acetaminophen and Acute Disease studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

Excerpt	Relevance	Reference
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."	9.51	The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al."	9.22	Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. ( Gottlieb, M; Njie, A, 2016)
"The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED)."	9.19	Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial. ( Eken, C; Elicabuk, H; Erdal, M; Serinken, M; Uyanik, E, 2014)
"9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0."	9.19	Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014)
"A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care."	9.15	A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011)
"In this double-blind cross-over study, we assessed whether erythromycin infusion is effective as a prokinetic drug against gastroparesis from acute pain."	9.12	Erythromycin promotes gastric emptying during acute pain in volunteers. ( Allaouchiche, B; Bleyzac, N; Boselli, E; Bouvet, L; Chassard, D; Duflo, F; Mion, F, 2006)
"The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC)."	9.12	Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. ( Bey, M; Burnett, I; Grattan, T; Littlejohn, S; Sanner, K; Schachtel, B, 2006)
"Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries."	9.12	A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007)
"An intravenous formulation of paracetamol and an intravenous formulation of propacetamol (prodrug of paracetamol) were compared in children with acute fever due to infection in order to determine the antipyretic efficacy and safety during the 6-hour period after administration."	9.12	Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. ( Dalphin, ML; Duhamel, JF; Le Gall, E; Payen-Champenois, C, 2007)
"To determine the efficiency of drugs, which include antihistaminic-decongestant-acetaminophen agents versus only acetaminophen in symptomatic treatment of acute nasopharyngitis in children."	9.12	Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relieving symptoms of acute nasopharyngitis in children? A randomised, controlled trial. ( Aslan, SS; Aydin, S; Badur, S; Kilic, A; Oguz, F; Sidal, M; Toprak, S; Unuvar, E; Yildiz, I, 2007)
"240 patients with acute low back pain who had seen their general practitioner and had been given advice and paracetamol were randomly allocated to one of four groups in our community-based study: diclofenac 50 mg twice daily and placebo manipulative therapy (n=60); spinal manipulative therapy and placebo drug (n=60); diclofenac 50 mg twice daily and spinal manipulative therapy (n=60); or double placebo (n=60)."	9.12	Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. ( Cooper, CW; Day, RO; Hancock, MJ; Latimer, J; Maher, CG; McAuley, JH; McLachlan, AJ; Spindler, MF, 2007)
"In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia."	9.11	Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004)
"In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of >or= 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (singledose phase) followed by 5/325 mg every 6h as needed (multidose phase), or placebo."	9.11	Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. ( Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA, 2004)
"To compare the safety and efficacy of a new cyclooxygenase-2 inhibitor, valdecoxib, with those of an oxycodone-acetaminophen combination in patients with acute musculoskeletal pain."	9.11	Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. ( Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A, 2004)
"Aspirin (acetylsalicylic acid) and acetaminophen (paracetamol) are frequently used to treat fever and other symptoms of upper respiratory tract infection (URTI)."	9.11	Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st ( Bachert, C; Chuchalin, AG; Eisebitt, R; Netayzhenko, VZ; Voelker, M, 2005)
" In a previous randomized trial we observed that treatment with high-dose acetaminophen (paracetamol) led to a reduction of body temperature in patients with acute ischemic stroke, even when they had no fever."	9.10	Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke."	9.10	Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT."	9.10	Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002)
"To compare the efficacy of continuous low-level heat wrap therapy (40 C, 8 hours/day) with that of ibuprofen (1200 mg/day) and acetaminophen (4000 mg/day) in subjects with acute nonspecific low back pain."	9.10	Continuous low-level heat wrap therapy provides more efficacy than Ibuprofen and acetaminophen for acute low back pain. ( Abeln, SB; Beth Goodale, M; Erasala, GN; Hengehold, DA; Hinkle, RT; Nadler, SF; Steiner, DJ; Weingand, KW, 2002)
"The purpose of this preliminary study was to compare acetaminophen to ketorolac for treating patients with fever in the emergency department (ED)."	9.09	Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. ( Ernst, A; Houry, D; Ledbetter, M; Weiss, S, 1999)
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)."	9.09	Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999)
"Seventy-five patients with acute ischemic stroke confined to the anterior circulation were randomized to treatment with either 500 mg (low dose) or 1000 mg (high dose) acetaminophen or with placebo, administered as suppositories 6 times daily during 5 days."	9.09	Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001)
"Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double-blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of ibuprofen (IBU) in the treatment of 1 to 6 year-old children with otoscopically proven acute otitis media (AOM), either unilateral or bilateral."	9.08	A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. ( Bertin, L; d'Athis, P; Debregeas, B; Duhamel, JF; Guillot, M; Lasfargues, G; Marsac, A; Maudelonde, C; Olive, G; Pons, G, 1996)
"To evaluate the efficacy of an oral tramadol preparation versus that of an oral hydrocodone-acetaminophen preparation in acute musculoskeletal pain."	9.08	Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. ( Larkin, GL; Paris, PM; Turturro, MA, 1998)
"In a randomized, double-blind prospective manner, patients received either 5 mg hydrocodone with 500 mg acetaminophen or 30 mg codeine with 500 mg acetaminophen to take on discharge from the ED and every four hours thereafter as needed for pain."	9.07	Hydrocodone versus codeine in acute musculoskeletal pain. ( Menegazzi, JJ; Paris, PM; Turturro, MA; Yealy, DM, 1991)
"A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo."	9.05	A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982)
"The present randomized single-blind trial was performed to study antipyretic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories versus paracetamol (acetaminophen) suppositories in pediatric patients with fever of various etiology."	9.05	Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. ( Michos, N; Stocker, H; Sundal, EJ; Weippl, G, 1985)
"The hypothesis that schizophrenia is caused by the release of prostaglandin E into the hypothalamus and may sometimes be accompanied by an elevation of temperature was examined by a clinical trial of the prostaglandin E suppressant N-acetyl-p-amino-phenol (paracetamol, acetaminophen)."	9.04	N-acetyl-p-amino-phenol (paracetamol, acetaminophen) in the treatment of acute schizophrenia. ( Falloon, I; Lubbe, K; MacDonald, A; Shepherd, M; Watt, DC, 1978)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."	8.93	Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."	8.89	Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."	8.86	Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010)
"Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year."	8.82	Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. ( Lee, WM, 2004)
"The inclusion criteria were: full journal publication, clinical trial, random allocation of adult patients to treatment groups, double blind design, moderate to severe baseline pain, postoperative administration of study drugs, treatment arms which included oxycodone or oxycodone plus paracetamol and placebo (or active control for which comparable efficacy data exist), and oral, intramuscular or intravenous administration of study drugs."	8.80	Single dose oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain. ( Edwards, JE; McQuay, HJ; Moore, RA, 2000)
"In order to assess the analgesia obtained from single oral doses of paracetamol alone and in combination with codeine in postoperative pain, we conducted a systematic review of randomised controlled trials."	8.79	Paracetamol with and without codeine in acute pain: a quantitative systematic review. ( Carroll, D; Collins, S; McQuay, H; Moore, A, 1997)
"Here we present the case of a young female with a delayed onset acetaminophen-induced pancreatitis."	7.80	Acetaminophen-induced pancreatic pseudocyst: first case report. ( Cavanaugh, Z; Naut, ER, 2014)
"Trials in acute postoperative pain are usually small."	7.80	Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain. ( Edwards, J; McQuay, H, 2003)
"Metabolic acidosis after acute acetaminophen overdose is typically attributed to either transient lactic acidosis without evidence of hepatic injury or hepatic failure."	7.76	5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose. ( Bechtel, LK; Charlton, NP; Holstege, CP; Lawrence, DT, 2010)
"The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)."	7.74	Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007)
"Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States."	7.74	Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007)
"In acute poisoning caused by acetaminophen (N-acetyl-p-aminophenol, APAP), it is critical to predict the onset of delayed liver injury based on the prompt measurement of serum APAP level and to administer the antidote N-acetylcysteine (NAC) without delay as needed."	7.74	[Clinical usefulness of the acetaminophen detection kit in treating acute poisoning--data from a survey of 28 cases treated at Niigata City general hospital]. ( Fujisawa, M; Hirose, Y; Hori, Y; Katsuyama, S; Oda, A; Takayama, M; Wakabayashi, H; Yamazaki, K, 2008)
"Acute liver failure was induced in SCID mice by intraperitoneal injection of 400 mg/kg acetaminophen."	7.74	Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. ( Kasai, N; Kiyono, T; Matsumoto, S; Matsushita, M; Takahashi, T; Todo, S; Tsuruga, Y, 2008)
"Children frequently suffer infections accompanied by fever, which is commonly treated with acetaminophen (paracetamol), a use not devoid of risk."	7.73	The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study. ( Derasse, M; Klein, P; Weiser, M, 2005)
"The possible interference of acetaminophen, combined with antibiotics, in the treatment of acute otitis media (AOM) caused by a penicillin-resistant (minimal inhibitory concentration [MIC], 2 microg/mL), amoxicillin/clavulanic acid- and erythromycin-sensitive pneumococcus was evaluated in a gerbil model."	7.72	Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. ( Aguilar, L; Carcas, A; Cenjor, C; Garcia-Olmos, M; Gimenez, MJ; Parra, A; Ponte, C; Soriano, F, 2003)
"The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure."	7.71	A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002)
"Drug-induced acute liver failure (ALF) is a devastating and often fatal disease mainly caused by poisoning by acetaminophen (APAP)."	7.71	Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse. ( Batteux, F; Calmus, Y; Ferret, PJ; Hammoud, R; Jaffray, P; Malassagne, B; Tran, A; Trébéden, H; Tulliez, M; Weill, B, 2001)
"The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)."	7.69	Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996)
"This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose."	7.68	Acetaminophen induced pancreatitis. ( Caraccio, TR; Mofenson, HC; Nawaz, H; Steckler, G, 1991)
"Acute carbon tetrachloride poisoning in 19 patients was confirmed by means of laboratory analysis of blood specimens."	7.67	Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment. ( Flanagan, RJ; Mant, TG; Ruprah, M, 1985)
"The acetaminophen group had lower pain scores on Day 1 (2."	6.69	Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. ( Fox, L; McGuinnety, M; Schug, SA; Sidebotham, DA; Thomas, J, 1998)
"Tiaprofenic acid (Surgam) is a non steroidal anti-inflammatory drug used for acute inflammation during episode of upper respiratory tract infection in adults."	6.67	[Efficacy and tolerability of tiaprofenic acid (Surgam) in acute sinusitis in adults. Results of a randomized study versus paracetamol and placebo]. ( Frachet, B; Genes, N; Rezvani, Y, 1991)
"Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine."	6.66	Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986)
" The average lengths of treatment and stay for IV dosing were 23."	6.47	Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. ( Blackford, MG; Felter, T; Gothard, MD; Reed, MD, 2011)
"Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events."	6.43	Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005)
"This could be shown for dental but not postsurgical pain, because more patients were available for the former."	6.41	Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. ( Edwards, JE; McQuay, HJ; Moore, RA, 2002)
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."	5.51	The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI)."	5.33	Role of acetaminophen in acute myocardial infarction. ( Gorman, JH; Gorman, RC; Hinmon, R; Jackson, BM; Leshnower, BG; Parish, LM; Plappert, T; Sakamoto, H; Zeeshan, A, 2006)
"In this study, the analgesic effectiveness of tramadol, a synthetic opioid, was compared with paracetamol and dexketoprofen in adult patients with acute pancreatitis in the emergency department."	5.22	Pain treatment in patients with acute pancreatitis: A randomized controlled trial. ( Dur, A; Gülen, B; Karcıoğlu, Ö; Serinken, M; Sönmez, E, 2016)
"Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al."	5.22	Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. ( Gottlieb, M; Njie, A, 2016)
"The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED)."	5.19	Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial. ( Eken, C; Elicabuk, H; Erdal, M; Serinken, M; Uyanik, E, 2014)
"9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0."	5.19	Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014)
"Acetaminophen alone may not be as effective in reducing pain-related physiological and behavioral changes as acetaminophen plus codeine or ibuprofen plus midazolam during diagnostic tympanocentesis."	5.15	Pain management in young children undergoing diagnostic tympanocentesis. ( Chandra, A; Colborn, DK; Hoberman, A; Hooper, EG; Kurs-Lasky, M; Reis, EC; Rockette, HE; Shaikh, N, 2011)
"A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care."	5.15	A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011)
"In this double-blind cross-over study, we assessed whether erythromycin infusion is effective as a prokinetic drug against gastroparesis from acute pain."	5.12	Erythromycin promotes gastric emptying during acute pain in volunteers. ( Allaouchiche, B; Bleyzac, N; Boselli, E; Bouvet, L; Chassard, D; Duflo, F; Mion, F, 2006)
"The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC)."	5.12	Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. ( Bey, M; Burnett, I; Grattan, T; Littlejohn, S; Sanner, K; Schachtel, B, 2006)
"Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries."	5.12	A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007)
"An intravenous formulation of paracetamol and an intravenous formulation of propacetamol (prodrug of paracetamol) were compared in children with acute fever due to infection in order to determine the antipyretic efficacy and safety during the 6-hour period after administration."	5.12	Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. ( Dalphin, ML; Duhamel, JF; Le Gall, E; Payen-Champenois, C, 2007)
"To determine the efficiency of drugs, which include antihistaminic-decongestant-acetaminophen agents versus only acetaminophen in symptomatic treatment of acute nasopharyngitis in children."	5.12	Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relieving symptoms of acute nasopharyngitis in children? A randomised, controlled trial. ( Aslan, SS; Aydin, S; Badur, S; Kilic, A; Oguz, F; Sidal, M; Toprak, S; Unuvar, E; Yildiz, I, 2007)
