Page last updated: 2024-10-22

acetaminophen and Acute Kidney Injury

acetaminophen has been researched along with Acute Kidney Injury in 179 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

ExcerptRelevanceReference
"PACKNOW was an open-label, randomized, controlled trial of acetaminophen (500 mg or 1000 mg every 6 hours for 72 hours) vs no acetaminophen in Malaysian patients aged ≥5 years with knowlesi malaria of any severity."9.51The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial. ( Anstey, NM; Barber, BE; Birrell, GW; Cooper, DJ; Dondorp, AM; Edstein, MD; Grigg, MJ; Koleth, G; Menon, J; Patel, A; Piera, KA; Plewes, K; Rajahram, GS; Tarning, J; Wattanakul, T; Wen Yeo, T; William, T, 2022)
"The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure."7.96Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020)
"The objective of this study was to determine: 1) the incidence and the risk factors of diclofenac/acetaminophen combination as a single agent induced Acute Kidney Injury (AKI) in postoperative pain relief 2) the average cost and length of hospital stay for patients in AKI group and non-AKI group."7.88Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief. ( Banh, HL; Cave, A; Li, YY; Luo, JQ; Wang, Q; Xiao, YW; Xu, P; Zhou, YG; Zhu, Y, 2018)
"Mitochondrial complex I inhibitor rotenone protected kidneys against APAP-induced injury possibly via the inhibition of mitochondrial oxidative stress and inflammation."7.88Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. ( Chen, L; Ge, X; Hua, H; Huang, S; Jia, Z; Wu, M; Yang, G; Zhang, A; Zhang, Y; Zhu, C, 2018)
"Acute kidney injury (AKI) occurs in 2-10% of patients with acetaminophen (APAP) overdose."7.83Incidence and characterization of acute kidney injury after acetaminophen overdose. ( Rice, TW; Stollings, JL; Wheeler, AP, 2016)
"Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages."7.81Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen. ( Aizawa, T; Hirono, K; Ito, E; Ito, T; Joh, K; Tanaka, H; Tsuruga, K; Watanabe, S, 2015)
"Acetaminophen overdose can lead to severe liver and kidney failure; however, the risk of therapeutic doses in healthy individuals causing acute kidney injury (AKI) is less clear."7.80Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases. ( Asakawa, S; Fujigaki, Y; Furunishi, J; Higaki, M; Hoshimoto, K; Inoue, R; Kato, H; Shima, T; Shin, S; Tanemoto, M; Uchida, S; Uozaki, H; Yamaguchi, Y, 2014)
"Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking."7.80Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014)
"A five-fold overdose of acetylcysteine was followed by unexpected hemolysis and acute renal failure."7.77Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. ( Mullins, ME; Vitkovitsky, IV, 2011)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."7.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
"Acetaminophen treatment was significantly associated with a 14%-16% lower risk of severe and any-stage acute kidney injury but similar risks of kidney replacement therapy and in-hospital mortality."5.91Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery. ( Jia, Y; Sessler, DI; Wu, X; Xiong, C; Yan, F; Yuan, S; Zhao, Y, 2023)
"Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models."5.72Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin. ( Abdel Kader, DH; Al-Ani, B; Dallak, M; Dawood, AF; Eid, RA; Haidara, MA; Kamar, SS; Shams Eldeen, AM, 2022)
"PACKNOW was an open-label, randomized, controlled trial of acetaminophen (500 mg or 1000 mg every 6 hours for 72 hours) vs no acetaminophen in Malaysian patients aged ≥5 years with knowlesi malaria of any severity."5.51The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial. ( Anstey, NM; Barber, BE; Birrell, GW; Cooper, DJ; Dondorp, AM; Edstein, MD; Grigg, MJ; Koleth, G; Menon, J; Patel, A; Piera, KA; Plewes, K; Rajahram, GS; Tarning, J; Wattanakul, T; Wen Yeo, T; William, T, 2022)
"Acetaminophen (APAP) has been shown to inhibit lipid peroxidation and, thus, may be renal protective in patients with sepsis."5.48Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis. ( Aljuhani, O; Bakhsh, H; Erstad, BL; Patanwala, AE, 2018)
"Acetaminophen doses were 60 (95% CI, 40-87) mg/kg in those with AKI vs 70 (95% CI, 45-94) mg/kg in those without AKI (P = ."5.48Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery. ( Choi, L; Darghosian, L; Hill, KD; Jooste, EH; Kannankeril, PJ; Roden, DM; Shi, Y; Smith, AH; Van Driest, SL; Ware, LB, 2018)
" Limitations include retrospective review, selection bias, and absence of data on detail medications used, laboratory investigations and dosage of APAP intoxication."5.42Risk of Acute Kidney Injury and Long-Term Outcome in Patients With Acetaminophen Intoxication: A Nationwide Population-Based Retrospective Cohort Study. ( Chang, PY; Chen, JH; Chen, YG; Dai, MS; Huang, TC; Kao, CH; Lin, CL; Wu, YY, 2015)
" Regular acetaminophen use should be reassessed in patients with uncontrolled hypertension."5.41Literature review: are NSAIDs harmful and is acetaminophen well tolerated? ( Abbasi, M; Teakell, J, 2023)
"Rhabdomyolysis is an important cause of acute renal failure (ARF) and renal vasoconstriction is the main mechanism in the pathogenesis of ARF."5.38Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. ( Cil, O; Ertunc, M; Gucer, KS; Iskit, AB; Onur, R; Ozaltin, F, 2012)
"In many parts of Europe, nephropathia epidemica (NE) is an endemic zoonosis."5.38Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica. ( Leicht-Biener, U; Mucsi, I; Seitz, K; Wagner, R, 2012)
"Vomiting was present in 65."5.36Assessing the impact of vomiting episodes on outcome after acetaminophen poisoning. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010)
"We identified 109 cases of acute renal failure among children."5.30Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team. ( Barr, DB; Barr, JR; Denerville, K; Espindola, J; Hecdivert, C; Hospedales, CJ; Lewis, MJ; Louis, M; Needham, LL; O'Brien, KL; Philen, RM; Placide, MF; Schwartz, B; Selanikio, JD; St Victor, S, 1998)
" The development of type B lactic acidosis with hypoglycemia might have been caused by a deficit in gluconeogenesis secondary to severe hepatic failure and/or a toxic metabolite of acetaminophen."5.27Anion gap acidosis with hypoglycemia in acetaminophen toxicity. ( Schnurr, LP; Zabrodski, RM, 1984)
"Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long record of use in acute and chronic pain."4.98Long-term adverse effects of paracetamol - a review. ( Dear, JW; MacIntyre, IM; McCrae, JC; Morrison, EE; Webb, DJ, 2018)
"Acetaminophen is the most commonly reported drug overdose in the United States."4.79Acute renal failure due to acetaminophen ingestion: a case report and review of the literature. ( Blakely, P; McDonald, BR, 1995)
"The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure."3.96Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020)
"The objective of this study was to determine: 1) the incidence and the risk factors of diclofenac/acetaminophen combination as a single agent induced Acute Kidney Injury (AKI) in postoperative pain relief 2) the average cost and length of hospital stay for patients in AKI group and non-AKI group."3.88Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief. ( Banh, HL; Cave, A; Li, YY; Luo, JQ; Wang, Q; Xiao, YW; Xu, P; Zhou, YG; Zhu, Y, 2018)
"Mitochondrial complex I inhibitor rotenone protected kidneys against APAP-induced injury possibly via the inhibition of mitochondrial oxidative stress and inflammation."3.88Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. ( Chen, L; Ge, X; Hua, H; Huang, S; Jia, Z; Wu, M; Yang, G; Zhang, A; Zhang, Y; Zhu, C, 2018)
"To evaluate whether the urinary HSP72 levels (uHSP72) are a useful biomarker for early diagnosis of acute kidney injury (AKI) induced by two widely used drugs: cisplatin and acetaminophen."3.85HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity. ( Aguilar-Carrasco, JC; Barrera-Chimal, J; Bobadilla, NA; Cruz, C; González-Bobadilla, Y; Lima-Posada, I; Pérez-Villalva, R; Ramírez, V; Trumper, L; Uribe, N, 2017)
"Acute kidney injury (AKI) occurs in 2-10% of patients with acetaminophen (APAP) overdose."3.83Incidence and characterization of acute kidney injury after acetaminophen overdose. ( Rice, TW; Stollings, JL; Wheeler, AP, 2016)
"Acetaminophen-induced fulminant hepatic failure is associated with acute kidney injury, metabolic acidosis, and fluid and electrolyte imbalances, requiring treatment with renal replacement therapies."3.81The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies. ( Hernandez, SH; Hoffman, RS; Howland, M; Schiano, TD, 2015)
"Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages."3.81Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen. ( Aizawa, T; Hirono, K; Ito, E; Ito, T; Joh, K; Tanaka, H; Tsuruga, K; Watanabe, S, 2015)
" Patients were classified by the Acute Kidney Injury Network criteria, as well as for etiology of liver failure (acetaminophen-based, ischemic, and all others)."3.81Risk factors and outcomes of acute kidney injury in patients with acute liver failure. ( Hynan, LS; Larson, AM; Lee, WM; Sanders, CM; Seremba, E; Tujios, SR; Vazquez, MA, 2015)
"Acetaminophen overdose can lead to severe liver and kidney failure; however, the risk of therapeutic doses in healthy individuals causing acute kidney injury (AKI) is less clear."3.80Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases. ( Asakawa, S; Fujigaki, Y; Furunishi, J; Higaki, M; Hoshimoto, K; Inoue, R; Kato, H; Shima, T; Shin, S; Tanemoto, M; Uchida, S; Uozaki, H; Yamaguchi, Y, 2014)
"Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking."3.80Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014)
"A five-fold overdose of acetylcysteine was followed by unexpected hemolysis and acute renal failure."3.77Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. ( Mullins, ME; Vitkovitsky, IV, 2011)
"We report a case of neonatal transient renal failure after maternal ingestion of diclofenac, paracetamol, and nimesulide during pregnancy."3.72In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. ( Benini, D; Cuzzolin, L; Fanos, V; Tatò, L, 2004)
"We describe a patient with acute liver and renal failure secondary to acetaminophen and chronic alcohol abuse who was treated aggressively with oral acetylcysteine, continuous renal replacement therapy, glucose and branched-chain amino acid intravenous feeding and ventilatory support."3.71Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile? ( Agarwal, R; Farber, MO, 2002)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."3.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
"Analgesic nephropathy is part of a wider clinical syndrome associated with the abuse of APC compounds, that is, a minimum total intake of 2 kg of aspirin or phenacetin."3.65Analgesic nephropathy. ( Nanra, RS, 1976)
"Paracetamol is widely available and has an excellent safety profile; if a renoprotective effect is demonstrated, this trial will support the administration of regularly dosed paracetamol to all patients with knowlesi malaria."2.87The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial. ( Anstey, NM; Barber, BE; Chatfield, MD; Cooper, DJ; Dondorp, AM; Grigg, MJ; Piera, KA; Plewes, K; Rajahram, GS; William, T; Yeo, TW, 2018)
"Sepsis is a heterogeneous clinical syndrome that is complicated commonly by acute kidney injury (sepsis-AKI)."2.66The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. ( Kerchberger, VE; Ware, LB, 2020)
