acetaminophen has been researched along with Acute Pain in 128 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among patients with cancer pain on strong opioid regime, acetaminophen may not improve pain control, or decrease total opioid use." | 9.69 | Is Acetaminophen Beneficial in Patients With Cancer Pain Who are on Strong Opioids? A Randomized Controlled Trial. ( Castellano, J; González, A; Leiva-Vásquez, O; Letelier, LM; Pérez-Cruz, PE; Rojas, L; Viviani, P, 2023) |
| "Patients with acute pain were randomized to receive oxycodone/acetaminophen (Oxy) or acetaminophen (APAP)." | 9.51 | Oxycodone induced euphoria in ED patients with acute musculoskeletal pain. A secondary analysis of data from a randomized trial. ( Adewunmi, V; Friedman, BW; Gupta, C; Sapkota, A; Takematsu, M; Williams, AR, 2022) |
| " This study seeks to compare the efficacy of intravenously administered paracetamol, dexketoprofen, and ibuprofen in patients with non-traumatic acute low back pain." | 9.51 | Comparative evaluation of the effectiveness of intravenous paracetamol, dexketoprofen and ibuprofen in acute low back pain. ( Dogan, C; Kemanci, A; Oskay, A; Ozen, M; Seyit, M; Turkcuer, I; Uluturk, M; Yilmaz, A, 2022) |
| "To assess the analgesic efficacy and safety of single-dose oral cannabidiol (CBD) as an adjunct to standard care for patients presenting to an emergency department with acute low back pain." | 9.41 | The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. ( Bebee, B; Bourke, E; Ching, M; Foster, L; Pollack, K; Taylor, DM; Wong, A, 2021) |
| "We compared the analgesic efficacy of a combination of oral ibuprofen plus acetaminophen with either analgesic alone for pediatric ED patients with acute pain." | 9.34 | Comparison of Oral Ibuprofen and Acetaminophen with Either Analgesic Alone for Pediatric Emergency Department Patients with Acute Pain. ( Brady, J; Butt, M; Drapkin, J; Fassassi, C; Flom, P; Hossain, R; Likourezos, A; Marshall, J; Masoudi, A; Motov, S; Palacios, W; Rothberger, N; Zerzan, J, 2020) |
| "To compare the efficacy and safety of IV tramadol versus IV paracetamol in relieving acute pain of primary dysmenorrhea." | 9.34 | Efficacy and Safety of Intravenous Tramadol versus Intravenous Paracetamol for Relief of Acute Pain of Primary Dysmenorrhea: A Randomized Controlled Trial. ( Abbas, AM; Alalfy, M; AlAmodi, AA; Ali, AS; Fadlalmola, HA; Ghamry, NK; Hamza, M; Islam, Y; Mahmoud, AO; Shareef, MA, 2020) |
| "In elderly trauma patients (age ≥65 years) with 1 or more rib fractures, PO acetaminophen is equivalent to IV acetaminophen for pain control, with no difference in morbidity or mortality." | 9.34 | Treatment With Oral Versus Intravenous Acetaminophen in Elderly Trauma Patients With Rib Fractures: A Prospective Randomized Trial. ( Antill, AC; Bollig, RW; Daley, BJ; Ford, BR; Frye, SW; Haynes, JC; McMillen, JC, 2020) |
| "Oral tramadol/acetaminophen combination administered early in triage was associated with a decrease in intravenous morphine requirement and increase in satisfaction among ED patients with acute pain when compared with patients taking acetaminophen." | 9.30 | Effect on Morphine Requirement of Early Administration of Oral Acetaminophen vs. Acetaminophen/Tramadol Combination in Acute Pain. ( Belguith, A; Beltaief, K; Ben Marzouk, M; Boubaker, H; Bouida, W; Boukef, R; Grissa, MH; Methamem, M; Msolli, MA; Nouira, S; Zorgati, A, 2019) |
| "To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12." | 9.30 | Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019) |
| " Studies of intravenous acetaminophen for acute pain in the ED demonstrate mixed results and suffer from small sample sizes and methodological limitations." | 9.30 | Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department. ( Barnaby, DP; Bijur, PE; Campbell, CM; Chertoff, AE; Gallagher, EJ; Pearlman, S; Restivo, AJ; White, D, 2019) |
| "Current worldwide clinical practice guidelines recommend acetaminophen as the first option for the treatment of acute low back pain." | 9.27 | Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain. ( Arai, YC; Hayashi, K; Ikemoto, T; Miki, K; Sekiguchi, M; Shi, K; Ushida, T, 2018) |
| "A fixed-dose combination biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablet is being developed for the management of acute pain severe enough to require opioid treatment and for which alternative treatment options are inadequate." | 9.20 | Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Kostenbader, K; Margulis, R; Singla, N; Young, JL; Zheng, Y, 2015) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 9.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| "This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)." | 9.19 | Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. ( Bijur, PE; Chang, AK; John Gallagher, E; Munjal, KG, 2014) |
| "To investigate in acute nonspecific low back pain (LBP) the effectiveness of spinal high-velocity low-amplitude (HVLA) manipulation compared with the nonsteroidal anti-inflammatory drug diclofenac and with placebo." | 9.17 | Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo. ( Muehlbauer, B; Schloemer, P; Timm, J; von Heymann, WJ, 2013) |
| "Early administration of tramadol and paracetamol provided effective pain relief in patients with non-traumatic acute abdominal pain and those administrations did not interfere with diagnosis." | 9.16 | Tramadol or paracetamol do not effect the diagnostic accuracy of acute abdominal pain with significant pain relief - a prospective, randomized, placebo controlled double blind study. ( Dogan, M; Kayaalp, C; Oguzturk, H; Ozgur, D; Pamukcu, E; Turtay, MG; Yilmaz, S, 2012) |
| "Pregabalin in the doses given decreased morphine requirements for the first 48 h postoperatively, but neither altered the analgesic requirements beyond 48 h nor had any effect on acute, late or chronic pain." | 9.16 | Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Tsaroucha, A, 2012) |
| "Ibuprofen and paracetamol have long been used as analgesics in a range of acute, intermittent and chronic pain conditions." | 8.91 | Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. ( Aldington, DJ; Derry, S; Moore, RA; Straube, S; Wiffen, PJ, 2015) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache." | 8.88 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012) |
| "Nimesulide has been evaluated in numerous clinical studies in the management of a variety of acute painful conditions." | 8.31 | An Open-label, Prospective, Multicentric, Cohort Study of Nimesulide/Paracetamol Fixed Drug Combination for Acute Pain Management: Sub-group Analysis. ( Gondane, A; Muruganathan, A; Pawar, D; Tiwaskar, M, 2023) |
| "Opioid analgesia for acute painful conditions has come under increasing scrutiny with the public health crisis of opioid overdose, leading clinicians to seek nonopioid alternatives, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol)." | 8.02 | Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain? ( Breve, F; LeQuang, JA; Magnusson, P; Pergolizzi, JV; Taylor, R; Varrassi, G; Wollmuth, C, 2021) |
| " The purpose of this study sit to investigate if MSIR combined with Acetaminophen can serve as an opioid analgesic alternative to Oxycodone combined with acetaminophen (Percocet) for acute pain in the Emergency Department (ED)." | 8.02 | Analgesic efficacy of morphine sulfate immediate release vs. oxycodone/acetaminophen for acute pain in the emergency department. ( Butt, M; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Gohel, A; Likourezos, A; Masoudi, A; Motov, S; Silver, M, 2021) |
| " We describe considerations of concurrent buprenorphine/naloxone therapy during episodes of severe acute pain." | 7.79 | Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review. ( Chang-Chien, GC; Chu, SK; Joseph, P; McCormick, Z, 2013) |
| "Cancer pain is one of the most frequent and relevant symptoms in cancer patients and impacts on patient's quality of life." | 7.11 | Randomized double-blind controlled trial to assess the efficacy of intravenous acetaminophen associated with strong opioids in the treatment of acute pain in adult cancer patients: study protocol. ( Castellano, J; Gonzalez, A; Leiva, O; Letelier, LM; Perez-Cruz, P; Rojas, L; Viviani, P, 2022) |
| " Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances." | 6.82 | Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022) |
| " Secondary endpoints included SPID at additional time points, total pain relief at all on-therapy time points (TOTPAR), sum of SPID and TOTPAR at all on-therapy time points (SPID + TOTPAR), use of rescue medication, subjective pain assessment (PGIC, Patient Global Impression of Change), and adverse events (AEs)." | 6.80 | A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. ( Bin, SI; Chang, N; Cho, SD; Choi, CH; Ha, CW; Kang, SB; Kyung, HS; Lee, JH; Lee, MC; Park, YB; Rhim, HY; Seo, SS, 2015) |
| "Acetaminophen (APAP) is a mainstay for pain management worldwide." | 6.53 | The Use of Intravenous Acetaminophen for Acute Pain in the Emergency Department. ( Motov, SM; Sin, B; Tatunchak, T; Wai, M, 2016) |
| "As compared with placebo, VX-548 at the highest dose, but not at lower doses, reduced acute pain over a period of 48 hours after abdominoplasty or bunionectomy." | 5.69 | Selective Inhibition of Na ( Beaton, A; Bertoch, T; Bozic, C; Buvanendran, A; Correll, DJ; Habib, AS; Hare, B; Jazic, I; Jones, J; Lechner, SM; Miao, X; Negulescu, P; Osteen, JD; Pizzi, LJ; Pollak, RA; Shaw, D; Simard, C; Weiner, SG; White, PF, 2023) |
| "Among patients with cancer pain on strong opioid regime, acetaminophen may not improve pain control, or decrease total opioid use." | 5.69 | Is Acetaminophen Beneficial in Patients With Cancer Pain Who are on Strong Opioids? A Randomized Controlled Trial. ( Castellano, J; González, A; Leiva-Vásquez, O; Letelier, LM; Pérez-Cruz, PE; Rojas, L; Viviani, P, 2023) |
| " This study seeks to compare the efficacy of intravenously administered paracetamol, dexketoprofen, and ibuprofen in patients with non-traumatic acute low back pain." | 5.51 | Comparative evaluation of the effectiveness of intravenous paracetamol, dexketoprofen and ibuprofen in acute low back pain. ( Dogan, C; Kemanci, A; Oskay, A; Ozen, M; Seyit, M; Turkcuer, I; Uluturk, M; Yilmaz, A, 2022) |
| "5 mg of intravenous hydromorphone among patients aged 65 years or more with acute pain of severity that was sufficient enough to warrant intravenous opioids." | 5.51 | A Randomized Study of Intravenous Hydromorphone Versus Intravenous Acetaminophen for Older Adult Patients with Acute Severe Pain. ( Afrifa, F; Chang, AK; Feliciano, C; Friedman, BW; Irizarry, E; Izzo, A; Kolli, S; Latev, A; Naeem, F; Walker, C, 2022) |
| "Patients with acute pain were randomized to receive oxycodone/acetaminophen (Oxy) or acetaminophen (APAP)." | 5.51 | Oxycodone induced euphoria in ED patients with acute musculoskeletal pain. A secondary analysis of data from a randomized trial. ( Adewunmi, V; Friedman, BW; Gupta, C; Sapkota, A; Takematsu, M; Williams, AR, 2022) |