"240 patients with acute low back pain who had seen their general practitioner and had been given advice and paracetamol were randomly allocated to one of four groups in our community-based study: diclofenac 50 mg twice daily and placebo manipulative therapy (n=60); spinal manipulative therapy and placebo drug (n=60); diclofenac 50 mg twice daily and spinal manipulative therapy (n=60); or double placebo (n=60)."	5.12	Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. ( Cooper, CW; Day, RO; Hancock, MJ; Latimer, J; Maher, CG; McAuley, JH; McLachlan, AJ; Spindler, MF, 2007)
"In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia."	5.11	Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004)
"In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of >or= 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (singledose phase) followed by 5/325 mg every 6h as needed (multidose phase), or placebo."	5.11	Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. ( Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA, 2004)
"To compare the safety and efficacy of a new cyclooxygenase-2 inhibitor, valdecoxib, with those of an oxycodone-acetaminophen combination in patients with acute musculoskeletal pain."	5.11	Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. ( Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A, 2004)
"To compare the analgesic effect of single doses of etoricoxib 120 mg, oxycodone/ acetaminophen 10 mg/650 mg and codeine/ acetaminophen 60 mg/600 mg in acute pain using the dental impaction model."	5.11	The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain. ( Ang, J; Fricke, JR; Malmstrom, K; Reicin, A; Shingo, S, 2005)
"Evaluate aspirin challenge as a means to distinguish single from multiple NSAID intolerance in patients with a clinical history of acute urticaria induced by a single NSAID."	5.11	Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs. ( Asero, R, 2005)
"Aspirin (acetylsalicylic acid) and acetaminophen (paracetamol) are frequently used to treat fever and other symptoms of upper respiratory tract infection (URTI)."	5.11	Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st ( Bachert, C; Chuchalin, AG; Eisebitt, R; Netayzhenko, VZ; Voelker, M, 2005)
" In a previous randomized trial we observed that treatment with high-dose acetaminophen (paracetamol) led to a reduction of body temperature in patients with acute ischemic stroke, even when they had no fever."	5.10	Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke."	5.10	Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT."	5.10	Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002)
"To compare the efficacy of continuous low-level heat wrap therapy (40 C, 8 hours/day) with that of ibuprofen (1200 mg/day) and acetaminophen (4000 mg/day) in subjects with acute nonspecific low back pain."	5.10	Continuous low-level heat wrap therapy provides more efficacy than Ibuprofen and acetaminophen for acute low back pain. ( Abeln, SB; Beth Goodale, M; Erasala, GN; Hengehold, DA; Hinkle, RT; Nadler, SF; Steiner, DJ; Weingand, KW, 2002)
"To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever."	5.09	The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999)
"The purpose of this preliminary study was to compare acetaminophen to ketorolac for treating patients with fever in the emergency department (ED)."	5.09	Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. ( Ernst, A; Houry, D; Ledbetter, M; Weiss, S, 1999)
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)."	5.09	Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999)
"Seventy-five patients with acute ischemic stroke confined to the anterior circulation were randomized to treatment with either 500 mg (low dose) or 1000 mg (high dose) acetaminophen or with placebo, administered as suppositories 6 times daily during 5 days."	5.09	Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001)
"Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double-blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of ibuprofen (IBU) in the treatment of 1 to 6 year-old children with otoscopically proven acute otitis media (AOM), either unilateral or bilateral."	5.08	A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. ( Bertin, L; d'Athis, P; Debregeas, B; Duhamel, JF; Guillot, M; Lasfargues, G; Marsac, A; Maudelonde, C; Olive, G; Pons, G, 1996)
"To evaluate the efficacy of an oral tramadol preparation versus that of an oral hydrocodone-acetaminophen preparation in acute musculoskeletal pain."	5.08	Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. ( Larkin, GL; Paris, PM; Turturro, MA, 1998)
"In a randomized, double-blind prospective manner, patients received either 5 mg hydrocodone with 500 mg acetaminophen or 30 mg codeine with 500 mg acetaminophen to take on discharge from the ED and every four hours thereafter as needed for pain."	5.07	Hydrocodone versus codeine in acute musculoskeletal pain. ( Menegazzi, JJ; Paris, PM; Turturro, MA; Yealy, DM, 1991)
"A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo."	5.05	A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982)
"Patients with osteoarthritis were entered into a single-blind trial comparing the effects on the gastric mucosa of a four week course of indomethacin, sulindac and a compound of paracetamol and dextropropoxyphene (Distalgesic)."	5.05	Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa. ( Irani, MS; McIntyre, RL; Piris, J, 1981)
"The present randomized single-blind trial was performed to study antipyretic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories versus paracetamol (acetaminophen) suppositories in pediatric patients with fever of various etiology."	5.05	Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. ( Michos, N; Stocker, H; Sundal, EJ; Weippl, G, 1985)
"The hypothesis that schizophrenia is caused by the release of prostaglandin E into the hypothalamus and may sometimes be accompanied by an elevation of temperature was examined by a clinical trial of the prostaglandin E suppressant N-acetyl-p-amino-phenol (paracetamol, acetaminophen)."	5.04	N-acetyl-p-amino-phenol (paracetamol, acetaminophen) in the treatment of acute schizophrenia. ( Falloon, I; Lubbe, K; MacDonald, A; Shepherd, M; Watt, DC, 1978)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."	4.93	Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."	4.89	Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."	4.86	Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010)
"To assess benefits and harms of acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, benzodiazepines, antiepileptic drugs, skeletal muscle relaxants, opioid analgesics, tramadol, and systemic corticosteroids for acute or chronic low back pain (with or without leg pain)."	4.84	Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. ( Chou, R; Huffman, LH, 2007)
"Paracetamol (acetaminophen) has been shown to be an effective analgesic for the treatment of moderate pain where it is chiefly indicated, as shown in placebo-controlled studies in the perioperative setting and other acute pain states."	4.82	[Role of paracetamol in the acute pain management]. ( Kehlet, H; Werner, MU, 2003)
"Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year."	4.82	Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. ( Lee, WM, 2004)
" More common and serious poisonings caused by paracetamol, salicylates, opioids, tricyclic antidepressants, selective serotonin reuptake inhibitors, benzodiazepines, non-steroidal anti-inflammatory drugs, and cocaine are discussed in detail."	4.82	Acute poisoning: understanding 90% of cases in a nutshell. ( Dargan, PI; Greene, SL; Jones, AL, 2005)
"The inclusion criteria were: full journal publication, clinical trial, random allocation of adult patients to treatment groups, double blind design, moderate to severe baseline pain, postoperative administration of study drugs, treatment arms which included oxycodone or oxycodone plus paracetamol and placebo (or active control for which comparable efficacy data exist), and oral, intramuscular or intravenous administration of study drugs."	4.80	Single dose oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain. ( Edwards, JE; McQuay, HJ; Moore, RA, 2000)
"In order to assess the analgesia obtained from single oral doses of paracetamol alone and in combination with codeine in postoperative pain, we conducted a systematic review of randomised controlled trials."	4.79	Paracetamol with and without codeine in acute pain: a quantitative systematic review. ( Carroll, D; Collins, S; McQuay, H; Moore, A, 1997)
"Paracetamol (acetaminophen) is widely used for management of mild-to-moderate pain and reduction of fever."	3.91	Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol. ( Dosenovic, S; Margan Koletic, Z; Puljak, L, 2019)
"Here we present the case of a young female with a delayed onset acetaminophen-induced pancreatitis."	3.80	Acetaminophen-induced pancreatic pseudocyst: first case report. ( Cavanaugh, Z; Naut, ER, 2014)
"Trials in acute postoperative pain are usually small."	3.80	Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain. ( Edwards, J; McQuay, H, 2003)
" After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection."	3.79	TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013)
" For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure."	3.79	Acetaminophen-induced acute liver injury in HCV transgenic mice. ( Boorman, GA; Bradford, BU; Chatterjee, S; Jeannot, E; Kosyk, O; Macdonald, JM; Mason, RP; Melnyk, SB; Pogribny, IP; Rusyn, I; Tech, K; Tryndyak, VP; Uehara, T, 2013)
"Metabolic acidosis after acute acetaminophen overdose is typically attributed to either transient lactic acidosis without evidence of hepatic injury or hepatic failure."	3.76	5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose. ( Bechtel, LK; Charlton, NP; Holstege, CP; Lawrence, DT, 2010)
"The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)."	3.74	Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007)
"Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States."	3.74	Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007)
"In acute poisoning caused by acetaminophen (N-acetyl-p-aminophenol, APAP), it is critical to predict the onset of delayed liver injury based on the prompt measurement of serum APAP level and to administer the antidote N-acetylcysteine (NAC) without delay as needed."	3.74	[Clinical usefulness of the acetaminophen detection kit in treating acute poisoning--data from a survey of 28 cases treated at Niigata City general hospital]. ( Fujisawa, M; Hirose, Y; Hori, Y; Katsuyama, S; Oda, A; Takayama, M; Wakabayashi, H; Yamazaki, K, 2008)
"Acute liver failure was induced in SCID mice by intraperitoneal injection of 400 mg/kg acetaminophen."	3.74	Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. ( Kasai, N; Kiyono, T; Matsumoto, S; Matsushita, M; Takahashi, T; Todo, S; Tsuruga, Y, 2008)
" Adult Sprague-Dawley rats treated with acetaminophen or D-galactosamine (GalN) showed dose- and time-dependent histomorphological changes and TUNEL staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h."	3.74	Cytochrome c: a non-invasive biomarker of drug-induced liver injury. ( Adeyemo, O; Hanig, JP; Knapton, A; Miller, TJ; Noory, L; Weaver, J, 2008)
"Children frequently suffer infections accompanied by fever, which is commonly treated with acetaminophen (paracetamol), a use not devoid of risk."	3.73	The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study. ( Derasse, M; Klein, P; Weiser, M, 2005)
"The possible interference of acetaminophen, combined with antibiotics, in the treatment of acute otitis media (AOM) caused by a penicillin-resistant (minimal inhibitory concentration [MIC], 2 microg/mL), amoxicillin/clavulanic acid- and erythromycin-sensitive pneumococcus was evaluated in a gerbil model."	3.72	Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. ( Aguilar, L; Carcas, A; Cenjor, C; Garcia-Olmos, M; Gimenez, MJ; Parra, A; Ponte, C; Soriano, F, 2003)
"A case of acute generalized exanthematous pustulosis (AGEP) provoked by a patch test with acetaminophen is described."	3.72	A systemic reaction to patch testing for the evaluation of acute generalized exanthematous pustulosis. ( Brenner, S; Mashiah, J, 2003)
"The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure."	3.71	A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002)
"Drug-induced acute liver failure (ALF) is a devastating and often fatal disease mainly caused by poisoning by acetaminophen (APAP)."	3.71	Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse. ( Batteux, F; Calmus, Y; Ferret, PJ; Hammoud, R; Jaffray, P; Malassagne, B; Tran, A; Trébéden, H; Tulliez, M; Weill, B, 2001)
" To study this, we reviewed serum enzyme patterns early in the course of acute liver injury in patients with acute viral hepatitis A and B (n = 51), ischemic hepatitis (n = 20), and acetaminophen injury (n = 26)."	3.69	Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury. ( Cassidy, WM; Reynolds, TB, 1994)
"The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)."	3.69	Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996)
"This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose."	3.68	Acetaminophen induced pancreatitis. ( Caraccio, TR; Mofenson, HC; Nawaz, H; Steckler, G, 1991)
"Acute carbon tetrachloride poisoning in 19 patients was confirmed by means of laboratory analysis of blood specimens."	3.67	Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment. ( Flanagan, RJ; Mant, TG; Ruprah, M, 1985)
"We report a case of fulminant hepatic necrosis occurring in the setting of acetaminophen overdose and chronic alcohol use."	3.67	Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology. ( Baeg, NJ; Bodenheimer, HC; Burchard, K, 1988)
"A prospective study was undertaken to determine the cause of the acute anemia previously observed in pigs manifesting acute liver necrosis after administration of acetaminophen in dosages in excess of the LD100."	3.65	Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia. ( Fiskerstrand, C; Miller, DJ; Pichanick, GG; Saunders, SJ, 1977)
" There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis."	3.65	Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973)
"Acute abdominal pain is a frequent complaint in children attending emergency departments."	2.90	Administering analgesia sublingually is a suitable option for children with acute abdominal pain in the emergency department. ( Barbi, E; Cernich, M; Chiaretti, A; Conversano, E; Cozzi, G; D'Anna, C; Fantacci, C; Ronfani, L; Tipo, V; Zanchi, C; Zanon, D, 2019)
"Pain treatment with acetaminophen was not inferior to that with diclofenac or the combination of acetaminophen and diclofenac in acute minor musculoskeletal extremity trauma, both in rest and with movement."	2.87	Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial. ( Goddijn, H; Goslings, JC; Hollmann, MW; Kemper, EM; Lirk, P; Ridderikhof, ML; Schinkel, E; Van Dieren, S; Vandewalle, E, 2018)
"Migraine is a common form of headache that is a major burden for patients who often seek emergency care."	2.79	Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. ( Akdag, Ö; Eken, C; Elicabuk, H; Kiray, C; Serinken, M; Turkcuer, I; Uyan, E; Yilmaz, A, 2014)
"Mechanical neck pain is a common condition that affects an estimated 70% of persons at some point in their lives."	2.77	Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain: a randomized trial. ( Anderson, AV; Bracha, Y; Bronfort, G; Evans, R; Grimm, RH; Svendsen, KH, 2012)
"Ketamine has been shown to have a morphine-sparing effect soon after surgery."	2.74	The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. ( Baud, A; Couvret, C; Favard, L; Fusciardi, J; Laffon, M; Le Tendre, C; Pourrat, X; Remérand, F, 2009)
"Acetaminophen has been studied for acute migraine treatment."	2.73	Efficacy and tolerability of coadministration of rizatriptan and acetaminophen vs rizatriptan or acetaminophen alone for acute migraine treatment. ( Diamond, M; Diamond, S; Freitag, F; Janssen, I; Rodgers, A; Skobieranda, F, 2008)
