucose Transporter Type 4; Hypergl | 2009 |
Assessment of the acetaminophen absorption test as a diagnostic tool for the evaluation of the reticular groove reflex in lambs.
Topics: Acetaminophen; Administration, Oral; Aging; Analgesics, Non-Narcotic; Animals; Area Under Curve; Fem | 2009 |
Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention.
Topics: Acetaminophen; Actins; Aging; Animals; Apoptosis; Muscle, Skeletal; Myosins; Nitric Oxide Synthase T | 2009 |
Sexual headache in young adolescence: a case report.
Topics: Acetaminophen; Adolescent; Age Factors; Aging; Analgesics, Non-Narcotic; Caregivers; Headache Disord | 2009 |
Genetic analysis of cytoprotective functions supported by graded expression of Keap1.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Aging; Alleles; Animals; Cytoprotection; Cytosk | 2010 |
Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Survival; Myocytes, Cardiac | 2010 |
Gender, age and ethnic aspects of analgesia in acute abdominal pain: is analgesia even across the groups?
Topics: Abdominal Pain; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics; Anti-I | 2012 |
Acetaminophen improves protein translational signaling in aged skeletal muscle.
Topics: Acetaminophen; Aging; Animals; Carrier Proteins; Eukaryotic Initiation Factor-2; Eukaryotic Initiati | 2010 |
Pharmacokinetics of intravenous paracetamol in elderly patients.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Analgesia; Analgesics, Non-Narcotic; Area Unde | 2011 |
Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Antipyretics; Endothelium; Indicator Diluti | 2011 |
Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Analgesics, | 2011 |
"It looks after me": how older patients make decisions about analgesics for osteoarthritis.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics, Non-Narcotic; Anti-Inflammat | 2011 |
Acetaminophen metabolism after major surgery: a greater challenge with increasing age.
Topics: Acetaminophen; Age Factors; Aged; Aging; Analgesics, Non-Narcotic; Analysis of Variance; Female; Fol | 2011 |
Population pharmacokinetics of single-dose intravenous paracetamol in children.
Topics: Acetaminophen; Adolescent; Aging; Analgesics, Non-Narcotic; Anesthesia, General; Blood Specimen Coll | 2012 |
Chronic paracetamol treatment influences indices of reactive oxygen species accumulation in the aging Fischer 344 X Brown Norway rat aorta.
Topics: Acetaminophen; Adenylate Kinase; Aging; Animals; Aorta; Apoptosis; bcl-2-Associated X Protein; Cross | 2012 |
Age-related decrease in cerebrovascular-derived neuroprotective proteins: effect of acetaminophen.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Cerebrovascular Circulatio | 2012 |
Diurnal variation of hepatic antioxidant gene expression in mice.
Topics: Acetaminophen; Aging; Animals; Antioxidants; Circadian Rhythm; CLOCK Proteins; Female; Gene Expressi | 2012 |
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat.
Topics: Acetaminophen; Aging; Analgesics; Animals; Aspirin; Clomipramine; Dose-Response Relationship, Drug; | 2002 |
Regular use of nonsteroidal anti-inflammatory drugs and cognitive function in aging women.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2003 |
[The influence of age on the conversion of phenacetin, p-phenetidin, N-acetyl-p-aminophenol, p-aminophenol and aniline in the dog].
Topics: Acetaminophen; Acetanilides; Aging; Aminophenols; Aniline Compounds; Animals; Dogs; Humans; Phenacet | 1960 |
The use of precision-cut liver slices from male Wistar rats as a tool to study age related changes in CYP3A induction and in formation of paracetamol conjugates.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P | 2004 |
Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging.
Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2005 |
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Blood Glucose; Body Weight; Cataract; Diet; Ene | 2005 |
Stress resistance and aging: influence of genes and nutrition.
Topics: Acetaminophen; Aging; Animals; Cadmium; Caloric Restriction; Cell Line; Diet; Dwarfism; Female; Fibr | 2006 |
Gene expression profile in liver of differing ages of rats after single oral administration of acetaminophen.
Topics: Acetaminophen; Administration, Oral; Aging; Analgesics, Non-Narcotic; Animals; Gene Expression Profi | 2006 |
Late onset migraine with aura: how old is too old?
