acetaminophen has been researched along with Acute Liver Injury, Drug-Induced in 3012 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal." | 8.86 | Mechanisms of acetaminophen-induced liver necrosis. ( Hinson, JA; James, LP; Roberts, DW, 2010) |
| " This paper reviews the reported data related to the effects of diabetes and hypertriglyceridemia, common lifestyle-related diseases in a modern society, on acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats and mice." | 8.85 | Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice. ( Doi, K; Ishida, K, 2009) |
| "Acetaminophen (APAP) is the most common drug overdose in pregnancy." | 8.82 | Acetaminophen overdose in pregnancy. ( Clark, LE; Herrera, JL; Wilkes, JM, 2005) |
| "The optimal route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial." | 8.80 | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? ( Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM, 1999) |
| "Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child." | 8.76 | Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ( Collins, E, 1981) |
| "Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 8.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
| "The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD)." | 8.31 | Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway. ( Fu, D; Hu, C; Huang, Y; Jiang, X; Li, Y; Wen, J; Wu, S; Xin, J; You, T, 2023) |
| "Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display both hyper- and hypocoagulable changes not necessarily recapitulated by standard hepatotoxic doses of APAP used in mice (eg, 300 mg/kg)." | 8.31 | Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. ( Bouck, EG; Groeneveld, DJ; Lisman, T; Luyendyk, JP; Poole, LG; Schulte, A; Watson, VE; Wei, Z; Williams, KJ; Wolberg, AS, 2023) |
| "Acetaminophen (Act) overdose is a known inducer of liver failure in both children and adults." | 8.31 | Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. ( Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A, 2023) |
| " Chronic alcoholic fatty liver disease (AFLD) appears to enhance the risk and severity of APAP-induced liver injury, and the level of angiotensin II (Ang II) increased sharply at the same time." | 8.12 | Caveolin-1 Alleviates Acetaminophen-Induced Hepatotoxicity in Alcoholic Fatty Liver Disease by Regulating the Ang II/EGFR/ERK Axis. ( Feng, X; Fu, D; Hu, C; Huang, Y; Jiang, W; Jiang, X; Wang, J; Wen, J; Xin, J; You, T, 2022) |
| "Of the 345 patients included in the study, elevated AST/ALT levels were attributed to rhabdomyolysis in 168 patients and attributed to acetaminophen toxicity in 177 patients." | 8.02 | Patterns of transaminase elevation in rhabdomyolysis versus acetaminophen toxicity. ( Maskell, KF; Okhomina, V; Powell, SW; Sima, AP; Willis, D; Wills, BK, 2021) |
| "Acetaminophen (APAP)-induced acute liver failure (ALF) remains the most common cause of ALF in the Western world." | 8.02 | A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure. ( Agarwal, K; Aluvihare, VR; Heneghan, MA; Karvellas, CJ; Lee, WM; McPhail, MJW; Menon, K; Prachalias, A; Rose, CF; Salehi, S; Speiser, JL; Tavabie, OD, 2021) |
| "The metabolic fate, toxicity, and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF)." | 7.96 | Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. ( Coen, M; Dare, TO; Dargue, R; Jalan, R; Lau, C; Lee, K; Nicholls, AW; Wilson, ID; Zia, R, 2020) |
| "Acetaminophen (APAP) overdose is one of the major etiologies of liver failure." | 7.96 | Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure. ( Chang, LY; Hsu, CY; Huang, CH; Huang, CT; Huang, SK; Lin, CY; Lin, YC; Yang, CK, 2020) |
| "Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated." | 7.91 | Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. ( Dai, G; Feng, Q; Liang, C; Liu, L; Luo, L; Sun, J; Xia, W; Yang, J; Zhao, N, 2019) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 7.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| "The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene." | 7.85 | The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. ( Aktas, MS; Dokumacioglu, A; Dokumacioglu, E; Hanedan, B; Iskender, H; Musmul, A; Sen, TM, 2017) |
| "During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain." | 7.81 | Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. ( Arck, P; Barikbin, R; Erhardt, A; Huebener, P; Karimi, K; Keßler, T; Ramisch, K; Thiele, K; Tiegs, G, 2015) |
| "Chronic hepatitis C virus (HCV) infection predisposes patients to develop liver failure after acetaminophen (APAP) overdose." | 7.81 | Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice. ( Jaeschke, H; Lebofsky, M; Ramachandran, A; Weinman, SA; Yan, HM, 2015) |
| " perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated." | 7.81 | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. ( Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA, 2015) |
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 7.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| "We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen." | 7.80 | The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. ( Cogger, VC; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, BE; Le Couteur, DG; Mach, J; McKenzie, C, 2014) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 7.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 7.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
| "We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period." | 7.77 | Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011) |
| "We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity." | 7.74 | Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008) |
| "An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication." | 7.73 | Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006) |
| "The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure." | 7.71 | Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report. ( Contos, MJ; Gill, EJ; Peng, TC, 2002) |
| " Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days." | 7.71 | [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. ( Janssens, AR; van Mil, AH, 2001) |
| "Metabolic acidosis and coma may develop in patients who experience severe hepatic injury after acetaminophen poisoning." | 7.70 | Early metabolic acidosis and coma after acetaminophen ingestion. ( Blanc, P; Roth, B; Woo, O, 1999) |
| "It is often taught that acetaminophen-induced liver dysfunction occurs only after a latent period of 24 to 48 hours." | 7.69 | The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. ( Carracio, TR; Mofenson, HC; Singer, AJ, 1995) |
| "The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)." | 7.69 | Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996) |
| "We report two cases of severe acetaminophen poisoning with favorable outcome after delayed medical treatment with N-acetylcysteine, despite severe hepatic disturbances." | 7.68 | Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases. ( Deckers, O; Hantson, P; Mahieu, P; Van Vyve, T, 1993) |
| " After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)." | 7.67 | Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 7.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities." | 7.66 | Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 7.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Two family members developed severe hepatitic dysfunction in association with infectious mononucleosis and acetaminophen administration." | 7.65 | Acetaminophen and hepatic dysfunction in infectious mononucleosis. ( Manning, IH; Meyer, AA; Neelon, FA; Rosenberg, DM, 1977) |
| "Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose." | 6.66 | Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020) |
| " Moreover, there is evidence that the maximum recommended dosage can induce hepatic cytolysis in some individuals." | 6.50 | Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease. ( Fromenty, B; Michaut, A; Moreau, C; Robin, MA, 2014) |
| "Inflammation is a critical component of the overall pathophysiology, not only as a potential factor that may aggravate cell damage, but more importantly as a vital response to limit cell injury, remove cell debris and promote regeneration." | 6.43 | Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. ( Jaeschke, H, 2005) |
| " The literature shows that excessive or long-term use of APAP can lead to increased cardiovascular dysfunction." | 5.91 | Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease. ( Feng, X; Fu, D; Hu, C; Huang, Y; Jiang, X; Li, Y; Wen, J; Wu, S; Xin, J; You, T, 2023) |
| "Abietic acid has been known to exhibit anti-inflammatory activity." | 5.91 | Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. ( An, Y; Guan, L; Han, D; Luo, Q, 2023) |
| "Acetaminophen (APAP) may cause acute liver injury with therapeutic doses in high-risk conditions such as chronic alcohol consumption or malnutrition." | 5.91 | Association between adverse outcomes of hepatitis A and acetaminophen use: A population-based cohort study. ( Chung, JW; Jang, ES; Kim, JW; Park, GC, 2023) |
| "Acetaminophen (APAP) is a common antipyretic and analgesic drug that can cause long-term liver damage after an overdose." | 5.91 | Caveolin-1 protects against liver damage exacerbated by acetaminophen in non-alcoholic fatty liver disease by inhibiting the ERK/HIF-1α pathway. ( Fu, D; Hu, C; Huang, Y; Jiang, X; Jin, L; Li, B; Li, Y; Wu, S; Xin, J; You, T, 2023) |
| "Acetaminophen (APAP) can cause acute liver failure, but treatment options are still limited." | 5.72 | Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation. ( Kim, GM; Kim, JY; Leem, J, 2022) |
| "Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models." | 5.72 | Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin. ( Abdel Kader, DH; Al-Ani, B; Dallak, M; Dawood, AF; Eid, RA; Haidara, MA; Kamar, SS; Shams Eldeen, AM, 2022) |
| "Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases." | 5.62 | CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021) |
| "Liver failure is a serious hepatic dysfunction with high mortality." | 5.62 | Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats. ( Chen, L; Chen, X; Jiang, H; Li, L; Lv, L; Wang, K; Wang, Q; Yan, R, 2021) |
| "Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI." | 5.62 | Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. ( Ezhilarasan, D; Raghunandhakumar, S, 2021) |
| " HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined." | 5.56 | New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. ( Devière, J; Dressen, C; Gustot, T; Leclercq, I; Lemmers, A; Liefferinckx, C; Minsart, C; Moreau, R; Quertinmont, E, 2020) |
| "Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies." | 5.56 | Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020) |
| " One of the biggest problems of these compounds, however, is their very short bioavailability due to instant metabolism and rapid excretion." | 5.51 | Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury. ( Ibayashi, Y; Lee, Y; Nagasaki, Y; Ngo, DN; Nishikawa, Y; Vong, LB, 2019) |
| "Acetaminophen is a widely available analgesic and antipyretic medication." | 5.51 | [Acetaminophen poisonings hospitalized at the Pomeranian Center of Toxicology in 2010-2015]. ( Garczewski, B; Sein Anand, J; Waldman, W; Wiśniewski, M, 2019) |
| "Shikonin is a natural product with antioxidant and anti-inflammatory activities." | 5.51 | Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. ( Chen, F; Guo, H; Hu, Y; Hua, H; Jia, Z; Jing, X; Li, D; Sun, J; Xu, J; Yu, X, 2019) |
| "Patients with cystic fibrosis are more likely to have glutathione deficiency, and greater susceptibility to liver injury." | 5.48 | Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity. ( Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A, 2018) |
| "Acetaminophen (APAP) is a readily available and safe painkiller." | 5.46 | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. ( Choi, D; Kim, JY; Kim, TH; Koo, SH; Lee, JH, 2017) |
| "Obesity and nonalcoholic fatty liver disease (NAFLD) can increase susceptibility to hepatotoxicity induced by some xenobiotics including drugs, but the involved mechanisms are poorly understood." | 5.43 | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. ( Bucher, S; Fromenty, B; Gicquel, T; Jaeschke, H; Le Guillou, D; Martinais, S; McGill, MR; Michaut, A; Moreau, C; Morel, I; Robin, MA, 2016) |
| "A total of 125,505 patients with liver cirrhosis were registered from January 1, 2012 to December 31, 2012." | 5.43 | The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis. ( An, DS; Cho, M; Han, JH; Heo, J; Hong, YM; Lim, W; Woo, HY; Yoon, KT, 2016) |
| "Chlorogenic acid (CGA) has been reported to prevent acetaminophen (AP)-induced hepatotoxicity when mice were pre-administered orally with CGA for consecutive 7days before AP intoxication in our previous study." | 5.42 | The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation. ( Ji, L; Lu, B; Sheng, Y; Zheng, Z, 2015) |
| " While the hepatotoxic effects of the drug have been well recognized in cases of acute overdose and chronic supratherapeutic doses, the toxic effects of acetaminophen are rarely documented in cases where therapeutic guidelines are followed." | 5.39 | Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity. ( Boyajian, M; Cheerharan, M; Iorio, ML; Kaufman, SS; Reece-Stremtan, S, 2013) |
| "Vomiting was present in 65." | 5.36 | Assessing the impact of vomiting episodes on outcome after acetaminophen poisoning. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010) |
| "Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing." | 5.33 | Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. ( Hennig, GE; Manautou, JE; Silva, VM, 2006) |
| "Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 5.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
| " The development of type B lactic acidosis with hypoglycemia might have been caused by a deficit in gluconeogenesis secondary to severe hepatic failure and/or a toxic metabolite of acetaminophen." | 5.27 | Anion gap acidosis with hypoglycemia in acetaminophen toxicity. ( Schnurr, LP; Zabrodski, RM, 1984) |
| " A comparison of the dose-response curves for hepatic glycogen depletion and glutathione depletion showed that acetaminophen (50-500 mg/kg at 2." | 5.27 | Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice. ( Cameron, AM; Hinson, JA; Mays, JB, 1983) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 5.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| " There are many underlying etiologies, including acetaminophen toxicity, drug induced liver injury, and hepatitis." | 5.01 | Acute liver failure: A review for emergency physicians. ( Koyfman, A; Long, B; Montrief, T, 2019) |
| " Despite abundant experimental data showing that fatty liver is more susceptible to liver injury, drug-induced liver disease seems no more frequent in NAFLD patients, except, possibly, a higher incidence but not severity of acetaminophen hepatotoxicity." | 4.90 | The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease. ( Pais, R; Ratziu, V; Rusu, E, 2014) |
| " This review summarises the evidence for potential therapeutic applications of non-immunosuppressive cyclophilin inhibitors, alone or in combination with other agents, in virus-induced liver diseases like hepatitis C, B or Delta, liver inflammation and fibrosis, acetaminophen-induced liver toxicity and hepatocellular carcinoma." | 4.90 | Cyclophilin inhibition as potential therapy for liver diseases. ( Naoumov, NV, 2014) |
| "Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal." | 4.86 | Mechanisms of acetaminophen-induced liver necrosis. ( Hinson, JA; James, LP; Roberts, DW, 2010) |
| " This paper reviews the reported data related to the effects of diabetes and hypertriglyceridemia, common lifestyle-related diseases in a modern society, on acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats and mice." | 4.85 | Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice. ( Doi, K; Ishida, K, 2009) |
| "Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100-200 deaths per year." | 4.84 | Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature. ( Dargan, PI; Edwards, JN; Hawkins, LC, 2007) |
| "To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen." | 4.84 | COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008) |
| "Acetaminophen (APAP) is the most common drug overdose in pregnancy." | 4.82 | Acetaminophen overdose in pregnancy. ( Clark, LE; Herrera, JL; Wilkes, JM, 2005) |
| "The optimal route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial." | 4.80 | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? ( Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM, 1999) |
| "Acetaminophen poisoning is a significant medical problem in the United States and is frequently managed by family physicians." | 4.79 | Management of acetaminophen toxicity. ( Fuller, SH; Larsen, LC, 1996) |
| "Based on recent reports concerning the efficacy of N-acetylcysteine (NAC) in paracetamol (acetaminophen) poisoning, guidelines for treatment and control of these patients are reviewed by a study group under the Danish Association for the Study of the Liver." | 4.79 | [Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver]. ( Astrup, LB; Clemmesen, JO; Dalhoff, KP; Ott, P; Poulsen, HE; Tage-Jensen, U, 1996) |
| "Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child." | 4.76 | Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ( Collins, E, 1981) |
| "Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 4.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
| "The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD)." | 4.31 | Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway. ( Fu, D; Hu, C; Huang, Y; Jiang, X; Li, Y; Wen, J; Wu, S; Xin, J; You, T, 2023) |
| " Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with subsequent inflammation, inflicting further liver damage." | 4.31 | Hepatic C-X-C chemokine receptor type 6-expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury. ( Araujo David, B; Batista Carneiro, M; Heymann, F; Kohlhepp, MS; Krenkel, O; Kubes, P; Liepelt, A; Mossanen, JC; Niemietz, PM; Peiseler, M; Tacke, F, 2023) |
| "Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display both hyper- and hypocoagulable changes not necessarily recapitulated by standard hepatotoxic doses of APAP used in mice (eg, 300 mg/kg)." | 4.31 | Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. ( Bouck, EG; Groeneveld, DJ; Lisman, T; Luyendyk, JP; Poole, LG; Schulte, A; Watson, VE; Wei, Z; Williams, KJ; Wolberg, AS, 2023) |
| "Acetaminophen (Act) overdose is a known inducer of liver failure in both children and adults." | 4.31 | Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. ( Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A, 2023) |
| "Excessive acetaminophen (APAP) intake causes oxidative stress and inflammation, leading to fatal hepatotoxicity; however, the mechanism remains unclear." | 4.12 | Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity. ( Chen, Y; Cui, T; Duan, S; Gao, Y; Guo, J; Lin, S; Liu, C; Pan, Z; Tang, K; Wu, Z; Xiao, X; Yang, Z; Zhong, C; Zhong, G; Zhong, Y, 2022) |
| " Chronic alcoholic fatty liver disease (AFLD) appears to enhance the risk and severity of APAP-induced liver injury, and the level of angiotensin II (Ang II) increased sharply at the same time." | 4.12 | Caveolin-1 Alleviates Acetaminophen-Induced Hepatotoxicity in Alcoholic Fatty Liver Disease by Regulating the Ang II/EGFR/ERK Axis. ( Feng, X; Fu, D; Hu, C; Huang, Y; Jiang, W; Jiang, X; Wang, J; Wen, J; Xin, J; You, T, 2022) |
| " Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively." | 4.12 | Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models. ( Ahsan, H; Anjum, I; Ismail, S; Kahrizi, D; Movafagh, A; Naveed Mushtaq, M; Ramzan, HM; Razzaq, A; Shabbir, U; Shoukat, A, 2022) |
| "The aim of the research was to investigate the hepatoprotective properties of the Maitake mushrooms thick extract in the experiment on rats with paracetamol (acetaminophen)-induced hepatitis." | 4.02 | Application of the thick extract from Maitake mushrooms for correction of metabolic disorders under the paracetamol hepatitis in rats. ( Fira, L; Herasymets, I; Medvid, I, 2021) |
| "Of the 345 patients included in the study, elevated AST/ALT levels were attributed to rhabdomyolysis in 168 patients and attributed to acetaminophen toxicity in 177 patients." | 4.02 | Patterns of transaminase elevation in rhabdomyolysis versus acetaminophen toxicity. ( Maskell, KF; Okhomina, V; Powell, SW; Sima, AP; Willis, D; Wills, BK, 2021) |
| "Acetaminophen (APAP)-induced acute liver failure (ALF) remains the most common cause of ALF in the Western world." | 4.02 | A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure. ( Agarwal, K; Aluvihare, VR; Heneghan, MA; Karvellas, CJ; Lee, WM; McPhail, MJW; Menon, K; Prachalias, A; Rose, CF; Salehi, S; Speiser, JL; Tavabie, OD, 2021) |
| "The metabolic fate, toxicity, and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF)." | 3.96 | Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. ( Coen, M; Dare, TO; Dargue, R; Jalan, R; Lau, C; Lee, K; Nicholls, AW; Wilson, ID; Zia, R, 2020) |
| " Finally, PiTMaP was applied to two cases: (1) an acetaminophen-induced acute liver injury model and control mice and (2) human meningioma samples with different grades (G1-G3), demonstrating the feasibility of PiTMaP." | 3.96 | PiTMaP: A New Analytical Platform for High-Throughput Direct Metabolome Analysis by Probe Electrospray Ionization/Tandem Mass Spectrometry Using an R Software-Based Data Pipeline. ( Eguchi, S; Iguchi, A; Ishii, A; Kawamata, T; Kondo, K; Ohara, T; Tsuchihashi, H; Zaitsu, K, 2020) |
| "Acetaminophen (APAP) overdose is one of the major etiologies of liver failure." | 3.96 | Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure. ( Chang, LY; Hsu, CY; Huang, CH; Huang, CT; Huang, SK; Lin, CY; Lin, YC; Yang, CK, 2020) |
| "Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes." | 3.91 | Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. ( Bae, SH; Cho, Y; Jo, Y; Kim, HS; Kim, JH; Lee, B; Lee, DH; Lee, YH; Lee, YS; Nam, KT; Park, JS, 2019) |
| "Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated." | 3.91 | Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. ( Dai, G; Feng, Q; Liang, C; Liu, L; Luo, L; Sun, J; Xia, W; Yang, J; Zhao, N, 2019) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 3.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| " N-acetyl-p-aminophenol (APAP), commonly known as acetaminophen, generates excessive oxidative stress and triggers hepatocyte cell death, exemplified by regulated necrosis." | 3.88 | Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression. ( Jeon, BS; Lee, BW; Yoon, BI, 2018) |
| "Coconut water vinegar has helped to attenuate acetaminophen-induced liver damage by restoring antioxidant activity and suppression of inflammation." | 3.88 | Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice. ( Alitheen, NB; Beh, BK; Ho, WY; Ky, H; Lim, KL; Long, K; Mohamad, NE; Sharifuddin, SA; Yeap, SK, 2018) |
| "The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene." | 3.85 | The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. ( Aktas, MS; Dokumacioglu, A; Dokumacioglu, E; Hanedan, B; Iskender, H; Musmul, A; Sen, TM, 2017) |
| " In total, 1196 samples from 241 individuals across four independent cohorts were profiled: healthy volunteers receiving acetaminophen, patients with human immunodeficiency virus and/or tuberculosis receiving treatment, DILI cases originating from a wide spectrum of drugs, and healthy volunteers receiving heparins." | 3.85 | Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury. ( Aderaye, G; Aklillu, E; Andrade, RJ; Arber, N; Bachmann, J; Drobin, K; Fier, I; Göpfert, J; Gry, M; Kampf, C; Lindberg, J; Lucena, MI; Makonnen, E; Mikus, M; Nilsson, P; Perazzo, H; Poynard, T; Roach, J; Schuppe-Koistinen, I; Schwenk, JM; Stephens, C; Uhlén, M; Watkins, PB; Yimer, G, 2017) |
| "Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis." | 3.85 | Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. ( Aoyama, T; Arai, K; Ikejima, K; Kon, K; Kusama, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
| " Liver histology showed more intense centrilobular necrosis in splenectomized group in comparison to the others, suggesting a protective role of spleen in acetaminophen-induced liver injury." | 3.85 | Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice. ( Almeida, CS; de Oliveira, EE; de Paoli, F; Figueiredo, BBM; Grunewald, STF; Mendonça, ACP; Rezende, AB; Teixeira, HC, 2017) |
| "Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain." | 3.85 | Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017) |
| " This permitted studies of whether transplanted KC could affect outcomes in the context of acetaminophen hepatotoxicity or hepatic ischemia-reperfusion injury." | 3.83 | Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy. ( Bhargava, KK; Follenzi, A; Gupta, S; Merlin, S; Palestro, CJ; Prat, M; Ranaldo, G; Santambrogio, L; Zanolini, D, 2016) |
| " The extract of the plant leaves shows hepatoprotective effects in rats intoxicated by administration of acetaminophen and exhibits hypolipidemic activity in rats with high-fat-diet induced hypercholesterolemia." | 3.83 | Beta vulgaris subspecies cicla var. flavescens (Swiss chard): flavonoids, hepatoprotective and hypolipidemic activities. ( Hamed, MA; Hashem, AN; Lindequist, U; Nawwar, MA; Soliman, MS; Swilam, NF, 2016) |
| "DILI is an uncommon indication for hospitalization carrying lower risks of death except in patients with non-acetaminophen, cirrhosis, elderly or concomitant diseases." | 3.83 | The incidence, presentation, outcomes, risk of mortality and economic data of drug-induced liver injury from a national database in Thailand: a population-base study. ( Pan-Ngum, W; Phaosawasdi, K; Poovorawan, K; Sobhonslidsuk, A; Soonthornworasiri, N, 2016) |
| "During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain." | 3.81 | Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. ( Arck, P; Barikbin, R; Erhardt, A; Huebener, P; Karimi, K; Keßler, T; Ramisch, K; Thiele, K; Tiegs, G, 2015) |
| "WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity." | 3.81 | Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series. ( Davern, TJ; DeMartini, S; Holt, EW, 2015) |
| "Chronic hepatitis C virus (HCV) infection predisposes patients to develop liver failure after acetaminophen (APAP) overdose." | 3.81 | Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice. ( Jaeschke, H; Lebofsky, M; Ramachandran, A; Weinman, SA; Yan, HM, 2015) |
| " perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated." | 3.81 | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. ( Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA, 2015) |
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 3.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| "Acetaminophen-induced fulminant hepatic failure is associated with acute kidney injury, metabolic acidosis, and fluid and electrolyte imbalances, requiring treatment with renal replacement therapies." | 3.81 | The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies. ( Hernandez, SH; Hoffman, RS; Howland, M; Schiano, TD, 2015) |
| "We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen." | 3.80 | The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. ( Cogger, VC; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, BE; Le Couteur, DG; Mach, J; McKenzie, C, 2014) |
| " After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection." | 3.79 | TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013) |
| "Admission M30 levels were significantly elevated in acetaminophen-induced acute liver failure and non-acetaminophen induced acute liver failure patients compared with multiple organ failure, chronic liver disease, and healthy controls." | 3.79 | Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*. ( Abeles, RD; Antoniades, CG; Bernal, W; Dharwan, A; Heaton, ND; Hughes, RD; Jassem, W; Karvellas, CJ; Leslie, EM; Ma, Y; McPhail, MJ; Mitry, RR; Possamai, LA; Puthucheary, Z; Quaglia, A; Rawal, J; Shawcross, DL; Thursz, M; Tidswell, R; Wendon, JA; Zingarelli, V, 2013) |
| "Macrophage activation is implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS) following paracetamol (acetaminophen) overdose (POD)." | 3.79 | Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury. ( Craig, DG; Hayes, PC; Lee, P; Pryde, EA; Simpson, KJ, 2013) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 3.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| " For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure." | 3.79 | Acetaminophen-induced acute liver injury in HCV transgenic mice. ( Boorman, GA; Bradford, BU; Chatterjee, S; Jeannot, E; Kosyk, O; Macdonald, JM; Mason, RP; Melnyk, SB; Pogribny, IP; Rusyn, I; Tech, K; Tryndyak, VP; Uehara, T, 2013) |
| "The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 3.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
| "Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo." | 3.78 | RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. ( Antoine, DJ; Craig, DG; Dear, JW; Jaeschke, H; Jenkins, RE; McGill, MR; Park, BK; Sharpe, MR; Simpson, KJ; Williams, DP, 2012) |
| " Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities." | 3.78 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. ( Akgul, EO; Cakir, E; Cayci, T; Demirbag, S; Eyi, YE; Gul, H; Kaldirim, U; Korkmaz, A; Macit, E; Oter, S; Ozler, M; Oztas, E; Topal, T; Toygar, M; Uysal, B; Yaman, H; Yildirim, AO, 2012) |
| "Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease." | 3.78 | Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. ( Aubert, J; Begriche, K; Delannoy, M; Fromenty, B; Jaeschke, H; Lepage, S; Lucas-Clerc, C; McGill, MR; Morel, I; Pajaud, J; Ribault, C; Robin, MA; Turlin, B, 2012) |
| "We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period." | 3.77 | Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011) |
| " As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue." | 3.75 | Protective Effects of the Supernatant of Ethanol Eluate from Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice [corrected]. ( Jin, GZ; Piao, GC; Yuan, HD, 2009) |
| "We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity." | 3.74 | Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008) |
| "To determine if subjects with chronic alcoholism are predisposed to acetaminophen-induced hepatotoxicity, and to determine the contributing factors." | 3.74 | Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects. ( Anderson, DC; Seifert, CF, 2007) |
| " Adult Sprague-Dawley rats treated with acetaminophen or D-galactosamine (GalN) showed dose- and time-dependent histomorphological changes and TUNEL staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h." | 3.74 | Cytochrome c: a non-invasive biomarker of drug-induced liver injury. ( Adeyemo, O; Hanig, JP; Knapton, A; Miller, TJ; Noory, L; Weaver, J, 2008) |
| "Acetaminophen is an effective mild analgesic and antipyretic agent." | 3.74 | Acetaminophen. ( Ameer, B; Greenblatt, DJ, 1977) |
| "The acetaminophen (APAP)-induced hepatic centrilobular necrosis is preceded by hepatic microcirculatory dysfunction including the infiltration of erythrocytes into the space of Disse." | 3.73 | Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice. ( Abril, ER; Bethea, NW; Ito, Y; McCuskey, RS, 2005) |
| "An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication." | 3.73 | Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006) |
| "The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure." | 3.71 | Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report. ( Contos, MJ; Gill, EJ; Peng, TC, 2002) |
| "Hypophosphatemia is frequently observed in acetaminophen-induced hepatotoxicity and may be involved in the pathogenesis of hepatic failure." | 3.71 | Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity. ( Dalhoff, K; Schmidt, LE, 2002) |
| "To compare the hepatic and renal safety profiles of two daily dosage regimens of paracetamol (acetaminophen) (3 g versus 4 g) in patients with painful chronic rheumatoid diseases." | 3.71 | [Liver and renal tolerance to paracetamol: 3 g or 4 g per day?]. ( Ganry, H; Pruvot, F; Schmidely, N; Vesque, D, 2001) |
| " Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days." | 3.71 | [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. ( Janssens, AR; van Mil, AH, 2001) |
| "High levels of tumor necrosis factor-alpha are associated with an increased risk of severe encephalopathy in acute liver failure, and experimental studies suggest that tumor necrosis factor-alpha plays a role in the development of acetaminophen (paracetamol)-induced liver injury and associated multiple organ failure." | 3.70 | Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. ( Bernal, W; Donaldson, P; Underhill, J; Wendon, J; Williams, R, 1998) |
| "Metabolic acidosis and coma may develop in patients who experience severe hepatic injury after acetaminophen poisoning." | 3.70 | Early metabolic acidosis and coma after acetaminophen ingestion. ( Blanc, P; Roth, B; Woo, O, 1999) |
| "The hepatic centrilobular necrosis produced by the analgesic/antipyretic acetaminophen correlates with metabolic activation of the drug leading to its covalent binding to protein." | 3.70 | Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice. ( Ault, SG; Hinson, JA; Michael, SL; Pumford, NR, 2000) |
| "In this retrospective study we evaluated the frequency of complications in 108 patients with acetaminophen poisoning admitted to the Department of Hepatology, Rigshospitalet, Copenhagen from 1." | 3.69 | [Paracetamol poisoning at a department of hepatology]. ( Clemmesen, JO; Hansen, BA; Larsen, FS; Ott, P, 1995) |
| "Administration of hepatotoxic doses of acetaminophen (APAP) to mice results in necrosis, not only of liver cells but of renal proximal tubules and bronchiolar and olfactory epithelium." | 3.69 | Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity. ( Cartun, RW; Cohen, SD; Hart, SG; Khairallah, EA; Wyand, DS, 1995) |
| "It is often taught that acetaminophen-induced liver dysfunction occurs only after a latent period of 24 to 48 hours." | 3.69 | The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. ( Carracio, TR; Mofenson, HC; Singer, AJ, 1995) |
| " To study this, we reviewed serum enzyme patterns early in the course of acute liver injury in patients with acute viral hepatitis A and B (n = 51), ischemic hepatitis (n = 20), and acetaminophen injury (n = 26)." | 3.69 | Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury. ( Cassidy, WM; Reynolds, TB, 1994) |
| "We have analysed Kupffer cell and 'activated' perisinusoidal cell populations in liver biopsies from patients with paracetamol (acetaminophen)-induced hepatic necrosis of varying degrees of severity." | 3.69 | Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. ( Burt, AD; Hines, JE; James, OF; Mathew, J, 1994) |
| "The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)." | 3.69 | Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996) |
| "We report two cases of severe acetaminophen poisoning with favorable outcome after delayed medical treatment with N-acetylcysteine, despite severe hepatic disturbances." | 3.68 | Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases. ( Deckers, O; Hantson, P; Mahieu, P; Van Vyve, T, 1993) |
| "This is the third case reported of maternal acetaminophen overdose during pregnancy." | 3.68 | Can acetaminophen excess result in maternal and fetal toxicity? ( Kurzel, RB, 1990) |
| " After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)." | 3.67 | Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984) |
| " The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity." | 3.67 | Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984) |
| "A 1-year-old child with severe acetaminophen (APAP) poisoning after ingestion of 10 gm APAP demonstrated central nervous system depression, shock, hypothermia, and metabolic acidosis." | 3.67 | Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child. ( Fleischmann, LE; Hook, JB; Kauffman, RE; Lieh-Lai, MW; Miceli, JN; Newton, JF; Sarnaik, AP, 1984) |
| "Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause." | 3.67 | Fulminant hepatitis. An ultrastructural study. ( Fagan, EA; McCaul, TF; Portmann, B; Tovey, G; Williams, R; Zuckerman, AJ, 1986) |
| "We report a case of fulminant hepatic necrosis occurring in the setting of acetaminophen overdose and chronic alcohol use." | 3.67 | Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology. ( Baeg, NJ; Bodenheimer, HC; Burchard, K, 1988) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 3.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Severe intoxication from excessive acetaminophen without suicidal intent occurred in three patients, all alcohol abusers, one with evidence of underlying cirrhosis." | 3.67 | Enhanced toxicity of acetaminophen in alcoholics: report of three cases. ( Gluskin, LE; Leist, MH; Payne, JA, 1985) |
| "In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities." | 3.66 | Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 3.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture." | 3.65 | Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977) |
| "Two family members developed severe hepatitic dysfunction in association with infectious mononucleosis and acetaminophen administration." | 3.65 | Acetaminophen and hepatic dysfunction in infectious mononucleosis. ( Manning, IH; Meyer, AA; Neelon, FA; Rosenberg, DM, 1977) |
| "A prospective study was undertaken to determine the cause of the acute anemia previously observed in pigs manifesting acute liver necrosis after administration of acetaminophen in dosages in excess of the LD100." | 3.65 | Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia. ( Fiskerstrand, C; Miller, DJ; Pichanick, GG; Saunders, SJ, 1977) |
| "Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage." | 3.65 | Abnormal drug metabolism after barbiturate and paracetamol overdose. ( Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH, 1974) |
| "Acetaminophen (APAP) is a well-known anti-allergic, anti-pyretic, non-steroidal anti-inflammatory drug (NSAID), which upon overdose leads to hepatotoxicity, the major adverse event of this over-the-counter drug." | 3.01 | Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations. ( Anchi, P; Bansod, S; Chilvery, S; Godugu, C; Khurana, A; Saifi, MA; Yelne, A, 2023) |
| "Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury." | 3.01 | The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. ( Huang, L; Luo, G; Zhang, Z, 2023) |
| "Acetaminophen-protein adducts are specific biomarkers of toxic acetaminophen (paracetamol) metabolite exposure." | 2.94 | Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). ( Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW, 2020) |
| "Acetaminophen (APAP) has hepatotoxic potential when overdosed." | 2.94 | Hepatic Adaptation to Therapeutic Doses of Acetaminophen: An Exploratory Study in Healthy Individuals. ( Arakawa, N; Aso, M; Kumagai, Y; Maeda, M; Maekawa, K; Ochiai, M; Ohno, Y; Saito, Y; Sakamoto, Y; Song, I; Tanaka, R, 2020) |
| " This regimen was introduced in the 1970s and has remained largely unchanged even though the initial NAC infusion is frequently associated with adverse reactions, in particular nausea, vomiting, and anaphylactoid reactions." | 2.90 | Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi ( Dear, J, 2019) |
| " Primary endpoints: all participants experienced ≥1 adverse event (AE), most commonly gastrointestinal." | 2.90 | Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial). ( Black, P; Dear, JW; Gallagher, B; Grahamslaw, J; Henriksen, D; Lee, RJ; Morrison, EE; O'Brien, R; Oatey, K; Oosthuyzen, W; Weir, CJ, 2019) |
| "Fomepizole has been linked to few adverse effects." | 2.82 | Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. ( Mehrpour, O; Nakhaee, S; Pourbagher-Shahri, AM; Schimmel, J; Shirazi, FM, 2022) |
| " The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion." | 2.82 | Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. ( Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH, 2022) |
| "As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and increasing the risk of over- or underdosing of medications." | 2.82 | Management of Pharmacologic Adverse Effects in Advanced Liver Disease. ( García-Cortés, M; García-García, A, 2022) |
| "Therapeutic experiments are commonly performed on laboratory animals to investigate the possible mechanism(s) of action of toxic agents as well as drugs or substances under consideration." | 2.82 | A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals. ( Abbasnezhad, A; Mohebbati, R; Salami, F, 2022) |
| "Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF)." | 2.82 | Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review. ( Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H, 2022) |
| " Urine was collected daily before and during dosing and 6 days after the final dose." | 2.78 | Pattern recognition analysis for hepatotoxicity induced by acetaminophen using plasma and urinary 1H NMR-based metabolomics in humans. ( Kim, JW; Kim, KB; Kim, S; Lee, HW; Lim, MS; Ryu, SH; Seong, SJ; Yoon, YR, 2013) |
| " However, the concentrations of APAP-CYS during therapeutic dosing, in cases of acetaminophen toxicity from repeated dosing and in cases of hepatic injury from non-acetaminophen hepatotoxins have not been well characterized." | 2.76 | Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. ( Dart, RC; Green, JL; Heard, KJ; James, LP; Judge, BS; Rhyee, S; Zolot, L, 2011) |
| "We enrolled chronic alcohol abusers (defined as >or= 6 drinks daily for >or= 6 weeks) who had discontinued alcohol consumption 12 to 72 hours prior to enrollment." | 2.73 | Are recommended doses of acetaminophen hepatotoxic for recently abstinent alcoholics? A randomized trial. ( Bartels, S; Crosby, D; Richard, J; Sivilotti, M, 2008) |
| " At therapeutic recommended doses, acetaminophen forms limited amounts of N-acetyl-p-benzoquinone-imine (NAPQI) without adverse cellular effects." | 2.72 | Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. ( Atillasoy, E; Bandara, SB; Chappell, GA; Cohen, SM; Deore, M; Eichenbaum, G; Hardisty, JF; Hermanowski-Vosatka, A; Jacobson-Kram, D; Jaeschke, H; Kuffner, E; Monnot, AD; Murray, FJ; Pitchaiyan, SK; Wikoff, D, 2021) |
| " N-Acetylcysteine should be given according to specific regimens through weight-based dosing tables." | 2.72 | Paracetamol overdose in the newborn and infant: a life-threatening event. ( Antonucci, R; Capobianco, G; Cuzzolin, L; Locci, C, 2021) |
| "Acetaminophen (APAP) is a widely used antipyretic and analgesic drug that is safe and effective in the therapeutic doses, but overdose may cause hepatotoxicity and even acute liver failure (ALF)." | 2.72 | [Research progress on hepatotoxicity of acetaminophen]. ( Hu, T; Huang, WQ; Sun, H, 2021) |
| "Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose-depedent toxin." | 2.72 | The complex roles of neutrophils in APAP-induced liver injury. ( Chen, S; Guo, H; Xie, M; Zheng, M; Zhou, C, 2021) |
| "Acetaminophen is a common medication taken in deliberate self-poisoning and unintentional overdose." | 2.72 | Acetaminophen Poisoning. ( Buckley, NA; Chiew, AL, 2021) |
| " Several novel approaches to the management of acetaminophen overdose have been suggested to improve patient safety by reducing adverse drug reactions and dosing errors." | 2.72 | A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose. ( Burnham, K; Knight, S; Smith, H; Yang, T, 2021) |
| "Acetaminophen (paracetamol) was used to induce oxidative damage in cats, and to then determine the effect of SAMe treatment on erythrocyte morphology, PCV, liver histopathology, thiobarbituate reacting substances (TBARS), reduced glutathione (GSH), and oxidised glutathione (GSSG)." | 2.71 | S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury. ( Fettman, MJ; Mason, G; Twedt, DC; Webb, CB, 2003) |
| "Acetaminophen was not administered until the alcohol had been eliminated." | 2.70 | Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial. ( Bogdan, GM; Casper, E; Dart, RC; Darton, L; Hill, RE; Kuffner, EK, 2001) |
| "Liver injury and acute liver failure caused by acetaminophen (APAP, N-acetyl-p-aminophenol, paracetamol) overdose is a significant clinical problem in most western countries." | 2.66 | Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure. ( Akakpo, JY; Jaeschke, H; Ramachandran, A; Umbaugh, DS, 2020) |
| " In this article, we review recent pharmacological and toxicological findings about APAP from basic, clinical, and epidemiological studies, including spontaneous drug adverse events reporting system, especially focusing on drug-induced asthma and pre-and post-natal closure of ductus arteriosus." | 2.66 | Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug? ( Ishitsuka, Y; Kadowaki, D; Kondo, Y, 2020) |
| "Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose." | 2.66 | Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020) |
| "Acetaminophen is a widely used analgesic for pain management, especially useful in chronic diseases, such as rheumatoid arthritis." | 2.66 | Acetaminophen Oxidation and Inflammatory Markers - A Review of Hepatic Molecular Mechanisms and Preclinical Studies. ( Barcelos, RP; de Carvalho, NR; Reis, SB; Soares, FAA; Stefanello, ST, 2020) |
| " It is adequately comprehended that the metabolism of high-dose APAP by cytochrome P450 enzymes generates N-acetyl-p-benzoquinone imine (NAPQI), a toxic metabolite, which leads to glutathione (GSH) depletion, oxidative stress, and activation of various complex molecular pathways that initiate liver injury and downstream hepatic necrosis." | 2.66 | Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. ( Adelusi Temitope, I; Chowdhury, A; Nabila, J; Wang, S, 2020) |
| "Fomepizole (4-methylpyrazole) is safe and has shown efficacy in preclinical models, human hepatocytes and in volunteers against APAP overdose." | 2.66 | Novel strategies for the treatment of acetaminophen hepatotoxicity. ( Akakpo, JY; Jaeschke, H; Ramachandran, A, 2020) |
| "Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market approximately 65 years ago." | 2.66 | The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. ( Hinson, JA; McGill, MR, 2020) |
| " Furthermore, there have been recent concerns over the safety profile of paracetamol, with reports of gastrointestinal, cardiovascular, hepatic and renal adverse events." | 2.61 | Safety of Paracetamol in Osteoarthritis: What Does the Literature Say? ( Arden, N; Avouac, B; Conaghan, PG; Migliore, A; Rizzoli, R, 2019) |
| "Acetaminophen (APAP) is a highly effective analgesic, which is safe at therapeutic doses." | 2.61 | Acetaminophen hepatotoxicity: A mitochondrial perspective. ( Jaeschke, H; Ramachandran, A, 2019) |
| " There is concern that current NAC dosing is not large enough to adequately treat large APAP ingestions." | 2.61 | Evaluation and treatment of acetaminophen toxicity. ( Curry, SC; Fisher, ES, 2019) |
| " Each non-aspirin OTC analgesic has a distinct adverse event (AE) profile, with GI AE rates for OTC dosing in one study ranging from 37% for diclofenac to 7." | 2.58 | Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics. ( Moore, N; Scheiman, JM, 2018) |
| "A significant proportion of cases of acute liver failure (ALF) do not have an identifiable cause; so called "non A-E," "non A, non B, non C," "seronegative" or "indeterminate" hepatitis." | 2.58 | Systematic review: non A-E, seronegative or indeterminate hepatitis; what is this deadly disease? ( Brennan, PN; Donnelly, MC; Simpson, KJ, 2018) |
| "Acute liver failure is a rare condition with high short-term morbidity and mortality." | 2.58 | Classification and Epidemiologic Aspects of Acute Liver Failure. ( Pievsky, D; Pyrsopoulos, NT; Rustgi, N, 2018) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug." | 2.58 | Autophagy and acetaminophen-induced hepatotoxicity. ( Shan, S; Shen, Z; Song, F, 2018) |
| "Drug-induced acute liver failure carries a high morbidity and mortality rate." | 2.55 | Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. ( Jaeschke, H; Woolbright, BL, 2017) |
| "Although 60 years have passed since it became widely available on the therapeutic market, paracetamol dosage in patients with liver disease remains a controversial subject." | 2.53 | Can paracetamol (acetaminophen) be administered to patients with liver impairment? ( Hayward, KL; Irvine, KM; Martin, JH; Powell, EE, 2016) |
| "The etiology and outcomes of acute liver failure (ALF) have changed since the definition of this disease entity in the 1970s." | 2.53 | The changing face of liver transplantation for acute liver failure: Assessment of current status and implications for future practice. ( Donnelly, MC; Hayes, PC; Simpson, KJ, 2016) |
| "Acetaminophen (APAP) is a well-known analgesic and antipyretic drug." | 2.53 | Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. ( Ghanem, CI; Manautou, JE; Mottino, AD; Pérez, MJ, 2016) |
| "Drug-induced liver injury (DILI) represents a serious medical challenge and a potentially fatal adverse event." | 2.53 | Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon? ( Antoine, DJ; Clarke, JI; Dear, JW, 2016) |
| " It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose." | 2.53 | Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity. ( Eugenio-Pérez, D; Montes de Oca-Solano, HA; Pedraza-Chaverri, J, 2016) |
| "Acetaminophen (APAP, paracetamol, N-acetyl-p-aminophenol) is a widely used analgesic that is safe at therapeutic doses but is a major cause of acute liver failure (ALF) following overdose." | 2.52 | Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. ( Coen, M, 2015) |
| "Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure." | 2.52 | Translational biomarkers of acetaminophen-induced acute liver injury. ( Beger, RD; Bhattacharyya, S; Gill, PS; James, LP; Schnackenberg, LK; Sun, J; Yang, X, 2015) |
| "Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States." | 2.52 | Intravenous acetaminophen use in pediatrics. ( Shastri, N, 2015) |
| " One notable exception is acetaminophen (APAP, paracetamol), which is a safe drug at therapeutic doses but can cause severe liver injury and acute liver failure after intentional and unintentional overdoses." | 2.52 | Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients. ( Jaeschke, H, 2015) |
| " Specific and sensitive detection of liver injury is important for the prompt and safe treatment of patients with the antidote N-acetylcysteine (NAC) and for the determination of NAC efficacy." | 2.50 | Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. ( Antoine, DJ; Dear, JW, 2014) |
| " Moreover, there is evidence that the maximum recommended dosage can induce hepatic cytolysis in some individuals." | 2.50 | Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease. ( Fromenty, B; Michaut, A; Moreau, C; Robin, MA, 2014) |
| "Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity." | 2.50 | A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. ( Ben-Joseph, R; Blieden, M; Paramore, LC; Shah, D, 2014) |
| "Acetaminophen overdose has become the leading cause of acute liver failure in the US." | 2.50 | Transcriptomic studies on liver toxicity of acetaminophen. ( Cheng, F; Figler, B; Toska, E; Zagorsky, R, 2014) |
| " Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver." | 2.49 | Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. ( Jaeschke, H; McGill, MR, 2013) |
| "Drug and substance abuse remains a major medical problem." | 2.49 | Liver abnormalities in drug and substance abusers. ( de Boer, B; MacQuillan, G; Pateria, P, 2013) |
| " This drug is, however, effective and safe if notes of caution are applied." | 2.49 | [Paracetamol. Efficacious and safe for all ages]. ( Wehling, M, 2013) |
| "Osteoarthritis (OA) is the most common cause of disability in older adults, and although analgesic use can be helpful, it can also result in adverse drug events." | 2.48 | Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics. ( Hanlon, JT; Marcum, ZA; O'Neil, CK, 2012) |
| " To progress to quantitative dose-response analysis needed for hazard characterization, in hepatic systems toxicology studies, generation of toxicogenomic data of multiple doses/concentrations and time points is required." | 2.47 | Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study. ( Bessems, JG; Driessen, M; Kienhuis, AS; Luijten, M; Peijnenburg, AA; Pennings, JL; van Delft, JH; van der Ven, LT, 2011) |
| "It is now widely appreciated that drug metabolites, in addition to the parent drugs themselves, can mediate the serious adverse effects exhibited by some new therapeutic agents, and as a result, there has been heightened interest in the field of drug metabolism from researchers in academia, the pharmaceutical industry, and regulatory agencies." | 2.47 | Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism. ( Baillie, TA; Rettie, AE, 2011) |
| "Acetaminophen is a leading cause of overdose-related hepatotoxicity." | 2.47 | Intravenous acetylcysteine for the treatment of acetaminophen overdose. ( Doyon, S; Klein-Schwartz, W, 2011) |
| " Alterations in these pharmacokinetic principles have been rarely reported." | 2.46 | Bactrian ("double hump") acetaminophen pharmacokinetics: a case series and review of the literature. ( Burke, CR; Hendrickson, RG; McKeown, NJ; West, PL, 2010) |
| "Acute liver failure is a rare disorder with high mortality and resource cost." | 2.46 | Acute liver failure. ( Auzinger, G; Bernal, W; Dhawan, A; Wendon, J, 2010) |
| " Recent human clinical trials of drugs, including acetaminophen (APAP) and ximelagatran, have shown that the metabonomics of biofluids (plasma and urine) collected before and immediately after dosing can identify individual patients who are likely to develop DILI." | 2.46 | The application of metabonomics to predict drug-induced liver injury. ( O'Connell, TM; Watkins, PB, 2010) |
| "Most anaphylactoid reactions occur at the start of acetylcysteine treatment when concentrations are highest." | 2.45 | Adverse reactions associated with acetylcysteine. ( Bateman, DN; Sandilands, EA, 2009) |
| "Acetaminophen has been widely used for > 50 years in the treatment of pain and fever and provides for the safe and effective relief of these symptoms." | 2.44 | Acetaminophen safety and hepatotoxicity--where do we go from here? ( Amar, PJ; Schiff, ER, 2007) |
| "Acetaminophen is a commonly used antipyretic and analgesic agent." | 2.44 | Acetaminophen hepatotoxicity. ( Larson, AM, 2007) |
| "Paracetamol poisoning is implicated in about 150-200 poisoning deaths per year in England and Wales." | 2.43 | Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review. ( Majeed, A; Morgan, O, 2005) |
| "Acetaminophen poisoning accounts for a disproportionate percentage of all toxic ingestions, and can be life-threatening." | 2.43 | An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. ( Marzullo, L, 2005) |
| " The toxic response to APAP is triggered by a highly reactive metabolite N-acetyl-p-benzoquinone-imine." | 2.43 | Role of innate immunity in acetaminophen-induced hepatotoxicity. ( Kaplowitz, N; Liu, ZX, 2006) |
| "Inflammation is a critical component of the overall pathophysiology, not only as a potential factor that may aggravate cell damage, but more importantly as a vital response to limit cell injury, remove cell debris and promote regeneration." | 2.43 | Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. ( Jaeschke, H, 2005) |
| "The currently recommended dosing scheme for treating acetaminophen overdose in the United States consists of a loading dose of oral N-acetylcysteine 140 mg/kg, followed by 70 mg/kg every 4 hours for 17 doses, for a total of 72 hours of oral N-acetylcysteine therapy." | 2.42 | Acetaminophen intoxication and length of treatment: how long is long enough? ( Kociancic, T; Reed, MD, 2003) |
| "Acetaminophen did not cause hepatic lipid peroxidation in wild-type mice but did cause lipid peroxidation in iNOS knockout mice." | 2.42 | Acetaminophen-induced hepatotoxicity. ( Hinson, JA; James, LP; Mayeux, PR, 2003) |
| " Better dosage forms are also required for rectal administration." | 2.42 | [New perspectives on paracetamol]. ( Prescott, LF, 2003) |
| " We describe a case of toxic hepatitis free of the aforementioned risk factors associated with chronic ingestion of moderately excessive doses of acetaminophen." | 2.41 | Chronic acetaminophen toxicity: a case report and review of the literature. ( Belson, MG; Brown, DK; Lane, JE; Scheetz, A, 2002) |
| " As is true for most all potentially beneficial medicines used in pediatrics, awareness of the actual amount of drug received from all sources and caution to not exceed the age-appropriate dosing guidelines (i." | 2.41 | Acetaminophen intoxication during treatment: what you don't know can hurt you. ( Kearns, GL; Leeder, JS; Wasserman, GS, 2000) |
| " Key search terms included acetaminophen, paracetamol, toxic hepatitis, hepatotoxicity, liver dysfunction, overdose, drug toxicity, and poisoning." | 2.41 | Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors. ( Bolesta, S; Haber, SL, 2002) |
| " Studies performed in both experimental animals and humans indicate that chronic alcohol use leads to a short-term, two- to threefold increase in hepatic content of cytochrome P4502E1, the major isoform responsible for the generation of the toxic metabolite from paracetamol, although increased oxidative metabolism of paracetamol at recommended doses has not been demonstrated clinically." | 2.41 | Alcohol exposure and paracetamol-induced hepatotoxicity. ( Riordan, SM; Williams, R, 2002) |
| " Serum acetaminophen levels for which an estimate of time from last dose could be calculated were available for 30 patients, of which 22 levels were greater than the toxic range described for acute ingestion." | 2.40 | Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. ( Barbacci, MB; Heubi, JE; Zimmerman, HJ, 1998) |
| "Clinical descriptions of fulminant hepatic failure as originally reported, along with the subgroups of subfulminant and late onset hepatic failure identified later, are considered in relation to the proposed new classification of hyperacute, acute, and subacute liver failure." | 2.39 | Classification, etiology, and considerations of outcome in acute liver failure. ( Williams, R, 1996) |
| " In the therapeutic setting of treatment of fever and pain in children, paracetamol is regarded as a drug with a higher therapeutic index, and as such, there seems to be little concern with strict adherence to dosage regimes." | 2.38 | Paracetamol poisoning in children and hepatotoxicity. ( Buchanan, N; Penna, A, 1991) |
| "A potential side effect of paracetamol is its hepatotoxicity." | 2.38 | [Paracetamol hepatotoxicity]. ( Lubec, G, 1990) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| " About 50% of patients given salicylate in full anti-inflammatory dosage develop minor abnormalities of liver function." | 2.37 | Liver damage with non-narcotic analgesics. ( Prescott, LF, 1986) |
| "Acetaminophen has become a very popular over-the-counter analgesic in some countries and as a result it is used increasingly as an agent for self-poisoning." | 2.36 | The treatment of acetaminophen poisoning. ( Critchley, JA; Prescott, LF, 1983) |
| "Acetaminophen is a remarkably safe agent when used in therapeutic doses." | 2.36 | Acetaminophen overdose. ( Rumack, BH, 1983) |
| "Acetaminophen is an effective antipyretic and analgesic with few side effects that is toxic only in massive overdose." | 2.36 | Use of antipyretic analgesics in the pediatric patient. ( Gladtke, E, 1983) |
| " In a double-blind, two-week, cross-over study, no clinical or laboratory evidence of adverse effects was found." | 2.36 | Hepatotoxicity following the therapeutic use of antipyretic analgesics. ( Benson, GD, 1983) |
| "10 Phenylbutazone may cause liver injury and other analgesics can cause hypersensitivity reactions in which the liver is involved." | 2.36 | Hepatotoxicity of mild analgesics. ( Prescott, LF, 1980) |
| "Acetaminophen is an analgesic that is frequently used in Canada, and the occurrence of overdoses with this drug seems to be increasing." | 2.36 | Treatment of acetaminophen poisoning. ( Freedman, F; Sellers, EM, 1981) |
| " Clinical trial evidence supporting shorter NAC dosing now allows the possibility for intensifying treatment without the risk of very high rates of ADRs." | 1.91 | Large paracetamol overdose-Higher dose acetylcysteine is required. ( Bateman, DN, 2023) |
| " The results showed that in the 3-hour period there was an increase in creatinine dosage and lipid peroxidation (TBARS) compared to the control group." | 1.91 | Temporal analysis of paracetamol-induced hepatotoxicity. ( Coelho, AM; Costa, DC; Lima, WG; Oliveira de Souza, M; Perucci, LO; Queiroz, IF; Talvani, A, 2023) |
| " In mice, acute liver injury induced by orally dosing APAP (500 mg/kg) was severely exacerbated by Gpbar1 gene ablation and attenuated by anti-Cysltr1 small interfering RNA pretreatment." | 1.91 | Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury. ( Bellini, R; Biagioli, M; Bordoni, M; Cassiano, C; Catalanotti, B; di Giorgio, C; Distrutti, E; Fiorillo, B; Fiorucci, S; Marchianò, S; Monti, MC; Roselli, R; Sepe, V; Zampella, A, 2023) |
| "Pretreatment with nicorandil reduced serum levels of aminotransferases, bilirubin, GGT and LDH, and increased serum level of albumin." | 1.91 | Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis. ( El-Kashef, DH; Sharawy, MH, 2023) |
| "Fomepizole is a promising new treatment for preventing liver injury following paracetamol (acetaminophen) overdose." | 1.91 | Fomepizole should not be used more liberally in paracetamol overdose. ( Dear, JW, 2023) |
| " The literature shows that excessive or long-term use of APAP can lead to increased cardiovascular dysfunction." | 1.91 | Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease. ( Feng, X; Fu, D; Hu, C; Huang, Y; Jiang, X; Li, Y; Wen, J; Wu, S; Xin, J; You, T, 2023) |
| "Acetaminophen was the most common causative agent." | 1.91 | Drug induced liver injury: causative agents and predictors for the outcome - a retrospective study at Tanta University Hospital, Egypt. ( Elbastawesy, SM; Elkadeem, M; Helal, NE; Mashaal, SA, 2023) |
| " Statistically significant changes were found by comparing bile acid profiles between dosing levels." | 1.91 | Semi-Targeted Profiling of Bile Acids by High-Resolution Mass Spectrometry in a Rat Model of Drug-Induced Liver Injury. ( Mireault, M; Ohlund, L; Prinville, V; Sleno, L, 2023) |
| "Acetaminophen (APAP) is a widely used analgesic drug, but its over-dose is associated with acute liver failure where the clinical approved antidote treatment is limited." | 1.91 | Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition. ( Chang, D; He, Y; Huang, M; Li, S; Lin, Y; Liu, W; Xu, W; Zhang, Q; Zhao, R; Zheng, Y; Zhou, X, 2023) |
| "Abietic acid has been known to exhibit anti-inflammatory activity." | 1.91 | Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. ( An, Y; Guan, L; Han, D; Luo, Q, 2023) |
| "Fisetin was administered at 25 and 50 mg/kg doses." | 1.91 | Fisetin Attenuates Paracetamol-Induced Hepatotoxicity by Regulating CYP2E1 Enzyme. ( Cadirci, E; Cinar, I; Gurbuz, MA; Ugan, RA; Un, H, 2023) |
| "Acetaminophen (APAP) may cause acute liver injury with therapeutic doses in high-risk conditions such as chronic alcohol consumption or malnutrition." | 1.91 | Association between adverse outcomes of hepatitis A and acetaminophen use: A population-based cohort study. ( Chung, JW; Jang, ES; Kim, JW; Park, GC, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood." | 1.91 | Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. ( Clayton, NP; Cortes, RA; Izawa, T; Pandiri, AR; Sills, RC; Travlos, GS, 2023) |
| "Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is recognized as the most common cause of ALF in Western societies." | 1.91 | Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice. ( Anderson, CD; Huffman, AM; Rezq, S; Romero, DG; Syed, M; Yanes Cardozo, LL, 2023) |
| "Acetaminophen (APAP) is an over-the-counter antipyretic analgesic that exhibits high hepatotoxicity when used for long-term or in overdoses." | 1.91 | Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments. ( Ge, B; Kong, L; Liu, X; Sang, R; Wang, W; Yan, K; Yu, M; Yu, Y; Zhang, X, 2023) |
| "During the outbreak of COVID19 measures taken to contain the spread of the virus have influenced the mental well-being of adults and adolescents." | 1.91 | Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning. ( Capossela, L; Chiaretti, A; Curatola, A; Ferretti, S; Gatto, A; Graglia, B; Pansini, V, 2023) |
| "Leonurine (Leo) is a natural alkaloid isolated from the herb Leonurus japonicus Houtt." | 1.91 | Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice. ( Chen, Y; Di, S; Huang, X; Wang, Y; Yu, Y; Zhou, S, 2023) |
| "Acetaminophen is a pharmaceutical synthesized non-opioid analgesic that belongs to the "aniline analgesics" class of medicine." | 1.91 | Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats. ( Ahmed Mohammed, R; Fadheel, QJ, 2023) |
| "Acetaminophen (APAP) is one of the world's popular and safe painkillers, and overdose can cause severe liver damage and even acute liver failure." | 1.91 | Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway. ( Cao, C; Ci, X; Fan, X; Hou, W; Li, K; Zhu, L, 2023) |
| " As a result, this study shows that subtoxic dose of APAP treatment alone or in combination with acute or exhaustive treadmill exercise can cause oxidative liver damage by affecting Sirt1 levels and without affecting VEGF levels." | 1.91 | The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats. ( Acikgoz, O; Aksu, I; Gencoglu, C; Kiray, M; Tas, A, 2023) |