| "Both ESB and PVB were effective in controlling acute pain and persistent herpetic pain after 6 months (which was evident by lower NRS for pain and doses of pregabalin and acetaminophen), but ESB is safer (no reported pneumothorax and hypotension)." | 5.51 | Ultrasound-Guided Erector Spinae Block Versus Ultrasound-Guided Thoracic Paravertebral Block for Pain Relief in Patients With Acute Thoracic Herpes Zoster: A Randomized Controlled Trial. ( Abdelwahab, EH; Afandy, ME; Fattooh, NH; Hodeib, AA; Marof, HM, 2022) |
| "Nonopioid medications, specifically nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen alone or in combination with acetaminophen, are recommended for managing acute dental pain after 1 or more tooth extractions (that is, simple and surgical) and the temporary management of toothache in children (conditional recommendation, very low certainty)." | 5.41 | Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Cen ( Aghaloo, T; Carrasco-Labra, A; Claytor, JW; Dawson, T; Dhar, V; Dionne, RA; Espinoza, L; Gordon, SM; Hersh, EV; Law, AS; Li, BS; Miroshnychenko, A; Moore, PA; Pahlke, S; Pilcher, L; Polk, DE; Schwartz, PJ; Shirey, M; Suda, KJ; Tampi, M; Turturro, MA; Urquhart, O; Wright, ML, 2023) |
| "To assess the analgesic efficacy and safety of single-dose oral cannabidiol (CBD) as an adjunct to standard care for patients presenting to an emergency department with acute low back pain." | 5.41 | The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. ( Bebee, B; Bourke, E; Ching, M; Foster, L; Pollack, K; Taylor, DM; Wong, A, 2021) |
| "To compare the efficacy and safety of IV tramadol versus IV paracetamol in relieving acute pain of primary dysmenorrhea." | 5.34 | Efficacy and Safety of Intravenous Tramadol versus Intravenous Paracetamol for Relief of Acute Pain of Primary Dysmenorrhea: A Randomized Controlled Trial. ( Abbas, AM; Alalfy, M; AlAmodi, AA; Ali, AS; Fadlalmola, HA; Ghamry, NK; Hamza, M; Islam, Y; Mahmoud, AO; Shareef, MA, 2020) |
| "In elderly trauma patients (age ≥65 years) with 1 or more rib fractures, PO acetaminophen is equivalent to IV acetaminophen for pain control, with no difference in morbidity or mortality." | 5.34 | Treatment With Oral Versus Intravenous Acetaminophen in Elderly Trauma Patients With Rib Fractures: A Prospective Randomized Trial. ( Antill, AC; Bollig, RW; Daley, BJ; Ford, BR; Frye, SW; Haynes, JC; McMillen, JC, 2020) |
| " The purpose of this study was to compare the efficacy of intranasal ketorolac (Sprix; Egalet US Inc, Wayne, PA) with a combination of ibuprofen/acetaminophen in an acute pain model of untreated endodontic patients experiencing moderate to severe pain and symptomatic apical periodontitis." | 5.30 | Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation. ( Balzer, S; Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Watts, K, 2019) |
| "To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12." | 5.30 | Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019) |
| "Current worldwide clinical practice guidelines recommend acetaminophen as the first option for the treatment of acute low back pain." | 5.27 | Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain. ( Arai, YC; Hayashi, K; Ikemoto, T; Miki, K; Sekiguchi, M; Shi, K; Ushida, T, 2018) |
| "Anesthesia, acetaminophen, Persistent surgical pain, Postoperative acute pain." | 5.27 | Acetaminophen reduces acute and persistent incisional pain after hysterectomy. ( Akkurt, C; Hakimoglu, S; Koyuncu, O; Sessler, D; Turan, A; Turhanoglu, S; Ugur, M, 2018) |
| "One hundred and seventy four discharged ED patients prescribed hydrocodone-acetaminophen for acute pain." | 5.22 | Emergency Department Patient Perspectives on the Risk of Addiction to Prescription Opioids. ( Ahlstrom, E; Cameron, KA; Chevrier, A; Conrardy, M; Courtney, DM; Lank, P; McCarthy, DM; McConnell, R; Sears, J; Wolf, MS, 2016) |
| "A fixed-dose combination biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablet is being developed for the management of acute pain severe enough to require opioid treatment and for which alternative treatment options are inadequate." | 5.20 | Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Kostenbader, K; Margulis, R; Singla, N; Young, JL; Zheng, Y, 2015) |
| "This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)." | 5.19 | Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. ( Bijur, PE; Chang, AK; John Gallagher, E; Munjal, KG, 2014) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 5.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| "To investigate the safety and satisfaction of patients treated ≤ 14 days after unilateral bunionectomy with extended-release oxycodone/acetaminophen (ER OC/APAP), a biphasic (ER and immediate release) fixed-dose combination analgesic being developed for moderate to severe acute pain." | 5.19 | Assessment of the safety and efficacy of extended-release oxycodone/acetaminophen, for 14 days postsurgery. ( Barrett, T; Kostenbader, K; Singla, N; Sisk, L; Young, J, 2014) |
| "To investigate the efficacy and safety of a bilayer combination oxycodone (OC) and acetaminophen (APAP) analgesic with both immediate-release and extended-release (ER) components (OC/APAP ER) in patients with moderate to severe pain using an established acute pain model." | 5.19 | A randomized, double-blind, placebo-controlled study of the efficacy and safety of MNK-795, a dual-layer, biphasic, immediate-release and extended-release combination analgesic for acute pain. ( Barrett, T; Giuliani, M; Kostenbader, K; Singla, N; Sisk, L; Young, J, 2014) |
| "Paracetamol (acetaminophen) is recommended in most clinical practice guidelines as the first choice of treatment for low back pain, however there is limited evidence to support this recommendation." | 5.17 | PACE--the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan. ( Billot, L; Day, RO; Hancock, MJ; Latimer, J; Lin, CW; Maher, CG; McLachlan, AJ; Williams, CM, 2013) |
| "To investigate in acute nonspecific low back pain (LBP) the effectiveness of spinal high-velocity low-amplitude (HVLA) manipulation compared with the nonsteroidal anti-inflammatory drug diclofenac and with placebo." | 5.17 | Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo. ( Muehlbauer, B; Schloemer, P; Timm, J; von Heymann, WJ, 2013) |
| "Pregabalin in the doses given decreased morphine requirements for the first 48 h postoperatively, but neither altered the analgesic requirements beyond 48 h nor had any effect on acute, late or chronic pain." | 5.16 | Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Tsaroucha, A, 2012) |
| "Early administration of tramadol and paracetamol provided effective pain relief in patients with non-traumatic acute abdominal pain and those administrations did not interfere with diagnosis." | 5.16 | Tramadol or paracetamol do not effect the diagnostic accuracy of acute abdominal pain with significant pain relief - a prospective, randomized, placebo controlled double blind study. ( Dogan, M; Kayaalp, C; Oguzturk, H; Ozgur, D; Pamukcu, E; Turtay, MG; Yilmaz, S, 2012) |
| "บทนำ: อาการปวดฝีเย็บเป็นผลข้างเคียงที่พบบ่อยหลังการคลอดบุตร แต่มีการศึกษาไม่ดี ความเจ็บปวดอาจเป็นผลมาจากการบาดเจ็บของฝีเย็บอันเนื่องมาจากรอยฟกช้ำ การฉีกขาดที่เกิดขึ้นเอง การตัด (ตัดฝีเย็บ) หรือเกี่ยวกับการคลอดทางช่องคลอด (การคลอดด้วยเครื่องดูดหรือด้วยคีม) นี่คือการอัปเดตของการทบทวนวรรณกรรมที่เผยแพร่ล่าสุดในปี 2013 วัตถุประสงค์: เพื่อประเมินประสิทธิภาพของการใช้ยาพาราเซตามอล (acetaminophen) เพียงครั้งเดียวที่ใช้ในการบรรเทาอาการปวดฝีเย็บเฉียบพลันหลังคลอด วิธีการสืบค้น: สำหรับการอัปเดตนี้เราได้ค้นหา Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials." | 5.12 | Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Gyte, GM; Sguassero, Y, 2021) |
| "Topical NSAIDs, followed by oral NSAIDs and acetaminophen with or without diclofenac, showed the most convincing and attractive benefit-harm ratio for patients with acute pain from non-low back, musculoskeletal injuries." | 5.05 | Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries : A Systematic Review and Network Meta-analysis of Randomized Trials. ( Agarwal, A; Akbari-Kelachayeh, K; Ali, SH; Brar, S; Busse, JW; Chang, Y; Chen, E; Couban, R; Craigie, S; Culig, K; Das, A; Emary, P; Florez, ID; Goshua, A; Guyatt, GH; Hong, PJ; Lok, A; May, C; Morgan, RL; Noor, ST; Oparin, Y; Pozdnyakov, A; Ross, SA; Sadeghirad, B; Shergill, Y; Sivananthan, L; Yao, W; Zihayat, B, 2020) |
| "Ibuprofen resulted to be more effective than acetaminophen, and comparable to the combination acetaminophen-codeine, for the control of acute pain related to musculoskeletal pain." | 5.01 | Ibuprofen for Pain Control in Children: New Value for an Old Molecule. ( Brambilla, I; Licari, A; Marseglia, GL; Poddighe, D, 2019) |
| " New evidence found that acetaminophen was ineffective for acute low back pain, nonsteroidal anti-inflammatory drugs had smaller benefits for chronic low back pain than previously observed, duloxetine was effective for chronic low back pain, and benzodiazepines were ineffective for radiculopathy." | 4.95 | Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. ( Chou, R; Dana, T; Deyo, R; Friedly, J; Fu, R; Griffin, J; Grusing, S; Kraegel, P; Skelly, A; Weimer, M, 2017) |
| " Paracetamol (acetaminophen) is the most commonly prescribed analgesic for the treatment of acute pain." | 4.93 | Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. ( Carr, DB; Ferguson, MC; Haroutounian, S; McNicol, ED; Schumann, R, 2016) |
| "Ibuprofen and paracetamol have long been used as analgesics in a range of acute, intermittent and chronic pain conditions." | 4.91 | Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. ( Aldington, DJ; Derry, S; Moore, RA; Straube, S; Wiffen, PJ, 2015) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache." | 4.88 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012) |
| "Nimesulide has been evaluated in numerous clinical studies in the management of a variety of acute painful conditions." | 4.31 | An Open-label, Prospective, Multicentric, Cohort Study of Nimesulide/Paracetamol Fixed Drug Combination for Acute Pain Management: Sub-group Analysis. ( Gondane, A; Muruganathan, A; Pawar, D; Tiwaskar, M, 2023) |
| "Regression analysis showed that severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were both one of the risk factors for postoperative chronic pain." | 4.02 | A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period. ( Chang, QY; Chen, J; Gan, ZJ; Li, TT; Wang, YT; Wen, S; Xiong, LL; Yuan, H, 2021) |
| "Opioid analgesia for acute painful conditions has come under increasing scrutiny with the public health crisis of opioid overdose, leading clinicians to seek nonopioid alternatives, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol)." | 4.02 | Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain? ( Breve, F; LeQuang, JA; Magnusson, P; Pergolizzi, JV; Taylor, R; Varrassi, G; Wollmuth, C, 2021) |
