Page last updated: 2024-10-22

acetaminophen and Ache

acetaminophen has been researched along with Ache in 1152 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
" Acetaminophen, the active ingredient found in Tylenol, is among the most common pain medications consumed."9.69Acetaminophen changes Mu rhythm power related to pain empathy. ( Jelsone-Swain, L; McCommon, SA; Roach, A; Turk, B, 2023)
"This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)."9.51The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022)
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."9.51The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Intranasal fentanyl seems to be a safe and effective alternative to acetaminophen with hydrocodone in reducing pain and improving hydration status in children with painful infectious mouth lesions and poor oral intake."9.51Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions. ( Chen, JG; Cramm, K; Florez, C; Papa, L; Ramirez, J; Ruffin, TB; Salinero, E, 2022)
" The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography."9.51Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022)
" Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo."9.51Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study. ( Aktaş, N; Arslan, E; Aydın, İ; Gülaçtı, U; Sönmez, C; Turgut, K; Yavuz, E, 2022)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."9.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"The study aimed to compare the acetaminophen administration efficacy or its combination with codeine for pain control in acute apical abscesses cases."9.41Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial. ( Cardoso, MBF; da Rosa, RA; da Silva, PB; do Nascimento, AL; Mendes, AT; Pereira, JR; Só, MVR, 2021)
" The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)."9.41Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021)
" Lidocaine given intravenously has been shown in two small, uncontrolled studies to have an appreciable effect on pain after burns."9.34Lidocaine infusion has a 25% opioid-sparing effect on background pain after burns: A prospective, randomised, double-blind, controlled trial. ( Abdelrahman, I; Elmasry, M; Sjoberg, F; Steinvall, I, 2020)
"The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial."9.34Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020)
"To evaluate the effectiveness of verbal behavior modification, acetaminophen, and the combined effectiveness of verbal behavior modification along with acetaminophen on orthodontic pain."9.30A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. ( Abraham, R; Bansal, N; Kaur, H, 2019)
"We addressed these issues by investigating how acetaminophen administration and daily forgiveness are associated with experiences of social pain over 21 days."9.30Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen. ( Deal, BD; Gregory, A; Shields, GS; Slavich, GM; Toussaint, LL, 2019)
" Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups."9.30Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. ( Azami, A; Enteshari-Moghaddam, A; Habibzadeh, A; Isazadehfar, K; Jahanpanah, P; Mohebbi, H, 2019)
"To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection."9.30Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. ( Jongjidpranitarn, M; Nimmaanrat, S; Oofuvong, M; Prathep, S, 2019)
"There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED."9.27Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. ( Cattermole, GN; Graham, CA; Hung, KKC; Leung, LY; Leung, YK; Lo, RSL; Man, SY; Rainer, TH; Woo, WK, 2018)
"The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features."9.27Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018)
"To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department."9.27Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018)
"This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery."9.27Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. ( de Kam, ML; Groeneveld, GJ; Hay, JL; Siebenga, P; van Amerongen, G, 2018)
"Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants."9.22Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022)
"HNC patients (pts) receiving CRT were randomized to standard pain control (SPC) with acetaminophen and opioids, or SPC plus gabapentin (SPC+G)."9.22Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer. ( Chayahara, N; Fujiwara, Y; Funakoshi, Y; Kataoka, T; Kiyota, N; Komori, T; Minami, H; Mukohara, T; Nibu, K; Sasaki, R; Shimada, T; Toyoda, M, 2016)
"The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator."9.22Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial. ( Ghadirian, H; Hosseinzadeh Nik, T; Ostad, SN; Shahsavari, N, 2016)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."9.22Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"Although liposomal bupivacaine had some effect on soft tissue anesthesia, it did not reduce pain to manageable clinical levels in patients presenting with untreated, symptomatic irreversible pulpitis."9.22Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( Beck, M; Bultema, K; Drum, M; Fowler, S; Nusstein, J; Reader, A, 2016)
" Significant reduction in pain intensity was observed with topical lidocaine group when compared with the ice application group (p < 0."9.20A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings. ( Aksel, G; Çorbacioğlu, ŞK; Doğan, NÖ; Güler, S, 2015)
"To evaluate the efficacy and safety profile of paracetamol in comparison with tramadol for pain relief during active labor."9.20Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor. ( Bhatia, N; Jain, K; Jain, V; Kaur Makkar, J; Mal Mithrawal, S, 2015)
"To test the analgesic efficacy of oxymorphone hydrochloride (OH) and propoxyphene/acetaminophen (PA) for patients with neurogenic claudication associated with lumbar spinal stenosis."9.20A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis. ( Chowdhry, AK; Dworkin, RH; Frazer, ME; Gewandter, JS; Markman, JD; McDermott, MP; Murray, NM; Pilcher, WH; Rast, SA; Tomkinson, EJ; Walter, KA, 2015)
"Acetaminophen, an effective and popular over-the-counter pain reliever (e."9.20Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli. ( Durso, GR; Luttrell, A; Way, BM, 2015)
"This study aims to evaluate and compare the effect of pre-procedural administration of acetaminophen, ibuprofen, and meloxicam in reducing pain after separator placement."9.20Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. ( Babanouri, N; Oshagh, M; Salehi, P; Torkan, S; Zarif Najafi, H, 2015)
"The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used."9.20Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015)
"9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0."9.19Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014)
"A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair."9.19Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014)
"This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)."9.19Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. ( Bijur, PE; Chang, AK; John Gallagher, E; Munjal, KG, 2014)
"Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain."9.19Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014)
"Rocuronium is a nondepolarizing neuromuscular blocking agent used in anesthesia induction and is associated with considerable discomfort and burning pain during injection, which is reported to occur in 50-80% of patients."9.19The effect of intravenous paracetamol for the prevention of rocuronium injection pain. ( Aypar, U; Canbay, O; Erden, IA; Uzun, S, 2014)
" We explore whether the neural mechanism that responds to meaning threats can be inhibited by acetaminophen, in the same way that acetaminophen inhibits physical pain or the distress caused by social rejection."9.17The common pain of surrealism and death: acetaminophen reduces compensatory affirmation following meaning threats. ( Heine, SJ; Randles, D; Santos, N, 2013)
" To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application."9.17Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013)
"Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing."9.16Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012)
"5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) with that of nonsteroidal anti-inflammatory drugs (NSAIDs) as maintenance therapy following tramadol/APAP and NSAID combination therapy in knee osteoarthritis (OA) pain which was inadequately controlled by NSAIDs."9.16The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). ( Cho, CS; Choi, JJ; Kim, WU; Min, JK; Park, KS; Park, SH, 2012)
"The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease."9.15Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients. ( Kang, P; Li, J; Liu, G; Liu, W; Luo, R; Ma, X; Pei, F; Shen, B; Xie, Q; Zhou, Z, 2011)
"We tested whether paracetamol could improve pain relief in patients visiting the emergency department with acute renal colic as compared to piroxicam, a nonsteroidal anti-inflammatory drug (NSAID)."9.15Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial. ( Boubaker, H; Boudhib, L; Bouida, W; Boukef, R; Claessens, YE; Grissa, MH; Kerkeni, W; Nouira, S, 2011)
"To evaluate the efficacy and safety of the paracetamol-tramadol combination (PTC) in treating moderate-to-severe pain, in patients aged 65 years and over within general practitioner (GP) practice centers."9.15Epidemiological data, efficacy and safety of a paracetamol-tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practice. ( Ganry, H; Mejjad, O; Serrie, A, 2011)
" The effects of acetaminophen, tropisetron, the combination of both drugs, and saline on pain perception and central sensitization in healthy volunteers were compared."9.15Tropisetron blocks analgesic action of acetaminophen: a human pain model study. ( Bandschapp, O; Filitz, J; Koppert, W; Ruppen, W; Urwyler, A, 2011)
"Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis."9.15A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011)
"A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care."9.15A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011)
"The present study aimed to examine the effectiveness of intravenous administration of paracetamol added to morphine in the control of cancer pain and its possible contribution as reduction of opioid consumption and opioid-related side effects."9.14Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control. ( Aydinli, I; Keskinbora, K; Pekel, AF; Salihoglu, T; Sonsuz, A; Tasmacioglu, B, 2009)
"This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee."9.14Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa ( Berggren, AC; Karlsson, M, 2009)
"To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)."9.14Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009)
"This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting."9.14Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. ( Friday, JH; Harley, JR; Kanegaye, JT; McCaslin, I; Zheng, A, 2009)
"We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)."9.14A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009)
"5 mg kg(-1) for prevention of propofol induced pain."9.14Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol. ( Borazan, H; Erdem, TB; Kececioglu, M; Otelcioglu, S, 2010)