"Curcumin has useful biological features that include antioxidant, anti-inflammatory, and anticancer properties."2.61Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies. ( Barreto, GE; Beiraghdar, F; Motaharinia, J; Panahi, Y; Sahebkar, A, 2019)
"The significance of acute renal insufficiency has grown in the past decade."2.44[Renal insufficiency caused by medicines, diagnostic processes, toxins]. ( Szegedi, J, 2007)
" In contrast, non-NSAID analgesics, such as paracetamol or tramadol, have essentially no renal or related cardiovascular side effects when used at recommended dosing schedules."2.41Renal and related cardiovascular effects of conventional and COX-2-specific NSAIDs and non-NSAID analgesics. ( Whelton, A, 2000)
"Fluid and electrolyte disturbances, acute renal failure, and acute interstitial nephritis also occur predominantly with NSAIDs."2.39Renal effects of over-the-counter analgesics. ( Whelton, A, 1995)
"Acetaminophen treatment was significantly associated with a 14%-16% lower risk of severe and any-stage acute kidney injury but similar risks of kidney replacement therapy and in-hospital mortality."1.91Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery. ( Jia, Y; Sessler, DI; Wu, X; Xiong, C; Yan, F; Yuan, S; Zhao, Y, 2023)
"Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models."1.72Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin. ( Abdel Kader, DH; Al-Ani, B; Dallak, M; Dawood, AF; Eid, RA; Haidara, MA; Kamar, SS; Shams Eldeen, AM, 2022)
" Variations were observed in the dosing regimen of acetaminophen across the studies."1.62Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. ( Al Ansari, E; Al Jufairi, M; Al Madhoob, A; Al Marzooq, R; Hasan, SJR; Hubail, Z; Sridharan, K, 2021)
"We analyzed postoperative pain intensity, the incidence rate of acute kidney injury, drug-induced liver injury, and rate of elevation in serum creatinine after open radical prostatectomy."1.62Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis. ( Hamada, S; Hamada, Y; Hara, K; Kadowaki, D; Miyamura, S; Nishimura, F; Nojima, M; Oniki, K; Saruwatari, J; Ushijima, T, 2021)
"Acetaminophen (APAP) has been shown to inhibit lipid peroxidation and, thus, may be renal protective in patients with sepsis."1.48Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis. ( Aljuhani, O; Bakhsh, H; Erstad, BL; Patanwala, AE, 2018)
"Acetaminophen doses were 60 (95% CI, 40-87) mg/kg in those with AKI vs 70 (95% CI, 45-94) mg/kg in those without AKI (P = ."1.48Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery. ( Choi, L; Darghosian, L; Hill, KD; Jooste, EH; Kannankeril, PJ; Roden, DM; Shi, Y; Smith, AH; Van Driest, SL; Ware, LB, 2018)
" We found a change in cell viability after 24h incubation with all tested toxic compounds."1.46Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells. ( Čapek, J; Flídr, P; Hauschke, M; Libra, A; Roušar, T; Roušarová, E, 2017)
" Our observation suggested that silymarin ameliorated the toxic effects of APAP-induced hepatotoxicity and nephrotoxicity in mice."1.43Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. ( Baycu, C; Bektur, NE; Sahin, E; Unver, G, 2016)
" Limitations include retrospective review, selection bias, and absence of data on detail medications used, laboratory investigations and dosage of APAP intoxication."1.42Risk of Acute Kidney Injury and Long-Term Outcome in Patients With Acetaminophen Intoxication: A Nationwide Population-Based Retrospective Cohort Study. ( Chang, PY; Chen, JH; Chen, YG; Dai, MS; Huang, TC; Kao, CH; Lin, CL; Wu, YY, 2015)
"Acetaminophen (APAP) is an analgesic and antipyretic agent."1.39The effects of N-acetylcysteine and ozone therapy on oxidative stress and inflammation in acetaminophen-induced nephrotoxicity model. ( Agilli, M; Alp, BF; Aydin, FN; Aydin, I; Cayci, T; Macit, E; Ozcan, A; Ozkan, E; Oztosun, M; Taslipinar, MY; Toygar, M; Ucar, F, 2013)
"Acetaminophen or paracetamol, a commonly used over-the-counter analgesic, is known to elicit severe adverse reactions when taken in overdose, chronically at therapeutic dosage or, sporadically, following single assumptions of a therapeutic dose."1.39Possible fatal acetaminophen intoxication with atypical clinical presentation. ( Carbone, A; Chiarotti, M; d'Aloja, E; De-Giorgio, F; Lodise, M; Valerio, L, 2013)
"In many parts of Europe, nephropathia epidemica (NE) is an endemic zoonosis."1.38Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica. ( Leicht-Biener, U; Mucsi, I; Seitz, K; Wagner, R, 2012)
"Rhabdomyolysis is an important cause of acute renal failure (ARF) and renal vasoconstriction is the main mechanism in the pathogenesis of ARF."1.38Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. ( Cil, O; Ertunc, M; Gucer, KS; Iskit, AB; Onur, R; Ozaltin, F, 2012)
"Acute renal failure is a recognized manifestation of paracetamol toxicity, but comparatively little data is available concerning its onset and duration."1.36Delayed onset of acute renal failure after significant paracetamol overdose: A case series. ( Jamie, H; Leggett, GE; Waring, WS, 2010)
"Vomiting was present in 65."1.36Assessing the impact of vomiting episodes on outcome after acetaminophen poisoning. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010)
"Acute renal failure is commonly seen in adults after treatment with analgesic agents."1.35Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs. ( Baskin, E; Bayrakci, US; Cengiz, N; Erçoban, HS; Melek, E; Onay, OS, 2009)
" Appropriate dosing and managing of these drugs do not likely lead to organ toxicity."1.35Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report. ( Angeli, S; Brugnara, M; Cuzzolin, L; Zaffanello, M, 2009)
"However, acute renal failure, although less frequent, can lead to serious metabolic complications and require hemodialysis."1.35[Acute renal failure after acetaminophen poisoning: report of three cases]. ( Allaouchiche, B; Baillon, JJ; Ber, CE; Christin, F; Hayi-Slayman, D; Hengy, B; Page, M; Rimmelé, T, 2009)
"The patient developed acute renal failure, and also had fever and unilateral ear inflammation."1.35Acute renal failure following detergent ingestion. ( Lim, YC, 2009)
" Physicians should be aware of potential hepatotoxicity and nephrotoxicity of acetaminophen, even if given at therapeutic dosage in acute febrile illness."1.34Therapeutic dose of acetaminophen with fatal hepatic necrosis and acute renal failure. ( Lohachit, P; Ruamvang, T; Satirapoj, B, 2007)
"Two patients with acute renal injury died after admission."1.33Acute renal dysfunction in acetaminophen poisoning. ( Caraccio, T; Feinfeld, DA; McGuigan, M; Mour, G, 2005)
"It is concluded that acute renal failure during paracetamol poisoning may not necessarily be followed by an evident hepatic failure."1.32[Acute renal failure after paracetamol (Acetaminophen) poisoning--report of two cases]. ( Bober, J; Ciechanowski, K; Domański, L; Kedzierska, K; Kwiatkowska, E; Myślak, M; Rózański, J, 2003)
" Increased caution and awareness of the toxic effects of acetaminophen are needed, and it should be dispensed with appropriate package-label warnings."1.31[Acetaminophen toxicity in children as a "therapeutic misadventure"]. ( Granot, E; Ohali, M; Shahroor, S; Shvil, Y, 2000)
"We identified 109 cases of acute renal failure among children."1.30Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team. ( Barr, DB; Barr, JR; Denerville, K; Espindola, J; Hecdivert, C; Hospedales, CJ; Lewis, MJ; Louis, M; Needham, LL; O'Brien, KL; Philen, RM; Placide, MF; Schwartz, B; Selanikio, JD; St Victor, S, 1998)
" The relative bioavailability of cyclosporin in ARF and control rats was 0."1.30Influence of glycerol-induced acute renal failure on the pharmacokinetics of cyclosporin in rats. ( Hoshino, N; Minouchi, T; Ohmae, T; Shibata, N; Yamaji, A, 1999)
"Diethylene glycol was identified in 19 bottles of paracetamol, from 7 of 28 brands tested."1.29Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic. ( Bennish, ML; Donovan, JJ; Hanif, M; Mobarak, MR; Rahman, D; Ronan, A, 1995)
"Eighteen patients in hepatic coma grade III-IV were entered in the study and were divided into two groups in accordance with their renal function (serum creatinine above/below 180 mumol/l)."1.28Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma. ( Dalhoff, K; Hansen, PB; Joffe, P; Olesen, B, 1991)
"The effects of oral dosing with paracetamol (40 mg/kg/day for 3 days) on serum thromboxane B2 (TXB2), glomerular filtration rate (GFR), sodium homeostasis, urinary excretion of prostaglandin E2 (PGE2) and on some other renal function parameters were investigated in 10 healthy young controls aged 23-26 years, 9 healthy elderly persons with normal renal function aged 66-78 years and 9 patients with chronic stable impaired renal function."1.28Acute effects of paracetamol on prostaglandin synthesis and renal function in normal man and in patients with renal failure. ( Berg, KJ; Djøseland, O; Gjellan, A; Hundal, O; Knudsen, ER; Rugstad, HE; Rønneberg, E, 1990)
" The development of type B lactic acidosis with hypoglycemia might have been caused by a deficit in gluconeogenesis secondary to severe hepatic failure and/or a toxic metabolite of acetaminophen."1.27Anion gap acidosis with hypoglycemia in acetaminophen toxicity. ( Schnurr, LP; Zabrodski, RM, 1984)
"In the management of acute renal failure, usually in connection with multiple organic disorders, a nonschematic, individually adapted therapy is indicated."1.27Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis. ( Forycki, Z; Ibe, K; Martens, F; Thalhofer, S, 1985)
"We report two cases of acute renal failure following paracetamol (acetaminophen) poisoning."1.27Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma. ( Davenport, A; Finn, R, 1988)
"Seven patients with acute renal failure after ingestion of analgesic drug combinations including paracetamol were seen."1.27Acute renal failure after analgesic drugs including paracetamol (acetaminophen). ( Aurell, M; Björck, S; Svalander, CT, 1988)
"A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented."1.27Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure. ( Fassett, R; Kritharides, L; Singh, B, 1988)
"Reversible acute renal failure of unknown cause occurred in two men after taking paracetamol in therapeutic doses."1.26Acute tubular necrosis, caused by therapeutic doses of paracetamol? ( Caldwell, J; Gabriel, R; Hartley, RB, 1982)
"It is concluded that acute renal failure without prior hepatic failure may occur after acetaminophen overdose."1.26Acute renal failure after acetaminophen overdose: report of two cases. ( Jeffery, WH; Lafferty, WE, 1981)
"In 2 who developed acute renal failure without porto-systemic encephalopathy, plasma renin activity was noted to rise before serum creatinine and to return to initial levels after 3 or 4 days while renal failure persisted."1.26Plasma renin activity during the development of paracetamol (acetaminophen) induced acute renal failure in man. ( James, OF; Morley, AR; Roberts, SH; Robson, V; Wilkinson, R, 1979)
"Acetaminophen is a safe drug when used properly, but overdosage can cause severe toxicity."1.26Acetaminophen poisoning. ( Calvert, LJ; Linder, CW, 1978)
"Phenacetin pretreatment (597 mg/kg) was less effective, while paracetamol (503 mg/kg) was without effect in this regard."1.26Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol. ( Arnold, L; Collins, C; Starmer, GA, 1976)
"Except in patients with acute renal failure, the urinary excretion rate constants were similar to those observed in patients without liver damage."1.25The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. ( Prescott, LF; Wright, N, 1973)