| "The additional use of intravenous acetaminophen did not decrease opioid requirement in adult patients with acute pain during Emergency Department stay." | 4.02 | Intravenous acetaminophen does not have an opioid sparing effect in Emergency Department patients with painful conditions. ( Berendsen, M; Blok, Z; Goddijn, H; Hollmann, MW; Ridderikhof, ML, 2021) |
| " We describe considerations of concurrent buprenorphine/naloxone therapy during episodes of severe acute pain." | 3.79 | Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review. ( Chang-Chien, GC; Chu, SK; Joseph, P; McCormick, Z, 2013) |
| "The study included 113 breast cancer patients after breast cancer surgery with axillary lymphadenectomy treated with either 75/650 mg or 37." | 3.30 | Association of ( Besic, N; Dolzan, V; Goricar, K; Strazisar, B; Vidic, Z, 2023) |
| "Cancer pain is one of the most frequent and relevant symptoms in cancer patients and impacts on patient's quality of life." | 3.11 | Randomized double-blind controlled trial to assess the efficacy of intravenous acetaminophen associated with strong opioids in the treatment of acute pain in adult cancer patients: study protocol. ( Castellano, J; Gonzalez, A; Leiva, O; Letelier, LM; Perez-Cruz, P; Rojas, L; Viviani, P, 2022) |
| "Primary outcomes were low back pain intensity (0-100 scale) at end of treatment and safety (number of participants who reported any adverse event during treatment)." | 3.01 | Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis. ( Bagg, MK; Cashin, AG; Day, R; Ferraro, MC; Gustin, SM; Hagstrom, AD; Jones, MD; Leake, HB; Maher, CG; McAuley, JH; McLachlan, AJ; Nikolakopolou, A; O'Connell, NE; Rizzo, RR; Schabrun, S; Sharma, S; Wand, BM; Wewege, MA, 2023) |
| " Adverse event data was collected throughout the study, in addition to scheduled vital sign assessments, laboratory tests and electrocardiograms." | 3.01 | Extending the safety profile of the post-operative administration of an intravenous acetaminophen/ibuprofen fixed dose combination: An open-label, multi-center, single arm, multiple dose study. ( Atkinson, H; Carson, S; Gilchrist, N; Gottlieb, IJ; Stanescu, I, 2021) |
| "Limiting harm from postoperative pain treatment is important." | 2.94 | The PANSAID randomized clinical trial: A pre-planned 1-year follow-up regarding harm. ( Hägi-Pedersen, D; Mathiesen, O; Overgaard, S; Thybo, KH; Wetterslev, J, 2020) |
| " Adverse events (all non-serious) were reported by 17% of methoxyflurane-treated patients and 3% of SAT-treated patients." | 2.90 | Analgesic Efficacy, Practicality and Safety of Inhaled Methoxyflurane Versus Standard Analgesic Treatment for Acute Trauma Pain in the Emergency Setting: A Randomised, Open-Label, Active-Controlled, Multicentre Trial in Italy (MEDITA). ( Bonafede, E; Carpinteri, G; Fabbri, A; Farina, A; Gangitano, G; Intelligente, F; Mercadante, S; Ruggiano, G; Sblendido, A; Serra, S; Soldi, A; Voza, A, 2019) |
| "Average postoperative pain intensity using a numerical rating scale and use of rescue medication were measured in the postanaesthesia care unit (PACU) and on postoperative days (POD) 1 to 3." | 2.90 | Metamizole vs. ibuprofen at home after day case surgery: A double-blind randomised controlled noninferiority trial. ( Boon, M; Buhre, WFFA; Evers, S; Joosten, EA; Ory, JP; Pelckmans, C; Stessel, B; Van de Velde, M; van Kuijk, SMJ; Wyckmans, W, 2019) |
| "Acute pain is a significant burden to the individual and to society." | 2.87 | Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial. ( Atkinson, HC; Daniels, SE; Frampton, C; Stanescu, I, 2018) |
| " This was performed by comparison of mean pain intensity difference, total pain relief at 2 h, onset of pain relief, decrease in number of pain episodes, global improvement, and adverse effects." | 2.87 | Efficacy and safety of fixed-dose combination of drotaverine hydrochloride (80 mg) and paracetamol (500 mg) in amelioration of abdominal pain in acute infectious gastroenteritis: A randomized controlled trial. ( Koli, J; Narang, S, 2018) |
| " Further research to assess adverse events and other dosing may be warranted." | 2.84 | Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial. ( Baer, J; Barnaby, DP; Bijur, PE; Chang, AK; Esses, D, 2017) |
| " Rather, dosing for adults who are older and/or have decompensated cirrhosis, advanced kidney failure, or analgesic-induced asthma that is known to be cross-sensitive to paracetamol, should be individualized in consultation with their physician, who may recommend a lower effective dose appropriate to the circumstances." | 2.82 | Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older. ( Alchin, J; Christo, PJ; Dhar, A; Siddiqui, K, 2022) |
| " Secondary endpoints included SPID at additional time points, total pain relief at all on-therapy time points (TOTPAR), sum of SPID and TOTPAR at all on-therapy time points (SPID + TOTPAR), use of rescue medication, subjective pain assessment (PGIC, Patient Global Impression of Change), and adverse events (AEs)." | 2.80 | A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. ( Bin, SI; Chang, N; Cho, SD; Choi, CH; Ha, CW; Kang, SB; Kyung, HS; Lee, JH; Lee, MC; Park, YB; Rhim, HY; Seo, SS, 2015) |
| "Our findings suggest that regular or as-needed dosing with paracetamol does not affect recovery time compared with placebo in low-back pain, and question the universal endorsement of paracetamol in this patient group." | 2.79 | Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. ( Day, RO; Hancock, MJ; Latimer, J; Lin, CW; Maher, CG; McLachlan, AJ; Williams, CM, 2014) |
| "Headache is an increasingly common symptom among children and adolescents with a prevalence of 58." | 2.58 | [Headache in children and adolescents]. ( Debes, NM; Gren, C; Miranda, M; Vogler, K, 2018) |
| "Acute postoperative pain occurs as a result of tissue damage following surgery." | 2.52 | As required versus fixed schedule analgesic administration for postoperative pain in children. ( Conlon, JA; Hobson, A; Wiffen, PJ, 2015) |
| "Severe acute pain is typically treated with potent opioids." | 2.49 | Pharmacologic therapy for acute pain. ( Azadfard, M; Blondell, RD; Wisniewski, AM, 2013) |
| "In case of neuropathic pain, the benefit deriving from the use of a single active principle is relative." | 2.48 | [Skin ulcer pain]. ( Guerra, L; Pellicano, R, 2012) |
| "Acute pain is a common symptom in children of all ages, and is associated with a variety of conditions." | 1.91 | Paracetamol and ibuprofen combination for the management of acute mild-to-moderate pain in children: expert consensus using the Nominal Group Technique (NGT). ( Chiarugi, A; Cortis, E; D'Avino, A; Lanari, M; Marchisio, PG; Parri, N; Silvagni, D; Staiano, A; Vezzoli, C; Zampogna, S, 2023) |
| "Acute pain is the most common type of pain." | 1.91 | Evaluation of antinociceptive effect and pharmacological mechanisms of thiocyanoacetamide in rats. ( Ben Akacha, A; Ben Ali, R; Ben Othman, A; El May, MV, 2023) |
| "The aim of this study is to assess the current situation in out of hospital pain management in Germany regarding the substances, indications, dosage and the delegation of the use of analgesics to emergency medical service (EMS) staff." | 1.91 | Application of analgesics in emergency services in Germany: a survey of the medical directors. ( Scharonow, M; Scharonow, O; Vilcane, S; Weilbach, C, 2023) |
| "Acetaminophen was mixed with all 18 solutions and was examined at time 0, 15, 30, and 60 min." | 1.72 | Compatibility of intravenous acetaminophen with morphine, fentanyl and ketamine in acute pediatric pain setting. ( Chan, MTV; Cheaib, A; O'Loughlin, E; Peng, YG; Williams, R, 2022) |
| "Acute pain was associated with a variety of surgical procedures and patients were examined before and after surgical procedures." | 1.48 | The glycation products before and after therapy for acute and chronic pain. ( Fricová, J; Holeček, V; Houdek, K; Lejčko, J; Nedvídek, J; Rokyta, R; Trefil, L, 2018) |
| "Study selectionAll Cochrane reviews of RCTs between 1999 to 2015, conducted in adults examining the adverse events associated with single dose oral analgesics used for acute post-operative pain were considered." | 1.43 | Single dose oral analgesics for postoperative pain have few adverse events. ( Wong, YJ, 2016) |
| "Acute pain following inguinal hernia repair can be difficult to treat." | 1.42 | Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain. ( Bannerton, K; Bree, D; Broom, DC; Finn, DP; Kelly, JP; Moriarty, O; Morris, B; O'Mahony, CM; Roche, M, 2015) |
| "Untreated postoperative pain is an important ethical and financial issue that can lead to unnecessary suffering and prolonged stays in hospital." | 1.37 | Reducing postoperative pain by changing the process. ( Armstrong, D; Boardman, C; Coulthard, P; Crawford, FI, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 80 (62.50) | 24.3611 |
| 2020's | 48 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ferguson, MC | 2 |
| Schumann, R | 2 |
| Gallagher, S | 1 |
| McNicol, ED | 2 |
| Abalos, E | 1 |
| Sguassero, Y | 1 |
| Gyte, GM | 1 |
| Lindbeck, G | 1 |
| Shah, MI | 1 |
| Braithwaite, S | 1 |
| Powell, JR | 1 |
| Panchal, AR | 1 |
| Browne, LR | 1 |
| Lang, ES | 1 |
| Burton, B | 1 |
| Coughenour, J | 1 |
| Crowe, RP | 1 |
| Degn, H | 1 |
| Hedges, M | 1 |
| Gasper, J | 1 |
| Guild, K | 1 |
| Mattera, C | 1 |
| Nasca, S | 1 |
| Taillac, P | 1 |
| Warth, M | 1 |
| Sapkota, A | 1 |
| Takematsu, M | 1 |
| Adewunmi, V | 1 |
| Gupta, C | 1 |
| Williams, AR | 1 |
| Friedman, BW | 5 |
| Wilson, SH | 1 |
| Wilson, PR | 1 |
| Bridges, KH | 1 |
| Bell, LH | 1 |
| Clark, CA | 1 |
| Alchin, J | 1 |
| Dhar, A | 1 |
| Siddiqui, K | 1 |
| Christo, PJ | 1 |
| O'Loughlin, E | 1 |
| Peng, YG | 1 |
| Cheaib, A | 1 |
| Chan, MTV | 1 |
| Williams, R | 1 |
| Dogan, C | 1 |
| Yilmaz, A | 1 |
| Ozen, M | 1 |
| Seyit, M | 1 |
| Oskay, A | 1 |
| Kemanci, A | 1 |
| Uluturk, M | 1 |
| Turkcuer, I | 1 |
| Minotti, B | 1 |
| Mansella, G | 1 |
| Sieber, R | 1 |
| Ott, A | 1 |
| Nickel, CH | 1 |
| Bingisser, R | 1 |
| Anderson, DB | 1 |
| Shaheed, CA | 1 |
| Leiva, O | 1 |
| Castellano, J | 2 |
| Letelier, LM | 2 |
| Rojas, L | 2 |
| Viviani, P | 2 |
| Gonzalez, A | 2 |
| Perez-Cruz, P | 1 |
| Nelson, R | 1 |
| Kittel-Moseley, J | 1 |
| Mahoui, I | 1 |
| Thornberry, D | 1 |
| Dunkman, A | 1 |
| Sams, M | 1 |
| Adler, D | 1 |
| Jones, CMC | 1 |
| Kolli, S | 1 |
| Latev, A | 1 |
| Chang, AK | 7 |
| Naeem, F | 1 |
| Feliciano, C | 2 |
| Afrifa, F | 1 |
| Walker, C | 1 |
| Izzo, A | 1 |
| Irizarry, E | 2 |
| Abdelwahab, EH | 1 |
| Hodeib, AA | 1 |
| Marof, HM | 1 |
| Fattooh, NH | 1 |
| Afandy, ME | 1 |
| Cattin, G | 2 |
| Jenvrin, J | 2 |
| Hardouin, JB | 2 |
| Longo, C | 2 |
| Montassier, E | 2 |
