acetaminophen has been researched along with Acquired Immunodeficiency Syndrome in 10 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When AIDS patients treated with zidovudine were compared with those not given this medication, differences in the urinary excretion of acetaminophen and its metabolites were not observed." | 2.68 | Abnormalities in the metabolism of acetaminophen in patients infected with the human immunodeficiency virus (HIV). ( Boix, V; Esteban, A; González, M; Mora, A; Pérez-Mateo, M; Portilla, J, 1997) |
| "The target population was HIV and AIDS patients who had been using the primary health clinic for chronic pain management." | 1.39 | The management of HIV- and AIDS-related pain in a primary health clinic in Tshwane, South Africa. ( Dreyer Wright, SC; Makua, MR; Maree, JE, 2013) |
| "No effect of disease state, AIDS vs asymptomatic HIV positive vs control, on APAP glucuronidation or sulphation was observed." | 1.30 | Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS. ( Di Girolamo, A; O'Neil, WM; Pezzullo, JC; Tsoukas, CM; Wainer, IW, 1999) |
| "To investigate a possible pharmacokinetic interaction between zidovudine and paracetamol." | 1.29 | Short-term, combined use of paracetamol and zidovudine does not alter the pharmacokinetics of either drug. ( Beijnen, JH; Burger, DM; Koks, CH; Meenhorst, PL; Underberg, WJ; van der Heijde, JF, 1994) |
| " No influence on other pharmacokinetic parameters of either drug could be detected." | 1.29 | Pharmacokinetics of zidovudine and acetaminophen in a patient on chronic acetaminophen therapy. ( Beijnen, JH; Burger, DM; Koks, CH; Meenhorst, PL, 1994) |
| " Additionally, due to malnutrition and/or to human immunodeficiency virus infection per se, our patient may have had decreased hepatic reserves of glutathione with which to conjugate the toxic acetaminophen product of the P450 system." | 1.28 | Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine. ( Goetz, MB; Shriner, K, 1992) |
| "Because serum concentrations of zidovudine decrease after the coadministration of acetaminophen, a pharmacokinetic interaction between zidovudine and acetaminophen is unlikely to increase the risk for hematologic toxicity associated with zidovudine." | 1.28 | Acetaminophen does not impair clearance of zidovudine. ( Antoniskis, D; Cohen, J; Ko, R; Koda, R; Leedom, J; Nicoloff, J; Sattler, FR; Shields, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maree, JE | 1 |
| Dreyer Wright, SC | 1 |
| Makua, MR | 1 |
| Burger, DM | 2 |
| Meenhorst, PL | 2 |
| Underberg, WJ | 1 |
| van der Heijde, JF | 1 |
| Koks, CH | 2 |
| Beijnen, JH | 2 |
| Spapen, H | 1 |
| Zhang, H | 1 |
| Gillet, R | 1 |
| De Wit, N | 1 |
| Huyghens, L | 1 |
| Esteban, A | 1 |
| Pérez-Mateo, M | 1 |
| Boix, V | 1 |
| González, M | 1 |
| Portilla, J | 1 |
| Mora, A | 1 |
| Di Girolamo, A | 2 |
| O'Neill, WM | 1 |
| Wainer, IW | 2 |
| O'Neil, WM | 1 |
| Pezzullo, JC | 1 |
| Tsoukas, CM | 1 |
| Shriner, K | 1 |
| Goetz, MB | 1 |
| Sattler, FR | 1 |
| Ko, R | 1 |
| Antoniskis, D | 1 |
| Shields, M | 1 |
| Cohen, J | 1 |
| Nicoloff, J | 1 |
| Leedom, J | 1 |
| Koda, R | 1 |
| Nicholas, SW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Interaction Between Acetaminophen and Zidovudine[NCT00000731] | 10 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetaminophen and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders].
Topics: Acetaminophen; Acetylcysteine; Acquired Immunodeficiency Syndrome; Antioxidants; Chemical and Drug I | 1994 |
1 trial available for acetaminophen and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Abnormalities in the metabolism of acetaminophen in patients infected with the human immunodeficiency virus (HIV).
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Analgesics, Non-Narcotic; Antiviral Agents | 1997 |
8 other studies available for acetaminophen and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
The management of HIV- and AIDS-related pain in a primary health clinic in Tshwane, South Africa.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Analgesics, Non-Narcotic | 2013 |
Short-term, combined use of paracetamol and zidovudine does not alter the pharmacokinetics of either drug.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Drug Interactions; Drug Therapy, Combinati | 1994 |
Pharmacokinetics of zidovudine and acetaminophen in a patient on chronic acetaminophen therapy.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Drug Administration | 1994 |
A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.
Topics: Acetaminophen; Acetonitriles; Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liqu | 1998 |
Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Cross-Sectional Studies; Disease Progressi | 1999 |
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Chemical and Drug Induced Liver Injury; Hu | 1992 |
Acetaminophen does not impair clearance of zidovudine.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Analysis of Variance | 1991 |
Guidelines for the care of children and adolescents with HIV infection. Management of the HIV-positive child with fever.
Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Child; Fever; HIV Infections; HIV Seropositivity; | 1991 |