Research

Studies (179)

TimeframeStudies, this research(%)All Research%
pre-199051 (28.49)18.7374
1990's33 (18.44)18.2507
2000's25 (13.97)29.6817
2010's50 (27.93)24.3611
2020's20 (11.17)2.80

Authors

AuthorsStudies
Nishimura, F1
Ushijima, T1
Nojima, M1
Hamada, S1
Hara, K1
Hamada, Y1
Kadowaki, D1
Miyamura, S1
Oniki, K1
Saruwatari, J1
Cooper, DJ2
Grigg, MJ2
Plewes, K4
Rajahram, GS2
Piera, KA3
William, T2
Menon, J1
Koleth, G1
Edstein, MD1
Birrell, GW1
Wattanakul, T2
Tarning, J2
Patel, A1
Wen Yeo, T1
Dondorp, AM4
Anstey, NM3
Barber, BE2
Williams, M1
Coulson, J1
Xiong, C1
Jia, Y1
Wu, X1
Zhao, Y1
Yuan, S1
Yan, F1
Sessler, DI1
Strehle, EM1
Haar, I1
Abbasi, M1
Teakell, J1
Paasi, G1
Okalebo, CB1
Ongodia, P1
Namayanja, C1
Eregu, EEI1
Abongo, G1
Olupot, M1
Amorut, D1
Muhindo, R1
Okiror, W1
Ndila, C1
Olupot-Olupot, P1
Sümer, E1
Senturk, GE1
Demirel, ÖU1
Yesilada, E1
Dallak, M1
Dawood, AF1
Haidara, MA1
Abdel Kader, DH1
Eid, RA1
Kamar, SS1
Shams Eldeen, AM1
Al-Ani, B1
Kerchberger, VE1
Ware, LB2
Shen, Y1
Jin, X1
Chen, W1
Gao, C1
Bian, Q1
Fan, J1
Luan, J1
Cao, Z1
Guo, Z1
Gu, Y1
Liu, H2
Ju, D1
Mei, X1
Weinstein, RB1
Ryan, PB1
Berlin, JA1
Schuemie, MJ1
Swerdel, J1
Fife, D1
Akgun, E1
Boyacioglu, M1
Kum, S1
Mitsuboshi, S1
Niimura, T1
Zamami, Y1
Akakpo, JY1
Ramachandran, A1
Orhan, H1
Curry, SC1
Rumack, BH1
Jaeschke, H1
Desgrouas, M1
Boulain, T1
Zand Irani, A1
Borchert, G1
Craven, B1
Gibbons, H1
Sridharan, K1
Al Jufairi, M1
Al Ansari, E1
Al Marzooq, R1
Hubail, Z1
Hasan, SJR1
Al Madhoob, A1
Pai, S1
Njoku, DB1
Geoffroy, S1
Fremery, A1
Lambert, Y1
Marty, C1
Elenga, N1
Pérez-Villalva, R1
Barrera-Chimal, J1
Aguilar-Carrasco, JC1
Lima-Posada, I1
Cruz, C1
Ramírez, V1
González-Bobadilla, Y1
Uribe, N1
Trumper, L1
Bobadilla, NA1
Abdel-Hafez, SMN1
Rifaai, RA1
Abd Elzaher, WY1
Patanwala, AE1
Aljuhani, O1
Bakhsh, H1
Erstad, BL1
Gorgulho, R1
Jacinto, R1
Lopes, SS1
Pereira, SA1
Tranfield, EM1
Martins, GG1
Gualda, EJ1
Derks, RJE1
Correia, AC1
Steenvoorden, E1
Pintado, P1
Mayboroda, OA1
Monteiro, EC1
Morello, J1
Turner, GDH2
Zhu, Y1
Xu, P1
Wang, Q1
Luo, JQ1
Xiao, YW1
Li, YY1
Zhou, YG1
Cave, A1
Banh, HL1
Kingston, HWF1
Ghose, A1
Hassan, MMU1
Haider, MS1
Dutta, PK1
Islam, MA1
Alam, S1
Jahangir, SM1
Zahed, ASM1
Sattar, MA1
Chowdhury, MAH1
Herdman, MT1
Leopold, SJ1
Ishioka, H1
Charunwatthana, P1
Silamut, K1
Yeo, TW2
Lee, SJ1
Mukaka, M1
Maude, RJ1
Faiz, MA1
Oates, JA1
White, NJ1
Day, NPJ1
Hossain, MA1
Roberts Ii, LJ1
Chatfield, MD1
Van Driest, SL1
Jooste, EH1
Shi, Y1
Choi, L1
Darghosian, L1
Hill, KD1
Smith, AH1
Kannankeril, PJ1
Roden, DM1
McCrae, JC1
Morrison, EE1
MacIntyre, IM1
Dear, JW2
Webb, DJ2
Hua, H1
Ge, X1
Wu, M1
Zhu, C1
Chen, L1
Yang, G1
Zhang, Y1
Huang, S1
Zhang, A1
Jia, Z1
Karaali, HF1
Fahmi, RR1
Borjac, JM1
Hussain, Z1
Khan, JA1
Arshad, A1
Asif, P1
Rashid, H1
Arshad, MI1
Ozatik, FY1
Teksen, Y1
Kadioglu, E1
Ozatik, O1
Bayat, Z1
Lei, C1
Wang, H1
Liu, C1
Andersen, PE1
Svart, M1
Motaharinia, J1
Panahi, Y1
Barreto, GE1
Beiraghdar, F1
Sahebkar, A1
Ucar, F2
Taslipinar, MY2
Alp, BF2
Aydin, I2
Aydin, FN2
Agilli, M2
Toygar, M2
Ozkan, E2
Macit, E1
Oztosun, M1
Cayci, T2
Ozcan, A1
Cermik, H1
Altayli, E1
Le Vaillant, J1
Pellerin, L1
Brouard, J1
Eckart, P1
Amathieu, R1
Levesque, E1
Merle, JC1
Chemit, M1
Costentin, C1
Compagnon, P1
Dhonneur, G1
De-Giorgio, F1
Lodise, M1
Chiarotti, M1
d'Aloja, E1
Carbone, A1
Valerio, L1
Abraham, P1
Bektur, NE1
Sahin, E1
Baycu, C1
Unver, G1
Aly, HF1
Rizk, MZ1
Abo-Elmatty, DM1
Desoky, MM1
Ibrahim, NA1
Younis, EA1
Yue, Z1
Jiang, P1
Sun, H1
Wu, J1
Simpson, SA1
Zaccagni, H1
Bichell, DP1
Christian, KG1
Mettler, BA1
Donahue, BS1
Roberts, LJ1
Pretorius, M1
Tujios, SR1
Hynan, LS1
Vazquez, MA1
Larson, AM1
Seremba, E1
Sanders, CM1
Lee, WM1
Kato, H1
Fujigaki, Y1
Inoue, R1
Asakawa, S1
Shin, S1
Shima, T1
Furunishi, J1
Higaki, M1
Tanemoto, M1
Yamaguchi, Y1
Hoshimoto, K1
Uozaki, H1
Uchida, S1
Ito, T1
Watanabe, S1
Tsuruga, K1
Aizawa, T1
Hirono, K1
Ito, E1
Joh, K1
Tanaka, H1
Murad, HA1
Habib, H1
Kamel, Y1
Alsayed, S1
Shakweer, M1
Elshal, M1
Martín, B1
Jiménez-Hernández, M1
Prado, V1
Nogué, S1
Hernandez, SH1
Howland, M1
Schiano, TD1
Hoffman, RS1
Vliegenthart, AD1
Shaffer, JM1
Clarke, JI1
Peeters, LE1
Caporali, A1
Bateman, DN1
Wood, DM1
Dargan, PI1
Craig, DG1
Moore, JK1
Thompson, AI1
Henderson, NC1
Sharkey, J1
Antoine, DJ2
Park, BK1
Bailey, MA1
Lader, E1
Simpson, KJ1
Chen, YG1
Lin, CL1
Dai, MS1
Chang, PY1
Chen, JH1
Huang, TC1
Wu, YY1
Kao, CH1
Pavkovic, M1
Robinson-Cohen, C1
Chua, AS1
Nicoara, O1
Cárdenas-González, M1
Bijol, V1
Ramachandran, K1
Hampson, L1
Pirmohamed, M1
Frendl, G1
Himmelfarb, J1
Waikar, SS1
Vaidya, VS1
Stollings, JL1
Wheeler, AP1
Rice, TW1
Çelikmen, MF1
Sarıkaya, S1
Özüçelik, DN1
Sever, MŞ1
Açıksarı, K1
Çelikmen, DM1
Yazıcıoğlu, M1
Kandemir, A1
Doğan, H1
Ayvacı, BM1
Özaşır Abuşka, D1
Sadıllıoğlu, S1
Lipworth, L1
Abdel-Kader, K1
Morse, J1
Stewart, TG1
Kabagambe, EK1
Parr, SK1
Birdwell, KA1
Matheny, ME1
Hung, AM1
Blot, WJ1
Ikizler, TA1
Siew, ED1
Hauschke, M1
Roušarová, E1
Flídr, P1
Čapek, J1
Libra, A1
Roušar, T1
Asao, K1
Gonzales, R1
Isaac, P1
Sachdeva, B1
Abreo, K1
Zaffanello, M1
Brugnara, M1
Angeli, S1
Cuzzolin, L2
Onay, OS1
Erçoban, HS1
Bayrakci, US1
Melek, E1
Cengiz, N1
Baskin, E1
Hengy, B1
Hayi-Slayman, D1
Page, M1
Christin, F1
Baillon, JJ1
Ber, CE1
Allaouchiche, B1
Rimmelé, T1
Lim, YC1
Waring, WS1
Jamie, H1
Leggett, GE1
Zyoud, SH1
Awang, R1
Sulaiman, SA1
Al-Jabi, SW1
Kandiş, H1
Erkan, ME1
Yildirim, U1
Güneş, H1
Erbaş, M1