"Low back pain is a highly common problem and causes much morbidity and socioeconomic loss in the community."	2.73	Caudal epidural injection versus non-steroidal anti-inflammatory drugs in the treatment of low back pain accompanied with radicular pain. ( Cakar, E; Dincer, U; Dursan, H; Kiralp, MZ; Yasar, E, 2007)
"Rofecoxib was associated with a significantly lower incidence of nausea (18."	2.71	Comparison of rofecoxib and oxycodone plus acetaminophen in the treatment of acute pain: a randomized, double-blind, placebo-controlled study in patients with moderate to severe postoperative pain in the third molar extraction model. ( Fricke, JR; Korn, S; Kotey, PN; Vassil, TC, 2004)
"In the acute migraine attack patients were treated intravenously with either 1000mg paracetamol (acetaminophen) or placebo."	2.71	Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study. ( Evers, S; Jürgens, T; Kaempfe, N; Kraemer, C; Leinisch, E; May, A; Sostak, P; Straube, A, 2005)
"Rofecoxib was statistically significantly superior to codeine/acetaminophen with respect to TOPAR4, patient global assessment, peak pain relief, and duration of analgesic effect."	2.71	Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. ( Bird, SR; Bohidar, NR; Chang, DJ; King, T, 2005)
"Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity."	2.70	Stroke severity determines body temperature in acute stroke. ( Boysen, G; Christensen, H, 2001)
"The acetaminophen group had lower pain scores on Day 1 (2."	2.69	Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. ( Fox, L; McGuinnety, M; Schug, SA; Sidebotham, DA; Thomas, J, 1998)
"In conclusion, alloPBSCT in ANLL is associated with a faster engraftment, no greater incidence of AGVHD, but increased risk of CGVHD."	2.69	Allogeneic peripheral blood stem cell transplantation in acute non-lymphoblastic leukemia. ( Akan, H; Arat, M; Arslan, O; Beksaç, M; Celebi, H; Gürman, G; Ilhan, O; Koç, H; Konuk, N; Ozcan, M; Ustün, C; Uysal, A, 1998)
"Nimesulide was metabolised to its principal hydroxy metabolite, which was detectable in samples obtained 0."	2.67	Clinical and pharmacokinetic study of nimesulide in children. ( Berardi, M; Guarnaccia, S; Renzetti, I; Ugazio, AG, 1993)
"Forty-six patients with acute migraine attacks were treated with intramuscular injection of 75 mg diclofenac sodium, and another group of forty patients with intramuscular injection of paracetamol."	2.67	Treatment of acute migraine attack with diclofenac sodium: a double-blind study. ( Chrisikos, N; Fotiadou, A; Karabetsos, A; Karachalios, GN; Kehagioglou, K, 1992)
"Tiaprofenic acid (Surgam) is a non steroidal anti-inflammatory drug used for acute inflammation during episode of upper respiratory tract infection in adults."	2.67	[Efficacy and tolerability of tiaprofenic acid (Surgam) in acute sinusitis in adults. Results of a randomized study versus paracetamol and placebo]. ( Frachet, B; Genes, N; Rezvani, Y, 1991)
"232 children aged 3-10 years with acute earache and at least one abnormal eardrum (114 allocated to receive antibiotic, 118 placebo)."	2.67	Acute red ear in children: controlled trial of non-antibiotic treatment in general practice. ( Bain, J; Burke, P; Dunleavey, J; Robinson, D, 1991)
"Acute soft tissue injuries are common and costly."	2.66	Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. ( Dalziel, SR; Jones, P; Lamdin, R, 2020)
"Ibuprofen 400 mg was more effective than acetaminophen 1000 mg for Sum Pain Intensity Difference (SPID), Total Pain Relief (TOTPAR), sum pain half-gone, and overall evaluation (P less than ."	2.66	Ibuprofen and acetaminophen in the relief of acute pain: a randomized, double-blind, placebo-controlled study. ( Cohn, P; Cooper, SA; Gelb, S; Goldman, E; Schachtel, BP, 1989)
"Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine."	2.66	Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986)
"The relief of acute migraine attacks with an analgesic/antihistamine combination containing paracetamol, codeine phosphate, doxylamine succinate and caffeine (Mersyndol) compared with that achieved with a placebo has been studied in a double-blind, crossover trial."	2.64	Treatment of migraine attacks with an analgesic combination (Mersyndol). ( Somerville, BW, 1976)
"Fever is a very common adaptive immune response in acute respiratory tract disorders during infancy."	2.61	Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections. ( Brandes-Schramm, J; Kamin, W; Lehmacher, W; Seifert, G; Zimmermann, A, 2019)
" There is concern that current NAC dosing is not large enough to adequately treat large APAP ingestions."	2.61	Evaluation and treatment of acetaminophen toxicity. ( Curry, SC; Fisher, ES, 2019)
" The evidence was usually either low quality or very low quality, reflecting study limitations, indirectness such from as suboptimal dosing of single comparators, imprecision, or one or more of these."	2.52	Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. ( Dalziel, SR; Frampton, C; Jones, P; Lamdin, R; Miles-Chan, JL, 2015)
"Migraine is a common, disabling condition and a burden for the individual, health services and society."	2.49	Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA, 2013)
"Appropriate treatment of pain requires an understanding of the characteristics of pain, including the severity and the nature of the pain-for example, acute versus chronic pain or nociceptive versus neuropathic pain."	2.49	An overview of pain management: the clinical efficacy and value of treatment. ( Nalamachu, S, 2013)
"Acetaminophen is a leading cause of overdose-related hepatotoxicity."	2.47	Intravenous acetylcysteine for the treatment of acetaminophen overdose. ( Doyon, S; Klein-Schwartz, W, 2011)
" The average lengths of treatment and stay for IV dosing were 23."	2.47	Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. ( Blackford, MG; Felter, T; Gothard, MD; Reed, MD, 2011)
"The severity of poisoning is assessed by gathering all information about the patient, the drug(s) ingested, the circumstances of ingestion, and any other substances ingested at the same time."	2.46	Acute poisoning following ingestion of medicines: initial management. How to treat life-threatening complications and to evaluate the risk of delayed effects and psychological distress. ( , 2010)
"In this systematic review we present information relating to the benefits and harms of the following interventions: differences in efficacy among different oral NSAIDs, between oral and topical NSAIDs, and between oral NSAIDs and alternative analgesics; dose-response relationship of oral NSAIDs; and H(2) blockers, misoprostol, or proton pump inhibitors to mitigate gastrointestinal adverse effects of oral NSAIDs."	2.46	NSAIDs. ( Gøtzsche, PC, 2010)
"This case was diagnosed as eosinophilic pneumonia caused by several drugs, and to our knowledge, this is the first report in Japan of ibuprofen (EVE-A tablet)-induced pneumonia."	2.45	[Acute eosinophilic pneumonia caused by several drugs including ibuprofen]. ( Anan, E; Hiramatsu, K; Hirata, N; Ishii, H; Kadota, J; Kai, N; Kishi, K; Nakama, K; Shirai, R; Tokimatsu, I, 2009)
"In this systematic review we present information relating to the benefits and harms of the following interventions: alternative analgesics, H(2) blockers, misoprostol, NSAIDs (systemic, topical, differences in efficacy between, dose-response relationship of), proton pump inhibitors."	2.44	NSAIDs. ( Gøtzsche, PC, 2007)
"In the acute migraine attack, a single dose of either ibuprofen 10 mg/kg or paracetamol 15 mg/kg has been shown to be effective, with only a few adverse effects."	2.43	[Pharmacologic treatment of acute migraine attack in children]. ( Auvin, S; Cuvellier, JC; Joriot, S; Vallée, L, 2005)
"Acetaminophen poisoning accounts for a disproportionate percentage of all toxic ingestions, and can be life-threatening."	2.43	An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. ( Marzullo, L, 2005)
"Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events."	2.43	Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005)
"Pain is a common reason to attend hospital but it is often inadequately managed."	2.42	Pharmacological techniques for managing acute pain in emergency departments. ( Butcher, D, 2004)
"Codeine is an opiate with uncertain and unpredictable effects."	2.42	[Problem forte--is paracetamol-codeine combination rational?]. ( Helland, A; Slørdal, L; Spigset, O, 2004)
"This could be shown for dental but not postsurgical pain, because more patients were available for the former."	2.41	Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. ( Edwards, JE; McQuay, HJ; Moore, RA, 2002)
"Pain is the most common symptom of acute pancreatitis (AP), and opioids have been utilized as the cornerstone of treatment."	1.91	Analgesic Patterns and Opioid Administration in Children Hospitalized With Acute Pancreatitis. ( Abu-El-Haija, M; Gorbounova, I; Palermo, TM; Tham, SW, 2023)
"Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects."	1.56	The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. ( Chang, Y; Cheng, B; Gao, W; Gao, Y; Gao, Z; Liu, C; Miao, W; Song, C; Wei, L; Williams, K; Xu, Q; Yang, X; Yang, Z; Zhang, J; Zhang, Y, 2020)
"Among first-line methods to treat fever, ice packs were the most frequently utilized physical method (n=90, [47%]), external nonautomated system was the most frequent utilized device (n=49, [25%]), and paracetamol was the most frequently utilized drug (n=135, [70%])."	1.51	A Survey on Fever Monitoring and Management in Patients With Acute Brain Injury: The SUMMA Study. ( Helbok, R; Oddo, M; Picetti, E; Prisco, L; Taccone, FS, 2019)
" Plasma samples were collected at 17 hr after dosing (during the manifestation of symptoms) and at one month (after recovery) and were subjected to LC-MS analysis of NAPQI-adducts."	1.51	LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash. ( Kubo, T; Lee, SH; Oe, T; Ozawa, M, 2019)
"Five patients had recurrences and were treated as outpatients without antibiotics."	1.42	Outpatient, non-antibiotic management in acute uncomplicated diverticulitis: a prospective study. ( Andreasson, K; Chabok, A; Isacson, D; Nikberg, M; Smedh, K; Thorisson, A, 2015)
"Paracetamol-induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children."	1.40	Glucose-6-phosphate dehydrogenase deficiency: an unusual cause of acute jaundice after paracetamol overdose. ( Phillpotts, S; Sen, S; Tash, E, 2014)
"Acetaminophen (APAP) hepatotoxicity results from cytochrome P450 metabolism of APAP to the toxic metabolite, n-acetyl-benzoquinone imine (NAPQI), which reacts with cysteinyl residues to form APAP adducts and initiates cell injury."	1.36	Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. ( Getachew, Y; James, L; Lee, WM; Miller, BC; Thiele, DL, 2010)
" Furthermore, the use of antidotes that reduced the toxic insult was also recorded using this technique."	1.35	Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. ( Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A, 2009)
"In contrast, symptoms and hypoxemia reappeared when minocycline was re-administered."	1.34	Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test. ( Ando, M; Kumamoto, T; Matsuno, O; Miyazaki, E; Nureki, S; Okubo, T; Ono, E, 2007)
"Although acute pain is frequently reported by patients admitted to the emergency room, it is often insufficiently evaluated by physicians and is thus undertreated."	1.34	Acute pain in adults admitted to the emergency room: development and implementation of abbreviated guidelines. ( Blanc, C; Buclin, T; Decosterd, I; Givel, JC; Hugli, O; Mouhsine, E; Tamchès, E; Yersin, B, 2007)
"55% of poisonings were intentional, where paracetamol and benzodiazepines were the preferred agents."	1.34	[A study of 355 consecutive acute poisoning cases admitted to an emergency ward at Copenhagen University Hospital, Bispebjerg in 2001]. ( Angelo, HR; Christensen, HR; Gude, AB; Hoegberg, LC; Nielsen, J; Pedersen, M, 2007)
"L-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the beta-oxidation of fatty acid in the mitochondria."	1.34	Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. ( Atakisi, O; Citil, M; Erginsoy, S; Karapehlivan, M; Kart, A; Tunca, R; Yapar, K, 2007)
" The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID."	1.33	Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. ( Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2006)
"The sequence and timing of taking migraine medications, whether prescription or over-the-counter, and the patient's response to their treatment, is unknown."	1.33	Acute migraine treatment: patterns of use and satisfaction in a clinical population. ( Hopkins, M; Malik, SN; Silberstein, SD; Young, WB, 2006)
"Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI)."	1.33	Role of acetaminophen in acute myocardial infarction. ( Gorman, JH; Gorman, RC; Hinmon, R; Jackson, BM; Leshnower, BG; Parish, LM; Plappert, T; Sakamoto, H; Zeeshan, A, 2006)
" The daily dose did not exceed the therapeutic dosage and the mean was 1."	1.33	Influence of acetaminophen at therapeutic doses on surrogate markers of severity of acute viral hepatitis. ( Boujaoude, J; Honein, K; Moucari, R; Sayegh, R; Slim, R; Yaghi, C, 2006)
"Paracetamol is regarded as a relatively safe drug in the gastro-duodenal region of humans but recent epidemiological investigations have suggested that at high doses there may be an increased risk of ulcers and bleeding."	1.33	Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation. ( Rainsford, KD; Whitehouse, MW, 2006)
"Hyperamylasaemia and even acute pancreatitis have been reported in patients with paracetamol poisoning."	1.32	Hyperamylasaemia and acute pancreatitis in paracetamol poisoning. ( Dalhoff, K; Schmidt, LE, 2004)
" A combination of opioids, NSAIDs and paracetamol in order to relieve pain allows both for a significant reduction in the dosage of respective drugs, fewer side effects and an improved pain relief."	1.31	[Pharmacotherapy of postoperative pain]. ( Cieniawa, T; Dobrogowski, J; Przeklasa-Muszyńska, A; Wordliczek, J, 2000)
" The dose-response curves were first obtained for each drug alone."	1.30	Isobolographic analysis of interactions between intravenous morphine, propacetamol, and diclofenac in carrageenin-injected rats. ( Benoist, JM; Fletcher, D; Gautron, M; Guilbaud, G, 1997)
"Probenecid pretreatment promoted an elevation in the urinary 16-hr excretion of APAP and a diminution in the plasma levels attained by APAP."	1.30	Probenecid protects against In vivo acetaminophen-induced nephrotoxicity in male Wistar rats. ( Elías, MM; Monasterolo, LA; Trumper, L, 1998)
"We assessed the quality of assessment and reporting of adverse effects in randomized, double-blind clinical trials of single-dose acetaminophen or ibuprofen compared with placebo in moderate to severe postoperative pain."	1.30	Reporting of adverse effects in clinical trials should be improved: lessons from acute postoperative pain. ( Collins, SL; Edwards, JE; McQuay, HJ; Moore, RA, 1999)
"Sixty-nine children with first febrile seizures and no history of previous unprovoked seizures were matched for age (+/- 6 months), site of routine pediatric care, and date of visit (+/- 2 weeks) with 1 or 2 febrile controls who had no history of previous febrile or unprovoked seizures."	1.29	Risk factors for a first febrile seizure: a matched case-control study. ( Berg, AT; Crain, EF; Hauser, WA; Salomon, ME; Shapiro, ED; Shinnar, S, 1995)
" A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found."	1.27	[Paracetamol poisoning in a swine model]. ( Artwohl, J; Dziwisch, L; Henne-Bruns, D; Kremer, B, 1988)
" A close correlation between administered dosage of the drug, acetaminophen blood levels, and methemoglobinemia was found."	1.27	Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models. ( Artwohl, J; Broelsch, C; Henne-Bruns, D; Kremer, B, 1988)
" In 87% of the cases receiving aspirin, their maximum daily dosage did not exceed recommended levels, but their doses were higher than those of controls receiving aspirin."	1.26	Reye's syndrome and medication use. ( Campbell, RJ; Correa-Villaseñor, A; Hall, LJ; Halpin, TJ; Holtzhauer, FJ; Hurwitz, ES; Lanese, R; Rice, J, 1982)
"In an acute migraine clinic, patients were all treated with metoclopramide 10 mg i."	1.26	Paracetamol (acetaminophen) versus acetylsalicylic acid in migraine. ( Olesen, J; Tfelt-Hansen, P, 1980)