| "Acetaminophen (APAP) is a common antipyretic and analgesic drug that can cause long-term liver damage after an overdose." | 1.91 | Caveolin-1 protects against liver damage exacerbated by acetaminophen in non-alcoholic fatty liver disease by inhibiting the ERK/HIF-1α pathway. ( Fu, D; Hu, C; Huang, Y; Jiang, X; Jin, L; Li, B; Li, Y; Wu, S; Xin, J; You, T, 2023) |
| "Fucoxanthin (FUC) is an allenic carotenoid that is found in edible brown seaweeds, and it has antioxidant and anti-inflammatory effects." | 1.91 | Antioxidative and Anti-Inflammatory Protective Effects of Fucoxanthin against Paracetamol-Induced Hepatotoxicity in Rats. ( Al-Amodi, HS; Almaimani, RA; Althubiti, M; Eid, SY; El-Readi, MZ; Elzubier, ME; Idris, S; Koshak, MF; Refaat, B, 2023) |
| "Fomepizole has proven safety in methanol and ethylene glycol poisoning and is a potent CYP2E1 and c-Jun-N-terminal Kinase (JNK) inhibitor that is effective even in the metabolic phase." | 1.72 | Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. ( Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ, 2022) |
| "Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries." | 1.72 | Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. ( Jaeschke, H; Nguyen, NT; Ramachandran, A; Sanchez-Guerrero, G; Umbaugh, DS, 2022) |
| " The integrated UPLC-Q-TOF/MS, pharmacodynamic study, histopathological combination with network pharmacology and molecular docking technology were used to explore the potential mechanisms." | 1.72 | Network pharmacology, molecular docking technology integrated with pharmacodynamic study to reveal the potential targets of Schisandrol A in drug-induced liver injury by acetaminophen. ( Deng, S; Ge, J; Li, J; Li, M; Li, X; Ma, L; Ma, Y; Zhang, J; Zheng, Y, 2022) |
| " Administration groups were pretreated with high and low-dose dry dandelion extract (1,000 or 500 g fresh herb dried and then decocted into 120 mL solution, DDE-H and DDE-L); low-, medium- and high-dose dandelion juice (250, 500, 1,000 g/120 mL, DJ-L, DJ-M, and DJ-H); fresh dandelions evaporation juice water (120 mL, DEJW); dry dandelion extract dissolved by pure water (1 kg/120 mL, DDED-PW); dry dandelion extract dissolved by DEJW (120 g/120 mL, DDED-DEJW) by oral gavage for 7 days at the dosage of 0." | 1.72 | Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury. ( Ai, J; Deng, X; Lei, L; Li, YQ; Liang, S; Pu, SB; Ren, YS; Zhang, TP; Zheng, Y, 2022) |
| " RNA-sequencing analysis suggested that Utx deficiency in female mice upregulated antitoxic phase II conjugating enzymes, including sulfotransferase family 2 A member 1 (Sult2a1), thus reduces the amount of toxic APAP metabolites in injured liver; while Utx deficiency also alleviated ER stress through downregulating transcription of ER stress genes including Atf4, Atf3, and Chop." | 1.72 | Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms. ( Chen, H; Chen, X; Huang, K; Huang, Y; Wang, Q; Wu, D; Xie, Y; Xiong, M; Yang, D; Zheng, L, 2022) |
| " Pirfenidone (PFD), an orally bioavailable pyridone derivative, is clinically used for idiopathic pulmonary fibrosis treatment and has antifibrotic, anti-inflammatory, and antioxidant effects." | 1.72 | Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation. ( Aoyagi, T; Goya, T; Imoto, K; Kato, M; Kohjima, M; Kurokawa, M; Kuwano, A; Ogawa, Y; Suzuki, H; Takahashi, M; Tanaka, M; Tashiro, S, 2022) |
| "Poncirin treatment also improved the liver function tests and liver synthetic activity compared to paracetamol treated group." | 1.72 | Comprehensive in vivo and in silico approaches to explore the hepatoprotective activity of poncirin against paracetamol toxicity. ( Ahmad, S; Ali, H; Bibi, T; Khan, A; Khan, S; Seo, EK; Shehzad, O; Ullah, H, 2022) |
| "Paracetamol is a popular and safe drug preferred by victims of pain or pyrexia; however, its overdose or abuse is a growing concern worldwide." | 1.72 | Drynaria quercifolia suppresses paracetamol‑induced hepatotoxicity in mice by inducing Nrf-2. ( Bhattacharjee, S; Bhattacharya, S; Chatterjee, S; Choudhury, PR; Mandal, DP; Rahaman, A; Sarkar, A; Talukdar, AD, 2022) |
| " Additionally, the role of nutrition status on the pharmacokinetic profile of acetaminophen (APAP) at toxic doses is either scanty or not available." | 1.72 | The effect of nutritional status on the pharmacokinetic profile of acetaminophen. ( Badanthadka, M; Mamatha, BS; Shetty, M; Souza, VD; Vijayanarayana, K, 2022) |
| " Although it is well known that APAP-induced liver injury (AILI) is caused by toxic mechanism, recently it is also reported to be immune related." | 1.72 | Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury. ( Furukawa, Y; Hattori, T; Ijiri, Y; Kato, R; Noda, T; Tanaka, K, 2022) |
| " We identified a mechanism by which acetaminophen overdose causes an increase in bile acid concentrations (to above toxic thresholds) in hepatocytes." | 1.72 | Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. ( Akakpo, JY; Begher-Tibbe, B; Brackhagen, L; Brecklinghaus, T; Canbay, A; Copple, IM; Curry, SC; Friebel, A; Ghallab, A; Goldring, C; González, D; Hassan, R; Hengstler, JG; Hobloss, Z; Hoehme, S; Hofmann, U; Jaeschke, H; Kappenberg, F; Longerich, T; Luedde, T; Marchan, R; Murad, W; Myllys, M; Olyaee, M; Overbeck, N; Rahnenführer, J; Reinders, J; Schreiter, T; Seddek, AL; Sezgin, S; Sowa, JP; Trauner, M; Urban, S; Vucur, M; Zühlke, S, 2022) |
| "Acetaminophen (APAP) is a widely consumed drug for pain management and treatment of pyrexia." | 1.72 | Ameliorative effect of Spatoglossum asperum and its solvent fractions against acetaminophen-induced liver dysfunction in rats. ( Ara, J; Azam, M; Ehteshamul-Haque, S; Khan, H; Qureshi, SA; Tariq, A, 2022) |
| "Acetaminophen (APAP) can cause acute liver failure, but treatment options are still limited." | 1.72 | Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation. ( Kim, GM; Kim, JY; Leem, J, 2022) |
| "Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic medication." | 1.72 | Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal. ( Harahsheh, E; Hussein, S; Mohamed Kamel, GA, 2022) |
| "Gastrodin is a major active phenolic glycoside extract from Gastrodia elata, an important herb used in traditional medicine." | 1.72 | Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways. ( Chou, AH; Hu, LM; Lee, HC; Liao, CC; Liu, FC; Yu, HP, 2022) |
| "Acetaminophen (APAP) is a common drug causing DILI." | 1.72 | Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte. ( Cao, Y; Cheng, L; Gao, Z; Wang, L; Wang, T; Wu, W; Zhang, Q, 2022) |
| "Ferulic acid (FA) is a natural polyphenol compound existing in many plants that has free radical scavenging, anti-inflammatory, and liver-protective properties." | 1.72 | Ferulic acid ameliorates acetaminophen-induced acute liver injury by promoting AMPK-mediated protective autophagy. ( Fan, G; Li, X; Lin, S; Liu, J; Lyu, X; Wang, Y; Wu, J; Xue, X; Zhou, F, 2022) |
| "Acetaminophen (APAP) is a relatively safe analgesic drug, but overdosing can cause acute liver failure." | 1.72 | The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency. ( Fujii, J; Homma, T; Itoh, H; Kawamae, K; Kimura, S; Kobayashi, S; Miyata, S; Nakane, M; Osaki, T, 2022) |
| " Most importantly, the dose-response effects and time course of APAP accumulation and metabolism agree well with those of the liver injury development." | 1.72 | Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning. ( Chen, Y; Ge, W; Song, W; Yan, R, 2022) |
| " Genetic variation associated with acetaminophen-induced alanine aminotransferase elevation during therapeutic dosing has not been examined." | 1.72 | Genetic variants associated with ALT elevation from therapeutic acetaminophen. ( Arriaga Mackenzie, I; Dart, RC; Heard, KJ; Kaiser, S; Monte, AA; Pattee, J; Reynolds, KM; Rumack, B; Willems, E, 2022) |
| "Acetaminophen (APAP) is a frequently used painkiller, and hepatotoxic side effects limit its use." | 1.72 | Exploration of the Protective Mechanism of Naringin in the Acetaminophen-Induced Hepatic Injury by Metabolomics. ( Cai, Y; Chen, B; Gu, W; Li, M; Lin, Z; Liu, W; Shen, Z; Wan, CC; Wang, G; Yan, T; Zhao, S; Zheng, G, 2022) |
| "The encapsulation of three drug components in the emulsion can improve the oral bioavailability to varying degrees and can effectively prevent the acute liver injury caused by acetaminophen." | 1.72 | [Preparation of salvianolic acid B, tanshinone Ⅱ_A, and glycyrrhetinic acid lipid emulsion and its protective effect against acute liver injury induced by acetaminophen]. ( Gu, H; Lin, T; Wang, XJ; Wang, XL; Zhang, XR, 2022) |
| "Naringin (Nar) has been reported to exert potential hepatoprotective effects against acetaminophen (APAP)-induced injury." | 1.72 | Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro. ( Bi, Y; Chen, Y; Duan, Z; Guo, W; Li, Z; Wu, Q; Yu, P, 2022) |
| "Although N-acetyl-cysteine (NAC) has long been used for the treatment of acetaminophen poisoning/overdose, the optimal NAC dosing regimen for varying patterns or severity of the poisoning/overdose is still unknown." | 1.72 | Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. ( Janković, SM, 2022) |
| "Rosiglitazone pretreatment can alleviate APAP-induced ALI by suppressing three branches of ERS signaling." | 1.72 | Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways. ( Cao, Y; He, W; Huang, J; Li, X; Wang, J, 2022) |
| "Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models." | 1.72 | Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin. ( Abdel Kader, DH; Al-Ani, B; Dallak, M; Dawood, AF; Eid, RA; Haidara, MA; Kamar, SS; Shams Eldeen, AM, 2022) |
| "Acetaminophen (APAP) is a well-known antipyretic and analgesic medicine." | 1.72 | Role of cinnamon oil against acetaminophen overdose induced neurological aberrations through brain stress and cytokine upregulation in rat brain. ( Alam, MI; Alshahrani, S; Ashafaq, M; Hussain, S; Islam, F; Khuwaja, G; Madkhali, O; Siddiqui, R, 2022) |
| "Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1)." | 1.72 | Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway. ( Chen, G; Cheng, Z; Han, L; Liu, Q; Shen, P, 2022) |
| " APAP is safe at therapeutic levels, however, an overdose can cause severe liver injury." | 1.62 | Potential benefits of using hydrogen sulfide, vitamin E and necrostatin-1 to counteract acetaminophen‑induced hepatotoxicity in rats. ( Abdel-Hakeem, EA; El-Tahawy, NF; Elbassuoni, EA; Saad, AH; Saleh, NEH, 2021) |
| "We analyzed postoperative pain intensity, the incidence rate of acute kidney injury, drug-induced liver injury, and rate of elevation in serum creatinine after open radical prostatectomy." | 1.62 | Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis. ( Hamada, S; Hamada, Y; Hara, K; Kadowaki, D; Miyamura, S; Nishimura, F; Nojima, M; Oniki, K; Saruwatari, J; Ushijima, T, 2021) |
| "Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases." | 1.62 | CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021) |
| "Acetaminophen treatment obviously increased the levels of ALT and AST, changed hepatic histopathology, promoted oxidative stress, decreased antioxidant enzyme activities, and elevated the pro-inflammatory cytokines." | 1.62 | Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice. ( Chen, C; Li, B; Thida, M; Zhang, X, 2021) |
| " We illustrate that insufficient sulfation leads to a shift in biotransformation of paracetamol to toxic oxidation pathways and patients with low sulfate reserves are at higher risk of paracetamol toxicity." | 1.62 | Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose. ( Chiew, AL; Duffull, SB; Isbister, GK; Li, J, 2021) |
| "Liver failure is a serious hepatic dysfunction with high mortality." | 1.62 | Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats. ( Chen, L; Chen, X; Jiang, H; Li, L; Lv, L; Wang, K; Wang, Q; Yan, R, 2021) |
| "Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI." | 1.62 | Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. ( Ezhilarasan, D; Raghunandhakumar, S, 2021) |
| "This study examined the associations of sleep disorders with APAP-induced adverse reactions or liver injury and the possible mechanisms." | 1.62 | Sleep disorders are associated with acetaminophen-induced adverse reactions and liver injury. ( Fan, X; Han, Q; Li, N; Liu, Z; Wang, X; Zeng, L; Zhang, K; Zhang, X, 2021) |
| "Acetaminophen (APAP) is a commonly used pain and fever reliever but is also the most frequent cause of drug-induced liver injury." | 1.62 | A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity. ( Shin, DJ; Tran, M; Wang, L; Wu, J, 2021) |
| "Acetaminophen (APAP) is a widely used analgesic and is safe at therapeutic doses." | 1.62 | Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice. ( Akakpo, JY; Ding, WX; Jaeschke, H; Nguyen, NT; Ramachandran, A; Weemhoff, JL, 2021) |
| " Our results showed that toll-like receptor 5 (TLR5) was abundantly expressed in hepatocytes and dramatically downregulated in the toxic mouse livers." | 1.62 | Exogenous activation of toll-like receptor 5 signaling mitigates acetaminophen-induced hepatotoxicity in mice. ( Jeong, H; Kim, B; Kim, JW; Lim, CW; Qi, J; Yang, D; Yang, MS; Zhou, Z, 2021) |
| " Our results clarified that Paracetamol toxicity caused significant adverse effects on hematological, serum biochemical parameters, and oxidant -antioxidant status as well as histopathological picture of heart, liver, and kidney." | 1.62 | Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats. ( Alkhalifah, DHM; Assar, DH; Elkaw, EM; Hamouda, RA; Hamza, HA; Hozzein, WN; Latif, AAE, 2021) |
| "Recent recognition of "massive" acetaminophen (APAP) overdoses has led to the question of whether standard dosing of N-acetylcysteine (NAC) is adequate to prevent hepatoxicity in these patients." | 1.62 | Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. ( Cumpston, KL; Downs, JW; Kershner, EK; Rose, SR; Troendle, MM; Wills, BK, 2021) |
| "Acetaminophen has been increasingly used in treating patent ductus arteriosus (PDA) in preterm neonates." | 1.62 | Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. ( Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Hasan, SJR; Hubail, Z; Sridharan, K, 2021) |
| " These results reveal an FXR-DCA-TNF-α axis that potentiates APAP hepatotoxicity, which could guide the clinical safe use of APAP." | 1.62 | FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity. ( Gonzalez, FJ; Hao, H; Krausz, KW; Luo, Y; Takahashi, S; Wang, G; Wang, H; Yagai, T; Yan, N; Yan, T; Zhao, M, 2021) |
| "Acetaminophen is a commonly used analgesic and antipyretic, with the potential to cause significant injury when ingested in toxic amounts." | 1.62 | Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used? ( Akpunonu, P; Bailey, AM; Baum, RA; Geraghty, L; Howell, MM; Mohan, S; Su, MK; Weant, KA; Webb, AN; Woolum, JA, 2021) |
| "Fasudil is an inhibitor of Rhoa/ROCK signaling, which is involved in anti-inflammatory and anti-injury effects." | 1.62 | Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway. ( Li, X; Lu, L; Meng, T; Ren, X, 2021) |
| "APAP toxicity model was implemented by administering a toxic dose of APAP." | 1.62 | The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats. ( Atalay, O; Celik, E; Cicek, Z; Kubat, GB; Ozler, M; Suvay, S; Ulger, O, 2021) |
| "Acetaminophen is a common cause of poisoning and liver injury worldwide; however, patient stratification is suboptimal." | 1.62 | Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study. ( Deye, N; Diallo, A; Gourlain, H; Goury, A; Malissin, I; Mégarbane, B; Nuzzo, A; Péron, N; Salem, S; Vicaut, E; Voicu, S, 2021) |
| " The results of this study suggest a new toxic mechanism of acetaminophen-induced liver injury in patients with acatalasemia." | 1.62 | Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice. ( Eitoku, M; Matsuura-Harada, Y; Nagaoka, K; Ogino, K; Ogino, N; Suganuma, N; Tomizuka, K, 2021) |
| " Intraperitoneal or po administration of the new chemical entities (NCEs), 3b and 3r, in concentrations equal to a toxic dose of ApAP did not result in the formation of NAPQI." | 1.56 | A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis. ( Abet, V; Alvarez-Builla, J; Bazan, HA; Bazan, NG; Bhattacharjee, S; Burgos, C; Edwards, S; Gordon, WC; Heap, J; Jun, B; Ledet, AJ; Pahng, AR; Paul, D; Recio, J, 2020) |
| "Pelargonidin is an anthocyanidin found in pomegranates, plums, and various berries." | 1.56 | Pelargonidin ameliorates acetaminophen-induced hepatotoxicity in mice by inhibiting the ROS-induced inflammatory apoptotic response. ( Kim, H; Lee, JH; Park, JW; Seo, M, 2020) |
| "Acetaminophen is a common analgesic-antipyretic agent, which is safe in therapeutic doses but in higher doses can produce hepatic necrosis." | 1.56 | Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity in mice. ( Abdou, AG; Elsayed Elgarawany, G; Maher Taie, D; Motawea, SM, 2020) |
| "Acetaminophen toxicity has been associated with elevation of microRNAs." | 1.56 | Circulating microRNA Profiles in Acetaminophen Toxicity. ( Ambros, V; Carreiro, S; Chapman, B; Lee, R; Marvel-Coen, J, 2020) |
| "Acetaminophen (APAP) is a commonly used over-the-counter drug for its analgesic and antipyretic effects." | 1.56 | Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1 ( Chen, L; Manautou, JE; Wang, P; Zhong, XB, 2020) |
| "The allicin-treated group received allicin orally (10 mg/kg/d) during 7 days before APAP injection." | 1.56 | Hepatoprotective effect of allicin against acetaminophen-induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration. ( El-Sheakh, AR; Hamed, MF; Samra, YA, 2020) |
| "Apigenin (API) is a natural flavonoid abundant in fruits and vegetables." | 1.56 | Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats: Targeting oxidative stress, STAT3, and apoptosis signals. ( Abd El-Raouf, OM; Kotb, AS; Mohamed, WR; Mohammad Fikry, E, 2020) |
| "Acetaminophen (APAP) was used as a model drug to induce DILI in C57BL/6J mice at different ages of days 10 (infant), 22 (child), and 60 (adult)." | 1.56 | Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver. ( Bao, Y; Ma, X; Manautou, JE; Shao, X; Shi, J; Wang, P; Xiao, J; Zhang, L; Zhong, XB; Zhu, HJ; Zhu, J, 2020) |
| "Acetaminophen has been increasingly used for the treatment of cancer-related pain in Japan since the revision of the package insert on January 21, 2011." | 1.56 | Risk Factors for Acetaminophen-induced Liver Injury: A Single-center Study from Japan. ( Hidaka, N; Kaji, Y; Matsuoka, I; Takatori, S; Tanaka, A; Tanaka, M, 2020) |
| "Acetaminophen (APAP) overdose-induced acute liver failure is an important clinical problem in the United States and the current antidote N-acetylcysteine, has a short early therapeutic window." | 1.56 | Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model. ( Duan, L; Jaeschke, H; Ramachandran, A; Woolbright, BL, 2020) |
| " HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined." | 1.56 | New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. ( Devière, J; Dressen, C; Gustot, T; Leclercq, I; Lemmers, A; Liefferinckx, C; Minsart, C; Moreau, R; Quertinmont, E, 2020) |
| "Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies." | 1.56 | Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020) |
| " The present study evaluated the feasibility of integrating in vitro data from three-dimensionally (3D)-cultured HepaRG cells and physiologically based pharmacokinetic (PBPK) modeling to predict chemical-induced liver toxicity." | 1.56 | Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity. ( Carmichael, PL; Guo, J; Li, F; Li, J; Li, W; Li, Y; Peng, H; Peng, S; Wang, Y; Yu, L; Zhang, C; Zhang, Q; Zhao, J, 2020) |
| " Drug-induced toxicity can be relieved by several natural products, which are preferred due to their dietary nature and less adverse reactions." | 1.56 | Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway. ( Abo El-Magd, NF; Eraky, SM, 2020) |
| "Some patients encounter hepatotoxicity after repeated acetaminophen (APAP) dosing even at therapeutic doses." | 1.56 | Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats. ( Hashimoto, T; Kobayashi, A; Kondo, K; Sugai, S; Suzuki, Y; Takahashi, T; Toyoda, K; Yamada, N; Yoshinari, K, 2020) |
| "N-Acetylcysteine (NAC) is an effective antidote for the treatment of acetaminophen (APAP) poisoning; however, due to its low stability and bioavailability, repeated dosing of NAC is needed." | 1.56 | Improvement of therapeutic potential N-acetylcysteine in acetaminophen hepatotoxicity by encapsulation in PEGylated nano-niosomes. ( Azandaryani, MT; Firozian, F; Karami, S; Nili-Ahmadabadi, A; Ranjbar, A, 2020) |
| " As herbal preparations may interact with pharmaceutical drugs the following in vitro study was undertaken to determine whether the toxic effects of paracetamol on liver cell growth in culture would be exacerbated by the addition of psoralen, a furanocoumarin compound that is present in Psoralea corylifolia, a common Chinese herb." | 1.56 | Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound. ( Britza, SM; Byard, RW; Musgrave, IF, 2020) |
| "Baicalin has already been reported to alleviate acetaminophen (APAP)-induced acute liver injury in our previous study." | 1.56 | Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation. ( Bai, Q; Hu, F; Huang, Z; Ji, L; Lu, B; Shi, L; Wei, M; Zhang, S; Zhang, T, 2020) |
| "Acetaminophen has a remarkable safety profile when prescribed in proper therapeutic doses, but hepatotoxicity can occur when misused or after an overdose." | 1.56 | Late Diagnosis of Paracetamol Poisoning is Always Lethal in Young Adult. ( Aamir, M; Fatima, S; Naz, S, 2020) |
| "Acetaminophen (APAP) is a commonly used analgesic." | 1.56 | Hepatoprotective Activity of Yellow Chinese Chive against Acetaminophen-Induced Acute Liver Injury via Nrf2 Signaling Pathway. ( Hatanaka, T; Kawakami, K; Moritani, C; Suzaki, E; Tsuboi, S, 2020) |
| "Benzophenone glycosides are a major type of polyphenols present in guava." | 1.56 | Guavinoside B from ( Huang, X; Li, D; Li, L; Li, Y; Ma, H; Mu, Y; Xu, J, 2020) |
| " baseline glutathione (GSH) levels, pharmacokinetics, and capacity of hepatic antioxidants) leads to potential differences in carcinogenic hazard potential at different dosing schemes: maximum labeled doses of 4 g/day, repeated doses above the maximum labeled dose (>4-12 g/day), and acute overdoses of acetaminophen (>15 g)." | 1.56 | Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. ( Atillasoy, E; Eichenbaum, G; Gebremichael, Y; Gelotte, CK; Howell, BA; Jacobson-Kram, D; Jaeschke, H; Kuffner, E; Lai, JCK; Murray, FJ; Wikoff, D; Yang, K, 2020) |
| "8) against the toxic group (51." | 1.56 | Hepatoprotective and antioxidant activity of Dicliptera bupleuroides Nees. extracts on paracetamol induced hepatotoxicity in rats. ( Akbar, S; Bushra, R; Ghayas, S; Hussain, K; Ishtiaq, S, 2020) |
| "Methanol extract was found to be the most potent in in-vitro antioxidant studies." | 1.56 | Hepatoprotective effect of Ziziphus oxyphylla Edgew in paracetamol-induced hepatotoxic rat model. ( Akhtar, MS; Anjum, I; Awan, AF; Fatima, A; Haider, SI; Khan, MUR; Mushtaq, MN, 2020) |
| "Acetaminophen (APAP) is a clinically popular analgesic and antipyretic drug, but excessive APAP can cause fatal hepatotoxicity." | 1.56 | Effects of Photoperiod on Acetaminophen-Induced Hepatotoxicity in Mice. ( Cai, J; Cheng, Y; Fan, C; Gao, H; Lin, T; Lu, J; Pu, D; Sun, Y; Wan, Z; Wang, H; Zhang, R, 2020) |
| "Nonalcoholic fatty liver disease (NAFLD) prevails in obesity and is linked to several health complications including dyslipidemia and atherosclerosis." | 1.51 | The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. ( Aldow, M; Barbier, O; Beaulieu, MJ; Camiré, É; Caron, A; Festuccia, WT; Gélinas, Y; Guénard, F; Joubert, P; Jubinville, É; Kaci, I; Karvellas, CJ; Labbé, SM; Lamothe, J; Laplante, M; Marette, A; Mitchell, PL; Morissette, MC; Mouchiroud, M; Rose, CF; Roy, C; Trottier, J; Turcotte, L; Varin, TV, 2019) |
| " The reductions in CYP-mediated acetaminophen bioactivation and uptake transporter, as well as enhanced antioxidant enzyme activity, may limit the accumulation of toxic products in the liver and thus lower hepatotoxicity." | 1.51 | Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats. ( Chang, CH; Li, CC; Yao, HT, 2019) |
| " One of the biggest problems of these compounds, however, is their very short bioavailability due to instant metabolism and rapid excretion." | 1.51 | Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury. ( Ibayashi, Y; Lee, Y; Nagasaki, Y; Ngo, DN; Nishikawa, Y; Vong, LB, 2019) |
| "Acetaminophen was found to significantly alter body weight, serum biochemistry, and hematological indices of mice, which were ameliorated by the co-administration of aqueous extract." | 1.51 | Effects of phenolic compounds from aqueous extract of Trifolium repens against acetaminophen-induced hepatotoxicity in mice. ( Ahmad, S; Zeb, A, 2019) |
| "Acetaminophen (APAP)-induced acute liver failure (ALF) is a life-threatening disease with only a few treatment options available." | 1.51 | Liver-specific Bid silencing inhibits APAP-induced cell death in mice. ( Dames, S; Kuhla, A; Maxa, M; Schaeper, U; Vollmar, B, 2019) |
| "Acetaminophen is a widely available analgesic and antipyretic medication." | 1.51 | [Acetaminophen poisonings hospitalized at the Pomeranian Center of Toxicology in 2010-2015]. ( Garczewski, B; Sein Anand, J; Waldman, W; Wiśniewski, M, 2019) |
| "Acetaminophen (paracetamol) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses." | 1.51 | Kaurenoic acid extracted from Sphagneticola trilobata reduces acetaminophen-induced hepatotoxicity through inhibition of oxidative stress and pro-inflammatory cytokine production in mice. ( Arakawa, NS; Borghi, SM; Bussmann, AJC; Casagrande, R; Fattori, V; Hirooka, EY; Lourenco-Gonzalez, Y; Marcondes-Alves, L; Verri, WA, 2019) |
| " With the increasing administration of intravenous (IV) paracetamol, there will be the associated risk of medication dosing errors." | 1.51 | Intravenous Paracetamol Overdose: A Pediatric Case Report. ( Arslan, D; Aslan, N; Bilen, S; Horoz, OO; Yildizdas, D; Yilmaz, HL, 2019) |
| " Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1 (CYP2E1)." | 1.51 | Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin. ( Gu, J; Kong, X; Sun, X; Sun, Y; Tong, Y; Wang, C; Wang, K; Wen, Y; Wu, H; Xia, Q; Yu, C, 2019) |
| "As an analgesic and antipyretic drug, acetaminophen (APAP) is commonly used and known to be safe at therapeutic doses." | 1.51 | GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation. ( Lei, X; Li, C; Li, X; Mao, Y; Ming, Y; Tang, Y; Wang, Z; Xu, D; Xu, Q; Yao, L, 2019) |
| "Acetaminophen is a mild analgesic and antipyretic agent, which can cause centrilobular hepatic necrosis in toxic doses, whereas alcohol causes death due to liver diseases." | 1.51 | Pharmacokinetic changes of tramadol in rats with hepatotoxicity induced by ethanol and acetaminophen in perfused rat liver model. ( Ardakani, YH; Esmaeili, Z; Ghazi-Khansari, M; Hassanzadeh, G; Lavasani, H; Mohammadi, S; Nezami, A; Rouini, MR, 2019) |
| " Generation of GSH, its conjugation with the toxic NAPQI and the spatial distribution of CYP450 combined together determine the toxicity of APAP." | 1.51 | A spatial-temporal model for zonal hepatotoxicity of acetaminophen. ( Ho, H; Means, SA, 2019) |
| "Acetaminophen, APAP, is a common over-the-counter drug with antipyretic-analgesic action." | 1.51 | Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue. ( Abdeen, A; Abdel-Daim, M; Abdelkader, A; Abdo, M; Aboubakr, M; Aleya, L; Wareth, G, 2019) |
| "Acetaminophen (APAP) was widely used in clinical treatment, although commonly acknowledged that it is a general material that caused drug-related hepatotoxicity." | 1.51 | Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice. ( Cai, E; Li, H; Li, P; Liu, J; Yin, Y; Zhang, Y; Zhao, Y; Zhu, H, 2019) |
| "In acetaminophen-treated mice we detected flow reduction localized to pericentral regions." | 1.51 | A simple automated method for continuous fieldwise measurement of microvascular hemodynamics. ( Clendenon, JL; Clendenon, SG; Dunn, KW; Filson, AJ; Fu, X; Glazier, JA; Klaunig, JE; Mang, H; Martinez, M; Sluka, JP; Von Hoene, RA; Winfree, S, 2019) |
| "Dimethyl fumarate (DMF) is a potent activator of (Nrf-2), its anti-inflammatory and antioxidant properties of DMF have been highlighted recently." | 1.51 | Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway. ( Abdel-Rahman, N; Abdelrahman, RS, 2019) |
| " Seven-day pretreatment with PYC suppressed elevation of CYP2E1 protein expression induced by administration of toxic dose of acetaminophen." | 1.51 | Hepatoprotective and antioxidant potential of Pycnogenol® in acetaminophen-induced hepatotoxicity in rats. ( Borišev, I; Bukumirović, N; Čabarkapa, V; Čapo, I; Mikov, M; Milić, N; Miljković, D; Paut Kusturica, M; Rašković, A; Stilinović, N, 2019) |
| "Acetaminophen was undetectable in serum samples from 227 patients (52%)." | 1.51 | Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose. ( Gottfried, M; Hameed, B; Lee, WM; Leventhal, TM; Olson, JC; Subramanian, RM, 2019) |
| "Shikonin is a natural product with antioxidant and anti-inflammatory activities." | 1.51 | Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. ( Chen, F; Guo, H; Hu, Y; Hua, H; Jia, Z; Jing, X; Li, D; Sun, J; Xu, J; Yu, X, 2019) |
| "Fisetin (FST) is a phenolic compound that has been isolated from many natural products." | 1.51 | Protective effect of 7,3',4'-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo. ( Chen, L; Hu, C; Jia, Y; Liu, X; Pan, L; Wang, Y; You, L; Zhang, J; Zhao, L, 2019) |
| "Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide." | 1.51 | Acetaminophen Hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2019) |
| "Sterile inflammation is initiated by damage-associated molecular patterns (DAMPs) and a key contributor to acute liver injury (ALI)." | 1.51 | Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation. ( Chen, H; Deng, Z; He, Y; Li, S; Liao, X; Meng, J; Peng, S; Peng, Y; Peng, Z; Qiu, S; Tang, D; Tao, L; Tu, S; Yang, H, 2019) |
| "Acute liver failure is a serious consequence of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and mortality." | 1.51 | The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice. ( DeMorrow, S; Frampton, G; Grant, S; Jefferson, B; McMillin, M; Petrescu, AD; Williams, E, 2019) |
| "Acetaminophen (paracetamol) is a widely used analgesic-antipyretic drug that causes hepatotoxicity at higher than the effective doses." | 1.51 | Marine macro-algae attenuates nephrotoxicity and hepatotoxicity induced by cisplatin and acetaminophen in rats. ( Ehteshamul-Haque, S; Hira, K; Sohail, N; Sultana, V; Tariq, A, 2019) |
| "Acetaminophen (APAP) is a widely used over-the-counter drug for antipyretic and analgesic, but an overdose will induce acute liver injury." | 1.51 | Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway. ( Gong, X; Jiang, R; Kuang, G; Wan, J; Wang, Y; Wu, S; Xiong, L; Xu, F; Yang, S; Zeng, T, 2019) |
| " Plasma samples were collected at 17 hr after dosing (during the manifestation of symptoms) and at one month (after recovery) and were subjected to LC-MS analysis of NAPQI-adducts." | 1.51 | LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash. ( Kubo, T; Lee, SH; Oe, T; Ozawa, M, 2019) |
| "Celastrol posttreatments exerted a significant increase in the glutathione content and a decrease in the malondialdehyde and protein carbonylation levels." | 1.48 | Celastrol ameliorates acetaminophen-induced oxidative stress and cytotoxicity in HepG2 cells. ( Alpertunga, B; Jannuzzi, AT; Kara, M, 2018) |
| "Acetylcysteine (NAC), an effective antidote for paracetamol poisoning, is commonly associated with adverse reactions." | 1.48 | Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. ( Chandru, P; Gunja, N; Lim, JME; McNulty, R, 2018) |
| " In the present study, we aimed to evaluate the adverse event profiles of OTC combination cold remedy based on the components using the Japanese Adverse Drug Event Report (JADER) database." | 1.48 | [Adverse Event Trends Associated with Over-the-counter Combination Cold Remedy: Data Mining of the Japanese Adverse Drug Event Report Database]. ( Fukuda, A; Hasegawa, S; Hatahira, H; Hirade, K; Iguchi, K; Motooka, Y; Naganuma, M; Nakamura, M; Nakao, S; Sasaoka, S; Shimauchi, A; Ueda, N; Umetsu, R, 2018) |
| " In the present study, the dose-response and time-course model in C57/BL6 mice were established by intraperitoneal injection of APAP." | 1.48 | Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice. ( Kou, R; Shen, Z; Song, F; Su, Z; Wang, Y; Xie, K, 2018) |
| "The simvastatin-treated groups were treated with different doses of simvastatin i." | 1.48 | Simvastatin protects against acetaminophen-induced liver injury in mice. ( Cui, R; Feng, Y; Liang, H; Liu, C; Qiu, M; Zhang, J, 2018) |
| "Pyridoxine treatment significantly increased cell viability and decreased leakage of LDH activity against APAP-induced hepatotoxicity in HepG2 cells." | 1.48 | Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury. ( Choi, SM; De, U; Kacew, S; Kim, HS; Kim, MK; Lee, BM; Lim, DS; Lim, SK; Roh, T; Yoon, S, 2018) |
| "Patients with cystic fibrosis are more likely to have glutathione deficiency, and greater susceptibility to liver injury." | 1.48 | Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity. ( Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A, 2018) |
| " Cholestasis was significantly elevated in model mice when pretreatment with routine or high dosage of PRP, but had no effect on normal mice." | 1.48 | Pinelliae Rhizoma Praeparatum Involved in the Regulation of Bile Acids Metabolism in Hepatic Injury. ( Dang, X; Guo, S; Hu, N; Liu, L; Shi, L; Wei, H; Yang, P; Zhang, S; Zhang, Y, 2018) |
| "Diallyl sulfide (DAS) has been shown to prevent xenobiotic (e." | 1.48 | In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication. ( Gong, Y; Kumar, S; Rahman, MA, 2018) |
| "The acetaminophen-mediated increase in NF-κB was significantly reversed by lophirones B and C." | 1.48 | Lophirones B and C halt acetaminophen hepatotoxicity by upregulating redox transcription factor Nrf-2 through Akt, PI3K, and PKC pathways. ( Ajala-Lawal, RA; Ajiboye, TO; Aliyu, NO, 2018) |
| "Post-treatment with fenofibrate significantly inhibits APAP-induced hepatotoxicity, as evidenced by decreased serum ALT and AST levels and hepatic necrosis in liver tissue as well as increased the surviving rate in response to APAP overdose, whereas this protective effect of fenofibrate is largely attenuated in FGF21 KO mice." | 1.48 | FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice. ( Li, Q; Li, X; Pan, X; Pan, Y; Xiong, R; Yang, S; Zhang, S; Zhang, Y; Zheng, J, 2018) |
| "High-throughput screening (HTS) of liver toxicants can bridge the gap in understanding adverse effects of chemicals on humans." | 1.48 | High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells. ( Ehrich, MF; Orbach, SM; Rajagopalan, P, 2018) |
| "Berberine (BBR) is a natural alkaloid derived from traditional medicine Rhizoma Coptidis and possesses various pharmacological properties." | 1.48 | Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice. ( Hua, W; Liu, X; Liu, Y; Wei, Q; Zhao, Z; Zhu, Y, 2018) |
| "Betaine (500 mg/kg) was chosen as the most effective dose to rescue APAP hepatotoxicity in mice." | 1.48 | Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability. ( Kalantari, H; Khodayar, MJ; Khorsandi, L; Rashno, M; Zeidooni, L, 2018) |
| "In the United States, the Acute Liver Failure Study Group (ALFSG) registry lists approximately 11% of cases as of indeterminate etiology (IND-ALF) as determined by the respective local site principal investigator (PI)." | 1.48 | Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality. ( Bass, N; Chiu, C; Ganger, DR; James, L; Larson, AM; Lee, WM; Rakela, J; Reuben, A; Rule, J; Stravitz, RT; Sussman, N, 2018) |
| " Despite being safe at therapeutic doses, acetaminophen overdose is a leading cause of acute liver failure." | 1.48 | Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats. ( Ebada, ME, 2018) |
| "Acetaminophen (APAP) is a worldwide used drug for treating fever and pain." | 1.48 | Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. ( Gao, X; Huo, X; Kong, Y; Liu, K; Liu, Z; Ma, X; Meng, Q; Ning, C; Sun, H; Sun, P; Wang, C, 2018) |
| "Acetaminophen (APAP)-treated wild-type and FXR knockout mice were used to investigate the functional dependence of the effects of the selected DHPs on FXR." | 1.48 | Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs. ( Guo, F; Jin, L; Li, Y; Lu, Y; Wang, Y; Wei, Y; Xu, S; Yao, B; Zheng, W; Zhu, Y, 2018) |
| "Acetaminophen (APAP) is a well-known antipyretic and analgesic drug." | 1.48 | Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway. ( Ding, Y; Huang, W; Ji, L; Li, L; Liu, C; Sun, K; Tumen, B; Wang, S; Zhang, L; Zhang, W, 2018) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that leads to severe hepatotoxicity at excessive doses." | 1.48 | Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation. ( Gu, JG; Tu, MJ; Wang, YQ; Wei, JG; Zhang, W, 2018) |
| " Short-term administration of Schisandrae Chinensis Fructus may inhibit CYP450s activity, while long-term administration may up-regulate CYP activity." | 1.48 | [Effects of Schisandrae Chinensis Fructus induced CYPs and Nrf2 activation on acute liver injury induced by acetaminophen]. ( Feng, S; Liu, K; Qiu, BX; Zhu, HF; Zou, L, 2018) |
| "Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible to sepsis." | 1.46 | Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. ( Abeles, RD; Anderson, AE; Antoniades, CG; Auzinger, G; Bernal, W; Bernsmeier, C; El-Masry, A; Hou, TZ; Khamri, W; Kudo, N; Larsen, FS; Lebosse, F; Lombardi, G; Possamai, LA; Singanayagam, A; Thursz, M; Triantafyllou, E; Wendon, J; Weston, CJ; Willars, C, 2017) |
| "To get the model of acute toxic hepatitis single intraperitoneal injection of paracetamol solution was used (750 mg/kg)." | 1.46 | [EFFECT OF ACETYLCYSTEINE, CORVITIN AND THEIR COMBINATION ON THE FUNCTIONAL STATE OF LIVER IN RATS WITH PARACETAMOL INDUCED TOXIC HEPATITIS]. ( Antelava, N; Ghonghadze, M; Liluashvili, K; Okujava, M; Pachkoria, K, 2017) |
| "Acetaminophen is a common antipyretic drug but at overdose can cause severe hepatotoxicity that may further develop into liver failure and hepatic centrilobular necrosis in experimental animals and humans." | 1.46 | PROTECTIVE EFFECT OF ( Abdelrahem, MT; Azim, SAA; Khattab, A; Said, MM, 2017) |
| "Acetaminophen (APAP) is a common medication that induces hepatocellular damage in a time- or dose-dependent manner." | 1.46 | FGF21 functions as a sensitive biomarker of APAP-treated patients and mice. ( Chen, J; Guo, C; Huang, Z; Li, R; Wu, X, 2017) |
| "Kamebakaurin (KA) is an ent-kaurane diterpenoid known to have anti-inflammatory potential." | 1.46 | Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice. ( Adachi, Y; Aoyagi, Y; Fukuishi, N; Gui, MY; Hitotsuyanagi, Y; Jin, YR; Li, XW; Miura, N; Nonogaki, T; Ohno, N; Takeya, K; Yoshioka, H, 2017) |
| "We performed pharmacokinetic simulations using Berkeley Madonna (version 8." | 1.46 | Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. ( Graudins, A; Landersdorfer, C; Wong, A, 2017) |
| "Treatment with acetaminophen significantly elevated the levels of inflammatory cytokines by hES-HLCs." | 1.46 | Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells. ( Cho, EB; Han, YM; Jang, MJ; Jeong, WI; Kim, DE; Kim, E; Kim, MY; Kim, S; Kim, Y; Kim, YR; Lee, JY; Lee, SH, 2017) |
| "Acetaminophen (APAP) is a widely used antipyretic and analgesic drug, which is safe and effective at the therapeutic dose." | 1.46 | Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice. ( Chen, X; Gong, X; Jiang, R; Kuang, G; Li, K; Ma, L; Tie, H; Wan, J; Wang, B; Xie, T; Yang, G; Zhang, L, 2017) |
| "Acetaminophen (APAP) is a widely available antipyretic and analgesic; however, overdose of the drug inflicts severe damage to the liver." | 1.46 | Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro. ( Hara, A; Kanno, SI; Tomizawa, A; Yomogida, S, 2017) |
| " To investigate this, mice were treated with toxic doses of APAP and euthanized between 0 and 96 h." | 1.46 | Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. ( Asselah, T; Ding, WX; Du, K; Farhood, A; Jaeschke, H; Mansouri, A; McGill, MR; Ramachandran, A; Woolbright, BL, 2017) |
| "Acetaminophen (APAP) is a readily available and safe painkiller." | 1.46 | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. ( Choi, D; Kim, JY; Kim, TH; Koo, SH; Lee, JH, 2017) |
| "Acetaminophen toxicity is a common cause of pediatric liver failure." | 1.46 | Serum Acetaminophen Protein Adduct Concentrations in Pediatric Emergency Department Patients. ( Anderson, V; Dart, RC; Green, JL; Heard, K; Kile, D; Lavonas, EJ, 2017) |
| "Lycopene is a natural compound that was able to inhibit the production of ROS in vitro and mitigate the damage caused by APAP overdose in vivo." | 1.46 | Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL/6 mice. ( Araujo, CM; Bandeira, ACB; Bezerra, FS; Costa, DC; da Silva, RC; da Silva, TP; de Araujo, GR; Lima, WG, 2017) |
| "Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death." | 1.46 | Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. ( Bandeira, ACB; Bezerra, FS; Cangussú, SD; Costa, DC; da Silva, RC; Figueiredo, VP; Rossoni, JV; Talvani, A, 2017) |
| " Our findings indicate that replacing the current APAP with a safe and functional APAP/5'-AMP formulation could prevent APAP-induced hepatotoxicity." | 1.46 | Adenosine 5'-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation. ( Kong, Y; Sun, Q; Xu, X; Yang, X; Zhan, Y; Zhang, J, 2017) |
| "We report here the successful treatment of hepatitis C virus (HCV) transmitted from a nucleic acid testing (NAT)-negative donor to three HCV-negative recipients-two renal transplants and one liver." | 1.46 | Successful treatment of donor-derived hepatitis C viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens. ( Cameron, A; Fenkel, JM; Frank, AM; Shah, AP; Singh, P, 2017) |
| "Baicalin treatment significantly attenuated the elevation of liver ALT levels, as well as hepatic MPO activity in a dose- dependent manner (15-60[Formula: see text]mg/kg) in APAP-treated mice." | 1.46 | ERK Signaling Pathway Plays a Key Role in Baicalin Protection Against Acetaminophen-Induced Liver Injury. ( Chou, AH; Day, YJ; Lee, HC; Liao, CC; Liou, JT; Liu, FC, 2017) |
| " In vitro cytotoxicity assays confirmed that HLCs from patients with clinically identified hepatotoxicity were more sensitive to PZ-induced toxicity than other individuals, while a prototype hepatotoxin acetaminophen was similarly toxic to all HLCs studied." | 1.46 | Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. ( Choudhury, Y; Kanesvaran, R; Li, H; Poh, J; Qu, Y; Tan, HS; Tan, MH; Toh, YC; Xing, J; Yu, H, 2017) |
| "Acetaminophen (APAP) is a conventional drug widely used in the clinic because of its antipyretic-analgesic effects." | 1.46 | Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice. ( Bi, J; Deng, Y; Gu, J; Liu, C; Zhang, J; Zhang, S, 2017) |
| " Finally, the pharmacodynamic mimicry of GSH by ψ-GSH is illustrated through the isolation and chemical characterization of an entity that can arise only through direct encounter of ψ-GSH with N-acetyl-p-benzoquinoneimine, the primary toxic metabolite of APAP." | 1.46 | Hepatoprotective Effect of ψ-Glutathione in a Murine Model of Acetaminophen-Induced Liver Toxicity. ( More, SS; Nugent, J; Nye, SM; Vartak, AP; Vince, R, 2017) |
| " Hepatotoxicity induced by toxic dose of paracetamol was revealed also by notable histopathological alterations, which were not observed in the group treated with paracetamol together with apigenin." | 1.46 | Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. ( Čapo, I; Gigov, S; Kojić-Damjanov, S; Martić, N; Milijašević, B; Paut Kusturica, M; Rašković, A, 2017) |
| " It is established that the degree of paracetamol toxicity and the level of hepatocyte RG are mutually dependent: the higher the content of RG in cells, the less pronounced toxic effect of xenobiotic is and vice versa, which is confirmed by correlation analysis (r = 0." | 1.43 | [CIRCADIAN DEPENDENCE OF PARACETAMOL HEPATOTOXICITY IN RATS.] ( Drogovoz, SM; Kal'ko, KO; Pozdnyakova, AY; Zakharko, NV, 2016) |
| " Our observation suggested that silymarin ameliorated the toxic effects of APAP-induced hepatotoxicity and nephrotoxicity in mice." | 1.43 | Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. ( Baycu, C; Bektur, NE; Sahin, E; Unver, G, 2016) |
| "Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide." | 1.43 | Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. ( Claessen, SM; Coonen, ML; Jetten, MJ; Kleinjans, JC; Lommen, A; Peijnenburg, AA; Ruiz-Aracama, A; van Delft, JH; van Herwijnen, MH, 2016) |
| " Group 2 received only paracetamol (PARA) (administered orally at a dosage of 300 mg/kg)." | 1.43 | The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist. ( Akpinar, E; Bayir, Y; Halici, Z; Karakus, E; Kose, D; Palabiyik, SS; Yayla, M, 2016) |
| "Analyses of outcomes after acute liver failure (ALF) have typically included all ALF patients regardless of whether they were listed for liver transplantation (LT)." | 1.43 | Determinants of outcome among patients with acute liver failure listed for liver transplantation in the United States. ( Durkalski, V; Ellerbe, C; Fontana, RJ; Lee, WM; Reddy, KR; Schilsky, M; Stravitz, RT, 2016) |
| "The goal of this study is to summarize trends in rates of adverse events attributable to acetaminophen use, including hepatotoxicity and mortality." | 1.43 | Trends in rates of acetaminophen-related adverse events in the United States. ( Ding, Y; Iyasu, S; Major, JM; Mehta, H; Pham, TM; Staffa, JA; Trinidad, JP; Wang, C; Willy, ME; Wong, HL; Zhou, EH, 2016) |
| " It is safe at therapeutic doses, but its overdose can result in severe hepatotoxicity, a leading cause of drug-induced acute liver failure in the USA." | 1.43 | N-acetylcysteine amide, a promising antidote for acetaminophen toxicity. ( Ercal, N; Hart, M; Khayyat, A; Tobwala, S, 2016) |
| "Acetaminophen is a commonly used analgesic that can cause severe hepatotoxicity in overdose." | 1.43 | Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. ( Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, AE; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ, 2016) |
| " Because the safe limit of APAP dosing is controversial, our aim was to evaluate the role of the mitochondrial permeability transition (MPT) and JNK in mitochondrial dysfunction after APAP dosing considered nontoxic by criteria of serum alanine aminotransferase (ALT) release and histological necrosis in vivo." | 1.43 | Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. ( Hu, J; Jaeschke, H; Lemasters, JJ; McGill, MR; Ramshesh, VK, 2016) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug." | 1.43 | Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR. ( Kanno, S; Tomizawa, A; Yomogida, S, 2016) |
| "Obesity and nonalcoholic fatty liver disease (NAFLD) can increase susceptibility to hepatotoxicity induced by some xenobiotics including drugs, but the involved mechanisms are poorly understood." | 1.43 | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. ( Bucher, S; Fromenty, B; Gicquel, T; Jaeschke, H; Le Guillou, D; Martinais, S; McGill, MR; Michaut, A; Moreau, C; Morel, I; Robin, MA, 2016) |
| "Acetaminophen was discontinued and IV acetylcysteine was given and continued at the second maintenance dose rate for a second 16-hour infusion, at which time transaminases, INR, ammonia and total bilirubin were all improving." | 1.43 | Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen. ( Anderson, VE; Dart, RC; Green, JL; Heard, KJ; Kovnat, D; Seifert, SA, 2016) |
| " Mice were then dosed orally eight times over 3 days with additional paracetamol (250 mg/kg) or saline, followed by either one or two doses of oral NAC (1200 mg/kg) or saline." | 1.43 | N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. ( Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, AE; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ, 2016) |
| " Standard mechanistic studies in animals for examining the toxic and pathological changes associated with the chemical exposure have often been limited to the single end point or pathways." | 1.43 | Acetaminophen Induced Hepatotoxicity in Wistar Rats--A Proteomic Approach. ( Agastian, P; Al-Dhabi, NA; Baru, R; Choi, KC; Ilavenil, S; Ock Kim, Y; Srigopalram, S; Valan Arasu, M, 2016) |
| "Pretreatment with clofibrate, a peroxisome proliferator-activated receptor alpha (PPARa) agonist, protects mice from acetaminophen (APAP) injury." | 1.43 | Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. ( Chasson, L; Ferreira, DW; Galland, F; Goedken, MJ; Manautou, JE; Naquet, P; Rommelaere, S, 2016) |
| "Allyl methyl disulfide (AMDS) was identified as one of the bioactive components in fresh garlic paste in our previous study." | 1.43 | Protective effect of allyl methyl disulfide on acetaminophen-induced hepatotoxicity in mice. ( Liu, G; Luan, Y; Wang, K; Yang, M; Zhang, F; Zhang, Y; Zhao, Z, 2016) |
| "Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known agent to cause hepatic and renal toxicity at a higher dose." | 1.43 | Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1. ( Adil, M; Bodhankar, SL; Ghosh, P; Kandhare, AD; Raygude, KS; Venkata, S, 2016) |
| " Significantly, both patients had recently had a dose escalation from 'as needed' dosing to 4 g daily, and the medication was being administered by nursing staff." | 1.43 | Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily? ( Ging, P; Mikulich, O; O'Reilly, KM, 2016) |
| " This dose-response relationship between paracetamol concentration and ALI persisted even in patients treated with NAC within 8 h of overdose (nomogram 0-100: 0%, 101-150: 0." | 1.43 | Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. ( Al-Hourani, K; Bateman, DN; Beckwith, HK; Cairney, DG; Dear, JW; Eddleston, M, 2016) |
| "Mice treated with paeonol (25, 50, 100 mg/kg) received 400 mg/kg acetaminophen intraperitoneally (i." | 1.43 | Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice. ( Chen, Y; Deng, Y; Ding, Y; Li, Q; Qian, K; Xu, Y; Zhi, F, 2016) |
| " Due to hepatotoxicity worries, there are no dose-response studies in children." | 1.43 | A Long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies. ( Cirrincione, KN; Crosswell, HE; Deshpande, D; Gumbo, T; Pasipanodya, JG; Ramachandran, G; Sherman, CM; Shuford, S; Srivastava, S; Swaminathan, S, 2016) |
| "Acetaminophen overdose is a leading cause of drug-induced liver failure in the United States." | 1.43 | Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose. ( Andrenyak, DM; Curry, SC; Grey, TC; McGill, LD; Rollins, DE; Thomas, KC; Wilkins, DG, 2016) |
| "A total of 125,505 patients with liver cirrhosis were registered from January 1, 2012 to December 31, 2012." | 1.43 | The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis. ( An, DS; Cho, M; Han, JH; Heo, J; Hong, YM; Lim, W; Woo, HY; Yoon, KT, 2016) |
| "Treatment of acetaminophen (APAP) in overdose can cause a potentially serious and fatal liver injury." | 1.43 | Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation. ( Liang, W; Lv, L; Wang, P; Yuan, K; Zhang, J; Zhang, X, 2016) |
| " C57BL/6N and C57BL/6J mice were dosed with 200 mg/kg APAP and sacrificed at different time points." | 1.43 | Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. ( Bourdi, M; Cahkraborty, M; Davis, JS; Du, K; Duan, L; Jaeschke, H; Weemhoff, J; Woolbright, BL, 2016) |
| " We discovered that variants of the merged mechanism provide plausible quantitative explanations for the considerable variation in 24-hour necrosis scores among 37 genetically diverse mouse strains following a single toxic acetaminophen dose." | 1.43 | Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments. ( Hunt, CA; Kaplowitz, N; Kennedy, RC; Ookhtens, M; Petersen, BK; Ropella, GE; Smith, AK, 2016) |
| "We wondered whether renal failure would affect APAP-CYS elimination half-life and whether continuous venovenous hemodiafiltration (CVVHDF), commonly used in liver failure patients, would remove adducts to lower their serum concentrations." | 1.42 | Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose. ( Bikin, DS; Curry, SC; Gerkin, RD; O'Connor, AD; Padilla-Jones, A; Rollins, DE; Ruha, AM; Slawson, MH; Wilkins, DG, 2015) |
| " No adverse effects were observed for doses of up to 900 mg/kg/d for 14 d." | 1.42 | Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey. ( Barrass, N; Bi, L; Gales, S; Hutchison, M; Lenz, E; Parry, T; Powell, H; Qiao, J; Qin, Q; Ren, J; Thurman, D; Wilson, ID; Yu, H, 2015) |
| "Paracetamol has an extensive first-pass metabolism that highly affects its bioavailability (BA); thus, dose may be repeated several times a day in order to have longer efficacy." | 1.42 | Glucosamine enhances paracetamol bioavailability by reducing its metabolism. ( Al-Jbour, N; Badwan, AA; Ghattas, MA; Matalka, KZ; Qinna, NA; Shubbar, MH, 2015) |
| "Metformin pretreatment protected against APAP toxicity with decreased liver damage, and inhibited APAP-induced prolonged hepatic JNK phosphorylation in WT mice." | 1.42 | Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. ( Choi, DH; Choi, HS; Hwang, JH; Kim, DK; Kim, KS; Kim, YH; Lee, CH; Noh, JR; Tadi, S; Yim, YH, 2015) |
| "Six lignans pretreatment before APAP dosing could prevent the depletions of total liver glutathione (GSH) and mitochondrial GSH caused by APAP." | 1.42 | Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. ( Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H, 2015) |
| "Previous studies in patients with acute liver failure identified acetaminophen (APAP) protein adducts in the serum of 12% and 19% of children and adults, respectively, with acute liver failure of indeterminate etiology." | 1.42 | Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. ( Alonso, EM; James, LP; Squires, RH; Zhang, S, 2015) |
| "CCl4-induced liver fibrosis protects mice against lethal dose of APAP, Possibly by a mechanism involving inhibition of the cytoplasmic translocation of HMGB1." | 1.42 | [Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury]. ( Bai, L; Chen, Y; Duan, Z; Ren, F; Zhang, X; Zheng, S; Zu, K, 2015) |
| "Acetaminophen (APAP) is a widely used analgesic drug that can cause acute liver injury in overdose situations." | 1.42 | Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice. ( Chen, C; Jiang, Z; Melzig, MF; Wang, J; Xie, W; Zhang, X, 2015) |
| "14%) with acute poisoning at toxic doses showed hepatotoxicity signs, 4 (57." | 1.42 | Hepatotoxicity induced by acute and chronic paracetamol overdose in adults. Where do we stand? ( Borobia, AM; Carcas, AJ; Frías, J; García, S; Martín, J; Martínez, AM; Medrano, N; Quintana, M; Ramírez, E; Ruiz, JA; Tong, HY, 2015) |
| "The luteolin-treated group was given APAP and luteolin (0-100 mg/kg/day, 1 or 3 days before APAP administration) suspended in PBS orally." | 1.42 | Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse. ( Liu, C; Liu, S; Miao, R; Pang, Q; Song, S; Tai, M; Wu, Q; Zhang, J, 2015) |
| "Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure." | 1.42 | Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure. ( Alibhai, H; Andreola, F; Baker, LA; Chang, YM; Davies, NA; Jalan, R; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C, 2015) |
| "Chlorogenic acid (CGA) has been reported to prevent acetaminophen (AP)-induced hepatotoxicity when mice were pre-administered orally with CGA for consecutive 7days before AP intoxication in our previous study." | 1.42 | The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation. ( Ji, L; Lu, B; Sheng, Y; Zheng, Z, 2015) |
| "Acetaminophen (paracetamol) is a well-tolerated analgesic and antipyretic drug when used at therapeutic doses." | 1.42 | Alpha-lipoic acid treatment of acetaminophen-induced rat liver damage. ( Mahmoud, AA; Mahmoud, YI; Nassar, G, 2015) |
| " Together with these new biomarkers of hepatotoxicity, a 12-hour acetylcysteine protocol offers clinicians and patients the possibility for better targeting of therapy, fewer adverse effects, a simpler dosing regimen, and shorter hospital stay." | 1.42 | Changing the Management of Paracetamol Poisoning. ( Bateman, DN, 2015) |
| " Thus, toxic oral APAP doses sufficient to cause severe widespread liver damage do not cause significant damage when administered concurrently with equal amounts of NAC, that is, in the NAC-APAP treated animals, hepatic transaminases increase only marginally and liver architecture remains fully intact." | 1.42 | Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity. ( Andrus, JP; Herzenberg, LA; Owumi, SE, 2015) |
| "Morin was observed to inhibit APAP-induced increase in PHLPP2 activity ex vivo as well as its association with cellular target Akt1." | 1.42 | Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3β axis. ( Kakkar, P; Mathur, A; Rizvi, F, 2015) |
| "Acetaminophen is a widespread and commonly used painkiller all over the world." | 1.42 | Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. ( Reddyhoff, D; Regan, S; Ward, J; Webb, S; Williams, D, 2015) |
| "Only galangin pretreatment showed the protective effect of AIKI." | 1.42 | Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice. ( Chien, CC; Chiu, YT; Lin, TH; Liu, CC; Liu, RH; Su, HL; Tsai, MS; Wang, SH, 2015) |
| "Acetaminophen is a commonly used drug that induces serious hepatotoxicity when overdosed, leading to increased levels of serum aminotransferases." | 1.42 | Acetaminophen-induced liver injury: Implications for temporal homeostasis of lipid metabolism and eicosanoid signaling pathway. ( Azghadi, SM; Gruia, AT; Mic, AA; Mic, FA; Nica, DV; Suciu, M, 2015) |
| " Considering its toxic effect and the loss of protection in PHH, BA is not a clinically useful treatment option for APAP overdose patient." | 1.42 | Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. ( Du, K; Jaeschke, H; McGill, MR; Xie, Y, 2015) |
| "Acetaminophen treatment was found to trigger an oxidative stress in liver, leading to an increase of serum marker enzymes." | 1.40 | Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats. ( Ananth, DA; Aseervatham, GS; Christabel, PH; Jeyadevi, R; Sasikumar, JM; Sivasudha, T, 2014) |
| "Acetaminophen (APAP) is a widely used analgesic." | 1.40 | Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. ( Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD, 2014) |
| "Acetaminophen is a leading cause of acute liver failure (ALF)." | 1.40 | Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. ( Court, MH; Greenblatt, DJ; Hazarika, S; Lee, WM; Peter, I; Vasiadi, M, 2014) |
| "Acetaminophen (APAP) is a substance that harms human health by stimulating free radical production." | 1.40 | Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats. ( Aziz, AT; Rehman, H; Saggu, S; Sakeran, MI; Zidan, N, 2014) |
| "Gap junctional intercellular communication (GJIC), by which glutathione (GSH) and inorganic ions are transmitted to neighboring cells, is recognized as being largely involved in toxic processes of chemicals." | 1.40 | Role of connexin 32 in acetaminophen toxicity in a knockout mice model. ( Arakawa, S; Igarashi, I; Kai, K; Maejima, T; Sanbuissho, A; Teranishi, M, 2014) |
| " In vivo evaluation and histopatholgical study of the selected QT SNEDDSs were achieved after administration of paracetamol over dosage to albino rats." | 1.40 | Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity. ( Ahmed, OA; Ahmed, TA; Badr, JM; Badr-Eldin, SM; El-Say, KM; Tawfik, MK, 2014) |
| " In the following study, the relationship of acylcarnitines with other known indicators of APAP toxicity was examined in children receiving low-dose (therapeutic) and high-dose ('overdose' or toxic ingestion) exposure to APAP." | 1.40 | Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children. ( Beger, RD; Bhattacharyya, S; Gill, P; James, LP; Kearns, GL; Letzig, LG; Marshall, JD; Pence, L; Reed, MD; Simpson, PM; Sullivan, JE; Van Den Anker, JN; Yan, K, 2014) |
| "Acetaminophen (APAP) has been used as a probe drug to investigate drug-induced liver injury (DILI)." | 1.40 | Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice. ( Howell, BA; Siler, SQ; Watkins, PB, 2014) |
| "Acetaminophen is a commonly used over-the-counter analgesic and overdose of acetaminophen was the most frequent cause of acute liver failure." | 1.40 | Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity. ( Bai, Y; Wang, J; Wang, KP; Zhang, JZ, 2014) |
| "Acetaminophen Psi Nomogram is a sensitive and specific tool for prediction of hepatotoxicity secondary to acute acetaminophen overdose." | 1.40 | Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose. ( Chomchai, C; Chomchai, S; Lawattanatrakul, N, 2014) |
| "Acetaminophen has a reasonable safety profile when consumed in therapeutic doses." | 1.40 | Protective effect of pioglitazone, a PPARγ agonist against acetaminophen-induced hepatotoxicity in rats. ( Candasamy, M; Chellappan, DK; Dua, K; Gubbiyappa, KS; Gupta, G; Krishna, G, 2014) |
| "Acetaminophen (APAP) is the most commonly reported toxic ingestion in the world." | 1.40 | Protective effect of chitosan treatment against acetaminophen-induced hepatotoxicity. ( Erkasap, N; Karimi, H; Ozcelik, E; Uslu, S, 2014) |
| "Drug-induced hepatotoxicity is a serious adverse effect with high morbidity and mortality rates but substantial individual to individual variation is observed in its severity." | 1.40 | Highly expressed protein kinase A inhibitor α and suppression of protein kinase A may potentiate acetaminophen-induced hepatotoxicity. ( Bae, ON; Cho, SD; Kim, M; Lee, JY; Lim, KM; Yun, JW, 2014) |
| " Next, the hiPSC-Hep, primary cryopreserved human hepatocytes (cryo-hHep) and the hepatic cell lines HepaRG and Huh7 were treated with staurosporine and acetaminophen, and the toxic responses were compared." | 1.40 | Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes. ( Andersson, TB; Brolén, G; Cotgreave, I; Glinghammar, B; Jonebring, A; Li, XQ; Liljevald, M; Sagemark, J; Sjogren, AK, 2014) |
| "Acetaminophen (APAP) pretreatment with a hepatotoxic dose (400 mg/kg) in mice results in resistance to a second, higher dose (600 mg/kg) of APAP (APAP autoprotection)." | 1.40 | Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes. ( Goedken, MJ; Gurevich, I; Hines, RN; Manautou, JE; Rasmussen, T; Rohrer, PR; Rudraiah, S, 2014) |
| " This study explored the dose-response relationship between ingested acetaminophen and hepatotoxicity, the early biochemical and clinical predictors of hepatotoxicity, the impact of early N-acetylcysteine treatment on hepatotoxicity and the incidence of nephrotoxicity." | 1.40 | Early predictors of severe acetaminophen-induced hepatotoxicity in a paediatric population referred to a tertiary paediatric department. ( Andersen, J; Askbo, N; Hedeland, RL; Iskandar, A; Jørgensen, MH, 2014) |
| "Neostigmine treatment led to significant reduction of serum liver enzymes (LDH (47,147 ± 12,726 IU/l vs." | 1.40 | Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse. ( Eisenbach, C; Hoyler, B; Mogler, C; Sandig, C; Steinebrunner, N; Stremmel, W; Vittas, S, 2014) |
| " The aim of the present study was to develop lecithin-based carrier system of silymarin by incorporating phytosomal-liposomal approach to increase its oral bioavailability and to make it target-specific to the liver for enhanced hepatoprotection." | 1.40 | Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells. ( Deshpande, P; Jain, P; Kumar, N; Kutty, NG; Mathew, G; Rai, A; Raj, PV; Rao, CM; Reddy, ND; Udupa, N, 2014) |
| "The bilirubin levels were significantly (p<0." | 1.40 | Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of Lophira lanceolata and intoxicated with paracetamol (acetaminophen). ( Aba, PE; Ozioko, IE; Udem, ND; Udem, SC, 2014) |
| "Curcumin was administered for 7 successive days, while paracetamol was administered at day six of treatment." | 1.40 | Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats. ( Abdo Nassan, M; Ismail, TA; Soliman, MM, 2014) |
| "Acetaminophen (APAP) is a commonly used analgesic and antipyretic." | 1.40 | Protective effect of Baccharis trimera extract on acute hepatic injury in a model of inflammation induced by acetaminophen. ( Brandão, GC; Chaves, MM; Costa, DC; de Souza, GH; Lima, WG; Magalhães, CL; Pádua, Bda C; Pedrosa, ML; Rodrigues, IV; Rossoni Júnior, JV; Silva, ME, 2014) |
| "Acetaminophen (APAP) is a widely used antipyretic and analgesic, but an acute or cumulative overdose of acetaminophen can cause severe hepatic failure." | 1.40 | Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice. ( Bae, H; Chung, HS; Keum, DJ; Kim, H; Kwak, Jw, 2014) |
| "Acetaminophen was co-administered orally to rats for 3 days following 28 days of arsenic pre-exposure (Phase-I) and thereafter, acetaminophen was withdrawn, but arsenic exposure was continued for another 28 days (Phase-II)." | 1.40 | Acetaminophen increases the risk of arsenic-mediated development of hepatic damage in rats by enhancing redox-signaling mechanism. ( Khan, S; Kumar, A; Leo, MD; Majhi, CR; Prawez, S; Sankar, P; Sarkar, SN; Telang, AG, 2014) |
| "In acetaminophen-treated group, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total oxidant status (TOS) in the blood, prothrombin time (PT) and international normalized ratio (INR) were significantly increased when compared with controls." | 1.40 | N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage. ( Baltaci, D; Colakoglu, S; Kandis, H; Kara, IH; Karakus, A; Kaya, H; Memisogullari, R; Saritas, A; Yildirim, U, 2014) |
| " We propose here a strategy based on in vitro tests and QSAR (Quantitative Structure Activity Relationship) models to calibrate a dose-response model predicting hepatotoxicity." | 1.39 | Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: a case study with acetaminophen. ( Brochot, C; Desmots, S; Fioravanzo, E; Mombelli, E; Pavan, M; Péry, AR; Zaldívar, JM; Zeman, FA, 2013) |