| Miroshnychenko, A | 3 |
| Ibrahim, S | 2 |
| Azab, M | 2 |
| Roldan, Y | 2 |
| Martinez, JPD | 1 |
| Tamilselvan, D | 2 |
| He, L | 2 |
| Little, JW | 1 |
| Urquhart, O | 3 |
| Tampi, M | 3 |
| Polk, DE | 3 |
| Moore, PA | 5 |
| Hersh, EV | 4 |
| Claytor, B | 1 |
| Carrasco-Labra, A | 4 |
| Brignardello-Petersen, R | 2 |
| Baroncini, A | 1 |
| Maffulli, N | 1 |
| Al-Zyoud, H | 1 |
| Bell, A | 1 |
| Sevic, A | 1 |
| Migliorini, F | 1 |
| Vidic, Z | 1 |
| Goricar, K | 1 |
| Strazisar, B | 1 |
| Besic, N | 1 |
| Dolzan, V | 1 |
| Parri, N | 1 |
| Silvagni, D | 2 |
| Chiarugi, A | 1 |
| Cortis, E | 1 |
| D'Avino, A | 1 |
| Lanari, M | 1 |
| Marchisio, PG | 1 |
| Vezzoli, C | 1 |
| Zampogna, S | 1 |
| Staiano, A | 1 |
| Wewege, MA | 1 |
| Bagg, MK | 2 |
| Jones, MD | 1 |
| Ferraro, MC | 1 |
| Cashin, AG | 2 |
| Rizzo, RR | 2 |
| Leake, HB | 1 |
| Hagstrom, AD | 1 |
| Sharma, S | 1 |
| McLachlan, AJ | 5 |
| Maher, CG | 7 |
| Day, R | 1 |
| Wand, BM | 2 |
| O'Connell, NE | 2 |
| Nikolakopolou, A | 1 |
| Schabrun, S | 1 |
| Gustin, SM | 1 |
| McAuley, JH | 2 |
| Lee, H | 1 |
| O'Hagan, E | 1 |
| Furlan, AD | 2 |
| van Tulder, MW | 1 |
| Fowler, C | 1 |
| Chu, AW | 1 |
| Guo, N | 1 |
| Ansari, JR | 1 |
| Shafer, SL | 1 |
| Flood, PD | 1 |
| Ben Othman, A | 1 |
| Ben Ali, R | 1 |
| Ben Akacha, A | 1 |
| El May, MV | 1 |
| Diaz Martinez, JP | 1 |
| Qureshi, I | 1 |
| Abdulrashid, K | 1 |
| Thomas, SH | 1 |
| Abdel-Rahman, ME | 1 |
| Pathan, SA | 1 |
| Harris, T | 1 |
| Leiva-Vásquez, O | 1 |
| Pérez-Cruz, PE | 1 |
| Tiwaskar, M | 1 |
| Muruganathan, A | 1 |
| Gondane, A | 1 |
| Pawar, D | 1 |
| Jones, J | 1 |
| Correll, DJ | 1 |
| Lechner, SM | 1 |
| Jazic, I | 1 |
| Miao, X | 1 |
| Shaw, D | 1 |
| Simard, C | 1 |
| Osteen, JD | 1 |
| Hare, B | 1 |
| Beaton, A | 1 |
| Bertoch, T | 1 |
| Buvanendran, A | 1 |
| Habib, AS | 1 |
| Pizzi, LJ | 1 |
| Pollak, RA | 1 |
| Weiner, SG | 1 |
| Bozic, C | 1 |
| Negulescu, P | 1 |
| White, PF | 1 |
| Aghaloo, T | 1 |
| Claytor, JW | 1 |
| Dhar, V | 1 |
| Dionne, RA | 1 |
| Espinoza, L | 1 |
| Gordon, SM | 1 |
| Law, AS | 1 |
| Li, BS | 1 |
| Schwartz, PJ | 1 |
| Suda, KJ | 1 |
| Turturro, MA | 1 |
| Wright, ML | 1 |
| Dawson, T | 1 |
| Pahlke, S | 1 |
| Pilcher, L | 1 |
| Shirey, M | 1 |
| Vilcane, S | 1 |
| Scharonow, O | 1 |
| Weilbach, C | 1 |
| Scharonow, M | 1 |
| Schreijenberg, M | 3 |
| Lin, CC | 3 |
| Williams, CM | 4 |
| Kamper, SJ | 1 |
| Koes, BW | 3 |
| Billot, L | 2 |
| Mercadante, S | 1 |
| Voza, A | 1 |
| Serra, S | 1 |
| Ruggiano, G | 1 |
| Carpinteri, G | 1 |
| Gangitano, G | 1 |
| Intelligente, F | 1 |
| Bonafede, E | 1 |
| Sblendido, A | 1 |
| Farina, A | 1 |
| Soldi, A | 1 |
| Fabbri, A | 1 |
| Chertoff, A | 2 |
| Solorzano, C | 1 |
| Zias, E | 1 |
| Gallagher, EJ | 5 |
| Chiarotto, A | 1 |
| Mauff, KAL | 1 |
| Blok, Z | 1 |
| Ridderikhof, ML | 1 |
| Goddijn, H | 1 |
| Berendsen, M | 1 |
| Hollmann, MW | 1 |
| Bijur, PE | 7 |
| White, D | 3 |
| Wollowitz, A | 1 |
| Campbell, C | 2 |
| Jones, MP | 1 |
| Motov, S | 3 |
| Butt, M | 2 |
| Masoudi, A | 2 |
| Palacios, W | 1 |
| Fassassi, C | 2 |
| Drapkin, J | 2 |
| Likourezos, A | 2 |
| Hossain, R | 1 |
| Brady, J | 1 |
| Rothberger, N | 1 |
| Flom, P | 1 |
| Zerzan, J | 1 |
| Marshall, J | 1 |
| Thybo, KH | 1 |
| Hägi-Pedersen, D | 1 |
| Wetterslev, J | 1 |
| Overgaard, S | 1 |
| Mathiesen, O | 2 |
| Mazer-Amirshahi, M | 1 |
| Nelson, LS | 2 |
| Antill, AC | 1 |
| Frye, SW | 1 |
| McMillen, JC | 1 |
| Haynes, JC | 1 |
| Ford, BR | 1 |
| Bollig, RW | 1 |
| Daley, BJ | 1 |
| Busse, JW | 1 |
| Sadeghirad, B | 1 |
| Oparin, Y | 1 |
| Chen, E | 1 |
| Goshua, A | 1 |
| May, C | 1 |
| Hong, PJ | 1 |
| Agarwal, A | 1 |
| Chang, Y | 1 |
| Ross, SA | 1 |
| Emary, P | 1 |
| Florez, ID | 1 |
| Noor, ST | 1 |
| Yao, W | 1 |
| Lok, A | 1 |
| Ali, SH | 1 |
| Craigie, S | 1 |
| Couban, R | 1 |
| Morgan, RL | 1 |
| Culig, K | 1 |
| Brar, S | 1 |
| Akbari-Kelachayeh, K | 1 |
| Pozdnyakov, A | 1 |
| Shergill, Y | 1 |
| Sivananthan, L | 1 |
| Zihayat, B | 1 |
| Das, A | 1 |
| Guyatt, GH | 1 |
| Koes, B | 1 |
| Tkachev, A | 1 |
| Ghamry, NK | 1 |
| Ali, AS | 1 |
| Shareef, MA | 1 |
| AlAmodi, AA | 1 |
| Hamza, M | 1 |
| Abbas, AM | 1 |
| Fadlalmola, HA | 1 |
| Alalfy, M | 1 |
| Mahmoud, AO | 1 |
| Islam, Y | 1 |
| Schectman, JM | 1 |
| Dove, D | 1 |
| Davis, A | 1 |
| Gohel, A | 1 |
| Silver, M | 1 |
| Pergolizzi, JV | 2 |
| Magnusson, P | 1 |
| LeQuang, JA | 1 |
| Breve, F | 1 |
| Taylor, R | 2 |
| Wollmuth, C | 1 |
| Varrassi, G | 1 |
| Bebee, B | 1 |
| Taylor, DM | 1 |
| Bourke, E | 1 |
| Pollack, K | 1 |
| Foster, L | 1 |
| Ching, M | 1 |
| Wong, A | 1 |
| Yuan, H | 1 |
| Chang, QY | 1 |
| Chen, J | 1 |
| Wang, YT | 1 |
| Gan, ZJ | 1 |
| Wen, S | 1 |
| Li, TT | 1 |
| Xiong, LL | 1 |
| Gottlieb, IJ | 1 |
| Gilchrist, N | 1 |
| Carson, S | 1 |
| Stanescu, I | 2 |
| Atkinson, H | 1 |
| Kaye, AD | 1 |
| Cornett, EM | 1 |
| Helander, E | 1 |
| Menard, B | 1 |
| Hsu, E | 1 |
| Hart, B | 1 |
| Brunk, A | 1 |
| Milani, GP | 1 |
| Benini, F | 1 |
| Dell'Era, L | 1 |
| Podestà, AF | 1 |
| Mancusi, RL | 1 |
| Fossali, EF | 1 |
| Esses, D | 1 |
| Barnaby, DP | 2 |
| Baer, J | 1 |
| Visconti, A | 1 |
| Gren, C | 1 |
| Vogler, K | 1 |
| Miranda, M | 1 |
| Debes, NM | 1 |
| Miki, K | 1 |
| Ikemoto, T | 1 |
| Hayashi, K | 1 |
| Arai, YC | 1 |
| Sekiguchi, M | 1 |
| Shi, K | 1 |
| Ushida, T | 1 |
| Ziegler, KM | 1 |
| Lipman, RD | 1 |
| Aminoshariae, A | 1 |
| Mariotti, A | 1 |
| Weingarten, TN | 1 |
| Taenzer, AH | 1 |
| Elkassabany, NM | 1 |
| Le Wendling, L | 1 |
| Nin, O | 1 |
| Kent, ML | 1 |
| Poddighe, D | 1 |
| Brambilla, I | 1 |
| Licari, A | 1 |
| Marseglia, GL | 1 |
| Narang, S | 1 |
| Koli, J | 1 |
| Krishna, SN | 1 |
| Chauhan, S | 1 |
| Bhoi, D | 1 |
| Kaushal, B | 1 |
| Hasija, S | 1 |
| Sangdup, T | 1 |
| Bisoi, AK | 1 |
| Ata, A | 1 |
| Pearlman, S | 2 |
| Restivo, A | 1 |
| Chertoff, AE | 1 |
| Restivo, AJ | 1 |
| Campbell, CM | 1 |
| van Uum, RT | 1 |
| Venekamp, RP | 1 |
| Sjoukes, A | 1 |
| van de Pol, AC | 1 |
| de Wit, GA | 1 |
| Schilder, AGM | 1 |
| Damoiseaux, RAMJ | 1 |
| Daniels, SE | 2 |
| Atkinson, HC | 1 |
| Frampton, C | 1 |
| Bouida, W | 1 |
| Beltaief, K | 1 |
| Msolli, MA | 1 |
| Ben Marzouk, M | 1 |
| Boubaker, H | 1 |
| Grissa, MH | 1 |
| Zorgati, A | 1 |
| Methamem, M | 1 |
| Boukef, R | 1 |
| Belguith, A | 1 |
| Nouira, S | 1 |
| Koyuncu, O | 1 |
| Hakimoglu, S | 1 |
| Ugur, M | 1 |
| Akkurt, C | 1 |
| Turhanoglu, S | 1 |
| Sessler, D | 1 |
| Turan, A | 1 |
| Rokyta, R | 1 |
| Lejčko, J | 1 |
| Houdek, K | 1 |
| Trefil, L | 1 |
| Nedvídek, J | 1 |
| Fricová, J | 1 |
| Holeček, V | 1 |
| Zuniga, JR | 1 |
| Papas, AS | 1 |
| Patrick, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Maxigesic IV Bunionectomy Study- A Phase 3, Randomized, Double-Blind, Multiple-Dose, Parallel-Group and Placebo-Controlled Study[NCT02689063] | Phase 3 | 276 participants (Actual) | Interventional | 2016-10-26 | Completed | ||
| Randomized Double-blind Controlled Study to Assess the Efficacy of Intravenous Acetaminophen Associated With Strong Opioids in the Management of Acute Pain in Adult Cancer Patients[NCT04779567] | Phase 4 | 112 participants (Actual) | Interventional | 2019-06-10 | Completed | ||
| Efficacy and Safety of Methoxyflurane Vaporized (PENTHROX®) in the Treatment of Acute Trauma Pain in Pre-hospital Setting and in the Emergency Department in Italy: a Multicentre, Randomized, Controlled, Open-label Study[NCT03585374] | Phase 3 | 272 participants (Actual) | Interventional | 2018-02-08 | Completed | ||
| The Randomized Double-Blind Comparison of Analgesic Efficacy Between Intravenous Forms of Ibuprofen 400 and Ibuprofen 800 mg in Acute Mechanical Low Back Pain in the Emergency Department[NCT06064175] | Phase 4 | 144 participants (Actual) | Interventional | 2022-01-01 | Completed | ||
| Oral Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Pain Reduction in Children[NCT04630834] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-03-30 | Recruiting | ||
| Management Of Pain After Cesarean Trial[NCT03929640] | Phase 3 | 49 participants (Actual) | Interventional | 2019-08-05 | Completed | ||
| Comparative Efficacy of 4 Oral Analgesics for the Initial Management of Acute Musculoskeletal Extremity Pain[NCT02455518] | Phase 4 | 416 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Oxycodone or Ibuprofen for Suspected Isolated Forearm Fractures in Pediatric Patients: A Randomized Noninferiority Trial[NCT04523623] | 200 participants (Anticipated) | Interventional | 2020-09-30 | Not yet recruiting | |||
| Achieving Peri-Operative Pain Control Without Opioids[NCT04813991] | Phase 3 | 0 participants (Actual) | Interventional | 2022-03-15 | Withdrawn (stopped due to Enrollment was never initiated and the PI is leaving the institution so the study is closing.) | ||
| Does Bilateral Continuous Peri Operative Erector Spinae Plane Block Improve The Enhanced Recovery Program After Open Heart Surgeries in Adults?[NCT04506762] | 20 participants (Actual) | Interventional | 2020-11-01 | Terminated (stopped due to Surgical team resigned from our hospital) | |||
| Erector Spinae Plane Block Versus Intrapleural Intercostal Plane Block for Post-thoracotomy Pain: a Randomized Trial[NCT04013815] | 60 participants (Actual) | Interventional | 2019-08-01 | Completed | |||
| Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population[NCT04298099] | Phase 4 | 24 participants (Anticipated) | Interventional | 2020-12-17 | Recruiting | ||
| Errector Spinae Plane Block for Postoperative Pain Management in Cardiac Surgery: A Randomized Controlled Trial[NCT04420104] | 40 participants (Anticipated) | Interventional | 2020-06-01 | Recruiting | |||
| Effects of Erector Spinae Plane Block on Sympathectomy in Off Pump Coronary Artery Bypass Surgery[NCT04447560] | 25 participants (Actual) | Interventional | 2020-07-06 | Completed | |||
| Erector Spinae Plane Block in Patients Undergoing Minimally Invasive Lumbar Spine Surgery: A Randomized Controlled Trial[NCT05856539] | 48 participants (Anticipated) | Interventional | 2023-05-15 | Recruiting | |||
| Acetaminophen 1g IV vs Hydromorphone 1mg IV for the Treatment of Acute Pain in the Emergency Department[NCT03107481] | Phase 4 | 220 participants (Actual) | Interventional | 2017-06-04 | Completed | ||
| Maxigesic 325 Acute Dental Pain Study: A Double-blind, Placebo-controlled, Randomized, Parallel Group Comparison of the Effects of Maxigesic 325 Versus Acetaminophen, Ibuprofen and Placebo in Participants With Acute Dental Pain[NCT01420653] | Phase 3 | 408 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| A Prospective, Randomized Trial of the Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post Operative Opioid Use Disorder Symptoms[NCT03266445] | Phase 4 | 76 participants (Anticipated) | Interventional | 2018-10-05 | Not yet recruiting | ||