"This study suggests that paracetamol, lornoxicam, and tramadol can be safely and efficiently preferred in pain control during SWL."9.14Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol representing three different groups of analgesics for pain control in extracorporeal shockwave lithotripsy. ( Akcali, GE; Balcioglu, YO; Cam, K; Demiraran, Y; Iskender, A; Kayikci, A; Yalcin, GS, 2010)
"To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain."9.14Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010)
"This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy."9.14Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010)
" They were randomized to receive ibuprofen or paracetamol when pain relief was necessary."9.14Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study. ( David, LB; Livshits, A; Machtinger, R; Moshe-Zahav, A; Seidman, DS; Spira, M, 2009)
" Aim of this study was to examine the analgesic and antihyperalgesic properties of the weak opioid tramadol and the non-opioid acetaminophen, alone as well as in combination, in an experimental pain model in humans."9.13Supra-additive effects of tramadol and acetaminophen in a human pain model. ( Filitz, J; Günther, W; Ihmsen, H; Koppert, W; Schüttler, J; Schwilden, H; Tröster, A, 2008)
" acetaminophen seems to be effective in attenuating pain during i."9.13Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain. ( Arun, O; Canbay, O; Celebi, N; Karagöz, AH; Ozgen, S; Saricaoğlu, F, 2008)
"To examine, in routine practice, the effectiveness and cost-effectiveness of oxycodone (OxyContin) compared with standard therapy for osteoarthritis pain."9.12Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee. ( Buitendyk, M; Codding, C; Marshall, DA; Pericak, D; Strauss, ME; Torrance, GW, 2006)
"In this double-blind cross-over study, we assessed whether erythromycin infusion is effective as a prokinetic drug against gastroparesis from acute pain."9.12Erythromycin promotes gastric emptying during acute pain in volunteers. ( Allaouchiche, B; Bleyzac, N; Boselli, E; Bouvet, L; Chassard, D; Duflo, F; Mion, F, 2006)
"Administering 75 mg tramadol/650 mg acetaminophen orally with periprostatic 1% lidocaine before transrectal ultrasound guided prostate biopsy is a safe, easy and effective method of controlling pain during the biopsy procedure."9.12Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial. ( Carvin, DM; Costa, J; Pendleton, J; Rosser, CJ; Wludyka, P, 2006)
"The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC)."9.12Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. ( Bey, M; Burnett, I; Grattan, T; Littlejohn, S; Sanner, K; Schachtel, B, 2006)
"0001) and was superior to pseudoephedrine and placebo for pain relief (p < or = 0."9.12Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. ( Burnett, I; Eccles, R; Jawad, M; Jawad, S; Jones, E; North, M; Ridge, D, 2006)
"5-mg/acetaminophen 325-mg combination tablets (tramadoUAPAP) as add-on therapy in subjects with rheumatoid arthritis (RA) pain that was inadequately controlled by NSAIDs and disease-modifying antirheumatic drugs alone."9.12Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial. ( Baek, HJ; Kim, HA; Lee, CK; Lee, EB; Lee, EY; Lim, MK; Park, BJ; Seo, YI; Sheen, DH; Shim, SC; Song, YW; Yoo, B, 2006)
"Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries."9.12A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007)
"Combined tramadol/acetaminophen is used to treat pain related to osteoarthritis."9.12A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain. ( Bae, SC; Choe, JY; Choi, CB; Chung, WT; Hong, YH; Ji, JD; Kang, YM; Kim, HA; Kim, TH; Lee, CK; Lee, J; Lee, JT; Lim, MK; Nam, EJ; Park, SH; Seo, YI; Sheen, DH; Shim, SC; Song, GG; Song, JS; Suh, CH; Sung, YK, 2007)
"This study compared the efficacy and safety profile of buprenorphine transdermal delivery system (BTDS) and placebo in subjects with persistent noncancer-related pain who required opioid analgesics."9.12Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study. ( Carr, WD; Landau, CJ; Munera, C; Razzetti, AJ; Ripa, SR; Sessler, NE, 2007)
"It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries."9.12The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium. ( Agus, H; Kayali, C; Surer, L; Turgut, A, 2007)
"5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)."9.11Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004)
"5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients."9.11Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004)
"To compare the effects of providing analgesia with either transdermal fentanyl (TTS-fentanyl) or paracetamol and codeine (P/C) in addition to radiotherapy in patients with metastatic bone pain."9.11Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. ( Eleftheriadis, N; Georgakopoulos, G; Gompakis, N; Kouloulias, VE; Kouvaris, J; Mystakidou, K; Pistevou-Gompaki, K; Varveris, C, 2004)
"In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of >or= 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (singledose phase) followed by 5/325 mg every 6h as needed (multidose phase), or placebo."9.11Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. ( Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA, 2004)
"To determine in a sample of nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of acetaminophen in reducing discomfort."9.11A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia. ( Brod, M; Buffum, MD; Miaskowski, C; Sands, L; Washburn, A, 2004)
"To determine whether adding regular acetaminophen (paracetamol) could improve pain and well-being in people with advanced cancer and pain despite strong opioids."9.11Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial. ( Pillai, A; Stockler, M; Vardy, J; Warr, D, 2004)
"It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of nasal congestion associated with the common cold."9.11Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold. ( Loose, I; Winkel, M, 2004)
"To compare the safety and efficacy of a new cyclooxygenase-2 inhibitor, valdecoxib, with those of an oxycodone-acetaminophen combination in patients with acute musculoskeletal pain."9.11Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. ( Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A, 2004)
"To compare efficacy and safety of strepfen (flurbiprofen) to those of oral paracetamol in acute infections of the upper respiratory tracts for relief of throat pain (TP)."9.11[Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain]. ( Balandin, AV; Dimova, AD; Sedinkin, AA, 2005)
"The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea."9.10Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002)
"2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815)."9.10Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. ( Cairns, R; Le Parc, JM; Moore, N; Schneid, H; van Ganse, E; Wall, R, 2002)
"5 mg tramadol/325 mg acetaminophen) for the treatment of fibromyalgia pain."9.10Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study. ( Bennett, RM; Kamin, M; Karim, R; Rosenthal, N, 2003)
"The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain."9.10Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002)
"Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol."9.09Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol. ( Bhagat, K; Lala, I; Leech, P; Montgomery, L, 2000)
"To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain."9.09Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999)
"This randomized, double-blind, placebo-controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg--an effervescent solution and tablet--in 242 patients with moderate or severe pain following dental surgery."9.09Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. ( Ganry, HE; Insuasty, JH; Møller, PL; Nørholt, SE; Sindet-Pedersen, S; Skoglund, LA; Vincent, FG, 2000)
"5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain."9.09Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000)
"To determine whether greater pain intensity at initiation of treatment predicted better response to ibuprofen than to acetaminophen in subjects with knee osteoarthritis (OA)."9.09Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001)
"Opioid/acetaminophen (APAP) combination analgesics are widely prescribed for the relief of moderate pain."9.09Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. ( Lacy, JR; Mullican, WS, 2001)
"Ibuprofen and acetaminophen with codeine had similar analgesic properties in the first 24 hours post partum (mean pain rating 3."9.09Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. ( Douglas, MJ; Grange, CS; Janssen, PA; Peter, EA, 2001)
"The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia."9.08Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998)
"To evaluate the efficacy of an oral tramadol preparation versus that of an oral hydrocodone-acetaminophen preparation in acute musculoskeletal pain."9.08Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. ( Larkin, GL; Paris, PM; Turturro, MA, 1998)
"Recognizing the concerns about the use of local anesthesia in neonatal circumcision, a painful procedure usually performed without analgesia or anesthesia, we undertook a study of acetaminophen for pain management of this procedure."9.07Acetaminophen analgesia in neonatal circumcision: the effect on pain. ( Howard, CR; Howard, FM; Weitzman, ML, 1994)
"In a double-blind study of 18 patients with coxarthrosis the effect of 3 naproxen doses (0."9.07Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients. ( Neander, G; Samuelson, P; Seideman, P, 1993)
"At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy."9.07Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993)
"Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers."9.07Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity. ( Bromm, B; Forth, W; Richter, E; Scharein, E, 1992)
"In a randomized, double-blind prospective manner, patients received either 5 mg hydrocodone with 500 mg acetaminophen or 30 mg codeine with 500 mg acetaminophen to take on discharge from the ED and every four hours thereafter as needed for pain."9.07Hydrocodone versus codeine in acute musculoskeletal pain. ( Menegazzi, JJ; Paris, PM; Turturro, MA; Yealy, DM, 1991)
"In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day."9.07Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991)
"This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip."9.06Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990)
"Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control."9.06The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988)
"We compared naproxen sodium (550 mg) and propoxyphene napsylate with acetaminophen (PN/A, 100 mg with 650 mg) for pain relief after arthroscopy or arthroscopic meniscectomy."9.06Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen. ( Drez, D; Ritter, M; Rosenberg, TD, 1987)
"To test the hypothesis that the postoperative abdominal pain of tubal occlusion is mediated by prostaglandins, the effects of meclofenamate, a potent inhibitor of cyclooxygenase, on postoperative analgesia and incidence of abdominal pain were compared with those of acetaminophen, a weak inhibitor of prostaglandin activity."9.06Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion. ( Caissie, KF; Huang, KC; Simpson, PM; Tsueda, K; Wolfe, WM, 1986)