| " However, comprehensive dose-response and time course studies have not yet been done." | 1.39 | Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. ( Bajt, ML; Jaeschke, H; Lebofsky, M; McGill, MR; Norris, HR; Rollins, DE; Slawson, MH; Wilkins, DG; Williams, CD; Xie, Y, 2013) |
| "Acetaminophen (APAP) is an antipyretic analgesic drug that when taken in overdose causes depletion of glutathione (GSH) and hepatotoxicity." | 1.39 | Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. ( Alipour, M; Buonocore, C; Omri, A; Pucaj, K; Suntres, ZE; Szabo, M, 2013) |
| " APAP toxicity is initiated by its toxic metabolite NAPQI." | 1.39 | CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. ( Barda, L; Chung, RT; Gonzalez-Rodriguez, A; Iwawaki, T; Mills, M; Mueller, T; Nahmias, Y; Scaiewicz, V; Shibolet, O; Tirosh, B; Uzi, D; Valverde, AM; Xavier, R, 2013) |
| "Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation." | 1.39 | Hepatoprotective and antioxidant effects of saponarin, isolated from Gypsophila trichotoma Wend. on paracetamol-induced liver damage in rats. ( Kondeva-Burdina, M; Krasteva, I; Manov, V; Mitcheva, M; Simeonova, R; Vitcheva, V, 2013) |
| "Acetaminophen intoxication is a leading cause of acute liver failure." | 1.39 | Efficacy of adipose tissue-mesenchymal stem cell transplantation in rats with acetaminophen liver injury. ( Barbagallo, I; Li Volti, G; Piazza, C; Puzzo, L; Salomone, F, 2013) |
| "Acetaminophen (APAP) is a widely used analgesic drug that can cause acute liver injury in overdose situations." | 1.39 | Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice. ( Beger, RD; Greenhaw, J; Lu, Y; Petrova, K; Salminen, WF; Schnackenberg, LK; Sun, J; Yang, X, 2013) |
| "APAP treatments caused necrosis in liver and accompanied by elevated liver PTX-3 levels after 48 h." | 1.39 | Pentraxin 3 as a potential biomarker of acetaminophen-induced liver injury. ( Agilli, M; Akgul, EO; Altinel, O; Aydin, FN; Aydin, I; Bilgi, C; Cakir, E; Cayci, T; Erbil, KM; Ersoz, N; Gulec, M; Isbilir, S; Kurt, YG; Onguru, O; Turker, T; Yaman, H; Yasar, M, 2013) |
| " While the hepatotoxic effects of the drug have been well recognized in cases of acute overdose and chronic supratherapeutic doses, the toxic effects of acetaminophen are rarely documented in cases where therapeutic guidelines are followed." | 1.39 | Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity. ( Boyajian, M; Cheerharan, M; Iorio, ML; Kaufman, SS; Reece-Stremtan, S, 2013) |
| "These results indicated the possible therapeutic action of flower and leaf extract from MO in protecting liver damage in rats given an over dosage of APAP." | 1.39 | Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats. ( Arulselvan, P; Fakurazi, S; Hairuszah, I; Hidayat, MT; Moklas, MA; Sharifudin, SA, 2013) |
| "Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19." | 1.39 | A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013) |
| "Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world." | 1.39 | Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. ( Antoine, DJ; Bateman, DN; Coyle, J; Dear, JW; Goldring, CE; Gray, AJ; Lewis, PS; Masson, M; Moggs, JG; Park, BK; Platt, V; Thanacoody, RH; Webb, DJ, 2013) |
| " was given as toxic dose for inducing hepatotoxicity." | 1.38 | Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. ( Kiran, PM; Raju, AV; Rao, BG, 2012) |
| "Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies." | 1.38 | Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. ( Gardner, CR; Laskin, DL; Laskin, JD; Mishin, V, 2012) |
| "As acetaminophen (APAP) is a well-known hepatotoxin, we investigated the effect of the aqueous extract of the T." | 1.38 | Tournefortia sarmentosa extract attenuates acetaminophen-induced hepatotoxicity. ( Hsu, WH; Huang, HI; Kuo, WH; Lai, YL; Teng, CY; Yang, CC, 2012) |
| "Both delayed presentation and staggered overdose pattern are associated with adverse outcomes following paracetamol overdose." | 1.38 | Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. ( Bates, CM; Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Simpson, KJ, 2012) |
| " A ten-fold IV paracetamol dosing error ocurred, with delayed recognition and treatment resulting in transient hepatotoxicity, with a peak alanine transaminase (ALT) of 1378 IU/L in a 3-year-old child." | 1.38 | Intravenous paracetamol toxicity in a malnourished child. ( Anscombe, M; Berling, I; Isbister, GK, 2012) |
| "Treatment with acetaminophen induced formation of autophagosomes in hepatocytes from wild-type mice, but not in Atg7-deficient mice." | 1.38 | Loss of autophagy promotes murine acetaminophen hepatotoxicity. ( Fukada, H; Igusa, Y; Ikejima, K; Inami, Y; Izumi, K; Komatsu, M; Tanaka, K; Watanabe, S; Yamashina, S, 2012) |
| " In conclusion, we discovered metabolite biomarkers belonging to three different metabolic pathways to check for liver toxicity with mass spectrometry from a metabolomics study that could be used to evaluate hepatotoxicity induced by drugs or other toxic compounds." | 1.38 | Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics. ( Chung, BC; Jung, BH; Kumar, BS; Kwon, OS, 2012) |
| "Acetaminophen-induced acute liver failure (ALF) is a complex multiorgan illness." | 1.38 | Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. ( Agarwal, B; Betrosian, A; Burroughs, AK; Cholongitas, E; O'Beirne, J; Patch, D; Shaw, S; Theocharidou, E; Vasianopoulou, P, 2012) |
| "Coenzyme Q10 treatment was given as two i." | 1.38 | Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. ( Fouad, AA; Jresat, I, 2012) |
| " Microfluidic bioartificial organs enable the spatial and temporal control of cell growth and biochemistry, critical for organ-specific metabolic functions and particularly relevant to testing the metabolic dose-response signatures associated with both pharmaceutical and environmental toxicity." | 1.38 | Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs. ( Baudoin, R; Blaise, BJ; Brochot, C; Defernez, M; Domange, C; Dumas, ME; Leclerc, E; Legallais, C; Navratil, V; Péry, AR; Pontoizeau, C; Prot, JM; Shintu, L; Toulhoat, P, 2012) |
| "Acetaminophen-induced acute liver failure (AALF) is associated with innate immunity activation, which contributes to the severity of hepatic injury and clinical outcome." | 1.38 | Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. ( Abeles, R; Antoniades, CG; Auzinger, G; Barnardo, A; Bernal, W; Bruce, M; Heaton, N; Hussain, M; McPhail, M; Mitry, RR; Pomplun, S; Possamai, LA; Quaglia, A; Starling, C; Taams, LS; Thursz, MR; Vergani, D; Wagner, B; Wendon, J, 2012) |
| "Acetaminophen (paracetamol) plays a vital role in American health care, with in excess of 25 billion doses being used annually as a nonprescription medication." | 1.38 | Confusion: acetaminophen dosing changes based on NO evidence in adults. ( Krenzelok, EP; Royal, MA, 2012) |
| " Additional important factors that may affect drugs' bioavailability and toxicity are gestational age, birth weight, intrauterine growth restriction, gender and, especially, liver function immaturity." | 1.38 | Hepatic injury to the newborn liver due to drugs. ( Ambu, R; Faa, G; Nemolato, S; Van Eyken, P, 2012) |
| " Mkp-1⁺/⁺ and Mkp-1⁻/⁻ mice were dosed ip with vehicle or acetaminophen at 300 mg/kg (for mechanistic studies) or 400 mg/kg (for survival studies)." | 1.38 | Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. ( Liu, Y; Meng, X; Rogers, LK; Wancket, LM, 2012) |
| "2 % made serious errors by dosing out more than six grams." | 1.38 | Risk of unintentional overdose with non-prescription acetaminophen products. ( Bailey, SC; Davis, TC; Di Francesco, L; Jacobson, K; King, J; McCarthy, D; Mullen, R; Parker, RM; Serper, M; Wolf, MS, 2012) |
| "Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters." | 1.38 | Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study. ( Bala, S; Petrasek, J; Szabo, G; Ward, J, 2012) |
| " Data obtained with the prophylactic protocol of treatment might indicate that individuals under treatment with ACE inhibitors are less susceptible to the toxic effects of APAP." | 1.38 | Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice. ( Betto, MR; Campos, MM; Driemeier, D; Lazarotto, LF; Leite, CE; Watanabe, TT, 2012) |
| "Phospholipidosis (PLD), an abnormal accumulation of phospholipids within tissues, is observed during the preclinical testing of many pharmaceutical drugs." | 1.38 | Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats. ( Colatsky, T; Mans, D; Rosenzweig, BA; Shea, K; Stewart, S; Thompson, KL; Zhang, J, 2012) |
| "Telmisartan treatment (two i." | 1.38 | Therapeutic role of telmisartan against acetaminophen hepatotoxicity in mice. ( Al-Mulhim, AS; Fouad, AA; Gomaa, W; Jresat, I, 2012) |
| "Acetaminophen is a widely prescribed drug used to relieve pain and fever; however, it is a leading cause of drug-induced liver injury and a burden on public healthcare." | 1.38 | Identification of early biomarkers during acetaminophen-induced hepatotoxicity by fourier transform infrared microspectroscopy. ( Chandrasekar, B; Deobagkar-Lele, M; Gautam, R; Kumar B N, V; Nandi, D; Rakshit, S; Umapathy, S, 2012) |
| "Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent." | 1.38 | Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients. ( Hashimoto, T; Kobayashi, A; Kondo, K; Kuno, H; Shoda, T; Sugai, S; Suzuki, Y; Takahashi, A; Toyoda, K; Yamada, N, 2012) |
| "Acetaminophen is a commonly used analgesic and has been shown to be a main cause of drug-induced liver failure." | 1.37 | Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose. ( Mehrpour, O; Sanaei-Zadeh, H; Shadnia, S, 2011) |
| " pentaphylla is able to alter the toxic condition of the hepatocytes so as to protect the membrane integrity against paracetamol-induced leakage of marker enzymes." | 1.37 | Hepatoprotective activity of Glycosmis pentaphylla against paracetamol-induced hepatotoxicity in Swiss albino mice. ( Jain, R; Nayak, SS; Sahoo, AK, 2011) |
| " Pharmacokinetic analysis of ICG demonstrated that the total body clearance (Cl(T)) of ICG was significantly decreased and the mean residence time (MRT) was significantly increased in the APAP mice compared to the saline mice." | 1.37 | Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. ( Abdel-Rahman, SM; Brown, A; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Milesi-Hallé, A, 2011) |
| " This down-regulation results in suppression of downstream cytochrome P450 enzymes involved in conversion of APAP to its toxic metabolite." | 1.37 | Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3. ( Cheng, G; Chow, EK; Deng, JC; Ghaffari, AA; Iyer, SS, 2011) |
| "Elicit subject feedback about active ingredient and dosing information on over-the-counter (OTC) acetaminophen and elicit feedback on proposed plain-language text and icons." | 1.37 | Developing consumer-centered, nonprescription drug labeling a study in acetaminophen. ( Bailey, SC; Davis, TC; Di Francesco, L; Hedlund, LA; Jacobson, KL; King, JP; Parker, RM; Wolf, MS, 2011) |
| " No adverse outcomes were associated with medication errors." | 1.37 | Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity. ( Halcomb, SE; Johnson, MT; McCammon, CA; Mullins, ME, 2011) |
| "Acetaminophen treatment increased both the cytosolic and mitochondria-associated P-JNK levels, but the c-jun-N-terminal kinase (JNK) signaling inhibitor SP600125 was hepatoprotective in wildtype mice only, indicating that the JNK pathway may not be critically involved in the absence of CypD." | 1.37 | Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition. ( Boelsterli, UA; LoGuidice, A, 2011) |
| " For studies of toxic processes, 1H NMR spectroscopy of biofluids allows monitoring of endogenous metabolite profiles that alter characteristically in response to changes in physiological status." | 1.37 | A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. ( Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T, 2011) |
| "Hyperammonemia is a major contributing factor to the encephalopathy associated with liver disease." | 1.37 | Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy. ( Brusilow, SW; Cooper, AJ, 2011) |
| " As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind to lysine residues, we investigated whether deacetylation predisposes mice to toxic metabolite-mediated disruption of mitochondrial proteins." | 1.37 | SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity. ( Aponte, AM; Bourdi, M; Chen, Y; Gucek, M; Li, JH; Lombard, DB; Lu, Z; Pohl, LR; Sack, MN, 2011) |
| " Thus, we observed 50% growth inhibition of cell proliferation at 1 mM in the biochip, which appeared similar to human plasmatic toxic concentrations reported at 2 mM." | 1.37 | Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. ( Briffaut, AS; Chafey, P; Grandvalet, Y; Leclerc, E; Legallais, C; Letourneur, F; Merlier, F; Prot, JM, 2011) |
| " Three hundred milligrams per kilogram APAP was chosen because this dosage induces hepatotoxicity but is not lethal." | 1.37 | 3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity. ( Aliaga, C; Amin, S; Isom, HC; Kang, BH; Kocher, S; Krzeminski, J; McDevitt, EI; Moon, MS; Richie, JP; Zhu, J, 2011) |
| " Efforts to curtail this practice may involve provision of prescriber and pharmacist education, utilization of benefit manager systems to flag excessive dosing or that require confirmation of dosing, and implementation of US FDA recommendations supported by these data." | 1.37 | Opioid-paracetamol prescription patterns and liver dysfunction: a retrospective cohort study in a population served by a US health benefits organization. ( Mort, JR; Ndehi, LN; Shiyanbola, OO; Stacy, JN; Xu, Y, 2011) |
| "Treatment with acetaminophen significantly elevated levels of plasma GOT and GPT as well as hepatic TBARS but reduced hepatic GSH levels in CO compared to OO and BT groups." | 1.37 | Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats. ( Chang, YH; Chung, H; Hwang, HJ; Hwang, J; Kim, SY; Park, JH; Shim, E, 2011) |
| " Liver regeneration is a vital process for survival after a toxic insult." | 1.37 | Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity. ( Kajander, H; Koskinen, ML; Tenhunen, J; Yang, R; Zhang, S; Zhu, S, 2011) |
| "The treatment of 6-gingerol and silymarin to acetaminophen-induced hepatotoxicity showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, and ALP) and total bilirubin in serum (P<0." | 1.37 | 6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice. ( Kumar, S; Pragasam, SJ; Rasool, M; Sabina, EP, 2011) |
| " Results show that rats administered with toxic doses (1000 mg/kg, 3000 mg/kg, 5000 mg/kg BW) of paracetamol exhibited significant increases in the levels of ALT, AST, γ- GT compared with controls." | 1.37 | Biochemical and histologic presentations of female Wistar rats administered with different doses of paracetamol/methionine. ( Adeniyi, FA; Iyanda, AA, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Acute renal failure is a recognized manifestation of paracetamol toxicity, but comparatively little data is available concerning its onset and duration." | 1.36 | Delayed onset of acute renal failure after significant paracetamol overdose: A case series. ( Jamie, H; Leggett, GE; Waring, WS, 2010) |
| "Acetaminophen (APAP) is a widely used over the counter therapeutic that is known to be effective and safe at therapeutic doses." | 1.36 | The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. ( Holt, MP; Ju, C; Martin-Murphy, BV, 2010) |
| "Acetaminophen (APAP) is a widely used antipyretic and analgesic agent." | 1.36 | Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat. ( Asamoto, M; Naiki, T; Naiki-Ito, A; Ogawa, K; Sato, S; Shirai, T; Takahashi, S, 2010) |
| " Adoption of these two recommendations may lead to the increased use of NSAIDs with the potential of increasing incidence of NSAIDs-related adverse reactions." | 1.36 | FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable? ( Day, RO; Graham, GG; Graudins, A; Mohamudally, A, 2010) |
| "Acetaminophen is a dose-dependent toxin." | 1.36 | Acetaminophen dose does not predict outcome in acetaminophen-induced acute liver failure. ( Gregory, B; Larson, AM; Lee, WM; Reisch, J, 2010) |
| "Acetaminophen poisoning is a common clinical problem, and early identification of patients with more severe poisoning is key to improving outcomes." | 1.36 | Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010) |
| "Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen." | 1.36 | The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. ( Aralica, G; Blagaić, V; Boban-Blagaić, A; Culo, F; Houra, K; Kelava, T; Konjevoda, P; Kos, M; Stambuk, N; Turcić, P, 2010) |
| " The FDA advisory committee reviewed numerous observational studies and adverse event reporting data." | 1.36 | Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications. ( Dahl, JL; Duh, MS; Korves, C; Michna, E, 2010) |
| "Vomiting was present in 65." | 1.36 | Assessing the impact of vomiting episodes on outcome after acetaminophen poisoning. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010) |
| " Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species." | 1.36 | The effect of acetaminophen nanoparticles on liver toxicity in a rat model. ( Asefnejad, A; Biazar, E; Mahmoudi, M; Mazinani, R; Montazeri, N; Pourshamsian, K; Rahimi, M; Rezayat, SM; Zadehzare, M; Zeinali, R; Ziaei, M, 2010) |
| "Hydroxyproline, which is an indicator of fibrosis in liver tissue, was high in the ethanol-treated control group." | 1.36 | Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage. ( Firdous, AP; Kuttan, R; Preethi, KC; Sindhu, ER, 2010) |
| "Acetaminophen was more toxic to the CD45 dim and negative populations than to the CD45 bright population." | 1.36 | Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. ( DeLeve, LD; Wang, L; Wang, X; Xie, G, 2010) |
| "Acetaminophen treatment significantly elevated both alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities; however, the pre-intake of G." | 1.35 | Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury. ( Hsu, CC; Lin, KY; Lin, WL; Wang, ZH; Yin, MC, 2008) |
| "Acetaminophen (APAP) is safe at therapeutic levels but causes liver injury via N-acetyl-p-benzoquinone imine (NAPQI)-induced oxidative stress when overdose." | 1.35 | Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. ( Chan, EC; New, LS; Tan, SC, 2008) |
| "In patients with massive acetaminophen ingestion, erratic absorption may occur, and toxic serum concentrations may persist beyond a standard 21-hour course of intravenous NAC therapy." | 1.35 | Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. ( Hoffman, RS; Howland, MA; Nelson, LS; Smith, SW, 2008) |
| "Acetaminophen is an OTC medication and amongst the most used pain relievers." | 1.35 | [Accidental acetaminophen overdose]. ( Hamwi, I; Picksak, G; Stichtenoth, DO, 2008) |
| "Acetaminophen (AAP) is a commonly used analgesic and antipyretic drug; however, when used in high doses, it causes fulminant hepatic necrosis in both humans and experimental animals." | 1.35 | Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage. ( Bilgili, A; Eraslan, G; Onbasilar, I; Ozdemir, M; Yalçin, S, 2008) |
| " Appropriate dosing and managing of these drugs do not likely lead to organ toxicity." | 1.35 | Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report. ( Angeli, S; Brugnara, M; Cuzzolin, L; Zaffanello, M, 2009) |
| " A dose-response study showed that the accumulation of long-chain acylcarnitines in serum contributes to the separation of wild-type mice undergoing APAP-induced hepatotoxicity from other mouse groups in a multivariate model." | 1.35 | Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. ( Chen, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Shah, YM, 2009) |
| " Furthermore, the use of antidotes that reduced the toxic insult was also recorded using this technique." | 1.35 | Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. ( Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A, 2009) |
| " Liver regeneration is a vital process for survival after a toxic insult, it occurs at a relative late time point after the injurious phase." | 1.35 | Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity. ( Fink, MP; He, X; Killeen, ME; Miki, K; Yang, R, 2009) |
| "Acetaminophen is a commonly used drug for the treatment of patients with common cold and influenza." | 1.35 | Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. ( Chan, AK; Chan, AS; Cheng, CH; Cheng, GY; Chui, CH; Fong, DW; Gambari, R; Hau, DK; Kan, CW; Kok, SH; Lai, PB; Lau, FY; Leung, AK; Tang, JC; Tong, CS; Wong, RS; Wong, WY; Yuen, MC; Zhu, GY, 2009) |
| "Toxicogenomic studies are increasingly used to uncover potential biomarkers of adverse health events, enrich chemical risk assessment, and to facilitate proper identification and treatment of persons susceptible to toxicity." | 1.35 | Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. ( Gatti, DM; Harrill, AH; Ross, PK; Rusyn, I; Threadgill, DW, 2009) |
| "Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose." | 1.35 | Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. ( Cheng, J; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X, 2009) |
| "Model of acute toxic hepatitis was created using paracetamol (peroral administration with the dose of 1000 mg/kg, once a day)." | 1.35 | [Influence of different type beta-adrenoblockers on functional state of liver at paracetamol induced toxic hepatitis in experiment]. ( Antelava, NA; Arziani, BA; Gabuniia, LIu; Gambashidze, KG; Pkhaladze, NG, 2009) |
| " The histopathological examination on toxic models revealed centrizonal necrosis and fatty changes." | 1.35 | Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. ( Girish, C; Jayanthi, S; Koner, BC; Pradhan, SC; Rajesh, B; Ramachandra Rao, K, 2009) |
| " To better understand the contributions of different signaling pathways, the expression and role of Ras activation was evaluated after oral dosing of mice with APAP (400-500 mg/kg)." | 1.35 | Farnesyltransferase inhibitors reduce Ras activation and ameliorate acetaminophen-induced liver injury in mice. ( Nandi, D; Saha, B, 2009) |
| "Acetaminophen treatment significantly depleted hepatic GSH and ascorbic acid levels, increased hepatic level of malonyldialdehyde (MDA), reactive oxygen species (ROS), and oxidized glutathione (GSSG), as well as decreased hepatic activity of glutathione peroxidase (GPX), catalase, and superoxide dismutase (SOD) (P < 0." | 1.35 | Protective effects from carnosine and histidine on acetaminophen-induced liver injury. ( Chen, HC; Chen, HT; Wu, ST; Yan, SL; Yin, MC, 2009) |
| "Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose." | 1.35 | Acetaminophen toxicity with concomitant use of carbamazepine. ( Ahmed, SN; Heino, A; Jickling, G, 2009) |
| "Iloprost has not shown a similar effect and CAY-10441 increased toxic effect of APAP if given 2 hours after its administration." | 1.35 | The role of prostacyclin in modifying acute hepatotoxicity of acetaminophen in mice. ( Cavar, I; Culo, F; Heinzel, R; Kelava, T, 2009) |
| " Prazosin prevented hepatotoxicity when administered 1 h before a toxic paracetamol insult and importantly, when administered up to 1 h post paracetamol injection." | 1.35 | alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. ( Kitteringham, NR; Macdonald, I; Park, BK; Randle, LE; Sathish, JG; Williams, DP, 2008) |
| " Mice were administered a diet supplemented with GrTP or vehicle for 5 consecutive days followed by intraperitoneal (IP) injection of a toxic dose of APAP or sham." | 1.35 | Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity. ( Chen, TS; Oz, HS, 2008) |
| " The principal component analysis (PCA) of NMR or UPLC/MS spectra showed that metabolic changes observed in both acute and chronic dosing of acetaminophen were similar." | 1.35 | Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. ( Beger, RD; Cantor, GH; Dragan, YP; Holland, RD; Schmitt, TC; Schnackenberg, LK; Sun, J, 2008) |
| " Primary hepatocytes isolated from mice dosed with CFB are resistant to APAP toxicity." | 1.34 | Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. ( Aleksunes, LM; Kardas, MJ; Klaassen, CD; Manautou, JE; Moffit, JS; Slitt, AL, 2007) |
| "3 mug/ml (trough plasma concentration (C(min)) measured just before the next infusion) without any C(max) in the toxic range for any subject." | 1.34 | Safety and pharmacokinetics of paracetamol following intravenous administration of 5 g during the first 24 h with a 2-g starting dose. ( Dufour, G; Evene, E; Gendron, A; Gregoire, N; Gualano, V; Hovsepian, L, 2007) |
| " The sensitivity of the proposed method to detect changes in the NMR spectra 24 and 48 h after single dosing was compared with histopathology and biochemical parameters in plasma and urine." | 1.34 | Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol. ( Horbach, GJ; Kloks, CP; Mellema, JR; Ploemen, JP; Schoonen, WG; Smit, MJ; Tas, AC; van Nesselrooij, JH; Vogels, JT; Zandberg, P; Zuylen, CT, 2007) |
| "Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent." | 1.34 | VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration. ( Bartsocas, CS; Bozas, E; Garyfallidis, S; Grypioti, A; Mykoniatis, MG; Nicolopoulou-Stamati, P; Papastefanou, VP, 2007) |
| "Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or acetaminophen decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities." | 1.34 | Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. ( Jung, YS; Kim, SY; Kim, YC; Park, JH; Yim, HK, 2007) |
| "L-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the beta-oxidation of fatty acid in the mitochondria." | 1.34 | Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. ( Atakisi, O; Citil, M; Erginsoy, S; Karapehlivan, M; Kart, A; Tunca, R; Yapar, K, 2007) |
| "Although used widely and recognized as a safe drug at therapeutic dose, acetaminophen has a narrow therapeutic margin." | 1.34 | [Acetaminophen: hepatotoxicity at therapeutic doses and risk factors]. ( Hadengue, A; Iten, A; Seirafi, M, 2007) |
| "Acetaminophen injury was followed by periportal oval cell accumulation displaying a moderate degree of morphological homogeneity." | 1.33 | Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. ( Hussain, M; Kirschenbaum, A; Kofman, AV; Morgan, G; Osbeck, J; Swenson, S; Theise, ND, 2005) |
| " The administration of a toxic dose of acetaminophen (3." | 1.33 | Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration. ( Basayiannis, AC; Demopoulos, CA; Grypioti, AD; Mykoniatis, MG; Papadimas, GK; Papadopoulou-Daifoti, Z; Theocharis, SE, 2005) |
| " We demonstrate that this non-negative area estimates the cellular burden of toxic adducts formed following overdose." | 1.33 | A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure. ( Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC, 2005) |
| "Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing." | 1.33 | Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. ( Hennig, GE; Manautou, JE; Silva, VM, 2006) |
| " The strongest predictor of severe hepatotoxicity was delayed or no N-acetyl cysteine treatment in patients consuming greater than 10 g of paracetamol or with toxic serum paracetamol levels." | 1.33 | Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience. ( Ayonrinde, OA; Ayonrinde, OT; Hurley, JC; Phelps, GJ, 2005) |
| " The difference in toxic response to APAP between knockout and control strain mice could not be attributed to differences in APAP bioactivation, assessed by measurement of CYP2E1 and glutathione S-transferase activities, hepatic nonprotein sulfhydryl content, or covalent binding of reactive APAP metabolites to proteins." | 1.33 | Increased hepatotoxicity of acetaminophen in Hsp70i knockout mice. ( Dix, DJ; Roberts, SM; Tolson, JK; Voellmy, RW, 2006) |
| " paludosa pretreatment (100-500 mg kg(-1)) in a dose-response manner." | 1.33 | Protective effect of crude extract from Wedelia paludosa (Asteraceae) on the hepatotoxicity induced by paracetamol in mice. ( Bagio, A; Balz, D; Brocardo, PS; Dafre, AL; Goulart, EC; Meotti, FC; Rodrigues, AL; Rosa, JM; Santos, AR; Waltrick, AP, 2006) |
| "Accidental or incidental paracetamol overdose in children may be associated with toxic liver damage leading to fulminant liver failure." | 1.33 | Paracetamol induced hepatotoxicity. ( Davies, P; Kelly, DA; Mahadevan, SB; McKiernan, PJ, 2006) |
| "Severe injury to the liver, such as that induced by toxic doses of acetaminophen, triggers a cascade of events leading to hepatocyte death." | 1.33 | Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice. ( Dun, H; Ekong, U; Emond, JC; Feirt, N; Guarrera, JV; Guo, J; Ippagunta, N; Lu, Y; Qu, W; Ramasamy, R; Schmidt, AM; Weinberg, A; Zeng, S, 2006) |
| "In addition to hepatic dysfunction, renal failure and disseminated intravascular coagulopathy, we should pay attention to various symptoms like in this case when treating for a acetaminophen poisoning." | 1.33 | [Case report of repeated acetaminophen overdosing with various symptoms]. ( Inagawa, H; Ishida, J; Kojima, N; Machida, M; Okada, Y; Terada, T, 2006) |
| " C57BL/6 mice were given an intraperitoneal toxic dose of APAP (500 mg/kg), which caused severe acute liver injury characterized by significant elevation of serum ALT, centrilobular hepatic necrosis, and increased hepatic inflammatory cell accumulation." | 1.33 | Neutrophil depletion protects against murine acetaminophen hepatotoxicity. ( Gunawan, B; Han, D; Kaplowitz, N; Liu, ZX, 2006) |
| "Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-terminal kinase (JNK) inhibitor." | 1.33 | c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. ( Gaarde, WA; Gunawan, BK; Han, D; Hanawa, N; Kaplowitz, N; Liu, ZX, 2006) |
| "Acetaminophen overdose is a frequent cause of acute liver failure." | 1.33 | Severe hepatotoxicity after therapeutic doses of acetaminophen. ( Cairon, E; Mian, P; Moling, O; Pristerá, R; Rimenti, G; Rizza, F, 2006) |
| " The protection afforded by V-PYRRO/NO does not appear to be caused by a decrease in the formation of toxic acetaminophen metabolites, which consumes glutathione (GSH), because V-PYRRO/NO did not alter acetaminophen-induced hepatic GSH depletion." | 1.32 | The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. ( Clark, J; Keefer, LK; Li, C; Liu, J; Myers, P; Saavedra, JE; Waalkes, MP, 2003) |
| " We report a severely malnourished 53-year-old woman who developed severe hepatotoxicity whilst receiving paracetamol at recommended dosage (4 g daily) following a period of fasting, in the absence of enzyme-inducing agents." | 1.32 | Paracetamol-induced hepatotoxicity at recommended dosage. ( Kurtovic, J; Riordan, SM, 2003) |
| " The effect of these drugs was also examined in mice challenged with toxic doses of acetaminophen." | 1.32 | Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. ( Battaglia, G; Freitas, I; Griffini, P; Ngomba, RT; Nicoletti, F; Richelmi, P; Storto, M; Vairetti, M, 2003) |
| " To determine the importance of reversible versus toxic events, N-acetylcysteine (NAC) was administered to mice either before APAP or 1, 2, or 4 h after APAP." | 1.32 | Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. ( Hinson, JA; James, LP; Lamps, LW; McCullough, SS, 2003) |
| "Acetaminophen, a safe analgesic when dosed properly but hepatotoxic at overdoses, has been reported to induce DNA strand breaks but it is unclear whether this event preceeds hepatocyte toxicity or is only obvious in case of overt cytotoxicity." | 1.32 | Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. ( El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E, 2003) |
| " The protection offered by arabic gum does not appear to be caused by a decrease in the formation of toxic acetaminophen metabolites, which consumes glutathione, because arabic gum did not alter acetaminophen-induced hepatic glutathione depletion." | 1.32 | Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice. ( Al-Bekairi, AM; Al-Shabanah, OA; Gamal el-din, AM; Mostafa, AM; Nagi, MN, 2003) |
| " Thereafter, two groups of 15 male Sprague-Dawley rats each were treated with the toxic dose of paracetamol intraperitoneally to induce severe hepatotoxicity." | 1.32 | The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. ( Abraham, AM; Barr, S; Coetsee, C; Walubo, A, 2004) |
| "Acetaminophen (APAP) was selected as a model hepatotoxicant because (1) considerable information exists concerning the mechanism of APAP hepatotoxicity that can occur following high doses, (2) intoxication with APAP is the leading cause of emergency room visits involving acute liver failure within the United States, and (3) conventional clinical markers have poor predictive value." | 1.32 | Gene expression profiling of rat livers reveals indicators of potential adverse effects. ( Blackshear, PE; Boorman, GA; Cunningham, ML; Fannin, RD; Heinloth, AN; Irwin, RD; Li, L; Nettesheim, P; Paules, RS; Sieber, SO; Snell, ML; Tennant, RW; Travlos, GS; Tucker, CJ; Vansant, G, 2004) |
| "Several descriptions of acetaminophen-associated liver injury caused by therapeutic or a dosage slightly above the recommended dosage have been described." | 1.32 | Silent acetaminophen-induced hepatotoxicity in febrile children: does this entity exist? ( Jaffe, M; Maor, I; Novikov, J; Shaoul, R, 2004) |
| "Severe liver injury as a result of overdose or chronic use of acetaminophen (paracetamol) remains a significant clinical problem, accounting for as much as 40% of cases of acute liver failure." | 1.32 | Acetaminophen hepatotoxicity: NO to the rescue. ( Wallace, JL, 2004) |
| "This was a prospective case series of consecutive patients aged 12 years and older with acetaminophen dosage greater than 4 g per 24 hours referred to our poison center." | 1.32 | Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. ( Bogdan, GM; Daly, FF; Dart, RC; Heard, K; O'Malley, GF, 2004) |
| " Another 10 cases represented dosing errors with therapeutic intent (median age, 3." | 1.31 | Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury. ( Alander, SW; Bratton, SL; Dowd, MD; Kearns, GL, 2000) |
| "Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p." | 1.31 | Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats. ( Bhanwra, S; Khosla, P; Singh, J, 2000) |
| "Acetaminophen may increase International Normalized Ratio (INR) in patients taking anticoagulation medication, and in patients with acetaminophen poisoning without hepatic injury." | 1.31 | Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII. ( Buckley, NA; Dawson, AH; Goodhew, I; Reith, DM; Seldon, M; Whyte, IM, 2000) |
| " The high sensitivity of Nrf2-deficient mice was confirmed from observations made at 0, 2, 8, and 24 h after dosing with 300 mg/kg APAP; increased anti-APAP immunoreactivity was also noted in their livers at 2 h." | 1.31 | High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. ( Enomoto, A; Harada, T; Haruta, J; Itoh, K; Kimura, T; Nagayoshi, E; O'Connor, T; Yamamoto, M, 2001) |
| " To investigate this, groups of overnight-fasted male CD-1 mice received 30 micromol ICG/kg, intravenously, immediately prior to APAP dosing (500 mg/kg, ip)." | 1.31 | Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green. ( Chen, C; Hennig, GE; Manautou, JE; Silva, VM; Whiteley, HE, 2001) |
| "Taurine (200 mg/kg) was given 12 h before, at the time of, and 1 or 2 h after acetaminophen injection." | 1.31 | Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. ( Bouchier-Hayes, D; Kay, E; Redmond, HP; Wang, JH; Waters, E; Wu, QD, 2001) |
| "Peak acetaminophen levels were higher in the suicidal overdose group (mean 121." | 1.31 | Acetaminophen toxicity: suicidal vs. accidental. ( Gyamlani, GG; Parikh, CR, 2002) |
| " We studied the effects of TRZ on the hepatotoxicity of carbon tetrachloride (CCl(4)) and acetaminophen (APAP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 3A (CYP3A) and 2E1 (CYP2E1)." | 1.31 | Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats. ( Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y, 2002) |
| " Twenty-eight patients (39%) had severe liver toxic effects, and six of them underwent liver transplantation." | 1.30 | Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity. ( Ament, ME; Berquist, W; Davis, J; Gugig, R; Heyman, MB; McDiarmid, S; Rivera-Penera, T; Rosenthal, P; Vargas, J, 1997) |
| " The results of these studies demonstrated that CS-mediated protection is not selective for a particular species, organ system or toxic chemical." | 1.30 | Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. ( Fariss, MW; Lippman, HR; Mumaw, VR; Ray, SD, 1997) |
| "A higher frequency of chronic alcohol abuse among the patients with accidental overdoses may be one explanation." | 1.30 | Acetaminophen toxicity in an urban county hospital. ( Casey, DL; Lee, WM; Rochling, FA; Schiødt, FV, 1997) |
| "Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90)." | 1.30 | Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction. ( Roberts, SM; Salminen, WF; Voellmy, R, 1997) |
| " The prodrugs were designed to release L-cysteine, which is then available to support glutathione (GSH) biosynthesis and provide cytoprotection against a variety of toxic insults." | 1.30 | Differential chemoprotection against acetaminophen-induced hepatotoxicity by latentiated L-cysteines. ( Franklin, MR; Lamb, JG; Phaneuf, HL; Roberts, JC; Szakacs, JG; Zera, RT, 1998) |
| " The risk factors for the development of liver cell necrosis following ingestion of paracetamol in therapeutic dosage are discussed." | 1.30 | [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage]. ( Krähenbühl, S; Kronenberg, A; Streuli, R; Zimmermann, A, 1998) |
| " We studied the effects of acarbose on the hepatotoxicity of carbon tetrachloride (CCl4) and acetaminophen (AP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 2E1 (CYP2E1)." | 1.30 | Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. ( Kaneko, T; Sato, A; Wang, PY; Wang, Y, 1999) |
| "The significance of the action of DDB on alcoholic fatty liver generation in clinical settings is discussed." | 1.30 | Effect of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'- dicarboxylate (DDB) on chemical-induced liver injury. ( Ham, KS; Kim, SK; Kim, SN; Kim, SY; Kim, YC; Lee, WY; Yim, HK; Yoon, MY, 1999) |
| "Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 1.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
| " We have developed a mouse model to demonstrate the toxic effects of methotrexate: mice were given 50 mg/kg acetaminophen, which itself has no effect on the liver." | 1.30 | Nicotinamide and methionine reduce the liver toxic effect of methotrexate. ( Bache, K; Hauschild, A; Kröger, H; Krüger, D; Ohde, M; Thefeldt, W; Voigt, WP, 1999) |
| " These results suggest that ethanol inhibited not only the microsomal (CYP2E1 mediated) formation of a toxic quinone metabolite from APAP, but also accelerated the conversion of the toxic quinone metabolite produced back to APAP by stimulating cytoplasmic QR activity." | 1.30 | Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase. ( Cha, YN; Cho, TS; Kim, DJ; Lee, SM, 1999) |
| "Acetaminophen was administered at a dose of 650 mg/kg body weight (intraperitoneally) to fasted male Long Evans rats." | 1.29 | Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol. ( Andrews, FJ; Lim, SP; O'Brien, PE, 1995) |
| "Acetaminophen was discontinued and serum transaminase levels returned to baseline levels two weeks later (AST = 26, ALT = 20)." | 1.29 | Abnormal serum transaminases following therapeutic doses of acetaminophen in the absence of known risk factors. ( Bartle, WR; Kwan, D; Walker, SE, 1995) |
| " stocksianum did not produce any lethality or adverse effects in the livers of treated mice." | 1.29 | Effect of Teucrium stocksianum on paracetamol-induced hepatotoxicity in mice. ( Ali, BH; Bashir, AK; Rasheed, RA, 1995) |
| " PSP did not reverse the depletion of total glutathione (GSH+GSSG) by the toxic dose of paracetamol." | 1.29 | Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity in the rat. ( Chiu, LC; Ooi, VE; Yeung, JH, 1994) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that causes massive centrilobular hepatic necrosis at high doses, leading to death." | 1.29 | Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality. ( Bucci, TJ; Chanda, S; Mangipudy, RS; Mehendale, HM; Warbritton, A, 1995) |
| "Andrographolide was found to be more potent than silymarin, a standard hepatoprotective agent." | 1.29 | Andrographolide protects rat hepatocytes against paracetamol-induced damage. ( Dhawan, BN; Patnaik, GK; Shukla, B; Visen, PK, 1993) |
| "Prednisolone pretreatment resulted in decreased covalent binding of the toxic metabolite in vivo and an increased urinary excretion of glutathione-derived conjugates of acetaminophen, indicating an enhanced detoxification of the reactive metabolite by glutathione." | 1.29 | Prednisolone stimulates hepatic glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo. ( Lauterburg, BH; Schranz, C; Speck, RF, 1993) |
| "Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice." | 1.29 | Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993) |
| "Oleanolic acid (OA) is a triterpenoid compound that has been shown to protect against a number of hepatotoxicants, and is used in China to treat hepatitis." | 1.29 | Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice. ( Klaassen, CD; Liu, J; Liu, Y; Madhu, C, 1993) |
| " In the initial 3-week dose-response study, as the daily dose of VA increased so did the degree of potentiation of CCl4 hepatotoxicity." | 1.29 | Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. ( Earnest, DL; elSisi, AE; Hall, P; Sim, WL; Sipes, IG, 1993) |
| "When acetaminophen (250 mg/kg) was injected intraperitoneally in B6C3F1 mice, the plasma GPT activity was significantly increased by 93 or 107-fold at 6 h or 24 h after the drug injection." | 1.29 | Inhibitory effect of cold stress against acetaminophen-induced hepatic injury in B6C3F1 and ICR mice. ( Fujii, K; Hayakawa, T; Yamamoto, H, 1995) |
| " While AAP caused a 117-fold elevation of serum transaminase activities in mice kept on a standard laboratory diet, which was significantly exacerbated by ethanol and inhibited by nicotinic acid amide (NAA), adverse effects were noted in animals fed a diet free of precursors of NAD." | 1.29 | Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice. ( Altrichter, S; Dietrich, A; Ehrlich, W; Grätz, R; Klewer, M; Kröger, H; Kurpisz, M; Miesel, R, 1996) |
| "Research into the pathogenesis of acetaminophen (paracetamol)-induced hepatotoxicity has concentrated on the generation of toxic metabolites by the hepatocytes." | 1.29 | Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity. ( Breach, CS; Brown, IN; Goldin, RD; Ratnayaka, ID; Wickramasinghe, SN, 1996) |
| " One of the mechanisms for this protection appears to be the decreased AA toxic activation via P-450, as well as increased detoxication via glucuronidation of AA." | 1.28 | Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity. ( Jia, XS; Klaassen, CD; Liu, J; Liu, YP; Madhu, C; Mao, Q, 1992) |
| " Fifty-five patients (18%) had toxic paracetamol levels, 51% received treatment with NAC, including 40% of those with non-toxic levels, and 11% of those treated with NAC experienced side effects." | 1.28 | Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge. ( Batey, RG; Brotodihardjo, AE; Byth, K; Farrell, GC, 1992) |
| "0 mmol/kg) alone were toxic to mice induced with benzo(a)pyrene but not to control or phenobarbitone-induced mice." | 1.28 | Cysteine isopropylester protects against paracetamol-induced toxicity. ( Butterworth, M; Cohen, GM; Smith, LL; Upshall, DG, 1992) |
| " A dose-response study showed increased protection with increased intraperitoneal doses of RibCys ranging from 0." | 1.28 | Protection against acetaminophen hepatotoxicity by ribose-cysteine (RibCys). ( Charyulu, RL; Nagasawa, HT; Roberts, JC; Zera, RT, 1992) |
| " Additionally, due to malnutrition and/or to human immunodeficiency virus infection per se, our patient may have had decreased hepatic reserves of glutathione with which to conjugate the toxic acetaminophen product of the P450 system." | 1.28 | Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine. ( Goetz, MB; Shriner, K, 1992) |
| "Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 micrograms/ml for 20 hr." | 1.28 | An improved model of acetaminophen-induced fulminant hepatic failure in dogs. ( Chong, MG; He, DE; Kelly, JH; Koussayer, T; Shang, TA; Sussman, NL; Whisennand, HH, 1992) |
| " The basic mechanism through which PEX reduces the liver toxicity of AAP is assumed to be the decrease in the amount of toxic metabolite formed." | 1.28 | Effect of potassium ethylxanthogenate on the acetaminophen hepatotoxicity in mice. ( Dimova, S; Stoytchev, T, 1990) |
| "Acetaminophen bioactivation was quantified by production of the glutathione-derived cysteine and mercapturic acid conjugates of acetaminophen." | 1.28 | Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid. ( Kalabis, GM; Wells, PG, 1990) |
| " Ranitidine reduced the expected acetaminophen-induced hepatoxicity in a dose-response manner." | 1.28 | Effect of ranitidine on acetaminophen-induced hepatotoxicity in dogs. ( Barone, M; Bell, S; Demetris, J; Guglielmi, FW; Makowka, L; Panella, C; Polimeno, L; Prelich, JG; Rizzi, S; Van Thiel, DH, 1990) |
| "The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
| " The dosage schedule for intravenous N-acetylcysteine should probably be modified since adverse reactions invariably occur early when plasma concentrations are at their highest, and liver damage was prevented just as effectively at the lowest as at the highest Cmax." | 1.28 | The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. ( Donovan, JW; Jarvie, DR; Prescott, LF; Proudfoot, AT, 1989) |
| " Analysis of the actually reported and the computer-assisted predicted data has shown that the computer-assisted predictive formula may be clinically helpful in determining if the plasma acetaminophen level is in the toxic or nontoxic range." | 1.28 | Computer-assisted predictive mathematical relationship among plasma acetaminophen concentration and time and hepatotoxicity in man. ( Chung, SJ, 1989) |
| "142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals." | 1.28 | In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity. ( Delaforge, M; Jaouen, M; Jollès, P; Mansuy, D; Migliore-Samour, D, 1989) |
| " Since the normal human dosage of paracetamol is up to 4 g/day, which is equivalent to 1% of the diet, the possibility of induction of amino acid deficiency by chronic use of paracetamol in normal dosage is raised." | 1.28 | Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats. ( Armstrong, GR; Beales, D; McLean, AE, 1989) |
| "Cimetidine pretreatment also significantly reduced the rate of hepatic glutathione depletion." | 1.27 | Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man. ( Mitchell, MC; Schenker, S; Speeg, KV, 1984) |
| " Measurement by radioimmunoassay of plasma levonorgestrel has been used to compare the pharmacokinetic parameters of the drug after oral and intravenous administration in both control and liver-affected animals." | 1.27 | Influence of acetaminophen-induced hepatic necrosis on the pharmacokinetics of levonorgestrel. ( Gommaa, AA; Osman, FH, 1983) |
| " The development of type B lactic acidosis with hypoglycemia might have been caused by a deficit in gluconeogenesis secondary to severe hepatic failure and/or a toxic metabolite of acetaminophen." | 1.27 | Anion gap acidosis with hypoglycemia in acetaminophen toxicity. ( Schnurr, LP; Zabrodski, RM, 1984) |
| " A comparison of the dose-response curves for hepatic glycogen depletion and glutathione depletion showed that acetaminophen (50-500 mg/kg at 2." | 1.27 | Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice. ( Cameron, AM; Hinson, JA; Mays, JB, 1983) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| " While the glutathione conjugating system is enhanced by selenium treatment, amelioration of acetaminophen toxicity is most likely the result of enhanced glucuronidation which effectively diverts the amount of acetaminophen to be converted by the cytochrome P-450 system to the toxic metabolite." | 1.27 | Protective effects of selenium on acetaminophen-induced hepatotoxicity in the rat. ( Davies, MH; Merrick, BA; Park, KS; Schnell, RC; Weir, SW, 1988) |
| "The effects of acetaminophen and its major toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), have been investigated in hepatocytes isolated from 3-methylcholanthrene-pretreated and -untreated rats, respectively." | 1.27 | The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. ( Moldéus, P; Moore, G; Moore, M; Nelson, S; Orrenius, S; Thor, H, 1985) |
| "Acetaminophen treatment resulted in a twofold increase in macrophage yields from the liver compared with controls." | 1.27 | Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. ( Laskin, DL; Pilaro, AM, 1986) |
| " The same dosage of zinc was not hepatoprotective when given 1 hr after acetaminophen." | 1.27 | Protection by zinc against acetaminophen induced hepatotoxicity in mice. ( Chengelis, CP; Dodd, DC; Kotsonis, FN; Means, JR, 1986) |
| " A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found." | 1.27 | [Paracetamol poisoning in a swine model]. ( Artwohl, J; Dziwisch, L; Henne-Bruns, D; Kremer, B, 1988) |
| " This could be due to an increased activation of the drug to a toxic metabolite or to a decreased capacity to detoxify the toxic metabolite by conjugation with glutathione (GSH)." | 1.27 | Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. ( Lauterburg, BH; Velez, ME, 1988) |
| " A close correlation between administered dosage of the drug, acetaminophen blood levels, and methemoglobinemia was found." | 1.27 | Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models. ( Artwohl, J; Broelsch, C; Henne-Bruns, D; Kremer, B, 1988) |
| "To evaluate the degree of toxicity to the liver of chronic administration of acetaminophen, the slides from two independent previously reported experiments using different strains of mouse were reviewed and compared." | 1.27 | Hepatotoxicity of chronic high dose administration of acetaminophen to mice. A critical review and implications for hazard assessment. ( Maruyama, H; Williams, GM, 1988) |
| " Fatalities in children from a single overdose of acetaminophen have been rare, and there is only one previous report of a fatality after long-term administration of multiple excessive doses." | 1.27 | Death of a child associated with multiple overdoses of acetaminophen. ( Bailey, D; Blake, KV; Hendeles, L; Zientek, GM, 1988) |
| "The effect of dosing paracetamol, 4." | 1.27 | Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. ( Poulsen, HE; Thomsen, P, 1988) |
| "A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented." | 1.27 | Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure. ( Fassett, R; Kritharides, L; Singh, B, 1988) |
| "Disulfiram pretreatment reduced 24 hour urinary excretion of acetaminophen-mercapturate and- cysteine while excretion of -sulfate and -glucuronide was unchanged." | 1.27 | Disulfiram prevents acetaminophen hepatotoxicity in rats. ( Jørgensen, L; Poulsen, HE; Thomsen, P, 1988) |
| " This allowed potentially toxic elevations in calcium concentration to be detected as early as 2 hr after acetaminophen overdose." | 1.27 | Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice. ( Corcoran, GB; Neese, BL; Wong, BK, 1987) |
| " It is a process of limited capacity; the extent of sulfate conjugate formation and the metabolic clearance of drugs subject to conjugation with sulfate depend therefore on the dose, the dosage form, the route of administration, and the rate and duration of administration as well as on the pharmacokinetic parameters of competing processes." | 1.27 | Sulfate conjugation in drug metabolism: role of inorganic sulfate. ( Levy, G, 1986) |
| " Also, the effect of food deprivation of both the euthyroid and PTU-induced hypothyroid rats for 24 h, as well as forced feeding of the euthyroid rats after a toxic dose of APAP, was determined." | 1.27 | Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat. ( Cho, CD; Hirose, N; Raheja, KL, 1987) |
| " The operative status of the hepatic GSH conjugative system has an important influence on the rate of elimination of toxic APAP doses." | 1.27 | Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. ( Ingebrigtsen, K; Jansen, JH; Nafstad, I; Skoglund, LA, 1987) |
| "Since all these patients were alcohol abusers, and the reported paracetamol intake was not remarkably high, it seems reasonable to recommend that paracetamol should be prescribed with great caution to alcoholics, and absolutely not for continuous use." | 1.27 | Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney. ( Denison, H; Kaczynski, J; Wallerstedt, S, 1987) |
| "Acetaminophen (Tylenol) is a widely used analgesic/antipyretic drug which is enzymatically bioactivated, or toxified, by the cytochromes P-450 to a hepatotoxic reactive intermediary metabolite." | 1.27 | Delayed enhancement of acetaminophen hepatotoxicity by general anesthesia using diethyl ether or halothane. ( Ku, MS; Ramji, P; Wells, PG, 1986) |
| "Acetaminophen is a popular analgesic and antipyretic medication that has few side effects and little toxicity when used in recommended doses." | 1.27 | Management of acute acetaminophen overdose. ( Hall, AH; Rumack, BH, 1986) |
| " Since the major nontoxic pathway (glucuronide) and the toxic pathway (as measured by mercapturate) decreased to a similar extent, the data indicate that the anomalous lack of protection cannot be explained on the basis of altered metabolic disposition of the drug." | 1.27 | Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity. ( Jollow, DJ; Miller, MG; Price, VF, 1986) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 1.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| "Pretreatment with phenobarbital (0." | 1.27 | Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats. ( Loeser, W; Siegers, CP, 1985) |
| "Signs of grade 3 hepatic encephalopathy were never found until 72 hours after the overdose, and sudden deterioration in consciousness at an earlier stage was due either to the sedative effects of drugs or to hypoglycaemia, which in one patient went unrecognised for 24 hours." | 1.26 | Factors contributing to mortality in paracetamol-induced hepatic failure. ( Canalese, J; Davis, M; Gimson, AE; Williams, R, 1981) |
| " The rate of formation of acetaminophen sulfate was also modestly increased in diabetic animals, whereas the apparent rate of the toxic pathway was approximately equal in both normal and diabetic animals." | 1.26 | Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity. ( Jollow, DJ; Price, VF, 1982) |
| " To be effective, antidotal therapy must be given early after acetaminophen ingestion when the patient, despite the toxic injury occurring in his liver, may appear quite well." | 1.26 | Liver toxicity after acetaminophen ingestion. Inadequacy of the dose estimate as an index of risk. ( Alexander, M; Ambre, J, 1977) |
| "Acetaminophen is a readily available, widely used drug which has been thought safer than aspirin." | 1.26 | Acute acetaminophen intoxication. ( Austin, F; Carloss, H; Forrester, J; Fuson, T, 1978) |
| "Acetaminophen is a safe drug when used properly, but overdosage can cause severe toxicity." | 1.26 | Acetaminophen poisoning. ( Calvert, LJ; Linder, CW, 1978) |
| " The hallmark of severe (grade III) damage is centrizonal necrosis, for which there is probably a dosage threshold." | 1.26 | Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings. ( Douglas, AP; Hamlyn, AN; James, OF; Lesna, M; Watson, AJ, 1976) |
| "We describe three cases of toxic hepatitis associated with the chronic ingestion of excessive doses of acetaminophen." | 1.26 | Chronic excessive acetaminophen use and liver damage. ( Anuras, S; Barker, JD; de Carle, DJ, 1977) |
| " The plasma half-life of the unchanged drug was significantly prolonged, and the ratio of the plasma concentrations of unchanged to conjugated paracetamol was significantly higher than in the patients without liver damage." | 1.25 | The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. ( Prescott, LF; Wright, N, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 485 (16.10) | 18.7374 |
| 1990's | 267 (8.86) | 18.2507 |
| 2000's | 447 (14.84) | 29.6817 |
| 2010's | 1248 (41.43) | 24.3611 |
| 2020's | 565 (18.76) | 2.80 |
| Authors | Studies |
|---|---|
| Harvison, PJ | 1 |
| Forte, AJ | 2 |
| Nelson, SD | 10 |
| Nagasawa, HT | 6 |
| Goon, DJ | 1 |
| Zera, RT | 4 |
| Yuzon, DL | 1 |
| Fernando, CR | 1 |
| Calder, IC | 4 |
| Ham, KN | 2 |
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 3 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 3 |
| Liu, Z | 11 |
| Shi, Q | 8 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 3 |
| Tong, W | 5 |
| Sakatis, MZ | 1 |
| Reese, MJ | 2 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 9 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 11 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 33 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 5 |
| Suzuki, A | 4 |
| Thakkar, S | 1 |
| Yu, K | 2 |
| Hu, C | 10 |
| Das, M | 3 |
| Bhattacharjee, S | 3 |
| Fronczek, FR | 1 |
| Bazan, NG | 2 |
| Trudell, ML | 1 |
| Bazan, HA | 1 |
| Burgos, C | 1 |
| Recio, J | 1 |
| Abet, V | 1 |
| Pahng, AR | 1 |
| Jun, B | 1 |
| Heap, J | 1 |
| Ledet, AJ | 1 |
| Gordon, WC | 1 |
| Edwards, S | 1 |
| Paul, D | 1 |
| Alvarez-Builla, J | 1 |
| Yan, M | 4 |
| Zhao, C | 3 |
| Lu, S | 3 |
| Cui, J | 2 |
| Sun, Z | 4 |
| Liu, X | 15 |
| Liu, S | 6 |
| Huo, Y | 4 |
| Yin, S | 5 |
| Hu, H | 5 |
| Kitahara, M | 1 |
| Sakamoto, H | 1 |
| Kimura, R | 1 |
| Ikoma-Seki, K | 1 |
| Schmidt, JC | 1 |
| Dougherty, BV | 1 |
| Beger, RD | 10 |
| Jones, DP | 1 |
| Schmidt, MA | 1 |
| Mattes, WB | 2 |
| Li, G | 6 |
| Liu, H | 3 |
| Feng, R | 2 |
| Kang, TS | 1 |
| Wang, W | 9 |
| Ko, CN | 1 |
| Wong, CY | 1 |
| Ye, M | 4 |
| Ma, DL | 1 |
| Wan, JB | 2 |
| Leung, CH | 1 |
| Marques, PE | 5 |
| Vandendriessche, S | 1 |
| de Oliveira, THC | 1 |
| Crijns, H | 1 |
| Lopes, ME | 2 |
| Blanter, M | 1 |
| Schuermans, S | 1 |
| Poosti, F | 1 |
| Vanheule, V | 1 |
| Janssens, R | 1 |
| Boff, D | 1 |
| Kungl, AJ | 1 |
| Menezes, GB | 6 |
| Teixeira, MM | 4 |
| Proost, P | 1 |
| Li, HY | 1 |
| Tang, ZM | 1 |
| Wang, Z | 28 |
| Lv, JM | 1 |
| Liu, XL | 2 |
| Liang, YL | 1 |
| Cheng, B | 1 |
| Gao, N | 1 |
| Ji, SR | 1 |
| Wu, Y | 7 |
| Tan, YL | 2 |
| Nga, ME | 1 |
| Ho, HK | 3 |
| Poudel, S | 2 |
| Cabrera, DP | 1 |
| Bhushan, B | 12 |
| Manley, MW | 2 |
| Gunewardena, S | 3 |
| Jaeschke, H | 141 |
| Apte, U | 16 |
| Hey, P | 1 |
| Gow, P | 1 |
| Yao, F | 1 |
| Wang, X | 18 |
| Cao, X | 2 |
| Zhang, K | 4 |
| Sun, J | 17 |
| Li, Y | 38 |
| Sui, J | 1 |
| Liu, Y | 27 |
| Zhong, X | 1 |
| Zhang, Z | 16 |
| Shen, H | 2 |
| Xiong, Y | 1 |
| Shah, YM | 3 |
| Fan, XG | 1 |
| Rui, L | 2 |
| Khan, A | 6 |
| Gul, R | 1 |
| Rehman, NU | 2 |
| Khan, H | 5 |
| Karim, N | 1 |
| Halim, SA | 2 |
| Ahmed, S | 1 |
| Al-Harrasi, A | 2 |
| Saleh, NEH | 1 |
| Saad, AH | 1 |
| Elbassuoni, EA | 1 |
| El-Tahawy, NF | 1 |
| Abdel-Hakeem, EA | 1 |
| Lewis, JC | 1 |
| Lim, M | 1 |
| Lai, L | 2 |
| Mendoza, E | 1 |
| Albertson, TE | 1 |
| Chenoweth, JA | 1 |
| Nishimura, F | 1 |
| Ushijima, T | 1 |
| Nojima, M | 1 |
| Hamada, S | 1 |
| Hara, K | 1 |
| Hamada, Y | 1 |
| Kadowaki, D | 2 |
| Miyamura, S | 1 |
| Oniki, K | 1 |
| Saruwatari, J | 1 |
| Callegaro, G | 1 |
| Kunnen, SJ | 2 |
| Trairatphisan, P | 1 |
| Grosdidier, S | 1 |
| Niemeijer, M | 1 |
| den Hollander, W | 1 |
| Guney, E | 1 |
| Piñero Gonzalez, J | 1 |
| Furlong, L | 1 |
| Webster, YW | 1 |
| Saez-Rodriguez, J | 1 |
| Sutherland, JJ | 1 |
| Mollon, J | 1 |
| Stevens, JL | 2 |
| van de Water, B | 1 |
| Zhou, Y | 8 |
| Wang, C | 10 |
| Kou, J | 1 |
| Wang, M | 13 |
| Rong, X | 1 |
| Pu, X | 1 |
| Xie, X | 2 |
| Han, G | 1 |
| Pang, X | 1 |
| Stülb, H | 1 |
| Bachmann, M | 3 |
| Gonther, S | 1 |
| Mühl, H | 3 |
| Mehrpour, O | 4 |
| Saeedi, F | 1 |
| Hoyte, C | 2 |
| Ahmed, AMA | 1 |
| Rahman, MA | 2 |
| Hossen, MA | 1 |
| Reza, ASMA | 1 |
| Islam, MS | 2 |
| Rashid, MM | 1 |
| Rafi, MKJ | 1 |
| Siddiqui, MTA | 1 |
| Al-Noman, A | 1 |
| Uddin, MN | 1 |
| Chen, S | 8 |
| Tang, Y | 6 |
| Fang, W | 2 |
| He, T | 1 |
| Chen, X | 25 |
| Zhang, P | 3 |
| Pailleux, F | 1 |
| Maes, P | 2 |
| Jaquinod, M | 1 |
| Barthelon, J | 1 |
| Darnaud, M | 2 |
| Lacoste, C | 1 |
| Vandenbrouck, Y | 1 |
| Gilquin, B | 1 |
| Louwagie, M | 1 |
| Hesse, AM | 1 |
| Kraut, A | 1 |
| Garin, J | 1 |
| Leroy, V | 1 |
| Zarski, JP | 1 |
| Bruley, C | 1 |
| Couté, Y | 1 |
| Samuel, D | 3 |
| Ichai, P | 2 |
| Faivre, J | 2 |
| Brun, V | 1 |
| Link, SL | 1 |
| Rampon, G | 1 |
| Osmon, S | 1 |
| Scalzo, AJ | 1 |
| Rumack, BH | 26 |
| Ahmad, S | 5 |
| Zeb, A | 2 |
| Khan, S | 3 |
| Hong, MK | 1 |
| Liu, HH | 2 |
| Chen, GH | 1 |
| Zhu, JQ | 1 |
| Zheng, SY | 1 |
| Zhao, D | 1 |
| Diao, J | 1 |
| Jia, H | 2 |
| Zhang, DD | 1 |
| Chen, SX | 1 |
| Gao, L | 4 |
| Li, J | 33 |
| Nguyen, NT | 10 |
| Umbaugh, DS | 9 |
| Sanchez-Guerrero, G | 3 |
| Ramachandran, A | 53 |
| Sherlock, LG | 1 |
| Balasubramaniyan, D | 1 |
| Zheng, L | 5 |
| Grayck, M | 1 |
| McCarthy, WC | 1 |
| De Dios, RC | 1 |
| Zarate, MA | 1 |
| Orlicky, DJ | 2 |
| De Dios, R | 1 |
| Wright, CJ | 1 |
| Garcia-Ruiz, C | 5 |
| Fernandez-Checa, JC | 5 |
| Wei, H | 5 |
| Li, AP | 2 |
| Syafira, N | 1 |
| Graudins, A | 11 |
| Yarema, M | 2 |
| Wong, A | 15 |
| Moreno-Torres, M | 1 |
| García-Llorens, G | 1 |
| Moro, E | 1 |
| Méndez, R | 1 |
| Quintás, G | 1 |
| Castell, JV | 3 |
| Lim, JY | 1 |
| Yun, DH | 1 |
| Lee, JH | 8 |
| Kwon, YB | 1 |
| Lee, YM | 2 |
| Lee, DH | 3 |
| Kim, DK | 3 |
| Pourbagher-Shahri, AM | 1 |
| Schimmel, J | 2 |
| Shirazi, FM | 2 |
| Nakhaee, S | 2 |
| Li, X | 32 |
| Ge, J | 1 |
| Li, M | 16 |
| Deng, S | 2 |
| Ma, Y | 5 |
| Zhang, J | 38 |
| Zheng, Y | 9 |
| Ma, L | 8 |
| Hu, S | 2 |
| Yao, Y | 2 |
| Wei, ZY | 1 |
| Wang, SX | 1 |
| Wu, YC | 1 |
| Hu, Y | 3 |
| Yang, CC | 3 |
| Min, JL | 1 |
| Li, LY | 1 |
| Zhou, H | 8 |
| Yang, JF | 1 |
| Xu, T | 2 |
| Hodgson, SE | 1 |
| Herasymets, I | 1 |
| Fira, L | 1 |
| Medvid, I | 1 |
| Gong, L | 3 |
| Lei, L | 2 |
| Liang, S | 2 |
| Ai, J | 1 |
| Deng, X | 9 |
| Li, YQ | 1 |
| Zhang, TP | 1 |
| Pu, SB | 1 |
| Ren, YS | 2 |
| Chang, YM | 4 |
| Chen, PC | 1 |
| Hsu, CP | 1 |
| Ma, PF | 1 |
| Chen, HL | 3 |
| Hsu, SH | 1 |
| Hameed, H | 1 |
| Farooq, M | 1 |
| Piquet-Pellorce, C | 1 |
| Hamon, A | 1 |
| Samson, M | 1 |
| Le Seyec, J | 1 |
| Huang, Y | 7 |
| Xie, Y | 14 |
| Yang, D | 6 |
| Xiong, M | 1 |
| Wu, D | 2 |
| Wang, Q | 6 |
| Huang, K | 3 |
| Tashiro, S | 1 |
| Tanaka, M | 5 |
| Goya, T | 1 |
| Aoyagi, T | 1 |
| Kurokawa, M | 1 |
| Imoto, K | 1 |
| Kuwano, A | 1 |
| Takahashi, M | 2 |
| Suzuki, H | 1 |
| Kohjima, M | 1 |
| Kato, M | 1 |
| Ogawa, Y | 1 |
| Aprioku, JS | 1 |
| Gospel, P | 1 |
| Shah, KR | 2 |
| Beuhler, MC | 2 |
| Mudan, A | 1 |
| Lebin, JA | 1 |
| Wu, AHB | 1 |
| Livshits, Z | 2 |
| Thida, M | 1 |
| Li, B | 4 |
| Zhang, X | 30 |
| Chen, C | 20 |
| Zhang, Y | 26 |
| Liu, L | 9 |
| Li, N | 5 |
| Wang, Y | 70 |
| Yue, X | 1 |
| Tassinari, R | 1 |
| Cavallini, C | 1 |
| Olivi, E | 1 |
| Taglioli, V | 1 |
| Zannini, C | 1 |
| Ferroni, O | 1 |
| Ventura, C | 1 |
| Cai, Z | 1 |
| Wang, B | 4 |
| Zhou, Z | 10 |
| Zhao, X | 4 |
| Hu, L | 3 |
| Ren, Q | 1 |
| Deng, L | 1 |
| Li, Z | 14 |
| Wang, G | 9 |
| Thanacoody, HKR | 1 |
| Rani, R | 1 |
| Sharma, A | 3 |
| Wang, J | 24 |
| Kumar, S | 6 |
| Polaki, US | 1 |
| Gandhi, CR | 1 |
| Xu, P | 2 |
| Xi, Y | 1 |
| Wang, P | 10 |
| Luka, Z | 1 |
| Xu, M | 3 |
| Tung, HC | 1 |
| Ren, S | 6 |
| Feng, D | 3 |
| Gao, B | 3 |
| Singhi, AD | 1 |
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| York, JD | 1 |
| Ma, X | 15 |
| Huang, Z | 5 |
| Xie, W | 7 |
| Bateman, DN | 13 |
| Xu, L | 8 |
| Chen, W | 6 |
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| Zhang, R | 11 |
| Lee, MMS | 1 |
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| Karaarslan, U | 1 |
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| Friedman, N | 1 |
| Kim, K | 3 |
| Lasoff, D | 1 |
| Chatterjee, S | 2 |
| Bhattacharya, S | 3 |
| Choudhury, PR | 1 |
| Rahaman, A | 1 |
| Sarkar, A | 1 |
| Talukdar, AD | 1 |
| Mandal, DP | 1 |
| Souza, VD | 1 |
| Shetty, M | 1 |
| Badanthadka, M | 1 |
| Mamatha, BS | 1 |
| Vijayanarayana, K | 1 |
| Singh, H | 1 |
| Singh, T | 1 |
| Singh, AP | 1 |
| Kaur, S | 1 |
| Arora, S | 1 |
| Singh, B | 4 |
| Noda, T | 2 |
| Kato, R | 2 |
| Hattori, T | 1 |
| Furukawa, Y | 1 |
| Ijiri, Y | 2 |
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| Lyftogt, C | 2 |
| Draves, K | 3 |
| Furukawa, N | 1 |
| Sørensen, FB | 1 |
| Landbo, B | 1 |
| Marcussen, N | 1 |
| Picciòla, G | 1 |
| Zavaglio, G | 1 |
| Ravenna, F | 1 |
| Gentili, P | 1 |
| Tempra-Gabbiati, G | 1 |
| Carenini, G | 1 |
| Riva, M | 1 |
| Gale, GR | 1 |
| Atkins, LM | 1 |
| Smith, AB | 1 |
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| Procacci, V | 1 |
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| Lesser, PB | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenomics of APAP Induced DILI in Chinese Population.[NCT04964310] | 339 participants (Anticipated) | Observational | 2020-08-31 | Recruiting | |||
| Alterations of Gut Microbiota and Serum Biochemical Markers in Asian Patients With Drug-induced Liver Injury[NCT05465642] | 90 participants (Anticipated) | Observational [Patient Registry] | 2022-07-04 | Recruiting | |||
| Pharmacokinetics and Safety of Treatment With Paracetamol in Children and Adults With Spinal Muscular Atrophy and Cerebral Palsy[NCT03648658] | Phase 4 | 48 participants (Anticipated) | Interventional | 2019-02-18 | Recruiting | ||
| A Randomised Open Label Exploratory, Safety and Tolerability Study With PP100-01 in Patients Treated With the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose (The POP Trial)[NCT03177395] | Phase 1 | 24 participants (Actual) | Interventional | 2017-06-08 | Completed | ||