| Efficiency And Quality In Post-Surgical Pain Therapy After Discharge[NCT05221866] | 711 participants (Actual) | Interventional | 2022-03-14 | Completed | |||
| UControlPain App (This is the Official IRB Title)[NCT03833648] | 60 participants (Actual) | Interventional | 2019-06-19 | Completed | |||
| Effect of Paracetamol and Ibuprofen When Intravenously Given Combination or Alone in Reducing Morphine Requirements After Total Knee Arthroplasty[NCT04414995] | Phase 2/Phase 3 | 36 participants (Actual) | Interventional | 2020-06-05 | Completed | ||
| Demonstration of OTC Naproxen Sodium's (Aleve's) Anti-inflammatory Action in Dental Implant Surgery Patients[NCT04694300] | Phase 4 | 32 participants (Actual) | Interventional | 2021-02-07 | Completed | ||
| A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Evaluation of the Safety and Analgesic Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain Followed by an Open-Label Extension[NCT01484652] | Phase 3 | 329 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Opioid-Free Shoulder Arthroplasty[NCT03540030] | Phase 4 | 86 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Efficacy and Side Effects of Intrathecal Morphine in Multimodal Analgesia for Unilateral Total Knee Arthroplasty[NCT03232957] | 131 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| A Randomized, Active-Controlled, Parallel Group, Double-Blind Study to Compare the Efficacy and Safety of Tramadol HCl/Acetaminophen ER and IR in Subjects Who Complain of Moderate to Severe Postoperative Pain[NCT01814878] | Phase 3 | 320 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02596815] | 51 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02595294] | 52 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen as Adjuvant, Postoperative Pain After Herniated Disc Surgery[NCT01953978] | Phase 4 | 160 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Short-term Effectiveness of Additional Electrical Stimulation to Exercise Versus Kinesio Taping in Patients With Chronic Low Back Pain: A Randomized Controlled Trial[NCT02812459] | 62 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| The Effect of Kinesio Taping and Breathing Exercises on Pain Management Applied After Benign Gynecological Abdominal Operation: A Randomized Controlled Study[NCT04412122] | 132 participants (Actual) | Interventional | 2017-06-01 | Completed | |||
| Aromatherapy for Management of Back Pain in the Emergency Department[NCT03377088] | 60 participants (Anticipated) | Interventional | 2017-12-11 | Recruiting | |||
| Onset of Action of a Fast Release Aspirin Tablet and Acetaminophen Caplet in Sore Throat Pain[NCT01453400] | Phase 3 | 177 participants (Actual) | Interventional | 2011-09-27 | Completed | ||
| Comparative Onset of Action of a Fast Release Aspirin Tablet in a Dental Impaction Pain Model[NCT01420094] | Phase 3 | 510 participants (Actual) | Interventional | 2011-06-16 | Completed | ||
| A Combination Study With Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain in the Emergency Department[NCT03959852] | Phase 4 | 6 participants (Actual) | Interventional | 2019-11-18 | Terminated (stopped due to Residency completed.) | ||
| Trigger Point Injection for Myofascial Pain Syndrome in the Low Back (T-PIMPS): A Randomized Controlled Trial.[NCT04704297] | Phase 4 | 180 participants (Anticipated) | Interventional | 2020-12-28 | Recruiting | ||
| Electroacupuncture Frequency-related Effects on Chronic Low Back Pain in Older Adults: Triple-blind, 12-month Protocol for a Randomized Controlled Trial.[NCT03802045] | 125 participants (Anticipated) | Interventional | 2019-05-01 | Recruiting | |||
| Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries[NCT04199572] | Phase 4 | 162 participants (Actual) | Interventional | 2022-10-16 | Completed | ||
| Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567] | 42 participants (Actual) | Interventional | 2021-03-12 | Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.) | |||
| The Effects of Spinal Manipulative Therapy on Postactivation Potentiation[NCT02848456] | 20 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| The Influence of the Sacroiliac Joint Manipulation on Changes in the Values of the Center of Pressure in the Process of Maintaining Static Body Balance[NCT04387032] | 59 participants (Actual) | Interventional | 2019-06-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"A Pain Intensity Difference (PID) is the difference between the Visual Analogue Scale (VAS) pain intensity score recorded at baseline and a score recorded at any time after the first dose of study medication. Taken together, a patient's PID scores capture the pain relief profile attributable to the assigned study medication. A high PID score indicates a better pain relief experienced.~The extent of pain relief can then be calculated by the Area Under the Curve the PID scores (also referred to as the Sum of Pain Intensity Differences [SPID]). SPID48 scores were adjusted by the time interval from baseline to the final VAS score used in the SPID, using the following formula:~Time-adjusted SPID48 (mm) = SPID (mm*hr) / Time (hr) In the event that a patient required rescue medication, the SPID was calculated up until the first Pre-Rescue VAS pain assessment (inclusive)." (NCT02689063)
Timeframe: 48 hours after the first dose
| Intervention | score on a scale (Mean) |
|---|---|
| Maxigesic IV | 23.4 |
| IV Acetaminophen | 10.4 |
| IV Ibuprofen | 9.5 |
| Placebo IV | -1.3 |
"At the end of 48 hours study period, participants will be asked to How do you rate the study medication? on a 5 point categorical scale:~Poor~Fair~Good~Very Good~Excellent The high score means the participants believed that a better treatment for pain relief received." (NCT02689063)
Timeframe: 48 hrs after the first dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Maxigesic IV | 24 |
| IV Acetaminophen | 5 |
| IV Ibuprofen | 8 |
| Placebo IV | 1 |
"VAS Pain intensity difference (PID) at each scheduled assessment time point after Time 0.~A Pain Intensity Difference (PID) is the difference between the Visual Analogue Scale (VAS) pain intensity score recorded at baseline and a score recorded at any time after the first dose of study medication. Taken together, a patient's PID scores capture the pain relief profile attributable to the assigned study medication. A high PID score indicates a better pain relief experienced." (NCT02689063)
Timeframe: 48 hours after the first dose
| Intervention | score on a scale (Mean) |
|---|---|
| Maxigesic IV | 52.50 |
| IV Acetaminophen | 38.95 |
| IV Ibuprofen | 45.04 |
| Placebo IV | 37.24 |
"VAS Pain intensity score at each scheduled assessment time point VAS pain intensity score-marking on a 100 mm VAS scale with anchors for no pain (0 mm) and worst pain imaginable (100 mm). A high VAS score indicates a more intensive pain level experienced." (NCT02689063)
Timeframe: 48 hours after the first dose
| Intervention | score on a scale (Mean) |
|---|---|
| Maxigesic IV | 18.43 |
| IV Acetaminophen | 29.28 |
| IV Ibuprofen | 27.21 |
| Placebo IV | 28.22 |
Treatment-emergent Adverse events coded to MedDRA v 20.0 Preferred Term and System Organ Class Code were tabulated as the counts and percentages by treatment group. (NCT02689063)
Timeframe: Day 7
| Intervention | Participants (Count of Participants) |
|---|---|
| Maxigesic IV | 52 |
| IV Acetaminophen | 45 |
| IV Ibuprofen | 58 |
| Placebo IV | 39 |
"Peak Pain Relief was assessed on Pain Relief scores (on a 5 point categorical rating-please see outcome measure description No. 7) recorded up until the first dose of rescue (First Pre-Rescue Pain Relief score inclusive).~The percentage of participants who achieve the peak pain relief was summarized." (NCT02689063)
Timeframe: 48 hours after the first dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Maxigesic IV | 22 |
| IV Acetaminophen | 11 |
| IV Ibuprofen | 4 |
| Placebo IV | 3 |
"Pain relief score was assessed on a 5-point categorical scale at each scheduled time point after Time 0:~0 = No pain relief (the pain is the same, or worse, than the starting pain)~= A little pain relief (the pain is less than half gone)~= some pain relief (the pain is about half gone)~= A lot pain relief (the pain is more than half gone)~= Complete pain relief (the pain is completely gone)~Assessed at scheduled time points:~5, 10, 15, 30, 45 minutes, 1, 1.5, 2, 3, 4, 5, 6 hours after the first dose of the study drug~Immediately before and 2 hours after each subsequent dose (doses 2-8) of the study drug while awake~At the end of 48 hours of double-blind treatment period~Immediately before taking each dose of the rescue medication if additional analgesia is required.~At the time of withdrawal (if applicable)" (NCT02689063)
Timeframe: 48 hours after the first dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Maxigesic IV | 29 |
| IV Acetaminophen | 7 |
| IV Ibuprofen | 16 |
| Placebo IV | 4 |
The percentage of participants who used at lease one dose of rescue medication was summarized in each treatment group (NCT02689063)
Timeframe: 48 hrs after the first dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Maxigesic IV | 56 |
| IV Acetaminophen | 70 |
| IV Ibuprofen | 70 |
| Placebo IV | 48 |
"Time to peak pain relief-Peak Pain Relief was assessed on Pain Relief scores recorded up until the first dose of rescue (First Pre-Rescue Pain Relief score inclusive). Time for participants who experienced peak pain relief was summarized.~Note: For the reader to interpret this outcome measure, a very short Time to Peak Pain Relief indicates the absence of analgesic effect for a treatment because peak pain relief was determined prior to the first dose of rescue medication (or 48 hours if no rescue medication was used)." (NCT02689063)
Timeframe: 48 hrs after the first dose
| Intervention | hours (Mean) |
|---|---|
| Maxigesic IV | 4.00 |
| IV Acetaminophen | 2.46 |
| IV Ibuprofen | 1.47 |
| Placebo IV | 0.91 |
Time to first use of rescue medication (duration of analgesia) (NCT02689063)
Timeframe: 48 hrs
| Intervention | hours (Mean) |
|---|---|
| Maxigesic IV | 12.98 |
| IV Acetaminophen | 5.62 |
| IV Ibuprofen | 3.09 |
| Placebo IV | 2.92 |
"Two-stopwatch method~Start two stopwatches ('Stopwatch A' and 'Stopwatch B') at the same time that the infusion of study drug is initiated. This is Time 0.~The participant is given 'Stopwatch A' and instructed to Stop 'Stopwatch A' when you first feel any pain relief whatsoever. This does not mean you feel completely better, although you might, but when you first feel any relief in the pain you have now. (Perceptible Pain Relief)~When the participant stops the 'Stopwatch A', the participant then was asked Do you consider the pain relief you experienced meaningful?~If the participant answered No, then the participant was given the Stopwatch B and instructed to Stop 'Stopwatch B' when you feel the pain relief is meaningful to you (Meaningful Pain Relief)~If the subject did not experience perceptible pain relief, they would retain 'Stopwatch A' for the entire 6 hour evaluation period." (NCT02689063)
