acetaminophen has been researched along with Acidosis, Lactic in 14 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 7.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| " Several patients with lactic acidosis and glucose levels below 1." | 7.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 3.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| " Hemodialysis appears to be a beneficial therapeutic option in cases of massive acetaminophen ingestion with coma and lactic acidosis." | 3.83 | Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. ( Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E, 2016) |
| " Several patients with lactic acidosis and glucose levels below 1." | 3.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "Haemodialysis is sometimes used for patients with massive acetaminophen overdose when signs of "mitochondrial paralysis" (lactic acidosis, altered mental status, hypothermia and hyperglycaemia) are present." | 3.79 | Antidote removal during haemodialysis for massive acetaminophen overdose. ( Garland, JS; Hanly, LN; Juurlink, DN; Lenga, I; Poley, R; Sivilotti, ML; Thompson, M, 2013) |
| " These disturbances are often associated with acetaminophen in the setting of certain risk factors such as sepsis, malnutrition, liver disease, female gender, pregnancy or renal failure." | 3.78 | Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon. ( Flemmer, M; Hooper, M; Marik, PE; O'Brien, LM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levine, M | 1 |
| Stellpflug, SJ | 1 |
| Pizon, AF | 1 |
| Peak, DA | 1 |
| Villano, J | 1 |
| Wiegand, T | 1 |
| Dib, C | 1 |
| Thomas, SH | 1 |
| Bitton, JB | 1 |
| Wang, JJ | 1 |
| Teng, W | 1 |
| Villeneuve, E | 2 |
| Gosselin, S | 2 |
| Taub, ES | 1 |
| Hoffman, RS | 1 |
| Manini, AF | 1 |
| Sivilotti, ML | 1 |
| Juurlink, DN | 1 |
| Garland, JS | 1 |
| Lenga, I | 1 |
| Poley, R | 1 |
| Hanly, LN | 1 |
| Thompson, M | 1 |
| Oldenbeuving, G | 1 |
| McDonald, JR | 1 |
| Goodwin, ML | 1 |
| Sayilir, R | 1 |
| Reijngoud, DJ | 1 |
| Gladden, LB | 1 |
| Nijsten, MW | 1 |
| Schneider, F | 1 |
| Poidevin, A | 1 |
| Riehm, S | 1 |
| Herbrecht, JE | 1 |
| Guillot, M | 1 |
| Villano, JH | 1 |
| O'Connell, CW | 1 |
| Ly, BT | 1 |
| Schneir, A | 1 |
| Ghannoum, M | 1 |
| Kazim, S | 1 |
| Grunbaum, AM | 1 |
| Serjeant, L | 1 |
| Evans, J | 1 |
| Sampaziotis, F | 1 |
| Petchey, WG | 1 |
| Zein, JG | 1 |
| Wallace, DJ | 1 |
| Kinasewitz, G | 1 |
| Toubia, N | 1 |
| Kakoulas, C | 1 |
| Shah, AD | 1 |
| Wood, DM | 1 |
| Dargan, PI | 1 |
| O'Brien, LM | 1 |
| Hooper, M | 1 |
| Flemmer, M | 1 |
| Marik, PE | 1 |
| Dunn, RJ | 1 |
| Gray, TA | 1 |
| Buckley, BM | 1 |
| Vale, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for acetaminophen and Acidosis, Lactic
| Article | Year |
|---|---|
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
Topics: Acetaminophen; Acidosis, Lactic; Adult; Blood Coagulation Disorders; Chemical and Drug Induced Liver | 2018 |
Letter in reply to Levine et al. Re: hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; H | 2018 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Antidote removal during haemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; C | 2013 |
A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Blood Glucose; Follow-Up Studies; Humans; | 2014 |
Liver transplantation in case of acetaminophen poisoning: importance of assessment of the colon if arterial lactate increases despite appropriate care.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; C | 2014 |
Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Antidotes; Biomarkers; Coma; Drug Overdose; | 2015 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, | 2016 |
Haemodialysis in acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2017 |
Early anion gap metabolic acidosis in acetaminophen overdose.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis, Lactic; Adult; Analgesics, Non-Narcotic; Analysis of | 2010 |
Understanding lactic acidosis in paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acidosis, Lactic; Drug Overdose; Female; Humans; Liver Failure, Acute; Male; Prognosi | 2011 |
Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis, Lactic; Analgesics, Non-Narcotic; Chronic Disease; D | 2012 |
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blo | 1998 |
Hyperlactataemia and metabolic acidosis following paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Female; | 1987 |