Research

Studies (388)

Authors

Clinical Trials (36)

Trial Overview

Trial Outcomes

Change From Baseline at Day 3 in Pain Visual Analog Scale (VAS) - Per Protocol Population

Timeframe	Studies, this research(%)	All Research%
pre-1990	74 (19.07)	18.7374
1990's	69 (17.78)	18.2507
2000's	142 (36.60)	29.6817
2010's	94 (24.23)	24.3611
2020's	9 (2.32)	2.80

Authors	Studies
Perrin, G	1
Arnoux, A	1
Berdot, S	1
Katsahian, S	1
Danchin, N	1
Sabatier, B	1
Kara, A	1
Büyükcam, A	1
Sütçü, M	1
Sali, E	1
Bozdemir, ŞE	1
Kara, M	1
İlarslan, EÇ	1
Kaya, C	1
Karakaşlılar, S	1
Sönmez, G	1
Kara, SS	1
Bedir, T	1
Albayrak, E	1
Kara, TT	1
Çelebi, S	1
Öz, FN	1
Karbuz, A	1
Somer, A	1
Alabaz, D	1
Tezer, H	1
Özdemir, H	1
Çiftçi, E	1
Yano, K	1
Muto, M	1
Nagai, T	1
Harumatsu, T	1
Kedoin, C	1
Nagano, A	1
Matsui, M	1
Murakami, M	1
Sugita, K	1
Onishi, S	1
Yamada, K	1
Yamada, W	1
Matsukubo, M	1
Kaji, T	1
Ieiri, S	1
Gorbounova, I	1
Tham, SW	1
Abu-El-Haija, M	1
Palermo, TM	1
Qureshi, I	1
Abdulrashid, K	1
Thomas, SH	1
Abdel-Rahman, ME	1
Pathan, SA	1
Harris, T	1
Margan Koletic, Z	1
Dosenovic, S	1
Puljak, L	2
Abo El-Magd, NF	1
Eraky, SM	1
Gao, Z	1
Zhang, J	1
Wei, L	1
Yang, X	1
Zhang, Y	1
Cheng, B	1
Yang, Z	1
Gao, W	1
Song, C	1
Miao, W	1
Williams, K	1
Liu, C	1
Xu, Q	1
Chang, Y	1
Gao, Y	1
Jones, P	2
Lamdin, R	2
Dalziel, SR	2
Pannala, VR	1
Estes, SK	1
Rahim, M	1
Trenary, I	1
O'Brien, TP	1
Shiota, C	1
Printz, RL	1
Reifman, J	1
Shiota, M	1
Young, JD	1
Wallqvist, A	1
Ocan, M	1
Aono, M	1
Bukirwa, C	1
Luyinda, E	1
Ochwo, C	1
Nsambu, E	1
Namugonza, S	1
Makoba, J	1
Kandaruku, E	1
Muyende, H	1
Nakawunde, A	1
Ridderikhof, ML	1
Lirk, P	1
Goddijn, H	1
Vandewalle, E	1
Schinkel, E	1
Van Dieren, S	1
Kemper, EM	1
Hollmann, MW	1
Goslings, JC	1
Jeric, M	1
Surjan, N	1
Jelicic Kadic, A	1
Riva, N	1
Muñoz Romo, R	1
M Borobia Pérez, A	1
A Muñoz, M	1
Carballo Cardona, C	1
Cobo Mora, J	1
Carcas Sansuán, AJ	1
Ackerman, Z	1
Skarzinski, G	1
Link, G	1
Glazer, M	1
Pappo, O	1
Grozovski, M	1
Kakorin, PA	1
Babenkova, IV	1
Teselkin, YO	1
Ramenskaya, GV	1
Demura, TA	1
Kukes, VG	1
Cozzi, G	1
Zanchi, C	1
Chiaretti, A	1
Tipo, V	1
Cernich, M	1
D'Anna, C	1
Fantacci, C	1
Conversano, E	1
Zanon, D	1
Ronfani, L	1
Barbi, E	1
Picetti, E	1
Oddo, M	1
Prisco, L	1
Helbok, R	1
Taccone, FS	1
Dong, S	1
Ji, J	1
Zhang, B	1
Hu, L	1
Cui, X	1
Wang, H	2
Sharawat, IK	1
Suthar, R	1
Seifert, G	1
Brandes-Schramm, J	1
Zimmermann, A	1
Lehmacher, W	1
Kamin, W	1
Fisher, ES	1
Curry, SC	1
Ozawa, M	1
Kubo, T	1
Lee, SH	1
Oe, T	1
Eken, C	3
Serinken, M	4
Elicabuk, H	2
Uyanik, E	1
Erdal, M	1
Chou, D	2
Abalos, E	2
Gyte, GM	2
Gülmezoglu, AM	2
Hugenholtz, GC	1
Meijers, JC	1
Adelmeijer, J	1
Porte, RJ	1
Lisman, T	1
Derry, S	2
Moore, RA	5
Delgado, M	1
Garrido, F	1
Pérez-Miguelsanz, J	1
Pacheco, M	1
Partearroyo, T	1
Pérez-Sala, D	1
Pajares, MA	1
Zare, MA	1
Ghalyaie, AH	1
Fathi, M	1
Farsi, D	1
Abbasi, S	1
Hafezimoghadam, P	1
Turkcuer, I	1
Yilmaz, A	1
Akdag, Ö	1
Uyan, E	1
Kiray, C	1
Gupta, S	1
Oosthuizen, R	1
Pulfrey, S	1
Nalamachu, S	1
Cavanaugh, Z	1
Naut, ER	1
Phillpotts, S	1
Tash, E	1
Sen, S	1
Zigmond, E	1
Samia-Grinberg, S	1
Pasmanik-Chor, M	1
Brazowski, E	1
Shibolet, O	1
Halpern, Z	1
Varol, C	1
Maitra, S	1
Baidya, DK	1
Khanna, P	1
Ray, BR	1
Panda, SS	1
Bajpai, M	1
Zhang, A	1
Jiang, T	1
Luo, Y	1
Zheng, Z	1
Shi, X	1
Xiao, Z	1
Fang, Y	1
Feng, D	1
Wang, Y	1
Weng, H	1
Kong, X	1
Martin-Murphy, BV	1
Li, Y	1
Park, O	1
Dooley, S	1
Ju, C	1
Gao, B	1
Maeda, H	1
Hirata, K	1
Watanabe, H	2
Ishima, Y	1
Chuang, VT	1
Taguchi, K	1
Inatsu, A	1
Kinoshita, M	1
Tanaka, M	1
Sasaki, Y	1
Otagiri, M	1
Maruyama, T	1
Camilleri, R	1
Isacson, D	1
Thorisson, A	1
Andreasson, K	1
Nikberg, M	1
Smedh, K	1
Chabok, A	1
Miles-Chan, JL	1
Frampton, C	1
Friedman, BW	1
Dym, AA	1
Davitt, M	1
Holden, L	1
Solorzano, C	1
Esses, D	1
Bijur, PE	1
Gallagher, EJ	1
Ishii, I	1
Kamata, S	1
Hagiya, Y	1
Abiko, Y	1
Kasahara, T	1
Kumagai, Y	1
Katselis, C	1
Apostolou, K	1
Feretis, T	1
Papanikolaou, IG	1
Zografos, GC	1
Toutouzas, K	1
Papalois, A	2
Sánchez-Velázquez, P	1
Grande, L	1
Pera, M	1
Gülen, B	2
Dur, A	2
Karcıoğlu, Ö	2
Sönmez, E	1
Mali, JP	1
Mentula, PJ	1
Leppäniemi, AK	1
Sallinen, VJ	1
Tong, HY	1
Medrano, N	1
Borobia, AM	1
Ruiz, JA	1
Martínez, AM	1
Martín, J	1
Quintana, M	1
García, S	1
Carcas, AJ	1
Ramírez, E	1
Moya, P	2
Bellon, M	1
Arroyo, A	2
Galindo, I	1
Candela, F	2
Lacueva, J	1
Calpena, R	2
Young, SE	1
Bothwell, JD	1
Walsh, RM	1
Calvano, J	1
Edwards, G	1
Hixson, C	1
Burr, H	1
Mangipudy, R	1
Tirmenstein, M	1
Gottlieb, M	1
Njie, A	1
Sjoukes, A	1
Venekamp, RP	1
van de Pol, AC	1
Hay, AD	1
Little, P	2
Schilder, AG	1
Damoiseaux, RA	1
Kocyigit, A	1
Kilic, E	1
Helbling, R	1
Conficconi, E	1
Wyttenbach, M	1
Benetti, C	1
Simonetti, GD	1
Bianchetti, MG	1
Hamitaga, F	1
Lava, SA	1
Fossali, EF	1
Milani, GP	1
Freitag, F	1
Diamond, M	1
Diamond, S	1
Janssen, I	1
Rodgers, A	1
Skobieranda, F	1
Mattia, C	1
Coluzzi, F	1
Sarzi Puttini, P	1
Viganó, R	1
Senarathna, SM	1
Ranganathan, SS	1
Dawson, AH	1
Buckley, N	1
Fernandopulle, BM	1
Doyon, S	2
Klein-Schwartz, W	2
Soylu, A	1
Dolapcioglu, C	1
Dolay, K	1
Ciltas, A	1
Yasar, N	1
Kalayci, M	1
Alis, H	1
Sever, N	1
Den Hertog, HM	2
van der Worp, HB	6
Tseng, MC	1
Dippel, DW	6
Zira, A	1
Mikros, E	1
Giannioti, K	1
Galanopoulou, P	1
Liapi, C	1
Theocharis, S	1
Caballero Vallés, PJ	1
Dorado Pombo, S	1
Díaz Brasero, A	1
García Gil, ME	1
Yubero Salgado, L	1
Torres Pacho, N	1
Ibero Esparza, C	1
Cantero Bengoechea, J	1
Kenealy, T	2
Gøtzsche, PC	2
Treudler, R	1
Grunewald, S	1
Gebhardt, C	1
Simon, JC	1
Anan, E	1
Shirai, R	1
Kai, N	1
Ishii, H	1
Hirata, N	1
Kishi, K	1
Tokimatsu, I	1
Nakama, K	1
Hiramatsu, K	1
Kadota, J	1
Gaskell, H	1
McQuay, HJ	4
Miner, JR	1
Marchetti, A	1
Rossiter, R	1
Hancock, MJ	3
Maher, CG	3
Latimer, J	3
McLachlan, AJ	3
Day, RO	3
Davies, RA	1
Remérand, F	1
Le Tendre, C	1
Baud, A	1
Couvret, C	1
Pourrat, X	1
Favard, L	1
Laffon, M	1
Fusciardi, J	1
Bach, SM	1
Holten, KB	1
Bertuola, F	1
Morando, C	1
Menniti-Ippolito, F	1
Da Cas, R	1
Capuano, A	1
Perilongo, G	1
Da Dalt, L	1
Shepherd, M	2
Aickin, R	1
Getachew, Y	1
James, L	1
Lee, WM	2
Thiele, DL	1
Miller, BC	1
Beer, GM	1
Goldscheider, E	1
Weber, A	1
Lehmann, K	1
Fredheim, OM	1
Nøstdahl, T	1
Nordstrand, B	1
Høivik, T	1
Rygnestad, T	2
Borchgrevink, PC	1
Clarke, H	1
Kay, J	1
Mitsakakis, N	1
Katz, J	1
Hirose, Y	2
Mathieu-Nolf, M	1
Mathieu, D	1
Williams, CM	1
Cooper, CW	2
McAuley, JH	2
Lin, CW	1
Mehlisch, DR	1
Aspley, S	1
Daniels, SE	1
Bandy, DP	1
Supornsilpchai, W	1
le Grand, SM	1
Srikiatkhachorn, A	1
Lawrence, DT	1
Bechtel, LK	1
Charlton, NP	1
Holstege, CP	1
Chandrasekaran, VR	2
Periasamy, S	1
Liu, LL	2
Liu, MY	2
Green, TJ	1
Sivilotti, ML	2
Langmann, C	1
Yarema, M	1
Juurlink, D	1
Burns, MJ	1
Johnson, DW	2
Thompson, HJ	1
Kagan, SH	1
Shaikh, N	1
Hoberman, A	1
Kurs-Lasky, M	1
Rockette, HE	1
Chandra, A	1
Colborn, DK	1
Hooper, EG	1
Reis, EC	1
Dahi-Taleghani, M	1
Mousavifard, S	1
Tahmoureszade, S	1
Dabbagh, A	1
Mak, WY	1
Yuen, V	1
Irwin, M	1
Hui, T	1
Witkop, M	1
Lambing, A	1
Kachalsky, E	1
Divine, G	1
Rushlow, D	1
Dinnen, J	1
Fruchter, LL	1
Alexopoulou, I	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-Blind, 7-Day Study of the Efficacy and Safety of Rofecoxib Versus Placebo and Diclofenac in Patients With Acute Painful Rotator Cuff Syndrome[NCT00140933]	Phase 3	274 participants	Interventional	2003-04-30	Terminated