Yildirim, HA1
Gezer, S1
Kara, IH1
Hanly, LN1
Chen, N1
Aleksa, K1
Cutler, M1
Bajcetic, M1
Palassery, R1
Regueira, O1
Turner, C1
Baw, B1
Malkin, B1
Freeman, D1
Rieder, MJ1
Vasylyeva, TL1
Koren, G1
O'Riordan, A1
Brummell, Z1
Sizer, E1
Auzinger, G1
Heaton, N1
O'Grady, JG2
Bernal, W1
Hendry, BM1
Wendon, JA1
Lines, SW1
Wood, A1
Bellamy, MC1
Lewington, AJ1
Mullins, ME1
Vitkovitsky, IV1
Wagner, R1
Leicht-Biener, U1
Mucsi, I1
Seitz, K1
Cil, O1
Ertunc, M1
Gucer, KS1
Ozaltin, F1
Iskit, AB1
Onur, R1
Abdul Hamid, Z1
Budin, SB1
Wen Jie, N1
Hamid, A1
Husain, K1
Mohamed, J1
Mietka-Ciszowska, A1
Stojakowska, M1
Groszek, B1
Ortiz, A1
Marrón, B1
Justo, P1
Sanz, A1
Martínez, JG1
Saus, C1
Morey, A1
Alarcón, A1
Garcés Redolat, E1
Parra Hernández, A1
Munné Mas, P1
Burillo-Putze, G1
Benini, D1
Fanos, V1
Tatò, L1
Kedzierska, K1
Myślak, M1
Kwiatkowska, E1
Bober, J1
Rózański, J1
Domański, L1
Ciechanowski, K1
Mour, G1
Feinfeld, DA1
Caraccio, T1
McGuigan, M1
Rüster, M1
Kiehntopf, M1
Gröne, HJ1
Wolf, G1
Peter, JV1
Rogers, N1
Murty, S1
Gerace, R1
Mackay, R1
Peake, SL1
Ozçakar, ZB1
Yüksel, S1
Ensari, A1
Ekim, M1
Yalçinkaya, F1
Hari, P1
Jain, Y1
Kabra, SK1
Szegedi, J1
Lubel, JS1
Angus, PW1
Gow, PJ1
Satirapoj, B1
Lohachit, P1
Ruamvang, T1
Curry, RW1
Robinson, JD1
Sughrue, MJ1
Zabrodski, RM1
Schnurr, LP1
Baumgarten, R1
Schneider, W1
Roschlau, G1
Fengler, JD1
Markus, R1
Binus, R1
Stolt, CM1
Johnsen, SA1
Cobden, I1
Record, CO1
Ward, MK1
Kerr, DN1
Prescott, LF4
Proudfoot, AT3
Cregeen, RJ1
Gabriel, R2
Harris, AL1
Stegeman-Castelen, G1
van Hattum, J1
Koomans, HA1
de Vries, J1
van Heijst, AN1
Savides, MC1
Oehme, FW1
Bailey, DN1
Caldwell, J1
Hartley, RB1
Jeffery, WH1
Lafferty, WE1
Johnson, MW1
Friedman, PA1
Mitch, WE1
Gerber, MA1
Kaufmann, H1
Klion, F1
Alpert, LI1
Kleinman, JG1
Breitenfield, RV1
Roth, DA1
Blakely, P1
McDonald, BR1
Hanif, M1
Mobarak, MR1
Ronan, A1
Rahman, D1
Donovan, JJ1
Bennish, ML1
Katzir, Z1
Baruch, O1
Hochman, B1
Biro, A1
Smetana, S1
Whelton, A2
Baudouin, SV1
Howdle, P1
Webster, NR1
Drenth, JP1
Frenken, LA1
Wuis, EW1
Van der Meer, JW1
Douidar, SM1
al-Khalil, I1
Habersang, RW1
Pedersen, CM1
Rasmussen, HB1
Jensen, PB1
Jørgensen, KA1
Sivaloganathan, K1
Johnson, PA1
Bray, GP1
Williams, R5
Jones, AF1
Vale, JA1
McKenzie, K1
Riggs, JE1
Schochet, SS1
Parmar, JP1
Jones, AL1
Andrade, RJ1
Lucena, MI1
Fernández-Sánchez, MC1
Peláez, G1
O'Brien, KL1
Selanikio, JD1
Hecdivert, C1
Placide, MF1
Louis, M1
Barr, DB1
Barr, JR1
Hospedales, CJ1
Lewis, MJ1
Schwartz, B1
Philen, RM1
St Victor, S1
Espindola, J1
Needham, LL1
Denerville, K1
Leach, M1
Makris, M1
Gleeson, DC1
Preston, FE1
Ammenti, A1
Ferrante, R1
Spagna, A1
Shibata, N1
Ohmae, T1
Hoshino, N1
Minouchi, T1
Yamaji, A1
Eckardt, KU1
Willam, C1
Frei, U1
Akça, S1
Süleymanlar, I1
Tuncer, M1
Ersoy, F1
Süleymanlar, G1
Shahroor, S1
Shvil, Y1
Ohali, M1
Granot, E1
Del Vecchio, MT1
Sundel, ER1
Rosefsky, JB1
Agarwal, R1
Farber, MO1
Herrero, JL1
Castellano, I1
Gómez-Martino, JR1
Novillo, R1
Covarsí, A1
Sutherland, GR1
Park, J1
Smith, IJ1
Berndt, WO1
Wilkinson, R1
James, OF1
Roberts, SH1
Morley, AR1
Robson, V1
Smith, JM1
Roberts, WO1
Hall, SM1
White, TA1
Gilbertson, AA1
Calvert, LJ1
Linder, CW1
Abrahams, C1
Furman, KI1
Salant, D1
Wilkinson, SP2
Moodie, H1
Arroyo, VA1
Arnold, L2
Collins, C2
Starmer, GA2
Nanra, RS1
Okuonghae, HO1
Ighogboja, IS1
Lawson, JO1
Nwana, EJ1
Campbell, NR1
Baylis, B1
Mathew, TH1
Davenport, A5
Will, EJ4
Davison, AM4
Panos, MZ1
Anderson, JV1
Forbes, A1
Payne, N1
Slater, JD1
Rees, L1
Duchene, A1
Chadenas, D1
Marneffe-Lebrequier, H1
Hansen, PB1
Dalhoff, K1
Joffe, P1
Olesen, B1
Gallego, N1
Teruel, JL1
Mampaso, F1
Gonzalo, A1
Ortuño, J1
Berg, KJ1
Djøseland, O1
Gjellan, A1
Hundal, O1
Knudsen, ER1
Rugstad, HE1
Rønneberg, E1
Murray, MD1
Brater, DC1
Tierney, WM1
Hui, SL1
McDonald, CJ1
Losowsky, MS1
Forycki, Z1
Martens, F1
Thalhofer, S1
Ibe, K1
Kleinknecht, D1
Landais, P1
Goldfarb, B1
Hillebrand, G1
Mittermüller, J1
Finn, R1
Björck, S1
Svalander, CT1
Aurell, M1
Kritharides, L1
Fassett, R1
Singh, B1
Keaton, MR1
Kher, K1
Makker, S1
Clark, PM1
Clark, JD1
Wheatley, T1
Frisinette-Fich, C1
Lundberg, M1
Sörensen, J1
Pillans, P1
Hall, C1
Kaysen, GA1
Pond, SM1
Roper, MH1
Menke, DJ1
Marrama, MA1
Benson, RE1
Boleyn, T1
Dölle, W1
Barnes, P1
Prichard, JS1
Hunter, JA1
Wright, N2
Blendis, LM1
Done, AK1
Temple, AR1
Boyer, TD1
Rouff, SL1
Toghill, PJ1
Stephens, JD1
Carroll, JD1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria: A Randomised Controlled Clinical Trial[NCT03056391]Phase 3360 participants (Actual)Interventional2016-10-31Completed
An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819]256 participants (Anticipated)Observational2021-01-02Enrolling by invitation
Paracetamol Effect on Oxidative Stress and Renal Function in Severe Falciparum Malaria With Intravascular Haemolysis: A Randomised Controlled Clinical Trial[NCT01641289]62 participants (Actual)Interventional2012-07-10Completed
Effect of Acetaminophen on the Incidence of Acute Kidney Injury in Patients Undergoing Aortic Surgery With Moderate Hypothermic Circulatory Arrest[NCT04882202]136 participants (Anticipated)Interventional2021-09-01Recruiting
A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440]3,488 participants (Actual)Observational1998-01-31Completed
A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients[NCT05637216]Phase 240 participants (Anticipated)Interventional2023-08-17Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