| CBD Cannabis Extract: Pharmacokinetic Studies[NCT04280289] | Early Phase 1 | 10 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | ||
| Effect on Acetaminophen Metabolism by Liquid Formulations: Do Excipients in Liquid Formulation Prevent Production of Toxic Metabolites?[NCT01246713] | 15 participants (Actual) | Interventional | 2010-12-31 | Completed | |||
| A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Effect of Race/Ethnicity and Genes on Acetaminophen Pharmacokinetics[NCT00768716] | Phase 4 | 95 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy on the Immune System Among Colorectal Cancer Patients[NCT03742596] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2018-11-07 | Withdrawn (stopped due to This study was closed without recruitment) | ||
| Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02596815] | 51 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02595294] | 52 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Use of Intravenous Acetaminophen in Adolescents and Pediatrics Undergoing Spinal Fusion Surgery: Randomized Controlled Trial[NCT04959591] | Phase 3 | 99 participants (Actual) | Interventional | 2021-06-01 | Completed | ||
| The Efficacy and Safety of 36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent Drug-Induced Liver Injury[NCT03266146] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2017-09-02 | Completed | ||
| Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678] | Phase 4 | 0 participants (Actual) | Interventional | 2014-02-28 | Withdrawn (stopped due to Investigator left institution) | ||
| Evaluation of MicroRNA Expression in Blood and Cytology Specimens as a Novel Method for Detecting Barrett's Esophagus[NCT02464930] | 220 participants (Anticipated) | Observational | 2015-04-30 | Recruiting | |||
| A Feasibility Study of Circulating microRNAs as Disease Markers in Pediatric Cancers[NCT01541800] | 20 participants (Anticipated) | Observational | 2010-03-31 | Recruiting | |||
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| Treatment of Acetaminophen Toxicity With Intravenous vs. Oral N-acetylcysteine: A Retrospective Review[NCT01465542] | 47 participants (Actual) | Observational | 2011-06-30 | Completed | |||
| Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity[NCT02353455] | 300 participants (Anticipated) | Observational | 2013-03-31 | Recruiting | |||
| Safety and Efficacy of Steroids in the Management of Fulminant Hepatic Failure Due to Hepatitis A Virus in the Pediatric Age Group[NCT02375867] | Phase 4 | 33 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Natural Compounds to Reduce Nitrite in Meat Products: PHYTOME[NCT04138654] | Phase 1 | 78 participants (Actual) | Interventional | 2014-04-17 | Completed | ||
| Evaluating the Effects of Acupuncture in the Treatment of Taxane Induces Peripheral Neuropathy (TIPN)[NCT02831114] | 18 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Full-Factorial, Parallel-Group Study Evaluating Safety and Efficacy of Naltrexone-Acetaminophen Combination in Acute Migraine Treatment in Adults, With Exploratory Focus on Co-Occurring[NCT05685225] | Phase 2 | 300 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2021-01-20 | Completed | ||
| Liver Injury by Statins in Coronary Heart Disease (CHD) Patients With History of Hepatitis B Virus (HBV) Infection[NCT02808299] | 600 participants (Anticipated) | Observational | 2016-12-31 | Not yet recruiting | |||
| A Multi-center, Randomized, Double-blind, Active Control Phase II Study to Investigate Multiple Dosage and Treatments of Magnesium Isoglycyrrhizinate Injection to Cure the Acute Drug-induced Liver Injury[NCT02734966] | Phase 2 | 174 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| A Double-blind Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Per and Post Hepatectomy Infiltrations for Adult Pain Management[NCT01194843] | 85 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| Disposition of Intravenous Paracetamol in Young Women, Including During Pregnancy, in Postpartum or When on Oral Contraceptives[NCT02590900] | 69 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| [NCT00137059] | 40 participants | Interventional | 2002-11-30 | Completed | |||
| [NCT00799578] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| Collection of Blood and Stool Samples in Patients With Acute Hepatitis[NCT00001879] | 200 participants | Observational | 1999-03-31 | Completed | |||
| Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088] | Phase 2 | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| NAC Attack, A Phase III, Multicenter, Randomized, Parallel, Double Masked, Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients With Retinitis Pigmentosa[NCT05537220] | Phase 3 | 438 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| IdB 1016 in Hepatitis C[NCT00055445] | Phase 1/Phase 2 | 45 participants | Interventional | 2003-11-30 | Completed | ||
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. (NCT03177395)
Timeframe: 10 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 41.4 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 22.9 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 25.3 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 15.0 |
The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. (NCT03177395)
Timeframe: 20 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 43.3 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 20.4 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 25.4 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 16.4 |
The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. (NCT03177395)
Timeframe: Baseline
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 42.5 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 24.6 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 29.4 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 17.7 |
Caspace-cleaved Keratin-18 (NCT03177395)
Timeframe: Ratio - value at 20 hours divided by baseline value for each patient
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 2.22 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.49 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.02 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.08 |
The shorter, Caspase cleaved form of K-18 is released following hepatocyte apoptosis (programmed cell death). (NCT03177395)
Timeframe: 10 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 72 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 53 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 56 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 78 |
The shorter, Caspase cleaved form of K-18 is released following hepatocyte apoptosis (programmed cell death). (NCT03177395)
Timeframe: 20 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 149 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 66 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 85 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 111 |
The shorter, Caspase cleaved form of K-18 is released following hepatocyte apoptosis (programmed cell death). (NCT03177395)
Timeframe: Baseline (2 hours)
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 67 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 45 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 84 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 104 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: 10 hours
| Intervention | ratio (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.30 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.17 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.20 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.22 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: 20 hours
| Intervention | ratio (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.18 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.07 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.08 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.22 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: Baseline
| Intervention | ratio (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.02 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.00 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 0.98 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.05 |
international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF) (NCT03177395)
Timeframe: value at 20 hours divided by baseline value for each patient
| Intervention | ratio (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.15 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.07 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.10 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.10 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: 20 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 347 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 229 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 172 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 181 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: Baseline (2 hours)
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 187 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 177 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 193 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 128 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: Ratio - value at 20 hours divided by baseline value for each patient
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.85 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 1.29 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 0.89 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.41 |
In paracetamol overdose, the full-length variant of Keratin-18 (K-18) is released by necrotic hepatocyte death. (NCT03177395)
Timeframe: 10 hours
| Intervention | U/L (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 182 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 152 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 170 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 111 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 20 hours
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 216,256 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 57,664 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 202,271 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 40,745 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: Baseline (2 h)
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 146,363 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 116,749 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 194,075 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 36,051 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: Ratio - value at 20 hours divided by baseline value for each patient
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 1.48 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 0.49 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 1.04 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 1.13 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 10 hours
| Intervention | DCt (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 5.41 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 6.14 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 5.01 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 9.00 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 20 hours
| Intervention | DCt (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 4.85 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 7.12 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 4.49 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 8.44 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: Baseline (2 hours)
| Intervention | DCt (Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 5.58 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 5.85 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 4.43 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 8.73 |
MiR-122 is a biomarker specific for liver injury and fully conserved (translational) across in vitro models, in vivo models and humans. MiR-122 is an early marker for acute liver injury which predicts a rise in ALT activity following paracetamol overdose (NCT03177395)
Timeframe: 10 hours
| Intervention | copies/mcL (Geometric Mean) |
|---|---|
| Acetylcysteine (N-acetylcysteine; NAC) | 206,205 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 109,882 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 196,732 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 37,066 |
participants required additional NAC infusions after the 12-hour NAC regimen (NCT03177395)
Timeframe: Additional NAC at 12 hour
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| None | One | Two | |
| Acetylcysteine (N-acetylcysteine; NAC) | 3 | 1 | 2 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 5 | 1 | 0 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 6 | 0 | 0 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 6 | 0 | 0 |
Adverse Events and Serious Adverse Events (NCT03177395)
Timeframe: 90 days
| Intervention | participants (Number) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any Adverse event | Any serious adverse event | Adverse event after commencement of NAC treatment | Serious AE after commencement of NAC treatment | Adverse event where outcome was death | Adverse event unrelated to NAC | Adverse event possibly related to NAC | Adverse event probably related to NAC | Adverse event definitely related to NAC | Adverse event unrelated to PP100-01 | Adverse event possibly related to PP100-01 | Adverse event probably related to PP100-01 | Adverse event definitely related to PP100-01 | Any suspected unexpected serious adverse reaction | SUSAR to NAC | SUSAR to PP100-01 | SUSAR to NAC and PP100-01 | |
| Acetylcysteine (N-acetylcysteine; NAC) | 6 | 2 | 6 | 1 | 0 | 3 | 2 | 3 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Group A: PP100-01 (Calmangafodipir 2 Umol/kg)+ NAC | 6 | 4 | 5 | 1 | 0 | 5 | 2 | 2 | 3 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Group B: PP100-01 (Calmangafodipir 5 Umol/kg)+ NAC | 6 | 2 | 6 | 1 | 1 | 3 | 2 | 3 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Group C: PP100-01 (Calmangafodipir 10 Umol/kg)+ NAC | 6 | 3 | 6 | 2 | 0 | 5 | 2 | 2 | 1 | 6 | 2 | 0 | 0 | 1 | 0 | 1 | 0 |
Area-under-curve from time zero to 8 hours for APAP-cysteinate metabolite. Serum was collected just prior to and at hours 1, 2, 4, 6, and 8 after administration of the APAP dose. (NCT01246713)
Timeframe: 8 hours
| Intervention | mcg.hr/ml (Mean) |
|---|---|
| Acetaminophen Solid Formulation | 2.411 |
| Acetaminophen Liquid Formulation | 2.009 |
Acetaminophen glucuronidation partial clearance determined from plasma clearance and urinary metabolite excretion (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| White Subjects | 2.9 |
| Black Subjects | 3.3 |
The association of acetaminophen glucuronidation partial clearance with UGT2B15 genotype (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| UGT2B15*1/*1 | 3.8 |
| UGT2B15*1/*2 | 2.8 |
| UGT2B15*2/*2 | 2.1 |
Acetaminophen oxidation partial clearance determined from plasma clearance and urinary metabolite excretion (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| White Subjects | 0.9 |
| Black Subjects | 0.57 |
Plasma total clearance of acetaminophen in plasma measured by HPLC (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| White Subjects | 5.3 |
| Black Subjects | 5.9 |
The association of UGT2B15 genotype with acetaminophen total clearance (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| UGT2B15*1/*1 | 6.4 |
| UGT2B15*1/*2 | 5.5 |
| UGT2B15*2/*2 | 4.7 |
Acetaminophen sulfation partial clearance determined from plasma clearance and urinary metabolite excretion (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| White Subjects | 1.4 |
| Black Subjects | 1.7 |
The association of UGT2B15 genotype with APAP plasma adduct concentrations (NCT00768716)
Timeframe: 2 days
| Intervention | mL/min/kg (Median) |
|---|---|
| UGT2B15*1/*1 | 16 |
| UGT2B15*1/*2 | 19 |
| UGT2B15*2/*2 | 27 |
Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours
| Intervention | IV morphine mg equivalents (Mean) |
|---|---|
| Placebo | 19.4 |
| N-acetylcysteine (NAC) | 15.6 |
Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours
| Intervention | IV morphine mg equivalents (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 6 hours | 18 hours | 24 hours | 30 hours | 36 hours | 42 | 48 | |
| N-acetylcysteine (NAC) | 12.0 | 19.9 | 24.7 | 27.2 | 29.7 | 33.1 | 34.9 |
| Placebo | 14.6 | 25.0 | 29.6 | 34.0 | 37.9 | 40.9 | 43.3 |
(NCT00799578)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Number of Improved Subjects | 7 |
Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | 0.99 |
| N-acetylcysteine | 0.74 |
Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours
| Intervention | L/min/m2 (Mean) |
|---|---|
| Placebo | 0.68 |
| N-acetylcysteine | 0.29 |
Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Placebo | 96 |
| N-acetylcysteine | 176 |
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
298 reviews available for acetaminophen and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Metabolomics as a Truly Translational Tool for Precision Medicine.
Topics: Acetaminophen; Animals; Anticonvulsants; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; | 2021 |
Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.
Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Fomepizole; Humans | 2022 |
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induc | 2022 |
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemical a | 2022 |
Management of Pharmacologic Adverse Effects in Advanced Liver Disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Liver; Liver Disea | 2022 |
Targeting innate immune responses to attenuate acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Immunity, Innate; Liver; Mic | 2022 |
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Combinations; Glycosides; Kelch | 2022 |
Progress in the treatment of drug-induced liver injury with natural products.
Topics: Acetaminophen; Biological Products; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; H | 2022 |
A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals.
Topics: Acetaminophen; Animals; Animals, Laboratory; Chemical and Drug Induced Liver Injury; Drug-Related Si | 2022 |
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and D | 2022 |
Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations.
Topics: Acetaminophen; Animals; Biological Products; Chemical and Drug Induced Liver Injury; Liver; Mice; Mi | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2023 |
The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Oxidative Stress | 2023 |
[c-Jun N-terminal kinase signaling pathway in acetaminophen-induced liver injury].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Acetaminophen-Induced Liver Damage in Hepatic Steatosis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hepatocytes; Humans; No | 2020 |
Emerging and established modes of cell death during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; Ferroptosis; | 2019 |
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Aus | 2020 |
Pathophysiology of Acute Liver Failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2020 |
Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2020 |
Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2020 |
Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2020 |
Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; DNA Fragmenta | 2020 |
A mitochondrial journey through acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; MAP Ki | 2020 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Acetaminophen Oxidation and Inflammatory Markers - A Review of Hepatic Molecular Mechanisms and Preclinical Studies.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Inflammation; Ox | 2020 |
Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system.
Topics: Acetaminophen; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytokines; Disea | 2020 |
Acetaminophen Test Battery (ATB): A Comprehensive Method to Study Acetaminophen-Induced Acute Liver Injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2020 |
Autophagy: a promising process for the treatment of acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Autophagy; Chemical and Drug Induced Liver Injury; Hepatocy | 2020 |
Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Antidotes; Antioxidants; Autophagy; Chemical and Drug Induced Liver Injury; | 2020 |
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Over | 2020 |
Latex Proteins from
Topics: Acetaminophen; Animals; Apocynaceae; Chemical and Drug Induced Liver Injury; Cytokines; Latex; Liver | 2020 |
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Huma | 2020 |
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential.
Topics: Acetaminophen; Animals; Biochemical Phenomena; Carcinogens; Chemical and Drug Induced Liver Injury; | 2021 |
Paracetamol overdose in the newborn and infant: a life-threatening event.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2021 |
Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Ferroptosi | 2021 |
Role of Noncoding RNAs in Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2021 |
The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Humans; Inflamm | 2021 |
[Research progress on hepatotoxicity of acetaminophen].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2021 |
The complex roles of neutrophils in APAP-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Movement; Chemical and Drug Induced Liver Inj | 2021 |
Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2021 |
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Consensus; Europe; Humans; Liver | 2021 |
A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Che | 2021 |
The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biological Products; Chemical and Drug Induced Liv | 2021 |
Liver transplantation for drug-induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Failu | 2017 |
Risk prediction of hepatotoxicity in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antioxidants; Biomark | 2017 |
Acetaminophen (APAP) hepatotoxicity-Isn't it time for APAP to go away?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Failure, Acute; | 2017 |
Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytoprotec | 2017 |
Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Humans; Mi | 2018 |
Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Risk Factor | 2018 |
Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 2018 |
Systematic review: non A-E, seronegative or indeterminate hepatitis; what is this deadly disease?
Topics: Acetaminophen; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Hepatitis; Humans; Liver | 2018 |
Classification and Epidemiologic Aspects of Acute Liver Failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hepatitis, Viral, Human; Humans; Liver Failur | 2018 |
Dissecting the molecular pathophysiology of drug-induced liver injury.
Topics: Acetaminophen; Adaptive Immunity; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug In | 2018 |
Role and mechanisms of autophagy in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Disease Models, Animal; H | 2018 |
Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.
Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu | 2018 |
Autophagy and acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; | 2018 |
What dose of paracetamol for older people?
Topics: Acetaminophen; Age Factors; Aged, 80 and over; Analgesics; Chemical and Drug Induced Liver Injury; D | 2018 |
The role of apoptosis in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Caspases; Chemical and Drug Induced L | 2018 |
Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Glutathione; Humans; | 2018 |
Re-Examining Safety Protocols for Tylenol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2017 |
Acute liver failure: A review for emergency physicians.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Emergency Service, Hospital; Hepatic Encephal | 2019 |
DAMPs and sterile inflammation in drug hepatotoxicity.
Topics: Acetaminophen; Alarmins; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injur | 2019 |
Acute Liver Failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Critical Care; Drug Overdose; Hepatitis, Auto | 2018 |
Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Liver; Oxidativ | 2018 |
Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and D | 2019 |
Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2019 |
What is the most appropriate dose of
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dos | 2019 |
Rheumatologic Diseases and the Liver.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthralgia; Biological | 2019 |
Animal models of drug-induced liver injury.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2019 |
Safety of Paracetamol in Osteoarthritis: What Does the Literature Say?
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthralgia; Chemical and Drug Induced Liver Injury; D | 2019 |
Acetaminophen hepatotoxicity: A mitochondrial perspective.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; | 2019 |
Evaluation and treatment of acetaminophen toxicity.
Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Disease Progression; | 2019 |
Cell death in drug-induced liver injury.
Topics: Acetaminophen; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Liv | 2019 |
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Chemical and Drug Induced Liver Inju | 2013 |
Order in the house. Setting standards for treatment of acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Nurse Pract | 2013 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
[Acetaminophen and the liver: damage at therapeutic dose levels?].
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2011 |
Liver abnormalities in drug and substance abusers.
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrho | 2013 |
Acetaminophen-related hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induced Liv | 2013 |
Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Humans; Mitochondria; Nec | 2013 |
Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology.
Topics: Acetaminophen; Animals; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Depressive Dis | 2014 |
The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease.
Topics: Acetaminophen; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; He | 2014 |
Toxin-induced hepatic injury.
Topics: Acetaminophen; Alcohols; Amanita; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induc | 2014 |
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Chemical an | 2014 |
Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3 | 2014 |
Update in intensive care medicine: acute liver failure. Initial management, supportive treatment and who to transplant.
Topics: Acetaminophen; Antiviral Agents; Chemical and Drug Induced Liver Injury; Critical Care; Female; Hepa | 2014 |
A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2014 |
[Molecular mechanism of acute acetaminophen intoxication].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Chemical and Drug Induced Liver Inju | 2014 |
Drug-induced liver injury: what was new in 2013?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dr | 2014 |
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.
Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Model | 2014 |
Mechanisms of drug-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Oxidative S | 2014 |
Cyclophilin inhibition as potential therapy for liver diseases.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cyclophil | 2014 |
New problems arising from old drugs: second-generation effects of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Asthma; Chemical and Drug Induced Liver Injury; Ch | 2014 |
Transcriptomic studies on liver toxicity of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Gene Expre | 2014 |
[Hepatoprotective effects of extracts and polysaccharides from seaweed].
Topics: Acetaminophen; Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Li | 2014 |
Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Clinical T | 2015 |
Translational biomarkers of acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2015 |
Intravenous acetaminophen use in pediatrics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bicycling; Body Weight; Chemic | 2015 |
Inflammasome activation and function in liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disease Prog | 2015 |
Target biomarker profile for the clinical management of paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2015 |
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Cell Death; | 2015 |
Sterile inflammation in acute liver injury: myth or mystery?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatitis; HMGB1 Protei | 2015 |
Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug O | 2015 |
Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Dose-Response Relationship, | 2016 |
Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Computer Simulation; Dru | 2015 |
[In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans].
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chimera; Humans; Li | 2015 |
Experimental models of hepatotoxicity related to acute liver failure.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease M | 2016 |
Targeting Pink1-Parkin-mediated mitophagy for treating liver injury.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Ethanol; Liver; Mitochond | 2015 |
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Chemical | 2016 |
Xenobiotics and loss of tolerance in primary biliary cholangitis.
Topics: Acetaminophen; Animals; Autoantibodies; Autoantigens; Chemical and Drug Induced Liver Injury; Cholan | 2016 |
The changing face of liver transplantation for acute liver failure: Assessment of current status and implications for future practice.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Con | 2016 |
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Brain; Chemical and Drug Induced Liver Injury; Humans; Liver | 2016 |
Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?
Topics: Acetaminophen; Biomarkers; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adv | 2016 |
Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Antipyretics; Chemical and Drug Indu | 2016 |
Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2016 |
Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Repositioning; Lipid Peroxidati | 2016 |
Drug Hepatotoxicity: Environmental Factors.
Topics: Acetaminophen; Alcohol Drinking; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Envi | 2017 |
Drug-induced liver injury: Advances in mechanistic understanding that will inform risk management.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2017 |
Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Inflammasomes; Liver Failure | 2017 |
Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Biotransformation; Chemic | 2008 |
[Weak opioids. Pain and Locoregional Anesthesia Committee and the Standards Committee of the French Society of Anesthesia and Intensive Care].
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2009 |
Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Diabetes M | 2009 |
Adverse reactions associated with acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Anaphylaxis; Antidote | 2009 |
Emergency: acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Chemical and Drug Induced Liver Inju | 2009 |
Signal transduction pathways involved in drug-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 2010 |
Mechanisms of acetaminophen-induced liver necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 2010 |
Bactrian ("double hump") acetaminophen pharmacokinetics: a case series and review of the literature.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2010 |
[Are nomograms available for the treatment of acetaminophen poisoning? Limitation of Rumack & Matthew nomogram for evaluation of hepatotoxicity].
Topics: Acetaminophen; Biomarkers; Chemical and Drug Induced Liver Injury; Contraindications; Humans; Liver | 2010 |
Predicting and preventing acute drug-induced liver injury: what's new in 2010?
Topics: Acetaminophen; Adult; Aged; Aging; Alanine Transaminase; Amoxicillin-Potassium Clavulanate Combinati | 2010 |
Acute liver failure.
Topics: Acetaminophen; Ammonia; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Emergency | 2010 |
The application of metabonomics to predict drug-induced liver injury.
Topics: Acetaminophen; Animals; Azetidines; Benzylamines; Chemical and Drug Induced Liver Injury; Clinical T | 2010 |
[Prolonged fever and jaundice in a patient with alcoholic liver disease].
Topics: Acetaminophen; Adult; Animals; Animals, Domestic; Antibodies, Bacterial; Antipyretics; Ascites; Chem | 2010 |
The potential of cytokines as safety biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Anesthetics, Inhalation; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; | 2010 |
Liver injury caused by drugs: an update.
Topics: Acetaminophen; Adaptive Immunity; Analgesics, Non-Narcotic; Antitubercular Agents; Apoptosis; Chemic | 2010 |
Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Computational Biology; Dose-Response | 2011 |
Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 2011 |
Intravenous acetylcysteine for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Antidotes; Chemical and Drug Ind | 2011 |
[Intentional paracetamol intoxication in children].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2011 |
Mechanisms of drug-induced liver injury: from bedside to bench.
Topics: Acetaminophen; Animals; Azetidines; Benzylamines; Chemical and Drug Induced Liver Injury; Diclofenac | 2011 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Analgesics, Non-Narcotic; Antidotes; Chemical and Dr | 2011 |
Drug-induced liver injury: a summary of recent advances.
Topics: Acetaminophen; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Biomarkers; Catha; Chem | 2011 |
An update on drug induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Chemical and Drug Induced Liver Inju | 2011 |
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.
Topics: Acetaminophen; Animals; Autoimmunity; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; I | 2012 |
Lack of toxicity after paracetamol overdose in a extremely preterm neonate.
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced L | 2012 |
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Indu | 2012 |
Acetylcysteine therapy for acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Clinical Trials as | 2012 |
[Drug-induced liver injury].
Topics: Acetaminophen; Algorithms; Amoxicillin; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Bact | 2012 |
Acetaminophen and Ibuprofen overdosage.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Chemical and Drug Induced Live | 2012 |
Drug-induced liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hepatitis E; Humans; Prognosis; Risk Factors | 2012 |
Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug | 2012 |
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Death; | 2012 |
Sterile inflammation in the liver.
Topics: Acetaminophen; Adenosine Triphosphate; Caspase 1; Chemical and Drug Induced Liver Injury; Chemotaxis | 2012 |
Low rates of hepatotoxicity among Asian patients with paracetamol overdose: a review of 1024 cases.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asian People; Chemical and Drug Induced Liver Injury; Drug | 2012 |
On mechanisms of reactive metabolite formation from drugs.
Topics: Acetaminophen; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys | 2013 |
Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics.
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Ag | 2012 |
Protective effects of nicotinamide against acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Niacinamid | 2012 |
[Paracetamol. Efficacious and safe for all ages].
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
[Severe paracetamol poisoning complicated with liver and renal failure--case report and review of literature].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2012 |
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2002 |
Chronic acetaminophen toxicity: a case report and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Humans; Mid | 2002 |
[Practical analysis of toxic substances useful for clinical toxicology--4--Acetaminophen].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Chromatography, High P | 2002 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroida | 2003 |
Acetaminophen intoxication and length of treatment: how long is long enough?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical a | 2003 |
Role of nitric oxide in liver injury.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Liver; Liver Diseases; N | 2003 |
New insights into haemostasis in liver failure.
Topics: Acetaminophen; Acute Disease; Antithrombins; Blood Coagulation Disorders; Blood Coagulation Factors; | 2003 |
Acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2003 |
[Tolerability of paracetamol].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Bias; Case-Control Studies; Chemical and Drug Induced Liver | 2003 |
[New perspectives on paracetamol].
Topics: Acetaminophen; Administration, Oral; Advertising; Analgesics, Non-Narcotic; Chemical and Drug Induce | 2003 |
Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug and Narcotic C | 2005 |
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; | 2005 |
Tolerability of paracetamol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Molecular Structure; Treatment Outcom | 2005 |
Drug-induced hepatotoxicity: 2005.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromans; Female; Humans; Hydroxymethylglutar | 2005 |
An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Chemic | 2005 |
Drug-induced liver disease 2004.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Retroviral Agents; Antitubercular Agents; Chemical and | 2005 |
Acetaminophen overdose in pregnancy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2005 |
The molecular toxicology of acetaminophen.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2005 |
Liver biology and pathobiology.
Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Diseases, Alc | 2006 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster | 2006 |
Sinusoidal endothelial cells as an early target for hepatic toxicants.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2006 |
Drug-induced liver disease.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Alanine Transaminase; Analgesics, Non-Narcot | 2006 |
[Is there a risk to prescribe paracetamol at therapeutic doses in patients with acute or chronic liver disease?].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chro | 2006 |
[Problems with therapeutic acetaminophen use in excessive drinkers].
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 2006 |
Role of innate immunity in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemokines | 2006 |
Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; DNA Fragme | 2005 |
[Drug-induced liver injury].
Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; | 2006 |
Mitochondrial involvement in drug-induced hepatic injury.
Topics: Acetaminophen; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; | 2006 |
Selection of new chemical entities with decreased potential for adverse drug reactions.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Design; Drug-R | 2006 |
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2007 |
Drug-induced liver disease in 2006.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Chemical and Drug Induced L | 2007 |
Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Commerce; Drug Over | 2007 |
Evidence for practice: education about the dangers of acetaminophen.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Overdose; Fema | 2007 |
Clinical inquiries. Alcoholic liver disease: is acetaminophen safe?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea | 2007 |
Acetaminophen safety and hepatotoxicity--where do we go from here?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Liver Failur | 2007 |
Mechanisms of drug-induced liver disease.
Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adve | 2007 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver | 2007 |
[Heme oxygenase as a potential therapeutic target for hepatoprotection].
Topics: Acetaminophen; Animals; Biliverdine; Carbon Monoxide; Catalysis; Cells, Cultured; Chemical and Drug | 2007 |
[Abnormality of liver functional test in patients with drug-induced liver injury].
Topics: Acetaminophen; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovas | 2007 |
[Drug-induced hepatitis].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics; Anti-Infective Agents; Anti-Inflammatory Agent | 2007 |
[Fulminant hepatitis].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Age | 2007 |
COX-2 selective inhibitors in the treatment of osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl | 2008 |
Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2008 |
Paracetamol overdosage. Pharmacological considerations and clinical management.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Glutathione; Hear | 1983 |
Treatment of fever in 1982: a review.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Chemical and Dr | 1983 |
The treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotran | 1983 |
Nonprescription analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1983 |
Drug induced liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis | 1983 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Chemical and Drug Induced Liver Injury; | 1983 |
Drug interactions affecting analgesic toxicity.
Topics: Acetaminophen; Alcoholic Intoxication; Alcoholism; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 1983 |
Use of antipyretic analgesics in the pediatric patient.
Topics: Acetaminophen; Adolescent; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemic | 1983 |
Hepatotoxicity following the therapeutic use of antipyretic analgesics.
Topics: Acetaminophen; Alcohol Drinking; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 1983 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Chemical Phenomena; | 1984 |
Reactive metabolites as a cause of hepatotoxicity.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Drug-Related Side | 1983 |
Mechanisms of cell injury with hepatotoxic chemicals.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1984 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; | 1984 |
In vitro human pharmacogenetics of reactive drug metabolite detoxification.
Topics: Acetaminophen; Anticonvulsants; Cells, Cultured; Chemical and Drug Induced Liver Injury; Ethers, Cyc | 1983 |
The use of non-prescription analgesics in an older population.
Topics: Acetaminophen; Aged; Analgesics; Aspirin; Blood Coagulation; Chemical and Drug Induced Liver Injury; | 1982 |
[Hepatitis caused by drugs. II].
Topics: Acetaminophen; Amanitins; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Humans; Pha | 1982 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; C | 1980 |
Hepatotoxicity of mild analgesics.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Chemical and Drug Induced Liver Injury; Child; Humans; Ph | 1980 |
Paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Cystea | 1980 |
[Paracetamol: overdose and hepatic lesions].
Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain | 1981 |
Metabolic activation and toxicology - some models of chemical protection against drug toxicity.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chloroform; Cytoc | 1981 |
Treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Liver | 1981 |
Maternal and fetal effects of acetaminophen and salicylates in pregnancy.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Chemical and Drug Induced Liver I | 1981 |
Acetaminophen toxicity: report of case and review of the literature.
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Blood Coagulation; Chemical and Drug Ind | 1995 |
Hepatotoxicity: newer aspects of pathogenesis and treatment.
Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; | 1995 |
Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclohexane Monoterpenes; Humans; Me | 1995 |
The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen.
Topics: Acetaminophen; Animals; Binding, Competitive; Chemical and Drug Induced Liver Injury; Liver; Microso | 1995 |
[Fulminant hepatitis: pathogenesis, clinical aspects and management].
Topics: Acetaminophen; Adult; Brain Edema; Chemical and Drug Induced Liver Injury; Hemorrhage; Hepatic Encep | 1994 |
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders].
Topics: Acetaminophen; Acetylcysteine; Acquired Immunodeficiency Syndrome; Antioxidants; Chemical and Drug I | 1994 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Enceph | 1993 |
Paracetamol poisoning and the kidney.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Drug Ove | 1993 |
Management of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Poisoning | 1996 |
[Drug induced liver injury].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1995 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1995 |
[Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 1996 |
Classification, etiology, and considerations of outcome in acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa | 1996 |
Nonnarcotic analgesics: prevalence and estimated economic impact of toxicities.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical | 1997 |
Acetaminophen use in children: more is not better.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; | 1997 |
Acetaminophen-induced hepatotoxicity: predisposing factors and treatments.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Animals; Causality; Chemical and Drug Ind | 1997 |
Selective protein covalent binding and target organ toxicity.
Topics: Acetaminophen; Animals; Binding, Competitive; Chemical and Drug Induced Liver Injury; Halothane; Hex | 1997 |
Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Biotrans | 1998 |
Hepatotoxicity of non-narcotic analgesics.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 1998 |
Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens.
Topics: Acetaminophen; Adult; Alcohol Drinking; Animals; Biotransformation; Carcinogens; Chemical and Drug I | 1998 |
[Severe hepatitis from therapeutic doses of paracetamol in an alcoholic patient].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced | 1999 |
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Cha | 1999 |
[Hepatotoxicity caused by therapeutic doses of paracetamol in alcoholics. Report of 2 cases of fatal hepatitis in cirrhosis].
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 1999 |
Acetaminophen intoxication during treatment: what you don't know can hurt you.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdo | 2000 |
Paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinogens; Chemical and Drug Induced Liver Injur | 1999 |
PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Drug Resistance; Hypolip | 2000 |
Drug-induced liver disease.
Topics: Acetaminophen; Alanine Transaminase; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2000 |
Acetaminophen (Tylenol): Johnson & Johnson and consumer safety.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Consumer Product Sa | 1997 |
Management of drug-induced liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholestasis; Drug O | 2001 |
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemopreve | 2001 |
Role of macrophages and inflammatory mediators in chemically induced toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation Mediators; Liver Diseas | 2001 |
Management of paracetamol overdose: current controversies.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 2001 |
Metastatic small cell carcinoma presenting as acute hepatic failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Di | 2001 |
Toxic interaction of didanosine and acetaminophen leading to severe hepatitis and pancreatitis: a case report and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Di | 2001 |
Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors.
Topics: Acetaminophen; Adult; Aged; Chemical and Drug Induced Liver Injury; Databases, Bibliographic; Female | 2002 |
Acetaminophen poisoning: an update for the intensivist.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cri | 2002 |
Alcohol exposure and paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Alcohol Drinking; Alcoholism; Chemical and Drug Induced Liver Injury; Dose-Response R | 2002 |
Effective use of analgesic drugs.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast | 1976 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; | 1977 |
Hepatotoxicity: pathogenesis and therapeutic intervention.
Topics: Acetaminophen; Anabolic Agents; Androgens; Animals; Chemical and Drug Induced Liver Injury; Cysteami | 1979 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
Drug metabolism in liver disease.
Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H | 1975 |
Acute liver injury.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati | 1975 |
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases | 1992 |
Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Aging; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans | 1992 |
Assessment and treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Ove | 1991 |
Paracetamol poisoning in children and hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Infant | 1991 |
[Paracetamol hepatotoxicity].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Huma | 1990 |
[Current status of the study of mechanisms of liver injury caused by some commonly used hepatotoxic agents].
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gala | 1990 |
Molecular mechanisms of the hepatotoxicity caused by acetaminophen.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Drug Interactions; Hu | 1990 |
Mechanism of dimethylsulfoxide protection against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Humans | 1989 |
[Hepatotoxicity of drugs commonly used in rheumatology].
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Dextrop | 1985 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
Hepatotoxic and hepatoprotective potential of histamine (H2)-receptor antagonists.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Histamine H2 Anta | 1987 |
Free radicals of acetaminophen: their subsequent reactions and toxicological significance.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chemical Phenomena; C | 1986 |
[Hepatotoxicity from therapeutic doses of paracetamol in different clinical situations].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans | 1988 |
Current status of aspirin and acetaminophen intoxication.
Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Gastrointestinal Diseases; Humans; R | 1987 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
Pediatric toxicology: current controversies and recent advances.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child Ab | 1986 |
Protective agents for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimet | 1986 |
Xenobiotics, drug metabolism, and liver injury.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liv | 1987 |
Liver damage with non-narcotic analgesics.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 1986 |
Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Ethanol; Humans; Liver; Liver Dis | 1987 |
[Etiology of hepatic injuries and sensitivity of the liver].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Inactivation, Met | 1985 |
[Therapy of toxic hepatitis].
Topics: Acetaminophen; Acetylcysteine; Adrenal Cortex Hormones; Age Factors; Aged; Animals; Chemical and Dru | 1985 |
[Toxic hepatitis induced by anti-inflammatory agents].
Topics: Acetaminophen; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivi | 1985 |
The biochemical pathology of toxic cell death.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membra | 1985 |
[Recent findings on the hepatotoxicity of drugs].
Topics: Acetaminophen; Alcoholism; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytoc | 1985 |
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics].
Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adv | 1985 |
The adverse effects of drugs on the liver.
Topics: Acetaminophen; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; | 1973 |
46 trials available for acetaminophen and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Short-Term High-Fat Diet Alters Acetaminophen Metabolism in Healthy Individuals.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Diet, High-Fat; Huma | 2022 |
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antibiotics | 2023 |
A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation.
Topics: Acetaminophen; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Genome-Wide Association | 2023 |
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; | 2020 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Hepatic Adaptation to Therapeutic Doses of Acetaminophen: An Exploratory Study in Healthy Individuals.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Live | 2020 |
A Randomized Controlled Trial of Intravenous N-Acetylcysteine in the Management of Anti-tuberculosis Drug-Induced Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Chemical and Drug Induced Liver I | 2021 |
The Effects of Silymarin on Acetaminophen-Induced Acute Hepatic and Renal Toxicities in Domestic Pigeons (
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bird Diseases; Chemic | 2020 |
A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; | 2021 |
The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Alanine Transaminase; Chemical and Drug Induced Li | 2019 |
Inhibition of CYP2E1 With Propylene Glycol Does Not Protect Against Hepatocellular Injury in Human Acetaminophen Daily-Dosing Model.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; C | 2019 |
Study of glutathione S-transferase levels in patients receiving intravenous paracetamol perioperatively: A randomized controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Double-Blind M | 2018 |
Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Biotransforma | 2019 |
N-acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double-blind controlled trial in healthy subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced | 2019 |
Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Trials Data Monitori | 2019 |
Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).
Topics: Acetaminophen; Acetylcysteine; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Inter | 2019 |
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemical and Drug I | 2013 |
Pattern recognition analysis for hepatotoxicity induced by acetaminophen using plasma and urinary 1H NMR-based metabolomics in humans.
Topics: Acetaminophen; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Hydrogen; Magnetic | 2013 |
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Antidotes; Chemical a | 2014 |
Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Dr | 2016 |
Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.
Topics: Acetaminophen; Adult; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Down-Regulation; | 2010 |
Evaluation of prophylactic and therapeutic effects of silymarin and N-acetylcysteine in acetaminophen-induced hepatotoxicity in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Bilirubin; Cat Diseases; Cats; Chemical and Drug Induced Liv | 2010 |
Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Alcoholism; Biomarkers; Chemical and Drug Induce | 2011 |
Circulating microRNAs as potential markers of human drug-induced liver injury.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcoti | 2011 |
'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Respons | 2012 |
Effectiveness of FDA's new over-the-counter acetaminophen warning label in improving consumer risk perception of liver damage.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Consumer Hea | 2012 |
Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial.
Topics: Acetaminophen; Adult; Alcohol Deterrents; Analgesics, Non-Narcotic; Blood Pressure; Chemical and Dru | 2003 |
Does acetaminophen affect liver function in alcoholic patients?
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Double- | 2003 |
S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury.
Topics: Acetaminophen; Animals; Antioxidants; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Er | 2003 |
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases | 2005 |
Are recommended doses of acetaminophen hepatotoxic for recently abstinent alcoholics? A randomized trial.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Aminotra | 2008 |
Clinical safety of high oral doses of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases | 1983 |
Paracetamol self-poisoning. Characteristics, prevention and harm reduction.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Delayed-Action Preparation | 1996 |
Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Chemical | 1998 |
Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Adult; Aged; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dos | 2001 |
Acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; | 1977 |
Controlled trial of cysteamine and dimercaprol after paracetamol overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cysteamine; Dimerca | 1977 |
Drug therapy. Acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Body Temperature; Chemical and Drug Induced Liver Injury; | 1976 |
Proceedings: Controlled trial of cysteamine and dimercaprol in the prevention of liver damage after paracetamol overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cysteamine; Dimerca | 1975 |
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Biological Transport; Chemical and Drug Induced Li | 1991 |
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overd | 1991 |
Letter: Treatment of paracetamol poisoning.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1974 |
Letter: Cysteamine for paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch | 1974 |
Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.
Topics: Acetaminophen; Administration, Oral; Charcoal; Chemical and Drug Induced Liver Injury; Cholestyramin | 1973 |
A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Adolescent; Adult; Blood Coagulation Disorders; Blood Transfusion; Chemical and Drug | 1974 |
2670 other studies available for acetaminophen and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Comparative toxicities and analgesic activities of three monomethylated analogues of acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemi | 1986 |
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cyste | 1982 |
Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Femal | 1980 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Synthesis, hepatotoxic evaluation and antipyretic activity of nitrate ester analogs of the acetaminophen derivative SCP-1.
Topics: Acetaminophen; Animals; Antipyretics; Chemical and Drug Induced Liver Injury; Crystallography, X-Ray | 2018 |
A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis.
Topics: Acetamides; Acetic Acid; Analgesics; Animals; Antipyretics; Chemical and Drug Induced Liver Injury; | 2020 |
Trimethylamine N-oxide exacerbates acetaminophen-induced liver injury by interfering with macrophage-mediated liver regeneration.
Topics: Acetaminophen; Aged; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Live | 2022 |
[A protective effect of acetaminophen on ibuprofen-induced small intestinal damage in rats via the suppression of MMP-13].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Ibuprofen; Intestine, Small; Liver; | 2021 |
A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coordination Complexes; Iridium; Kel | 2021 |
Inhibition of Drug-Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Chemokine | 2021 |
C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation.
Topics: Acetaminophen; Animals; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Chemical and Dru | 2022 |
In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Chemical and Drug Induced Liver | 2021 |
Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Liver; Male; Mi | 2021 |
Letter to the Editor: Rethinking public health measures to reduce liver injury from therapeutic acetaminophen ingestion.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eating; Humans; Liv | 2022 |
Integration of transcriptomics and metabolomics confirmed hepatoprotective effects of steamed shoot extracts of ginseng (Panax ginseng C.A. Meyer) on toxicity caused by overdosed acetaminophen.
Topics: Acetaminophen; Amino Acids; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Bile Acids a | 2021 |
Hepatic NF-κB-Inducing Kinase and Inhibitor of NF-κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Ferroptosis; Hepatocytes; Lipid Pero | 2021 |
Myrrhanone B and Myrrhanol B from resin of Commipohora mukul exhibit hepatoprotective effects in-vivo.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induce | 2021 |
Potential benefits of using hydrogen sulfide, vitamin E and necrostatin-1 to counteract acetaminophen‑induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2021 |
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2022 |
Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis.
Topics: Acetaminophen; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 2021 |
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Datasets as Topic; End | 2021 |
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Chrysanthem | 2021 |
Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product.
Topics: Acetaminophen; Adaptive Immunity; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line, | 2021 |
Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Non-Narcotic; Che | 2022 |
Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo and virtual screening.
Topics: Acetaminophen; Animals; Antioxidants; Aromatase; Chemical and Drug Induced Liver Injury; Disease Mod | 2021 |
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2021 |
Mass Spectrometry-Based Proteomics Reveal Alcohol Dehydrogenase 1B as a Blood Biomarker Candidate to Monitor Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Alcohol Dehydrogenase; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatogr | 2021 |
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fom | 2022 |
Effects of aqueous extract of Medicago denticulata against paracetamol-induced hepatotoxicity in rabbits.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Medicago; Plant Extrac | 2021 |
Oridonin Alters Hepatic Urea Cycle via Gut Microbiota and Protects against Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Bacteroides; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2021 |
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Kupffer Cells; Liver; M | 2022 |
APAP-Induced IκBβ/NFκB Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dilatation; I-kappa B Proteins; Inte | 2022 |
C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity.
Topics: Acetaminophen; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Humans | 2022 |
Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results w
Topics: Acetaminophen; Activation, Metabolic; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclophosp | 2022 |
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Inj | 2022 |
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Topics: Acetaminophen; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Citric Acid; Hep G2 Cells; | 2021 |
Extract of
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Chemical and | 2021 |
Network pharmacology, molecular docking technology integrated with pharmacodynamic study to reveal the potential targets of Schisandrol A in drug-induced liver injury by acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dose-Response Relation | 2022 |
Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eat | 2022 |
Application of the thick extract from Maitake mushrooms for correction of metabolic disorders under the paracetamol hepatitis in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Grifola; Hepatitis; Liver; Male; Met | 2021 |
Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biological Products; Chemical and Drug Induced Liver Injury | 2022 |
The dual role of immune response in acetaminophen hepatotoxicity: Natural products as immune interventions.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biological Products; Chemical and Drug Induced Liver Injury | 2022 |
Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Ca | 2022 |
Loss of hepatic miR-194 promotes liver regeneration and protects from acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Animals; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury; Ge | 2022 |
Questioning the RIPK1 kinase activity involvement in acetaminophen-induced hepatotoxicity in mouse.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Mice; Phosphorylation; Receptor-Inte | 2022 |
Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2022 |
Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical | 2022 |
Concurrent administration of acetaminophen and ethanol: impact on mouse liver and testis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Ethanol; Liver; Male; Mice; Testis | 2020 |
Authors' reply to Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eat | 2022 |
Serum iron concentrations in non-iron induced acute liver injury.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Drug Overd | 2022 |
Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical and Drug Indu | 2021 |
3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs.