Efficacy and Security of Combined Analgesia (Opioid and Anti-inflammatory Agent) to Control Pain in Children Seen in the Emergency Department for a Trauma of a Limb[NCT01189773]	Phase 4	200 participants (Actual)	Interventional	2008-02-29	Completed
An Open Label Randomized Multicenter Comparative Study On Celecoxib Efficacy And Safety Versus Non-Selective NSAID In Acute Pain Due To Ankle Sprain[NCT00446797]	Phase 4	278 participants (Actual)	Interventional	2007-05-31	Completed
Ibuprofen Versus Acetaminophen vs Their Combination in the Relief of Musculoskeletal Pain in the Emergency Setting[NCT01827475]	Phase 2	90 participants (Actual)	Interventional	2010-07-31	Completed
The Efficacy and Safety of Administration of the COX-2 Selective NSAID, Etoricoxib (120mg od. for 7 Days) Compared to Diclofenac (50 mg Tds. for 7 Days) and Placebo as Adjunct Treatment in the First 7 Days of Treatment of Acute Grade II Lateral Ankle Liga[NCT00954785]	Phase 4	0 participants (Actual)	Interventional	2009-11-30	Withdrawn (stopped due to The study was terminated by Merck USA. The company did not supply drugs for the study.)
Non - Opioid Treatments (Single Administration) for Pain During the Early Postpartum Period After Vaginal Delivery[NCT04653506]		1,000 participants (Anticipated)	Interventional	2020-11-28	Recruiting
A Single Blinded, Open-labelled, Randomized Control Trial Comparing Acetaminophen Rectal Suppository With Diclofenac Rectal Suppository as Analgesia for Perineal Injury Following Childbirth[NCT03041779]	Phase 2	909 participants (Actual)	Interventional	2015-10-31	Completed
A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872]	Phase 4	500 participants (Actual)	Interventional	2017-09-05	Terminated (stopped due to no longer recruiting or studying)
Study of Comparing Dexketoprofen to Placebo in Migraine Attack[NCT02159547]	Phase 4	224 participants (Actual)	Interventional	2014-05-31	Completed
The Comparison of the Effectiveness of Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack in Emergency Service[NCT01730326]	Phase 4	200 participants (Actual)	Interventional	2012-03-31	Completed
Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090]		134 participants (Actual)	Interventional	2018-04-16	Completed
Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial[NCT02619695]	Phase 4	160 participants (Anticipated)	Interventional	2015-06-30	Recruiting
"Interest of the Return to Primary Care of the Low Back Booklet of Health Insurance in the Recovery of Common Acute Low Back Pain"[NCT03953625]		33 participants (Actual)	Interventional	2018-11-29	Completed
A Randomized Three-armed Comparative Effectiveness Study of Various Medications for Musculoskeletal Low Back Pain: Defining the Added Benefit of Muscle Relaxants and Opioids.[NCT01587274]	Phase 4	323 participants (Actual)	Interventional	2012-04-30	Completed
Achieving Peri-Operative Pain Control Without Opioids[NCT04813991]	Phase 3	0 participants (Actual)	Interventional	2022-03-15	Withdrawn (stopped due to Enrollment was never initiated and the PI is leaving the institution so the study is closing.)
Aromatherapy for Management of Back Pain in the Emergency Department[NCT03377088]		60 participants (Anticipated)	Interventional	2017-12-11	Recruiting
Symptomatic Treatment of Acute Uncomplicated Diverticulitis[NCT02219698]		158 participants (Anticipated)	Interventional	2014-07-31	Completed
Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients[NCT02160301]	Phase 4	0 participants (Actual)	Interventional	2017-11-30	Withdrawn (stopped due to Insufficient infrastructure/funding for enrollment)
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283]	Phase 4	1,544 participants (Anticipated)	Interventional	2021-04-12	Enrolling by invitation
Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699]	Phase 4	41 participants (Actual)	Interventional	2013-09-30	Completed
Treatment of Acetaminophen Toxicity With Intravenous vs Oral N-acetylcysteine: A Retrospective Review[NCT00725179]		130 participants (Anticipated)	Observational	2008-08-31	Completed
Chiropractic Care, Medication, and Self-Care for Neck Pain[NCT00029770]	Phase 2	270 participants	Interventional	2001-09-30	Completed
A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597]	Phase 1/Phase 2	50 participants (Actual)	Interventional	2021-01-20	Completed
The Safety and Efficacy of 5% Lidocaine Patch and Flurbiprofen Patch for Relieving Acute Low Back Pain[NCT03171987]	Phase 4	120 participants (Anticipated)	Interventional	2017-06-14	Recruiting
A Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled Study to Evaluate the Efficacy of Rofecoxib and a Dosing Regimen of Oxycodone With Acetaminophen Over 24 Hours in Patients With Postoperative Dental Pain[NCT00092313]	Phase 3	271 participants (Actual)	Interventional	2002-06-30	Completed
A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440]		3,488 participants (Actual)	Observational	1998-01-31	Completed
Effectiveness of a Combined Acetaminophen and Ibuprofen Regimen for Management of Post-Tonsillectomy Pain in Pediatric Patients[NCT04551196]	Phase 3	47 participants (Actual)	Interventional	2020-09-28	Completed
A Phase III, Multicenter, Randomized Study to Assess the Efficacy and Safety of 0,5 mg Tizaspray® Administered Intranasally Versus Sirdalud® 2 mg Tablets, in Patients With Acute Low Back Pain[NCT02934061]	Phase 3	117 participants (Actual)	Interventional	2016-10-31	Completed
Tolerability, Safety and Activity of IDN5243, 4 mg Bid Intramuscularly in the Treatment of Low Back Pain. A Prospective, Open Label, Single-center, Uncontrolled Study[NCT02568826]	Phase 2	0 participants (Actual)	Interventional	2016-04-30	Withdrawn (stopped due to No patients enrolled in the study.)
Phase III Clinical Trial Studying Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children[NCT02477007]	Phase 3	304 participants (Actual)	Interventional	2015-12-03	Completed
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136]	Phase 4	84 participants (Actual)	Interventional	2011-01-31	Completed
Ibuprofen vs. Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?[NCT01605240]		50 participants (Anticipated)	Interventional	2012-07-31	Recruiting
Randomized Controlled Trial on the Effectiveness of Immediate Versus Delayed Access to Hospital-based Addiction Services[NCT01934751]		124 participants (Anticipated)	Interventional	2013-09-30	Recruiting
Comparison of the Effectiveness of 2 Manual Therapies on Functional Outcome in Sub-acute and Chronic Non-specific Low Back Pain at 3 Months : a Randomised Controlled Trial[NCT02034864]		400 participants (Actual)	Interventional	2014-02-17	Completed
Safety and Efficacy of Nonsteroidal Antiinflammatory Drug and Glucocorticoids in Acute Sciatica[NCT01816334]	Phase 4	50 participants (Actual)	Interventional	2013-01-31	Completed
Burden and Outcome of Shoulder Disorders in Primary Health Care[NCT01300091]		0 participants (Actual)	Observational		Withdrawn (stopped due to Recruitment not started)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Assessment of ankle pain by VAS: 100 mm horizontal line with left end being No Pain & right end being Worst Possible Pain. Participants drew vertical line on horizontal scale to best reflect current pain on full weight bearing of injured ankle. Distance from left end of line to mark. Change: mean score at day 3 minus mean score at baseline" (NCT00446797)
Timeframe: Baseline and day 3