17 reviews available for acetaminophen and Acute Kidney Injury

ArticleYear
Isolated paracetamol-induced acute kidney injury: a systematic review.
    Acute medicine, 2022, Volume: 21, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Humans; Incidence; Liver; Retrospective Studies; Risk Fac

2022
Literature review: are NSAIDs harmful and is acetaminophen well tolerated?
    Current opinion in nephrology and hypertension, 2023, 05-01, Volume: 32, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hypertension; R

2023
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury.
    Seminars in nephrology, 2020, Volume: 40, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminat

2020
The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury.
    International journal of molecular sciences, 2021, Mar-08, Volume: 22, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Humans; Inflamm

2021
Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.
    Current opinion in infectious diseases, 2018, Volume: 31, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Coma; De

2018
Long-term adverse effects of paracetamol - a review.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Asthma; Cardiovascular Diseases; Chron

2018
Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies.
    BioFactors (Oxford, England), 2019, Volume: 45, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxi

2019
[Severe toxic acute liver failure: etiology and treatment].
    Annales francaises d'anesthesie et de reanimation, 2013, Volume: 32, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde

2013
[Severe paracetamol poisoning complicated with liver and renal failure--case report and review of literature].
    Przeglad lekarski, 2012, Volume: 69, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver

2012
[Renal insufficiency caused by medicines, diagnostic processes, toxins].
    Orvosi hetilap, 2007, Jan-21, Volume: 148, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Aminoglycosides; Amphotericin B; Angiotensin II Type 1 Receptor

2007
Acute renal failure due to acetaminophen ingestion: a case report and review of the literature.
    Journal of the American Society of Nephrology : JASN, 1995, Volume: 6, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Diagnosis, Differential; Drug Overdose; Female; Humans; N

1995
Renal effects of over-the-counter analgesics.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Kid

1995
Paracetamol poisoning and the kidney.
    Journal of clinical pharmacy and therapeutics, 1993, Volume: 18, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Drug Ove

1993
Unusual complications of paracetamol poisoning.
    QJM : monthly journal of the Association of Physicians, 1997, Volume: 90, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Esophageal and Gastric Varice

1997
Renal and related cardiovascular effects of conventional and COX-2-specific NSAIDs and non-NSAID analgesics.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antihyperte

2000
Drug-induced renal disease.
    The Medical journal of Australia, 1992, May-18, Volume: 156, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Angiotensin-Converting Enzyme Inhibitors; Anti-Infla

1992
Treatment of salicylate poisoning.
    Modern treatment, 1971, Volume: 8, Issue:3

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin

1971

Trials

7 trials available for acetaminophen and Acute Kidney Injury

ArticleYear
The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022, 10-12, Volume: 75, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Creatinine; Hemoglobins; Hemolysis; Humans; Kidney; Malaria; Mal