Timeframe: 6 hours
| Intervention | minutes (Median) |
|---|---|
| Maxigesic IV | 9.4 |
| IV Acetaminophen | 23.9 |
| IV Ibuprofen | 13.8 |
| Placebo IV | 0 |
"Time adjusted SPID-6, SPID-12, SPID-24 were derived in a similar manner to the Time-adjusted SPID-48 (i.e. up until the first Pre-Rescue VAS inclusive). Please see the primary outcome measure descriptions.~Each of these variables were derived from VAS (Visual Analogue Scale) scores recorded prior to the first dose of rescue medication in the first 6 (to calculate SPID6), 12 (to calculate SPID12) or 24 hours (to calculate SPID24) of the study.~VAS pain intensity scores were obtained by marking on a 100 mm VAS scale with anchors for no pain (0 mm) and worst pain imaginable (100 mm). The VAS was completed at rest." (NCT02689063)
Timeframe: 6, 12, 24 hours after the first dose
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| SPID 6 | SPID 12 | SPID 24 | |
| IV Acetaminophen | 10.13 | 9.42 | 9.59 |
| IV Ibuprofen | 9.01 | 8.44 | 8.64 |
| Maxigesic IV | 20.10 | 20.63 | 21.99 |
| Placebo IV | -1.49 | -1.66 | -1.54 |
Total use of rescue analgesia over 0 to 24 hours and over 0 to 48 hours (NCT02689063)
Timeframe: 24, 48 hrs after the first dose
| Intervention | mg (Mean) | |
|---|---|---|
| Total Dose in 48 hrs | Total Dose in 24 hrs | |
| IV Acetaminophen | 33.1 | 23.7 |
| IV Ibuprofen | 32.4 | 22.1 |
| Maxigesic IV | 22.9 | 17.2 |
| Placebo IV | 44.7 | 29.6 |
"Total Pain Relief (TOTPAR) is a measure of total Area Under the Curve of Pain Relief scores. In the event that a patient required rescue medication, the TOTPAR endpoints were calculated using Pain Relief Assessments recorded prior to the first dose of rescue (i.e. inclusive of the first pre-rescue Pain Relief score).~Pain relief scores were obtained by marking on a 5-point categorical rating at scheduled time points.~The high score means more pain relief experienced:~0 = No pain relief (the pain is the same, or worse, than the starting pain)~= A little pain relief (the pain is less than half gone)~= some pain relief (the pain is about half gone)~= A lot pain relief (the pain is more than half gone)~= Complete pain relief (the pain is completely gone) Each of these variables were derived from pain relief scores recorded prior to the first dose of rescue medication in the first 6 (0-48), 12 (0-48), 24 (0-48) or 48 (0-48) hours of the study." (NCT02689063)
Timeframe: 6, 12, 24, 48 hours after the first dose
| Intervention | score on a scale*hour (Mean) | |||
|---|---|---|---|---|
| TOTPAR 6 | TOTPAR 12 | TOTPAR 24 | TOTPAR 48 | |
| IV Acetaminophen | 4.59 | 6.74 | 8.66 | 13.28 |
| IV Ibuprofen | 3.34 | 4.46 | 6.51 | 11.95 |
| Maxigesic IV | 6.84 | 11.86 | 22.13 | 43.98 |
| Placebo IV | 1.60 | 1.82 | 2.49 | 4.51 |
Change in numerical rating scale (NRS) pre and 1-hour post receiving study medication while in the ED. The NRS is a validated 11-point numerical scale that ranges from 0 (no pain) to 10 (worst pain possible) (NCT02455518)
Timeframe: 1 hour
| Intervention | units on a scale (Number) |
|---|---|
| Oxycodone/Acetaminophen | 3.1 |
| Hydrocodone/Acetaminophen | 2.4 |
| Codeine/Acetaminophen | 2.7 |
| Ibuprofen/Acetaminophen | 2.9 |
Change in numerical rating scale (NRS) pre and 2 hours post receiving study medication while in the ED. The NRS is a validated 11-point numerical scale that ranges from 0 (no pain) to 10 (worst pain possible) (NCT02455518)
Timeframe: 2 hours
| Intervention | units on a scale (Number) |
|---|---|
| Oxycodone/Acetaminophen | 4.4 |
| Hydrocodone/Acetaminophen | 3.5 |
| Codeine/Acetaminophen | 3.9 |
| Ibuprofen/Acetaminophen | 4.3 |
"The time-adjusted Summed Pain Intensity Differences (SPIDs) of the VAS pain intensity scores up to 48 hours after the first dose of study medication.~This was calculated from the visual analogue scale (VAS) pain intensity scores recorded during the 48 hours double blind treatment period, with the last measure taken just prior to the final dose of blinded study medication. The visual analogue scale is 100mm long with 0= no pain and 100=worst pain imaginable. The Visual Analogue Scale It is expected that treatments which can provide superior analgesic effect will demonstrate a greater Summed Pain Intensity Difference." (NCT01420653)
Timeframe: 48 hours afte the first dose
| Intervention | score on a scale (Mean) |
|---|---|
| Maxigesic 325 | 31.56 |
| Acetaminophen | 17.71 |
| Ibuprofen | 23.18 |
| Placebo | 14.86 |
Pain intensity (PI) is measured using the 11-point (0-10) Numeric Pain Rating Scale (NPRS) score. PID is the arithmetic difference in NPRS score at the time point of interest from the baseline score. SPID48 is the sum of time-weighted PID scores measured 22 times over the 48 hour assessment period, with a total score ranging from -480 (worst) to 480 (best). A higher SPID value indicates greater pain relief. (NCT01484652)
Timeframe: 48 hours
| Intervention | scores on a scale (Mean) |
|---|---|
| COV795 | 114.9 |
| Placebo | 66.9 |
American Shoulder and Elbow Surgeons (ASES) Shoulder Score for pain and function. Range 0-100. Low score = worse shoulder condition. Function, disability, and pain subscores (all ranges 0-50), and are summed for total ASES score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | units on a scale (Median) |
|---|---|
| Observational | 54.3 |
| Non-Opioid Intervention | 54.2 |
Morphine milli-equivalents In-hospital post-operative. Continuous scale of MME, no defined better/worse. Measured as number and dose of medications taken. For example, if the patient received an opioid, the drug and dose was recorded and converted to MME. A time frame of when to assess opioid use in-hospital post-operative was not used but was a continuous monitor for rescue opioid from in-hospital post-operative through discharge. (NCT03540030)
Timeframe: In-hospital Stay
| Intervention | Morphine milli-equivalents (Median) |
|---|---|
| Observational | 45.0 |
| Non-Opioid Intervention | 19.0 |
Pain at patient discharge or 24-hours, whichever comes first - measured on a 0 (no pain) -10 (worst possible pain) numeric rating scale (NRS). A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 3.0 |
| Non-Opioid Intervention | 2.0 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 6 |
| Non-Opioid Intervention | 6 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 2.0 |
| Non-Opioid Intervention | 2.0 |
post-operative pain: measured on a 0 (no pain) -10 (worst) numeric rating scale (NRS) at 6hrs, 12hrs, 2 weeks, and 2 months. A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 6hrs, 12hrs, 2weeks, 2 months
| Intervention | score on a scale (Median) | |||
|---|---|---|---|---|
| 6 Hrs | 12 hrs | 2 weeks | 2 months | |
| Non-Opioid Intervention | 0.0 | 0 | 0.82 | 0 |
| Observational | 2 | 4 | 1.3 | 0.7 |
rate of constipation (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 7 | 21 | 2 |
rate of constipation (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 13 | 22 | 0 |
| Observational | 19 | 9 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 4 | 24 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 5 | 30 | 0 |
| Observational | 1 | 27 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 30 | 0 |
| Observational | 0 | 28 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 34 | 0 |
| Observational | 5 | 23 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 29 | 2 | 4 |
| Observational | 23 | 5 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 34 | 1 | 0 |
| Observational | 27 | 1 | 2 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 40.3 | 60.8 |
| Observational | 38.4 | 58.7 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 35.0 | 59.1 |
| Observational | 36.7 | 56.3 |
The dosage of the rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief was measured after administration of the study drug. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular or intravenous injection). (NCT01814878)
Timeframe: Baseline up to Day 3
| Intervention | Milligram (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 50.0 |
| Tramadol HCl/Acetaminophen IR | 51.7 |
The frequency of the rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief was measured after administration of the study drug. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular or intravenous injection). (NCT01814878)
Timeframe: Baseline up to Day 3
| Intervention | Doses (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 2.1 |
| Tramadol HCl/Acetaminophen IR | 1.4 |
The PGIC was used to assess the degree of participant's overall improvement with treatment, and participants were instructed to assess how much the overall status had been improved after investigational product administration compared to baseline in 7 grades (1=Very much improved and B=Very much worsened). (NCT01814878)
Timeframe: Day 3
| Intervention | Units on scale (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 2.71 |
| Tramadol HCl/Acetaminophen IR | 2.60 |
The SPID is time-weighted sum of all observations of pain intensity difference (PID) collected at each measurement time point from Baseline to 48 hours. PID: Baseline pain intensity (PI) minus current PI; PI was assessed using 11-point numeric rating scale (NRS, 0=no pain to 10=worst pain imaginable). PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <=3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. Total score for SPID at 48 hours (SPID48) ranges from -144 (worst) to 144 (best). (NCT01814878)
Timeframe: Hour 48
| Intervention | Units on scale (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 32.5 |
| Tramadol HCl/Acetaminophen IR | 37.2 |
The time until administration of the first rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief after administration of the study drug was recorded. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular [directly into muscle] or intravenous injection [directly into vein]). (NCT01814878)
Timeframe: Baseline up to Day 3
| Intervention | Minutes (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 1339 |
| Tramadol HCl/Acetaminophen IR | 1212 |
The SPID is time-weighted sum of all observations of PID collected at each measurement time point from Baseline to 24 hours. PID: Baseline PI minus current PI; PI was assessed using 11-point NRS, 0=no pain to 10=worst pain imaginable. PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <=3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. Total score ranges from -18 (worst) to 18 (best) for SPID6, -36 (worst) to 36 (best) for SPID12 and -72 (worst) to 72 (best) for SPID24. (NCT01814878)
Timeframe: Hour 6, 12, 24
| Intervention | Units on scale (Mean) | ||
|---|---|---|---|
| Hour 6 | Hour 12 | Hour 24 | |
| Tramadol HCl/Acetaminophen IR | 3.9 | 8.1 | 17.6 |