Topics: Acetaminophen; Age Factors; Age of Onset; Aged; Aging; Analgesics, Non-Narcotic; Brain; Female; Huma | 2007 |
Antipyretic analgesic drugs as models for studies of drug disposition in old age.
Topics: Acetaminophen; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biotransformation; | 1983 |
Effect of old age on paracetamol-induced lipid peroxidation in rat liver.
Topics: Acetaminophen; Aging; Animals; Female; Glutathione; Lipid Peroxides; Liver; Rats; Rats, Inbred Strai | 1983 |
Saturable accumulation of the anionic herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), by rabbit choroid plexus: early developmental origin and interaction with salicylates.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acetaminophen; Aging; Animals; Animals, Newborn; Biological Transpor | 1983 |
Acetaminophen kinetics in the elderly.
Topics: Acetaminophen; Adult; Aged; Aging; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Sex Facto | 1982 |
Age does not alter acetaminophen absorption.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aging; Biological Availability; Female; Gastric Em | 1982 |
Ethylesterases as indicators of liver damage. I. Studies on malathion carboxylesterases.
Topics: Acetaminophen; Adult; Aged; Aging; Animals; Aspartate Aminotransferases; Butylated Hydroxyanisole; C | 1982 |
Disposition of acetaminophen in milk, saliva, and plasma of lactating women.
Topics: Acetaminophen; Adult; Aging; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Lactat | 1980 |
Hepatic glutathione content and aryl hydrocarbon hydroxylase activity of acetaminophen-treated mice as a function of age.
Topics: Acetaminophen; Aging; Animals; Aryl Hydrocarbon Hydroxylases; Enzyme Induction; Female; Glutathione; | 1981 |
Age- and sex-related differences in acetaminophen metabolism in the rat.
Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Female; Glucuronates; Liver; Male; Rats; Sex Factors; | 1981 |
The epidemiology of dextropropoxyphene (Distalgesic) overdose fatalities in Birmingham and the West Midlands.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aging; Alcoholic Intoxication; Chromatography, High Pressure | 1981 |
The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis.
Topics: Acetaminophen; Aging; Animals; Glutathione; Kinetics; Liver; Male; Maleates; Rats | 1980 |
Developmental susceptibility to acetaminophen toxicity.
Topics: Acetaminophen; Aging; Animals; Chemical and Drug Induced Liver Injury; Female; Injections, Intraperi | 1980 |
Environmental factors affecting paracetamol metabolism in London factory and office workers.
Topics: Acetaminophen; Adolescent; Adult; Aging; Alcohol Drinking; Asia; Diet; Environment; Female; Half-Lif | 1980 |
The association of age with gastric emptying.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Female; Gastric Emptying; Half-Life; Humans; I | 1993 |
Vitamins and analgesics in the prevention of collagen ageing.
Topics: Acetaminophen; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Cellula | 1996 |
Acetaminophen plasma level after oral administration in liver cirrhotic patients suffering from schistosomal infection.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aging; Analgesics, Non-Narcotic; Biological Availability; Bi | 1996 |
Respiratory functions in kidney mitochondria following paracetamol administration to young-adult & old rats.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Drug Evaluation, Preclinical; Kidney; Male; | 1997 |
Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Aging; Analgesics, Non-Narcotic; Animals; Glutathione; Inactivation, | 1997 |
The ageing entero-insular axis.
Topics: Acetaminophen; Adult; Aged; Aging; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, T | 1998 |
Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice.
Topics: Acetaminophen; Aging; Animals; Buthionine Sulfoximine; Cysteine; Glutathione; Kidney Cortex; Liver; | 2000 |
Pediatric acetaminophen poisoning.
Topics: Acetaminophen; Adolescent; Aging; Analgesics, Non-Narcotic; Child; Child, Preschool; Confounding Fac | 2001 |
Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Aging; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced L | 2002 |
Chronic pain, bereavement and overdose in a depressed elderly woman.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Aortic Aneurysm, Thoracic; Aspirin; Back Pain; Bereav | 2002 |
The influence of age on the pharmacokinetics of paracetamol [proceedings].
Topics: Acetaminophen; Adult; Aged; Aging; Humans; Kinetics | 1979 |
The effect of age on paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Aging; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1979 |
Increase in body temperature during carrageenin-induced paw oedema in the rat. Effect of non-steroid anti-inflammatory substances and essential fatty acid deficiency.