2022
PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria.
    BMJ open, 2023, 07-31, Volume: 13, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase

2023
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 09-14, Volume: 67, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area

2018
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 09-14, Volume: 67, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area

2018
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 09-14, Volume: 67, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area

2018
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 09-14, Volume: 67, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area

2018
The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial.
    Trials, 2018, Apr-24, Volume: 19, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Antioxidants; Biomarkers; Hemolysis; Humans; Malaria; Malaysia;

2018
Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Acute-Phase Proteins; Analgesics, Non-Narcotic; Biomarkers; Card

2014
N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Animals; A

2012
Continuous vs. intermittent forms of haemofiltration and/or dialysis in the management of acute renal failure in patients with defective cerebral autoregulation at risk of cerebral oedema.
    Contributions to nephrology, 1991, Volume: 93

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Brain Edema; Female; Hemodynamics; Hemofiltration; Hepati

1991

Other Studies

155 other studies available for acetaminophen and Acute Kidney Injury

ArticleYear
Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug

2021
Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2023, Volume: 81, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Antioxidants; Cardiac Surgical Procedures; Humans; Postop

2023
Acute kidney injury after treatment of paracetamol overdose using new N-acetylcysteine guideline.
    Archives of disease in childhood, 2023, Volume: 108, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Drug-Re

2023
Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages.
    Journal of ethnopharmacology, 2020, Mar-01, Volume: 249

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Cynara scolymus

2020
Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin.
    Drug and chemical toxicology, 2022, Volume: 45, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver

2022
Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses.
    Applied microbiology and biotechnology, 2020, Volume: 104, Issue:13

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Cell Line; Cell Survival; Cytokines; Humans; Inflammaso

2020
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.
    Drug safety, 2020, Volume: 43, Issue:9

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag

2020
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats.
    Experimental animals, 2021, Feb-06, Volume: 70, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury;

2021
Concomitant Use of Acetaminophen and Aspirin Increases Risk of Kidney Injury: Analysis of the Japanese Adverse Drug Event Report Database.
    Journal of clinical pharmacology, 2021, Volume: 61, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcoti

2021
4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
    Toxicology and applied pharmacology, 2020, 12-15, Volume: 409

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Live

2020
Paracetamol use and lowered risk of acute kidney injury in patients with rhabdomyolysis.
    Journal of nephrology, 2021, Volume: 34, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Cohort Studies; Humans; Mice; Renal Replacement Therapy

2021
Flucloxacillin and paracetamol induced pyroglutamic acidosis.
    BMJ case reports, 2021, Jan-08, Volume: 14, Issue:1

    Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Aged; Anti-Bacterial Agents; Antipyretics; Bacteremia;

2021
Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Administration, Intravenous; Birth Weight; Chemical and Drug Ind

2021
Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings.
    The American journal of tropical medicine and hygiene, 2021, 05-10, Volume: 105, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Bee Venoms; Bees; Child, Pres

2021
HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2017, Volume: 22, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Biomarkers; Cisplatin; Early Diagnosis; HSP72 Heat-Shoc

2017
Mechanism of grape seeds extract protection against paracetamol renal cortical damage in male Albino rats.
    Bratislavske lekarske listy, 2017, Volume: 118, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Antioxidants; Grape Seed Extract; Male; Plant Extracts;

2017
Effect of Acetaminophen on the Prevention of Acute Kidney Injury in Patients With Sepsis.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Critical Illness; Female; Humans; Intensive Care Un

2018
Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations.
    Archives of toxicology, 2018, Volume: 92, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Animals, Genetically Modified; Gentamicins; Inactivatio

2018
Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2018, Volume: 21, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Presch

2018
Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery.
    JAMA pediatrics, 2018, 07-01, Volume: 172, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Antioxidants; Cardiac Surgical Procedures; Child, Preschool; Cre

2018
Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation.
    Kidney & blood pressure research, 2018, Volume: 43, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Electron Transport Complex I; Inflammation; Mice; Oxida

2018
Effect of Ocimum basilicum leaves extract on acetaminophen-induced nephrotoxicity in BALB/c mice.
    Journal of complementary & integrative medicine, 2018, Oct-12, Volume: 16, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Aspartate Aminotransferases; Catalase; Humans; Kidney;

2018
Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Dr

2019
Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats.
    International urology and nephrology, 2019, Volume: 51, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Analgesics, Non-Narcotic;

2019
Effectiveness and Renal Functions Safety of Treatments Used for Neonates with Patent Ductus Arteriosus: A Prospective Cohort Study.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, May-17, Volume: 25

    Topics: Acetaminophen; Acute Kidney Injury; China; Cohort Studies; Ductus Arteriosus, Patent; Female; Humans

2019
[Acute renal failure in a healthy 19-year-old woman after intake of 7 g of paracetamol].
    Ugeskrift for laeger, 2019, May-20, Volume: 181, Issue:21

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Female; Hospitalization

2019
The effects of N-acetylcysteine and ozone therapy on oxidative stress and inflammation in acetaminophen-induced nephrotoxicity model.
    Renal failure, 2013, Volume: 35, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Drug Evaluati

2013
The relationship between N-acetylcysteine, hyperbaric oxygen, and inflammation in a rat model of acetaminophen-induced nephrotoxicity.
    Inflammation, 2013, Volume: 36, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Creatinine; F

2013
[Acetaminophen (paracetamol) causing renal failure: report on 3 pediatric cases].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2013, Volume: 20, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Creatinine; Drug Overdose; Female; Follow-Up Studies

2013
Possible fatal acetaminophen intoxication with atypical clinical presentation.
    Journal of forensic sciences, 2013, Volume: 58, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Disseminated Intravascular Coagulation

2013
Oxidative stress in paracetamol-induced pathogenesis: (I). Renal damage.
    Indian journal of biochemistry & biophysics, 2005, Volume: 42, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Creatinine; Glutathione; Lipi

2005
Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice.
    Toxicology and industrial health, 2016, Volume: 32, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; F

2016
Therapeutic and protective effects of Caesalpinia gilliesii and Cajanus cajan proteins against acetaminophen overdose-induced renal damage.
    Toxicology and industrial health, 2016, Volume: 32, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Cajanus; Creatinine; Fabaceae; Kidney; Male; Plant Extr

2016
Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcoti

2014
Risk factors and outcomes of acute kidney injury in patients with acute liver failure.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015, Volume: 13, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Antipyretics; Female

2015
Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases.
    Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:14

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biopsy; Dose-Response Relations

2014
Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen.
    Pediatrics international : official journal of the Japan Pediatric Society, 2015, Volume: 57, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Child, Preschool; Female; Fever; Human

2015
Thearubigins protect against acetaminophen-induced hepatic and renal injury in mice: biochemical, histopathological, immunohistochemical, and flow cytometry study.
    Drug and chemical toxicology, 2016, Volume: 39, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Apoptosis; Camellia sinensis; Catechin; Chemical and Dr

2016
[Acute kidney injury in paracetamol poisoning].
    Medicina clinica, 2016, Mar-04, Volume: 146, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans;

2016
The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:10

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Antidotes; Chemical and Drug Induced Liver Injur

2015
Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.
    Scientific reports, 2015, Oct-22, Volume: 5

    Topics: Acetaminophen; Acute Kidney Injury; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Ind

2015
Risk of Acute Kidney Injury and Long-Term Outcome in Patients With Acetaminophen Intoxication: A Nationwide Population-Based Retrospective Cohort Study.
    Medicine, 2015, Volume: 94, Issue:46

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Databa

2015
Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 152, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Biomarkers; Case-Control Studies; Cells, Cultured; Cispla

2016
Incidence and characterization of acute kidney injury after acetaminophen overdose.
    Journal of critical care, 2016, Volume: 35

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biomarkers; Cre

2016
Effects of acetaminophen and mannitol on crush injuries in rats: An experimental study.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2016, Volume: 22, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Crush S

2016
High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study.
    BMC nephrology, 2016, 11-24, Volume: 17, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida

2016
Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 39

    Topics: Acetaminophen; Acute Kidney Injury; Biomarkers; Cadmium; Cell Line; Cell Survival; Cisplatin; Gentam

2017
A case of nonoliguric acute kidney injury associated with acetaminophen overdose.
    Southern medical journal, 2008, Volume: 101, Issue:12

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Hu

2008
Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury

2009
Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs.
    Pediatric emergency care, 2009, Volume: 25, Issue:4

    Topics: Abdominal Pain; Acetaminophen; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Child; Deh

2009
[Acute renal failure after acetaminophen poisoning: report of three cases].
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2009, Volume: 56, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Anuria; Creatinine;

2009
Acute renal failure following detergent ingestion.
    Singapore medical journal, 2009, Volume: 50, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Depression; Detergents; Eating; Female; Fluoxetine; Human

2009
Delayed onset of acute renal failure after significant paracetamol overdose: A case series.
    Human & experimental toxicology, 2010, Volume: 29, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcoti