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 3.6 | 7.0 | 14.6 |
The SPRID is sum of SPID and TOTPAR. In SPID, PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <= 3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. In TOTPAR, pain relief score ranges from 0-4 (0=no change, 1=slight relief, 2=moderate relief, 3=fair relief, 4=pain resolved completely). Total score ranges from -18 (worst) to 42 (best) for SPRID6, -36 (worst) to 84 (best) for SPRID12, -72 (worst) to 168 (best) for SPRID24 and -144 (worst) to 336 (best) for SPRID48. (NCT01814878)
Timeframe: Hour 6, 12, 24, 48
| Intervention | Units on scale (Mean) | |||
|---|---|---|---|---|
| Hour 6 | Hour 12 | Hour 24 | Hour 48 | |
| Tramadol HCl/Acetaminophen IR | 10.9 | 23.1 | 49.1 | 97.0 |
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 9.6 | 19.6 | 41.8 | 85.9 |
Pain relief was measured on a 5-point categorical scale of 0-4 (0=no change, 1=slight relief, 2=moderate relief, 3=fair relief, 4=pain resolved completely). TOTPAR was calculated as the time-weighted sum over all pain relief up to 48 hours. Total score ranges from 0 (worst) to 24 (best) for TOTPAR6, 0 (worst) to 48 (best) for TOTPAR12, 0 (worst) to 96 (best) for TOTPAR24 and 0 (worst) to 192 (best) for TOTPAR48. (NCT01814878)
Timeframe: Hour 6, 12, 24, 48
| Intervention | Units on scale (Mean) | |||
|---|---|---|---|---|
| Hour 6 | Hour 12 | Hour 24 | Hour 48 | |
| Tramadol HCl/Acetaminophen IR | 6.8 | 14.7 | 31.0 | 61.7 |
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 6.0 | 12.5 | 27.1 | 55.6 |
38 reviews available for acetaminophen and Acute Pain
| Article | Year |
|---|---|
Single-dose intravenous ibuprofen for acute postoperative pain in adults.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Femal | 2021 |
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
Topics: Acetaminophen; Acute Pain; Episiotomy; Female; Humans; Infant, Newborn; Perineum; Postpartum Period; | 2021 |
Nonopioid Analgesics for the Perioperative Geriatric Patient: A Narrative Review.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2022 |
Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease, gastrointestinal disorders, asthma, or who are older.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Asthma; Cardiovascular | 2022 |
Medications for Treating Low Back Pain in Adults. Evidence for the Use of Paracetamol, Opioids, Nonsteroidal Anti-inflammatories, Muscle Relaxants, Antibiotics, and Antidepressants: An Overview for Musculoskeletal Clinicians.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Anti-Bacterial Agents; Anti-Inflammatory Agent | 2022 |
Acute Postoperative Pain Due to Dental Extraction in the Adult Population: A Systematic Review and Network Meta-analysis.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Human | 2023 |
Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review.
Topics: Acetaminophen; Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Low Back Pain | 2023 |
Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Female; Humans; Low Back Pain; Male; Network Meta-Anal | 2023 |
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bupre | 2023 |
Analgesics for the management of acute dental pain in the pediatric population: A systematic review and meta-analysis.
Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Non-Narcotic; Child; Humans; Ibuprofen; Pulpitis | 2023 |
Comparison of intravenous paracetamol (acetaminophen) to intravenously or intramuscularly administered non-steroidal anti-inflammatory drugs (NSAIDs) or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic re
Topics: Acetaminophen; Acute Disease; Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-S | 2023 |
Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Cen
Topics: Academies and Institutes; Acetaminophen; Acute Pain; American Dental Association; Anti-Inflammatory | 2023 |
Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries : A Systematic Review and Network Meta-analysis of Randomized Trials.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Administration, Topical; Analgesics, Opioid; Anti-I | 2020 |
Paracetamol for low back pain: the state of the research field.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Low Back Pain; Randomized | 2020 |
An Update on Nonopioids: Intravenous or Oral Analgesics for Perioperative Pain Management.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug T | 2017 |
[Headache in children and adolescents].
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Child; Diagnosis, Differential; Eme | 2018 |
Benefits and harms associated with analgesic medications used in the management of acute dental pain: An overview of systematic reviews.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inf | 2018 |
Ibuprofen for Pain Control in Children: New Value for an Old Molecule.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Child; Drug Therapy, Combination; E | 2019 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Drug Combinations; | 2013 |
Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug C | 2013 |
Pharmacologic therapy for acute pain.
Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammato | 2013 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Acute pain management in infants and children-Part 1: Pain pathways, pain assessment, and outpatient pain management.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child | 2014 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Ibuprofen | 2015 |
As required versus fixed schedule analgesic administration for postoperative pain in children.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesia; Analgesics; Analgesics, Opioid; Child; Child, Pres | 2015 |
A 46-year-old man with acute low-back pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Analgesics, Non-Narcotic; Dose-Response Relationshi | 2016 |
The Use of Intravenous Acetaminophen for Acute Pain in the Emergency Department.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adult; Analgesics; Emergency Service, Hospit | 2016 |
No Difference Between Oxycodone/Acetaminophen and Hydrocodone/Acetaminophen for Acute Extremity Pain.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Drug Combinations; Extremities; Humans; Hydrocodone; | 2016 |
The combination of non-selective NSAID 400 mg and paracetamol 1000 mg is more effective than each drug alone for treatment of acute pain. A systematic review.
Topics: Acetaminophen; Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Drug Synergism; Drug Therapy, Co | 2014 |
Advanced Concepts and Controversies in Emergency Department Pain Management.
Topics: Acetaminophen; Acute Pain; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agen | 2016 |
Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Child; Humans; Injections, Intravenous; Pain Measureme | 2016 |
[Analgesic drugs during pregnancy].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acute Pain; Analgesics; Analgesics, Opioid; Anticonvulsa | 2016 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Tramadol hydrochloride/acetaminophen combination for the relief of acute pain.
Topics: Acetaminophen; Acute Pain; Drug Combinations; Humans; Pain, Postoperative; Tramadol | 2011 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Caffeine; Chemotherapy, Adjuvant; Female; Headache; Hu | 2012 |
The role of intravenous acetaminophen in acute pain management: a case-illustrated review.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Synergism; Femal | 2012 |
[Skin ulcer pain].
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chroni | 2012 |
57 trials available for acetaminophen and Acute Pain
| Article | Year |
|---|---|
Oxycodone induced euphoria in ED patients with acute musculoskeletal pain. A secondary analysis of data from a randomized trial.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Double-Blind Method; Drug Combinations; Euphoria; Hum | 2022 |
Comparative evaluation of the effectiveness of intravenous paracetamol, dexketoprofen and ibuprofen in acute low back pain.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double | 2022 |
Intravenous acetaminophen does not reduce morphine use for pain relief in emergency department patients: A multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Emerge | 2022 |
Randomized double-blind controlled trial to assess the efficacy of intravenous acetaminophen associated with strong opioids in the treatment of acute pain in adult cancer patients: study protocol.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Analgesics, Opioid; Cancer Pain; Humans; Neoplasms; Qu | 2022 |
A Randomized Study of Intravenous Hydromorphone Versus Intravenous Acetaminophen for Older Adult Patients with Acute Severe Pain.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Humans; Hydromorphone; Treatment Outcome | 2022 |
Ultrasound-Guided Erector Spinae Block Versus Ultrasound-Guided Thoracic Paravertebral Block for Pain Relief in Patients With Acute Thoracic Herpes Zoster: A Randomized Controlled Trial.
Topics: Acetaminophen; Acute Pain; Antiviral Agents; Bupivacaine; Dexamethasone; Herpes Zoster; Humans; Midd | 2022 |
Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA).
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Analgesics, Opioid; Double-Blind Method; Eme | 2022 |
Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA).
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Analgesics, Opioid; Double-Blind Method; Eme | 2022 |
Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA).
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Analgesics, Opioid; Double-Blind Method; Eme | 2022 |
Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA).
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Analgesics, Opioid; Double-Blind Method; Eme | 2022 |
Association of
Topics: Acetaminophen; Acute Pain; Breast Neoplasms; Chronic Pain; Female; Humans; MicroRNAs; Neuralgia; Rec | 2023 |
Outpatient Treatment With Gabapentin in Women With Severe Acute Pain After Cesarean Delivery Is Ineffective: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Double-Blind Method; Female; Gabapentin; Humans; Ibup | 2023 |
Is Acetaminophen Beneficial in Patients With Cancer Pain Who are on Strong Opioids? A Randomized Controlled Trial.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Cancer Pain; Double-Blind M | 2023 |
Selective Inhibition of Na
Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Opioid; Double-Blind Method; Humans; Hydrocodone; | 2023 |
Paracetamol is ineffective for acute low back pain even for patients who comply with treatment: complier average causal effect analysis of a randomized controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Humans; Low Back Pa | 2019 |
Analgesic Efficacy, Practicality and Safety of Inhaled Methoxyflurane Versus Standard Analgesic Treatment for Acute Trauma Pain in the Emergency Setting: A Randomised, Open-Label, Active-Controlled, Multicentre Trial in Italy (MEDITA).