Topics: Acetaminophen; Aging; Animals; Anti-Inflammatory Agents; Brain Chemistry; Carrageenan; Edema; Fatty | 1979 |
Glutathione in the developing mouse liver--I. Developmental curve and depletion after acetaminophen treatment.
Topics: Acetaminophen; Aging; Animals; Female; Fetus; Glutathione; Liver; Methylcholanthrene; Mice; Mice, In | 1976 |
Pharmacokinetics in the elderly.
Topics: Acetaminophen; Adult; Aged; Aging; Half-Life; Humans; Intestinal Absorption; Kinetics; Male; Metabol | 1975 |
Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine.
Topics: Acetaminophen; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cytochrome P-450 Enzyme Syst | 1992 |
Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney.
Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Body Weight; Cysteine; Cystine; Dose-Response Relatio | 1992 |
The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Glucuron | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Hepatic and renal conjugation (Phase II) enzyme activities in young adult, middle-aged, and senescent male Sprague-Dawley rats.
Topics: Acetaminophen; Aging; Animals; Glucuronosyltransferase; Glutathione Transferase; Kidney; Liver; Male | 1991 |
Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness.
Topics: Acclimatization; Acetaminophen; Adult; Aging; Aldosterone; Altitude Sickness; Blood Proteins; Exerci | 1991 |
Absorption of paracetamol from suppositories in geriatric patients with fecal accumulation in the rectum.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Fecal Impaction; Female; Humans; Intestinal Ab | 1991 |
Effect of aging on hepatic biotransformation in female Fischer 344 rats: changes in sulfotransferase activities are consistent with known gender-related changes in pituitary growth hormone secretion in aging animals.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Growth Hor | 1990 |
Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Li | 1990 |
The association of age and frailty with paracetamol conjugation in man.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aging; Frail Elderly; Humans; Liver; Male; Middle Aged; Orga | 1990 |
Intrinsic susceptibility of the kidney to acetaminophen toxicity in middle-aged rats.
Topics: Acetaminophen; Aging; Animals; Glutathione; Kidney; Kidney Diseases; Male; p-Aminohippuric Acid; Rat | 1990 |
Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods.
Topics: Acetaminophen; Aging; Animals; Animals, Newborn; Female; Fetus; Glucuronates; Half-Life; Male; Pregn | 1990 |
Development of the receptors to prostaglandin E2 in the rat kidney and neonatal renal functions.
Topics: Acetaminophen; Aging; Animals; Dinoprostone; Female; In Vitro Techniques; Indomethacin; Kidney; p-Am | 1989 |
Acetaminophen and p-aminophenol nephrotoxicity in aging male Sprague-Dawley and Fischer 344 rats.
Topics: Acetaminophen; Aging; Aminophenols; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Kidn | 1989 |
Effect of aging on drug-metabolizing enzymes important in acetaminophen elimination.
Topics: Acetaminophen; Aging; Animals; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Glut | 1986 |
Acetaminophen hepatotoxicity in aging rats.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver In | 1988 |
Comparison of the susceptibility of hepatocytes from postnatal and adult mice to hepatotoxins.
Topics: Acetaminophen; Aging; Animals; Animals, Newborn; Catalase; Furosemide; Glutathione; Glutathione Pero | 1988 |
Comparison of paracetamol metabolism in young adult and elderly males.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Half-Life; Humans; Kidney; Male; M | 1988 |
Drug disposition and biotransformation in the developing beagle dog.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Blood Proteins; Dogs; Female; Half-Life; Male; Pha | 1988 |
Influence of advanced age on the formation and elimination of acetaminophen metabolites by male rats.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Kinetics; Male; Rats; Rats, Inbred F344 | 1986 |
Age-related increased susceptibility of male Fischer 344 rats to acetaminophen nephrotoxicity.
Topics: Acetaminophen; Aging; Animals; Blood Urea Nitrogen; Drug Tolerance; Glycosuria; Kidney; Male; Rats; | 1986 |
The development of acetaminophen-induced nephrotoxicity in male Fischer 344 rats of different ages.
Topics: Acetaminophen; Aging; Animals; Blood Urea Nitrogen; Glomerulonephritis; Kidney Diseases; Kidney Tubu | 1986 |