"Fifty college athletes with acute sprains and strains from football-related activities were randomly assigned to treatment with either diflunisal or acetaminophen with codeine for seven days."9.06Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. ( Indelicato, PA, 1986)
"Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children."9.05Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020)
"The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study."9.05Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984)
"The efficacy and acceptability of meptazinol and dextropropoxyphene plus paracetamol were compared in 32 elderly patients with various types of musculoskeletal pain."9.05A comparison between meptazinol and dextropropoxyphene plus paracetamol in elderly patients with musculoskeletal pains. ( Orö, L, 1984)
"In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)."9.05A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984)
"A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo."9.05A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982)
"The objectives of this review were to assess the ability of both pharmacological and non-pharmacological interventions to reduce or eliminate the pain that accompanies rocuronium bromide administration."8.93Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. ( Ali, Z; Kalaivani, M; Prabhakar, H; Singh, GP; Smith, MA, 2016)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."8.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"To determine the efficacy and safety of codeine used alone or in combination with paracetamol for relieving cancer pain."8.90Codeine, alone and with paracetamol (acetaminophen), for cancer pain. ( Bell, RF; Derry, S; Jackson, KC; Strassels, S; Straube, C; Straube, S; Wiffen, PJ, 2014)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."8.89Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013)
"Acetaminophen/codeine combination is effective in the treatment of moderate to severe pain in all setting analyzed in this study, which include headache, postoperative, osteoarticular and post-traumatic."8.89Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin. ( Alesi, A; Antonini, EF; Cordischi, C; Franceschi, F; Giacobelli, D; Iacomini, P; Marsiliani, D; Zuccalà, G, 2013)
"To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness."8.88Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012)
"To systematically review the literature on the safety of using nonsteroidal antiinflammatory drugs (NSAID) and/or paracetamol in people receiving methotrexate (MTX) for inflammatory arthritis (IA), as an evidence base for generating clinical practice recommendations."8.88Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review. ( Colebatch, AN; Edwards, CJ; Marks, JL; van der Heijde, DM, 2012)
"Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited."8.87Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."8.86Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010)
"Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage."8.84Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007)
"To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever."8.82Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004)
"To assess the efficiency of paracetamol, indicated in first instance for light-to-moderate pain from hip and knee arthrosis, against rofecoxib, the COX-2 inhibitor most commonly used in Spain."8.82[Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip]. ( Lizán Tudela, L; Magaz Marqués, S; Riesgo Bucher, Y; Varela Moreno, C, 2004)
"The treatment of acute or chronic pain of variable intensity and origin, is efficiently achieved by the association of paracetamol and codeine."8.81[Efficacy and safety of acetaminophen-codeine in the treatment of pain]. ( Hantson, P, 2002)
"In order to assess the analgesia obtained from single oral doses of paracetamol alone and in combination with codeine in postoperative pain, we conducted a systematic review of randomised controlled trials."8.79Paracetamol with and without codeine in acute pain: a quantitative systematic review. ( Carroll, D; Collins, S; McQuay, H; Moore, A, 1997)
"Overall, 74% of women reported acetaminophen use during pregnancy."8.12Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes. ( Bandoli, G; Chambers, C; Killion, JA; Smith, CJF, 2022)
"The inclusion of IV acetaminophen as part of a multimodal pain regimen led to fewer episodes of delirium in this study."7.96Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients. ( Connolly, KP; Kleinman, RS; Mehta, SN; Neuman, MD; Stevenson, KL, 2020)
"Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy."7.96Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. ( Bandoli, G; Chambers, C; Palmsten, K, 2020)
"Paclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment."7.96Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats. ( Brusco, I; Ferreira, J; Hausen, BDS; Moresco, RN; Oliveira, SM; Pinheiro, KV; Rigo, FK, 2020)
"Data of patients treated with a combination of oxycodone (5, 10, and 20 mg) and acetaminophen (325 mg) were evaluated for gender, current disease condition, basal pain intensity, total daily dose, days of controlled pain at the initial low dose, and pain intensity after treatment using a numeric pain rating scale."7.83Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better. ( Carpenedo, R; Dauri, M; Lazzari, M; Mammucari, M; Natoli, S; Palombo, E; Silvi, MB, 2016)
"Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking."7.80Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014)
" Tramadol/acetaminophen medication was effective in reducing pain in seven of nine cases(77."7.79[Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. ( Hirano, M; Kajita, Y; Nakahara, N; Noda, H; Takebayashi, S; Tanei, T; Wakabayashi, T, 2013)
"Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval."7.78Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012)
"This is a pharmacokinetic study of 30 postpartum women receiving hydrocodone bitartrate for postpartum pain in the inpatient setting."7.77Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. ( Anderson, PO; Lane, JR; Nguyen, N; Rafie, S; Rossi, SS; Sauberan, JB; Stellwagen, LM, 2011)
"We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period."7.77Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011)
"The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain."7.76Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010)
"5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients."7.76Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients. ( Chang, CS; Chung, CY; Ho, ML; Hsu, NC; Lin, HY; Wang, CC, 2010)
"The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)."7.74Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007)
"Morphine and other opioids are the mainstay of cancer pain management, yet considerable fears surrounding them present barriers to pain control."7.74Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. ( Gooberman-Hill, R; Hanks, GW; Reid, CM, 2008)
"Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain."7.73Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain. ( Aoe, T; Saito, O; Yamamoto, T, 2005)
"To determine whether multiple dosing of acetaminophen would result in drug accumulation in polymedicated elderly patients with rheumatic pain."7.71Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain. ( Bannwarth, B; Lagrange, F; Le Bars, M; Matoga, M; Maury, S; Palisson, M; Pehourcq, F, 2001)
"(1) This codeine-based syrup is indicated for the treatment of pain in children."7.70Codeine for child pain: new preparation. Helpful in some cases. ( , 1999)
"This retrospective review evaluated the pain management of 395 acutely burned pediatric patients who were treated by a pain management protocol emphasizing acetaminophen as the initial medication to control background pain."7.69Acetaminophen in the management of background pain in children post-burn. ( Blakeney, PE; Cortiella, J; Herndon, DN; Marvin, JA; Meyer, WJ; Nichols, RJ; Villarreal, C, 1997)
" A case of NAS due to codeine prescribed for pain relief during pregnancy is reported."7.69Neonatal abstinence syndrome due to codeine. ( Chang, J; Khan, K, 1997)
"The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat."7.68Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993)
"A comparison was made between the relative effects of aspirin, mefenamic acid, dihydrocodeine , dextropropoxyphene and paracetamol on visceral pain (chemically-inducing writhing), respiratory rate and prostaglandin (PG) biosynthesis (cyclo-oxygenase activity)."7.67Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis. ( Gonzalez, JP; Pugh, J; Sewell, RD, 1984)
"We studied the effects of two non-steroidal anti-inflammatory analgesics (NSAIAs), acetylsalicylic acid (ASA) and acetaminophen, on sleep patterns in rats with adjuvant-induced arthritis."7.67Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989)
"The effectiveness of nonprescription analgesics--acetaminophen and aspirin--in providing subjective relief of preoperative dental pain was evaluated in a varied population of adults."7.66Evaluation of acetaminophen and aspirin in the relief of preoperative dental pain. ( Kilkuts, A; Korberly, BH; Orkand, RK; Schreiber, GF; Segal, H, 1980)
"The pain was scored through a 100-mm visual analog scale (VAS) immediately and 2 h after the procedure."6.82Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial. ( Abbasi, M; Agah, E; Ahmadi, M; Faghihi-Kashani, S; Kalantar, SS; Majedi, H; Tafakhori, A, 2016)
"Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery."6.82Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels. ( Eberhardt, E; Eberhardt, M; Leffler, A; Schillers, F, 2016)
"Acetaminophen (APAP) is a popular analgesic."6.73Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain. ( Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007)
"Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention."6.72Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. ( Brandt, KD; Buckwalter, KA; Mazzuca, SA, 2006)
"Naproxen and ibuprofen were more effective than acetaminophen in minimizing physical side effects of IFN beta-1a."6.71A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. ( Filipi, M; Healey, K; Leuschen, MP, 2004)
" Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited."6.71Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005)
"Pain was related to an infection in 98% of the cases."6.70[Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol]. ( Bernard-Fernier, MF; Cabane, J, 2001)
"CR codeine treatment resulted in significantly lower overall VAS pain intensity scores (35 +/- 18 vs."6.68Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial. ( Arkinstall, W; Babul, N; Darke, AC; Goughnour, B; Harsanyi, Z; Sandler, A, 1995)
"Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine."6.66Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986)
" Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months."6.64Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974)
"His pain was scored as a five on a six-point visual analog scale, and it persisted despite routine supportive therapy."6.50[A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl]. ( Anzai, S; Hashimoto, Y; Nagasawa, K; Suzuki, T, 2014)
"Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects."6.45Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009)
"Acetaminophen is a safe medication that should be considered first-line therapy."6.44Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? ( Choquette, D; Craig, BN; Davis, P; De Angelis, C; Fulthorpe, G; Habal, F; Hunt, RH; Stewart, JI; Turpie, AG, 2007)
"Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events."6.43Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005)
"Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day."6.42Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004)
" In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury."6.41Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000)
"Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity."6.40Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997)
" Antinociception was assessed by dose-response curves to paracetamol and meloxicam before and after the i."5.72Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2022)
" Acetaminophen, the active ingredient found in Tylenol, is among the most common pain medications consumed."5.69Acetaminophen changes Mu rhythm power related to pain empathy. ( Jelsone-Swain, L; McCommon, SA; Roach, A; Turk, B, 2023)
"This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)."5.51The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022)
"We aimed to characterize the current pain experience of patients completing an evidence-based mifepristone-misoprostol medication abortion regimen using real-time pain scores."5.51The experience of pain in real-time during medication abortion. ( Davis, J; Fontanilla, T; Friedlander, EB; Horiuchi, W; Kaneshiro, B; Raidoo, S; Salcedo, J; Soon, R; Tschann, M, 2022)
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."5.51The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Over a 12-month evaluation period, verbal numerical pain scores (VNPS) were gathered from adults with moderate to severe trauma pain attended by ambulance staff trained in administering and supplied with methoxyflurane."5.51Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study. ( Rowan, E; Siriwardena, AN; Smith, MD; Spaight, R, 2022)
"Intranasal fentanyl seems to be a safe and effective alternative to acetaminophen with hydrocodone in reducing pain and improving hydration status in children with painful infectious mouth lesions and poor oral intake."5.51Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions. ( Chen, JG; Cramm, K; Florez, C; Papa, L; Ramirez, J; Ruffin, TB; Salinero, E, 2022)
" The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography."5.51Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022)
" Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo."5.51Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study. ( Aktaş, N; Arslan, E; Aydın, İ; Gülaçtı, U; Sönmez, C; Turgut, K; Yavuz, E, 2022)
" IV and PO APAP doses administered with a predose pain score ≥4 within 1 h of dosing were compared."5.43Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. ( Brophy, GM; Nadpara, PA; Nichols, DC; Taylor, PD, 2016)
"Acetaminophen is a frequently used analgesic for pain and fever."5.41In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis. ( Albanese, CM; Barrett, K; Brown, HK; Fatima, M; Levis, B; Li, J; Pablo, LA; Ricci, C, 2023)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."5.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"The study aimed to compare the acetaminophen administration efficacy or its combination with codeine for pain control in acute apical abscesses cases."5.41Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial. ( Cardoso, MBF; da Rosa, RA; da Silva, PB; do Nascimento, AL; Mendes, AT; Pereira, JR; Só, MVR, 2021)
" The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)."5.41Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021)
" First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances."5.37Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011)
"Acetaminophen is an analgesic and antipyretic drug believed to exert its effect through interruption of nociceptive processing."5.35Acetaminophen prevents hyperalgesia in central pain cascade. ( Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL, 2008)
"Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline."5.35Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008)
" Lidocaine given intravenously has been shown in two small, uncontrolled studies to have an appreciable effect on pain after burns."5.34Lidocaine infusion has a 25% opioid-sparing effect on background pain after burns: A prospective, randomised, double-blind, controlled trial. ( Abdelrahman, I; Elmasry, M; Sjoberg, F; Steinvall, I, 2020)
"The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial."5.34Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020)
"The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of persons with dementia living in long-term care facilities (LTCFs)."5.34Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial. ( Achterberg, WP; Caljouw, MAA; Husebo, BS; van Dam, PH, 2020)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."5.34Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
"Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase."5.33Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice. ( Choi, SS; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW, 2005)
"To evaluate the effectiveness of verbal behavior modification, acetaminophen, and the combined effectiveness of verbal behavior modification along with acetaminophen on orthodontic pain."5.30A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. ( Abraham, R; Bansal, N; Kaur, H, 2019)
"We addressed these issues by investigating how acetaminophen administration and daily forgiveness are associated with experiences of social pain over 21 days."5.30Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen. ( Deal, BD; Gregory, A; Shields, GS; Slavich, GM; Toussaint, LL, 2019)
" Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups."5.30Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. ( Azami, A; Enteshari-Moghaddam, A; Habibzadeh, A; Isazadehfar, K; Jahanpanah, P; Mohebbi, H, 2019)
"To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection."5.30Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. ( Jongjidpranitarn, M; Nimmaanrat, S; Oofuvong, M; Prathep, S, 2019)
" Patients received stepwise pain treatment in which those who did not use analgesics were randomized to receive either paracetamol (3 g/day) or placebo tablets; those who already used pain treatment were allocated to buprenorphine transdermal system (max."5.27Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial. ( Bjorvatn, B; Blytt, KM; Flo, E; Husebo, B, 2018)
"There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED."5.27Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. ( Cattermole, GN; Graham, CA; Hung, KKC; Leung, LY; Leung, YK; Lo, RSL; Man, SY; Rainer, TH; Woo, WK, 2018)
"The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features."5.27Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018)
"To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department."5.27Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018)
" As part of an ongoing research program, we examined the effects of a commonly prescribed combination of medications for pain relief: alprazolam, a benzodiazepine, and a hydrocodone preparation, a combination opiate and acetaminophen, on a simulated driving protocol."5.27Evaluating drugged driving: Effects of exemplar pain and anxiety medications. ( Brown, TL; Gaffney, G; Milavetz, G; Spurgin, A, 2018)
"This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery."5.27Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. ( de Kam, ML; Groeneveld, GJ; Hay, JL; Siebenga, P; van Amerongen, G, 2018)
"The effects of acetaminophen and a reading task on physical pain tolerance and fearlessness about death were tested in 106 undergraduate students."5.27The Influence of Acetaminophen and Observational Conditioning on the Acquired Capability for Suicide. ( Chiurliza, B; Joiner, TE, 2018)
"An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain."5.24Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. ( Doherty, M; Hussain, S; McWilliams, D; Papou, A; Zhang, W, 2017)
" All studies analysed support that toxicity is not reached; and that acetaminophen provides a morphine sparing effect without adverse effects."5.22The efficacy and safety of acetaminophen use following liver resection: a systematic review. ( Koea, J; Murphy, V; Srinivasa, S, 2022)
"Buprenorphine formulations (including buprenorphine/naloxone) are effective treatments of pain and opioid use disorder (OUD)."5.22Perioperative Buprenorphine Management: A Multidisciplinary Approach. ( Abelleira, A; Acampora, G; Becker, WC; Falker, CG; Hickey, T; Nazario, M; Weimer, MB, 2022)
" Only one study found evidence of an effect between interventions on pain score: a prophylactic dose of ibuprofen 1600 mg likely reduces the pain score when compared to a dose of paracetamol 2000 mg (mean difference (MD) 2."5.22Pain management for medical abortion before 14 weeks' gestation. ( Cameron, S; Morroni, C; Reynolds-Wright, JJ; Woldetsadik, MA, 2022)
" Further research is required to determine whether the use of nitrous oxide has a role, and to develop a safe and effective analgesic strategy to fully ameliorate the pain of ROP screening."5.22Analgesia for retinopathy of prematurity screening: A systematic review. ( Hamilton, DL; Hassan, R; Savant, SV; Thirunavukarasu, AJ, 2022)
"Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants."5.22Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022)
"HNC patients (pts) receiving CRT were randomized to standard pain control (SPC) with acetaminophen and opioids, or SPC plus gabapentin (SPC+G)."5.22Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer. ( Chayahara, N; Fujiwara, Y; Funakoshi, Y; Kataoka, T; Kiyota, N; Komori, T; Minami, H; Mukohara, T; Nibu, K; Sasaki, R; Shimada, T; Toyoda, M, 2016)
"The combination of ibuprofen/paracetamol, taken immediately after initial endodontic therapy and root canal preparation in teeth with irreversible pulpitis, reduced post-endodontic pain (ClinicalTrials."5.22Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. ( Abubakr, NH; Elzaki, WM; Ibrahim, YE; Ziada, HM, 2016)
"The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator."5.22Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial. ( Ghadirian, H; Hosseinzadeh Nik, T; Ostad, SN; Shahsavari, N, 2016)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."5.22Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"Although liposomal bupivacaine had some effect on soft tissue anesthesia, it did not reduce pain to manageable clinical levels in patients presenting with untreated, symptomatic irreversible pulpitis."5.22Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( Beck, M; Bultema, K; Drum, M; Fowler, S; Nusstein, J; Reader, A, 2016)
" Significant reduction in pain intensity was observed with topical lidocaine group when compared with the ice application group (p < 0."5.20A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings. ( Aksel, G; Çorbacioğlu, ŞK; Doğan, NÖ; Güler, S, 2015)