Topics: Acetaminophen; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Chemical and Drug | 2022 |
Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Exosomes; Female; Freeze Drying; Hep | 2021 |
Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Administration, Oral; Animals; Binding Sites; Chemical and Drug Induced Liver Injury; | 2022 |
Large paracetamol overdose - Higher dose NAC is NOT required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2023 |
Endotoxin-Stimulated Hepatic Stellate Cells Augment Acetaminophen-Induced Hepatocyte Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Failure, Acute; | 2022 |
Large paracetamol overdose-Higher dose acetylcysteine is required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2023 |
PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; HEK293 Cel | 2022 |
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Ov | 2022 |
Comprehensive in vivo and in silico approaches to explore the hepatoprotective activity of poncirin against paracetamol toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Thromboelastography in the setting of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Blood Coagulation; Chemical and Drug Induced Liver Injury; Humans; International Norm | 2022 |
A ratiometric theranostic system for visualization of ONOO
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Per | 2022 |
The association between N-acetylcysteine treatment and hepatic healing in patients with non-acetaminophen-induced liver injury in pediatric intensive care: A single-center retrospective study.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 2022 |
Accidental intravenous acetaminophen overdose in an infant without development of hepatotoxicity: a case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2022 |
Drynaria quercifolia suppresses paracetamol‑induced hepatotoxicity in mice by inducing Nrf-2.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Plant Ext | 2022 |
The effect of nutritional status on the pharmacokinetic profile of acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diet, High-Fat; Fasting; Female; Mic | 2022 |
Hepatoprotective effect of Physalis divaricata in paracetamol induced hepatotoxicity: In vitro, in silico and in vivo analysis.
Topics: Acetaminophen; Animals; Biomarkers; Cell Proliferation; Chemical and Drug Induced Liver Injury; Dose | 2022 |
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Caspase 8; Caspase 9; Chemical and Dru | 2022 |
Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Charcoal; Chemical and Drug Induc | 2022 |
Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate acetaminophen-induced acute liver injury via p38 MAPK pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Humans | 2022 |
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury | 2022 |
The difference of chows affects mouse physiological conditions.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Li | 2022 |
Comment on "Thromboelastography in the setting of acetaminophen-induced hepatotoxicity".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Thrombelast | 2022 |
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Ameliorative effect of Spatoglossum asperum and its solvent fractions against acetaminophen-induced liver dysfunction in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Biomarkers; Caspase 3; Chemical and | 2022 |
Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways.
Topics: Acetaminophen; Animals; Anthraquinones; Caspase 1; Chemical and Drug Induced Liver Injury; Interleuk | 2022 |
Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocyte Growth Factor; Liver; Mes | 2022 |
Hepatic recruitment of eosinophils and their protective function during acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Eosinophils; Interleukin-33; Liver; | 2022 |
Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death.
Topics: Acetaminophen; Amygdalin; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Liver | 2022 |
Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Hepatocytes; Inflammatio | 2022 |
Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chron | 2022 |
Sinapic acid ameliorates paracetamol-induced acute liver injury through targeting oxidative stress and inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
[Atractylenolide Ⅰ improves acetaminophen-induced acute liver injury in mice by inhibiting MAPK/NF-κB signaling pathway].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lactones; Mice; NF-kappa B; Sesquite | 2022 |
Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Femal | 2022 |
FTY720 attenuates APAP‑induced liver injury via the JAK2/STAT3 signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Metabolite alteration analysis of acetaminophen-induced liver injury using a mass microscope.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chron | 2022 |
Temporal analysis of paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Thi | 2023 |
Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity.
Topics: Acetaminophen; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Phenacetin; Phospholipids | 2022 |
Ethnopharmacological impact of Melaleuca rugulosa (Link) Craven leaves extract on liver inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Kelch-Like ECH-Associated | 2022 |
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal.
Topics: Acetaminophen; Animals; Anthraquinones; Antioxidants; Chemical and Drug Induced Liver Injury; COVID- | 2022 |
Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glucosides; Liver Failur | 2022 |
Editorial for "Noninvasive Assessment of APAP-Induced Hepatotoxicity Using Multiple MR Parameters in an Experimental Rat Model".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Mice; Mice, Inbr | 2022 |
Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Cyclo | 2023 |
Noninvasive Assessment of APAP (N-acetyl-p-aminophenol)-Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Contrast Media; Diffusion Magnetic R | 2022 |
Treating acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug | 2022 |
6'-
Topics: Acetaminophen; Animals; Antioxidants; Arbutin; Caffeic Acids; Chemical and Drug Induced Liver Injury | 2022 |
Preclinical validation of silibinin/albumin nanoparticles as an applicable system against acute liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopol | 2022 |
Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways.
Topics: Acetaminophen; Animals; Antioxidants; Benzyl Alcohols; Chemical and Drug Induced Liver Injury; Chemi | 2022 |
Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte.
Topics: Acetaminophen; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Cyclooctanes; | 2022 |
Inhibition of NAD kinase elevates the hepatic NAD
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; NAD | 2022 |
Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemical and D | 2022 |
Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Databases, Factual; Fomepizol | 2022 |
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Ferulic acid ameliorates acetaminophen-induced acute liver injury by promoting AMPK-mediated protective autophagy.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Autophagy; Chemical and Drug Induced Liver In | 2022 |
Reply to: "Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis".
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chron | 2022 |
Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Inflammation; Mice; Mic | 2022 |
Failure of Risk Assessment After Paracetamol Overdose-A Short Communication.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2023 |
Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Mice; Spheroids | 2022 |
Protective Effects of Polydatin from Grapes and
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Glucosides; Macrophages; Reynoutria; Stilbene | 2022 |
Alterations in circadian rhythms aggravate Acetaminophen-induced liver injury in mice by influencing Acetaminophen metabolization and increasing intestinal permeability.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
The spatiotemporal program of zonal liver regeneration following acute injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatic Stellate Cells; Hepatocytes; | 2022 |
3,3',5-triiodo-l-thyronine inhibits drug-induced liver injury through activation of PPARα as revealed by network pharmacology and biological experimental verification.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Failure, Acute; Network | 2022 |
Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases.
Topics: Acetaminophen; Adolescent; Adult; Algorithms; Analgesics, Non-Narcotic; Chemical and Drug Induced Li | 2023 |
The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency.
Topics: Acetaminophen; Aldehyde Reductase; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liv | 2022 |
Effects of dietary restriction on hepatic sulfur-containing amino acid metabolism and its significance in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical and Drug Indu | 2022 |
Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Kelch-Like ECH-Associated Protein 1; | 2022 |
Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cinnamates; Depsides; Humans; Liver; | 2022 |
Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication.
Topics: Acetaminophen; Activins; Animals; Autophagy; Bone Morphogenetic Proteins; Chemical and Drug Induced | 2022 |
Co-Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver-Chip for the Study of Drug-Induced Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coculture Techniques; Hepatocytes; H | 2022 |
BML-257, a Small Molecule that Protects against Drug-Induced Liver Injury in Zebrafish.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Zebrafish | 2022 |
A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; bcl-2-Associated X Protein; Chemical and Drug Induced Liver In | 2022 |
Hepatoprotective Activity of
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Liver; Nelumbo; Oxidative Stress; Rea | 2022 |
Topics: Acetaminophen; Animals; Broussonetia; Chemical and Drug Induced Liver Injury; Chemical and Drug Indu | 2022 |
The hematological and histological studies for the hepatoprotective-like effect of the hydromethanolic extract and the fractions of Viola serpens Wall.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Phenols; Plant | 2022 |
The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Interferons; Intracellular Signaling | 2022 |
Tandem mass tag-based proteomics analysis reveals the effects of Guri Gumu-13 pill on drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Medicine, Chi | 2022 |
Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Compromised blood-bile barrier after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; D | 2022 |
Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endopeptidases; Kelch-Like ECH-Assoc | 2022 |
Inhibition of BTK improved APAP-induced liver injury via suppressing proinflammatory macrophages activation by restoring mitochondrion function.
Topics: Acetaminophen; Agammaglobulinaemia Tyrosine Kinase; Animals; Chemical and Drug Induced Liver Injury; | 2022 |
Liver Acinus Dynamic Chip for Assessment of Drug-Induced Zonal Hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Liver | 2022 |
Caveolin-1 Alleviates Acetaminophen-Induced Hepatotoxicity in Alcoholic Fatty Liver Disease by Regulating the Ang II/EGFR/ERK Axis.
Topics: Acetaminophen; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Caveolin 1; Chemical and Dr | 2022 |
Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Humans; In | 2022 |
Changes in Epidemiology of Acetaminophen Overdoses in an Urban County Hospital After 20 Years.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Overdose; Hos | 2022 |
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytoc | 2022 |
Diagnosis of drug-induced liver injury in model mice by studying the inhibitory effect of serum components on P450 inhibition assay.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome | 2022 |
Comment: Comparison of 2-Bag Versus 3-Bag
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 2023 |
Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; NAD; NF-E2-Related Fact | 2022 |
Possible Role of Extracellular Vesicles in Hepatotoxicity of Acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytochrome P | 2022 |
Protective Effect of Dandelion Leaf Water Extracts on APAP-Induced Liver Injury in Rats and Its Mechanism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Liver; NF-k | 2022 |
Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Anxiety Agents; Aspartate Aminotransferases; Bili | 2022 |
Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways.
Topics: Acetaminophen; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Aspartate Aminotransfer | 2022 |
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Inju | 2022 |
Diacerein protects liver against APAP-induced injury via targeting JNK and inhibiting JNK-mediated oxidative stress and apoptosis.
Topics: Acetaminophen; Animals; Anthraquinones; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical | 2022 |
Comment on accidental intravenous acetaminophen overdose in an infant without development of hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Infant | 2022 |
Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug | 2022 |
Genetic variants associated with ALT elevation from therapeutic acetaminophen.
Topics: Acetaminophen; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Drug Overdose; F | 2022 |
Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Topics: Acetaminophen; Animals; Arachidonate 5-Lipoxygenase; Bile Acids and Salts; Chemical and Drug Induced | 2023 |
Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfera | 2022 |
Development of a high-throughput micropatterned agarose scaffold for consistent and reproducible hPSC-derived liver organoids.
Topics: Acetaminophen; Cell Differentiation; Chemical and Drug Induced Liver Injury; Humans; Liver; Organoid | 2022 |
Sappanone A ameliorates acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases | 2022 |
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP | 2022 |
Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Necrosis; | 2023 |
Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation.
Topics: Acetaminophen; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Humans; Kaempferols; Li | 2022 |
Exploration of the Protective Mechanism of Naringin in the Acetaminophen-Induced Hepatic Injury by Metabolomics.
Topics: Acetaminophen; Amino Acids; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injur | 2022 |
[Preparation of salvianolic acid B, tanshinone Ⅱ_A, and glycyrrhetinic acid lipid emulsion and its protective effect against acute liver injury induced by acetaminophen].
Topics: Abietanes; Acetaminophen; Alanine Transaminase; Animals; Antipyretics; Aspartate Aminotransferases; | 2022 |
HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice.
Topics: Acetaminophen; Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Heat-Shock Protein | 2022 |
Nilotinib alleviated acetaminophen-induced acute hepatic injury in mice through inhibiting HIF-1alpha/VEGF-signaling pathway.
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Oxidat | 2022 |
GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study.
Topics: Acetaminophen; Alkaloids; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 2022 |
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Humans; Liver; Mice; Mic | 2022 |
Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrac | 2022 |
Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Chemical and Drug Induced Liver Injury | 2022 |
Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro.
Topics: Acetaminophen; Alanine; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Aspartate Amin | 2022 |
Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Fluorescent Dyes; Liver; M | 2022 |
The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Hepatoprotection by S-Adenosylmethionine in AML12 Cells.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inb | 2022 |
Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical | 2022 |
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Mice; | 2022 |
c-
Topics: Acetaminophen; Animals; Catalytic Domain; Chemical and Drug Induced Liver Injury; Glutamate-Cysteine | 2023 |
Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Acids; | 2023 |
Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drosophila; Glutathione; Liver; Mamm | 2022 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatocytes; Humans; Liver | 2023 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Drug-Related Side Effect | 2023 |
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Drug-Related Side Effect | 2023 |
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Drug-Related Side Effect | 2023 |
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Drug-Related Side Effect | 2023 |
Reply to Jaeschke and Ramachandran, "Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2023 |
Reply to Jaeschke and Ramachandran, "Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2023 |
Reply to Jaeschke and Ramachandran, "Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2023 |
Reply to Jaeschke and Ramachandran, "Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2023 |
Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 CYP2 | 2022 |
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Topics: Acetaminophen; Activating Transcription Factor 4; Chemical and Drug Induced Liver Injury; Humans; Li | 2023 |
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Transcriptional profiling of drug-induced liver injury biomarkers: association of hepatic Srebf1/Pparα signaling and crosstalk of thrombin, alcohol dehydrogenase, MDR and DNA damage regulators.
Topics: Acetaminophen; Alcohol Dehydrogenase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; D | 2023 |
Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperone BiP; | 2022 |
Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease.
Topics: Acetaminophen; Animals; Caveolin 1; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Mal | 2023 |
Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Macrophages; Membrane Glycopr | 2023 |
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Homeodomain Proteins; Inflammation; | 2023 |
Growth differentiation factor 15 is dispensable for acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction.
Topics: Acetaminophen; Ampicillin; Animals; Butyrates; Chemical and Drug Induced Liver Injury; Gastrointesti | 2023 |
Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Hepatocytes; Homeostasis; | 2023 |
The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats.
Topics: Acetaminophen; Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury; Chemical an | 2023 |
Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against Acetaminophen-Induced Acute Liver Injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Hydrogen Peroxide; Liv | 2023 |
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway.
Topics: Acetaminophen; Animals; Carrier Proteins; Caveolin 1; Chemical and Drug Induced Liver Injury; Inflam | 2023 |
Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Drug induced liver injury: causative agents and predictors for the outcome - a retrospective study at Tanta University Hospital, Egypt.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Egypt; End St | 2023 |
Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway and activating TLR4-NF-κB-MAPK inflammatory response in mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Inflammas | 2023 |
Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hepatocytes; JNK Mitoge | 2023 |
Semi-Targeted Profiling of Bile Acids by High-Resolution Mass Spectrometry in a Rat Model of Drug-Induced Liver Injury.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Glucuronides; | 2023 |
EGR1 is crucial for the chlorogenic acid-provided promotion on liver regeneration and repair after APAP-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina.
Topics: Acetaminophen; Animals; Animals, Genetically Modified; Antipyretics; Chemical and Drug Induced Liver | 2023 |
Confusoside from
Topics: Acetaminophen; Caspase 3; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Inflammation | 2023 |
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Curcuma; Heme Oxygenase-1; Liver; Mi | 2023 |
Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Ion Channels; Liver; Mi | 2023 |
Caesalpinia bonducella Counteracts Paracetamol-Instigated Hepatic Toxicity via Modulating TNF-α and IL-6/10 Expression and Bcl-2 and Caspase-8/3 Signalling.
Topics: Acetaminophen; Animals; Antioxidants; Caesalpinia; Caspase 3; Caspase 8; Chemical and Drug Induced L | 2023 |
Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Inflammation; Liver; NF- | 2023 |
Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Chemical and Drug Induced Liver I | 2023 |
Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug-Related Side E | 2023 |
Liver failure cases fall after US clampdown on paracetamol.
Topics: Accidental Falls; Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2023 |
Implementation of a pharmacist toxicology service on treatment of paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2023 |
Potential biomarkers and metabolomics of acetaminophen-induced liver injury during alcohol consumption: A preclinical investigation on C57/BL6 mice.
Topics: Acetaminophen; Alcohol Drinking; Amino Acids; Animals; Biomarkers; Chemical and Drug Induced Liver I | 2023 |
Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in rats.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Antioxidants; Chemical and Drug Induced Liver Injury | 2023 |
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver | 2023 |
Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2023 |
Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Hepatic C-X-C chemokine receptor type 6-expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Interleukin-17; Killer | 2023 |
Declining rates of opioid/acetaminophen combination product overdose: 2011-2020.
Topics: Acetaminophen; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Humans; Hydrocodone | 2023 |
Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway.
Topics: Acetaminophen; Animals; Bifidobacterium longum; Chemical and Drug Induced Liver Injury; Chemical and | 2023 |
Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats.
Topics: Acetaminophen; Agave; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Gum Arabic; Methan | 2023 |
Fisetin Attenuates Paracetamol-Induced Hepatotoxicity by Regulating CYP2E1 Enzyme.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E | 2023 |
Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Circulating Cell-Free DNAs as a Biomarker and Therapeutic Target for Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chemical and Drug Induce | 2023 |
Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure.
Topics: Acetaminophen; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Fibrin; | 2023 |
Comparative Effect of the Active Substance of Thyme with N-Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Bone Marrow; Chemical and Drug Induced Liver Injury; Liver; | 2023 |
Hepatoprotective activity of Balsamodendron mukul extract against Paracetamol-induced liver toxicity in rats: In vivo pharmacological and toxicological evaluation.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutamates; Liver; Pla | 2023 |
Association between adverse outcomes of hepatitis A and acetaminophen use: A population-based cohort study.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injur | 2023 |
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; beta-Galactosidase; Chemical and Drug Induced Liver Injury; Gastrointestinal | 2023 |
Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.
Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Chemical and Drug Induced Liver In | 2022 |
8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Liver; Meth | 2023 |
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Biomimetics; Chemical and Drug Induced Liver Injur | 2023 |
Endoplasmic Reticulum-Targeted Carbon Monoxide Photoreleaser for Drug-Induced Hepatotoxicity Remediation.
Topics: Acetaminophen; Animals; Carbon Monoxide; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul | 2023 |
Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury.
Topics: Acetaminophen; Antioxidants; Chemical and Drug Induced Liver Injury; Humans; Mitochondria; Oxidative | 2023 |
Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Leukocyte Elastase; Liver Diseases; | 2023 |
Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Failure, Acute; Male; M | 2023 |
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitro and in vivo experiments.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Investigation of the metabolomic crosstalk between liver sinusoidal endothelial cells and hepatocytes exposed to paracetamol using organ-on-chip technology.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hep G2 Cells; Hepatocytes; | 2023 |
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammasomes; Liver; Mice; Mice, In | 2023 |
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; COV | 2023 |
Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Mice; Molecular | 2023 |
Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS.
Topics: Acetaminophen; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Hepatocytes; H | 2023 |
Diagnostic potential of serum miR-532-3p as a circulating biomarker for experimental intrinsic drug-induced liver injury by acetaminophen and cisplatin in rats.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Circulating MicroRNA; Ci | 2023 |
Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2023 |
HClO imaging in vivo and drug-damaged liver tissues by a large Stokes shift fluorescent probe.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fluorescent | 2023 |
Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Glyco | 2023 |
The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats.
Topics: Acetaminophen; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Oxidants; O | 2023 |
Concurrent administration of farnesol protects acetaminophen-induced acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induce | 2023 |
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver | 2023 |
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipids; Liposomes; Liver; Liver Fail | 2023 |
Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Ethanol; Interleukin-6; Liver; Mice; | 2023 |
Protective Effect of Water-Soluble Acacetin Prodrug on APAP-Induced Acute Liver Injury Is Associated with Upregulation of PPARγ and Alleviation of ER Stress.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavones; Liver; Mice; Molecular Doc | 2023 |
Tangeretin and 4'-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Epigenesis, Genetic; H | 2023 |
New in vitro screening system to detect drug-induced liver injury using a culture plate with low drug sorption and high oxygen permeability.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Oxygen; Permeability; R | 2023 |
Neutrophils exacerbate acetaminophen-induced liver injury by producing cytotoxic interferon-γ.
Topics: Acetaminophen; Animals; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Chemical | 2023 |
Liver protective effect of chloroform extract of
Topics: Acetaminophen; Animals; Antioxidants; Bauhinia; Chemical and Drug Induced Liver Injury; Chloroform; | 2023 |
CXCL5 Promotes Acetaminophen-Induced Hepatotoxicity by Activating Kupffer Cells.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Kupffer Cells; Liver; M | 2023 |
Layer-by-layer reinforced-mediated sustained-release nanoantioxidants for long-lasting prevention against drug-induced liver injury.
Topics: Acetaminophen; Antioxidants; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Hu | 2023 |
A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb-Drug Interactions in Preventing Paracetamol-Induced Hepatotoxicity.
Topics: Acetaminophen; Antioxidants; Chemical and Drug Induced Liver Injury; Citrus; Herb-Drug Interactions; | 2023 |
Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Male; Mice; | 2023 |
A systems approach reveals species differences in hepatic stress response capacity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Mice; Oxidative Stres | 2023 |
Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. to evaluate its hepatoprotective activity.
Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Chemical and Drug Induced Liver Injury; Cymbopogon; | 2024 |
Caveolin-1 protects against liver damage exacerbated by acetaminophen in non-alcoholic fatty liver disease by inhibiting the ERK/HIF-1α pathway.
Topics: Acetaminophen; Animals; Caveolin 1; Chemical and Drug Induced Liver Injury; Hypoxia-Inducible Factor | 2023 |
Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Immunomodulatory Protective Effects of
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Creatine Kinase; Iron; Lactuca; Male | 2023 |
Wolfberry, Yam, and Chrysanthemum polysaccharides increased intestinal Akkermansia muciniphila abundance and hepatic YAP1 expression to alleviate DILI.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chrysanthemum; Dioscorea; Lipopolysa | 2023 |
Ethanol Extract of
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Chemi | 2023 |
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; DNA, Mitochondrial; Hesperidin; Humans; Liver | 2024 |
Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Antioxidants; Chemical and Drug Induced Liver | 2023 |
Antioxidative and Anti-Inflammatory Protective Effects of Fucoxanthin against Paracetamol-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2023 |
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.
Topics: Acetaminophen; Adult; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Inj | 2019 |
Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Cytochrome P | 2020 |
Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Caspase 3; | 2019 |
Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats.
Topics: Acetaminophen; Animals; Catechin; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sy | 2019 |
Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury.
Topics: Acetaminophen; Ammonia; Animals; Cattle; Cell Survival; Chemical and Drug Induced Liver Injury; Chon | 2019 |
Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Endocrine System; Female; H | 2020 |
Microsomal prostaglandin E synthase 2 deficiency is resistant to acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; | 2019 |
Consequences of analgesics use in early pregnancy: Results of tests on mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Ki | 2019 |
Protocol deviations in intravenous acetylcysteine therapy for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Live | 2020 |
CYP2E1 and miRNA-378a-3p contribute to acetaminophen- or tripterygium glycosides-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chlormethiazole; Cytochrome P-450 CY | 2020 |
Metformin ameliorates acetaminophen-induced sub-acute toxicity via antioxidant property.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Male; Metformin | 2022 |
CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization.
Topics: Acetaminophen; Animals; Cell Polarity; Chemical and Drug Induced Liver Injury; Chemokine CCL5; Disea | 2020 |
Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; Estrogen Rece | 2019 |
Effects of phenolic compounds from aqueous extract of Trifolium repens against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Glutathion | 2019 |
A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition.
Topics: Acetaminophen; Animals; Bupleurum; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-45 | 2019 |
Guanabenz Attenuates Acetaminophen-Induced Liver Toxicity and Synergizes Analgesia in Mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesia; Analgesics, Non-Narcotic; Animals; Chemical and Drug | 2020 |
Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell | 2020 |
TLR4 promotes liver inflammation by activating the JNK pathway.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemokine CCL2 | 2019 |
MRI-based preclinical discovery of DILI: A lesson from paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Chemical and | 2019 |
Red-Near-Infrared Fluorescent Probe for Time-Resolved in Vivo Alkaline Phosphatase Detection with the Assistance of a Photoresponsive Nanocontainer.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Benzopyrans; Cell Line, Tumor; Chemical and Drug Induc | 2019 |
Resveratrol Pretreatment Ameliorates p53-Bax Axis and Augments the Survival Biomarker B-Cell Lymphoma 2 Modulated by Paracetamol Overdose in a Rat Model of Acute Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Asp | 2020 |
Liver-specific Bid silencing inhibits APAP-induced cell death in mice.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist | 2019 |
5,7,3',4'-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical | 2019 |
[Acetaminophen poisonings hospitalized at the Pomeranian Center of Toxicology in 2010-2015].
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Chemical and Drug Induced Li | 2019 |
Auriculatone Sulfate Effectively Protects Mice Against Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines; | 2019 |
Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Coagulation; Blood Platelets; Chemical and D | 2020 |
Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacterial Translocation; Cell Membrane Permeabilit | 2020 |
Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Cytochrome | 2020 |
Suppression of acetaminophen-induced hepatocyte ultrastructural alterations in rats using a combination of resveratrol and quercetin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2019 |
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Topics: Acetaminophen; Adenosylhomocysteinase; Alanine Transaminase; Alcohol Dehydrogenase; Aldehyde Dehydro | 2020 |
Pelargonidin ameliorates acetaminophen-induced hepatotoxicity in mice by inhibiting the ROS-induced inflammatory apoptotic response.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthocyanins; Antioxidants; Apoptosis; Aspartate Amino | 2020 |
Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats.
Topics: Acetaminophen; Animals; Antioxidants; Cerium; Chemical and Drug Induced Liver Injury; Hep G2 Cells; | 2019 |
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.
Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury | 2020 |
Liver Transplantation for Acetaminophen-Induced Acute Liver Failure: Role of Psychiatric Comorbidity in Listing Decisions and Outcomes.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2020 |
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice.
Topics: Acetaminophen; Acute Lung Injury; Aminopyridines; AMP-Activated Protein Kinases; Animals; Cells, Cul | 2019 |
BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inh | 2020 |
Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents, Local | 2020 |
Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury.
Topics: Acetaminophen; Animals; Carboxylesterase; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu | 2019 |
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; | 2019 |
Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; | 2020 |
DNase γ-dependent DNA fragmentation causes karyolysis in necrotic hepatocyte.
Topics: Acetaminophen; Animals; Cell Death; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Endod | 2020 |
Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Ethanol; Fatty Acids, Nonesterified; | 2022 |
Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cynara scolymus; | 2020 |
Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Amin | 2020 |
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2020 |
Circulating microRNA Profiles in Acetaminophen Toxicity.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver In | 2020 |
Aged Citrus Peel (Chenpi) Prevents Acetaminophen-Induced Hepatotoxicity by Epigenetically Regulating Nrf2 Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Citrus; Drugs, Chinese Herbal; Flavo | 2019 |
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Overdos | 2020 |
Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Cynara scolymus | 2020 |
The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity.
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Animals; Chemical and Drug Induced Liver Injury | 2019 |
Visualization of Dynamic Changes in Labile Iron(II) Pools in Endoplasmic Reticulum Stress-Mediated Drug-Induced Liver Injury.
Topics: Acetaminophen; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Disease Models, Animal; E | 2020 |
Alcohol consumption is associated with the severity and outcome of acute liver injury/failure.
Topics: Acetaminophen; Aged; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Humans; Liver Failure | 2020 |
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver In | 2020 |
Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis.
Topics: Acetaminophen; Animals; Antibodies; Chemical and Drug Induced Liver Injury; HEK293 Cells; Homeostasi | 2020 |
Ccrn4l as a pre-dose marker for prediction of cisplatin-induced hepatotoxicity susceptibility.
Topics: Acetaminophen; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cisplatin; | 2020 |
Letter to the Editor Regarding the Article "Chrysin Effect in Prevention of Acetaminophen-Induced Hepatotoxicity in Rat" by Mohammadi and Co-Workers (2019).
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2020 |
Lophenol and lathosterol from resin of Commiphora kua possess hepatoprotective effects in vivo.
Topics: Acetaminophen; Animals; Catalase; Chemical and Drug Induced Liver Injury; Cholestenes; Cholesterol; | 2020 |
Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges.
Topics: Acetaminophen; Adolescent; Adult; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Dogs; | 2020 |
c-Jun NH
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Chemical and Drug Induced Liver Injur | 2020 |
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice.
Topics: Acetaminophen; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; bcl-2-Associated X Prote | 2020 |
The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Basic-Leucine Zipper Transcription | 2020 |
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes.
Topics: Acetaminophen; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2 | 2020 |
Network pharmacology based investigation into the bioactive compounds and molecular mechanisms of Schisandrae Chinensis Fructus against drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Drugs, Chine | 2020 |
Response to the Letter to the Editor by Hartmut Jaeschke and Anup Ramachandran Concerning Our Article "Chrysin Effect in Prevention of Acetaminophen-Induced Hepatotoxicity in Rat".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Rats | 2020 |
The concentration of tumor necrosis factor-α determines its protective or damaging effect on liver injury by regulating Yap activity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Animals, Genetically Modified; Apoptosis Regulatory Pr | 2020 |
Evaluating lactate prognostic value in children suspected of acetaminophen-induced liver failure in Liberia.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Hospital Mor | 2020 |
Hepatoprotective Effect of Neoagarooligosaccharide via Activation of Nrf2 and Enhanced Antioxidant Efficacy.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2020 |
Acetaminophen-induced hepatotoxicity of cultured hepatocytes depends on timing of isolation from light-cycle controlled mice.
Topics: Acetaminophen; Animals; Cell Separation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Ci | 2020 |
Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver | 2022 |
Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1
Topics: Acetaminophen; Cell Line; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Ge | 2020 |
Activation of Farnesoid X Receptor by Schaftoside Ameliorates Acetaminophen-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammation.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glycosides; Inflammati | 2020 |
Hepatoprotective effect of allicin against acetaminophen-induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Asp | 2020 |
Comparison of liver regeneration after partial hepatectomy and acetaminophen-induced acute liver failure: A global picture based on transcriptome analysis.
Topics: Acetaminophen; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Epidermal Growth | 2020 |
Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats: Targeting oxidative stress, STAT3, and apoptosis signals.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Apigenin; Apop | 2020 |
Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, L | 2020 |
The c-Met inhibitor capmatinib alleviates acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Benzamides; Chemical and Drug Induced Liver Injury | 2020 |
Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2020 |
Hepatoprotective Effect of
Topics: Acetaminophen; Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; | 2020 |
Upregulation of Nrf2-related cytoprotective genes expression by acetaminophen-induced acute hepatotoxicity in mice and the protective role of betaine.
Topics: Acetaminophen; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Betaine; Chem | 2020 |
The MicroRNA-based Liquid Biopsy Improves Early Assessment of Lethal Acetaminophen Poisoning: A Case Report.
Topics: Acetaminophen; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Fatal Outco | 2020 |
Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver.
Topics: Acetaminophen; Adult; Age Factors; Animals; Chemical and Drug Induced Liver Injury; Child; Cytochrom | 2020 |
Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Cell Survival; Cells, Cultu | 2020 |
Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Coculture | 2020 |
Public awareness of acetaminophen and risks of drug induced liver injury: Results of a large outpatient clinic survey.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Awareness; Ca | 2020 |
Risk Factors for Acetaminophen-induced Liver Injury: A Single-center Study from Japan.
Topics: Acetaminophen; Aged; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Antipyret | 2020 |
Alternatively activated macrophages promote resolution of necrosis following acute liver injury.
Topics: Acetaminophen; Animals; Cell- and Tissue-Based Therapy; Chemical and Drug Induced Liver Injury; Cyto | 2020 |
Peroxiredoxin 6 mediates acetaminophen-induced hepatocyte death through JNK activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; JNK Mitogen-Activated P | 2020 |
Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway.
Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Model | 2020 |
Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Europe; He | 2020 |
Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model.
Topics: Acetaminophen; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Disease Models, Animal; L | 2020 |
The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Capillaries; Cell Line; Cell Line, Tumor; Chemical and | 2020 |
New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis.
Topics: Acetaminophen; Adaptor Proteins, Vesicular Transport; Cell Line; Cell Line, Tumor; Cells, Cultured; | 2020 |
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Do | 2020 |
Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Diagnosis, Differential; Female; Foren | 2020 |
Acetaminophen-induced hepatotoxicity: different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Ferroptosi | 2020 |
Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization.
Topics: Acetaminophen; Alanine Transaminase; Aldehyde Dehydrogenase, Mitochondrial; Analgesics, Non-Narcotic | 2020 |
Role of cinnamon oil against acetaminophen overdose induced neurological aberrations through brain stress and cytokine upregulation in rat brain.
Topics: Acetaminophen; Acetylcholinesterase; Animals; Antioxidants; Brain; Chemical and Drug Induced Liver I | 2022 |
Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Platelets; Cell Membrane Permeability; Cell Res | 2020 |
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Case-Control Studies; Cell-Free Nucleic Acids; Che | 2020 |
Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Limonins; Liver; Male; | 2020 |
[Study on protective effect of water extract from Sabia parviflora on liver injury in mice induced by acetaminophen].
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2020 |
Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cell Culture Techniques; Cells, Cultured; Chemical and Drug | 2020 |
Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2020 |
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.
Topics: Acetaminophen; Animals; Blood Platelets; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 2020 |
Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Basic-Leucine Zipper Transcription Factors; Cell N | 2020 |
Real-time monitoring and accurate diagnosis of drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite.
Topics: Acetaminophen; Animals; Carbocyanines; Chemical and Drug Induced Liver Injury; Female; Fluorescence | 2020 |
Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Female; Fla | 2020 |
PiTMaP: A New Analytical Platform for High-Throughput Direct Metabolome Analysis by Probe Electrospray Ionization/Tandem Mass Spectrometry Using an R Software-Based Data Pipeline.
Topics: Acetaminophen; Animals; Brain; Chemical and Drug Induced Liver Injury; Discriminant Analysis; High-T | 2020 |
Murine iNKT cells are depleted by liver damage via activation of P2RX7.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2020 |
Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Disease M | 2020 |
Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomar | 2020 |
Prolonged neutrophil survival at necrotic sites is a fundamental feature for tissue recovery and resolution of hepatic inflammation.
Topics: Acetaminophen; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Female; Liver; Mice; | 2020 |
Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Genistein; | 2020 |
Improvement of therapeutic potential N-acetylcysteine in acetaminophen hepatotoxicity by encapsulation in PEGylated nano-niosomes.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; C | 2020 |
Mechanism-based identification of plasma metabolites associated with liver toxicity.
Topics: Acetaminophen; Animals; Biomarkers; Bromobenzenes; Chemical and Drug Induced Liver Injury; Gene Expr | 2020 |
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Co | 2020 |
Patterns of transaminase elevation in rhabdomyolysis versus acetaminophen toxicity.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Diagnosis, Diff | 2021 |
Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2020 |
ORY supplementation mitigates acetaminophen-induced acute liver failure in male mice: role of oxidative stress and apoptotic markers.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug In | 2020 |
Chlorogenic acid alleviates acetaminophen-induced liver injury in mice via regulating Nrf2-mediated HSP60-initiated liver inflammation.
Topics: Acetaminophen; Animals; Chaperonin 60; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Dis | 2020 |
Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Res | 2020 |
Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound.
Topics: Acetaminophen; Cell Death; Chemical and Drug Induced Liver Injury; Drug Synergism; Ficusin; Hep G2 C | 2020 |
Isatidis Folium alleviates acetaminophen-induced liver injury in mice by enhancing the endogenous antioxidant system.
Topics: Acetaminophen; Animals; Antioxidants; Benzoquinones; Chemical and Drug Induced Liver Injury; Chemica | 2020 |
Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2020 |
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Cytochrome P-450 CYP2E1; | 2020 |
Assessment of antioxidant traits and protective action of Egyptian acacia pods extracts against paracetamol-induced liver toxicity in rats.
Topics: Acacia; Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Egypt; Plant E | 2020 |
Late Diagnosis of Paracetamol Poisoning is Always Lethal in Young Adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Del | 2020 |
Multiomics Profiling Reveals Protective Function of
Topics: Acetaminophen; Administration, Oral; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2020 |
Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery During Acetaminophen Hepatotoxicity.
Topics: Acetaminophen; Blood Platelets; Cell Death; Chemical and Drug Induced Liver Injury; Humans; Lectins, | 2020 |
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
Topics: Abietanes; Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, Subfa | 2020 |
LncRNA KCNQ1OT1 ameliorates the liver injury induced by acetaminophen through the regulation of miR-122-5p/CES2 axis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Carboxylesterase; Cell Line, Tumor; Che | 2020 |
Kaempferol from
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liv | 2020 |
Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Alkaline Phosphatase; Animals; Chemi | 2020 |
Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Kidney; Liver; Male; Oxidative Stres | 2021 |
Capsaicin alleviates acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Analgesics; Animals; Capsaicin; Chemical and Drug Induced Liver Injury; Cytokines; HM | 2020 |
Hepatoprotective Activity of Yellow Chinese Chive against Acetaminophen-Induced Acute Liver Injury via Nrf2 Signaling Pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chive; Glutathione; Heme Oxygenase ( | 2020 |
Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Humans; Iron; Male; Mice; Mi | 2020 |
Guavinoside B from
Topics: Acetaminophen; Animals; Benzophenones; Chemical and Drug Induced Liver Injury; Fruit; Hepatocytes; H | 2020 |
Hepatoprotective effect of Omega-3 PUFAs against acute paracetamol-induced hepatic injury confirmed by FTIR.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2021 |
Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Basic Helix-Loop-Helix Transcription Factors; Chemical and Drug Induced Live | 2021 |
Orostachys japonicus ameliorates acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Crassulaceae; Dose-Response Relation | 2021 |
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; | 2021 |
Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in rat liver and kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Inju | 2021 |
Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Am | 2021 |
Dibenzazepine combats acute liver injury in rats via amendments of Notch signaling and activation of autophagy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; | 2021 |
A general model for cell death and biomarker release from injured tissues.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Animals; Aspartate Aminotransfe | 2021 |
The cross-talk of NLRP3 inflammasome activation and necroptotic hepatocyte death in acetaminophen-induced mice acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Hepatocyte | 2021 |
Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury.
Topics: Acetaminophen; Adenosine Triphosphate; Albumins; Animals; Arabinofuranosyluracil; Chemical and Drug | 2021 |
Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Fu | 2020 |
Estrogen receptor agonists protect against acetaminophen-induced hepatorenal toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2020 |
The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Gene | 2021 |
Protective mechanisms of piperine against acetaminophen-induced hepatotoxicity may be mediated through TGFBRAP1.
Topics: Acetaminophen; Alkaloids; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Antioxidants; | 2020 |
Visualization of ONOO
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; Fluorescent Dyes | 2020 |
Hypothermia Advocates Functional Mitochondria and Alleviates Oxidative Stress to Combat Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Chemical and Drug Induced Li | 2020 |
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Carcinogenicity Tests; Cell Death; Chemical a | 2020 |
4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Live | 2020 |
Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats.
Topics: Acetaminophen; Acute Disease; Amino Acids; Animals; Biomarkers; Bromobenzenes; Carbon Tetrachloride; | 2020 |
circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Proliferation; Chemical and Drug Induced Live | 2020 |
Optimizing Acetaminophen Use in Patients with Risk Factors for Hepatotoxicity: Reviewing Dosing Recommendations in Adults.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Live | 2021 |
Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2021 |
Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2021 |
Preparation and antihepatotoxicity activity of Fagonia indica extract and its solid dispersion formulation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dosage Forms | 2020 |
Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; D | 2021 |
Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2020 |
MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Survival; Chemical and Drug Induce | 2021 |
Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.
Topics: Acetaminophen; Adoptive Transfer; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liv | 2020 |
Antidiabetic and hepatoprotective potential of whole plant extract and isolated compounds of Aeginetia indica.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Diabetes M | 2020 |
Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury.
Topics: Acetaminophen; Adult; Age Factors; Antibodies, Viral; Biopsy; Chemical and Drug Induced Liver Injury | 2020 |
Macrophage-Inducible C-Type Lectin Signaling Exacerbates Acetaminophen-Induced Liver Injury by Promoting Kupffer Cell Activation in Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Express | 2021 |
CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Male; Mice | 2021 |
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Topics: Acetaminophen; Animals; Benzoquinones; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyto | 2021 |
Acute Liver Injury With Therapeutic Doses of Acetaminophen: A Prospective Study.
Topics: Acetaminophen; Adult; Age Factors; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Ind | 2021 |
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury.
Topics: Acetaminophen; Adult; Animals; Bacteria; Bacterial Infections; Chemical and Drug Induced Liver Injur | 2021 |
The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model.
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced L | 2021 |
A computational model of liver tissue damage and repair.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Prolifera | 2020 |
Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Aporphines; Chemical and Drug Induced Liver Injury; Cytokine | 2021 |
Sleep disorders are associated with acetaminophen-induced adverse reactions and liver injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cro | 2021 |
Hepatoprotective effect of
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2021 |
A network pharmacology-integrated metabolomics strategy for clarifying the action mechanisms of Schisandrae Chinensis Fructus for treating drug-induced liver injury by acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dr | 2021 |
Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Membrane Potential, Mit | 2021 |
A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2021 |
Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Liver; Male; Oxidative S | 2021 |
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Cell Death; Chemical and Drug Induced L | 2021 |
Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Hu | 2021 |
Does acetaminophen hepatotoxicity involve apoptosis, inflammatory liver injury, and lipid peroxidation?
Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Lipid Peroxidation; Liver; | 2021 |
Predicting mortality from acetaminophen poisoning shortly after hospital presentation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdo | 2021 |
Hepatoprotective effect of forsythiaside a against acetaminophen-induced liver injury in zebrafish: Coupling network pharmacology with biochemical pharmacology.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and D | 2021 |
N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer - a case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug In | 2021 |
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury | 2021 |
Aedes aegypti mosquito saliva ameliorates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Aedes; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytochr | 2021 |
Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced | 2021 |
Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Ethanol; Fasting; Humans | 2021 |
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Topics: Acetaminophen; Animals; Animals, Genetically Modified; Chemical and Drug Induced Liver Injury; Fruit | 2021 |
Plasma miR-218a-5p as a biomarker for acute cholestatic liver injury in rats and investigation of its pathophysiological roles.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Disease Mod | 2021 |
Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Coagulation; Chemical and Drug Induced Liver | 2021 |
Exogenous activation of toll-like receptor 5 signaling mitigates acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Down-Regulation; Flagellin; Gene Exp | 2021 |
Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cardiotoxicity; Chemical and Drug Induced Liver In | 2021 |
Hepatoprotective and antioxidant activity of Dicliptera bupleuroides Nees. extracts on paracetamol induced hepatotoxicity in rats.
Topics: Acanthaceae; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Carbon Tetrachloride; C | 2020 |
Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and | 2021 |
Role of gambogenic acid in regulating PI3K/Akt/NF-kβ signaling pathways in rat model of acute hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver; Male; | 2021 |
Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Differentiation; Chemical and Drug Induced Li | 2020 |
Letter to the Editor: Acute Liver Injury Due to Therapeutic Doses of Acetaminophen-Confounders Must Be Ruled Out!
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver | 2021 |
Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Coagulation Disorders; Chemical and Drug Induced Liver | 2021 |
Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study.
Topics: Acetaminophen; Acute Kidney Injury; Administration, Intravenous; Birth Weight; Chemical and Drug Ind | 2021 |
Protective effect of Que Zui tea hot-water and aqueous ethanol extract against acetaminophen-induced liver injury in mice via inhibition of oxidative stress, inflammation, and apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; In | 2021 |
Protective Effect of Dihydrokaempferol on Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway.
Topics: Acetaminophen; Alanine Transaminase; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransfer | 2021 |
FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Deoxycholic Acid; Hepatocytes; Liver | 2021 |
Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways.
Topics: Acetaminophen; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Endothelial Cells; He | 2021 |
Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antibodies, Monoclonal; Chemical and Drug Induced | 2022 |
Dehydroepiandrosterone protects against acetaminophen-induced liver damage in rats by upregulation of Bcl-2 and activation of sirt signalling.
Topics: Acetaminophen; Animals; Carbazoles; Chemical and Drug Induced Liver Injury; Dehydroepiandrosterone; | 2020 |
Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2021 |
Bioactive compounds and hepatoprotective effect of
Topics: Acetaminophen; Animals; Antioxidants; Apocynaceae; Chemical and Drug Induced Liver Injury; Fruit and | 2022 |
Effect of betulinic acid administration on TLR-9/NF-κB /IL-18 levels in experimental liver injury
Topics: Acetaminophen; Animals; Betulinic Acid; Chemical and Drug Induced Liver Injury; Interleukin-18; Live | 2021 |
Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced | 2021 |
Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; | 2021 |
Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Factor XII; Female; Fibrinolysin; Fi | 2021 |
Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Necrosis; Oxida | 2022 |
Hepatoprotective effect of Ziziphus oxyphylla Edgew in paracetamol-induced hepatotoxic rat model.
Topics: Acetaminophen; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Mo | 2020 |
Changes in the proteome of extracellular vesicles shed by rat liver after subtoxic exposure to acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Extracellular Vesicles; Hepatocytes; | 2021 |
A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Case-Control Studies; Chemical and Drug | 2021 |
Can granulocyte colony stimulating factor (G-CSF) ameliorate acetaminophen-induced hepatotoxicity?
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; | 2021 |
Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used?
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2021 |
Interleukin 33 mediates hepatocyte autophagy and innate immune response in the early phase of acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Line, Tumor; Cell Survival; Chemical and Drug | 2021 |
Analysis of the Australia and New Zealand referral criteria for transfer to a liver unit for paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Ove | 2021 |
Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; H | 2021 |
An artificial intelligence algorithm for analyzing acetaminophen-associated toxic hepatitis.
Topics: Acetaminophen; Adult; Algorithms; Artificial Intelligence; Chemical and Drug Induced Liver Injury; C | 2021 |
HEPATOPROTECTIVE EFFICIENCY OF G10 SUBSTANCE FROM ZHUZGUN PLANT IN EXPERIMENTAL TOXIC HEPATITIS.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Plant Extracts; Rats; Rats, W | 2021 |
Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Crystallography, X-Ray; Cullin Prote | 2021 |
Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hepatocytes; Humans; Li | 2021 |
Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion.
Topics: Acetaminophen; Animals; Animals, Genetically Modified; Blood Circulation; Carbon Tetrachloride; Cart | 2021 |
Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdo | 2022 |
Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Gene Silencing; Hepatocy | 2021 |
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetaminophen; Animals; Chemical and Drug Induced Liv | 2021 |
The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Glutathion | 2021 |
Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice.
Topics: Acetaminophen; Animals; Camellia; Chemical and Drug Induced Liver Injury; Liver Failure, Acute; Mice | 2021 |
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2021 |
Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.
Topics: Acetaminophen; Acyclic Monoterpenes; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspart | 2021 |
Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Chemical and Drug Ind | 2021 |
Extremely Elevated Procalcitonin in a Case of Acetaminophen Overdose and Acute Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2022 |
Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Ch | 2021 |
Rodenticide ingestion is an important cause of acute hepatotoxicity in Tamil Nadu, southern India.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum | 2021 |
Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Kelch-Like ECH-Associa | 2021 |
AST/ALT levels, MDA, and liver histopathology of
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; | 2021 |
Modulation of NRF2/ARE pathway- and cell death-related genes during drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Inj | 2021 |
Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Development; Humans; Liver; Mic | 2021 |
Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dioxygenases; Hepatocytes; Iron; Liv | 2021 |
Drug-induced liver injury in Australia, 2009-2020: the increasing proportion of non-paracetamol cases linked with herbal and dietary supplements.
Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Antineoplastic Agents; Antipyretics; Antitubercular Age | 2021 |
Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Coho | 2021 |
Protective effect of Heliotropium strigosum 70% aqueous methanolic extract against paracetamol induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2021 |
Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Inflammation | 2021 |
RIP1 kinase inactivation protects against acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Liver Failure, A | 2021 |
Eight-Fold Increase in Dietary Supplement-Related Liver Failure Leading to Transplant Waitlisting Over the Last Quarter Century in the United States.
Topics: Acetaminophen; Acute-On-Chronic Liver Failure; Chemical and Drug Induced Liver Injury; Child; Dietar | 2022 |
Alterations of Cytochrome P450-Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Topics: Acatalasia; Acetaminophen; Animals; Catalase; Chemical and Drug Induced Liver Injury; Gene Expressio | 2021 |
Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Chemical and D | 2021 |
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cardiolipins; Ceramides; Chemical and Drug Induced | 2022 |
Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2022 |
Omega‑3 polyunsaturated fatty acids inhibit IL‑11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fatty Acids, Omega-3; Hepatocytes; I | 2021 |
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liv | 2021 |
Investigating acetaminophen hepatotoxicity in multi-cellular organotypic liver models.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2017 |
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Topics: Acetaminophen; Albumins; Animals; Bile; Chemical and Drug Induced Liver Injury; Dogs; Female; Hepato | 2017 |
Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury.
Topics: Acetaminophen; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Coordination Complexes; D | 2017 |
Protective Effect of Cymbopogon citratus Essential Oil in Experimental Model of Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Chemical and Drug Induced Liver Inju | 2017 |
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.
Topics: Acetaminophen; Acute-On-Chronic Liver Failure; Adaptive Immunity; Adult; Animals; Antibodies; B7-1 A | 2017 |
Multi-targeted protection of acetaminophen-induced hepatotoxicity in mice by tannic acid.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotr | 2017 |
Hepatotoxicity of paracetamol and related fatalities.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Failu | 2017 |
Development and validation of a dynamic outcome prediction model for paracetamol-induced acute liver failure: a cohort study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Chemical and Drug Induced Liver In | 2016 |
Glutathione S-transferase A1 (GSTA1) as a marker of acetaminophen-induced hepatocyte injury in vitro.
Topics: Acetaminophen; Animals; Biomarkers; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease | 2017 |
Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcot | 2017 |
Saponins (Ginsenosides) from the Leaves of Panax quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and D | 2017 |
Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2017 |
Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Li | 2017 |
[EFFECT OF ACETYLCYSTEINE, CORVITIN AND THEIR COMBINATION ON THE FUNCTIONAL STATE OF LIVER IN RATS WITH PARACETAMOL INDUCED TOXIC HEPATITIS].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver In | 2017 |
CXCL16 deficiency attenuates acetaminophen-induced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemokine | 2017 |
Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound.
Topics: Acetaminophen; Adenosine Triphosphate; Albumins; Animals; Chemical and Drug Induced Liver Injury; Li | 2017 |
Anti-oxidative and anti-inflammatory benefits of the ribonucleoside analogue 5-azacitidine in mice with acetaminophen-induced toxic hepatitis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Azacitidine; Chemical and Drug Induc | 2017 |
Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Inflammation | 2018 |
Methanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; C | 2017 |
Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Catalase; Cell | 2017 |
Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2017 |
Effects of rosmarinic acid on acetaminophen-induced hepatotoxicity in male Wistar rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxida | 2017 |
Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Diet, High-Fat; Endothe | 2017 |
PROTECTIVE EFFECT OF
Topics: Acetaminophen; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; DNA Fragment | 2017 |
Hepatoprotective and antioxidant activity of quercetin loaded chitosan/alginate particles in vitro and in vivo in a model of paracetamol-induced toxicity.
Topics: Acetaminophen; Alginates; Animals; Antioxidants; Cell Survival; Chemical and Drug Induced Liver Inju | 2017 |
Synergistic protective effect of picrorhiza with honey in acetaminophen induced hepatic injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Cell Survival | 2016 |
Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Basic Helix-Loop-Helix Transcription Factors; Chem | 2017 |
FGF21 functions as a sensitive biomarker of APAP-treated patients and mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2017 |
Acetylcysteine (Cetylev) for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antioxidants; Chemica | 2017 |
Bayesian Forecasting Tool to Predict the Need for Antidote in Acute Acetaminophen Overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Baye | 2017 |
Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2017 |
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Ove | 2017 |
Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Delivery Systems; Hepatocytes; | 2017 |
Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2).
Topics: Acetaminophen; Acetylcysteine; Adult; Australia; Charcoal; Chemical and Drug Induced Liver Injury; D | 2017 |
Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biological Assay; Cell Differentiation; Cell Survival; Chem | 2017 |
The role of MAP2 kinases and p38 kinase in acute murine liver injury models.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Knockdown Techni | 2017 |
Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical and Drug Induced Liver I | 2017 |
Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Female; Glutathione P | 2017 |
Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.
Topics: Acetaminophen; Adult; Base Sequence; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liv | 2017 |
Restorative effects of Chrysin pretreatment on oxidant-antioxidant status, inflammatory cytokine production, and apoptotic and autophagic markers in acute paracetamol-induced hepatotoxicity in rats: An experimental and biochemical study.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Apoptosis; Autophagy; Biomarkers; Chemic | 2017 |
Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Cell | 2017 |
Hepatoprotective effects of ethanol extracts from Folium Syringae against acetaminophen-induced hepatotoxicity in vitro and in vivo.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Glutathione | 2017 |
Mechanisms of sterile inflammation in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Macrophages; Mice | 2018 |
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.
Topics: Acetaminophen; Animals; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Liver; | 2017 |
Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induce | 2017 |
Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bilirubin; Biomarkers; Cell Survival; | 2017 |
Liquid chromatography mass spectrometry-based profiling of phosphatidylcholine and phosphatidylethanolamine in the plasma and liver of acetaminophen-induced liver injured mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Choline Kinase; Chromatography, Liqu | 2017 |
Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced | 2018 |
Increased acetaminophen related calls to Finnish PIC better reflect acetaminophen sales than serious poisonings.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Commerce; Dru | 2018 |
The use of sustained low efficiency dialysis (SLED) in massive paracetamol overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; D | 2018 |
Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; DNA, Mitoc | 2017 |
Silver nanoparticles protect acetaminophen induced acute hepatotoxicity: A biochemical and histopathological approach.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2017 |
Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs.
Topics: Acetaminophen; Animals; Biomarkers; Blood Cell Count; Blood Coagulation; Blood Coagulation Factors; | 2017 |
Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hexuronic Acids; Humans; Male; Mice, | 2017 |
Protective effect and mechanism of action of diallyl disulfide against acetaminophen-induced acute hepatotoxicity.
Topics: Acetaminophen; Allyl Compounds; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochro | 2017 |
Psychosocial and behavioral factors in acetaminophen-related acute liver failure and liver injury.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Liver F | 2017 |
Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fibroblast Growth Factors; Hepatocyt | 2018 |
Erythropoietin enhances Kupffer cell number and activity in the challenged liver.
Topics: Acetaminophen; Animals; Antigens, Ly; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced | 2017 |
Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP | 2017 |
[3D evaluation model for drug hepatotoxicity testing on HepG2 cells and its application in drug safety evaluation].
Topics: Acetaminophen; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Hepato | 2016 |
Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
Topics: Acetaminophen; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Flavonoids; | 2017 |
Eight new phenylethanoid glycoside derivatives possessing potential hepatoprotective activities from the fruits of Forsythia suspensa.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Forsythia; Fruit; Glycosides; Hep G2 Cells; H | 2017 |
Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Chemical and Drug Induced Liver | 2017 |
Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice.
Topics: Acetaminophen; Animals; Apolipoprotein A-I; Chemical and Drug Induced Liver Injury; Fibroblast Growt | 2017 |
Celastrol ameliorates acetaminophen-induced oxidative stress and cytotoxicity in HepG2 cells.
Topics: Acetaminophen; Antioxidants; Catalase; Cell Survival; Chemical and Drug Induced Liver Injury; Glutat | 2018 |
Extract from Mulberry (Morus australis) leaf decelerate acetaminophen induced hepatic inflammation involving downregulation of myeloid differentiation factor 88 (MyD88) signals.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Down-Regulation; Humans; Liver; Male | 2017 |
Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Carrageenan; Chemical and D | 2017 |
IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bone Marrow Transplantation; Chemical and Drug Ind | 2018 |
Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cell Line; Chemical and Drug Induced Liver | 2017 |
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
Topics: Acetaminophen; Alarmins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Huma | 2017 |
The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2017 |
Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antiox | 2017 |
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans.
Topics: Acetaminophen; Cell Line; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Female; HEK2 | 2018 |
Therapeutic dose of green tea extract provokes liver damage and exacerbates paracetamol-induced hepatotoxicity in rats through oxidative stress and caspase 3-dependent apoptosis.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; | 2017 |
Hepatoprotective activity and phenolic profile of Zanthoxylum alatum Roxb. fruit extract.
Topics: Acetaminophen; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatogr | 2017 |
Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics.
Topics: Acetaminophen; Animals; Antioxidants; Caffeine; Chemical and Drug Induced Liver Injury; Energy Metab | 2018 |
A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Cell Movement; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chem | 2017 |
Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Cell Survival; Chemical and Drug Induced Liver Inju | 2018 |
Biomarkers for risk assessment in paracetamol hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; | 2018 |
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; | 2018 |
Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Body Mass Index; Chemical and Drug Induced Liver I | 2018 |
IL-1α in acetaminophen toxicity: a sterile danger signal.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Interleukin-1alpha; Ma | 2018 |
Tethering Interleukin-22 to Apolipoprotein A-I Ameliorates Mice from Acetaminophen-induced Liver Injury.
Topics: Acetaminophen; Animals; Apolipoprotein A-I; Chemical and Drug Induced Liver Injury; Extracellular Si | 2017 |
Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2017 |
Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2017 |
Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2018 |
Spondias mombin L. (Anacardiaceae) enhances detoxification of hepatic and macromolecular oxidants in acetaminophen-intoxicated rats.
Topics: Acetaminophen; Anacardiaceae; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytopro | 2017 |
Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2017 |
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome | 2017 |
Intravenous
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Chemical and Drug Induced Liv | 2017 |
Lysophosphatidic acid protects against acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Gene Expression Regulatio | 2017 |
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Over | 2018 |
Chemical characterisation and hepatoprotective potential of Cosmos sulphureus Cav. and Cosmos bipinnatus Cav.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Chemical and Drug Induced Liver Injury; Hepatocyte | 2019 |
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Topics: Acetaminophen; Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Disease Models, A | 2017 |
Kaurenoic acid extracted from Sphagneticola trilobata reduces acetaminophen-induced hepatotoxicity through inhibition of oxidative stress and pro-inflammatory cytokine production in mice.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Brazil; Chemical and Drug Induced Liver Injury; Di | 2019 |
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Autophagy-Related Protein-1 Homolog; | 2018 |
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
Topics: Acetaminophen; Acidosis, Lactic; Adult; Blood Coagulation Disorders; Chemical and Drug Induced Liver | 2018 |
The effects of apomorphine on paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apomorphine; Aspartate Aminotransferases | 2017 |
[Adverse Event Trends Associated with Over-the-counter Combination Cold Remedy: Data Mining of the Japanese Adverse Drug Event Report Database].
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Biliary Tract Diseases; Chemical and Drug In | 2018 |
Directly injected native bone-marrow stem cells cannot incorporate into acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Bone Marrow Cells; Chemical and Drug Induced Liver Injury; Female; Graft Sur | 2018 |
Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.
Topics: Acetaminophen; Acetylglucosamine; Acylation; Animals; Chemical and Drug Induced Liver Injury; Glutat | 2018 |
Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal | 2018 |
Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Cell Line; Chemical and Drug Induced | 2018 |
Silymarin prevents acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Male; Mice; Mi | 2018 |
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Topics: Acetaminophen; Animals; Cannabinoids; Chemical and Drug Induced Liver Injury; Firearms; Humans; Lead | 2018 |
Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats.
Topics: Acetaminophen; Acyclic Monoterpenes; Animals; Chemical and Drug Induced Liver Injury; Cymbopogon; Di | 2018 |
Knockout of ULK1/2 protects against acetaminophen-induced acute liver injury independent of autophagy?
Topics: Acetaminophen; Autophagy; Autophagy-Related Protein-1 Homolog; Chemical and Drug Induced Liver Injur | 2018 |
Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Drugs, Chinese | 2018 |
Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Drugs, Chinese | 2018 |
Mesenchymal stromal cell-derived exosome-rich fractionated secretome confers a hepatoprotective effect in liver injury.
Topics: Acetaminophen; Animals; Bone Marrow Cells; Cell-Derived Microparticles; Chemical and Drug Induced Li | 2018 |
Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro.
Topics: Acetaminophen; Angelica sinensis; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Glutat | 2018 |
Simvastatin protects against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; | 2018 |
Seabuckthorn berry polysaccharide extracts protect against acetaminophen induced hepatotoxicity in mice via activating the Nrf-2/HO-1-SOD-2 signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fruit; Glutathione; Heme Oxygenase-1 | 2018 |
UPLC/QTOF/MS profiling of two Psidium species and the in-vivo hepatoprotective activity of their nano-formulated liposomes.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chromatography, High P | 2018 |
Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2018 |
Protective effect of an L-type calcium channel blocker, amlodipine, on paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Amlodipine; Animals; Anti-Inflammatory Agents; Antioxidants; Calcium Channel Blockers | 2018 |
SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH
Topics: Acetaminophen; Acetylation; Adenosine Triphosphate; Animals; Apoptosis; Chemical and Drug Induced Li | 2018 |
Modified release paracetamol overdose: a prospective observational study (ATOM-3).