2010
Assessing the impact of vomiting episodes on outcome after acetaminophen poisoning.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Cohort Studies; D

2010
Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication.
    Human & experimental toxicology, 2011, Volume: 30, Issue:9

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Data Interpretation, Stat

2011
Acute kidney injury in patients admitted to a liver intensive therapy unit with paracetamol-induced hepatotoxicity.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:11

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver

2011
The outcomes of critically ill patients with combined severe acute liver and kidney injury secondary to paracetamol toxicity requiring renal replacement therapy.
    Renal failure, 2011, Volume: 33, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Critical Illness;

2011
Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:8

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Female; Hemolysis; Hemolytic-Uremic Syndr

2011
Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica.
    Scandinavian journal of urology and nephrology, 2012, Volume: 46, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C

2012
Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical.
    Renal failure, 2012, Volume: 34, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Electric Stimulation; Endothelium, Vascular; Female; Fr

2012
Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats.
    Journal of Zhejiang University. Science. B, 2012, Volume: 13, Issue:3

    Topics: Acetaminophen; Acetates; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Antioxidants; Creat

2012
[Paracetamol nephropathy].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002, Volume: 22, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Apoptosis; Cells, Cultured; Humans; Kidney Tubul

2002
[Crohn's disease and renal amyloidosis. Acute renal failure].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002, Volume: 22, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Amyloidosis; Analgesics, Non-Nar

2002
[Liquid paracetamol intoxication in the under-6s: changes in the toxic dose].
    Atencion primaria, 2003, Oct-31, Volume: 32, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury

2003
In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure.
    Pediatric nephrology (Berlin, Germany), 2004, Volume: 19, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fema

2004
[Acute renal failure after paracetamol (Acetaminophen) poisoning--report of two cases].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2003, Volume: 56, Issue:11-12

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Female; Humans; Liver Failure;

2003
Acute renal dysfunction in acetaminophen poisoning.
    Renal failure, 2005, Volume: 27, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Age Distribution; Aged; Drug Overdose; Em

2005
A Friday afternoon case of apparent anti-glomerular basement nephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Animals; Anti-Glomerular Basement Membrane Disease;

2006
An unusual cause of severe metabolic acidosis.
    The Medical journal of Australia, 2006, Aug-21, Volume: 185, Issue:4

    Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Floxa

2006
Acute renal failure in a patient with familial Mediterranean fever.
    Rheumatology international, 2007, Volume: 27, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal

2007
Fatal encephalopathy and renal failure caused by diethylene glycol poisoning.
    Journal of tropical pediatrics, 2006, Volume: 52, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Child, Preschool; Drug Contamination; Ethylene Glycols; Fatal Ou

2006
Accidental paracetamol poisoning.
    The Medical journal of Australia, 2007, Apr-02, Volume: 186, Issue:7

    Topics: Abdominal Pain; Accidents; Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Fatal Outco

2007
Therapeutic dose of acetaminophen with fatal hepatic necrosis and acute renal failure.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Autopsy; Fatal Outcome; Female;

2007
Acute renal failure after acetaminophen ingestion.
    JAMA, 1982, Feb-19, Volume: 247, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Amylases; Creatine Kinase; Female; Humans; Liver; Pain; T

1982
Anion gap acidosis with hypoglycemia in acetaminophen toxicity.
    Annals of emergency medicine, 1984, Volume: 13, Issue:10

    Topics: Acetaminophen; Acid-Base Imbalance; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced

1984
[Paracetamol poisoning--clinical aspects and pharmacokinetics].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1983, Sep-01, Volume: 38, Issue:17

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcohol Drinking; Chemical and Drug Induced Liver Injury;

1983
[Therapeutic intake of paracetamol caused acute renal insufficiency and liver damage].
    Lakartidningen, 1984, Mar-28, Volume: 81, Issue:13

    Topics: Acetaminophen; Acute Kidney Injury; Humans; Liver; Male; Middle Aged

1984
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
    British medical journal (Clinical research ed.), 1982, Jan-02, Volume: 284, Issue:6308

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Femal

1982
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
    British medical journal (Clinical research ed.), 1982, Feb-06, Volume: 284, Issue:6313

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; M

1982
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
    British medical journal (Clinical research ed.), 1982, Feb-13, Volume: 284, Issue:6314

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Humans; Male

1982
Paracetamol-induced acute renal failure.
    British medical journal (Clinical research ed.), 1982, Mar-13, Volume: 284, Issue:6318

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Cysteamine; Female; Humans

1982
[Acute kidney insufficiency following paracetamol poisoning].
    Nederlands tijdschrift voor geneeskunde, 1983, Jun-11, Volume: 127, Issue:24

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Female; Humans; Kidney Tubular Necrosis, Acute; Kidney Tu

1983
Acetaminophen and its toxicity.
    Journal of applied toxicology : JAT, 1983, Volume: 3, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Cats; Chemical and Drug Induced Liver I

1983
Colorimetry of serum acetaminophen (paracetamol) in uremia.
    Clinical chemistry, 1982, Volume: 28, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Colorimetry; Ethers; False Positive Reactions; Humans; Reference

1982
Acute tubular necrosis, caused by therapeutic doses of paracetamol?
    Clinical nephrology, 1982, Volume: 18, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Biopsy; Humans; Kidney; Kidney Tubular Necrosis, Acute; M

1982
Acute renal failure after acetaminophen overdose: report of two cases.
    American journal of hospital pharmacy, 1981, Volume: 38, Issue:9

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Female; Humans; Kidney Tubular Necrosis, Acute

1981
Alcoholism, nonprescription drug and hepatotoxicity. The risk from unknown acetaminophen ingestion.
    The American journal of gastroenterology, 1981, Volume: 76, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Femal

1981
Acetaminophen associated hepatic injury, Report of two cases showing unusual portal tract reactions.
    Human pathology, 1980, Volume: 11, Issue:1

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Alcoholism; Biopsy; Chemical and Drug Indu

1980
Acute renal failure associated with acetaminophen ingestion: report of a case and review of the literature.
    Clinical nephrology, 1980, Volume: 14, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Humans; Kidney; Kidney Tubular Necrosis, Acute; Liver; Ma

1980
Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic.
    BMJ (Clinical research ed.), 1995, Jul-08, Volume: 311, Issue:6997

    Topics: Acetaminophen; Acute Kidney Injury; Bangladesh; Child; Child, Preschool; Disease Outbreaks; Drug Con

1995
Spontaneous remission of paracetamol induced acute renal failure.
    Clinical nephrology, 1995, Volume: 43, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Female; Huma

1995
Acute lung injury in fulminant hepatic failure following paracetamol poisoning.
    Thorax, 1995, Volume: 50, Issue:4

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; APACHE; Female; Hepatic Encephalopathy; Hu

1995
Acute renal failure associated with paracetamol ingestion in an alcoholic patient.
    Nephron, 1994, Volume: 67, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Adult; Alcoholism; Ethanol; Humans; Male

1994
Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen overdosing.
    Clinical pediatrics, 1994, Volume: 33, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Child, P

1994
[Acute renal failure caused by paracetamol poisoning].
    Ugeskrift for laeger, 1993, May-31, Volume: 155, Issue:22

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Humans; Male; Renal Dialysis

1993
Pericoronitis and accidental paracetamol overdose: a cautionary tale.
    British dental journal, 1993, Jan-23, Volume: 174, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Cystine; Dextropropoxyphene; Drug Combinations; Drug Over

1993
Epidemic of acute renal failure in Haiti.
    BMJ (Clinical research ed.), 1996, Jul-13, Volume: 313, Issue:7049

    Topics: Acetaminophen; Acute Kidney Injury; Disease Outbreaks; Drug Contamination; Haiti; Humans

1996
Fatalities associated with ingestion of diethylene glycol-contaminated glycerin used to manufacture acetaminophen syrup--Haiti, November 1995-June 1996.
    MMWR. Morbidity and mortality weekly report, 1996, Aug-02, Volume: 45, Issue:30

    Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Adolescent; Child; Child, Preschool; Disea

1996
Rhabdomyolysis with acute renal failure and disseminated intravascular coagulation: association with acetaminophen and ethanol.
    Military medicine, 1996, Volume: 161, Issue:11

    Topics: Acetaminophen; Acute Kidney Injury; Alcohol Drinking; Disseminated Intravascular Coagulation; Ethano

1996
[Hepatotoxicity caused by paracetamol at therapeutic doses].
    Medicina clinica, 1997, Sep-13, Volume: 109, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Humans; Liver

1997
Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team.
    JAMA, 1998, Apr-15, Volume: 279, Issue:15

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Anuria; Case-Control Studies; Child; Child, Preschoo

1998
Acute liver failure induced by alcohol and paracetamol in an HCV-infected haemophiliac.
    British journal of haematology, 1998, Volume: 103, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Hemophilia B;