"To evaluate the efficacy and safety profile of paracetamol in comparison with tramadol for pain relief during active labor."5.20Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor. ( Bhatia, N; Jain, K; Jain, V; Kaur Makkar, J; Mal Mithrawal, S, 2015)
"To test the analgesic efficacy of oxymorphone hydrochloride (OH) and propoxyphene/acetaminophen (PA) for patients with neurogenic claudication associated with lumbar spinal stenosis."5.20A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis. ( Chowdhry, AK; Dworkin, RH; Frazer, ME; Gewandter, JS; Markman, JD; McDermott, MP; Murray, NM; Pilcher, WH; Rast, SA; Tomkinson, EJ; Walter, KA, 2015)
"Acetaminophen, an effective and popular over-the-counter pain reliever (e."5.20Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli. ( Durso, GR; Luttrell, A; Way, BM, 2015)
"This study aims to evaluate and compare the effect of pre-procedural administration of acetaminophen, ibuprofen, and meloxicam in reducing pain after separator placement."5.20Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. ( Babanouri, N; Oshagh, M; Salehi, P; Torkan, S; Zarif Najafi, H, 2015)
"This randomized, double-blind study enrolled patients ≥40 years of age with confirmed hip or knee OA (Kellgren-Lawrence grade II-III) who were chronic users of NSAIDs and/or acetaminophen for OA pain and had Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale mean scores ≥40 mm."5.20Efficacy and safety of low-dose SoluMatrix meloxicam in the treatment of osteoarthritis pain: a 12-week, phase 3 study. ( Altman, R; Gibofsky, A; Hochberg, M; Jaros, M; Young, C, 2015)
"The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used."5.20Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015)
" According to a predefined scheme for 8 weeks, all patients in the intervention group received individual daily pain treatment with acetaminophen, extended release morphine, buprenorphine transdermal patch, and/or pregabaline."5.19The response of agitated behavior to pain management in persons with dementia. ( Aarsland, D; Ballard, C; Cohen-Mansfield, J; Husebo, BS; Seifert, R, 2014)
"The aim of this double-blind, randomized, placebo-controlled clinical study was to evaluate the analgesic effects of preoperative/postoperative ibuprofen and acetaminophen use after bonding and to find a relation between the pain level and the amount of prostaglandin released."5.19Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement. ( Bostanoglu, E; Demirbilek, M; Polat-Ozsoy, O; Tunçer, Z, 2014)
"9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0."5.19Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014)
"A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair."5.19Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014)
"This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)."5.19Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. ( Bijur, PE; Chang, AK; John Gallagher, E; Munjal, KG, 2014)
"This study aimed to evaluate whether combined oral oxycodone hydrochloride-controlled release tablets plus paracetamol and tramadol hydrochloride tablets are more effective than epidural analgesia for postoperative pain control and side effects after cesarean section."5.19A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia. ( Konstantatos, A; Liu, Q; Wang, HW; Zhao, JN; Zhong, TD, 2014)
" In a randomized controlled trial, we evaluated whether oral acetaminophen or ibuprofen reduced the pain experienced during pin removal."5.19Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial. ( Abdullah, SN; Allen, JC; Lim, KB; Ong, LL; Tan, SS; Wong, ML, 2014)
"Pain medication significantly improved pain in the intervention group, with indications that acetaminophen also improved ADL function."5.19Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014)
"Administration of 1 g paracetamol and 600 mg ibuprofen one hour prior to office hysteroscopy decreased statistically the occurrence of non-pain side effects such as nausea, emesis, and hypotension."5.19Evaluation of pain in office hysteroscopy with prior analgesic medication: a prospective randomized study. ( De Santiago, J; Teran-Alonso, MJ; Usandizaga, R; Zapardiel, I, 2014)
"Acetaminophen (APAP) by oral or intravenous (iv) routes is used for mild to moderate pain but may take time to be effective."5.19Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers. ( Cardot, JM; Coissard, S; Dubray, C; Libert, F; Macian, N; Maury, M; Perovitch, P; Pickering, G, 2014)
"Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain."5.19Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014)
"Rocuronium is a nondepolarizing neuromuscular blocking agent used in anesthesia induction and is associated with considerable discomfort and burning pain during injection, which is reported to occur in 50-80% of patients."5.19The effect of intravenous paracetamol for the prevention of rocuronium injection pain. ( Aypar, U; Canbay, O; Erden, IA; Uzun, S, 2014)
" We explore whether the neural mechanism that responds to meaning threats can be inhibited by acetaminophen, in the same way that acetaminophen inhibits physical pain or the distress caused by social rejection."5.17The common pain of surrealism and death: acetaminophen reduces compensatory affirmation following meaning threats. ( Heine, SJ; Randles, D; Santos, N, 2013)
" To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application."5.17Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013)
"Previous studies suggest that the antinociceptive action of paracetamol (acetaminophen, APAP) might involve descending inhibitory pain pathways and the opioidergic system: this study explores this issue in humans with naloxone, the opioid antagonist."5.17Paracetamol and opioid pathways: a pilot randomized clinical trial. ( Cardot, JM; Desbrandes, S; Dubray, C; Moustafa, F; Pickering, G; Roux, D, 2013)
"To assess the efficacy of paracetamol (acetaminophen) for neonatal pain relief."5.17Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response. ( Bucher, HU; Bührer, C; Burkhardt, T; Hoesli, I; Jost, K; Krafft, A; Nelle, M; Schöbi, N; Surbek, D; Tinner, EM; Ulrich Megged, Y, 2013)
"Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing."5.16Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012)
"5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) with that of nonsteroidal anti-inflammatory drugs (NSAIDs) as maintenance therapy following tramadol/APAP and NSAID combination therapy in knee osteoarthritis (OA) pain which was inadequately controlled by NSAIDs."5.16The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). ( Cho, CS; Choi, JJ; Kim, WU; Min, JK; Park, KS; Park, SH, 2012)
"The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease."5.15Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients. ( Kang, P; Li, J; Liu, G; Liu, W; Luo, R; Ma, X; Pei, F; Shen, B; Xie, Q; Zhou, Z, 2011)
"We tested whether paracetamol could improve pain relief in patients visiting the emergency department with acute renal colic as compared to piroxicam, a nonsteroidal anti-inflammatory drug (NSAID)."5.15Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial. ( Boubaker, H; Boudhib, L; Bouida, W; Boukef, R; Claessens, YE; Grissa, MH; Kerkeni, W; Nouira, S, 2011)
"Acetaminophen alone may not be as effective in reducing pain-related physiological and behavioral changes as acetaminophen plus codeine or ibuprofen plus midazolam during diagnostic tympanocentesis."5.15Pain management in young children undergoing diagnostic tympanocentesis. ( Chandra, A; Colborn, DK; Hoberman, A; Hooper, EG; Kurs-Lasky, M; Reis, EC; Rockette, HE; Shaikh, N, 2011)
"This double-blind, randomized controlled study evaluated etoricoxib (90 and 120 mg), ibuprofen (600 mg), and acetaminophen (600 mg/codeine) (60 mg, (A/C)) in patients aged ≥ 18 years with moderate or severe pain after surgical extraction of ≥ 2 third molars (≥ 1 impacted)."5.15Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. ( Bandy, DP; Boice, J; Christensen, SE; Daniels, SE; Liu, H; Losada, MC; Mehta, A; Peloso, PM, 2011)
"Our objective was too assess the effectiveness of 3 analgesics (ibuprofen, naproxen sodium, and acetaminophen) and a placebo administered before and after the placement of separators in reducing the severity of postseparator placement pain."5.15Effects of analgesics on orthodontic pain. ( Fillingim, R; Logan, H; McGorray, SP; Patel, S; Wheeler, TT; Yezierski, R, 2011)
"To evaluate the efficacy and safety of the paracetamol-tramadol combination (PTC) in treating moderate-to-severe pain, in patients aged 65 years and over within general practitioner (GP) practice centers."5.15Epidemiological data, efficacy and safety of a paracetamol-tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practice. ( Ganry, H; Mejjad, O; Serrie, A, 2011)
" The effects of acetaminophen, tropisetron, the combination of both drugs, and saline on pain perception and central sensitization in healthy volunteers were compared."5.15Tropisetron blocks analgesic action of acetaminophen: a human pain model study. ( Bandschapp, O; Filitz, J; Koppert, W; Ruppen, W; Urwyler, A, 2011)
"To assess the spontaneous passage rate for patients being treated with alfuzosin 10mg daily after presenting with an acute ureteral stone compared with a control group, and to assess the respective pain control status."5.15Medical expulsive therapy using alfuzosin for patient presenting with ureteral stone less than 10mm: a prospective randomized controlled trial. ( Chau, LH; Fan, CW; Fung, BT; Li, JC; Li, MK; Tai, DC, 2011)
" The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings."5.15A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011)
"Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis."5.15A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011)
"A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care."5.15A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011)
"The present study aimed to examine the effectiveness of intravenous administration of paracetamol added to morphine in the control of cancer pain and its possible contribution as reduction of opioid consumption and opioid-related side effects."5.14Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control. ( Aydinli, I; Keskinbora, K; Pekel, AF; Salihoglu, T; Sonsuz, A; Tasmacioglu, B, 2009)
"This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee."5.14Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa ( Berggren, AC; Karlsson, M, 2009)
"This study aims to evaluate the efficacy of methadone as substitute for morphine and to investigate if the addition of acetaminophen could reduce the time to attain an equianalgesic dose of methadone and/or to improve the level of pain control in oncologic patients."5.14Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study. ( Cubero, DI; del Giglio, A, 2010)
"To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)."5.14Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009)
"This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting."5.14Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. ( Friday, JH; Harley, JR; Kanegaye, JT; McCaslin, I; Zheng, A, 2009)
"We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)."5.14A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009)