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Australia; Charcoal; Chemical and Drug Induced Liver | 2018 |
The beneficial effects of ozone therapy in acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2018 |
Intravenous Paracetamol Overdose: A Pediatric Case Report.
Topics: Acetaminophen; Administration, Intravenous; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartat | 2019 |
Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tum | 2018 |
Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytoprotect | 2018 |
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF MELILOTUS OFFICINALIS L. AGAINST PARACETAMOL AND CARBON TETRACHLORIDE INDUCED HEPATIC INJURY IN MICE.
Topics: Acetaminophen; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cy | 2017 |
Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Circadian | 2018 |
Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Animals; Chemical and Drug Induced Liver Injury; Drug | 2018 |
Letter in reply to Levine et al. Re: hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; H | 2018 |
DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; DNA Damage | 2018 |
Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in Hepatocyte-Driven Liver Regeneration.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Azepines; Cell Proliferation; Chemical and Drug In | 2018 |
Treatment of acetaminophen-induced liver injury with exogenous mitochondria in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2018 |
Protective effects of α-mangostin against acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2018 |
Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; | 2018 |
Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fungal Polysaccharides; Male; Mice; | 2018 |
Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2018 |
New dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus.
Topics: Acetaminophen; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemical an | 2018 |
Pinelliae Rhizoma Praeparatum Involved in the Regulation of Bile Acids Metabolism in Hepatic Injury.
Topics: Acetaminophen; Angiogenic Proteins; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 2018 |
20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotr | 2018 |
Multiple admissions for acetaminophen overdose: Acetaminophen frequent fliers, a new entity?
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Male; Recurrence | 2018 |
Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Hepatocyte | 2018 |
Hepatoprotective effect of chiisanoside against acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Ami | 2019 |
Utilizing Mechanistic Biomarkers in Treating Paracetamol Hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; | 2018 |
Systems Toxicology Approach to Identifying Paracetamol Overdose.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2018 |
Acetaminophen-induced liver injury is attenuated in transgenic fat-1 mice endogenously synthesizing long-chain n-3 fatty acids.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Caenorhabditis elegans Proteins; Chemical and Drug | 2018 |
Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines; | 2018 |
IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; C | 2018 |
In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication.
Topics: Acetaminophen; Allyl Compounds; Anti-HIV Agents; Cell Survival; Chemical and Drug Induced Liver Inju | 2018 |
High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Biomarkers; Cell Line; Chemical and Drug Induced L | 2018 |
Lophirones B and C halt acetaminophen hepatotoxicity by upregulating redox transcription factor Nrf-2 through Akt, PI3K, and PKC pathways.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Biomarkers; Chalcones; Chemical and | 2018 |
Improving Interpretation of New and Old Serum Biomarkers of Drug-Induced Liver Injury Through Mechanistic Modeling.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Mice | 2018 |
Hepatoprotective Effect of Auricularia delicata (Agaricomycetes) from India in Rats: Biochemical and Histopathological Studies and Antimicrobial Activity.
Topics: Acetaminophen; Animals; Anti-Infective Agents; Antioxidants; Basidiomycota; Blood Chemical Analysis; | 2018 |
Cuscuta arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; | 2018 |
Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Autophagy; Chemical and Drug Induced Liver Injury; Drugs, Chinese | 2018 |
Excessive Plasmin Compromises Hepatic Sinusoidal Vascular Integrity After Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2018 |
FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; | 2018 |
Effects of the Kunlun snow chrysanthemum polysaccharides on acetaminophen-induced oxidative stress, inflammation and apoptosis using animal model.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chrysanthemum; Dose-Respo | 2018 |
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochro | 2019 |
4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fomepizole; Glutath | 2018 |
p53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression.
Topics: Acetaminophen; Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Doxorubicin; Male; | 2018 |
High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells.
Topics: Acetaminophen; Adult; Aged; Animals; Apoptosis; Caprylates; Cell Culture Techniques; Cell Survival; | 2018 |
Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Liver Function | 2018 |
[CIRCADIAN DEPENDENCE OF PARACETAMOL HEPATOTOXICITY IN RATS.]
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Female | 2016 |
Protective activity of tovophyllin A, a xanthone isolated from Garcinia mangostana pericarps, against acetaminophen-induced liver damage: role of Nrf2 activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fruit; Garcinia mangostana; Humans; | 2018 |
Inhibition of acetaminophen-induced hepatotoxicity in mice by exogenous thymosinβ4 treatment.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Autophagy; | 2018 |
Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Berberine; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Inflam | 2018 |
Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability.
Topics: Acetaminophen; Animals; Betaine; Catalase; Chemical and Drug Induced Liver Injury; Electron Transpor | 2018 |
Delayed increase in serum acetaminophen concentration after ingestion of a combination medications: a case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Combinations; | 2018 |
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; B | 2018 |
Inter-Individual Variability in Acute Toxicity of R-Pulegone and R-Menthofuran in Human Liver Slices and Their Influence on miRNA Expression Changes in Comparison to Acetaminophen.
Topics: Acetaminophen; Aged; Biological Variation, Individual; Biomarkers; Chemical and Drug Induced Liver I | 2018 |
The Effects of Chronic Iron Overload in Rats with Acute Acetaminophen Overdose.
Topics: Acetaminophen; Acute Disease; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Ov | 2018 |
Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.
Topics: Acetaminophen; Acetic Acid; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cocos; In | 2018 |
Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner.
Topics: Acetaminophen; Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; Hepatocyt | 2018 |
Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Chemical and Drug Induced Liv | 2018 |
Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chamomile; Chemical and Drug Induced Liver Injury; | 2018 |
[Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats].
Topics: Acetaminophen; Acute Disease; Animals; Caragana; Chemical and Drug Induced Liver Injury; Disease Mod | 2018 |
Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetaminophen; Animals; Carnitine O-Palmitoyltransfera | 2018 |
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Hepato | 2019 |
Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Coumarins; Dose-Response | 2018 |
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 2018 |
NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice.
Topics: Acetaminophen; Aldehydes; AMP-Activated Protein Kinases; Animals; Aspartate Aminotransferases; Chemi | 2018 |
Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antihypertensive Agents; Calcium Channel Blockers; | 2018 |
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Membrane Pro | 2018 |
Activated charcoal significantly improved the reliability of methods for quantitative analysis of endogenous substances in biological specimens: Glutathione and cysteine as cases.
Topics: Acetaminophen; Animals; Charcoal; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cy | 2018 |
A Multicenter Study Into Causes of Severe Acute Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Biomarke | 2019 |
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
Topics: Acetaminophen; Animals; Antioxidants; Biopsy; Chemical and Drug Induced Liver Injury; Cytokines; Dis | 2018 |
Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 2018 |
Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animal | 2018 |
Augmenter of Liver Regeneration Protects Against Acetaminophen-Induced Acute Liver Injury in Mice by Promoting Autophagy.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Autophagy; | 2019 |
Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; | 2018 |
GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animals; Antipyretics; Cell | 2019 |
Structure-activity and structure-property relationships of novel Nrf2 activators with a 1,2,4-oxadiazole core and their therapeutic effects on acetaminophen (APAP)-induced acute liver injury.
Topics: Acetaminophen; Cell Line; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; | 2018 |
Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β.
Topics: Acetaminophen; Acute Lung Injury; Animals; Antibodies, Monoclonal; Benzamides; Biomarkers; Chemical | 2018 |
Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3β Pathway.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Antioxidants; Chemical and Drug Induced Liver | 2018 |
Targeted cellular delivery of robust enzyme nanoparticles for the treatment of drug-induced hepatotoxicity and liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Delivery Systems; Enzymes, Immo | 2018 |
Bio and phyto-chemical effect of Amphora coffeaeformis extract against hepatic injury induced by paracetamol in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diatoms; Free Radical | 2018 |
Pharmacokinetic changes of tramadol in rats with hepatotoxicity induced by ethanol and acetaminophen in perfused rat liver model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Chemical and Drug Induced Live | 2019 |
Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2018 |
Protective effects of extracts of Schisandra chinensis stems against acetaminophen-induced hepatotoxicity via regulation of MAPK and caspase-3 signaling pathways.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Caspase 3; Che | 2018 |
Carbon monoxide releasing molecule A-1 attenuates acetaminophen-mediated hepatotoxicity and improves survival of mice by induction of Nrf2 and related genes.
Topics: Acetaminophen; Animals; Antioxidant Response Elements; Antioxidants; Carbon Monoxide; Cell Line, Tum | 2018 |
Paracetamol-induced liver injury modelled in Xenopus laevis embryos.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Biomarkers; Chemical and Drug Induce | 2019 |
The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatin; Chromati | 2018 |
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Topics: Acetaminophen; Cell Culture Techniques; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cry | 2018 |
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induce | 2019 |
Seed and bark extracts of Acacia catechu protects liver from acetaminophen induced hepatotoxicity by modulating oxidative stress, antioxidant enzymes and liver function enzymes in Wistar rat model.
Topics: Acacia; Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Che | 2018 |
Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice.
Topics: Acetaminophen; Animals; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver In | 2018 |
Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Apoptotic Protease-Activating | 2018 |
A spatial-temporal model for zonal hepatotoxicity of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Hepatocyte | 2019 |
Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antimetabolites, Antineoplas | 2018 |
Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Apoptosis; Autophagy; Be | 2018 |
Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and D | 2019 |
Hepatoprotective and hepatocurative effects of Spilanthes acmella Murr against paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Asteraceae; Chemical and Drug Induced Liver Injury | 2018 |
Protective effect of
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Catechin; Chemical and Drug Induced Liver Injury; I | 2020 |
Protective effects and possible molecular mechanism of
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Bile Acids and Salts; Chemical and Drug Induced Li | 2018 |
Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2019 |
Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Immunochemistry; Liver; | 2019 |
Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Curcumin; Cytochrome P-450 CYP2E1; H | 2019 |
Antioxidative stress effects of vitamins C, E, and B
Topics: Acetaminophen; Animals; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Liver; | 2018 |
Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans.
Topics: Acetaminophen; Animals; Biomarkers; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury | 2019 |
Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Hep G2 Cells; Huma | 2018 |
Chemical profile, liver protective effects and analgesic properties of a Solanum paniculatum leaf extract.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury | 2019 |
Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Caspases; Chem | 2018 |
CD31 induces inflammatory response by promoting hepatic inflammatory response and cell apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Inflammation; | 2018 |
Prevention of acetaminophen-induced liver injury by alginate.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alginates; Analgesics, Non-Narcotic; Anim | 2019 |
A simple automated method for continuous fieldwise measurement of microvascular hemodynamics.
Topics: Acetaminophen; Animals; Automation; Blood Flow Velocity; Chemical and Drug Induced Liver Injury; Dis | 2019 |
Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; | 2019 |
Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2019 |
Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Dr | 2019 |
p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis Regulatory Proteins; Chemical and Drug I | 2019 |
Hepatoprotective and antioxidant potential of Pycnogenol® in acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Female; Flavonoids; Ma | 2019 |
Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Cell Line; Chemical and Drug Induced Liver Injury; Disea | 2018 |
The Hippo Signaling Pathway in Regenerative Medicine.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatectomy; Hippo Signaling Pathway | 2019 |
Low Serum Hepcidin Is Associated With Reduced Short-Term Survival in Adults With Acute Liver Failure.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Femal | 2019 |
Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Biopsy; Cell Line; Chem | 2018 |
Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Autophagy; Chemical and Drug Induced Liver Injury; | 2018 |
The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.
Topics: Acetaminophen; Animals; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury; En | 2019 |
Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Canada; Chemi | 2019 |
Bioactive phenolic acid-substituted glycoses and glycosides from rhizomes of
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Ferns; Glucos | 2019 |
Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.
Topics: Acetaminophen; Activation, Metabolic; Analgesics, Non-Narcotic; Animals; Cell Communication; Chemica | 2019 |
Can acetaminophen/dimethyl sulfoxide formulation prevent accidental and intentional acetaminophen hepatotoxicity?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Dose-Response Re | 2019 |
Mannan-binding lectin attenuates acetaminophen-induced hepatotoxicity by regulating CYP2E1 expression via ROS-dependent JNK/SP1 pathway.
Topics: Acetaminophen; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; | 2019 |
[Effects of Schisandrae Chinensis Fructus induced CYPs and Nrf2 activation on acute liver injury induced by acetaminophen].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 2018 |
[Protective effect of Fuzheng Yanggan Mixture on drug-induced liver injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2018 |
Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2019 |
Noninvasive Tracking and Regenerative Capabilities of Transplanted Human Umbilical Cord-Derived Mesenchymal Stem Cells Labeled with I-III-IV Semiconducting Nanocrystals in Liver-Injured Living Mice.
Topics: Acetaminophen; Adipogenesis; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Chemical | 2019 |
Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment to rabbits.
Topics: Acetaminophen; Adult; Aged; Animals; Antioxidants; Biomarkers; Case-Control Studies; Chemical and Dr | 2019 |
Simultaneous voltammetric determination of acetaminophen and isoniazid using MXene modified screen-printed electrode.
Topics: Acetaminophen; Biosensing Techniques; Catalysis; Chemical and Drug Induced Liver Injury; Electrodes; | 2019 |
[Protective effect of Ginkgo biloba extract on paracetamol-induced acute hepatic injury in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2018 |
Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring.
Topics: Acetaminophen; Animals; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Chemical and Drug In | 2019 |
The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8
Topics: Acetaminophen; Animals; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; DNA-Bind | 2019 |
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferas | 2021 |
Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical | 2019 |
Topics: Acetaminophen; Animals; Antioxidant Response Elements; Antioxidants; Apoptosis; Chemical and Drug In | 2019 |
Protective effect of 7,3',4'-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Cell Survival; Chemical and Drug Induced Liver Inju | 2019 |
Identification of serum microRNAs as potential toxicological biomarkers for toosendanin-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Chemical and | 2019 |
Acetaminophen Hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2019 |
Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; JNK Mitogen-Activated Pr | 2019 |
Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy.
Topics: Acetaminophen; Animals; Autophagy; Cell Survival; Chemical and Drug Induced Liver Injury; Chromones; | 2019 |
Chronic copper treatment prevents the liver critical balance transcription response induced by acetaminophen.
Topics: Acetaminophen; Animals; Cebus; Chemical and Drug Induced Liver Injury; Copper; Disease Models, Anima | 2019 |
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Topics: Acetaminophen; Arabinofuranosyluracil; Biomarkers; Cell Culture Techniques; Cell Survival; Chemical | 2019 |
Serum miR-122 and miR-192 as biomarkers of intrinsic and idiosyncratic acute hepatotoxicity: A quantitative real-time polymerase chain reaction study in adult albino rats.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Male; MicroRNAs; Rats; R | 2019 |
Allyl methyl trisulfide protected against acetaminophen (paracetamol)-induced hepatotoxicity by suppressing CYP2E1 and activating Nrf2 in mouse liver.
Topics: Acetaminophen; Alanine Transaminase; Allyl Compounds; Animals; Chemical and Drug Induced Liver Injur | 2019 |
Hepatotoxicity risk factors and acetaminophen dose adjustment, do prescribers give this issue adequate consideration? A French university hospital study.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Chemical and Drug Induced Li | 2019 |
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
Topics: Acetaminophen; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; F | 2019 |
Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2019 |
HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced | 2019 |
Lipopolysaccharide protects against acetaminophen-induced hepatotoxicity by reducing oxidative stress via the TNF-α/TNFR1 pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Chemical and Drug Induced Liver Inju | 2019 |
[Investigation on protective effect and efficacy difference of extract of Schisandrae Sphenantherae Fructus and Schisandrae Chinensis Fructus against acetaminophen-induced liver injury].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Fruit; Liver; | 2019 |
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Epigenesis, Genetic; | 2019 |
Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation.
Topics: Acetaminophen; Adult; Alarmins; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cy | 2019 |
Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Artocarpus; Aspartate Aminotransferases; | 2019 |
Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dexmed | 2019 |
FGF1 protects against APAP-induced hepatotoxicity via suppression of oxidative and endoplasmic reticulum stress.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Fibrob | 2019 |
The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Citrus sine | 2019 |
A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Glycogen Synthase | 2019 |
Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Heterocyclic Compou | 2019 |
Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice.
Topics: Acetaminophen; alpha-2-HS-Glycoprotein; Animals; Cells, Cultured; Chemical and Drug Induced Liver In | 2019 |
Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and | 2019 |
Hepaotoprotective and nephroprotective activities of Pistacia integerrima fruit extract in paracetamol intoxicated male rabbits with effect on blood cells count.
Topics: Acetaminophen; Animals; Blood Cell Count; Chemical and Drug Induced Liver Injury; Fruit; Kidney; Mal | 2019 |
Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2019 |
IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice via mitochondrial dysfunction-induced apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Endoplas | 2019 |
Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Glutathione; Lig | 2019 |
The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Benzamides; Cell Death; Chemical and Drug Induced L | 2019 |
Repression of Acetaminophen-Induced Hepatotoxicity in HepG2 Cells by Polyphenolic Compounds from
Topics: Acetaminophen; Alanine Transaminase; Antioxidants; Aspartate Aminotransferases; Celastraceae; Cell S | 2019 |
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2019 |
Chi3l1 regulates APAP-induced liver injury by promoting macrophage infiltration.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chitinase-3-Like Pr | 2019 |
Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Interleuk | 2019 |
Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
Topics: Acetaminophen; Animals; Biomarkers; Cannabidiol; Cannabis; Chemical and Drug Induced Liver Injury; D | 2019 |
Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling.
Topics: Acetaminophen; Alkenes; Animals; Anti-Inflammatory Agents; Apoptosis; Chemical and Drug Induced Live | 2019 |
A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Biological Transport, Active; Biomed | 2019 |
Marine macro-algae attenuates nephrotoxicity and hepatotoxicity induced by cisplatin and acetaminophen in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Chemical and Drug Induced L | 2019 |
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytoprotec | 2019 |
Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Down-Regula | 2019 |
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Topics: Acetaminophen; Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Kelch-Like | 2019 |
Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity.
Topics: Acetaminophen; Animals; Antidotes; Antipyretics; Chemical and Drug Induced Liver Injury; Drug Overdo | 2019 |
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug | 2019 |
Effects of Photoperiod on Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Cytochrome P-450 C | 2020 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver | 2019 |
Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2019 |
Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study.
Topics: Acetaminophen; Alanine Transaminase; Aminophylline; Animals; Aspartate Aminotransferases; Chemical a | 2013 |
Chronic acetaminophen exposure in pediatric acute liver failure.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; | 2013 |
Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury.
Topics: Acetaminophen; Acetanilides; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver | 2013 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca | 2013 |
Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by buthionine sulfoximine, arsenic, and acetaminophen.
Topics: Acetaminophen; Animals; Antioxidants; Arsenic; Autocrine Communication; Buthionine Sulfoximine; Chem | 2013 |
Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
Topics: Acacia; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Alloxan; Animals; Aspartate Amino | 2013 |
Urgent need for proactive leadership in local suicide prevention plans.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug | 2013 |
Dissemination and uptake of a new treatment pathway for paracetamol poisoning in the UK: a survey of healthcare professionals.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Delivery of Health Care; Gove | 2013 |
Remarks on Sasidharan et al. "Evaluation of the hepatoprotective effects of lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage". Molecules 2012, 17, 13937-13947.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Oleanolic Acid | 2013 |
The role of infliximab on paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antibodies, Monoclonal; Antioxidants; Chemical and Drug Induced Liver Injury | 2013 |
The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Analgesics, Non-Narcotic; Animals; Antioxidants; Apo | 2013 |
Antioxidative burst and hepatoprotective effects of ethanol root extract of Hippocratea africana against paracetamol-induced liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dose-Response Relation | 2013 |
Glycocapture-assisted global quantitative proteomics (gagQP) reveals multiorgan responses in serum toxicoproteome.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blood Proteins; Chemical and | 2013 |
The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Ana | 2013 |
Identification of endogenous reference genes for RT-qPCR analysis of plasma microRNAs levels in rats with acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Data Interpretation, Sta | 2013 |
Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: a case study with acetaminophen.
Topics: Acetaminophen; Analgesics; Animal Testing Alternatives; Animals; Chemical and Drug Induced Liver Inj | 2013 |
Curcumin attenuated paracetamol overdose induced hepatitis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2013 |
Hepatoprotective activity of Hepax-a polyherbal formulation.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Humans | 2011 |
Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Antiox | 2012 |
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2013 |
Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2013 |
Davallialactone protects against acetaminophen overdose-induced liver injuries in mice.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; C | 2013 |
Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats.
Topics: Acetamides; Acetaminophen; Alanine Transaminase; Animals; Antidepressive Agents; Aspartate Aminotran | 2013 |
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin | 2013 |
The regulation of T-cell recruitment to the human liver during acute liver failure.
Topics: Acetaminophen; Biomarkers; Cell Adhesion; Cell Adhesion Molecules; Cell Separation; Cells, Cultured; | 2013 |
Effects of phospholipid hepatoprotectors on apoptosis during experimental liver pathology induced by isoniazid and paracetamol.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Apoptosis; Bilirubin; Carotenoids; Chemical and Drug I | 2013 |
Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Glutathi | 2013 |
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2013 |
Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apigenin; Chemical and Drug Induced Liver Injury; Glut | 2013 |
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Mice; Mice, Inbred C57B | 2013 |
Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism.
Topics: Acetaminophen; Adaptation, Physiological; Animals; Bile Acids and Salts; Chemical and Drug Induced L | 2014 |
Acetaminophen induced gender-dependent liver injury and the involvement of GCL and GPx.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Gl | 2013 |
Hepatoprotective effects of kombucha tea: identification of functional strains and quantification of functional components.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Beverages; Camelli | 2014 |
Chelidonium majus L. does not potentiate the hepatic effect of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chelidonium; Chemical and Drug Induced Liver Injur | 2013 |
A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Gene Expression Regul | 2013 |
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa | 2013 |
Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Biomarkers; Chemical and Drug Induced | 2013 |
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Chemical and Drug Induced Liver Injury; Chemokines | 2013 |
How safe is acetaminophen?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Persistently elevated troponin I in paracetamol hepatotoxicity: association with liver injury, organ failure, and outcome.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and D | 2013 |
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; | 2013 |
Roles of lipoxin A4 in preventing paracetamol-induced acute hepatic injury in a rabbit model.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical | 2013 |
The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induce | 2014 |
Subtotal hepatectomy and whole graft auxiliary transplantation for acetaminophen-associated acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2014 |
Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzothiazoles; Biphenyl Compounds; Catalase; Chem | 2014 |
Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Li | 2014 |
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.
Topics: Acetaminophen; Animals; Cell Movement; Cell Proliferation; Chemical and Drug Induced Liver Injury; E | 2013 |
Hepatoprotective and antioxidant effects of saponarin, isolated from Gypsophila trichotoma Wend. on paracetamol-induced liver damage in rats.
Topics: Acetaminophen; Animals; Antioxidants; Apigenin; Basidiomycota; Caryophyllaceae; Chemical and Drug In | 2013 |
Effects of administration of subtoxic doses of acetaminophen on liver and blood levels of insulin-like growth factor-1 in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dose-Response Relation | 2016 |
Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Chemical | 2013 |
Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2013 |
Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Apoptosis; Chemical and Drug Induced L | 2013 |
Efficacy of adipose tissue-mesenchymal stem cell transplantation in rats with acetaminophen liver injury.
Topics: Acetaminophen; Adipose Tissue; Animals; Biomarkers; Cells, Cultured; Chemical and Drug Induced Liver | 2013 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced | 2014 |
Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Agaricus; Alanine; Animals; Antioxidants; Biomarkers; Brain; Br | 2013 |
Predicting risk in patients with acetaminophen overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; HMGB1 Protein; Hospitalization; Human | 2013 |
Role of bile acids in liver injury and regeneration following acetaminophen overdose.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestyramine | 2013 |
Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism.
Topics: Acetaminophen; Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Chlorogenic Ac | 2013 |
Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoni | 2013 |
[Paracetamol overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Che | 2014 |
Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Calmodulin; Carbonic Anhydrase III; Chemical and Drug Induced Li | 2014 |
Codeine and acetaminophen recommendations for children.
Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induce | 2013 |
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
Topics: Acetaminophen; Animals; Boron Compounds; Chemical and Drug Induced Liver Injury; Connexins; Cytochro | 2013 |
Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Camellia sinensis; Chemical and Drug Induced Liver Injury; Dose-Response Rel | 2013 |
Interleukin-4 deficiency protects mice from acetaminophen-induced liver injury and inflammation by prevention of glutathione depletion.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokine CXCL1; Glutathione; Inflam | 2014 |
Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Alleles; Biomarkers; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; | 2014 |
Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Alleles; Biomarkers; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; | 2014 |
Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Alleles; Biomarkers; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; | 2014 |
Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Alleles; Biomarkers; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; | 2014 |
MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromos
Topics: Acetaminophen; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Antioxidants; Cell Line, Tumo | 2014 |
Mitochondrial protective effects of Myrica rubra extract against acetaminophen-induced toxicity.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2013 |
Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12.
Topics: Acetaminophen; Alanine Transaminase; Analysis of Variance; Animals; Blotting, Western; Caspase 12; C | 2014 |
Nilotinib interferes with the signalling pathways implicated in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2014 |
Acute liver injury induces nucleocytoplasmic redistribution of hepatic methionine metabolism enzymes.
Topics: Acetaminophen; Acute Disease; Adenosylhomocysteinase; Animals; Chemical and Drug Induced Liver Injur | 2014 |
Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection).
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Liver; M | 2014 |
Acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2013 |
Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antigens, CD; Antigens, Differentiation, Myelo | 2013 |
Reliability of the reported ingested dose for predicting the requirement of N-acetylcysteine in paracetamol overdose patients.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Beware of paracetamol use in alcohol abusers: a potential cause of acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Aminotransferas | 2013 |
Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Chemical and Drug Induced Liver Injury; Critical | 2013 |
Understanding probability and exposure in paracetamol overdose risk assessment.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats.
Topics: Acetaminophen; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; DN | 2014 |
Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; F | 2016 |
When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Letter in response to Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2013 |
Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; | 2014 |
Curcumin protects against acetaminophen-induced apoptosis in hepatic injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; B | 2013 |
Role of connexin 32 in acetaminophen toxicity in a knockout mice model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connexins; Dose-Response Relationshi | 2014 |
Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Case-Cont | 2014 |
5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Arachidonate 5-Lipoxygenase; | 2013 |
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Chemical and Drug Induced | 2013 |
Hepatoprotective action of Panaxatriol saponins against acetaminophen-induced liver injury: what is the mechanism?
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibi | 2014 |
Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.
Topics: Acetaminophen; Aldehyde Oxidase; Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Cyste | 2014 |
New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfera | 2013 |
S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury.
Topics: Acetaminophen; Aldehyde Oxidoreductases; Animals; Chemical and Drug Induced Liver Injury; Liver; Mic | 2014 |
Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Benzoquinones; Chemical and Drug Induced Liver Injury; Glutath | 2014 |
Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2014 |
Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Animals; Antioxidan | 2014 |
Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.
Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspar | 2016 |
Implementation of computerized cumulative acetaminophen dose tracking.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; Cytochrom | 2014 |
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.
Topics: Acetaminophen; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; | 2014 |
Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bosentan; C | 2014 |
Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Animals; Biomarkers; Blood Chemical Analysis; Chemical and Drug Induced | 2014 |
Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Live | 2014 |
Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2014 |
FDA asks physicians to stop prescribing high-dose acetaminophen products.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Huma | 2014 |
Emerging efforts for discovering new biomarkers of liver disease and hepatotoxicity.
Topics: Acetaminophen; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Metabolom | 2014 |
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Age Factors; Alanine Transaminase; Biomarkers; Carnitine; | 2014 |
Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.
Topics: Acetaminophen; Acetanilides; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Li | 2014 |
Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Drug Resistanc | 2014 |
TRPM2 channels mediate acetaminophen-induced liver damage.
Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Calcium; Chemical and Drug Induced | 2014 |
Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Amin | 2014 |
Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2014 |
Hepatoprotective activity of Oxalis corniculata L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its in vitro antioxidant effects.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Ethanol; Liver; Male; | 2014 |
Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chine | 2014 |
Probiotic-based protection of normal tissues during radiotherapy.
Topics: Acetaminophen; Animals; Biological Products; Chemical and Drug Induced Liver Injury; Enterococcus; L | 2014 |
Concealed paracetamol overdose treated as HELLP syndrome in the presence of postpartum liver dysfunction.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cesarean Section; Chemical and Drug Induced Liver In | 2014 |
Treatment with N-acetylcystein and total plasma exchange for extracorporeal liver support in children with paracetamol intoxication.
Topics: Acetaminophen; Acetylcysteine; Ammonia; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Fluorescence Resonance Energ | 2014 |
Fibroblast growth factor 21: a new liver safeguard.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2014 |
PKCs: pernicious kinase culprits in acetaminophen pathogenesis.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; JNK M | 2014 |
Acetaminophen safety: be cautious but not afraid. Read labels and stick to guidelines to prevent this widely used pain and fever remedy from harming your liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
How useful are clinical liver function tests in in vitro human hepatotoxicity assays?
Topics: Acetaminophen; Alanine Transaminase; Albumins; Alkaline Phosphatase; Amiodarone; Aspartate Aminotran | 2014 |
The biliary epithelium gives rise to liver progenitor cells.
Topics: Acetaminophen; Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cells, | 2014 |
Cytoprotective effects of silafibrate, a newly-synthesised siliconated derivative of clofibrate, against acetaminophen-induced toxicity in isolated rat hepatocytes.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2014 |
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacterial Translocation; Chemical and Drug Induced | 2014 |
[Practical analysis of toxic substances useful for clinical toxicology (5). Introduction of a new simple analysis of acetaminophen; ZAP tox Acetaminophen Test].
Topics: Acetaminophen; Antipyretics; Biomarkers; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
Understanding paracetamol-induced liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induced Liver Injury; Human | 2014 |
Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bone Marrow Cells; Cell Differentiation; Chemic | 2014 |
Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2014 |
Protective effect of pioglitazone, a PPARγ agonist against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipid Peroxidation; Pioglitazone; PP | 2014 |
Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzyl Alcohol; Cells, Cultured; Chemical and Drug | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Patient perception and knowledge of acetaminophen in a large family medicine service.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 2014 |
Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; DNA; Hepat | 2015 |
Protective effect of chitosan treatment against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chitosan; Male; Protective Agents; R | 2014 |
Liver: benzyl alcohol limits acute liver injury.
Topics: Acetaminophen; Animals; Benzyl Alcohol; Chemical and Drug Induced Liver Injury; Mice; Toll-Like Rece | 2014 |
Seeking a role, Psi and APAP×AT as acetaminophen risk assessment tools.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2014 |
Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; | 2014 |
Necrosis factor-alpha (TNF-alpha) response in human hepatoma HepG2 cells treated with hepatotoxic agents.
Topics: Acetaldehyde; Acetaminophen; Cell Line; Cell Survival; Central Nervous System Depressants; Chemical | 2014 |
Using acetaminophen safely.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
Hepatoprotective activity of LC-ESI-MS standardized Iris spuria rhizome extract on its main bioactive constituents.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; | 2014 |
Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice.
Topics: Acetaminophen; Adiponectin; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animals; Autoph | 2014 |
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Autophagy; Chemical and Drug Induced Liver Injury; Fruit; Inflamm | 2014 |
Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2014 |
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
Topics: Acetaminophen; Amino Acid Substitution; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced | 2014 |
Highly expressed protein kinase A inhibitor α and suppression of protein kinase A may potentiate acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver | 2014 |
Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes.
Topics: Acetaminophen; Apoptosis; Cell Differentiation; Cell Line; Cells, Cultured; Chemical and Drug Induce | 2014 |
Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Chemical and Dr | 2014 |
Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chemica | 2014 |
The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice.
Topics: Acetaminophen; Adrenergic beta-Agonists; Analgesics, Non-Narcotic; Animals; Cell Line; Chemical and | 2014 |
Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.
Topics: Acetaminophen; Animals; Arteriovenous Malformations; Chemical and Drug Induced Liver Injury; Cytochr | 2014 |
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Biomarkers; Carbamoyl-Phosphate Synthase (A | 2014 |
Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Ammonia; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Pro | 2014 |
Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 2014 |
Protective effects of Baccharis dracunculifolia leaves extract against carbon tetrachloride- and acetaminophen-induced hepatotoxicity in experimental animals.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Baccharis; Carbon Tetrachloride; Chemical and Drug | 2014 |
Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Carboxylic Ester Hydrolases; Cell Prol | 2014 |
Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis.
Topics: Acetaminophen; Aloe; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Hep | 2014 |
Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ferns; Liver; | 2014 |
Liver transplantation in case of acetaminophen poisoning: importance of assessment of the colon if arterial lactate increases despite appropriate care.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; C | 2014 |
Targeted metabolomic study indicating glycyrrhizin’s protection against acetaminophen-induced liver damage through reversing fatty acid metabolism.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnitine; Chemical and D | 2014 |
Early predictors of severe acetaminophen-induced hepatotoxicity in a paediatric population referred to a tertiary paediatric department.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dose-Respo | 2014 |
An elevated neutrophil-lymphocyte ratio is associated with adverse outcomes following single time-point paracetamol (acetaminophen) overdose: a time-course analysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2014 |
Evaluation of hepatic damage by reactive metabolites--with consideration of circadian variation of murine hepatic glutathione levels.
Topics: Acetaminophen; Administration, Oral; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Live | 2014 |
Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2014 |
Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carotenoids | 2014 |
FDA: dentists should discontinue prescribing high doses of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dentists; Drug Pres | 2014 |
Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fasting; Femal | 2014 |
Hepatoprotective effects of Met-enkephalin on acetaminophen-induced liver lesions in male CBA mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enkephalin, Methionine; Humans; Live | 2014 |
Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Cell Death; Cells, Cultured; Chemical and Drug Induc | 2014 |
Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and | 2014 |
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemic | 2015 |
Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells.
Topics: Acetaminophen; Administration, Oral; Animals; Biological Availability; Cell Line; Chemical and Drug | 2014 |
Paracetamol-induced Stevens Johnson syndrome and cholestatic hepatitis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Eruptio | 2015 |
Acetaminophen-induced liver injury in a woman with febrile flare of systemic lupus erythematosus.
Topics: Acetaminophen; Acetylcysteine; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Fever; | 2014 |
Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model.
Topics: Acetaminophen; Animals; Cell Cycle; Chemical and Drug Induced Liver Injury; Liver; Liver Regeneratio | 2014 |
Concerns on the precision of the estimation and the quality management of the data.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Humans; Male | 2014 |
Response to Bae et al.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Humans; Male | 2014 |
Protective effects of pterostilbene against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Biomarkers; Chemical and Drug Induce | 2015 |
Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.
Topics: Acetaminophen; Animals; Antioxidants; Carboxylic Ester Hydrolases; Cell Proliferation; Chemical and | 2014 |
Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Chemical and Drug Induced Liver Injur | 2014 |
Modulation of γ2-MSH hepatoprotection by antisense peptides and melanocortin subtype 3 and 4 receptor antagonists.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Ma | 2015 |
The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Dose-Respons | 2015 |
Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.
Topics: Acetaminophen; Adult; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; Chol | 2014 |
Protective effects of Iranian Achillea wilhelmsii essential oil on acetaminophen-induced oxidative stress in rat liver.
Topics: Acetaminophen; Achillea; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Function Test | 2015 |
Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; | 2015 |
The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 2015 |
S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.
Topics: Acetaminophen; Aldehydes; Animals; Antioxidants; Carbamoyl-Phosphate Synthase (Ammonia); Chemical an | 2014 |
Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of Lophira lanceolata and intoxicated with paracetamol (acetaminophen).
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2014 |
Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Antioxidants; Biphenyl Compounds; Boswellia; Chemical | 2014 |
A new isoflavonoid from seeds of Lepidium sativum L. and its protective effect on hepatotoxicity induced by paracetamol in male rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal | 2014 |
Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Bupleurum; Chemical and Drug Induced | 2014 |
Label-free visualization of acetaminophen-induced liver injury by high-speed stimulated Raman scattering spectral microscopy and multivariate image analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2014 |
Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2015 |
Therapeutic hypothermia in acute liver failure: a multicenter retrospective cohort analysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Chemical and Drug Induced Liver Injury; | 2015 |
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis Regulatory Proteins; Benzoquinones; Binding | 2015 |
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2015 |
Evaluation of hepatoprotective activity of aqueous extracts of leaves of Basella alba in albino rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Function Tests; Magnoli | 2015 |
Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Adult; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; Drug | 2015 |
Hepatoprotective and anti-oxidant activities of Glossogyne tenuifolia against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Antipyretics; | 2014 |
Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.
Topics: Acetaminophen; Acute Disease; Albumins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonoc | 2015 |
Glucosamine enhances paracetamol bioavailability by reducing its metabolism.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Biological Availability; Biotransfor | 2015 |
Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats.
Topics: Acetaminophen; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and D | 2014 |
Protective effect of Baccharis trimera extract on acute hepatic injury in a model of inflammation induced by acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Antipyretics; | 2014 |
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.
Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and D | 2015 |
M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Blotting, Western; Cell Proliferation; | 2015 |
Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.
Topics: Acetaminophen; Biomarkers; Cell Differentiation; Chemical and Drug Induced Liver Injury; Child; Chil | 2015 |
Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Bilirubin; Che | 2014 |
Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bee Venoms; Chemical and | 2014 |
Phytoextract of Indian mustard seeds acts by suppressing the generation of ROS against acetaminophen-induced hepatotoxicity in HepG2 cells.
Topics: Acetaminophen; Antioxidants; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Mustard P | 2015 |
Hepatoprotective effect of fermented ginseng and its major constituent compound K in a rat model of paracetamol (acetaminophen)-induced liver injury.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Disease Mo | 2015 |
Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cystathion | 2015 |
Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biological | 2014 |
Attenuation of copaiba oil in hepatic damage in rats.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminot | 2014 |
MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.
Topics: Acetaminophen; Adenosine Triphosphate; Aged; Cell Differentiation; Cell Survival; Chemical and Drug | 2015 |
Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring.
Topics: Acetaminophen; Adult; Adult Children; Analgesics, Non-Narcotic; Animals; Asthma; Chemical and Drug I | 2015 |
Stimuli-responsive electrodes detect oxidative stress and liver injury.
Topics: Acetaminophen; Animals; Biosensing Techniques; Chemical and Drug Induced Liver Injury; Electrodes; H | 2015 |
Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herba | 2015 |
Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bariatric Surgery; Chemical and Drug Induced Liver I | 2015 |
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.
Topics: Acetaminophen; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cells, Cultured; Chemical an | 2015 |
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; fas Recept | 2015 |
Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2015 |
Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Prolifera | 2015 |
Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bip | 2015 |
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2015 |
ABCD: a simple mnemonic for the King's College Hospital criteria in paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Decision Support Te | 2014 |
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclod | 2015 |
Chemical composition and hepatoprotective activity of ethanolic root extract of Taraxacum Syriacum Boiss against acetaminophen intoxication in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Chemical and Drug | 2015 |
Paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2015 |
Patients with acute liver failure listed for superurgent liver transplantation in France: reevaluation of the Clichy-Villejuif criteria.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chi-Square Distribution; Decision Support Tec | 2015 |
Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: risk of liver toxicity.
Topics: Acetaminophen; Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Su | 2015 |
Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice.
Topics: Acetaminophen; Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 2015 |
Regulatory T cells ameliorate acetaminophen-induced immune-mediated liver injury.
Topics: Acetaminophen; Animals; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Cytokine | 2015 |
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokine CCL20; Disease Models, Ani | 2015 |
Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.
Topics: Acetaminophen; Adenosine Triphosphate; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Resp | 2015 |
Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.
Topics: Acetaminophen; Adolescent; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Prescho | 2015 |
Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Benzofurans; Cell Death; Chemical an | 2015 |
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemic | 2014 |
Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Hepatitis C; Mice; Mice, | 2015 |
Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Proliferation; Chemical and Drug Induced Live | 2015 |
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctan | 2015 |
PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats.
Topics: Acetaminophen; Animals; Benzamides; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Kidne | 2015 |
Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzofurans | 2015 |
Limitations of AST/ALT ratio in paracetamol poisoning.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2015 |
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? The authors reply.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2015 |
Sulforaphane protects against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticarcinogenic Agents; Cells, Cultured; Chemical | 2015 |
Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Disulfide; | 2015 |
Acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2015 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; A | 2015 |
Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Electron Transport Chain Complex Proteins; He | 2015 |
Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Benzoquinones; Chemica | 2015 |
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragm | 2015 |
Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Adult; Area Under Curve; Biomarkers; Chemical and Drug Induced Liver Injury; Cohort S | 2015 |
Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cell Shape; Cells, Cultured; Chemical and Drug Ind | 2015 |
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induce | 2015 |
Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Electron Transport Chain Complex Proteins; He | 2015 |
Protective effects of ethanolic extract of Nigella sativa seed in paracetamol induced acute hepatotoxicity in vivo.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Apoptosis; Asparta | 2014 |
IL-6 trans-signaling plays important protective roles in acute liver injury induced by acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2015 |
[Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2015 |
Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Gene | 2015 |
Investigation of acetaminophen toxicity in HepG2/C3a microscale cultures using a system biology model of glutathione depletion.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cell Line, Tumor; Chemical an | 2015 |
Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Animals; Antioxidants; Apocynum; Cells, Cultured; Chemical and Drug Induced Liver Inj | 2015 |
Hepatotoxicants induce cytokine imbalance in response to innate immune system.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemokines; Chroman | 2015 |
Hepatotoxicity induced by acute and chronic paracetamol overdose in adults. Where do we stand?
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2015 |
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Amoxicillin-Potassium Clavulanate Combinatio | 2015 |
Challenges with AST/ALT ratio in acetaminophen poisoning--the authors reply.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2015 |
Protein-Derived Acetaminophen-Cysteine Can Be Detected After Repeated Supratherapeutic Ingestion of Acetaminophen in the Absence of Hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver In | 2015 |
Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; | 2015 |
Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2015 |
Liver transplant associated with paracetamol overdose: results from the seven-country SALT study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2015 |
Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Intracranial | 2015 |
Paracetamol induced liver failure varies widely across Europe, study finds.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fran | 2015 |
Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injur | 2015 |
Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone.
Topics: Acetaminophen; Activation, Metabolic; Amiodarone; Analgesics, Non-Narcotic; Anti-Arrhythmia Agents; | 2016 |
Targeted delivery of AAV-transduced mesenchymal stromal cells to hepatic tissue for ex vivo gene therapy.
Topics: Acetaminophen; Allografts; Animals; Chemical and Drug Induced Liver Injury; Dependovirus; Genetic Th | 2017 |
The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Che | 2015 |
Antioxidant and hepatoprotective activity of vitex honey against paracetamol induced liver damage in mice.
Topics: Acetaminophen; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver I | 2015 |
Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.
Topics: Acetaminophen; Adult; Bile; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Fluoroq | 2015 |
Chemoprotective effects of a recombinant protein from Pyropia yezoensis and synthetic peptide against acetaminophen-induced Chang liver cell death.
Topics: Acetaminophen; Amino Acid Sequence; Base Sequence; Cell Death; Cell Line; Chemical and Drug Induced | 2015 |
Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.
Topics: Acetaminophen; Activation, Metabolic; Analgesics, Non-Narcotic; Cells, Cultured; Chemical and Drug I | 2016 |
Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Line; Chemical and Drug Induced Liver In | 2015 |
Where are we now with paracetamol?
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2015 |
Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Databases, Factual | 2016 |
External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Bio | 2015 |
The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2016 |
Alpha-lipoic acid treatment of acetaminophen-induced rat liver damage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2015 |
Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antithrombin III; Blood Coagulation; Blood Platele | 2015 |
Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regeneration in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bio | 2015 |
Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Bile Acids and Salts; Biomarkers; Chemical and Drug | 2015 |
Visualization of acetaminophen-induced liver injury by time-of-flight secondary ion mass spectrometry.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Nucleus; Chemical and Drug Induced Liver Inju | 2015 |
A cross-omics analysis of acetaminophen-induced hepatotoxicity in rat liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Profiling; Genomics; | 2015 |
Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Cell Line; Cell Survival; Chemical a | 2015 |
Challenges with AST/ALT ratio in acetaminophen poisoning.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2015 |
Changing the Management of Paracetamol Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Antiemetics; Biomar | 2015 |
Thearubigins protect against acetaminophen-induced hepatic and renal injury in mice: biochemical, histopathological, immunohistochemical, and flow cytometry study.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Apoptosis; Camellia sinensis; Catechin; Chemical and Dr | 2016 |
Paracetamol overdose in Hong Kong: is the 150-treatment line good enough to cover patients with paracetamol-induced liver injury?
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2015 |
High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity.
Topics: Acetaminophen; Amodiaquine; Animals; Carbamazepine; Cell Line, Tumor; Cell Survival; Cells, Cultured | 2015 |
Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury | 2015 |
Prenatal acetaminophen affects maternal immune and endocrine adaptation to pregnancy, induces placental damage, and impairs fetal development in mice.
Topics: Acetaminophen; Adaptation, Physiological; Animals; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Prophylactic and Therapeutic Potential of Acetyl-L-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Acetylcarnitine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver | 2016 |
The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats.
Topics: Acetaminophen; Alanine Transaminase; Amides; Angiotensin II; Animals; Antioxidants; Aspartate Aminot | 2016 |
Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3β axis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2015 |
A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidote | 2015 |
Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics; Animals; Antipyretics; Apoptosis; Chemical and Drug Induced Liver Injury; | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Asparta | 2016 |
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Ov | 2015 |
Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Ap | 2016 |
Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; In | 2015 |
Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity.
Topics: Acetaminophen; Alanine Transaminase; Angiogenic Proteins; Animals; Aspartate Aminotransferases; Chem | 2016 |
Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Brassica; Chemical and Drug Induced Liver Injury; Cytoprotection | 2015 |
Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.
Topics: Acetaminophen; Acute Lung Injury; Animals; B-Lymphocytes; Chemical and Drug Induced Liver Injury; Di | 2015 |
The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity?
Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Necrosis; Receptor-Interac | 2016 |
Determinants of outcome among patients with acute liver failure listed for liver transplantation in the United States.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Foll | 2016 |
Biochemical and Histological Effects of Thiamine Pyrophosphate against Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Inju | 2016 |
Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; | 2015 |
Platelets mediate acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Antithrombin III; Blood Platelets; Chemical and Drug Induced Liver Injury; H | 2015 |
The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chromatogr | 2015 |
Is montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?
Topics: Acetaminophen; Acetates; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induce | 2016 |
Re: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2015 |
Response to Letter to the Editor: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2015 |
The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Antidotes; Chemical and Drug Induced Liver Injur | 2015 |
Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.
Topics: Acetaminophen; Acute Kidney Injury; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Ind | 2015 |
Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.
Topics: Acetaminophen; Cell Differentiation; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Gene | 2016 |
Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alpinia; Animals; Antioxidants; Chemical and Dr | 2015 |
Letter in reply to Riggan et al. Re: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2015 |
Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2015 |
The Protective Action of the Aqueous Extract of Auricularia polytricha in Paracetamol Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Basidiomycota; Chemical and Drug Induced Liver Inj | 2016 |
Paracetamol overdose: relevance of recent evidence for managing patients in Sri Lanka.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dis | 2015 |
Acetaminophen-induced liver injury: Implications for temporal homeostasis of lipid metabolism and eicosanoid signaling pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Eicosanoids; Fatty Acids, Nonesterif | 2015 |
Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Benzyl Alcohol; Chemical and D | 2015 |
Trends in rates of acetaminophen-related adverse events in the United States.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2016 |
Highlight report: biomarkers of acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Humans | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and D | 2016 |
Nomogram line crossing after acetaminophen combination product overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid | 2016 |
Letter in response to: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injur | 2015 |
In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and D | 2016 |
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; A | 2016 |
Highlight report: acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2015 |
Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver | 2016 |
Transplantation of hESC-derived hepatocytes protects mice from liver injury.
Topics: Acetaminophen; Animals; Biliary Tract; Cell Differentiation; Cell Line; Chemical and Drug Induced Li | 2015 |
Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Drug Resistance; Glutat | 2015 |
Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 CYP3A; | 2016 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2015 |
Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Biopsy, Needle; Cell Death; Cell Proli | 2016 |
Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dise | 2015 |
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Che | 2016 |
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Case-Control Studies; C | 2016 |
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antifungal Agents; Cells, Cultured | 2016 |
Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; | 2016 |
Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Binding Sites; Caffeic Ac | 2016 |
Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR.
Topics: Acetaminophen; Alanine Transaminase; Analgesics; Animals; Antipyretics; Aspartate Aminotransferases; | 2016 |
Connexin32: a mediator of acetaminophen-induced liver injury?
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Connexins; Cyt | 2016 |
A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
Topics: Acetaminophen; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 2016 |
On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay.
Topics: Acetaminophen; Biomimetic Materials; Chemical and Drug Induced Liver Injury; Drug Evaluation, Precli | 2016 |
Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Biomarkers; Biotransformation; Che | 2016 |
The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-HIV Agents; Cell Line; Chemical and Drug Induced Liver | 2016 |
Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen.
Topics: Acetaminophen; Administration, Intravenous; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical an | 2016 |
Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdo | 2016 |
Curcumin prevents paracetamol-induced liver mitochondrial alterations.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Curcumin; Disease Models, Animal; Do | 2016 |
Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; G | 2016 |
A Systematic Strategy for Screening and Application of Specific Biomarkers in Hepatotoxicity Using Metabolomics Combined With ROC Curves and SVMs.
Topics: Acetaminophen; Animals; Atorvastatin; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Li | 2016 |
Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription.
Topics: Acetaminophen; Animals; Blotting, Western; Bortezomib; Chemical and Drug Induced Liver Injury; Cytoc | 2016 |
Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidant Response Elements; Chemical and Drug I | 2016 |
N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice.
Topics: Acetaminophen; Acetylcysteine; Age Factors; Analgesics, Non-Narcotic; Animals; Chemical and Drug Ind | 2016 |
Acetaminophen Induced Hepatotoxicity in Wistar Rats--A Proteomic Approach.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Liver; M | 2016 |
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Adenoviridae; Animals; Chemical and Drug Induce | 2016 |
Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.
Topics: Acetaminophen; Amidohydrolases; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; | 2016 |
How to treat paracetamol overdose and when to do it.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Hum | 2016 |
Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.
Topics: Acetaminophen; Animals; Caspase 3; Caspase 7; Cell Line; Chemical and Drug Induced Liver Injury; Chl | 2016 |
Aconitum carmichaelii protects against acetaminophen-induced hepatotoxicity via B-cell lymphoma-2 protein-mediated inhibition of mitochondrial dysfunction.
Topics: Acetaminophen; Aconitum; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver In | 2016 |
Involvement of connexin43 in acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2016 |
Potential adjunct treatment for high-risk acetaminophen overdose.
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibi | 2016 |
3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Mice | 2016 |
Hepatoprotective Activity.
Topics: Acetaminophen; Animals; Antioxidants; Bioprospecting; Chemical and Drug Induced Liver Injury; Cytopr | 2016 |
The protection of glycyrrhetinic acid (GA) towards acetaminophen (APAP)-induced toxicity partially through fatty acids metabolic pathway.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; As | 2015 |
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Topics: Acetaminophen; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Child, Pres | 2016 |
Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.
Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver | 2016 |
Protective effect of allyl methyl disulfide on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2016 |
Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cochlea; Drug | 2016 |
PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Topics: Acetaminophen; Alarmins; Animals; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Inju | 2016 |
Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Activation, Metabolic; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; | 2017 |
Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; Liver | 2016 |
Effects of Hepatoprotective Compounds from the Leaves of Lumnitzera racemosa on Acetaminophen-Induced Liver Damage in Vitro.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Combretaceae; Hep G2 Cells; Humans; In Vitro | 2016 |
Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Cytochro | 2016 |
Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Chem | 2016 |
Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2016 |
Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Gene Expression Profilin | 2016 |
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; Humans; Liver; Ma | 2016 |
Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily?
Topics: Acetaminophen; Administration, Oral; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Drug | 2016 |
Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antidotes; | 2016 |
Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose.
Topics: Acetaminophen; Animals; beta Catenin; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E | 2016 |
[Clinical pharmacist influence at hospital to prevent overdosed prescription of acetaminophen].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2016 |
Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Acetophenones; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2016 |
Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Mice; | 2016 |
Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway.
Topics: Abietanes; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Liv | 2016 |
Lophirones B and C Attenuate Acetaminophen-Induced Liver Damage in Mice: Studies on Hepatic, Oxidative Stress and Inflammatory Biomarkers.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antiox | 2016 |
The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokines; CX3C Chemokine Receptor | 2016 |
Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2016 |
Beta vulgaris subspecies cicla var. flavescens (Swiss chard): flavonoids, hepatoprotective and hypolipidemic activities.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Beta vulgaris; Carbohydrate Sequence; Chemical and | 2016 |
A Long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies.
Topics: Acetaminophen; Antitubercular Agents; Cell Line; Chemical and Drug Induced Liver Injury; Child, Pres | 2016 |
Antioxidant and Hepatoprotective Efficiency of Selenium Nanoparticles Against Acetaminophen-Induced Hepatic Damage.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Male; Metal Nanopartic | 2017 |
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.
Topics: Acetaminophen; Adult; Alanine Transaminase; Antigens, CD; Biomarkers; Cadherins; Chemical and Drug I | 2017 |
[Good use and knowledge of paracetamol (acetaminophen) among self-medicated patients: Prospective study in community pharmacies].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Weight; Chemical and Drug Induced Liver Injury; | 2016 |
[Paracetamol 665 mg has caused several cases of difficult-to-treat poisoning – New treatment recommendations to prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2016 |
The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Hypoglycem | 2016 |
Preventing inpatient acetaminophen overexposure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Inpatients; | 2016 |
Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms.
Topics: Acetaminophen; Animals; Antioxidants; Bauhinia; Chemical and Drug Induced Liver Injury; Liver; Male; | 2016 |
Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline.
Topics: Acetaminophen; Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Defe | 2016 |
Mechanisms of Acetaminophen Hepatotoxicity: Do We Need JNK for Cell Death?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cell Death; Chemical and Drug Induced Liver Injury; Humans | 2016 |
Identification of microRNA biomarker candidates in urine and plasma from rats with kidney or liver damage.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cisplatin; Disease Model | 2017 |
BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemokines; Li | 2016 |
From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases.
Topics: Acetaminophen; Adult; Aged; Amish; Animals; Bone Density; Calcium; Cation Transport Proteins; Chemic | 2016 |
[The functions of nuclear receptors in acetaminophen induced hepatotoxicity].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Receptors, Cytoplasmic and Nuclear | 2016 |
Amelioration of acetaminophen induced hepatotoxicity by methanolic extract of pomegranate peels in rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2016 |
Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxida | 2016 |
NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling.
Topics: Acetaminophen; Animals; Berberine; Chemical and Drug Induced Liver Injury; Humans; Inflammasomes; In | 2016 |
Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?
Topics: Acetaminophen; Acute Disease; Adolescent; Age Distribution; Analgesics, Non-Narcotic; Chemical and D | 2017 |
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antibodies, Neutralizing; Antipyretics; Chemical a | 2016 |
Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2016 |
The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol.
Topics: Acetaminophen; Animals; Capparis; Chemical and Drug Induced Liver Injury; Liver; Plant Extracts; Rat | 2016 |
Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Nucleus; Central Nervous System Depressants; | 2016 |
Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver.
Topics: 3' Untranslated Regions; Acetaminophen; Analgesics, Non-Narcotic; Basic Helix-Loop-Helix Transcripti | 2016 |
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
Topics: Acetaminophen; Animals; Cell Line; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Li | 2016 |
Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation.
Topics: Acetaminophen; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Chemical and Dru | 2016 |
Human Ex-Vivo Liver Model for Acetaminophen-induced Liver Damage.
Topics: Acetaminophen; Aged; Biomarkers; Chemical and Drug Induced Liver Injury; DNA, Mitochondrial; Female; | 2016 |
The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced | 2016 |
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect | 2016 |
Expression of miRNA-122 Induced by Liver Toxicants in Zebrafish.
Topics: Acetaminophen; Animals; Biological Assay; Biomarkers; Chemical and Drug Induced Liver Injury; Drug E | 2016 |
Effects of luteolin and quercetin 3-β-d-glucoside identified from Passiflora subpeltata leaves against acetaminophen induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Luteolin; Male; Mice; Passiflora; Pl | 2016 |
Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice.
Topics: Acetaminophen; Animals; Antigens, CD; Bone Marrow Cells; Cell Differentiation; Chemical and Drug Ind | 2016 |
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Topics: Acetaminophen; Adult; Aged; Animals; Biomarkers; Blood Chemical Analysis; Carbon Tetrachloride; Chem | 2016 |
Acrolein scavengers, cysteamine and N-benzylhydroxylamine, reduces the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acrolein; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cysteami | 2017 |
Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cholestenes; Enzyme Ac | 2017 |
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injur | 2017 |
Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Chemical and | 2017 |
Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.
Topics: Acetaminophen; Apoptosis; Biological Assay; Biomarkers; Caspase 3; Caspase 7; Cells, Cultured; Chemi | 2016 |
Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Humans; | 2016 |
Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Apoptosis; Chemical and Drug Induced L | 2017 |
Handling missing rows in multi-omics data integration: multiple imputation in multiple factor analysis framework.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Data Inter | 2016 |
Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytotoxins; Fibroblasts; Gene Expres | 2016 |
Leading articles in medical journals in 1966.
Topics: Abortion, Induced; Acetaminophen; Adrenocortical Adenoma; Allopurinol; Analgesics; Antineoplastic Ag | 2016 |
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antiemetics; A | 2017 |
Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2017 |
Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.
Topics: Acetaminophen; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Disease Susceptib | 2016 |
Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2016 |
AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.
Topics: Acetaminophen; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Chemic | 2016 |
The incidence, presentation, outcomes, risk of mortality and economic data of drug-induced liver injury from a national database in Thailand: a population-base study.
Topics: Acetaminophen; Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Antitubercular Agents; Chemical a | 2016 |
Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connexins; Cytokines; Drug Overdose; | 2017 |
Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Humans; L | 2016 |
Serum Acetaminophen Protein Adduct Concentrations in Pediatric Emergency Department Patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Child; | 2017 |
Baicalin Attenuates IL-17-Mediated Acetaminophen-Induced Liver Injury in a Mouse Model.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 2016 |
Early Stage Functions of Mitochondrial Autophagy and Oxidative Stress in Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Humans; Mice; Mice, Knock | 2017 |
Different effects of selective β1-adrenoceptor antagonists, nebivolol or atenolol in acetaminophen-induced hepatotoxicity of rats.
Topics: Acetaminophen; Adrenergic beta-1 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Antioxidan | 2017 |
Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases.
Topics: Acetaminophen; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Down-Regulation; Glutath | 2017 |
l-Methionine and silymarin: A comparison of prophylactic protective capabilities in acetaminophen-induced injuries of the liver, kidney and cerebral cortex.
Topics: Acetaminophen; Animals; Antioxidants; Anxiety; Behavior, Animal; Biomarkers; Brain Diseases; Cerebra | 2017 |
Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Case-Control Studies; Chemical and Drug Induced Live | 2017 |
Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Erythrocyte | 2017 |
GC-MS analysis and hepatoprotective activity of the n-hexane extract of Acrocarpus fraxinifolius leaves against paracetamol-induced hepatotoxicity in male albino rats.
Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; | 2017 |
A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Ea | 2017 |
Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Computational Biology; Computer Simu | 2016 |
Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL/6 mice.
Topics: Acetaminophen; Animals; Antioxidants; Carotenoids; Catalase; Cell Line; Cell Survival; Chemical and | 2017 |
Early activated hepatic stellate cell-derived paracrine molecules modulate acute liver injury and regeneration.
Topics: Acetaminophen; Animals; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; | 2017 |
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Intestines; Kidney; Kup | 2017 |
Outcomes from massive paracetamol overdose: a retrospective observational study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Asp | 2017 |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.
Topics: Acetaminophen; Animals; Antioxidants; Carotenoids; Chemical and Drug Induced Liver Injury; Dose-Resp | 2017 |
Adenosine 5'-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation.
Topics: Acetaminophen; Adenosine Monophosphate; Animals; Chemical and Drug Induced Liver Injury; Cytoprotect | 2017 |
Successful treatment of donor-derived hepatitis C viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens.
Topics: Acetaminophen; Adult; Allografts; Antiviral Agents; Benzimidazoles; Blood-Borne Pathogens; Chemical | 2017 |
Inhibition of Glycogen Synthase Kinase 3 Accelerated Liver Regeneration after Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cy | 2017 |
A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.
Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2017 |
ERK Signaling Pathway Plays a Key Role in Baicalin Protection Against Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2017 |
xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway.
Topics: Acetaminophen; Amino Acid Transport System y+; Animals; Chemical and Drug Induced Liver Injury; Cyst | 2017 |
Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cytochrome P-450 C | 2017 |
Haemodialysis in acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2017 |
Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Gene Deletio | 2017 |
New aspects on the hepatoprotective potential associated with the antioxidant, hypocholesterolemic and anti-inflammatory activities of Vernonia condensata Baker.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Cell Line; | 2017 |
Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Early Diagnosis; Fluorescent Dyes; M | 2017 |
Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity.
Topics: Acetaminophen; Cell Differentiation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2 | 2017 |
Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2017 |
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In | 2017 |
Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.
Topics: Acetaminophen; Actins; Animals; Cell Adhesion; Cell Line; Chemical and Drug Induced Liver Injury; He | 2017 |
Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; | 2017 |
Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2017 |
Hepatoprotective Effect of ψ-Glutathione in a Murine Model of Acetaminophen-Induced Liver Toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; | 2017 |
High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.
Topics: Acetaminophen; Adult; Amines; Amino Acids; Aminoquinolines; Carbamates; Chemical and Drug Induced Li | 2017 |
Protective role of p53 in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Benzothiazoles; Chemical and Drug Induced Liver Injury; Gene Knockdown Techn | 2017 |
Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2017 |
Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Bismuth; Body Fluids; Catalysis; Che | 2017 |
Sestrin2 protects against acetaminophen-induced liver injury.
Topics: Acetaminophen; Adenoviridae; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; | 2017 |
Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; | 2017 |
Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apigenin; Aspartate Aminotransferases; C | 2017 |
Elevated procalcitonin is associated with bacterial infection during acute liver failure only when unrelated to acetaminophen intoxication.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bacterial Infections; Biomarkers; C-Reactive Protein | 2017 |
Blockade of Notch signaling promotes acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2017 |
Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspart | 2008 |
Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Dis | 2008 |
Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Chemical and Dr | 2008 |
Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Benzoquinones; Biotransforma | 2008 |
Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspart | 2009 |
Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Aged; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Rad | 2008 |
[Acute acetaminophen overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2008 |
[Accidental acetaminophen overdose].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2008 |
Protective effects of salidroside against acetaminophen-induced toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2008 |
The effects of royal jelly on liver damage induced by paracetamol in mice.
Topics: Acetaminophen; Amino Acids; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injur | 2009 |
Acute liver failure in Lithuania.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Bilirubin; Chemical and Drug Induced Liver Injury; Co | 2008 |
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2008 |
Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Culture Techniques; Chemical and D | 2008 |
Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferase | 2008 |
Acetaminophen-induced, not desflurane-induced, hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Ulcer Agents; Chemical and Dr | 2008 |
Chemoprotective effects of a protein from the red algae Porphyra yezoensis on acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Animals; Caspase 3; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Electr | 2008 |
Innate immunity and acetaminophen-induced liver injury: why so many controversies?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2008 |
How to protect against acetaminophen: don't ask for JUNK.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Humans; JN | 2008 |
Antioxidant and hepatoprotective activity of aqueous extract of Solanum fastigiatum (false "Jurubeba") against paracetamol-induced liver damage in mice.
Topics: Acetaminophen; Animals; Antioxidants; Brazil; Chemical and Drug Induced Liver Injury; Dose-Response | 2008 |
High dose acetaminophen in narcotic combinations: should there be concern?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2008 |
[Experimental study of transplanting human mesenchymal stem cells via portal vein to treat acute liver injury of mice induced with acetaminophen].
Topics: Acetaminophen; Animals; Bone Marrow Cells; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
Effects of tomato extract on oxidative stress induced toxicity in different organs of rats.
Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and D | 2008 |
Protective effect of a fermented substance from Saccharomyces cerevisiae on liver injury in mice caused by acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2008 |
Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Bayes Theorem; Biomark | 2008 |
Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in paracetamol and CCl4 induced hepatotoxicity in Wistar rats.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 2008 |
Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2009 |
A case of nonoliguric acute kidney injury associated with acetaminophen overdose.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Hu | 2008 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aged; Alanine Transaminase; Analgesics, Non-Nar | 2009 |
Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Animals; Cell Survival; Cells, Cultured; Chemi | 2009 |
Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; As | 2009 |
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk?
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and | 2009 |
Effect of Clausena dentata (Willd.) M. Roem. against paracetamol induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2009 |
Acetaminophen hepatotoxicity: current management.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidi | 2009 |
Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; C | 2009 |
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Am | 2009 |
Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hours.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2009 |
Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; | 2009 |
Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Aspartate Aminotr | 2009 |
Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury.
Topics: Acetaminophen; Adrenergic Agonists; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensi | 2009 |
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; | 2009 |
Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors; | 2009 |
Paracetamol poisoning below toxic level causing liver damage in a fasting adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2009 |
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cohort Studies | 2009 |
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Cell Death; Cell Proliferation; Chemic | 2009 |
Hepatoprotective studies on Sida acuta Burm. f.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cou | 2009 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2009 |
[Paracetamol use in patients with liver disease].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea | 2009 |
Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Aniline Compounds; Animals; Anthocyanins; Aspartate Aminotransf | 2009 |
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aspar | 2009 |
Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Canada; Chemical | 2009 |
[Influence of different type beta-adrenoblockers on functional state of liver at paracetamol induced toxic hepatitis in experiment].
Topics: Acetaminophen; Adrenergic beta-Antagonists; Animals; Chemical and Drug Induced Liver Injury; Liver; | 2009 |
Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Alanine Transaminase; Animals; Catechols; Chemical and D | 2009 |
Acetaminophen safety - deja vu.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Consumer Pro | 2009 |
FDA focuses on drugs and liver damage: labeling and other changes for acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antithyroid Agents; Chemical and Drug Induced Liver Injury; | 2009 |
Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Adenoviridae; Analgesics, Non-Narcotic; Animals; Animals, Genetically Modified; Biotr | 2009 |
Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2009 |
FDA's acetaminophen meeting sparks confusion, uncertainty.
Topics: Acetaminophen; Advisory Committees; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury | 2009 |
Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Animals; Aspartate | 2009 |
Brain creatine kinase activity is inhibited after hepatic failure induced by carbon tetrachloride or acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Brain; Carbon | 2009 |
Is the oral acetylcysteine protocol the best treatment for late-presenting acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Drug Ov | 2009 |
Intestinal glucose uptake protects liver from lipopolysaccharide and D-galactosamine, acetaminophen, and alpha-amanitin in mice.
Topics: Acetaminophen; Administration, Oral; Alpha-Amanitin; Animals; Chemical and Drug Induced Liver Injury | 2009 |
Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical | 2009 |
Farnesyltransferase inhibitors reduce Ras activation and ameliorate acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2009 |
Protective effects from carnosine and histidine on acetaminophen-induced liver injury.
Topics: Acetaminophen; alpha-Tocopherol; Animals; Ascorbic Acid; Carnosine; Catalase; Chemical and Drug Indu | 2009 |
Protective Effects of the Supernatant of Ethanol Eluate from Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice [corrected].
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Artemisia; Aspartate Aminotransferases; Cas | 2009 |
Delayed onset of acute renal failure after significant paracetamol overdose: A case series.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcoti | 2010 |
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energ | 2010 |
Changing winds: practice implications of acetaminophen regulations.
Topics: Acetaminophen; Advisory Committees; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury | 2009 |
The effect of the aqueous extract of Kohautia grandiflora on paracetamol-induced liver damage in albino rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2009 |
Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice.
Topics: Acetaminophen; Animals; Artemisia; Chemical and Drug Induced Liver Injury; Liver Function Tests; Mal | 2010 |
Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice.
Topics: Acetaminophen; Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury; Diterpenes; | 2010 |
A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcot | 2009 |
Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Antido | 2009 |
An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Betaine-Homocysteine S-Methyltransferase; Chemical | 2010 |
BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Endoplasmic Ret | 2010 |
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Line; Chemical and Drug Induced Liver Injury; | 2010 |
Comparative impacts of knockouts of two antioxidant enzymes on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2009 |
IV versus oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Ind | 2009 |
Is acetaminophen safe? Accidental overdoses are common, but avoidable.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug | 2010 |
Acetaminophen toxicity with concomitant use of carbamazepine.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anticonvulsants; Back Pain; Carbamazepine; Chemical | 2009 |
Liver damage from chronic acetaminophen dosing is dangerous, but not the only risk.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Autistic Disorder; Chemical and Drug Induced Liver I | 2009 |
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Buthionine Sulfoximine | 2010 |
Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2010 |
Acetaminophen is safe when used correctly.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2009 |
Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Animals; Apoptosis; Aspartate Aminotransferases; Cas | 2010 |
Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Antidote | 2010 |
Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2010 |
Lactoferrin protects against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endothelial Cells; Lactoferrin; Live | 2010 |
Protection by dietary Spirulina platensis against D-galactosamine--and acetaminophen-induced liver injuries.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2010 |
The role of prostacyclin in modifying acute hepatotoxicity of acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2009 |
Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice.
Topics: Acetaminophen; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Endothelial Cells; Er | 2010 |
Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Bromodeoxyuridine; Bronchoal | 2010 |
Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Biotransformation; | 2010 |
Medicine, poison, and mystic potion: a personal perspective on paracetamol Louis Roche lecture, Stockholm, 2009.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induc | 2010 |
Protective activity of the stem bark aqueous extract of Musanga cecropioides in carbon tetrachloride- and acetaminophen-induced acute hepatotoxicity in rats.
Topics: Acetaminophen; Alkaloids; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 2009 |
FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
Topics: Acetaminophen; Advisory Committees; Alcohol Drinking; Analgesics, Opioid; Anti-Inflammatory Agents, | 2010 |
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals | 2010 |
Acetaminophen dose does not predict outcome in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2010 |
Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug In | 2011 |
Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; C | 2010 |
The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice.
Topics: Acetaminophen; Adrenocorticotropic Hormone; Alanine Transaminase; alpha-MSH; Amino Acid Sequence; An | 2010 |
Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Pois | 2010 |
Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models.
Topics: Acetaminophen; Animals; Antioxidants; Catalase; Cell Death; Chemical and Drug Induced Liver Injury; | 2010 |
Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines; | 2010 |
Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Case-Control Studies; Chemical and Drug Indu | 2010 |
Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2010 |
Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity.
Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Drug Interactions; Intr | 2010 |
Assessing the impact of vomiting episodes on outcome after acetaminophen poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Cohort Studies; D | 2010 |
The effect of acetaminophen nanoparticles on liver toxicity in a rat model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2010 |
Clock gene mPer2 functions in diurnal variation of acetaminophen induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2011 |
Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytoprotect | 2010 |
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; CD18 Antigens; Chemical and Drug Induc | 2010 |
Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Corticosterone; Dexamethasone; Femal | 2010 |
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asian; Black or African American; Chemical and Drug | 2010 |
Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Death; Chemical and Drug Induced Liver Injury | 2010 |
Poloxamer 407 increases the recovery of paracetamol in the isolated perfused rat liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Endotheliu | 2011 |
[Are nomograms available for the treatment of acetaminophen poisoning?].
Topics: Acetaminophen; Acetylcysteine; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver Fun | 2010 |
[Are nomograms available for the treatment of acetaminophen poisoning? Pros: usefullness of nomogram-based decision-making in the treatment of acute acetaminophen overdose in Japan: single center experience with 61 consecutive patients in Niigata City Gen
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Biomarkers; Chemical and Drug Induc | 2010 |
Up-regulation of the lysyl hydroxylase 2 gene by acetaminophen and isoniazid is modulated by transcription factor c-Myb.
Topics: Acetaminophen; Binding Sites; Blotting, Western; Chemical and Drug Induced Liver Injury; Fibrosis; G | 2010 |
Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Gallic Acid; Lipid Per | 2010 |
Histopathological study of the hepatic and renal toxicity associated with the co-administration of imatinib and acetaminophen in a preclinical mouse model.
Topics: Acetaminophen; Analgesics; Animals; Antineoplastic Agents; Benzamides; Chemical and Drug Induced Liv | 2010 |
Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.
Topics: Acetaminophen; Animals; Caspase 1; Caspase 3; Caspase Inhibitors; CD11b Antigen; Chemical and Drug I | 2010 |
In vitro antioxidant activity and hepatoprotective effects of Lentinula edodes against paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; M | 2010 |
Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2010 |
Genomic indicators in the blood predict drug-induced liver injury.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Artificial Intelligence; Biomarkers; Carbon Tet | 2010 |
CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression; Genotype; Mice; Mic | 2010 |
The case for limiting acetaminophen-related deaths: smaller doses and unbundling the opioid-acetaminophen compounds.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2010 |
Protective effect of ghrelin on acetaminophen-induced liver injury in rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical | 2010 |
Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers, Pharmacological; Carcinoma, Hepatocell | 2010 |
Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug In | 2010 |
Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2010 |
For the dental patient ... Acetaminophen overdose and liver damage.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug | 2010 |
Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity.
Topics: Acetaminophen; Analysis of Variance; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2010 |
Overdoing acetaminophen. Many overdoses are accidental, so the FDA may require new warnings on the popular pain reliever and lower the daily limit.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2009 |
[Paracetamol for perioperative analgesia. Old substance - new insights].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver | 2010 |
Novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2010 |
Protective effects of Pergularia daemia roots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemi | 2010 |
Glutathione modulation and oxidative stress in human liver slices.
Topics: Acetaminophen; Adenosine Triphosphate; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injur | 2010 |
Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Amino Acid Sequence; Animals; Antidotes; Cell Line; Chemical and Drug Induced Liver I | 2010 |
PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Animals, Genetically Modified; Che | 2010 |
The clinical management of acetaminophen poisoning in a community hospital system: factors associated with hospital length of stay.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; Cal | 2011 |
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; | 2011 |
Hepatoprotective activity of Glycosmis pentaphylla against paracetamol-induced hepatotoxicity in Swiss albino mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2011 |
Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Antipyretics; Biomarkers; B | 2010 |
Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antidotes; A | 2010 |
Comment: a population study of the frequency of high-dose acetaminophen prescribing and dispensing.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2010 |
Influence of small doses of various drug vehicles on acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2010 |
New marker for paracetamol poisoning-revolution or evolution?
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced | 2010 |
When do the aminotransferases rise after acute acetaminophen overdose?
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransfe | 2010 |
Risk of hepatotoxicity-related hospitalizations among patients treated with opioid/acetaminophen combination prescription pain medications.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Drug Combina | 2010 |
Antioxidant and hepatoprotective activity of Aphanizomenon flos-aquae Linn against paracetamol intoxication in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Antipyretics; Aphanizomenon; Aspartate A | 2010 |
Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2011 |
Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; L | 2011 |
Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced L | 2011 |
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
Topics: Acetaminophen; Amiodarone; Blotting, Western; Cell Survival; Chemical and Drug Induced Liver Injury; | 2011 |
Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
Topics: Acetaminophen; Benzoquinones; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Chro | 2011 |
Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; En | 2011 |
Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants | 2011 |
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2011 |
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced | 2011 |
No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2011 |
Secretory phospholipase A₂-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooxyge | 2011 |
Hepatoprotective activity of methanol extract of Amaranthus caudatus Linn. against paracetamol-induced hepatic injury in rats.
Topics: Acetaminophen; Amaranthus; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2011 |
Protective effects of syringic acid against acetaminophen-induced hepatic damage in albino rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Bilirubin; Chemical and Drug Induced Liv | 2010 |
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; | 2011 |
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cysteine; Female; | 2011 |
Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral counting.
Topics: Acetaminophen; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Chromatography, High Pres | 2011 |
Depletion of activated hepatic stellate cell correlates with severe liver damage and abnormal liver regeneration in acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2011 |
Detection of acetaminophen-cysteine adducts in cases of indeterminate liver failure is not diagnostic of intentional overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteine; Drug Overdose; Humans; Liver Failur | 2011 |
Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Asymptomatic Diseases; Chemical and D | 2011 |
Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver In | 2011 |
Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Liver Failure, Acute; Mic | 2011 |
Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclosporine; Gene Expression Reg | 2011 |
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Carrier Proteins; Caspase 1; Chemical and Drug Induced | 2011 |
Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3.
Topics: Acetaminophen; Animals; Antiviral Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 E | 2011 |
Why has the Food & Drug Administration (FDA) limited acetaminophen prescription products to 325 milligrams per dosage?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Prescription Drugs | 2011 |
Protective effect of Woodfordia fruticosa flowers against acetaminophen-induced hepatic toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2011 |
Rhein protects against acetaminophen-induced hepatic and renal toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthraquinones; Antioxidants; Bilirubin; Chemical and | 2011 |
Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2011 |
FDA limits prescription acetaminophen. But be vigilant about over-the-counter acetaminophen, too.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2011 |
Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Analgesics, | 2011 |
Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Concanaval | 2011 |
Prescribing recommendations for the treatment of acute pain in dentistry.
Topics: Acetaminophen; Acute Disease; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroida | 2011 |
Developing consumer-centered, nonprescription drug labeling a study in acetaminophen.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Commun | 2011 |
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Live | 2011 |
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Hypoxia-Inducible Facto | 2011 |
Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Chemica | 2011 |
[Acetaminophen and the liver].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induced Liver Injury; Human | 2011 |
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophili | 2011 |
Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen.
Topics: Acetaminophen; Animals; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Cholesterol; | 2012 |
Acute kidney injury in patients admitted to a liver intensive therapy unit with paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2011 |
Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Death; Chemical a | 2011 |
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Inj | 2011 |
Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzophenones; Chemical and Drug Induced Liver Inj | 2011 |
Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity.
Topics: Acetaminophen; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Cells, Cu | 2011 |
[Q & A. A patient brought in a comatose state, displaying acute hepatic disorder and an area of high absorption in the stomach in CT images].
Topics: Acetaminophen; Adult; Bromisovalum; Chemical and Drug Induced Liver Injury; Codeine; Female; Humans; | 2011 |
Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug Induced Liver Inju | 2011 |
Unexpected late rise in plasma acetaminophen concentrations with change in risk stratification in acute acetaminophen overdoses.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Che | 2012 |
SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylation; Alanine Transaminase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mi | 2011 |
Misuse of acetaminophen in the management of dental pain.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum | 2011 |
SIRT3 deacetylase: the Jekyll and Hyde sirtuin.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Sirtuin 3 | 2011 |
Circulating apoptotic and necrotic cell death markers in patients with acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Apoptosis; Biomarkers; C | 2011 |
Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Drug Delivery | 2011 |
An atypical presentation of neuroleptic malignant syndrome: diagnostic dilemma in a critical care setting.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Creatine Kinase; Diagnosis, Differenti | 2012 |
The outcomes of critically ill patients with combined severe acute liver and kidney injury secondary to paracetamol toxicity requiring renal replacement therapy.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Critical Illness; | 2011 |
Probiotic Enterococcus lactis IITRHR1 protects against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Biological Products; Biom | 2012 |
Elevated serum neopterin levels in acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2011 |
[Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults].
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Aspartate Aminotransferases; C | 2011 |
Acetaminophen psi parameter: a useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and | 2011 |
Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophili | 2011 |
Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Cell Culture Techniques; Cell Cycle; Cell Prolif | 2011 |
Interaction of α-melanocortin and its pentapeptide antisense LVKAT: effects on hepatoprotection in male CBA mice.
Topics: Acetaminophen; Alanine Transaminase; alpha-MSH; Amino Acid Sequence; Animals; Antisense Elements (Ge | 2011 |
Pentraxin 3 as a potential biomarker of acetaminophen-induced liver injury.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biomarkers; C-Reactive Prote | 2013 |
3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Chemical and Drug Induced Liver Inj | 2011 |
Immunohistochemical detection of polyunsaturated fatty acid oxidation markers in acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Biomarkers; Ch | 2012 |
[Acute paracetamol overdose during pregnancy: a case report].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cesarean Section; Chemical and Drug Induced Liver In | 2011 |
Care needed with i.v. acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chemistry, Pharmace | 2011 |
Activation of autophagy protects against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adenine; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and D | 2012 |
Opioid-paracetamol prescription patterns and liver dysfunction: a retrospective cohort study in a population served by a US health benefits organization.
Topics: Acetaminophen; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Comb | 2011 |
Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Andrographis; Anima | 2011 |
Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; DNA; Dose-Response Relationship, Dru | 2012 |
Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2012 |
Acetaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network.
Topics: Acetaminophen; Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Endo | 2012 |
Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2011 |
Screening of ethyl acetate extract of Bridelia micrantha for hepatoprotective and anti-oxidant activities on Wistar rats.
Topics: Acetaminophen; Acetates; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Anima | 2011 |
Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.
Topics: Acetaminophen; Animals; Biocatalysis; Chemical and Drug Induced Liver Injury; CpG Islands; Disease M | 2011 |
Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.
Topics: Acetaminophen; Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Endotoxins; Fa | 2011 |
Changes in mouse liver protein glutathionylation after acetaminophen exposure.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2012 |
[Paracetamol poisonings after the lifting of the place of sale restriction].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug and Narcotic C | 2011 |
Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole.
Topics: Acetaminophen; Animals; Anthelmintics; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1 | 2012 |
Paracetamol overdose: the liver unit perspective.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2012 |
Acute brain damage induced by acetaminophen in mice: effect of diphenyl diselenide on oxidative stress and mitochondrial dysfunction.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; | 2012 |
Toxicity monitoring with primary cultured hepatocytes underestimates the acetaminophen-induced inflammatory responses of the mouse liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2011 |
Tournefortia sarmentosa extract attenuates acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Boraginaceae; Cell Line; Cell Surviv | 2012 |
Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2011 |
6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catechols; | 2011 |
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Line; Chemical and Drug Induced Liver Injury; | 2012 |
Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2012 |
Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2012 |
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bio | 2012 |
Intravenous paracetamol toxicity in a malnourished child.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransf | 2012 |
Acetaminophen increases the risk of arsenic-mediated development of hepatic damage in rats by enhancing redox-signaling mechanism.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arsenic; Catalase; Chemical and Dru | 2014 |
Loss of autophagy promotes murine acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Culture Techniques; | 2012 |
Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2012 |
Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.
Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Biomarkers; Biphenyl Compounds; Butylated Hydroxyto | 2011 |
Trends in hepatic injury associated with unintentional overdose of paracetamol (Acetaminophen) in products with and without opioid: an analysis using the National Poison Data System of the American Association of Poison Control Centers, 2000-7.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2012 |
Comment on "Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophili | 2011 |
Gene expression in rat hearts following oral administration of a single hepatotoxic dose of acetaminophen.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2012 |
Identification of endogenous normalizers for serum microRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Diagnostic Techniques, Digestive System; Fema | 2012 |
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and Drug Induced Liver | 2012 |
Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Caspase 3; Ca | 2012 |
Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Benzoquinones; Chemical and Drug Induced Liver Injury; Cyto | 2012 |
Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.
Topics: Acetaminophen; Ammonia; Analgesics, Non-Narcotic; Animals; Bioartificial Organs; Cells, Cultured; Ch | 2012 |
Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver Regeneration; Male; Mice; Mice | 2012 |
Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure.
Topics: Acetaminophen; Animals; Boron Compounds; Chemical and Drug Induced Liver Injury; Connexins; Gap Junc | 2012 |
Predicting death in patients with acetaminophen-induced acute liver failure: the King's College Hospital model is on the SOFA, not the mat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Health Stat | 2012 |
SOFA score and acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Health Stat | 2012 |
[Basic drugs in pain therapy under discussion. How safe is paracetamol? (interview by Dr. Judith Neumaier)].
Topics: Acetaminophen; Analgesics; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Dose-Res | 2011 |
RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Alanine Transaminase; Apoptosis; Biomarkers; Case-Control Studies; Chemical an | 2012 |
Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Blotting, Western; Chemic | 2012 |
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 2012 |
Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dr | 2012 |
Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.
Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Chemical and Drug Induced Liver Inj | 2012 |
Management of acute paracetamol (acetaminophen) toxicity: a standardised proforma improves risk assessment and overall risk stratification by emergency medicine doctors.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Documentatio | 2012 |
Complement activation in acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Complement Act | 2012 |
Mechanistic biomarkers in acute liver injury: are we there yet?
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; HMGB1 Protein; Humans; Keratin-18; Ma | 2012 |
Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2012 |
Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antigens, CD; Antigens, Differentiation, Myelomonocy | 2012 |
Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver Regeneration; Male; Pyruvates | 2012 |
A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug | 2012 |
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Animals; Biomarkers; Caspase 3; Chemical and Drug | 2012 |
P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antigens, CD; Antipyretics; Apyrase; Cells, Cultured; Chemical and Drug Indu | 2012 |
Liver: determining prognosis in acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; | 2012 |
The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arylsulfotransferase; Carbon Tetrachloride Poisoni | 2012 |
Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2012 |
Effect of Asparagus falcatus on acetaminophen toxicity in mice: a comparison of antioxidative effect with N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Asparagus Plant; Chemica | 2008 |
Targeting autophagy for drug-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Humans; Mice; Mice, Knock | 2012 |
The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2012 |
Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 2012 |
Prescription acetaminophen ingestions associated with hepatic injury and death.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; California; Chemical and Drug Induced Liver Injury; D | 2012 |
[HIP/PAP, a new drug for acute liver failure].
Topics: Acetaminophen; Acute Disease; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Chemical and Drug Indu | 2012 |
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Autophagy; Autophagy-Related Protein 5; Caspase 3; Cell Proliferation; Chemi | 2012 |
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antithrombin III; Blood Coagulation; Chemical and Drug | 2012 |
The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Drug | 2012 |
Paracetamol toxicity: What would be the implications of a change in UK treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Coh | 2012 |
Confusion: acetaminophen dosing changes based on NO evidence in adults.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Labelin | 2012 |
Impairment of α(2)-macroglobulin synthesis in experimental hepatopathic rats treated with turpentine oil.
Topics: Acetaminophen; Acute Disease; alpha-Macroglobulins; Analgesics, Non-Narcotic; Animals; Carbon Tetrac | 2012 |
Liver tumours, toxic hepatitis, intestinal failure-associated liver disease in children.
Topics: Acetaminophen; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-Bacteri | 2012 |
Drug-induced cholestatic hepatitis: how late can it occur even after the cessation of the culpable drug?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Chemical and Drug Induce | 2012 |
Biochemical and histologic presentations of female Wistar rats administered with different doses of paracetamol/methionine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Li | 2011 |
What is your diagnosis? Serum biochemical data from genetically modified mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Gene Expre | 2012 |
Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity.
Topics: Acetaminophen; Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galact | 2012 |
Hepatic injury to the newborn liver due to drugs.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agent | 2012 |
Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Liver; Mitochondria | 2012 |
RE: Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2013 |
Authors' response to Dr Reiter.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2013 |
High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antibodies, Anti-Idiotypic; Aspartate Aminotransferase | 2012 |
Inhibition of GHRH aggravated acetaminophen-induced acute mice liver injury through GH/IGF-I axis.
Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Prec | 2012 |
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
Topics: Acetaminophen; Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; Cytokines | 2012 |
Analysis of plasma nucleotides in rat by micellar electrokinetic capillary chromatography/electrospray ionization mass spectrometry.
Topics: Acetaminophen; Acetates; Animals; Calibration; Chemical and Drug Induced Liver Injury; Chromatograph | 2012 |
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Benzoquinones; Chemical a | 2012 |
Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice.
Topics: 5-Methoxypsoralen; Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Antioxidants; | 2012 |
Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug | 2012 |
Risk of unintentional overdose with non-prescription acetaminophen products.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Confid | 2012 |
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
Topics: 3-Hydroxybutyric Acid; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P- | 2012 |
Fully biodegradable and cationic poly(amino oxalate) particles for the treatment of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acute Disease; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytosol; D | 2012 |
Acetaminophen overdose in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Circumcision, Male; | 2012 |
Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2012 |
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cp | 2012 |
Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Benzoquinones; Blotting, Western | 2012 |
Commentary: SOFA scores and staggered paracetamol overdose prognostication.
Topics: Acetaminophen; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Female; Hum | 2012 |
Dietary fish oil aggravates paracetamol-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2013 |
Protective effects of Capparis sepiaria root extracts against acetaminophen-induced hepatotoxicity in Wistar rats.
Topics: Acetaminophen; Animals; Biomarkers; Capparis; Chemical and Drug Induced Liver Injury; Female; Liver; | 2012 |
Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study.
Topics: Acetaminophen; Alanine Transaminase; Animals; Asthma; Chemical and Drug Induced Liver Injury; Diseas | 2012 |
The dual role of osteopontin in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2012 |
A prospective nationwide study of drug-induced liver injury in Korea.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herba | 2012 |
Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Angiotensin-Convertin | 2012 |
Hepatoprotective effects and antioxidant role of Scutia myrtina on paracetamol induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Ethanol; Free Radical | 2011 |
Hepatoprotective activity of Cyperus tegetum rhizome against paracetamol-induced liver damage in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyperus; L | 2011 |
Re: Remien etal.: mathematical modeling of liver injury and dysfunction after acetaminophen overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Models, Biological; Models, Statistic | 2012 |
Re: Remien et al.: mathematical modeling of liver injury and dysfunction after acetaminophen overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Models, Biological; Models, Statistic | 2012 |
Protective effects of a purified saponin mixture from Astragalus corniculatus Bieb., in vivo hepatotoxicity models.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Astragalus | 2013 |
Paracetamol intoxications: a retrospective population-based study in Iceland.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Chemic | 2012 |
Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.
Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Histocytoche | 2012 |
Paracetamol (acetaminophen) overdose and acetylcysteine administration: should the United Kingdom adopt a single '150-line'?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2012 |
Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemical | 2012 |
Protective effect of fucoidan against acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Prot | 2012 |
Effect of S-methylisothiourea in acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; En | 2012 |
Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Animals; Cathepsin B; Chemical and Drug Induced Liver Injury; Cysteine Protein | 2012 |
Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines; | 2012 |
Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Enzyme Activation; | 2012 |
Enhancement of hepatoprotective efficacy of propolis by fabrication of liposomes, as a platform nano-formulation for multi-component natural medicine.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Che | 2012 |
The social and economic influences on medication use and misuse.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug-Related Side E | 2012 |
Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cleft Palate; Humans; Infusio | 2013 |
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; bcl-2 Homologous Antagonist-Killer | 2012 |
Therapeutic role of telmisartan against acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animal | 2012 |
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antipyretics; Chemical and D | 2012 |
Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
Topics: Acetaminophen; Animals; Carrier Proteins; Cell Survival; Cells, Cultured; Chemical and Drug Induced | 2013 |
Deficiency of interleukin-15 enhances susceptibility to acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Chemical and Drug Induced Liver Injury; Disease Su | 2012 |
Identification of early biomarkers during acetaminophen-induced hepatotoxicity by fourier transform infrared microspectroscopy.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cholesterol Esters; Cyto | 2012 |
Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antipyretics; Blood Glucose; | 2012 |
Caveats of using acetaminophen hepatotoxicity models for natural product testing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2012 |
Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Antipyretics; Biomarkers; Chemical a | 2013 |
N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Antipyretics; Aspartate Ami | 2014 |
Mouse liver protein sulfhydryl depletion after acetaminophen exposure.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2013 |
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, | 2012 |
Basic pain relievers. It's wise to use caution.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induc | 2012 |
Potential protective effect of honey against paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2012 |
An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
Topics: Acetaminophen; Animals; Antioxidants; Benzoquinones; Cell Death; Chemical and Drug Induced Liver Inj | 2013 |
Purified acetaminophen-glutathione conjugate is able to induce oxidative stress in rat liver mitochondria.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Respons | 2012 |
Integrating cellular metabolism into a multiscale whole-body model.
Topics: Acetaminophen; Allopurinol; Ammonia; Chemical and Drug Induced Liver Injury; Computational Biology; | 2012 |
Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2013 |
Evaluation of miR-122 and other biomarkers in distinct acute liver injury in rats.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Isocyanates; Liver; Male | 2013 |
Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antigens, CD1d; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP | 2013 |
Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Antido | 2012 |
Choice of the denominator in case population studies: event rates for registration for liver transplantation after exposure to NSAIDs in the SALT study in France.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studie | 2013 |
Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice.
Topics: Acetaminophen; Adolescent; Adult; Aged; Animals; Biomarkers; Calmodulin; Carbonic Anhydrases; Chemic | 2012 |
Elevated levels of the long pentraxin 3 in paracetamol-induced human acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Area Under Curve; Bacterial Infections; Biomar | 2013 |
Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2012 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2013 |
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj | 2013 |
Gas chromatography-mass spectrometry-based profiling of serum fatty acids in acetaminophen-induced liver injured rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Chemical and | 2014 |
TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner.
Topics: Acetaminophen; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; BH3 Interac | 2012 |
The effect of glucagon and cyclic adenosine monophosphate on acute liver damage induced by acetaminophen.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; | 2013 |
Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi).
Topics: Acetaminophen; Analysis of Variance; Animals; Antioxidants; Apium; Catfishes; Cations; Chemical and | 2013 |
Antihepatotoxic activity of a quantified Desmodium adscendens decoction and D-pinitol against chemically-induced liver damage in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2013 |
Hepatocyte tissue factor activates the coagulation cascade in mice.
Topics: Acetaminophen; Albumins; Analgesics, Non-Narcotic; Animals; Blood Coagulation; Blotting, Western; Ch | 2013 |
Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chemical an | 2013 |
Freshly isolated hepatocyte transplantation in acetaminophen-induced hepatotoxicity model in rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2012 |
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic | 2013 |
Assessment of emerging biomarkers of liver injury in human subjects.
Topics: Acetaminophen; Alanine Transaminase; Aryldialkylphosphatase; Biomarkers; Chemical and Drug Induced L | 2013 |
Therapeutic efficacy of Rosa damascena Mill. on acetaminophen-induced oxidative stress in albino rats.
Topics: Acetaminophen; Adenosine Triphosphatases; Analgesics, Non-Narcotic; Animals; Antioxidants; Blood Che | 2012 |
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylni | 2013 |
Reply: To PMID 22334567.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Failure, Acute; Macroph | 2013 |
Functional characteristics of macrophages in patients with acute liver failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Failure, Acute; Macroph | 2013 |
Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 2013 |
Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Blotting, Western; Cell Proliferation; Chemical and Drug Indu | 2013 |
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Topics: Acetaminophen; Adult; Alanine Transaminase; Biomarkers; Chemical and Drug Induced Liver Injury; Dise | 2013 |
Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug I | 2013 |
Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Central Nervous System Depressants; | 2002 |
A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Cell Adhesion Molecules; Chemical and Drug Induced | 2002 |
Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Diagnos | 2002 |
The effect of regular medication on the outcome of paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 2002 |
[Alcohol-paracetamol syndrome: a case report].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Mal | 2002 |
Comment: hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chronic | 2002 |
Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced | 2002 |
Ameliorative effect of Silene aprica on liver injuries induced by carbon tetrachloride and acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetr | 2002 |
Acetaminophen toxicity in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Dose-Respons | 2002 |
N-acetylcysteine for paracetamol poisoning: effect on prothrombin.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differe | 2002 |
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Chemical and D | 2002 |
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug | 2002 |
Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connective Tissue Growth Factor; Gen | 2002 |
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
Topics: Acetaminophen; Administration, Oral; Amitrole; Analgesics, Non-Narcotic; Animals; Bile; Catalase; Ch | 2002 |
Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; | 2002 |
Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Clodronic Acid | 2002 |
Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Blotting, Western; Chelating Agents; Chemical and Drug Induced Liver Injury; | 2003 |
Paracetamol hepatotoxicity at therapeutic doses.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cytochrome P | 2003 |
Paracetamol-induced hepatotoxicity at recommended dosage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anus Neoplasms; Brachytherapy; Carcinoma, Renal Cell; Chemi | 2003 |
Alcohol and acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Live | 2003 |
Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Excitatory | 2003 |
[Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, S | 2002 |
The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Anthocyanins; Antioxidants; Chemical and Drug Induced | 2003 |
[Effect of stilbene polymer (Gn-3) on experimental liver injuries in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Indu | 2001 |
[Effect of bicyclol on acetaminophen-induced hepatotoxicity: energetic metabolism and mitochondrial injury in acetaminophen-intoxicated mice].
Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Animals; Aspartate Aminotransferases | 2001 |
Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Animals; Antibodies, Blocking; Cell Line; Chemical and Drug Induced Liver Injury; Cyt | 2003 |
Regular medication and paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Data Collection; Dr | 2003 |
Successful treatment of acute hepatic injury caused by paracetamol intoxication in a late-referral patient by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2003 |
The protective effects of Propolis on hepatic injury and its mechanism.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Dose-Response | 2003 |
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2003 |
Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Gene Expression; Hea | 2003 |
Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver In | 2003 |
Glycosmis arborea extract as a hepatoprotective agent.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Body Weight; Carbon Tetrachlorid | 2003 |
Safe use of acetaminophen.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Canada; Chemical a | 2003 |
[Studies on protective effect of total flavonoids of Astragalus on liver damage induced by paracetamol].
Topics: Acetaminophen; Animals; Ascorbic Acid; Astragalus propinquus; Chemical and Drug Induced Liver Injury | 2001 |
[Protection against paracetamol-induced hepatic damage using total flavonoids of Astragalus].
Topics: Acetaminophen; Animals; Astragalus propinquus; Chemical and Drug Induced Liver Injury; Flavonoids; M | 2001 |
The difficulty of risk assessment for hepatic injury associated with supra-therapeutic acetaminophen use.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Dru | 2003 |
Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Aza | 2003 |
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemi | 2003 |
Paracetamol poisoning--impact of pack size restrictions.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug | 2003 |
Hepatoprotective and antioxidant activities of Tetracera loureiri.
Topics: Acetaminophen; Animals; Antioxidants; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Do | 2003 |
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
Topics: Acetaminophen; Animals; Cell Division; Chemical and Drug Induced Liver Injury; Colchicine; Cytochrom | 2003 |
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Bl | 2003 |
Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Capillaries; Chemical and Dr | 2004 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical | 2003 |
CHRONIC TOXICITY STUDIES ON PHENACETIN, N-ACETYL-P-AMINOPHENOL (NAPA) AND ACETYLSALICYLIC ACID ON CATS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Cats; Chemical and Drug | 1964 |
Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspart | 2003 |
Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antigens, CD; Blotting, Western; Chemical and Drug | 2003 |
Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of acetaminophen and its major metabolites in rabbit plasma and urine after a toxic dose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Calibration; Central Nervous Sy | 2003 |
Severe manifestations of coricidin intoxication.
Topics: Acetaminophen; Adolescent; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Chlorpheni | 2003 |
[Case report: habitual alcohol drinking caused early onset of acetaminophen-induced severe liver damage].
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Male | 2003 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2003 |
[Liquid paracetamol intoxication in the under-6s: changes in the toxic dose].
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury | 2003 |
Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amidines; Analgesics, Non-Narcotic; Anima | 2003 |
Chronic acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Gastric Byp | 2003 |
Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride Poisoning; Carcinogens; Chemi | 2003 |
[Fulminant hepatitis after a therapeutic dose of acetaminophen in a chronic alcoholic patient].
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2004 |
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2004 |
Gene expression profiling of rat livers reveals indicators of potential adverse effects.
Topics: Acetaminophen; Adenosine Triphosphate; Administration, Oral; Analgesics, Non-Narcotic; Animals; Chem | 2004 |
Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats.
Topics: Acetaminophen; Aizoaceae; Animals; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Phyt | 2004 |
Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fr | 2004 |
[Protective effects of shark hepatic stimulator substance against acute hepatic injury induced by acetaminophen in mice].
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; fas Receptor; Female; Gro | 2004 |
Acetaminophen intoxication and length of treatment: how long is long enough?--A comment.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Con | 2004 |
Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Centaurium; Chemical and Drug Induced Liver Injury; Liver; Male; Phytotherap | 2004 |
Silent acetaminophen-induced hepatotoxicity in febrile children: does this entity exist?
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2004 |
Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats.
Topics: Acetaminophen; Adenosine Triphosphatases; Animals; Ca(2+) Mg(2+)-ATPase; Chemical and Drug Induced L | 2004 |
S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics; Animals; Cell Membrane Permeability; Chemical and Drug Induced Liver Inju | 2004 |
Assessment of the protective potential of Premna tomentosa (L. Verbenaceae) extract on lipid profile and lipid-metabolizing enzymes in acetaminophen-intoxicated rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Li | 2004 |
Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Car | 2003 |
Hepatotoxicity possibly due to paracetamol with carbamazepine.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Carbamazepine; Chemical and Drug Induced Liver | 2004 |
Preventive effect of Thea sinensis melanin against acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Camellia sinensis; Chemical and Drug Induced Liver Inj | 2004 |
Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.
Topics: Acanthaceae; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotran | 2004 |
Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caf | 2004 |
Handle common pain reliever with care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 1997 |
Acetaminophen hepatotoxicity: NO to the rescue.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2004 |
The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding.
Topics: Acetaminophen; Animals; Antioxidants; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; | 2004 |
[Increased quality of life--your patient does not tolerate his medication?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug-Relate | 2004 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans | 2004 |
Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inhibit | 2005 |
Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Algorithms; Analges | 2004 |
Not enough relief from too much acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Live | 2004 |
Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Cell Separation; Chemical an | 2005 |
Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Animals; Bio | 2004 |
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Chemical and Drug Induced Liver I | 2004 |
[Severe toxic liver failure after acute poisoning with paracetamol, ferrous sulphate and naproxen].
Topics: Acetaminophen; Adult; Benzodiazepines; Chemical and Drug Induced Liver Injury; Female; Ferrous Compo | 2004 |
Intravenous administration of N-acetylcysteine: interference with coagulopathy testing.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Child; Female; Humans; | 2004 |
Acute acetaminophen intoxication in Taiwan: outcomes and risk factors.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2004 |
Unsuspected acetaminophen toxicity in a 58-day-old infant.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Humans; Inf | 2004 |
Intravenous N-acetylcysteine for children.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Hu | 2004 |
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzamides; Biotransformation; Chemical and Drug I | 2005 |
Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Acute-Phase Proteins; Adenoviridae; Animals; Carrier Proteins; Chemical and Drug Indu | 2005 |
Diverse antioxidants protect against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chromatography, High P | 2004 |
Fructose diphosphate attenuates the acetaminophen-induced liver injury in the rat evidence for involvement of nitric oxide.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2003 |
Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; alpha-Fetoproteins; | 2005 |
Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Car | 2005 |
Hepatoprotective and antioxidant effects of Alnus japonica extracts on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alnus; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dose-Response R | 2004 |
Hepatoprotective effects of the water extract from adzuki bean hulls on acetaminophen-induced damage in rat liver.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injur | 2004 |
Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.
Topics: Acetaminophen; Aflatoxin B1; Albumins; Animals; Benzoquinones; Blotting, Western; Carbon Tetrachlori | 2005 |
Acetaminophen toxicity revisited: is drug-induced hepatotoxity immune mediated?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Humans; Ki | 2005 |
Oral or intravenous N-acetylcysteine for acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Humans; | 2005 |
Protective effect of Sargassum polycystum (brown alga) against acetaminophen-induced lipid peroxidation in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipid Peroxidation; Phytotherapy; Pl | 2005 |
Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; beta Carotene; Chemical and Drug Ind | 2005 |
A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aspartate Aminotransferases; Chemical and Drug Ind | 2005 |
Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fe | 2005 |
Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Chemical and Drug Induced Liver | 2005 |
Proteomic identification of potential susceptibility factors in drug-induced liver disease.
Topics: Acetaminophen; Affinity Labels; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Aff | 2005 |
Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration.
Topics: Acetaminophen; Acetyltransferases; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug I | 2005 |
Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lamiaceae; Liver Diseases; Male; Mit | 2005 |
A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Benzoquinones; Chemical and Drug Induced Liver | 2005 |
Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alanine Transaminase; Analge | 2005 |
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, We | 2006 |
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Nucleus; Chemical and Drug Induced | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Chemistry and hepatoprotective activity of an active fraction from Barleria prionitis Linn. in experimental animals.
Topics: Acanthaceae; Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug I | 2005 |
A new acetaminophen nomogram with a different purpose.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2005 |
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-N | 2005 |
Effect of Sargassum polycystum (Phaeophyceae)-sulphated polysaccharide extract against acetaminophen-induced hyperlipidemia during toxic hepatitis in experimental rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2005 |
Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice.
Topics: Acetaminophen; Amaranth Dye; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Li | 2006 |
Antioxidant effect of Sargassum polycystum (Phaeophyceae) against acetaminophen induced changes in hepatic mitochondrial enzymes during toxic hepatitis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2005 |
Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2006 |
Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chromatogr | 2006 |
Acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2005 |
Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2006 |
[The influence of the dose, time since ingestion and concentration of the xenobiotic on the clinical state and severity of liver damage with patients intoxicated with paracetamol].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarke | 2005 |
Role of caspases in acetaminophen-induced liver injury.
Topics: Acetaminophen; Amino Acid Chloromethyl Ketones; Analgesics, Non-Narcotic; Animals; Caspase Inhibitor | 2006 |
Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Alcohol Drinking; Austr | 2005 |
Increased hepatotoxicity of acetaminophen in Hsp70i knockout mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2006 |
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Analgesics; Animals; Chemical and Drug Induced | 2006 |
Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70.
Topics: Acetaminophen; Alanine Transaminase; Ammonia; Analgesics, Non-Narcotic; Animals; Anti-Ulcer Agents; | 2006 |
Protective effect of crude extract from Wedelia paludosa (Asteraceae) on the hepatotoxicity induced by paracetamol in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2006 |
Effect of platelet-activating factor (PAF) receptor antagonist (BN52021) on acetaminophen-induced acute liver injury and regeneration in rats.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetaminophen; Analysis of Variance; Animals; Apopto | 2006 |
Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Deoxyribonuc | 2006 |
Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Genetic | 2006 |
Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Melatonin protects on toxicity by acetaminophen but not on pharmacological effects in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Body Temperature; Cell Survival; Che | 2006 |
Paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Blood Glucose; Chemical and Drug Ind | 2006 |
Endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 2006 |
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Fluorescen | 2006 |
Acetaminophen alert.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug Overdose; Humans | 2006 |
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2006 |
Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glycation End Products, Advanced; In | 2006 |
Alterations in the rat serum proteome during liver injury from acetaminophen exposure.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2006 |
Hepatoprotective activity of Hemidesmus indicus R. br. in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 2006 |
Drug-related hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug | 2006 |
[Case report of repeated acetaminophen overdosing with various symptoms].
Topics: Abdominal Pain; Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Disseminated Intravasc | 2006 |
Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analysis of Variance; Animals; Chemical and Drug Induced Liver | 2006 |
Neutrophil depletion protects against murine acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy, Needle; Blotting, Western; Chemical and Drug I | 2006 |
How relevant are neutrophils for acetaminophen hepatotoxicity?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug | 2006 |
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and | 2006 |
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chemical and Drug In | 2006 |
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anthracenes; Apoptosis; Blot | 2006 |
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, M | 2006 |
Severe hepatotoxicity after therapeutic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2006 |
Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 2006 |
Comment on "endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver Diseas | 2006 |
Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion.
Topics: Acetaminophen; Animals; Antioxidants; Biphenyl Compounds; Bupleurum; Carbon Tetrachloride; Cells, Cu | 2006 |
Adverse reaction from use of intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug | 2006 |
Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug | 2007 |
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Blotting, Western; Chemical and Dru | 2007 |
Paracetamol: are therapeutic doses entirely safe?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Funct | 2006 |
Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2006 |
Acetaminophen induces ER dependent signaling in mouse liver.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Ove | 2007 |
A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Ca | 2007 |
Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Body Temperature; Cell Count; Cell Divi | 2007 |
Efficacy of Sargassum polycystum (Phaeophyceae) sulphated polysaccharide against paracetamol-induced DNA fragmentation and modulation of membrane-bound phosphatases during toxic hepatitis.
Topics: Acetaminophen; Adenosine Triphosphatases; Animals; Antioxidants; Cations; Chemical and Drug Induced | 2007 |
Hepatoprotective effects of Chai-Hu-Ching-Kan-Tang on acetaminophen-induced acute liver injury in rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Safety of recommended doses of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2007 |
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antibodies; Arginase; Biomarkers; Chemical and Drug Induced Liver Injury; Di | 2007 |
More blood tests in paracetamol overdose?
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 2007 |
Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liv | 2007 |
Safety and pharmacokinetics of paracetamol following intravenous administration of 5 g during the first 24 h with a 2-g starting dose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Blood Cell Count; Blood Pressure; | 2007 |
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.
Topics: Acetaminophen; Aristolochic Acids; Cadmium Chloride; Cell Line; Cell Survival; Chemical and Drug Ind | 2007 |
Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Nar | 2007 |
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; | 2007 |
Platelet-activating factor inactivator (rPAF-AH) enhances liver's recovery after paracetamol intoxication.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetaminophen; Analgesics, Non-Narcotic; Animals; Ch | 2007 |
Patient-tailored acetylcysteine administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Ind | 2007 |
Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Ge | 2007 |
Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antibodies, Blocking; Biomar | 2007 |
Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antibodies, Monoclonal; Chemical and Drug Induced | 2007 |
Role of apoptosis in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Cell Membrane Permeability; Cells, Cultured; Chemical and Drug In | 2007 |
Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Disease Models, Animal; D | 2007 |
Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.
Topics: Acetaminophen; Acyl-CoA Oxidase; Amidohydrolases; Animals; Anticholesteremic Agents; Cell Adhesion M | 2007 |
Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Calotropis; Chemical and Drug Induced Liver Injury | 2007 |
The influence of small doses of paracetamol on rabbit liver.
Topics: 3-Hydroxybutyric Acid; Acetaminophen; Acetoacetates; Administration, Oral; Alanine Transaminase; Ana | 2007 |
Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Animals; Biotransformation; Carbon Tetrachloride; Chemical | 2007 |
Paracetamol overdose as a result of dental pain requiring medical treatment - two case reports.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidotes; Chemical and Drug Ind | 2007 |
Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dose-Response Relation | 2007 |
Protective role of Raphanus sativus root extract on paracetamol-induced hepatotoxicity in albino rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2007 |
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; De | 2008 |
Clinical policy: critical issues in the management of patients presenting to the emergency department with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eme | 2007 |
[Liver toxicity of paracetamol].
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Live | 2007 |
Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Ami | 2007 |
Clinical excellence exemplar.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2007 |
Comparison of rocket and crossed immuno-electrophoresis assays for determination of the level of actin complexing of Gc globulin.
Topics: Acetaminophen; Actins; Calibration; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorb | 2007 |
Etiologies of acute liver failure: location, location, location!
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Global Health; Hepa | 2007 |
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Indu | 2008 |
Efficacy of Raphanus sativus in the treatment of paracetamol-induced hepatotoxicity in albino rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Catalase; Chemical and Drug Induced Liver Injury; | 2007 |
Platelet activating factor (PAF) antagonism with ginkgolide B protects the liver against acute injury. importance of controlling the receptor of PAF.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2008 |
Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects.
Topics: Acetaminophen; Adult; Alcohol Drinking; Alcoholism; Analgesics, Non-Narcotic; Biomarkers, Pharmacolo | 2007 |
[Clinical value of estimated half-life in paracetamol poisoning as a complement to Rumack's nomogram].
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Half-Life; Huma | 2007 |
[Acetaminophen: hepatotoxicity at therapeutic doses and risk factors].
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2007 |
Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2008 |
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidan | 2008 |
alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Catec | 2008 |
Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Animals; Chemical and | 2008 |
Protective effect of Phyllanthus polyphyllus on acetaminophen induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antioxidants; Biomarkers; Ca | 2008 |
Does the patient history predict hepatotoxicity after acute paracetamol overdose?
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Aspartate Amino | 2008 |
Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Etha | 2008 |
What's in a name?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Chemical and Drug Induced Liver Injury; Hemoc | 2008 |
Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Antiox | 2008 |
Serum urea concentration and the risk of hepatotoxicity after paracetamol overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Blood Glucose; Chemical and Drug Induced | 2008 |
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
Topics: Acetaminophen; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cytosol; Genotype; Gluta | 2008 |
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induc | 2008 |
Key features of the patient-tailored N-acetylcysteine protocol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Ca | 2008 |
Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and | 2008 |
Inpatient admissions for drug-induced liver injury: results from a single center.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Chemical and Drug Induced Live | 2008 |
Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury | 2008 |
Comment on "Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2008 |
Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach.
Topics: Acetaminophen; Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Antioxida | 2008 |
Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Ami | 2008 |
Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Biomarkers; Cell Proliferati | 2008 |
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2008 |
Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2008 |
Ranitidine, acetaminophen, and hepatotoxicity.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Male; Ranitidine | 1984 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer?
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Electron Transpor | 1981 |
Ethanol in paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Ethanol; Humans; Male; Middle Aged | 1983 |
Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Glucuronates; Glutathion | 1984 |
Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals.
Topics: 1-Propanol; Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug | 1984 |
Effect of acetaminophen toxicity on erythrocyte osmotic fragility in the Fisher rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1984 |
Interaction between acetaminophen and organophosphates in mice.
Topics: Acetaminophen; Animals; Brain; Chemical and Drug Induced Liver Injury; Chlorpyrifos; Cholinesterases | 1984 |
Ulcer, back pain, and jaundice in an alcoholic.
Topics: Acetaminophen; Adult; Alcoholism; Back Pain; Chemical and Drug Induced Liver Injury; Dextropropoxyph | 1983 |
Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein.
Topics: Acetaminophen; Animals; Catechin; Chemical and Drug Induced Liver Injury; Deanol; Dimethyl Sulfoxide | 1980 |
Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Benzopyrenes; Chemical and Drug | 1982 |
Acetaminophen hepatotoxicity. An alternative mechanism.
Topics: Acetaminophen; Alcoholism; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Crice | 1983 |
Role of microsomal drug detoxifying enzyme systems in paracetamol induced liver injury in rats.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Glucose-6-Phosphat | 1983 |
Ranitidine and acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; | 1984 |
Influence of acetaminophen-induced hepatic necrosis on the pharmacokinetics of levonorgestrel.
Topics: Acetaminophen; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Contracepti | 1983 |
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury | 1983 |
Paracetamol overdose as a cause of non-A, non-B hepatitis.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; F | 1984 |
Apparent potentiation of hepatotoxicity from small doses of acetaminophen by phenobarbital.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Humans; Middle Aged; | 1984 |
Elevated SGOT/SGPT ratio in alcoholic patients with acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr | 1984 |
Anion gap acidosis with hypoglycemia in acetaminophen toxicity.
Topics: Acetaminophen; Acid-Base Imbalance; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced | 1984 |
Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice.
Topics: Acetaminophen; Animals; Anisoles; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; | 1984 |
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; C | 1984 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Risk; Suicide, Attemp | 1984 |
[Paracetamol poisoning--clinical aspects and pharmacokinetics].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcohol Drinking; Chemical and Drug Induced Liver Injury; | 1983 |
Acute liver failure and encephalopathy in a 15-month-old infant.
Topics: Acetaminophen; Acute Disease; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Diagnosis, Dif | 1983 |
[Acetaminophen poisoning in children: a serious error in medical prescription].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Fever; Humans; Iatro | 1983 |
Histological & ultrastructural alterations in the livers of albino rats after prolonged administration of paracetamol.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; | 1983 |
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Carbocysteine; Chemical and Drug Induced Liver Injury; Crice | 1983 |
Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice.
Topics: Acetaminophen; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Erythrocytes; Liver; | 1983 |
[Pharmacokinetics and metabolism of acetaminophen in normal, alcoholic and cirrhotic subjects].
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Kinetics; Liver Ci | 1983 |
Fatal acetaminophen toxicity in a 2-year-old.
Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; H | 1983 |
Hepatic lipid peroxidation: caused by acute drug intoxication, prevented by liposomal glutathione.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hydrocarbons; Lipid Per | 1983 |
Probable acetaminophen toxicity in an 18-month-old infant due to repeated overdosing.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Infant; Liver Function Tests | 1984 |
[The significance of lipid peroxidation in drug-induced liver damage].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Lipid Peroxides | 1984 |
Quantitative liver functions after administration of allyl alcohol to rats.
Topics: 1-Propanol; Acetaminophen; Acrolein; Animals; Anisoles; Chemical and Drug Induced Liver Injury; Fema | 1984 |
Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Ethanol; Hu | 1984 |
Enhancement of paracetamol induced hepatotoxicity by prior treatment with carboxymethylcellulose.
Topics: Acetaminophen; Animals; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Gluta | 1984 |
[Rare side effects following paracetamol poisoning].
Topics: Acetaminophen; Acidosis; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Methemo | 1984 |
Problems in the necropsy diagnosis of alcoholic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D | 1984 |
Acetaminophen hepatotoxicity associated with alcoholic pancreatitis.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Pancreatitis; Substance-R | 1984 |
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat.
Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Ch | 1984 |
Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cystine | 1984 |
Free radicals in vivo. Covalent binding to lipids.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1984 |
Factors contributing to mortality in paracetamol-induced hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Critical Care; Female; Hepatic Encepha | 1981 |
Paracetamol--induced hepatic failure.
Topics: Acetaminophen; Adult; Aged; Antidotes; Chemical and Drug Induced Liver Injury; Child; Hemoperfusion; | 1981 |
Factors contributing to mortality in paracetamol-induced hepatic failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Reagent Kits, Diagnostic | 1981 |
Paracetamol-induced hepatic failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Half-Life; Humans | 1981 |
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Femal | 1982 |
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; M | 1982 |
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Humans; Male | 1982 |
Platelet adhesiveness to glass beads in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Glass; Hemoperfusion; Hepati | 1982 |
Acetaminophen poisoning in infancy.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Infant; Liver Function Tests; | 1983 |
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Glucuronates; | 1983 |
Prevention of acetaminophen and cocaine hepatotoxicity in mice by cimetidine treatment.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Co | 1983 |
Covalent binding theory for acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Macromolecular Substances; Pr | 1983 |
The mechanism of paracetamol-induced hepatotoxicity: implications for therapy.
Topics: Acetaminophen; Antidotes; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; | 1983 |
[Hepatic lesion caused by acetaminophen. Apropos of a case with unusual portal involvement].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Inflammation; Male; Middle Aged; Necr | 1983 |
Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hypergl | 1983 |
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki | 1983 |
Acetaminophen and its toxicity.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Cats; Chemical and Drug Induced Liver I | 1983 |
[Drug-induced liver damage; new aspects on its mechanism].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Re | 1980 |
Drug data: drug-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relat | 1982 |
Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Glu | 1982 |
Late presentation of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Middle | 1982 |
Late presentation of acetaminophen hepatotoxicity. An unresolved problem.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Suicide, Attempted; Time Factors; Uni | 1982 |
Paracetamol self-poisoning: diagnosis, management, and outcome.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Australia; Chemical and Drug | 1982 |
The hepatotoxicity of paracetamol--clinical aspects.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans | 1982 |
Anti-LSP antibodies in acute liver disease.
Topics: Acetaminophen; Acute Disease; Autoantibodies; Chemical and Drug Induced Liver Injury; Hepatitis, Alc | 1982 |
Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Gluta | 1982 |
Cimetidine and acetylcysteine as antidote for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytoch | 1982 |
Studies on the effects of L-ascorbic acid on acetaminophen-induced hepatotoxicity. II. An in vivo assessment in mice of the protection afforded by various dosage forms of ascorbate.
Topics: Acetaminophen; Animals; Ascorbic Acid; Capsules; Chemical and Drug Induced Liver Injury; Liver; Male | 1982 |
Ethylesterases as indicators of liver damage. I. Studies on malathion carboxylesterases.
Topics: Acetaminophen; Adult; Aged; Aging; Animals; Aspartate Aminotransferases; Butylated Hydroxyanisole; C | 1982 |
[Acute lesion of the liver by paracetamol (a review of the literature)].
Topics: Acetaminophen; Acute Disease; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Inter | 1982 |
Paracetamol poisoning--hepatic protection by n-acetylcysteine.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cystine; Humans; Male; Necrosis | 1982 |
Acetaminophen poisoning and its treatment.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans | 1982 |
Protection against acetaminophen-induced hepatotoxicity by prior treatment with fenitrothion.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fenitrothion; Glutathione; Liver; Ma | 1982 |
Experimental study on paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Rats | 1982 |
Bacteraemia in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H | 1982 |
Iatrogenic toxic liver disease.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Enzyme Induction; | 1982 |
Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat.
Topics: Acetaminophen; Alcoholism; Aminopyrine N-Demethylase; Animals; Aspartate Aminotransferases; Chemical | 1981 |
Liver failure in an infant.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Infant | 1981 |
Acetaminophen as an aspirin substitute: is it safer?