Change From Baseline in Pain Visual Analog Scale (VAS) - Modified Intent to Treat Population

Intervention	scores on a scale (Mean)
Celecoxib	-44.88
nsNSAIDs	-40.76

"Assessment of ankle pain by VAS: 100 mm horizontal line, left end being No Pain & right end being Worst Possible Pain. Participants drew vertical line on horizontal scale to best reflect current pain on full weight bearing of injured ankle. Distance from left end of line to mark. Change: mean score at observation minus mean score at baseline" (NCT00446797)
Timeframe: Baseline and days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Index

Intervention	scores on a scale (Mean)
	Day 2	Day 3	Day 7
Celecoxib	-29.25	-44.87	-61.17
nsNSAIDs	-25.98	-40.75	-57.89

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~The pain interference index is the average of pain interference questions 5A to 5G. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5A

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	4.07	2.79	1.28
nsNSAIDs	4.01	2.83	1.33

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5A: Subject response to 'how, during the past 24 hours, pain has interfered with your general activity. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5B

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	5.40	3.65	1.78
nsNSAIDs	5.37	4.07	1.90

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5B: Subject response to 'how, during the past 24 hours, pain has interfered with your mood'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5C

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	3.72	2.43	1.17
nsNSAIDs	3.64	2.38	1.26

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5C: Subject response to 'how, during the past 24 hours, pain has interfered with your walking ability'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5D

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	5.10	3.58	1.65
nsNSAIDs	5.11	3.69	1.62

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5D: Subject response to 'how, during the past 24 hours, pain has interfered with your normal work (work outside the home and housework)'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5E

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	5.29	4.04	1.84
nsNSAIDs	5.39	4.04	1.87

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5E: Subject response to 'how, during the past 24 hours, pain has interfered with your relations with other people'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5F

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	2.70	1.81	0.80
nsNSAIDs	2.67	1.69	0.78

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5F: Subject response to 'how, during the past 24 hours, pain has interfered with your sleep'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5G

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	2.97	1.90	0.68
nsNSAIDs	2.87	1.86	0.82

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5G: Subject response to 'how, during the past 24 hours, pain has interfered with your enjoyment of life'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Index

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	3.33	2.13	1.07
nsNSAIDs	2.99	2.06	1.10

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Pain severity index is the average of the pain severity questions 1 to 4. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 1

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	4.24	2.84	1.37
nsNSAIDs	4.48	3.26	1.68

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q1: Subject response to 'describe your pain at its worst in the last 24 hours'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 1, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 2

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	5.71	3.81	2.08
nsNSAIDs	5.90	4.44	2.38

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q2: Subject response to 'describe your pain at its least in the last 24 hours'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 3

Intervention	scores on a scale (Mean)
	Day 2 (N = 133, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	3.25	2.07	0.83
nsNSAIDs	3.36	2.40	1.16

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q3: Subject response to 'describe your pain on the average'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 4

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N = 135, 131)	Day 7 (N = 133, 125)
Celecoxib	4.34	2.90	1.41
nsNSAIDs	4.41	3.26	1.74

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q4: Subject response to 'how much pain you have right now'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

Number of Subjects Responding (Improving) - MITT Population

Intervention	scores on a scale (Mean)
	Day 2 (N = 134, 133)	Day 3 (N =135, 131)	Day 7 (N = 133, 125)
Celecoxib	3.64	2.58	1.14
nsNSAIDs	4.23	2.92	1.43

The number of subjects showing a response: a decrease of at least 20 mm (that is improvement) on the pain visual analog scale (VAS) scale (NCT00446797)
Timeframe: Days 2, 3 and 7

Pain Relief - MITT Population

Intervention	participants (Number)
	Day 2 - response (N=134, 133)	Day 2 - no response	Day 3 - response (N=135, 131)	Day 3 - no response	Day 7 - response (N=133, 125)	Day 7 - no response
Celecoxib	91	43	124	11	129	4
nsNSAIDs	79	54	116	15	120	5

"Subject's response to the statement My relief from starting pain is. Scale from 0 = None to 4 = Complete." (NCT00446797)
Timeframe: Days 2, 3 and 7

Physician Global Assessment of Ankle Injury

Intervention	participants (Number)
	Day 2 - None (N=135, 132)	Day 2 - A little	Day 2 - Some	Day 2 - A lot	Day 2 -Complete	Day 3 - None (N=135, 131)	Day 3 - A little	Day 3 - Some	Day 3 - A lot	Day 3 -Complete	Day 7 - None (N=133, 125)	Day 7 - A little	Day 7 - Some	Day 7 - A lot	Day 7 -Complete
Celecoxib	8	25	49	52	1	0	15	33	84	3	1	6	7	77	42
nsNSAIDs	5	33	52	42	0	1	21	46	60	3	1	3	15	80	26

Investigator evaluation of overall severity of ankle injury. Scale: 5 point from 1 = Very mild (very mild signs and symptoms of ankle sprain) to 5 =Very severe (very severe signs and symptoms of ankle sprain) (NCT00446797)
Timeframe: Days 3 and 7

Subject Assessment of Normal Function / Activity

Intervention	participants (Number)
	Day 3 - very mild (N=134, 131)	Day 3 - mild	Day 3 - moderate	Day 3 - severe	Day 3 - very severe	Day 7 - very mild (N=132, 125)	Day 7 - mild	Day 7 - moderate	Day 7 - severe	Day 7 - very severe
Celecoxib	20	71	40	2	1	87	38	7	0	0
nsNSAIDs	12	79	38	2	0	70	47	7	1	0

"Subject response to question: How does your ankle injury affect your walking and normal activity? Scale from 1 = Normal walking/activity and no pain to 5 = Severely restricted walking due to pain and can't resume normal activities (normal activities defined as all activity that a subject did on a routine basis, including work and recreation)" (NCT00446797)
Timeframe: Days 2, 3 and 7

Subject's Global Assessment of Ankle Injury

Intervention	participants (Number)
	Day 2 - normal no pain (N =135, 133)	Day 2 - normal with pain	Day 2 - mildly restricted	Day 2 - moderately restricted	Day 2 - severely restricted	Day 3 - normal no pain (N = 135, 131)	Day 3 - normal with pain	Day 3 - mildly restricted	Day 3 - moderately restricted	Day 3 - severely restricted	Day 7 - normal no pain (N = 133, 125)	Day 7 - normal with pain	Day 7 - mildly restricted	Day 7 - moderately restricted	Day 7 - severely restricted
Celecoxib	5	40	59	19	12	18	52	49	14	2	62	55	11	4	1
nsNSAIDs	2	30	55	39	7	13	46	57	11	4	43	68	8	3	3

"Subject response to question: Considering all the ways your ankle injury affects you, how are you doing today? Scale: 5 point from 1 = very good (no symptoms and no limitation of normal activities) to 5 = very poor (very severe symptoms which are intolerable and inability to carry out all normal activities)." (NCT00446797)
Timeframe: Days 2, 3 and 7

Need for Rescue Pain Relief

Pain Severity

Intervention	participants (Number)
	Day 2 - Very good (no symptoms) (N=135, 133)	Day 2 - Good (mild symptoms)	Day 2 - Fair (moderate symptoms)	Day 2 - Poor (severe symptoms)	Day 2- Very poor (very severe symptoms)	Day 3 - Very good (no symptoms) (N=135, 131)	Day 3 - Good (mild symptoms)	Day 3 - Fair (moderate symptoms)	Day 3 - Poor (severe symptoms)	Day 3 - Very poor (very severe symptoms)	Day 7 - Very good (no symptoms) (N=133, 125)	Day 7 - Good (mild symptoms)	Day 7 - Fair (moderate symptoms)	Day 7 - Poor (severe symptoms)	Day 7 - Very poor (very severe symptoms)
Celecoxib	1	40	76	17	1	8	68	54	5	0	53	61	17	2	0
nsNSAIDs	1	31	80	19	2	6	55	63	7	0	37	63	21	4	0

Intervention	participants (Number)
Ibuprofen	11
Acetaminophen	10
Ibuprofen-acetaminophen Combination	5

Pain score on 100 mm VAS from 0 (no pain) to 100 (worst pain) (NCT01827475)
Timeframe: 1 hour

Adverse Effects

Intervention	mm (Mean)
Ibuprofen	39
Acetaminophen	43
Ibuprofen-acetaminophen Combination	42

The adverse effects is being recorded to the study form after the study drugs are administered at the 45th minutes. (NCT02159547)
Timeframe: 45th minutes

Visual Analogue Scale Change

Intervention	participants (Number)
Dexketoprofen	0
Normal Slaline	0

Change from baseline in Visual Analogue Scale, 100 mm, at 45th minutes. Visual Analogue Scale is measurement tool scoring tool between 0 (no pain) and 100 mm (worst pain). Minimum clinically significant change in pain score is 13 or 16 mm. (NCT02159547)
Timeframe: 45 minutes

Change in Functional Disability as Measured by the Roland Morris Disability Questionnaire

Intervention	units on a scale (Median)
Dexketoprofen	55
Normal Slaline	30

"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT01587274)
Timeframe: Baseline and one week after discharge from emergency department

2-hour Change Over Time Core Temperature

Intervention	units on a scale (Median)
Opioid	5
Skeletal Muscle Relaxant	4
Naproxen Alone	7

change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours

2-hour Change Over Time Heart Rate

Intervention	degrees Celsius (Mean)
Normal Saline Placebo	-0.01
Acetaminophen	-0.8

2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours

2-hour Change Over Time Systolic Blood Pressure

Intervention	BPM (Mean)
Normal Saline Placebo	2
Acetaminophen	-6

2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours

Core Body Temperature

Intervention	mm Hg (Mean)
Normal Saline Placebo	-0.1
Acetaminophen	-24

time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Heart Rate

Intervention	degrees Celsius (Mean)
Normal Saline Placebo	38.4
Acetaminophen	37.9

time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Respiratory Rate

Intervention	beats per minute (Mean)
Normal Saline Placebo	92
Acetaminophen	87

time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Systolic Blood Pressure

Intervention	breaths per minute (Mean)
Normal Saline Placebo	22
Acetaminophen	21

time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Opioid Consumption 12 Hours Post Operative

Intervention	mm Hg (Mean)
Normal Saline Placebo	143
Acetaminophen	127

Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours

Opioid Consumption Every 6 Hours Post Operative

Intervention	IV morphine mg equivalents (Mean)
Placebo	19.4
N-acetylcysteine (NAC)	15.6

Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours

Efficacy of Two Different Liquid Pain Medications: Tramadol vs. Codeine/Acetaminophen During the Post-tonsillectomy Recovery Period.

Intervention	IV morphine mg equivalents (Mean)
	6 hours	18 hours	24 hours	30 hours	36 hours	42	48
N-acetylcysteine (NAC)	12.0	19.9	24.7	27.2	29.7	33.1	34.9
Placebo	14.6	25.0	29.6	34.0	37.9	40.9	43.3

Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.

Number of Participants Reporting Side Effects During the Post-tonsillectomy Recovery Period.

Intervention	days (Median)
Capital® With Codeine Suspension	1.5
Tramadol Suspension	1

Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.