"5 mg kg(-1) for prevention of propofol induced pain."5.14Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol. ( Borazan, H; Erdem, TB; Kececioglu, M; Otelcioglu, S, 2010)
"To establish whether acetaminophen improves performance of self-paced exercise through the reduction of perceived pain, 13 trained male cyclists performed a self-paced 10-mile (16."5.14Influence of acetaminophen on performance during time trial cycling. ( Jones, AM; Mauger, AR; Williams, CA, 2010)
"The adjunctive use of paracetamol (acetaminophen) with strong opioids has become entrenched practice in palliative care pain management, despite little evidence to support its use."5.14Lack of benefit from paracetamol (acetaminophen) for palliative cancer patients requiring high-dose strong opioids: a randomized, double-blind, placebo-controlled, crossover trial. ( Charles, M; Israel, FJ; Parker, G; Reymond, L, 2010)
"This novel OA pain model was able to discriminate both tramadol/acetaminophen and naproxen from placebo after single and multiple doses."5.14A walking model to assess the onset of analgesia in osteoarthritis knee pain. ( Beals, CR; Bolognese, JA; Harman, A; Kivitz, AJ; Moskowitz, RW; Peeva, E; Smugar, SS; Taber, L, 2010)
"This study suggests that paracetamol, lornoxicam, and tramadol can be safely and efficiently preferred in pain control during SWL."5.14Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol representing three different groups of analgesics for pain control in extracorporeal shockwave lithotripsy. ( Akcali, GE; Balcioglu, YO; Cam, K; Demiraran, Y; Iskender, A; Kayikci, A; Yalcin, GS, 2010)
" Results of this research showed the better efficacy of erythromycin in controlling effusion and pain with functional improvement in patients with knee effusion due to OA."5.14A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis. ( Ardalan, MR; Ghojazadeh, M; Molaeefard, M; Moloudi, R; Noshad, H; Sadreddini, S, 2009)
"Etodolac-paracetamol was significantly superior to etodolac alone in reducing pain intensity (P<0."5.14Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation. ( Ambade, R; Bartakke, G; Chandanwale, A; Chandurkar, N; Pareek, A, 2010)
"To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain."5.14Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010)
"Acetaminophen plus codeine is effective in pain control in polytrauma patients at least in our series."5.14Acetaminophen plus codeine compared to ketorolac in polytrauma patients. ( Buccelletti, F; Calcinaro, S; Carroccia, A; De Marco, G; Franceschi, F; Gentiloni Silveri, N; Giannuzzi, R; Gilardi, E; Giupponi, B; Mancini, F; Marini, M; Marsiliani, D; Merra, G; Potenza, A, 2010)
"This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy."5.14Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010)
"Subjects were randomized (3:3:1) to receive IV acetaminophen (1,000mg q6h or 650mg q4h) or standard-of-care treatment for pain or fever."5.14Safety of multiple-dose intravenous acetaminophen in adult inpatients. ( Bergese, SD; Candiotti, KA; Royal, MA; Singla, NK; Singla, SK; Viscusi, ER, 2010)
" They were randomized to receive ibuprofen or paracetamol when pain relief was necessary."5.14Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study. ( David, LB; Livshits, A; Machtinger, R; Moshe-Zahav, A; Seidman, DS; Spira, M, 2009)
" Aim of this study was to examine the analgesic and antihyperalgesic properties of the weak opioid tramadol and the non-opioid acetaminophen, alone as well as in combination, in an experimental pain model in humans."5.13Supra-additive effects of tramadol and acetaminophen in a human pain model. ( Filitz, J; Günther, W; Ihmsen, H; Koppert, W; Schüttler, J; Schwilden, H; Tröster, A, 2008)
" acetaminophen seems to be effective in attenuating pain during i."5.13Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain. ( Arun, O; Canbay, O; Celebi, N; Karagöz, AH; Ozgen, S; Saricaoğlu, F, 2008)
"Acetaminophen 650 mg or ibuprofen 400 mg taken 1 hour prior to separator placement can reduce pain associated with the procedure."5.12Pharmacological Means of Pain Control during Separator Placement: A Systematic Review. ( Arishi, SA; Ghazwani, LY; Ghoussoub, MS; Jafer, MA; Patil, S; Sharawi, NA; Somaili, AMH; Somaili, RM; Sumayli, AH; Sumayli, MA, 2021)
"Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever."5.12Paracetamol: unconventional uses of a well-known drug. ( Bloukh, S; Matheson, C; Wazaify, M, 2021)
"The analgesic effect of acetaminophen/placebo (expressed as the area under the curve of the percentage of the individual pain score reported at baseline along time [% x min]) (2145 +/- 2901 % x min) was totally inhibited by both tropisetron (89 +/- 1747 % x min, P = ."5.12Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. ( Beaune, P; Dubray, C; Eschalier, A; Libert, F; Loriot, MA; Pickering, G, 2006)
"To examine, in routine practice, the effectiveness and cost-effectiveness of oxycodone (OxyContin) compared with standard therapy for osteoarthritis pain."5.12Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee. ( Buitendyk, M; Codding, C; Marshall, DA; Pericak, D; Strauss, ME; Torrance, GW, 2006)
"In this double-blind cross-over study, we assessed whether erythromycin infusion is effective as a prokinetic drug against gastroparesis from acute pain."5.12Erythromycin promotes gastric emptying during acute pain in volunteers. ( Allaouchiche, B; Bleyzac, N; Boselli, E; Bouvet, L; Chassard, D; Duflo, F; Mion, F, 2006)
"Administering 75 mg tramadol/650 mg acetaminophen orally with periprostatic 1% lidocaine before transrectal ultrasound guided prostate biopsy is a safe, easy and effective method of controlling pain during the biopsy procedure."5.12Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial. ( Carvin, DM; Costa, J; Pendleton, J; Rosser, CJ; Wludyka, P, 2006)
"The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC)."5.12Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. ( Bey, M; Burnett, I; Grattan, T; Littlejohn, S; Sanner, K; Schachtel, B, 2006)
"0001) and was superior to pseudoephedrine and placebo for pain relief (p < or = 0."5.12Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. ( Burnett, I; Eccles, R; Jawad, M; Jawad, S; Jones, E; North, M; Ridge, D, 2006)
"5-mg/acetaminophen 325-mg combination tablets (tramadoUAPAP) as add-on therapy in subjects with rheumatoid arthritis (RA) pain that was inadequately controlled by NSAIDs and disease-modifying antirheumatic drugs alone."5.12Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial. ( Baek, HJ; Kim, HA; Lee, CK; Lee, EB; Lee, EY; Lim, MK; Park, BJ; Seo, YI; Sheen, DH; Shim, SC; Song, YW; Yoo, B, 2006)
"Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries."5.12A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007)
"The aim of this study was to determine the analgesic effect of acetaminophen compared to a combination of both caffeine and acetaminophen or caffeine alone using tonic and phasic pain stimulation."5.12Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. ( Beisel, A; Brune, K; Clarke, G; Grattan, T; Kobal, G; Mueller, C; Renner, B; Werner, U, 2007)
"Patients (N = 77, aged 8-14 y, 61% male) with ankle injuries presenting to a regional pediatric emergency department were assigned to receive either acetaminophen (15 mg/kg 4 times a day) or naproxen (5 mg/kg 4 times a day) in a double-blind fashion on a routine basis for a 5 day period."5.12Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children. ( Cukiernik, VA; Lim, R; Matsui, D; Rieder, MJ; Seabrook, JA; Warren, D, 2007)
"Combined tramadol/acetaminophen is used to treat pain related to osteoarthritis."5.12A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain. ( Bae, SC; Choe, JY; Choi, CB; Chung, WT; Hong, YH; Ji, JD; Kang, YM; Kim, HA; Kim, TH; Lee, CK; Lee, J; Lee, JT; Lim, MK; Nam, EJ; Park, SH; Seo, YI; Sheen, DH; Shim, SC; Song, GG; Song, JS; Suh, CH; Sung, YK, 2007)
" The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments."5.12Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. ( Bhasale, S; Deo, N; Gala, J; Mehta, K; Miller, MJ; Modak, M; Naik, S; Thakur, H, 2007)
"This study compared the efficacy and safety profile of buprenorphine transdermal delivery system (BTDS) and placebo in subjects with persistent noncancer-related pain who required opioid analgesics."5.12Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study. ( Carr, WD; Landau, CJ; Munera, C; Razzetti, AJ; Ripa, SR; Sessler, NE, 2007)
"It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries."5.12The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium. ( Agus, H; Kayali, C; Surer, L; Turgut, A, 2007)
"5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)."5.11Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004)
"5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients."5.11Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004)
"To compare the effects of providing analgesia with either transdermal fentanyl (TTS-fentanyl) or paracetamol and codeine (P/C) in addition to radiotherapy in patients with metastatic bone pain."5.11Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. ( Eleftheriadis, N; Georgakopoulos, G; Gompakis, N; Kouloulias, VE; Kouvaris, J; Mystakidou, K; Pistevou-Gompaki, K; Varveris, C, 2004)
"This study clearly showed the efficacy of a short course of oral prednisone (3 days), versus a placebo, in the treatment of the functional signs of acute maxillary rhinosinusitis with severe pain in adults in addition to an appropriate antibiotic treatment."5.11[Treatment of functional signs of acute maxillary rhinosinusitis in adults. Efficacy and tolerance of administration of oral prednisone for 3 days]. ( Bordure, P; Coriat, F; Deslandes, B; Desmonts-Gohler, C; Dubreuil, C; Gehanno, P; Gilain, L; Jankowski, R; Klossek, JM; Serrano, E; Stoll, D, 2004)
"In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of >or= 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (singledose phase) followed by 5/325 mg every 6h as needed (multidose phase), or placebo."5.11Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. ( Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA, 2004)
"To determine in a sample of nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of acetaminophen in reducing discomfort."5.11A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia. ( Brod, M; Buffum, MD; Miaskowski, C; Sands, L; Washburn, A, 2004)
"To determine whether adding regular acetaminophen (paracetamol) could improve pain and well-being in people with advanced cancer and pain despite strong opioids."5.11Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial. ( Pillai, A; Stockler, M; Vardy, J; Warr, D, 2004)
"Subjects with moderate or greater wrist pain were randomized and stratified to 1 of the following treatments: efficacy evaluation (heat wrap, n=39; oral placebo, n=42) or blinding (oral acetaminophen, n=6; unheated wrap, n=6)."5.11Continuous low-level heat wrap therapy is effective for treating wrist pain. ( Erasala, GN; Hengehold, DA; Hun, L; Michlovitz, S; Weingand, KW, 2004)
"It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of nasal congestion associated with the common cold."5.11Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold. ( Loose, I; Winkel, M, 2004)