Topics: Acetaminophen; Aspirin; Biotransformation; Cardiomyopathies; Chemical and Drug Induced Liver Injury; | 1980 |
Long-term ingestion of paracetamol and liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1980 |
Disturbances of lactate metabolism in patients with liver damage due to paracetamol overdose.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Viral, Human; Human | 1981 |
A disarmed world.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatitis, Animal; Male; Mice; Mice, | 1981 |
Liver failure in an infant.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans; Infa | 1980 |
Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Pois | 1981 |
Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatoxicity.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Ethanol; Glutathi | 1981 |
Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Body Temperature; Chemical and Drug Induced Liver Injury; He | 1981 |
The influence of fasting on the susceptibility of mice to hepatotoxic injury.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Enzy | 1981 |
Studies on the effects of L-ascorbic acid on acetaminophen-induced hepatotoxicity. 1. Inhibition of the covalent binding of acetaminophen metabolites to hepatic microsomes in vitro.
Topics: Acetaminophen; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Cricetinae; Female; I | 1981 |
Cimetidine protects against acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and | 1981 |
Raised serum biliverdin in hepatic necrosis.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Bilirubin; Biliverdine; Chemical and Drug Induced Live | 1981 |
Quantification of the joint effects of mixtures of hepatotoxic agents: evaluation of a theoretical model in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Indu | 1981 |
Circulating immune complexes in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Antigen-Antibody Complex; Chemical and Drug Induced Liver In | 1981 |
Liver injury due to drugs.
Topics: Acetaminophen; Anti-Bacterial Agents; Antitubercular Agents; Cathartics; Chemical and Drug Induced L | 1981 |
Cimetidine protects against acetaminophen hepatoxicity.
Topics: Acetaminophen; Adolescent; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Guan | 1981 |
Liaison with industry in the provision of essential information for the management of poisoning.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug I | 1980 |
Alcoholism, nonprescription drug and hepatotoxicity. The risk from unknown acetaminophen ingestion.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Femal | 1981 |
Massive cerebral edema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompression.
Topics: Acetaminophen; Adolescent; Brain Edema; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1981 |
[Acute hepatocellular damage due to paracetamol].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver | 1981 |
Overview of alkylation and peroxidation mechanisms in acute lethal hepatocellular injury by chemically reactive metabolites.
Topics: Acetaminophen; Alkylation; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chem | 1981 |
Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1980 |
Acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Necrosis | 1980 |
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Injections, Intraveno | 1980 |
Predicting outcome of paracetamol poisoning by use 14C-aminopyrine breath test.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aminopyrine; Breath Tests; Carbon Radioisotopes; Chemical an | 1980 |
Acetaminophen associated hepatic injury, Report of two cases showing unusual portal tract reactions.
Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Alcoholism; Biopsy; Chemical and Drug Indu | 1980 |
Role of glutathione in the protective effect of hypothyroidism against chemically induced hepatic injury: new or old associations?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hypothyroidism; Rats; T | 1980 |
[Phenacetin or paracetamol?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Humans; Kidney Papillary | 1980 |
Developmental susceptibility to acetaminophen toxicity.
Topics: Acetaminophen; Aging; Animals; Chemical and Drug Induced Liver Injury; Female; Injections, Intraperi | 1980 |
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis | 1980 |
Intravenous N-acetylcysteine for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Hu | 1980 |
[H. U. Zollinger: 25 years of phenacetin abuse].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Legislation, Drug; P | 1980 |
[Relationship between GSH depletion and "in vitro" lipoperoxidative processes in liver of rats intoxicated with paracetamol (author's transl)].
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Glutathione; L | 1980 |
Paracetamol and chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Cirrhosis, | 1980 |
[Influence of pretreatment with carbon tetrachloride on paracetamol-induced hepatotoxicity].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1980 |
Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Kinetics; Liver; Liver Diseases; Mal | 1995 |
Acetaminophen-induced hepatotoxicity: protection by enzyme inhibition.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 1995 |
Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1995 |
A protective effect of glutathione-dextran macromolecular conjugates on acetaminophen-induced hepatotoxicity dependent on molecular size.
Topics: Acetaminophen; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chemic | 1994 |
Abnormal serum transaminases following therapeutic doses of acetaminophen in the absence of known risk factors.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; C | 1995 |
Effect of Teucrium stocksianum on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Li | 1995 |
Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 1995 |
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
Topics: Acetaminophen; Animals; Cadmium Poisoning; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1995 |
Acetaminophen hepatotoxicity, fasting, and ethanol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Hypoxia; Liver; Risk Factors | 1995 |
Acetaminophen hepatotoxicity, fasting, and ethanol.
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Fasting; Humans; Nutrition | 1995 |
Spontaneous remission of paracetamol induced acute renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Female; Huma | 1995 |
[Protective effect of the fulvotomentosides on paracetamol-induced hepatotoxicity in mice].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glutathione; | 1995 |
[Effects of drugs on the liver. A review illustrated with 3 clinical cases].
Topics: Acetaminophen; Adult; Aged; Androgens; Chemical and Drug Induced Liver Injury; Denmark; Disulfiram; | 1994 |
[Fulminant hepatitis induced by paracetamol at a therapeutic dose favoured by the ingestion of enzyme inducers in a patient with liver cirrhosis].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Depressive D | 1995 |
Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Deferoxamine; | 1995 |
[Paracetamol poisoning at a department of hepatology].
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Denmark; Female; Hep | 1995 |
Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Chemical and Drug Induced Liver Injury; Glutathione; | 1994 |
Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome | 1995 |
The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Chemical a | 1995 |
Protective effect of diltiazem against acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Survival; Chemical and Drug Induced Liver Inju | 1995 |
Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism.
Topics: Acetaminophen; Animals; Calcium; Carmustine; Chemical and Drug Induced Liver Injury; Cytosol; Energy | 1995 |
Studies on protective effect of Cyperus scariosus extract on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Car | 1995 |
The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction.
Topics: Acetaminophen; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Human | 1995 |
Potentiation of acetaminophen hepatotoxicity in a child with mercury poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Drug Synergism; Female; Humans; Mercur | 1994 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Proto | 1993 |
Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Eval | 1995 |
An experimental study on the disturbance of liver circulation and the change of hemorrheology in dogs with acute liver damage.
Topics: Acetaminophen; Animals; Blood Viscosity; Chemical and Drug Induced Liver Injury; Dogs; Female; Hemor | 1994 |
Effect of ursodeoxycholic acid on in vivo and in vitro toxic liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Car | 1994 |
Acetaminophen ingestion in childhood--cost and relative risk of alternative referral strategies.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child, Preschool; Cost-Benefit Analysis; Drug | 1994 |
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1994 |
Alcohol and analgesics--mix extraordinaire.
Topics: Acetaminophen; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug | 1994 |
[An preliminary study on hepato-protective action of seed oil of Hippophae rhamnoides L. (HR) and mechanism of the action].
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug | 1994 |
[Protection against experimental hepatic injury by fengxiang yigankang capsule].
Topics: Acetaminophen; Alanine Transaminase; Animals; Capsules; Carbon Tetrachloride Poisoning; Chemical and | 1994 |
Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug I | 1994 |
[Cytoprotective effect of neurotensin on acetaminophen induced liver injury in relation to glutathione system].
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; DNA; Free Radical S | 1994 |
Association of acetaminophen hepatotoxicity with fasting and ethanol use.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Chemical and Drug Induced Live | 1994 |
Adverse reactions to over-the-counter analgesics taken for therapeutic purposes.
Topics: Acetaminophen; Alcoholism; Analgesics; Chemical and Drug Induced Liver Injury; Ethanol; Fasting; Hum | 1994 |
Hepatoprotective effects of Taiwan folk medicine: wedelia chinensis on three hepatotoxin-induced hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotr | 1994 |
Baseline liver function tests following acetaminophen ingestion. What is the utility?
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Li | 1994 |
[Effects of paracetamol on glutathione S-transferase activity in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Butylated Hydroxyanisole; Chemical and Drug Induced Li | 1993 |
[Sodium ferulate alleviated paracetamol-induced liver toxicity in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Coumaric Acids | 1994 |
Protective and therapeutic effects of ban-zhi-lian on hepatotoxin-induced liver injuries.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Pois | 1994 |
Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury.
Topics: Acetaminophen; Biopsy; Cell Count; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hu | 1994 |
Parental and medical over-administration of acetaminophen causing lethal hepatotoxicity in a 10-year-old.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Fatal Outcome; Female; | 1994 |
Do thyroid hormones promote hepatotoxicity to acetaminophen?
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Goiter; Headache; Humans; | 1994 |
Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carboxylic Es | 1993 |
Protective effect of Artemisia scoparia extract against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1993 |
Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases.
Topics: Acetaminophen; Acetylcysteine; Adult; Charcoal; Chemical and Drug Induced Liver Injury; Combined Mod | 1993 |
Andrographolide protects rat hepatocytes against paracetamol-induced damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Che | 1993 |
Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen overdosing.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Child, P | 1994 |
Attenuation of acetaminophen hepatitis by prostaglandin E2. A histopathological study.
Topics: 16,16-Dimethylprostaglandin E2; Acetaminophen; Acetylcysteine; Acute Disease; Animals; Chemical and | 1994 |
Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury | 1994 |
Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1993 |
Acute hepatic decompensation in an alcoholic.
Topics: Acetaminophen; Acute Disease; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Male; Midd | 1993 |
Effect of thiola on acetaminophen induced hepatic necrosis in mice.
Topics: Acetaminophen; Animals; Behavior, Animal; Chemical and Drug Induced Liver Injury; Drug Interactions; | 1993 |
The fatal paracetamol dosage--how low can you go?
Topics: Acetaminophen; Adolescent; Cause of Death; Chemical and Drug Induced Liver Injury; Dose-Response Rel | 1993 |
[A case of prolonged liver injury caused by low dose of acetaminophen--the involvement of other multiple drugs such as Proheparum and Mazulene-S was considered in this drug-induced hepatitis].
Topics: Acetaminophen; Adult; Azulenes; Bis-Trimethylammonium Compounds; Chemical and Drug Induced Liver Inj | 1993 |
Prednisolone stimulates hepatic glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glut | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav | 1993 |
Acetaminophen hepatotoxicity augmented by zidovudine.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Humans; Rats; Zidovu | 1993 |
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Biliary Tract; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 1993 |
Effect of colchicine on acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Colchicine; Free Radical Scavengers; | 1993 |
Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: comparison with carbon tetrachloride.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Interacti | 1993 |
Antagonism of acetaminophen hepatotoxicity by phospholipase A2 inhibitors.
Topics: Acetaminophen; Animals; Calcium; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlorpromazin | 1993 |
Development of an in vitro hepatotoxicity assay for assessing the effects of chronic drug exposure.
Topics: Acetaminophen; Amitriptyline; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hu | 1993 |
Increased metabolism of acetaminophen in chronically alcoholic patients.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dose-Response Relationship | 1993 |
Acetaminophen hepatotoxicity after a prolonged ingestion.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Te | 1993 |
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.
Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug In | 1993 |
Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Membrane; Chelating Agents; Chemical and Drug | 1993 |
Inhibitory effect of cold stress against acetaminophen-induced hepatic injury in B6C3F1 and ICR mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Body Temperature; Chemical and Drug Induced Liver Inju | 1995 |
Protective effects of Osbeckia octandra against paracetamol-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 1995 |
[Plasma levels of alanine aminotransferase in experimental liver necrosis induced by overdosage of paracetamol in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Female; Liver; | 1995 |
Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug In | 1995 |
Acetaminophen, NSAIDs and alcohol.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 1996 |
Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced L | 1995 |
Mitochondrial ATPase: a target for paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Animals; Aspartate Aminotransferases | 1995 |
Cholestasis as a liver protective factor in paracetamol acute overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cholestasi | 1995 |
Effects of phenobarbital on aniline metabolism in primary liver cell culture of rats with ethionine-induced liver disorder.
Topics: Acetaminophen; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Chemical and Drug Induced | 1996 |
Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 1996 |
The influence of antagonists of poly(ADP-ribose) metabolism on acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 1996 |
Immunochemical detection of drug-protein adducts in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver | 1996 |
Is activation of lysosomal enzymes responsible for paracetamol-induced hepatotoxicity and nephrotoxicity?
Topics: 4-Nitrophenylphosphatase; Acetaminophen; Amino Acids; Analgesics, Non-Narcotic; Animals; Cathepsin D | 1996 |
Sex- and age-dependent acetaminophen hepato- and nephrotoxicity in Sprague-Dawley rats: role of tissue accumulation, nonprotein sulfhydryl depletion, and covalent binding.
Topics: Acetaminophen; Age Factors; Animals; Chemical and Drug Induced Liver Injury; Female; Kidney; Kidney | 1996 |
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Dru | 1996 |
Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; India; Li | 1995 |
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimerization; DNA; Female; Gene Expr | 1996 |
The enhanced effect of parenteral nutrition on hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1996 |
Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Dru | 1996 |
Protective effect of S-(1,2-dicarboxyethyl)glutathione, an intrinsic tripeptide in liver, heart and lens, and its esters on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemical and Drug Ind | 1996 |
Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation.
Topics: Acetaminophen; Actins; Adult; Aged; Amanita; Autoimmune Diseases; Biomarkers; Cell Differentiation; | 1996 |
Factors responsible for continuing morbidity after paracetamol poisoning in Chinese patients in Hong Kong.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Asian People; C | 1996 |
Increased resistance to acetaminophen-induced hepatotoxicity in retrovirus-infected mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 1996 |
Should a patient who attempted suicide receive a liver transplant?
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Ethicists; | 1996 |
Differential diagnosis of postoperative liver failure in a 12-year-old child.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Chemical and Drug Induced Liver In | 1996 |
Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase-inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid L-methionine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants | 1997 |
Pediatric subacute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 1997 |
Clinical consequences of nonnarcotic analgesic use.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Inj | 1997 |
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Ch | 1997 |
Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical a | 1996 |
Acute psychosis associated with acetaminophen overdose.
Topics: Acetaminophen; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; HIV Sero | 1997 |
Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylas | 1997 |
Paracetamol-induced cholestatic and granulomatous liver injuries.
Topics: Acetaminophen; Acute Disease; Adult; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcot | 1997 |
Calcium-dependent DNA damage and adenosine 3',5'-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Calcium; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury | 1997 |
Expression of liver functions following sub-lethal and non-lethal doses of allyl alcohol and acetaminophen in the rat.
Topics: 1-Propanol; Acetaminophen; Acute-Phase Proteins; Animals; Biomarkers; Chemical and Drug Induced Live | 1997 |
A jaundiced look at the management of hepatitis?
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatiti | 1997 |
Should methionine be added to every paracetamol tablet?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Res | 1997 |
Paracetamol-induced pancreatitis and fulminant hepatitis in a hemodialysis patient.
Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury | 1997 |
Effects of fructose-induced hypertriglyceridemia on hepatorenal toxicity of acetaminophen in rats: role of pharmacokinetics and metabolism of acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose | 1997 |
Acetaminophen toxicity in an urban county hospital.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Chemical and Drug | 1997 |
2-Methyl-thiazolidine-2,4-dicarboxylic acid as prodrug of L-cysteine. Protection against paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Liver | 1997 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea | 1997 |
[Massive increase in transaminases and thrombocytopenia. Acute drug-induced toxic hepatitis (probable culprit: paracetamol)].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Diagnosis, Differen | 1997 |
Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction.
Topics: Acetaminophen; Amphetamine; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced | 1997 |
Acetaminophen overdose with therapeutic intent.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Patient Selection; Research Design; R | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Dise | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1998 |
[Fatal acute liver damage caused by a therapeutic dose of paracetamol].
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response R | 1998 |
Possible role of glutathione in prevention of acetaminophen-induced hepatotoxicity enhanced by fish oil in male Wistar rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 1998 |
Esculetin prevents liver damage induced by paracetamol and CCL4.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1998 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
Ethanol-acetaminophen cocktail: the debate continues!
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Retrospect | 1998 |
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 1998 |
Severe idiosyncratic acute hepatic injury caused by paracetamol.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; B | 1998 |
Role of cimetidine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Humans; L | 1998 |
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Alleles; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induc | 1998 |
Temporal variation in hepatotoxicity and metabolism of acetaminophen in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chromatogr | 1998 |
Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol-induced hepatic damage in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Plant Extracts; Rats; Rats, Wi | 1998 |
Paracetamol-induced liver toxicity after intravenous administration.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver In | 1998 |
Potentiation of acetaminophen hepatotoxicity and mortality by doxapram in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Central Nervous System Stimulants; Chemical and Dr | 1998 |
[Paracetamol-induced tubulointerstitial nephritis in a chronic alcoholic patient].
Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Chr | 1998 |
Protective effect of the mold Monascus anka against acetaminophen-induced liver toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aniline Hydroxylase; Animals; Ascomycota; Aspartate Aminotr | 1998 |
[Protective effect of interleukin-1 beta on acetaminophen induced liver damage in mice].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Interleukin-1; Interleu | 1997 |
Differential chemoprotection against acetaminophen-induced hepatotoxicity by latentiated L-cysteines.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Disaccharides; Glutathione | 1998 |
[Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Drug | 1998 |
Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Coenzymes; Cys | 1998 |
Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats.
Topics: Acarbose; Acetaminophen; Alkylating Agents; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride | 1999 |
Acarbose and acetaminophen--a dangerous combination?
Topics: Acarbose; Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride Poisoning; Chemical | 1999 |
Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 1998 |
Studies on protective effect of DA-9601, Artemisia asiatica extract, on acetaminophen- and CCl4-induced liver damage in rats.
Topics: Acetaminophen; Animals; Artemisia; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I | 1998 |
Gastric emptying in rats with acetaminophen-induced hepatitis.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 1998 |
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical a | 1998 |
Deaths from low dose paracetamol poisoning. Several issues were not considered in the article.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Death, Sudden; Huma | 1998 |
Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cell Division; Chemical and Drug Induced Li | 1999 |
Effect of orally administered reduced- and oxidized-glutathione against acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Che | 1998 |
Effect of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'- dicarboxylate (DDB) on chemical-induced liver injury.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diox | 1999 |
Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Isoniazid; Liver Function Te | 1998 |
Paracetamol for fever in children: high time for systematic reviews of the evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Evidence-Bas | 1999 |
[ACC in liver failure].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Huma | 1999 |
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 1999 |
Early metabolic acidosis and coma after acetaminophen ingestion.
Topics: Acetaminophen; Acidosis; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Live | 1999 |
Routine screening for acetaminophen (APAP) toxicity of patients requesting alcohol detoxification.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; | 1999 |
Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 1999 |
Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 1999 |
Ameliorative effect of an urinary preparation on acetaminophen and D-galactosamine induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Humans; | 1999 |
Characteristics and risk factors of acetaminophen-induced hepatitis in Taiwan.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 1999 |
Hypothyroidism protects rat liver from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chemical and Drug Induced Li | 1999 |
Acetaminophen hepatotoxicity without intentional overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Risk Factor | 1999 |
[Benzodiazepines metabolism in various models of experimental liver diseases].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Benzodiazepines; Chemical and Drug | 1999 |
[Acetaminophen hepatotoxicity in an alcohol addicted student. Case report].
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Child; Humans; Male | 1999 |
Nicotinamide and methionine reduce the liver toxic effect of methotrexate.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspart | 1999 |
Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Beh | 1999 |
Transformation of an acetaminophen toxicity nomogram to an artificial neural network.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Gastroin | 1999 |
The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticholesteremic Agents; Biotransformation; Blott | 1999 |
[No N-acetylcysteine in the absence of verified paracetamol intoxication].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug I | 1999 |
Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase.
Topics: Acetaminophen; Alcohol Dehydrogenase; Aminopyrine N-Demethylase; Analgesics, Non-Narcotic; Animals; | 1999 |
Childhood hepatotoxicity with paracetamol doses less than 150 mg/kg per day.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 1999 |
Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug I | 2000 |
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Cell Nucl | 2000 |
Prospective evaluation of mild to moderate pediatric acetaminophen exposures.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child, Preschool; F | 2000 |
Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
Topics: Acetaminophen; Adjuvants, Immunologic; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cattle; | 2000 |
Combination acetaminophen and doxapram potentiated hepatotoxicity in mouse primary cultured hepatocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Calcium; Cell Survival; C | 1999 |
Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.
Topics: Acetaminophen; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Chemokine CCL | 2000 |
Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Ove | 2000 |
Unintentional acetaminophen ingestion in children and the potential for hepatotoxicity.
Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; H | 2000 |
Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis.
Topics: Acetaminophen; Animals; Antidotes; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver I | 2000 |
Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Dru | 2000 |
Reduction in incidence of severe paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2000 |
Toxic acetaminophen doses are toxic or do you know where your acetaminophen is today?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Information Se | 2000 |
Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Glycerides | 2000 |
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemic | 2000 |
Protective effect of leaf extract of Ficus hispida Linn. against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2000 |
Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chromatography | 2000 |
Yang-Gan-Wan protects mice against experimental liver damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2000 |
Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Li | 2000 |
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cl | 2000 |
Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inhibit | 2000 |
Effect of liquid extract from fresh Abutilon indicum leaves and Allium cepa bulbs on paracetamol and carbontetrachloride induced hepatotoxicity.
Topics: Acetaminophen; Allium; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug In | 2000 |
Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Biotransformation; Chemical and Dru | 2000 |
Antioxidant and hepatoprotective effects of Acathopanax senticosus.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetr | 2000 |
Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose.
Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Benzoquinones; Chemical and Drug Induced | 2000 |
Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anticoagulants; Blood Coagulation; | 2000 |
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; DNA-Binding Pr | 2001 |
Safety of childhood acetaminophen overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdos | 2001 |
A comparison of the effect of nitroparacetamol and paracetamol on liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2001 |
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotrans | 2001 |
Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice.
Topics: Acetaminophen; Aldehydes; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; | 2001 |
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.
Topics: Acetaminophen; Acetylation; Alanine Transaminase; Aminophenols; Animals; Ascorbic Acid; Buthionine S | 2001 |
Idiosyncratic acute hepatitis caused by paracetamol in two patients with melanoma treated with high-dose interferon-alpha.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Antineoplastic Agents; Chemical and Drug Ind | 2001 |
Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bile; Chemical and Drug Induced Liver Injury; Colo | 2001 |
Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Asteraceae; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclin | 2001 |
Acute cholestatic hepatitis caused by a probable allergic reaction to paracetamol in an adolescent.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Ind | 2001 |
Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen-induced liver damage in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2001 |
Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Apopto | 2001 |
[Liver and renal tolerance to paracetamol: 3 g or 4 g per day?].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2001 |
Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2001 |
Eotaxin expression and eosinophil infiltrate in the liver of patients with drug-induced liver disease.
Topics: Acetaminophen; Adult; Blood Cell Count; Chemical and Drug Induced Liver Injury; Chemokine CCL11; Che | 2001 |
Pediatric acetaminophen overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relati | 2001 |
Evaluation of hepatoprotective activity of legumes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2001 |
Hepatoprotective activity of Cassia fistula leaf extract.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2001 |
Retinol potentiates acetaminophen-induced hepatotoxicity in the mouse: mechanistic studies.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Catalysis; Chemical and Dr | 2001 |
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ber | 2000 |
Mechanism of protection by S-(1,2-dicarboxyethyl)glutathione triester against acetaminophen-induced hepatotoxicity in rat hepatocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2001 |
Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical a | 2001 |
[Protective action of corynoline, acetylcorynoline and protopine against experimental liver injury in mice].
Topics: Acetaminophen; Alanine Transaminase; Alkaloids; Animals; Benzophenanthridines; Berberine Alkaloids; | 1997 |
Temporal profile of total, bound, and free Gc-globulin after acetaminophen overdose.
Topics: Acetaminophen; Actins; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug | 2001 |
Pain medicine. The dangers of acetaminophen.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2001 |
Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2001 |
[Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver].
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Am | 2001 |
Acute acetaminophen toxicity: report of a case.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug | 2001 |
Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Campanulaceae; Chemical a | 2001 |
[Anaphylactoid reaction in relation to the use of N-acetylcysteine the prevention of paracetamol hepatotoxicity].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and | 2001 |
A protective role for cyclooxygenase-2 in drug-induced liver injury in mice.
Topics: Acetaminophen; Animals; Celecoxib; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Cycloox | 2001 |
Use of albumin dialysis in the treatment of hepatic and renal dysfunction due to paracetamol intoxication.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Kidn | 2002 |
Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Drug Resistance; Inflamma | 2002 |
Inhibition of the antibody production by acetaminophen independent of liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antibody Formation; Cell Survival; Chemical and Dr | 2002 |
[Acute kidney failure caused by paracetamol poisoning].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Blood Coagulation Tests; Chemical and Drug Induced Liver | 2001 |
Acetaminophen-induced immunosuppression associated with hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antibody Formation; Chemical and Drug Induced Liver In | 2000 |
Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Aging; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced L | 2002 |
Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrin | 2001 |
Acetaminophen toxicity: suicidal vs. accidental.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2002 |
Acetaminophen hepatotoxicity: the first 35 years.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspa | 2002 |
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2002 |
The effect of alcohol on acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; | 2002 |
Is acetaminophen really safe in alcoholic patients?
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Risk | 2002 |
Alcohol, acetaminophen, and toxic effects on the liver.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Liver; Risk | 2002 |
Acetaminophen poisoning in children: treat early and long enough.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2002 |
Predictors of outcome after acetaminophen poisoning in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; | 2002 |
Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Biotransformation; Chemical and Drug Induc | 2002 |
Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin.
Topics: Acetaminophen; Animals; Biliverdine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Ferri | 2002 |
Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dioscorea; | 2002 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; C | 2002 |
Paracetamol metabolism following overdosage: application of high performance liquid chromatography.
Topics: Acetaminophen; Adult; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, Hig | 1977 |
Letter: cysteamine treatment in paracetamol overdose.
Topics: Acetaminophen; Adult; Alcohol Drinking; Aspartate Aminotransferases; Chemical and Drug Induced Liver | 1975 |
Liver damage after paracetamol overdose. Comparison of liver-function tests, fasting serum bile acids, and liver histology.
Topics: Acetaminophen; Adolescent; Adult; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cyst | 1975 |
Letter: Risk of hepatic coma in paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; Humans; Liver | 1975 |
Editorial: Paracetamol hepatotoxicity.
Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Cystamine; Drug Evaluation; Glutat | 1975 |
Letter: Paracetamol hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Death, Sudden; Humans; Kidney Tubular Necrosi | 1976 |
Letter: Paracetamol hepatoxicity.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver; Necrosis | 1976 |
Letter: Breathing control in liver disease.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; L | 1976 |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1976 |
Oral methionine in the treatment of severe paracetamol (Acetaminophen) overdose.
Topics: Acetaminophen; Administration, Oral; Antidotes; Chemical and Drug Induced Liver Injury; Drug Evaluat | 1976 |
Effect of N-acetylcysteine on hepatic covalent binding of paracetamol (acetaminophen)
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Inactivation, Metabo | 1977 |
Hepatotoxic dose of paracetamol.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans | 1977 |
[Characteristics of hepatocytes containing alpha-fetoprotein in regenerating mouse liver].
Topics: Acetaminophen; Alcohols; alpha-Fetoproteins; Animals; Carbon Tetrachloride Poisoning; Chemical and D | 1977 |
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine | 1977 |
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine | 1977 |
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine | 1977 |
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine | 1977 |
Chronic hepatic inflammation and fibrosis due to low doses of paracetamol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Hip Joint; Humans; Joint Dis | 1978 |
Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteamine; Electron Tra | 1978 |
[Reactive metabolites of xenobiotics : their role in the hepatotoxicity of drugs].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1979 |
Biochemical changes after hepatic injury from toxic doses of acetaminophen or furosemide.
Topics: Acetaminophen; Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 1976 |
Prevention of paracetamol-induced liver damage in mice with glutathione.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gl | 1975 |
Preventing hepatotoxicity in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Chemical and Drug Induced Liver Injury; Diuretics; Glutathi | 1979 |
Acetaminophen: report of an unusual poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Half-Life; Humans; | 1978 |
Acetaminophen overdosage.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Half-Life; Humans; Liver; Male | 1977 |
Acute structural hepatic alteration due to poisons.
Topics: Acetaminophen; Acute Disease; Amanita; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liv | 1977 |
The role of metabolic activation for drug-induced liver injuries.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyld | 1977 |
Clinical and experimental aspects of paracetamol hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Necrosis | 1977 |
Therapeutic aspects of paracetamol overdose including management of acute liver failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Tiopronin | 1977 |
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li | 1977 |
[Therapy of paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Methionin | 1979 |
Comparison of in vivo and in vitro drug metabolism in experimental hepatic injury in the rat.
Topics: Acetaminophen; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon | 1979 |
[Adaptation and toxicity].
Topics: Acetaminophen; Adaptation, Physiological; Antineoplastic Agents; Chemical and Drug Induced Liver Inj | 1979 |
Oxacillin and hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Meprobamate; Oxacillin; P | 1979 |
Inhibition of acetaminophen-induced hepatotoxicity by phenacetin and its alkoxy analogs.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Isocitrate Dehydrogenas | 1979 |
Use of plasma concentration determinations: acetaminophen intoxication.
Topics: Acetaminophen; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Child, Preschool; Humans; T | 1979 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptiv | 1979 |
Dose-dependent biliary and renal excretion of paracetamol in the rat.
Topics: Acetaminophen; Administration, Oral; Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Dru | 1979 |
Studies on the mechanism of paracetamol-induced protection against paracetamol hepatotoxicity.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liv | 1979 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine | 1979 |
Acetaminophen overdose: a growing health care hazard.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Ga | 1979 |
Acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Liver; Methionine | 1979 |
The effect of age on paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Aging; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1979 |
The effect of dichloralphenazone pretreatment on paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Cytochr | 1979 |
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cyst | 1979 |
Protective role of S-adenosyl-l-methionine against acetaminophen induced mortality and hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzymes; Glutathione; L | 1979 |
Paracetamol poisoning. Prevention of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Necrosis | 1979 |
[Hepatic toxicity of paracetamol].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Liver | 1979 |
Acetaminophen assay: the clinical consequences of a colorimetric vs a high-pressure liquid chromatography determination in the assessment of two potentially poisoned patients.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; | 1979 |
The influence of ethanol pretreatment on the effects of nine hepatotoxic agents.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alcoholic Intoxication; Amanitins; Anilin | 1978 |
Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Chemical a | 1978 |
Liver toxicity after acetaminophen ingestion. Inadequacy of the dose estimate as an index of risk.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Half-Life; Humans; | 1977 |
Activation of alpha-methyldopa, paracetamol and furosemide by human liver microsomes.
Topics: Acetaminophen; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sy | 1977 |
[Influence of 2-dimethylaminoethanol on the hepatotoxicity of paracetamol in rats and mice (author's transl)].
Topics: Acetaminophen; Alanine Transaminase; Aniline Compounds; Animals; Aspartate Aminotransferases; Chemic | 1979 |
Acetaminophen overdose.
Topics: Acetaminophen; Adult; Biotransformation; Chemical and Drug Induced Liver Injury; Female; Humans; Pre | 1978 |
Acetaminophen and liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Liver | 1978 |
Late treatment of paracetamol poisoning with mercaptamine.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1978 |
Acetaminophen and the liver.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Male; Necrosi | 1978 |
[Paracetamol poisoning].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; Humans; Liver; Progno | 1978 |
An in vitro model of liver injury using paracetamol treatment of liver slices and prevention of injury by some antioxidants.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dealkylation; Glutathi | 1978 |
Fatal acetaminophen overdosage in a young child.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Humans; Kidney; Liv | 1978 |
Relations between hepatotoxicity and pharmacokinetics of paracetamol in rats and mice.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Indu | 1978 |
[Paracetamol poisoning--liver damage].
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Middle Ag | 1978 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Infectious Mononucleosis; Mal | 1978 |
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cyst | 1978 |
Acetaminophen poisoning: a case report of the use of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Codeine; Female; Human | 1978 |
Acute acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Hu | 1978 |
Liver and kidney damage induced by N-hydroxyparacetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Stability; Glutathione; Hydroxy | 1978 |
Aminopyrine disposition: a sensitive index of acetaminophen-induced hepatocellular damage.
Topics: Acetaminophen; Aminopyrine; Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Glutath | 1978 |
Analgesic hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Salicylates | 1978 |
Drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related | 1978 |
Acetaminophen overdoses at a county hospital: a year's experience.
Topics: Acetaminophen; Acidosis; Adult; Amylases; Chemical and Drug Induced Liver Injury; Female; Hospitals, | 1978 |
Paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; England; Humans; Wales | 1978 |
Repeated self-poisoning with paracetamol.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Male; Suicide, Attempted | 1978 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Female; Humans; Infant; | 1978 |
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Male; Mesocricetus; Meth | 1978 |
Concomitant alcohol and drug abuse enhancing acetaminophen toxicity. Report of a case.
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Alcoholism; Chemical and Drug Induced Liver Injury; Fe | 1978 |
Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Dose-Response Relationship | 1976 |
Genetic aspects of toxicity during development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Acetaminophen; Alleles; Animals; Aryl | 1976 |
Acetaminophen and hepatic necrosis.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Necrosis | 1977 |
Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine.
Topics: Acetaminophen; Amino Acids, Sulfur; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Li | 1977 |
Acetaminophen toxicity.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Liver | 1977 |
Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage.
Topics: Acetaminophen; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Endotoxins; Hepatitis, V | 1977 |
Hepatotoxicity in acetaminophen poisoning.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Suicide, Attempted | 1977 |
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans | 1977 |
[Liver damage after paracetamol].
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans | 1977 |
[Paracetamol --a harmless analgesic?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Liver; Nonprescripti | 1977 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23--1977.
Topics: Acetaminophen; Acute Disease; Adolescent; Arthritis, Juvenile; Aspirin; Brain Death; Brain Edema; Ch | 1977 |
Acetaminophen toxity.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Li | 1977 |
Assessment of acetaminophen toxicity from single plasma values.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Models, Biological; Time Factors | 1977 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Methionine | 1977 |
[We must teach people how to deal with analgesic drugs].
Topics: Acetaminophen; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Kidney; Liver; Salicylate | 1977 |
Early prediction of the outcome of a paracetamol overdose based on an analysis of 163 patients.
Topics: Acetaminophen; Bilirubin; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver Diseases | 1977 |
Acetaminophen and hepatic dysfunction in infectious mononucleosis.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Infectious Mononucleos | 1977 |
Liver function and structure in survivors of acetaminophen poisoning. A follow-up study of serum bile acids and liver histology.
Topics: Acetaminophen; Aspartate Aminotransferases; Bile Acids and Salts; Chemical and Drug Induced Liver In | 1977 |
The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.
Topics: Acetaminophen; Acute Disease; Biliary Tract Diseases; Blood Coagulation Factors; Chemical and Drug I | 1977 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver Diseases | 1977 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytoc | 1977 |
Chronic excessive acetaminophen use and liver damage.
Topics: Acetaminophen; Aged; Alcoholism; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury; F | 1977 |
Chronic liver disease and acetaminophen.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Gluta | 1977 |
Host susceptibility and acetaminophen liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diet; Humans; Rats; Vitamin E | 1977 |
Portal venous infusion of paracetamol and antipyrine in the rat.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Injections, I | 1977 |
Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia.
Topics: Acetaminophen; Acute Disease; Anemia; Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; | 1977 |
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronate | 1976 |
[Letter: Paracetamol--liver toxicity!].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans | 1976 |
[Resistance of regenerating liver to hepatotoxins].
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Live | 1976 |
[Paracetamol poisoning--liver damage. Therapy or prevention?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Glutathione; Humans; Liver | 1976 |
Early unconjugated hyperbilirubinaemia after paracetamol overdosage.
Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Humans; Hyperbili | 1976 |
Fatal massive hepatic necrosis following acetaminophen overdose.
Topics: Acetaminophen; Adult; Autopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney; Kidne | 1976 |
Paracetamol hepatotoxicity and vitamin E.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr | 1976 |
Editorial: Paracetamol and the liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Dis | 1976 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
Progress in hepatology. Metabolic activation of drugs to toxic substances.
Topics: Acetaminophen; Animals; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chemical Pheno | 1975 |
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto | 1975 |
Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enzyme Induct | 1975 |
Acetaminophen poisoning and toxicity.
Topics: Acetaminophen; Agranulocytosis; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Hypoglyc | 1975 |
[Paracetamol poisoning--liver damage].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Half-Life; Humans | 1975 |
Editorial: Paracetamol (acetaminophen) and the liver.
Topics: Acetaminophen; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Humans; Inactivation, Met | 1975 |
Experimental paracetamol-induced hepatic necrosis: a light- and electron-microscope, and histochemical study.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu | 1975 |
Disturbances in glucose metabolism in patients with liver damage due to paracetamol overdose.
Topics: Acetaminophen; Adolescent; Adult; Aspartate Aminotransferases; Blood Glucose; Chemical and Drug Indu | 1975 |
Serum transaminase levels after experimental paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1975 |
A dog model of fulminant hepatic failure produced by paracetamol administration.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 1975 |
Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Follow- | 1975 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1976 |
Serum ferritin levels in acute hepatocellular damage from paracetamol overdosage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Ferritins; Humans; Male | 1976 |
[Problems with analgetics].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Dextropropoxyphene; Dose-Response Relationshi | 1976 |
[Paracetamol poisoning--clinical picture and treatment possibilities].
Topics: Acetaminophen; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Drug | 1976 |
[A case of paracetamol poisoning with reversible liver damage--some reflections].
Topics: Acetaminophen; Adolescent; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; | 1976 |
[Adverse drug effects and the liver].
Topics: Acetaminophen; Adult; Aged; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Ad | 1992 |
Protective activity of silipide on liver damage in rodents.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Pois | 1992 |
[Two cases of severe liver injuries induced by acetaminophen].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Glucagon; Huma | 1992 |
[Protective action of seed oil of Hippophae rhamnoides L. (HR) against experimental liver injury in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Indu | 1992 |
Enhanced tumor necrosis factor alpha in coronavirus but not in paracetamol-induced acute hepatic necrosis in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Coronaviridae | 1992 |
Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Immunoh | 1992 |
31P magnetic resonance spectroscopy detects a functional abnormality in liver metabolism after acetaminophen poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Magnet | 1992 |
[Effect of captopril on glutathione level in the liver and paracetamol-induced liver damage in rats].
Topics: Acetaminophen; Animals; Captopril; Chemical and Drug Induced Liver Injury; Disease Models, Animal; D | 1992 |
Does hypothermia protect against the development of hepatitis in paracetamol overdose?
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoth | 1992 |
[Effects of astragalus (ASI, SK) on experimental liver injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1992 |
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 1992 |
Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans | 1992 |
Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response | 1992 |
Paracetamol overdose in Jerusalem, 1984-89.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; D | 1992 |
Paracetamol overdose in Israel--1992.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Glutathione; H | 1992 |
Prevention of acetaminophen-induced liver damage by Berberis aristata leaves.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Che | 1992 |
Cysteine isopropylester protects against paracetamol-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Chemical | 1992 |
Acetylcysteine and fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Biological Transport; Chemical and Drug Induced Liver Injury; Hemodyn | 1992 |
Recognizing acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Ove | 1992 |
Glutamine preserves liver glutathione after lethal hepatic injury.
Topics: Acetaminophen; Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Glutamine; Glu | 1992 |
Protection against acetaminophen hepatotoxicity by ribose-cysteine (RibCys).
Topics: Acetaminophen; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Cysteine; Dose-Response R | 1992 |
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Chemical and Drug Induced Liver Injury; Hu | 1992 |
Delayed calcium channel blockade with diltiazem reduces paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diltiaz | 1991 |
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical | 1991 |
An improved model of acetaminophen-induced fulminant hepatic failure in dogs.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy; Blood Glucose; Buthionine Sulfoximine; Chemica | 1992 |
Antihepatotoxic properties of picroliv: an active fraction from rhizomes of Picrorhiza kurrooa.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cinnamates; Galactosamine; Glycoside | 1991 |
[The protective effect of (4R)-hexahydro-7, 7-dimethyl-6-oxo-1, 2, 5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on acetaminophen-induced liver injury].
Topics: Acetaminophen; Animals; Azocines; Chemical and Drug Induced Liver Injury; Disulfides; Liver; Liver D | 1991 |
[Paracetamol in therapeutic dosages can cause severe hepatic and renal damage in alcoholics].
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Kidn | 1991 |
Liver transplantation after paracetamol overdose.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Decision Making; Drug Overdose; Female | 1991 |
Postnatal mice have low susceptibility to paracetamol toxicity.
Topics: Acetaminophen; Age Factors; Animals; Animals, Newborn; Benzoquinones; Chemical and Drug Induced Live | 1991 |
Liver transplantation after paracetamol overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Transplantation | 1991 |
Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with a hepatotoxic dose of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransfer | 1991 |
Acetaminophen, isoniazid, and hepatic toxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoniazid | 1991 |
[The Lobac overview: little risk of adverse effects. Effects on skin and liver are the most common and the most severe].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlormezanone; Drug Combinations; Humans; Ris | 1991 |
Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical | 1991 |
Severe thrombocytopenia after paracetamol overdose.
Topics: Acetaminophen; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; | 1990 |
Effect of potassium ethylxanthogenate on the acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1990 |
[Antipyretic analgesics derived from para-aminophenol].
Topics: Acetaminophen; Aminophenols; Chemical and Drug Induced Liver Injury; Kidney; Phenacetin | 1990 |
Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen.
Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Drug Synergism; Glutathi | 1990 |
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Cell Membrane; Cell Nucleus; Chemical a | 1990 |
Prevention of acetaminophen-induced hepatotoxicity by endotoxin in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Es | 1990 |
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Gl | 1990 |
Lovastatin-acetaminophen subchronic toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver | 1990 |
Severe acetaminophen toxicity in a patient receiving isoniazid.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Interact | 1990 |
Electron transport and protection of liver slices in the late stage of paracetamol injury.
Topics: 2,6-Dichloroindophenol; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Tra | 1990 |
Serial prothrombin time as prognostic indicator in paracetamol induced fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1990 |
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Calcium; Cell Nucleus; Cell Survival; Chemical and Dru | 1990 |
Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Li | 1990 |
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Allopurinol; Animals; Chemical and Drug | 1990 |
Effect of ranitidine on acetaminophen-induced hepatotoxicity in dogs.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dogs; Dose-R | 1990 |
Pharmaco-toxicological effects of acetaminophen in rodents. Battery of tests to screen potential analgesic acetaminophen derivatives.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-St | 1990 |
[Acute toxicity of flesh oil of Hippophae rhamnoides L. and its protection against experimental hepatic injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Indu | 1990 |
Hepatic uptake and antihepatotoxic properties of vitamin E and liposomes in the mouse.
Topics: Acetaminophen; Animals; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Drug Carriers; Galac | 1990 |
Protective effects of Garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1990 |
Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Bilirubin; Chemical an | 1990 |
Can acetaminophen excess result in maternal and fetal toxicity?
Topics: Acetaminophen; Adult; Blood Coagulation Disorders; Cerebral Hemorrhage; Chemical and Drug Induced Li | 1990 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
[Paracetamol, a good analgesic? Yes, but ...].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Epilepsy; Humans | 1990 |
Danazol induced pancreatitis and hepatitis.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Danazol; Female; Humans; L | 1990 |
Acetaminophen hepatotoxicity in the alcoholic.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr | 1990 |
Effect of chlordecone and mirex on the acute hepatotoxicity of acetaminophen in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Interactions; Inse | 1987 |
Early inhibition of the Na+/K+-ATPase ion pump during acetaminophen-induced hepatotoxicity in rat.
Topics: 5'-Nucleotidase; Acetaminophen; Alkylation; Animals; Cell Membrane; Chemical and Drug Induced Liver | 1987 |
Effects of glutathione, as the dextran conjugate, on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dextrans; Glutathione; Liver; Male; | 1989 |
Intrahepatic delivery of glutathione by conjugation to dextran.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Chromatography, | 1989 |
Early indicators of prognosis in fulminant hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Halothan | 1989 |
Effects of inhibitors of phospholipase A2, cyclooxygenase and thromboxane synthetase on paracetamol hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Calcium; Chemical and Drug Induced Liver Injury; Cyclo | 1989 |
Hepatotoxicity of paracetamol in combination with interferon and vinblastine.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Int | 1989 |
Hypophosphataemia and phosphaturia in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Evaluation Studies as | 1989 |
Plasma glutathione S-transferase and F protein are more sensitive than alanine aminotransferase as markers of paracetamol (acetaminophen)-induced liver damage.
Topics: Acetaminophen; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Glutathione Tran | 1989 |
The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Fema | 1989 |
Electron transport and protection of liver slices in the late stage of paracetamol injury of the liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; In Vitro Techniq | 1989 |
Hepatoxicity evaluation in rats given a single overdose of Acetaminophen (Paracetamol).
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Liv | 1989 |
Computer-assisted predictive mathematical relationship among plasma acetaminophen concentration and time and hepatotoxicity in man.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Computer- | 1989 |
Effect of hepatic failure toxins on regenerative enzymes in the liver after injury with galactosamine in the rat.
Topics: Acetaminophen; Ammonium Chloride; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disul | 1989 |
Delayed acetaminophen toxicity despite acetylcysteine use.
Topics: Acetaminophen; Acetylcysteine; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Fema | 1989 |
Hepatitis during measles in young adults: possible role of antipyretic drugs.
Topics: Acetaminophen; Adolescent; Adult; Aminopyrine; Chemical and Drug Induced Liver Injury; Dipyrone; Fem | 1989 |
Comparative study on the toxicity of acetaminophen and mercuric chloride in normal and athymic mice and rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Kidney Cortex; Male; Mercuri | 1989 |
Study of glutathione and glutathione related enzymes in acetaminophen-poisoned mice. Prevention by anethole trithione pretreatment.
Topics: Acetaminophen; Alanine Transaminase; Anethole Trithione; Animals; Anisoles; Aspartate Aminotransfera | 1989 |
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Live | 1989 |
Regenerative enzyme activity of the liver after partial hepatectomy or toxic injury depressed by continuous NH4+ infusion.
Topics: Acetaminophen; Ammonia; Ammonium Chloride; Animals; Chemical and Drug Induced Liver Injury; Galactos | 1989 |
Effects of sulfur-amino acid-deficient diets on acetaminophen metabolism and hepatotoxicity in rats.
Topics: Acetaminophen; Amino Acids, Sulfur; Animals; Chemical and Drug Induced Liver Injury; Diet; Drug Syne | 1989 |
[Protective action of kopsinine F against experimental liver injury in mice].
Topics: Acetaminophen; Alkaloids; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I | 1989 |
Mechanism of paracetamol toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Oxidation-Reduction; | 1986 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Protective effects of selenium on acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1988 |
A dog model for acetaminophen-induced fulminant hepatic failure.
Topics: Acetaminophen; Animals; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Disease Mod | 1989 |
Effect of glucose and gluconeogenic substrates on fasting-induced suppression of acetaminophen glucuronidation in the rat.
Topics: Acetaminophen; Alanine; Animals; Biotransformation; Blood Glucose; Chemical and Drug Induced Liver I | 1989 |
Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Growth; Methi | 1989 |
Does hypophosphatemia play a role in acute liver failure?
Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Fructose; Hepatic Enc | 1989 |
Acetaminophen and p-aminophenol nephrotoxicity in aging male Sprague-Dawley and Fischer 344 rats.
Topics: Acetaminophen; Aging; Aminophenols; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Kidn | 1989 |
Paracetamol: a bitter pill.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Failure, Chronic | 1989 |
Nyquil-associated liver injury.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1989 |
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Calcium-Transporting ATPases; Cell Membrane; Chemica | 1985 |
Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemotaxis; Female; Macrophages; Pha | 1986 |
Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemotactic Factors; Chemotaxis; Fem | 1986 |
Strain differences in susceptibility of normal and diabetic rats to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Dis | 1986 |
Fulminant hepatitis. An ultrastructural study.
Topics: Acetaminophen; Adolescent; Adult; Autopsy; Chemical and Drug Induced Liver Injury; Female; Hepatitis | 1986 |
Protection by zinc against acetaminophen induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Gluc | 1986 |
Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.
Topics: Acetaminophen; Alanine; Animals; Anisoles; Aspartate Aminotransferases; Biotransformation; Butylated | 1986 |
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Inju | 1987 |
A histopathological study of analgesic hepatotoxicity in rabbit.
Topics: Acetaminophen; Acute Disease; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Cholangitis; | 1988 |
Acetaminophen hepatotoxicity in rats is attenuated by silybin dihemisuccinate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Liver Disea | 1988 |
Acetaminophen toxicosis: a potential model for acute liver failure in swine.
Topics: Acetaminophen; Acute Disease; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Mo | 1988 |
Acetaminophen hepatotoxicity in aging rats.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver In | 1988 |
[Paracetamol poisoning in a swine model].
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotr | 1988 |
Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Humans; Li | 1988 |
Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Deferoxamine; Drug Syner | 1988 |
Hepatotoxicity after prolonged use of acetaminophen: a case report.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; Middle Aged | 1988 |
Drug induced hepatic damage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Hypersensitivit | 1988 |
Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models.
Topics: Acetaminophen; Acute Disease; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Disease M | 1988 |
Hepatotoxicity of chronic high dose administration of acetaminophen to mice. A critical review and implications for hazard assessment.
Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Mi | 1988 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthi | 1988 |
Mechanism of inhibition of hepatic bioactivation of paracetamol by dimethyl sulfoxide.
Topics: Acetaminophen; Animals; Bile; Biotransformation; Chemical and Drug Induced Liver Injury; Dimethyl Su | 1988 |
A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure.
Topics: Acetaminophen; Acute Disease; Adenosine Triphosphate; Animals; Carbon Tetrachloride Poisoning; Chemi | 1988 |
In vivo studies on toxic effects of concurrent administration of paracetamol and its N-acetyl-DL-methionine ester (SUR 2647 combination).
Topics: Acetaminophen; Alanine Transaminase; Aminolevulinic Acid; Animals; Chemical and Drug Induced Liver I | 1988 |
Clinical features of acetaminophen toxicity.
Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans | 1988 |
Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Hep | 1988 |
Death of a child associated with multiple overdoses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; | 1988 |
Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Ind | 1988 |
Long-term administration of toxic doses of paracetamol (acetaminophen) to rats.
Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Female; Liver; Liver Fu | 1988 |
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits.
Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; | 1988 |
Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.
Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Coma; F | 1988 |
Disulfiram prevents acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; | 1988 |
[Acute paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Prognosis | 1987 |
Severe liver damage caused by therapeutic doses of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Chemical and Dru | 1987 |
Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Chemical and Drug Induced Liver Injury; Liver; Male | 1987 |
[Protection by fructus Schizandrae against acetaminophen hepatotoxicity in mice].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chine | 1987 |
Sulfate conjugation in drug metabolism: role of inorganic sulfate.
Topics: Acetaminophen; Acetylcysteine; Animals; Arylsulfotransferase; Biotransformation; Chemical and Drug I | 1986 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Biotransformation; Chemical and Drug Induced Liver Injury; | 1987 |
Acetaminophen and alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans; Risk | 1987 |
Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Food; Food Deprivation; Liver Diseas | 1987 |
Paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Female; Gastric L | 1987 |
[Severe liver damage following therapeutic dose of paracetamol].
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Drug Syn | 1987 |
[Severe liver damage following suicidal intake of paracetamol].
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Mal | 1987 |
Acute renal failure due to acetaminophen ingestion without concurrent hepatotoxicity.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Female; Huma | 1987 |
The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
Topics: Acetaminophen; Animals; Benzoquinones; Carmustine; Chemical and Drug Induced Liver Injury; Glutathio | 1987 |
Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice.
Topics: Acetaminophen; Animals; Autoradiography; Body Weight; Chemical and Drug Induced Liver Injury; Glutat | 1987 |
[Extracorporeal hemoperfusion in acute fulminant hepatic failure associated with paracetamol poisoning].
Topics: Acetaminophen; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Hemoperfusion; | 1987 |
Prevention of acetaminophen hepatotoxicity by disulfiram.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disulfiram; Female; Liver; Liver Fun | 1987 |
Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney.
Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced | 1987 |
Delayed enhancement of acetaminophen hepatotoxicity by general anesthesia using diethyl ether or halothane.
Topics: Acetaminophen; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Drug Synergi | 1986 |
Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Cirrhosis | 1986 |
Management of acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Chi | 1986 |
Coma and metabolic acidosis early in severe acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Adolescent; Aged; Blood Gas Analysis; Chemical and Drug Ind | 1986 |
Hemorrhagic pancreatitis associated with acetaminophen overdose.
Topics: Abdomen, Acute; Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Hemorrhage; Humans; Ki | 1986 |
Acetaminophen chronic toxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Risk | 1986 |
Murine acetaminophen hepatotoxicity: temporal interanimal variability in plasma glutamic-pyruvic transaminase profiles and relation to in vivo chemical covalent binding.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Ti | 1986 |
Urine discoloration after acetaminophen overdose.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Aminophenols; Chemical and Drug Induced Liver Injury; Chr | 1986 |
Acetaminophen hepatotoxicity in alcoholics.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Male | 1986 |
Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Criceti | 1986 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Humans | 1986 |
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione; | 1986 |
The chronic hepatotoxic, tumor-promoting, and carcinogenic effects of acetaminophen in male B6C3F1 mice.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnit | 1986 |
Dissociation of increased sulfation from sulfate replenishment and hepatoprotection in acetaminophen-poisoned mice by N-acetylcysteine stereoisomers.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Mice, In | 1986 |
Hepatic regenerative enzyme activity after pericentral and periportal lobular toxic injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver Function Tests; Liver Regenera | 1986 |
Effects of O,O,O-tri-n-alkyl phosphorothioates on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Organothiophosphates; Organoth | 1986 |
[Paracetamol poisoning with fatal necrosis of the liver].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Tubular Necrosis, Acut | 1986 |
[Methionine derivatives with liver protecting activity].
Topics: Acetaminophen; Alcoholic Intoxication; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1986 |
Acetaminophen-induced hepatotoxicity: antagonistic action of caffeine in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Binding Sites; Cadmium; C | 1987 |
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
Topics: Acetaminophen; Autopsy; Bacterial Infections; Chemical and Drug Induced Liver Injury; Drug Synergism | 1986 |
Acetaminophen, alcohol, and cytochrome P-450.
Topics: Acetaminophen; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1986 |
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug I | 1986 |
Ferrous ion supported in vivo lipid peroxidation induced by paracetamol--its relation to hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Ferrous Compounds; Glutathione; Iron | 1986 |
Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Clinica | 1985 |
Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Dr | 1985 |
Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Chromatography | 1985 |
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Chemical and Dru | 1985 |
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 1985 |
Enhanced toxicity of acetaminophen in alcoholics: report of three cases.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol | 1985 |
Potentiation of the hepatotoxic effect of acetaminophen by prior administration of salicylate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Glutathione; Liver; | 1985 |
Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Regeneration; Male; Nec | 1985 |
Paracetamol-induced acute renal failure in the absence of severe liver damage.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Female; Huma | 1985 |
Nyquil and acute hepatic necrosis.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1985 |
Effect of malotilate on paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Glutathione; L | 1985 |
Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochro | 1985 |
[Experimental research on the hepatoprotective activity of drug combinations].
Topics: Acetaminophen; Amino Acids; Animals; Catechin; Chemical and Drug Induced Liver Injury; Drug Combinat | 1985 |
Postabsorption antidotal effects of N-acetylcysteine on acetaminophen-induced hepatotoxicity in the mouse.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Bod | 1985 |
Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice.
Topics: Acetaminophen; Alcohol Drinking; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Cytoch | 1985 |
Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Glutathione; Liver; Rats; Ra | 1985 |
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
Topics: Acetaminophen; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disulfides; Hepatectomy; | 1985 |
Iatrogenic drug toxicity.
Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interaction | 1985 |
Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Diagn | 1985 |
Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Cadmium Poisoning; Chemical and Drug Induc | 1985 |
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.
Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1985 |
Acetaminophen: acute overdose toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Pre | 1985 |
Haemodialysis in paracetamol self-poisoning.
Topics: Acetaminophen; Adult; Autoanalysis; Chemical and Drug Induced Liver Injury; Female; Half-Life; Human | 1972 |
Hepatic damage and death from overdose of paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Aspartate Aminotransferases; Bilirubin; Biopsy; Blood Coagulation | 1973 |
Removal of paracetamol by hemoperfusion.
Topics: Acetaminophen; Blood Coagulation Disorders; Blood Platelets; Chemical and Drug Induced Liver Injury; | 1973 |
Letter: Treatment of acute paracetamol hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Circulation; Microscopy | 1973 |
Letter: Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Alprenolol; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationsh | 1973 |
Letter: Drugs that prevent tissue injury.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Evalua | 1973 |
Letter: Paracetamol toxicity and propranolol.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago | 1973 |
Successful treatment of severe paracetamol overdosage with cysteamine.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Blood Cell Count; Blood Urea Nitrogen; Chemical and Dru | 1974 |
Letter: Treatment of paracetamol overdosage.
Topics: Acetaminophen; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Human | 1974 |
Letter: B.A.L. in paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Dimercaprol; Drug Evaluation; Hum | 1974 |
Effects of mepyramine, promethazine, and hydrocortisone on paracetamol-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Ethylenediamines; | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury; | 1968 |
Proceedings: Hepatotoxicity and metabolism of paracetamol in rats and mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography | 1974 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; | 1974 |
Fibrinogen in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Contusions; Endotox | 1974 |
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcin | 1974 |
Abnormal drug metabolism after barbiturate and paracetamol overdose.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin; | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl | 1974 |
Paracetamol overdose: a plan of management.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury; | 1974 |
Coagulation abnormalities in acute liver failure; pathogenetic and therapeutic implications.
Topics: Acetaminophen; Acute Disease; Bilirubin; Biopsy; Blood Coagulation Disorders; Blood Coagulation Test | 1973 |
[Liver damage following paracetamole poisoning].
Topics: Acetaminophen; Acute Kidney Injury; Animals; Autopsy; Blood Sedimentation; Chemical and Drug Induced | 1972 |
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami | 1974 |
Self-poisoning with paracetamol.
Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Dr | 1972 |
Gross paracetamol overdosage with recovery.
Topics: Acetaminophen; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis; Pre | 1973 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, | 1973 |
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; | 1973 |
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
Topics: Acetaminophen; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; Cysteine; Glutathio | 1973 |
Disorderd hemostasis in liver damage from paracetamol overdose.
Topics: Acetaminophen; Adult; Bilirubin; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Chemica | 1973 |
Acetaminophen poisoning.
Topics: Acetaminophen; Adolescent; Catalogs, Drug as Topic; Charcoal; Chemical and Drug Induced Liver Injury | 1973 |
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth | 1973 |
[New forms of toxic hepatitis. II].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Methyldopa; Pemoline | 1973 |
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotr | 1973 |
The effect of phenobarbitone pretreatment on paracetamol toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1973 |
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin | 1974 |
Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.
Topics: Acetaminophen; Animals; Binding Sites; Chemical and Drug Induced Liver Injury; Cricetinae; Glutathio | 1974 |
Activated charcoal for acute acetaminophen intoxication.
Topics: Acetaminophen; Charcoal; Chemical and Drug Induced Liver Injury; Humans | 1972 |
Hepatic damage from overdose of paracetamol.
Topics: Acetaminophen; Animals; Blood; Charcoal; Chemical and Drug Induced Liver Injury; Heparin; Humans; Po | 1972 |
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroence | 1971 |
Acetaminophen-induced hepatic necrosis and renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; H | 1971 |
[Paracetamol].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Necrosis | 1971 |
Acute paracetamol poisoning.
Topics: Acetaminophen; Acidosis; Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and D | 1970 |
Experimental paracetamol-induced hepatic necrosis: a histopathological study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Liver; Liver D | 1971 |
Liver necrosis and myocardiopathy following paracetamol overdosage.
Topics: Acetaminophen; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1968 |
Hepatic and renal damage with paractamol overdosage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Liver; Liver Disease | 1968 |
Paracetamol overdose and liver damage.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Kidney Tubules; Male; Middle A | 1969 |
Acute hepatic necrosis following an overdose of paracetamol.
Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Bilirubin; Blood Glucose; Chemical and Dru | 1969 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis | 1966 |
Acute liver necrosis following overdose of paracetamol.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemia; Male; Ne | 1966 |
Liver damage and impaired glucose tolerance after paracetamol overdosage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Glucose Tolerance Test; Humans; Hyperglycemia | 1966 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Organ Size; Phenacet | 1966 |