Article	Year
Comparison of intravenous paracetamol (acetaminophen) to intravenously or intramuscularly administered non-steroidal anti-inflammatory drugs (NSAIDs) or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic re Emergency medicine journal : EMJ, 2023, Volume: 40, Issue:7 Topics: Acetaminophen; Acute Disease; Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-S	2023
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl	2020
Treatment of acute migraine attacks in children with analgesics on the World Health Organization Essential Medicines List: A systematic review and GRADE evidence synthesis. Cephalalgia : an international journal of headache, 2018, Volume: 38, Issue:9 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Humans; Ibuprofen; Migraine Disorders	2018
Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections. BMC pediatrics, 2019, 04-23, Volume: 19, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Fever; Humans; Recovery of Function;	2019
Evaluation and treatment of acetaminophen toxicity. Advances in pharmacology (San Diego, Calif.), 2019, Volume: 85 Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Disease Progression;	2019
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain	2013
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain	2013
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain	2013
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain	2013
Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. The Cochrane database of systematic reviews, 2013, Apr-30, Issue:4 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combinatio	2013
An overview of pain management: the clinical efficacy and value of treatment. The American journal of managed care, 2013, Volume: 19, Issue:14 Suppl Topics: Acetaminophen; Acute Disease; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic P	2013
Acute perioperative pain in neonates: An evidence-based review of neurophysiology and management. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2014, Volume: 52, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesia; Analgesics, Opioid; Anesthesia, Epidural; Evidence-Based Me	2014
A meta-analysis of the reliability of the history in suspected poisoning. The Journal of emergency medicine, 2015, Volume: 48, Issue:6 Topics: Acetaminophen; Acute Disease; Cocaine; Drug Overdose; Humans; Medical History Taking; N-Methyl-3,4-m	2015
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. The Cochrane database of systematic reviews, 2015, Jul-01, Issue:7 Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Analgesics, Opioid; Anti-Inflammator	2015
Role of Stem Cells Transplantation in Tissue Regeneration After Acute or Chronic Acetaminophen Induced Liver Injury. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2016, Volume: 29, Issue:2 Topics: Acetaminophen; Acute Disease; Adipose Tissue; Antipyretics; Cell Differentiation; Chemical and Drug	2016
Outpatient treatment of uncomplicated diverticulitis: a systematic review. European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:6 Topics: Acetaminophen; Acute Disease; Ambulatory Care; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Diet	2016
Safely Managing Acute Osteoarthritis in the Emergency Department: An Evidence-Based Review. The Journal of emergency medicine, 2016, Volume: 51, Issue:6 Topics: Acetaminophen; Acute Disease; Administration, Cutaneous; Administration, Oral; Adrenal Cortex Hormon	2016
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. The Cochrane database of systematic reviews, 2016, 12-15, Volume: 12 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age	2016
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery". BioMed research international, 2017, Volume: 2017 Topics: Abdomen; Acetaminophen; Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Appendic	2017
Paracetamol/Tramadol association: the easy solution for mild-moderate pain. Minerva medica, 2008, Volume: 99, Issue:4 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Th	2008
Cooling therapy for acute stroke. The Cochrane database of systematic reviews, 2009, Jan-21, Issue:1 Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Humans; Hypothermia	2009
Sore throat. BMJ clinical evidence, 2007, Nov-20, Volume: 2007 Topics: Acetaminophen; Acute Disease; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Humans;	2007
NSAIDs. BMJ clinical evidence, 2007, Jun-01, Volume: 2007 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Dose	2007
[Acute eosinophilic pneumonia caused by several drugs including ibuprofen]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2009, Volume: 47, Issue:5 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Cephalosporins; Humans; Ibuprofen; Ly	2009
Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. The Cochrane database of systematic reviews, 2009, Jul-08, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Synergism; D	2009
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. The Cochrane database of systematic reviews, 2010, Mar-17, Issue:3 Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain	2010
[Treatment of acute pain during drug-assisted rehabilitation]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010, Apr-08, Volume: 130, Issue:7 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents	2010
Intravenous acetylcysteine for the treatment of acetaminophen overdose. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Antidotes; Chemical and Drug Ind	2011
Pharmacotherapy for acute pain in children: current practice and recent advances. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:6 Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents,	2011
Assessment of acute and persistent pain management in patients with haemophilia. Haemophilia : the official journal of the World Federation of Hemophilia, 2011, Volume: 17, Issue:4 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents,	2011
Acute poisoning following ingestion of medicines: initial management. How to treat life-threatening complications and to evaluate the risk of delayed effects and psychological distress. Prescrire international, 2010, Volume: 19, Issue:111 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Charcoal; Depression; Gastric Lavage; Humans; Poisonin	2010
Sore throat. BMJ clinical evidence, 2011, Jan-13, Volume: 2011 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Anti-Bacterial Agents;	2011
NSAIDs. BMJ clinical evidence, 2010, Jun-28, Volume: 2010 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Huma	2010
Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. Clinical therapeutics, 2011, Volume: 33, Issue:9 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Child; Clinical Trials as Topic;	2011
Use of the molecular adsorbent recirculating system (MARS™) for the management of acute poisoning with or without liver failure. Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:9 Topics: Acetaminophen; Acute Disease; Albumins; Amanita; Amphetamine; Calcium Channel Blockers; Cocaine; Hea	2011
Acute otitis media. Clinical evidence, 2002, Issue:7 Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Chewing Gum; Child, Preschool; Female; Humans;	2002
Acute otitis media. Clinical evidence, 2002, Issue:8 Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Chewing Gum; Child, Preschool; Female; Humans;	2002
Tramadol/paracetamol. Drugs, 2003, Volume: 63, Issue:11 Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Biological Availability; Chronic Dis	2003
Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain. European journal of anaesthesiology. Supplement, 2003, Volume: 28 Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Do	2003
New insights into haemostasis in liver failure. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003, Volume: 14 Suppl 1 Topics: Acetaminophen; Acute Disease; Antithrombins; Blood Coagulation Disorders; Blood Coagulation Factors;	2003
[Role of paracetamol in the acute pain management]. Drugs, 2003, Volume: 63 Spec No 2 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Clinical Trials as Topic; Humans; Pain	2003
Pharmacological techniques for managing acute pain in emergency departments. Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2004, Volume: 12, Issue:1 Topics: Acetaminophen; Acute Disease; Adult; Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Local; A	2004
Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Hepatitis, Viral, Human; Humans; Liver Failu	2004
[Problem forte--is paracetamol-codeine combination rational?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2004, Aug-26, Volume: 124, Issue:16 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Codeine	2004
Recent advances in postoperative pain therapy. British journal of anaesthesia, 2005, Volume: 95, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesia; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Human	2005
[Pharmacologic treatment of acute migraine attack in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2005, Volume: 12, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Intranasal; Administration, Oral; Adolescent; Age Fact	2005
Oral analgesics for acute nonspecific pain. American family physician, 2005, Mar-01, Volume: 71, Issue:5 Topics: Acetaminophen; Acute Disease; Administration, Oral; Algorithms; Analgesics, Non-Narcotic; Aspirin; H	2005
An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Current opinion in pediatrics, 2005, Volume: 17, Issue:2 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Chemic	2005
Acute poisoning: understanding 90% of cases in a nutshell. Postgraduate medical journal, 2005, Volume: 81, Issue:954 Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyc	2005
The placebo responder rate in children and adolescents. Headache, 2005, Volume: 45, Issue:3 Topics: Acetaminophen; Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Clinical T	2005
Valdecoxib for the management of chronic and acute pain. Expert review of neurotherapeutics, 2005, Volume: 5, Issue:1 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chr	2005
Acute otitis media in children. Clinical evidence, 2005, Issue:13 Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child;	2005
[Is there a risk to prescribe paracetamol at therapeutic doses in patients with acute or chronic liver disease?]. Gastroenterologie clinique et biologique, 2006, Volume: 30, Issue:5 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chro	2006
State of the art of paracetamol in acute pain therapy. Current opinion in anaesthesiology, 2006, Volume: 19, Issue:5 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Central Nervous System; Clinical Tr	2006
Use of medications in the treatment of acute low back pain. Clinics in occupational and environmental medicine, 2006, Volume: 5, Issue:3 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O	2006
Use of medications in the treatment of acute low back pain. Clinics in occupational and environmental medicine, 2006, Volume: 5, Issue:3 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O	2006
Use of medications in the treatment of acute low back pain. Clinics in occupational and environmental medicine, 2006, Volume: 5, Issue:3 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O	2006
Use of medications in the treatment of acute low back pain. Clinics in occupational and environmental medicine, 2006, Volume: 5, Issue:3 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O	2006
Otitis media in children (acute). Clinical evidence, 2006, Issue:15 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age	2006
A review of the literature on post-operative pain in older cancer patients. European journal of cancer (Oxford, England : 1990), 2007, Volume: 43, Issue:15 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Nefopam; Neoplas	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Annals of internal medicine, 2007, Oct-02, Volume: 147, Issue:7 Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid;	2007
Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicologic pathology, 2007, Volume: 35, Issue:6 Topics: Acetaminophen; Acute Disease; Animals; Cell Adhesion; Cell Movement; Hepatitis, Alcoholic; Humans; I	2007
Acute generalized exanthematous pustulosis induced by paracetamol. A case with severe hemodynamic disturbances. Dermatology (Basel, Switzerland), 1996, Volume: 193, Issue:4 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Diagnosis, Differential; Drug Eruptio	1996
Paracetamol with and without codeine in acute pain: a quantitative systematic review. Pain, 1997, Volume: 70, Issue:2-3 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, C	1997
Co-proxamol or paracetamol for acute pain? Drug and therapeutics bulletin, 1998, Volume: 36, Issue:10 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Dextropropoxyphene; Drug Combinations; Human	1998
[Severe hepatitis from therapeutic doses of paracetamol in an alcoholic patient]. Gastroenterologia y hepatologia, 1999, Volume: 22, Issue:5 Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced	1999
Single dose oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain. The Cochrane database of systematic reviews, 2000, Issue:4 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Therapy, Combinatio	2000
How effective are treatments other than antibiotics for acute sore throat? The British journal of general practice : the journal of the Royal College of General Practitioners, 2000, Volume: 50, Issue:459 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic;	2000
Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. Journal of pain and symptom management, 2002, Volume: 23, Issue:2 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Doub	2002
Acute acetaminophen overdose in adolescents and adults. Critical care nurse, 2000, Volume: 20, Issue:3 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Age Factors; Antidotes; Critical Ca	2000
Drug metabolism in liver disease. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H	1975
Acute liver injury. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati	1975
[Acute paracetamol poisoning]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1987, Jul-01, Volume: 40, Issue:13 Topics: Acetaminophen; Acute Disease; Humans	1987
Acute hepatic necrosis and fulminant hepatic failure. Gut, 1973, Volume: 14, Issue:10 Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise	1973