"To compare the safety and efficacy of a new cyclooxygenase-2 inhibitor, valdecoxib, with those of an oxycodone-acetaminophen combination in patients with acute musculoskeletal pain."5.11Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. ( Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A, 2004)
"Patients with mild to moderate pain were randomised to either: paracetamol up to 3 g/d, aspirin up to 3 g/d or ibuprofen up to 1200 mg/d for 7 days."5.11A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data. ( Jones, JK; Moore, N; Parc, JM; Schneid, H; Van Ganse, E; Wall, R, 2005)
"To compare efficacy and safety of strepfen (flurbiprofen) to those of oral paracetamol in acute infections of the upper respiratory tracts for relief of throat pain (TP)."5.11[Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain]. ( Balandin, AV; Dimova, AD; Sedinkin, AA, 2005)
"To compare the analgesic effect of single doses of etoricoxib 120 mg, oxycodone/ acetaminophen 10 mg/650 mg and codeine/ acetaminophen 60 mg/600 mg in acute pain using the dental impaction model."5.11The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain. ( Ang, J; Fricke, JR; Malmstrom, K; Reicin, A; Shingo, S, 2005)
"There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone."5.11Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005)
"The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea."5.10Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002)
"2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815)."5.10Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. ( Cairns, R; Le Parc, JM; Moore, N; Schneid, H; van Ganse, E; Wall, R, 2002)
"The objectives of this study were to compare the incidence, onset, duration and pain scores of transient neurologic symptoms (TNS) with 1% versus 5% hyperbaric lidocaine in spinal anesthesia for short urological procedures in a large prospective study."5.10Prospective study on incidence and functional impact of transient neurologic symptoms associated with 1% versus 5% hyperbaric lidocaine in short urologic procedures. ( Bremang, J; Chung, F; Friedlander, M; Mezei, G; Streiner, D; Tong, D; Wong, J, 2003)
"5 mg tramadol/325 mg acetaminophen) for the treatment of fibromyalgia pain."5.10Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study. ( Bennett, RM; Kamin, M; Karim, R; Rosenthal, N, 2003)
"The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain."5.10Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002)
"Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol."5.09Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol. ( Bhagat, K; Lala, I; Leech, P; Montgomery, L, 2000)
"To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain."5.09Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999)
"In this prospective clinical trial, term neonates wtih painful conditions or who were undergoing painful procedures received multiple-dose acetaminophen."5.09Multiple-dose pharmacokinetics of rectally administered acetaminophen in term infants. ( Deinum, HT; Okken, A; Quak, CM; Tibboel, D; van Lingen, RA, 1999)
"This randomized, double-blind, placebo-controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg--an effervescent solution and tablet--in 242 patients with moderate or severe pain following dental surgery."5.09Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. ( Ganry, HE; Insuasty, JH; Møller, PL; Nørholt, SE; Sindet-Pedersen, S; Skoglund, LA; Vincent, FG, 2000)
"Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers."5.09Combined analgesia and local anesthesia to minimize pain during circumcision. ( Gilbert-MacLeod, C; Koren, G; Ohlsson, K; Pollock, N; Taddio, A, 2000)
"5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain."5.09Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000)
"To determine whether greater pain intensity at initiation of treatment predicted better response to ibuprofen than to acetaminophen in subjects with knee osteoarthritis (OA)."5.09Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001)
"Opioid/acetaminophen (APAP) combination analgesics are widely prescribed for the relief of moderate pain."5.09Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. ( Lacy, JR; Mullican, WS, 2001)
"Ibuprofen and acetaminophen with codeine had similar analgesic properties in the first 24 hours post partum (mean pain rating 3."5.09Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. ( Douglas, MJ; Grange, CS; Janssen, PA; Peter, EA, 2001)
"The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia."5.08Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998)
"To evaluate the efficacy of an oral tramadol preparation versus that of an oral hydrocodone-acetaminophen preparation in acute musculoskeletal pain."5.08Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. ( Larkin, GL; Paris, PM; Turturro, MA, 1998)
" Acetaminophen and meperidine were given for postoperative pain."5.07Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994)
"Lysine clonixinate (LC), an effective and well tolerated non-morphinic analgesic whose mechanism of action is basically due to the inhibition of cyclo-oxygenase, was assessed with a double-blind randomized dummy design versus paracetamol (P) on 200 patients suffering from pain after minor dental surgery."5.07Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol. ( De los Santos, AR; Di Girolamo, G; Fraga, C; Gil, M; Manero, EO; Martí, ML, 1993)
"Recognizing the concerns about the use of local anesthesia in neonatal circumcision, a painful procedure usually performed without analgesia or anesthesia, we undertook a study of acetaminophen for pain management of this procedure."5.07Acetaminophen analgesia in neonatal circumcision: the effect on pain. ( Howard, CR; Howard, FM; Weitzman, ML, 1994)
"The full dose of acetaminophen significantly reduced the incidence of sore arm and nausea without affecting the antibody response."5.07Effects of acetaminophen on adverse effects of influenza vaccination in health care workers. ( Aoki, FY; Cheang, M; Hammond, GW; Murdzak, C; Seklà, LH; Wright, B; Yassi, A, 1993)
"In a double-blind study of 18 patients with coxarthrosis the effect of 3 naproxen doses (0."5.07Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients. ( Neander, G; Samuelson, P; Seideman, P, 1993)
"At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy."5.07Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993)
"To assess the sore throat pain model in children as an assay for systemic analgesic agents in children under double-blind, placebo-controlled conditions, we conducted a single-dose parallel study that compared 10 mg/kg ibuprofen (n = 39), a new analgesic agent for children, and 15 mg/kg acetaminophen (n = 38), an approved analgesic for children, to placebo (n = 39) in children from 2 to 12 years of age with acute sore throat."5.07A placebo-controlled model for assaying systemic analgesics in children. ( Schachtel, BP; Thoden, WR, 1993)
"Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers."5.07Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity. ( Bromm, B; Forth, W; Richter, E; Scharein, E, 1992)
"In a randomized, double-blind prospective manner, patients received either 5 mg hydrocodone with 500 mg acetaminophen or 30 mg codeine with 500 mg acetaminophen to take on discharge from the ED and every four hours thereafter as needed for pain."5.07Hydrocodone versus codeine in acute musculoskeletal pain. ( Menegazzi, JJ; Paris, PM; Turturro, MA; Yealy, DM, 1991)
"In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day."5.07Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991)
"In a double-blind, placebo-controlled study the efficacy and safety of topical ketorolac tromethamine were assessed in the reduction of inflammation and pain due to ankle sprain."5.06A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate. ( Bullingham, R; Diebschlag, W; Nocker, W, 1990)
"This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip."5.06Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990)
"The analgesic efficacy of acetaminophen sustained release (SR) and acetaminophen immediate plus sustained release (IR + SR) was evaluated in 200 outpatients with pain after oral surgery."5.06Analgesic efficacy of acetaminophen sustained release. ( Engevall, S; Forsberg, O; Larsson, O; Quiding, H; Ström, C, 1990)
"Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control."5.06The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988)
" Eight hundred and forty-six patients with pain in one or two joints of the hip, knee, ankle or wrist participated in a randomised double-blind trial to compare the efficacy, tolerability and effect on quality of life of diclofenac sodium slow release (DSR) 100 mg daily and a combination of dextropropoxyphene 180 mg and paracetamol 1."5.06Joint pain and quality of life; results of a randomised trial. ( Bulpitt, CJ; Darekar, B; Fletcher, A; Parr, G, 1989)
"We compared naproxen sodium (550 mg) and propoxyphene napsylate with acetaminophen (PN/A, 100 mg with 650 mg) for pain relief after arthroscopy or arthroscopic meniscectomy."5.06Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen. ( Drez, D; Ritter, M; Rosenberg, TD, 1987)
"A double-blind multicenter cross-over study was conducted on 166 outpatients with painful chronic osteoarthritis of the hip and of the femoro-tibial joints, to compare the effectiveness of glafenine and paracetamol."5.06A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach. ( Amor, B; Benarrosh, C, 1988)
" The second study compared three weeks of treatment with daily doses of 200 mg of flurbiprofen and 4 g of acetaminophen in 50 patients with acute low back pain."5.06Flurbiprofen for the treatment of soft tissue trauma. ( Muckle, DS, 1986)
"To test the hypothesis that the postoperative abdominal pain of tubal occlusion is mediated by prostaglandins, the effects of meclofenamate, a potent inhibitor of cyclooxygenase, on postoperative analgesia and incidence of abdominal pain were compared with those of acetaminophen, a weak inhibitor of prostaglandin activity."5.06Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion. ( Caissie, KF; Huang, KC; Simpson, PM; Tsueda, K; Wolfe, WM, 1986)
" Patients with tonsillopharyngitis randomly received either 400 mg ibuprofen (n = 39), 1000 mg acetaminophen (n = 40), or placebo (n = 41)."5.06Sore throat pain in the evaluation of mild analgesics. ( Baybutt, RI; Fillingim, JM; Lane, AC; Schachtel, BP; Thoden, WR, 1988)
"Fifty college athletes with acute sprains and strains from football-related activities were randomly assigned to treatment with either diflunisal or acetaminophen with codeine for seven days."5.06Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. ( Indelicato, PA, 1986)
"Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children."5.05Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020)
"The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study."5.05Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984)
"The efficacy and acceptability of meptazinol and dextropropoxyphene plus paracetamol were compared in 32 elderly patients with various types of musculoskeletal pain."5.05A comparison between meptazinol and dextropropoxyphene plus paracetamol in elderly patients with musculoskeletal pains. ( Orö, L, 1984)