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adult; Analgesics; Anesthetics, Inhalation; | 2019 |
Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Low Back Pain: An Emergency Department-based Randomized Study.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Inferential reproduction analysis demonstrated that "paracetamol for acute low back pain" trial conclusions were reproducible.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Confidence Intervals; Early Termination | 2020 |
Randomized Clinical Trial of Intravenous (IV) Acetaminophen as an Adjunct to IV Hydromorphone for Acute Severe Pain in Emergency Department Patients.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Emerge | 2020 |
Comparison of Oral Ibuprofen and Acetaminophen with Either Analgesic Alone for Pediatric Emergency Department Patients with Acute Pain.
Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Non-Narcotic; Child; Double-Blind Method; Emergen | 2020 |
The PANSAID randomized clinical trial: A pre-planned 1-year follow-up regarding harm.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Denmark; Drug Therapy, Combination; Follow-Up S | 2020 |
Treatment With Oral Versus Intravenous Acetaminophen in Elderly Trauma Patients With Rib Fractures: A Prospective Randomized Trial.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Administration, Oral; Aged; Aged, 80 and ove | 2020 |
Efficacy and Safety of Intravenous Tramadol versus Intravenous Paracetamol for Relief of Acute Pain of Primary Dysmenorrhea: A Randomized Controlled Trial.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adolescent; Adult; Analgesics, Non-Narcotic; | 2020 |
The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Australia; Cannabidiol; Double-Blind Method; | 2021 |
Extending the safety profile of the post-operative administration of an intravenous acetaminophen/ibuprofen fixed dose combination: An open-label, multi-center, single arm, multiple dose study.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, | 2021 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2017 |
Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2018 |
Efficacy and safety of fixed-dose combination of drotaverine hydrochloride (80 mg) and paracetamol (500 mg) in amelioration of abdominal pain in acute infectious gastroenteritis: A randomized controlled trial.
Topics: Abdominal Pain; Acetaminophen; Acute Pain; Administration, Oral; Adolescent; Adult; Analgesics; Doub | 2018 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial.
Topics: Abdominal Muscles; Acetaminophen; Acute Pain; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics | 2019 |
Randomized Clinical Trial of Intravenous Acetaminophen as an Analgesic Adjunct for Older Adults With Acute Severe Pain.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Aged; Analgesics, Non-Narcotic; Analgesics, | 2019 |
Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Analgesics, | 2019 |
Optimising pain management in children with acute otitis media through a primary care-based multifaceted educational intervention: study protocol for a cluster randomised controlled trial.
Topics: Acetaminophen; Acute Pain; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Cost-Bene | 2018 |
Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics; Double-Blind Method; Drug Combinations; Fe | 2018 |
Effect on Morphine Requirement of Early Administration of Oral Acetaminophen vs. Acetaminophen/Tramadol Combination in Acute Pain.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Age | 2019 |
Acetaminophen reduces acute and persistent incisional pain after hysterectomy.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Female; Humans; Hysterectomy; Pai | 2018 |
Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Antiemetics; Drug Combinations; Fe | 2019 |
Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation.
Topics: Acetaminophen; Acute Pain; Administration, Intranasal; Administration, Oral; Adult; Dental Pulp Necr | 2019 |
Metamizole vs. ibuprofen at home after day case surgery: A double-blind randomised controlled noninferiority trial.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesics, | 2019 |
PACE--the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan.
Topics: Acetaminophen; Acute Pain; Analgesics; Data Interpretation, Statistical; Disability Evaluation; Doub | 2013 |
Effect of high-dose paracetamol on needle procedures in children with cancer--an RCT.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Anesthesia; Child; Child, Preschool | 2014 |
A randomized, double-blind, placebo-controlled study of the efficacy and safety of MNK-795, a dual-layer, biphasic, immediate-release and extended-release combination analgesic for acute pain.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Delayed-Action Preparations; Double-Blind Method; Drug | 2014 |
Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Codeine; Double-Blind Method; Drug | 2014 |
Validating speed of onset as a key component of good analgesic response in acute pain.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; | 2015 |
Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Drug Administration | 2014 |
Intermittent epidural vs continuous wound infusion of ropivacaine for acute and chronic pain control after hysterectomy or myomectomy: a randomized controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Amides; Analgesia, Epidural; Analgesics; Anesthetics, Local; Chron | 2014 |
Assessment of the safety and efficacy of extended-release oxycodone/acetaminophen, for 14 days postsurgery.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Delayed-Action Preparations; | 2014 |
A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Arthroplasty, Replace | 2015 |
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2014 |
Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Delayed-Action Prepa | 2015 |
Preoperative dexamethasone reduces acute but not sustained pain after lumbar disk surgery: a randomized, blinded, placebo-controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammato | 2015 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
Emergency Department Patient Perspectives on the Risk of Addiction to Prescription Opioids.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Opioid; Back Pain; Behavior, Addictive; Drug Com | 2016 |
Comparative Analgesic Efficacy of Oxycodone/Acetaminophen Versus Hydrocodone/Acetaminophen for Short-term Pain Management in Adults Following ED Discharge.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Serv | 2015 |
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal | 2016 |
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal | 2016 |
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal | 2016 |
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal | 2016 |
Comparison of the effects of treatment with celecoxib, loxoprofen, and acetaminophen on postoperative acute pain after arthroscopic knee surgery: A randomized, parallel-group trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Anterior Cruciate Ligament Injuries; Ant | 2016 |
The economic burden of guideline-recommended first line care for acute low back pain.
Topics: Acetaminophen; Acute Pain; Adult; Australia; Cost of Illness; Costs and Cost Analysis; Female; Healt | 2018 |
Randomised comparison of intravenous paracetamol and intravenous morphine for acute traumatic limb pain in the emergency department.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Do | 2012 |
Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Chronic Pain; Codeine; Double-Blind Method; Drug Combi | 2012 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Tramadol or paracetamol do not effect the diagnostic accuracy of acute abdominal pain with significant pain relief - a prospective, randomized, placebo controlled double blind study.
Topics: Abdominal Pain; Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Chi- | 2012 |
33 other studies available for acetaminophen and Acute Pain
| Article | Year |
|---|---|
Evidence-Based Guidelines for Prehospital Pain Management: Recommendations.
Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2023 |
Compatibility of intravenous acetaminophen with morphine, fentanyl and ketamine in acute pediatric pain setting.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Child; Double-Blind Method; Fentanyl; Humans; Ketamin | 2022 |
Racial differences in treatment among patients with acute headache evaluated in the emergency department and discharged home.
Topics: Acetaminophen; Acute Pain; Analgesics; Emergency Service, Hospital; Headache; Healthcare Disparities | 2022 |
Paracetamol and ibuprofen combination for the management of acute mild-to-moderate pain in children: expert consensus using the Nominal Group Technique (NGT).
Topics: Acetaminophen; Acute Pain; Administration, Oral; Analgesics, Non-Narcotic; Child; Consensus; Drug Co | 2023 |
Evaluation of antinociceptive effect and pharmacological mechanisms of thiocyanoacetamide in rats.
Topics: Acetaminophen; Acute Pain; Adrenergic Agents; Analgesics; Animals; Dexamethasone; Dose-Response Rela | 2023 |
An Open-label, Prospective, Multicentric, Cohort Study of Nimesulide/Paracetamol Fixed Drug Combination for Acute Pain Management: Sub-group Analysis.
Topics: Acetaminophen; Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Drug Combination | 2023 |
Application of analgesics in emergency services in Germany: a survey of the medical directors.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Butylsco | 2023 |
Intravenous acetaminophen does not have an opioid sparing effect in Emergency Department patients with painful conditions.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Analgesics, | 2021 |
Response to Mazer-Amirshahi et al, Intravenous Acetaminophen and Hydromorphone: The Bad and the Ugly of Emergency Department Pain Management.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Emergency Service, Hospital; Humans; Hydromo | 2020 |
Intravenous Acetaminophen and Hydromorphone: The Bad and the Ugly of Emergency Department Pain Management.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Emergency Service, Hospital; Humans; Hydromo | 2020 |
In non-low back musculoskeletal injuries, NSAIDs and acetaminophen reduce acute pain.
Topics: Acetaminophen; Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Meta-Analysis; R | 2020 |
Analgesic efficacy of morphine sulfate immediate release vs. oxycodone/acetaminophen for acute pain in the emergency department.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Serv | 2021 |
Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2021 |
A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Chronic Pain; Cod | 2021 |
Acute pain management: acetaminophen and ibuprofen are often under-dosed.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Administration, Oral; Administration, Rectal | 2017 |
Opioids for Acute Pain: Proceed with Caution.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Chronic Pain; Drug Combinations; Female; Fract | 2018 |
Safety in Acute Pain Medicine-Pharmacologic Considerations and the Impact of Systems-Based Gaps.
Topics: Acetaminophen; Acute Pain; Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; K | 2018 |
The glycation products before and after therapy for acute and chronic pain.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Biomarkers; Chronic Pain; Female; Glycation En | 2018 |
Clinical Pharmacology Considerations in Pain Management in Patients with Advanced Kidney Failure.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Chronic Pain | 2019 |
Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review.
Topics: Acetaminophen; Acute Pain; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio | 2013 |
FDA approves oxycodone and acetaminophen extended-release tablets.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Delayed-Action Preparations; Drug Approval; Drug Comb | 2014 |
Extended-release oxycodone and acetaminophen (Xartemis XR).
Topics: Acetaminophen; Acute Pain; Delayed-Action Preparations; Humans; Oxycodone | 2014 |
Do patients with acute low-back pain need paracetamol?
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male | 2014 |
[Not Available].
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male | 2014 |
Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Analgesics; Animals; Behavior, Animal; Carbazoles; Disease Models, Animal | 2015 |
Up to 4000 mg of paracetamol a day is ineffective for acute low back pain.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male | 2015 |
The Potential Role of an Extended-Release, Abuse-Deterrent Oxycodone/Acetaminophen Fixed-Dose Combination Product for the Treatment of Acute Pain.
Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemistry, Phar | 2015 |
Acute calcific periarthiritis of the knee presenting with calcification within the lateral collateral ligament.
Topics: Acetaminophen; Acute Pain; Aged; Analgesia; Calcinosis; Codeine; Collateral Ligaments; Drug Combinat | 2015 |
Evaluation of the tamper-resistant properties of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets.
Topics: Acetaminophen; Acute Pain; Administration, Intranasal; Analgesics, Opioid; Chronic Pain; Delayed-Act | 2016 |
Single dose oral analgesics for postoperative pain have few adverse events.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Analgesics; Humans; Pain, Postoperative | 2016 |
Reducing postoperative pain by changing the process.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-N | 2011 |
OFIRMEV: a recently introduced drug.
Topics: Acetaminophen; Acute Pain; Analgesics; Antipyretics; Clinical Trials as Topic; Drug Approval; Fever; | 2011 |
Analgesic use in a national community sample of German children and adolescents.
Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics; Aspirin; Child; Child, Preschool; Chronic Pain; F | 2012 |