1998
Diethylene glycol poisoning associated with paracetamol liquid formulations.
    Adverse drug reactions and toxicological reviews, 1998, Volume: 17, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemistry, Pharmaceutical; Child; Child, Preschool;

1998
Renal impairment without hepatic damage after acetaminophen overdose.
    Pediatric nephrology (Berlin, Germany), 1999, Volume: 13, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Charcoal; Drug Overdose; Female; Hum

1999
Influence of glycerol-induced acute renal failure on the pharmacokinetics of cyclosporin in rats.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Analgesics, Non-Narcotic; Animals; Area Un

1999
Severe hypophosphataemia in paracetamol-induced oliguric renal failure.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Female; Humans; Hypophosphatemi

1999
Isolated acute renal failure due to paracetamol intoxication in an alcoholic patient.
    Nephron, 1999, Volume: 83, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Analgesics, Non-Narcotic; Humans; Male

1999
[Acetaminophen toxicity in children as a "therapeutic misadventure"].
    Harefuah, 2000, Apr-16, Volume: 138, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Child, Preschool; Female; Human

2000
Alternating antipyretics: is this an alternative?
    Pediatrics, 2001, Volume: 108, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Drug Synerg

2001
Alternating antipyretics: is this an alternative?
    Pediatrics, 2001, Volume: 108, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Administration Schedule; Drug Int

2001
Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile?
    Clinical nephrology, 2002, Volume: 57, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Hemo

2002
[Acute kidney failure caused by paracetamol poisoning].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2001, Volume: 21, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Blood Coagulation Tests; Chemical and Drug Induced Liver

2001
Letter: Toxicity of paracetamol.
    Lancet (London, England), 1976, Jan-24, Volume: 1, Issue:7952

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Death, Sudden; Humans; Rats

1976
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
    Lancet (London, England), 1976, Jul-17, Volume: 2, Issue:7977

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury;

1976
Effects of toxic chemicals on renal transport processes.
    Federation proceedings, 1979, Volume: 38, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Biological Transport; Citrinin; Dogs; Kidney; Kidney Co

1979
Plasma renin activity during the development of paracetamol (acetaminophen) induced acute renal failure in man.
    Clinical nephrology, 1979, Volume: 11, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Creatinine; Hepatic Encephalopathy; Humans; K

1979
Late treatment of paracetamol poisoning with mercaptamine.
    British medical journal, 1978, Feb-11, Volume: 1, Issue:6109

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury;

1978
Acetaminophen poisoning.
    The Journal of family practice, 1978, Volume: 7, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Female; Humans; Infant;

1978
Dermal micro-angiopathy in patients with analgesic nephropathy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1978, Sep-02, Volume: 54, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Capillaries; Female; Humans; Kidney Failure, Chroni

1978
Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage.
    Journal of clinical pathology, 1977, Volume: 30, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Endotoxins; Hepatitis, V

1977
Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.
    Pathology, 1976, Volume: 8, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Aspirin; Dinitrophenols; Female; Kidney Tubular Necrosi

1976
Analgesic nephropathy.
    The Medical journal of Australia, 1976, May-15, Volume: 1, Issue:20

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Co

1976
Diethylene glycol poisoning in Nigerian children.
    Annals of tropical paediatrics, 1992, Volume: 12, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Drug Contamination; Ethylene Glycols; Female; Humans; Infant; Ma

1992
Renal impairment associated with an acute paracetamol overdose in the absence of hepatotoxicity.
    Postgraduate medical journal, 1992, Volume: 68, Issue:796

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Drug Overdose; Female; Humans; Kidney

1992
Human atrial natriuretic factor and renin-aldosterone in paracetamol induced fulminant hepatic failure.
    Gut, 1991, Volume: 32, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Albumins; Aldosterone; Atrial Function,

1991
[Isolated acute kidney failure after attempted suicide with paracetamol].
    Presse medicale (Paris, France : 1983), 1991, Oct-26, Volume: 20, Issue:34

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Humans; Male; Suicide, Attempted

1991
Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma.
    Scandinavian journal of gastroenterology, 1991, Volume: 26, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; beta 2-Microglobulin; Diagnosis, Differential; Fema

1991
Acute interstitial nephritis superimposed on glomerulonephritis: report of a case.
    Pediatric nephrology (Berlin, Germany), 1991, Volume: 5, Issue:2

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Child; Glomerulonephritis; Hematuria; Humans; Mal

1991
Acute effects of paracetamol on prostaglandin synthesis and renal function in normal man and in patients with renal failure.
    Clinical nephrology, 1990, Volume: 34, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Age Factors; Aged; Creatinine; Dinoprostone; Female; Glom

1990
Effect of posture on intracranial pressure and cerebral perfusion pressure in patients with fulminant hepatic and renal failure after acetaminophen self-poisoning.
    Critical care medicine, 1990, Volume: 18, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Blood Pressure; Brain Edema; Cerebrovascular Circulation;

1990
Ibuprofen-associated renal impairment in a large general internal medicine practice.
    The American journal of the medical sciences, 1990, Volume: 299, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Fema

1990
Rebound surges of intracranial pressure as a consequence of forced ultrafiltration used to control intracranial pressure in patients with severe hepatorenal failure.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1989, Volume: 14, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Brain Edema; Drug Overdose; Female; Hemofiltration; Hepat

1989
Are changes in intracranial pressure during intermittent machine haemofiltration dependent upon membrane biocompatibility?
    The International journal of artificial organs, 1989, Volume: 12, Issue:11

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Biocompatible Materials; Female; Hemofiltration; Humans;

1989
Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis.
    Blood purification, 1985, Volume: 3, Issue:1-3

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Anxiety Agents; Antidepressive Agents; Benzodia

1985
Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study.
    Clinical nephrology, 1986, Volume: 25, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents; Biopsy; Female; Glafenine;

1986
[Hemolysis, methemoglobinemia and renal failure in a 30-year-old patient].
    Der Internist, 1988, Volume: 29, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics; Anemia, Hemolytic; Female; Humans; Kidney; Me

1988
Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma.
    Nephron, 1988, Volume: 50, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Female; Hepatic Encephalopathy; Humans; K

1988
Acute renal failure after analgesic drugs including paracetamol (acetaminophen).
    Nephron, 1988, Volume: 49, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics; Biopsy; Humans; Kidney; Kidney Tu

1988
Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.
    Intensive care medicine, 1988, Volume: 14, Issue:4

    Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Coma; F

1988
Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion.
    Southern medical journal, 1988, Volume: 81, Issue:9

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Headache; Humans; Kidney Tubular Necrosis, Ac

1988
Acute renal failure due to acetaminophen ingestion without concurrent hepatotoxicity.
    The American journal of medicine, 1987, Volume: 82, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Female; Huma

1987
Urine discoloration after acetaminophen overdose.
    Clinical chemistry, 1986, Volume: 32, Issue:9

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Aminophenols; Chemical and Drug Induced Liver Injury; Chr

1986
[He ended his fasting with wine and paracetamol. The patient's liver and kidney were damaged].
    Lakartidningen, 1986, Aug-20, Volume: 83, Issue:34

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Fasting; Humans; Kidney; Liver; Male; Wine

1986
Paracetamol-induced acute renal failure in the absence of severe liver damage.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, May-17, Volume: 67, Issue:20

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Female; Huma

1985
Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen.
    Archives of internal medicine, 1985, Volume: 145, Issue:11

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Diagn

1985
Paracetamol overdose: a plan of management.
    Anaesthesia and intensive care, 1974, Volume: 2, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury;

1974
[Liver damage following paracetamole poisoning].
    Der Internist, 1972, Volume: 13, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Autopsy; Blood Sedimentation; Chemical and Drug Induced

1972
Self-poisoning with paracetamol.
    British medical journal, 1972, Nov-18, Volume: 4, Issue:5837

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Dr

1972
Toxic epidermal necrolysis associated with pentazocine therapy and severe reversible renal failure.
    The British journal of dermatology, 1973, Volume: 88, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Blood Cells; Blood Pressure; Chlorpheniramine; Cloxacillin; Dext

1973
The short-term effects of analgesics on the kidney with special reference to acetylsalicylic acid.
    Pathology, 1973, Volume: 5, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Animals; Aspirin; Caffeine; Dose-Response

1973
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study.
    British journal of pharmacology, 1973, Volume: 49, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotr

1973
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
    British medical journal, 1974, Feb-02, Volume: 1, Issue:5900

    Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin

1974
Acetaminophen-induced hepatic necrosis and renal failure.
    JAMA, 1971, Oct-18, Volume: 218, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; H

1971
Acute paracetamol poisoning.
    British medical journal, 1970, Sep-05, Volume: 3, Issue:5722

    Topics: Acetaminophen; Acidosis; Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and D

1970
Acute hepatic necrosis following an overdose of paracetamol.
    Gastroenterology, 1969, Volume: 56, Issue:4

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Bilirubin; Blood Glucose; Chemical and Dru

1969