Article	Year
The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. International journal of pediatric otorhinolaryngology, 2022, Volume: 156 Topics: Acetaminophen; Acute Disease; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Earache; H	2022
Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial. Annals of emergency medicine, 2018, Volume: 71, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2018
Administering analgesia sublingually is a suitable option for children with acute abdominal pain in the emergency department. Acta paediatrica (Oslo, Norway : 1992), 2019, Volume: 108, Issue:1 Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Sublingual; Adolescent; Analgesics, No	2019
Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non	2014
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2014, Volume: 24, Issue:7 Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Analgesics,	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Intravenous paracetamol versus dexketoprofen in acute migraine attack in the emergency department: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2014
Efficacy of intravenous propacetamol hydrochloride in the treatment of an acute attack of migraine. European journal of internal medicine, 2014, Volume: 25, Issue:7 Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Female; Follow-Up	2014
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA, 2015, Oct-20, Volume: 314, Issue:15 Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen	2015
Pain treatment in patients with acute pancreatitis: A randomized controlled trial. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2016, Volume: 27, Issue:2 Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Intravenous; Adult; Aged; Analgesics,	2016
Symptomatic Treatment for Uncomplicated Acute Diverticulitis: A Prospective Cohort Study. Diseases of the colon and rectum, 2016, Volume: 59, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroida	2016
Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. CJEM, 2016, Volume: 18, Issue:6 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Amitriptyline; Dose-Response Relationship	2016
Oxidative Status and DNA Damage Following Analgesic Treatment in Patients with Acute Pancreatitis. Clinical laboratory, 2016, Jul-01, Volume: 62, Issue:7 Topics: Acetaminophen; Acute Disease; Analgesics; Antioxidants; DNA Damage; Female; Humans; Ketoprofen; Leuk	2016
Efficacy and tolerability of coadministration of rizatriptan and acetaminophen vs rizatriptan or acetaminophen alone for acute migraine treatment. Headache, 2008, Volume: 48, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Drug Thera	2008
Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent. World journal of gastroenterology, 2008, Nov-21, Volume: 14, Issue:43 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Do	2008
Randomized double-blind placebo controlled crossover study of acetaminophen, ibuprofen, acetaminophen/hydrocodone, and placebo for the relief of pain from a standard painful stimulus. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2009, Volume: 16, Issue:9 Topics: Acetaminophen; Acute Disease; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations	2009
Can predictors of response to NSAIDs be identified in patients with acute low back pain? The Clinical journal of pain, 2009, Volume: 25, Issue:8 Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida	2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesthesia and analgesia, 2009, Volume: 109, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana	2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesthesia and analgesia, 2009, Volume: 109, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana	2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesthesia and analgesia, 2009, Volume: 109, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana	2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesthesia and analgesia, 2009, Volume: 109, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana	2009
Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures. Emergency medicine Australasia : EMA, 2009, Volume: 21, Issue:6 Topics: Acetaminophen; Acute Disease; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analysis of Var	2009
Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later. Journal of anesthesia, 2010, Volume: 24, Issue:4 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Arthroplasty, Replacement, Hip; Celecoxib; Ch	2010
PACE--the first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial. BMC musculoskeletal disorders, 2010, Jul-23, Volume: 11 Topics: Acetaminophen; Activities of Daily Living; Acute Disease; Analgesia; Analgesics, Non-Narcotic; Clini	2010
Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: a randomized, double-blind, placebo-control Clinical therapeutics, 2010, Volume: 32, Issue:5 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents,	2010
Pain management in young children undergoing diagnostic tympanocentesis. Clinical pediatrics, 2011, Volume: 50, Issue:3 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Biopsy, Fine-Needle; Chi	2011
Rectal acetaminophen versus peritonsillar infiltration of bupivacaine for postoperative analgesia after adenotonsillectomy in children. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2011, Volume: 268, Issue:4 Topics: Acetaminophen; Acute Disease; Administration, Rectal; Adolescent; Analgesics, Non-Narcotic; Anesthes	2011
A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. Italian journal of pediatrics, 2011, Sep-29, Volume: 37 Topics: Acetaminophen; Acute Disease; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Anti-	2011
Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology (Baltimore, Md.), 2011, Volume: 54, Issue:5 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcoti	2011
Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain: a randomized trial. Annals of internal medicine, 2012, Jan-03, Volume: 156, Issue:1 Pt 1 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory A	2012
Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. BMC cardiovascular disorders, 2003, Feb-06, Volume: 3 Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida	2003
Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain. European journal of anaesthesiology. Supplement, 2003, Volume: 28 Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Do	2003
A 20-hour treatment for acute acetaminophen overdose. The New England journal of medicine, 2003, Jun-12, Volume: 348, Issue:24 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Drug Administ	2003
Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke. Neurology, 2003, Sep-09, Volume: 61, Issue:5 Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; H	2003
[Treatment of stroke by reducing the body temperature; 'Paracetamol (acetaminophen) in stroke' (PAIS): start of a clinical trial]. Nederlands tijdschrift voor geneeskunde, 2003, Oct-04, Volume: 147, Issue:40 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Double-Blind Method; Fever	2003
Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 17, Issue:2-3 Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida	2004
Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. Current medical research and opinion, 2004, Volume: 20, Issue:6 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics; Dose-Response Relationship, Drug; Doubl	2004
Comparison of rofecoxib and oxycodone plus acetaminophen in the treatment of acute pain: a randomized, double-blind, placebo-controlled study in patients with moderate to severe postoperative pain in the third molar extraction model. Clinical therapeutics, 2004, Volume: 26, Issue:5 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Doubl	2004
The analgesic efficacy of etoricoxib compared with oxycodone/acetaminophen in an acute postoperative pain model: a randomized, double-blind clinical trial. Anesthesia and analgesia, 2004, Volume: 99, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Double-Blind Method; Drug Therapy, Combination; Etoricoxib; Fem	2004
Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2004, Volume: 11, Issue:12 Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Bli	2004
The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain. Current medical research and opinion, 2005, Volume: 21, Issue:1 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varia	2005
Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:6 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anal	2005
Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study. Pain, 2005, Volume: 117, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Demogr	2005
Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st Clinical therapeutics, 2005, Volume: 27, Issue:7 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspi	2005
Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2005, Volume: 100, Issue:4 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analy	2005
Erythromycin promotes gastric emptying during acute pain in volunteers. Anesthesia and analgesia, 2006, Volume: 102, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Breath Tests; Caprylates; Cold Temperature; Cross-Over Studies;	2006
Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. Clinical therapeutics, 2006, Volume: 28, Issue:9 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesia; Analgesics, Non-Narcotic; Doub	2006
[The use of "Antigrippin-maximum" in the complex therapy of patients with acute respiratory diseases]. Voenno-meditsinskii zhurnal, 2006, Volume: 327, Issue:10 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics; Antioxidants; Antiviral Agents; Ascorbi	2006
Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial. Annals of emergency medicine, 2007, Volume: 49, Issue:5 Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Analges	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics, 2007, Volume: 119, Issue:3 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics	2007
Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:4 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method	2007
Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relieving symptoms of acute nasopharyngitis in children? A randomised, controlled trial. International journal of pediatric otorhinolaryngology, 2007, Volume: 71, Issue:8 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Child, Preschool; Diphenhydramine; Dr	2007
Caudal epidural injection versus non-steroidal anti-inflammatory drugs in the treatment of low back pain accompanied with radicular pain. Joint bone spine, 2007, Volume: 74, Issue:5 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	2007
Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. Lancet (London, England), 2007, Nov-10, Volume: 370, Issue:9599 Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Hu	2007
A comparison of two analgesic muscle relaxant combinations in acute back pain. The British journal of clinical practice, 1984, Volume: 38, Issue:3 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aspirin; Back Pain; Caffeine; Carisoprodol; C	1984
[Evaluation of the analgesic effect of UP 341-01 in patients presenting with acute pain in ORL]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Oct-27, Volume: 59, Issue:39 Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injection	1983
A double-blind comparison of meptazinol versus distalgesic in acute of chronic pain presenting to the general practitioner. The Journal of international medical research, 1982, Volume: 10, Issue:2 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Azepines; Chronic Disease; Dextropropoxyphene	1982
Naproxen sodium and paracetamol/dextropropoxyphene in sports injuries - a multicentre comparative study. British journal of sports medicine, 1982, Volume: 16, Issue:2 Topics: Acetaminophen; Acute Disease; Adult; Athletic Injuries; Bone Diseases; Dextropropoxyphene; Drug Comb	1982
A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. Current medical research and opinion, 1982, Volume: 8, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Azepines; Chronic Disease; Double-Blind Method; Female; Humans;	1982
Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa. Journal of clinical pathology, 1981, Volume: 34, Issue:8 Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents; Chronic Disease; Dextropropoxyphene;	1981
Antipyretic and anti-inflammatory efficacy of nimesulide vs paracetamol in the symptomatic treatment of acute respiratory infections in children. Drugs, 1993, Volume: 46 Suppl 1 Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chi	1993
Clinical and pharmacokinetic study of nimesulide in children. Drugs, 1993, Volume: 46 Suppl 1 Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Fema	1993
A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chi	1996
Ketoprofen versus paracetamol in the treatment of acute migraine. Headache, 1997, Volume: 37, Issue:1 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid	1997
Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. Annals of emergency medicine, 1998, Volume: 32, Issue:2 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcoti	1998
Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. Anesthesia and analgesia, 1998, Volume: 87, Issue:2 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesia, Patient-Cont	1998
Allogeneic peripheral blood stem cell transplantation in acute non-lymphoblastic leukemia. Hematological oncology, 1998, Volume: 16, Issue:4 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Blood Transfusion; Chroni	1998
A comparison of ketorolac tromethamine and acetaminophen codeine in the management of acute apical periodontitis. Journal of endodontics, 1999, Volume: 25, Issue:4 Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-	1999
The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics, 1999, Volume: 104, Issue:4 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method;	1999
Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. Southern medical journal, 1999, Volume: 92, Issue:12 Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Body Temperature; Doub	1999
Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. European journal of clinical pharmacology, 1999, Volume: 55, Issue:9 Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Infla	1999
Behavioural measurement of postoperative pain after oral surgery. The British journal of oral & maxillofacial surgery, 2000, Volume: 38, Issue:2 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Alveolectomy; Analgesia; Analgesics; Analgesics, No	2000
Stroke severity determines body temperature in acute stroke. Stroke, 2001, Volume: 32, Issue:2 Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Body Temperature; Cerebral He	2001
Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ (Clinical research ed.), 2001, Feb-10, Volume: 322, Issue:7282 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Bias; Child; Child, P	2001
Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. Stroke, 2001, Volume: 32, Issue:7 Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; F	2001
Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. Stroke, 2002, Volume: 33, Issue:1 Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Double-Blind Method; Female; Fever; Humans; Hy	2002
Continuous low-level heat wrap therapy provides more efficacy than Ibuprofen and acetaminophen for acute low back pain. Spine, 2002, May-15, Volume: 27, Issue:10 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Female; Follow-Up Studies	2002
Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. Lancet (London, England), 1976, Jan-17, Volume: 1, Issue:7951 Topics: Acetaminophen; Acute Disease; Adult; Age Factors; Aged; Aspartate Aminotransferases; Bile Acids and	1976
A controlled clinical trial of a muscle relaxant analgesic combination in the treatment of acute lumbago. The British journal of clinical practice, 1976, Volume: 30, Issue:3 Topics: Acetaminophen; Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Drug Evaluation; Drug Ther	1976
Phase I study of neocarzinostatin in patients with acute leukemia. Cancer treatment reports, 1978, Volume: 62, Issue:9 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Child; Clinical	1978
[Symptomatic treatment of acute inflammation of the upper respiratory airways in pediatrics]. Minerva pediatrica, 1977, Feb-18, Volume: 29, Issue:5 Topics: Acetaminophen; Acute Disease; Analgesics; Animals; Child, Preschool; Clinical Trials as Topic; Drug	1977
N-acetyl-p-amino-phenol (paracetamol, acetaminophen) in the treatment of acute schizophrenia. Psychological medicine, 1978, Volume: 8, Issue:3 Topics: Acetaminophen; Acute Disease; Body Temperature; Circadian Rhythm; Double-Blind Method; Female; Human	1978
Treatment of migraine attacks with an analgesic combination (Mersyndol). The Medical journal of Australia, 1976, Jun-05, Volume: 1, Issue:23 Topics: Acetaminophen; Acute Disease; Caffeine; Clinical Trials as Topic; Codeine; Doxylamine; Drug Combinat	1976
[Treatment of acute rheumatic diseases with Probaphen in private medicine]. ZFA. Zeitschrift fur Allgemeinmedizin, 1976, Oct-10, Volume: 52, Issue:28 Topics: Acetaminophen; Acute Disease; Aminopyrine; Clinical Trials as Topic; Dipyrone; Drug Combinations; Dr	1976
A controlled trial of cysteamine in the treatment of acute paracetamol poisoning. The Journal of international medical research, 1976, Volume: 4, Issue:4 Suppl Topics: Acetaminophen; Acute Disease; Adult; Cysteamine; Humans; Liver; Liver Function Tests; Suicide	1976
Treatment of acute migraine attack with diclofenac sodium: a double-blind study. Headache, 1992, Volume: 32, Issue:2 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Diclofenac; Double-Blind Method; Female; Huma	1992
Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin. Lancet (London, England), 1991, Mar-09, Volume: 337, Issue:8741 Topics: Acetaminophen; Acute Disease; Child; Child, Preschool; Double-Blind Method; Drug Administration Sche	1991
[Efficacy and tolerability of tiaprofenic acid (Surgam) in acute sinusitis in adults. Results of a randomized study versus paracetamol and placebo]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1991, Volume: 108, Issue:6 Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Humans; Placebos; Prop	1991
Acute red ear in children: controlled trial of non-antibiotic treatment in general practice. BMJ (Clinical research ed.), 1991, Sep-07, Volume: 303, Issue:6802 Topics: Acetaminophen; Acoustic Impedance Tests; Acute Disease; Amoxicillin; Child; Child, Preschool; Crying	1991
Hydrocodone versus codeine in acute musculoskeletal pain. Annals of emergency medicine, 1991, Volume: 20, Issue:10 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Codeine; Double-Blind Method; Drug Combinatio	1991
Ibuprofen and acetaminophen in the relief of acute pain: a randomized, double-blind, placebo-controlled study. Journal of clinical pharmacology, 1989, Volume: 29, Issue:11 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Double-Blind Method; Female; Humans; Ibuprofen; Mal	1989
Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. The Journal of family practice, 1986, Volume: 23, Issue:2 Topics: Acetaminophen; Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Codeine; Diflunisal; Drug	1986
Mefenamic acid, chlormezanone-paracetamol, ethoheptazine-aspirin-meprobamate: a comparative study in acute low back pain. The British journal of clinical practice, 1987, Volume: 41, Issue:2 Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics; Aspirin; Azepines; Back Pain; Chl	1987
Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. Arzneimittel-Forschung, 1985, Volume: 35, Issue:11 Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Child; Chil	1985
Efficacy of fixed combination antibiotics versus separate components in otitis media. Effectiveness of erythromycin estrolate, triple sulfonamide, ampicillin, erythromycin estolate- triple sulfonamide, and placebo in 280 patients with acute otitis media u Clinical pediatrics, 1972, Volume: 11, Issue:4 Topics: Acetaminophen; Acute Disease; Ampicillin; Child, Preschool; Chlorpheniramine; Drug Combinations; Ery	1972

Intervention	participants (Number)
	Nausea	Vomiting	Fever	Itching	Rash	Sweating	Dizziness	Headache	Constipation	Oversedation	Tonsil bleed
Capital® With Codeine Suspension	20	21	11	5	1	9	15	12	21	14	3
Tramadol Suspension	20	18	10	12	1	7	17	17	21	8	0

acetaminophen and Acute Disease