acetaminophen has been researched along with Acute Brain Injuries in 13 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Asthenia is a key symptom of posttraumatic disorders (postcommotion syndrom)." | 2.73 | [The use of enerion in the treatment of asthenic disorders in patients after mild cranio-cerebral trauma]. ( Levin, OS; Slizkova, IuB, 2007) |
| "Among first-line methods to treat fever, ice packs were the most frequently utilized physical method (n=90, [47%]), external nonautomated system was the most frequent utilized device (n=49, [25%]), and paracetamol was the most frequently utilized drug (n=135, [70%])." | 1.51 | A Survey on Fever Monitoring and Management in Patients With Acute Brain Injury: The SUMMA Study. ( Helbok, R; Oddo, M; Picetti, E; Prisco, L; Taccone, FS, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Picetti, E | 1 |
| Oddo, M | 1 |
| Prisco, L | 1 |
| Helbok, R | 1 |
| Taccone, FS | 1 |
| Saxena, MK | 2 |
| Taylor, CB | 1 |
| Hammond, NE | 1 |
| Young, PJ | 1 |
| Seppelt, IM | 1 |
| Glass, P | 1 |
| Myburgh, JA | 1 |
| Taylor, C | 1 |
| Billot, L | 1 |
| Bompoint, S | 1 |
| Gowardman, J | 1 |
| Roberts, JA | 1 |
| Lipman, J | 1 |
| Myburgh, J | 1 |
| Mrozek, S | 1 |
| Constantin, JM | 1 |
| Futier, E | 1 |
| Zenut, M | 1 |
| Ghardes, G | 1 |
| Cayot-Constantin, S | 1 |
| Bonnard, M | 1 |
| Ait-Bensaid, N | 1 |
| Eschalier, A | 1 |
| Bazin, JE | 1 |
| Kuo, JR | 1 |
| Lo, CJ | 1 |
| Wang, CC | 1 |
| Lu, CL | 1 |
| Lin, SC | 1 |
| Chen, CF | 1 |
| van der Marel, CD | 1 |
| Anderson, BJ | 1 |
| Pluim, MA | 1 |
| de Jong, TH | 1 |
| Gonzalez, A | 1 |
| Tibboel, D | 1 |
| Geffroy, A | 1 |
| Bronchard, R | 1 |
| Merckx, P | 1 |
| Seince, PF | 1 |
| Faillot, T | 1 |
| Albaladejo, P | 1 |
| Marty, J | 1 |
| Brown, JM | 1 |
| Udomphorn, Y | 1 |
| Suz, P | 1 |
| Vavilala, MS | 1 |
| Hata, JS | 1 |
| Shelsky, CR | 1 |
| Hindman, BJ | 1 |
| Smith, TC | 1 |
| Simmons, JS | 1 |
| Todd, MM | 1 |
| Levin, OS | 1 |
| Slizkova, IuB | 1 |
| McArthur, CJ | 1 |
| Gin, T | 1 |
| McLaren, IM | 1 |
| Critchley, JA | 1 |
| Oh, TE | 1 |
| Mellergård, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
6 trials available for acetaminophen and Acute Brain Injuries
| Article | Year |
|---|---|
Temperature management in patients with acute neurological lesions: an Australian and New Zealand point prevalence study.
Topics: Acetaminophen; Antipyretics; Australia; Body Temperature; Brain Injuries; Dose-Response Relationship | 2013 |
The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial.
Topics: Acetaminophen; Adult; Antipyretics; Body Temperature; Brain Injuries; Double-Blind Method; Female; F | 2015 |
Acetaminophen in cerebrospinal fluid in children.
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Bayes Theorem; Body Weight; Brain | 2003 |
A prospective, observational clinical trial of fever reduction to reduce systemic oxygen consumption in the setting of acute brain injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Body Temperature; Brain Injuries; Combined M | 2008 |
[The use of enerion in the treatment of asthenic disorders in patients after mild cranio-cerebral trauma].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthenia; Brain Injuries; Female; Humans; Male; Midd | 2007 |
Gastric emptying following brain injury: effects of choice of sedation and intracranial pressure.
Topics: Acetaminophen; Adult; Brain Injuries; Conscious Sedation; Drug Therapy, Combination; Female; Gastric | 1995 |
7 other studies available for acetaminophen and Acute Brain Injuries
| Article | Year |
|---|---|
A Survey on Fever Monitoring and Management in Patients With Acute Brain Injury: The SUMMA Study.
Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Body Tem | 2019 |
[Acetaminophene-induced hypotension in intensive care unit: a prospective study].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Brain Injuries; Endpoint Determinatio | 2009 |
Intravenous paracetamol and arterial hypotension. Especially in cases of infection or brain damage.
Topics: Acetaminophen; Brain Injuries; France; Humans; Hypotension; Infections; Injections, Intravenous; Pro | 2009 |
Measuring brain temperature while maintaining brain normothermia in patients with severe traumatic brain injury.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Body Temperatur | 2011 |
Severe traumatic head injury in adults: which patients are at risk of early hyperthermia?
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Temperature; Brain Injuries; Female; Fever; Hum | 2004 |
Antipyretic treatment of noninfectious fever in children with severe traumatic brain injury.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Brain Injuries; Child; Child, Preschool; Dose- | 2008 |
Monitoring of rectal, epidural, and intraventricular temperature in neurosurgical patients.
Topics: Acetaminophen; Body Temperature Regulation; Brain Damage, Chronic; Brain Diseases; Brain Injuries; C | 1994 |