"Twenty-five patients suffering from primary dysmenorrhoea took part in a double-blind crossover study which demonstrated flurbiprofen (100 mg three times a day) to be significantly more effective than paracetamol (1 g three times a day) in providing pain relief on Days 1 and 2, and on the worst day of pain."5.05A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea. ( Maclean, D, 1983)
"In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)."5.05A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984)
"The clinical efficacy and tolerability of a combination preparation ('Norgesic') of 35 mg orphenadrine plus 450 mg paracetamol was compared with that of placebo in a controlled double-blind, parallel group, 7-day study comprising 44 patients suffering from pain due to tension of the cervical and upper thoracic musculature."5.05Effect of a combination of orphenadrine/paracetamol tablets ('Norgesic') on myalgia: a double-blind comparison with placebo in general practice. ( Høivik, HO; Moe, N, 1983)
"In a double-blind cross-over trial of azapropazone and indomethacin in 20 patients with osteoarthritis of the hip and knee with four weeks on each drug, three methods of assessing pain and pain relief were used."5.05A comparison of three ways of measuring pain. ( Frank, AJ; Hort, JF; Moll, JM, 1982)
"A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo."5.05A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982)
"A double-blind study was carried out in 48 patients with soft-tissue injuries to compare the effectiveness of mefenamic acid and dextropropoxyphene plus paracetamol in relieving acute post-injury pain."5.04Mefenamic acid and dextropropoxyphene with paracetamol as analgesics in the accident department. ( Stableforth, PG, 1977)
"A preliminary double-blind, randomized trial was carried out in general practice to compare the efficacy of treatment with diflunisal (500 mg) twice daily and a combination of dextropropoxyphene (65 mg) plus paracetemol (650 mg) 3-times daily for 3 days in relieving pain associated with strains and sprains."5.04A controlled study of diflunisal in sprains and strains. ( Grimshaw, JJ; Jaffé, GV; Roylance, PJ, 1978)
"Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis."5.04A clinical Trial of Tofranil in osteo-arthritis. ( Glick, EN, 1976)
"Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics--floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine--were compared."5.04A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice. ( Gay, J; Lomas, DM; Midha, RN; Postlethwaite, DL, 1976)
"This article reviews the mechanisms of action, clinical use, and recent scientific evidence for the use of nonsteroidal antiinflammatory drugs, grapiprant, acetaminophen (paracetamol), metamizole (dipyrone), and corticosteroids in pain management."5.01Antiinflammatory Drugs. ( Monteiro, B; Steagall, PV, 2019)
" Mean pain scores were: opioids ± NSAIDs ± acetaminophen (4."5.01Pain Management Protocols During Uterine Fibroid Embolisation: A Systematic Review of the Evidence. ( Anthony, S; Elzein, A; Husainy, MA; Makris, GC; Patel, R; Saibudeen, A; Uberoi, R; Wigham, A, 2019)
"With respect to analgesics use, we employed data from national registries on the analgesic prescription use (opioids, nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen) in 2017 among elderly people with and without dementia."5.01Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review. ( Bandak, E; Christensen, MB; Johannsen, P; Kallehauge, H; Lolk, A; Pedersen, H; Saxtrup, N; Solem, EJ; Sørensen, AMS; Tarp, S, 2019)
"- Paracetamol or ibuprofen should only be given when there is a combination of fever and pain."4.95[Revision of the Dutch College of General Practitioners practice guideline 'Children with fever']. ( Eizenga, WE; Opstelten, W, 2017)
"Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a focused analysis."4.95Perinatal and neonatal use of paracetamol for pain relief. ( Allegaert, K; van den Anker, JN, 2017)
"Based on a PubMed database literature search on the terms efficacy, safety, paracetamol, acetaminophen, codeine and their combinations up to and including June 2016, this clinical update reviews the current evidence of the benefit and risks of oral paracetamol alone and with codeine for mild-to-moderate pain in adults, and compares the respective efficacy and safety profiles with those of nonsteroidal anti-inflammatory drugs (NSAIDs)."4.95Clinical update on benefit versus risks of oral paracetamol alone or with codeine: still a good option? ( Kress, HG; Untersteiner, G, 2017)
"The objectives of this review were to assess the ability of both pharmacological and non-pharmacological interventions to reduce or eliminate the pain that accompanies rocuronium bromide administration."4.93Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. ( Ali, Z; Kalaivani, M; Prabhakar, H; Singh, GP; Smith, MA, 2016)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."4.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
" All treatments except acetaminophen showed clinically significant improvement from baseline pain."4.91Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. ( Bannuru, RR; Kent, DM; McAlindon, TE; Schmid, CH; Vaysbrot, EE; Wong, JB, 2015)
"Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever in children."4.90Paracetamol: a focus for the general pediatrician. ( Barbi, E; Guarino, S; Marzuillo, P, 2014)
"To determine the efficacy and safety of codeine used alone or in combination with paracetamol for relieving cancer pain."4.90Codeine, alone and with paracetamol (acetaminophen), for cancer pain. ( Bell, RF; Derry, S; Jackson, KC; Strassels, S; Straube, C; Straube, S; Wiffen, PJ, 2014)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."4.89Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013)
"Acetaminophen/codeine combination is effective in the treatment of moderate to severe pain in all setting analyzed in this study, which include headache, postoperative, osteoarticular and post-traumatic."4.89Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin. ( Alesi, A; Antonini, EF; Cordischi, C; Franceschi, F; Giacobelli, D; Iacomini, P; Marsiliani, D; Zuccalà, G, 2013)
" In paediatric populations, ibuprofen and paracetamol (acetaminophen) are both commonly used over-the-counter medicines for the management of fever or mild-to-moderate pain associated with sore throat, otitis media, toothache, earache and headache."4.89Optimising the management of fever and pain in children. ( van den Anker, JN, 2013)
"To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness."4.88Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012)
"To systematically review the literature on the efficacy and safety of paracetamol (acetaminophen) in the management of pain in inflammatory arthritis."4.88Paracetamol for the management of pain in inflammatory arthritis: a systematic literature review. ( Bombardier, C; Hazlewood, G; van der Heijde, DM, 2012)
"To systematically review the literature on the safety of using nonsteroidal antiinflammatory drugs (NSAID) and/or paracetamol in people receiving methotrexate (MTX) for inflammatory arthritis (IA), as an evidence base for generating clinical practice recommendations."4.88Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review. ( Colebatch, AN; Edwards, CJ; Marks, JL; van der Heijde, DM, 2012)
"Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited."4.87Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011)
"Ibuprofen is as or more efficacious than acetaminophen for the treatment of pain and fever in adult and pediatric populations and is equally safe."4.86Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. ( Pierce, CA; Voss, B, 2010)
"Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain."4.86Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010)
"To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions."4.86A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine. ( Day, R; Graham, G; Palmer, H; Williams, K, 2010)
"Intravenous paracetamol (rINN)/intravenous acetaminophen (USAN) is an analgesic and antipyretic agent, recommended worldwide as a first-line agent for the treatment of pain and fever in adults and children."4.85Intravenous paracetamol (acetaminophen). ( Duggan, ST; Scott, LJ, 2009)
"To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain."4.84Effectiveness of oral vs rectal acetaminophen: a meta-analysis. ( Berkovitch, M; Berlin, M; Goldstein, LH; Kozer, E, 2008)
"Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage."4.84Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007)
"To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen."4.84COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008)
" Pharmacologic approaches to pain treatment include acetaminophen, anti-inflammatory agents, opiates, and bisphosphonates."4.83Cancer-related pain and its pharmacologic management in the patient with bone metastasis. ( Slatkin, N, 2006)
"Nonopioid analgesics, which include acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2)-specific inhibitors (coxibs), are frequently used for the relief of mild-to-moderate pain."4.83Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. ( Whelton, A, 2006)
"Data supporting the rationale of combining tramadol and acetaminophen to provide pain relief will be reviewed in addition to clinical data demonstrating the efficacy and safety of this combination in acute and chronic pain states."4.82The new analgesic combination tramadol/acetaminophen. ( Schnitzer, T, 2003)
"Paracetamol (acetaminophen) has been shown to be an effective analgesic for the treatment of moderate pain where it is chiefly indicated, as shown in placebo-controlled studies in the perioperative setting and other acute pain states."4.82[Role of paracetamol in the acute pain management]. ( Kehlet, H; Werner, MU, 2003)
"To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever."4.82Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004)
"To assess the efficiency of paracetamol, indicated in first instance for light-to-moderate pain from hip and knee arthrosis, against rofecoxib, the COX-2 inhibitor most commonly used in Spain."4.82[Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip]. ( Lizán Tudela, L; Magaz Marqués, S; Riesgo Bucher, Y; Varela Moreno, C, 2004)
"The treatment of acute or chronic pain of variable intensity and origin, is efficiently achieved by the association of paracetamol and codeine."4.81[Efficacy and safety of acetaminophen-codeine in the treatment of pain]. ( Hantson, P, 2002)
"Paracetamol (acetaminophen) has a unique role in children because it is the first-line choice for the treatment of both fever and pain."4.80Paracetamol efficacy and safety in children: the first 40 years. ( Coghlan, D; Cranswick, N, 2000)
"Paracetamol (acetaminophen) is one of the most widely used of all drugs, with a wealth of experience clearly establishing it as the standard antipyretic and analgesic for mild to moderate pain states."4.80Paracetamol: past, present, and future. ( Prescott, LF, 2000)
"Injections of diclofenac induced antinociception in visceral pain models (writhing test, colorectal distension test), but not in two models of somatosensory pain (tail-flick and hot-plate test)."4.79Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. ( Björkman, R, 1995)
" Pooled efficacy results indicated that codeine added to paracetamol provided a 5% increase in analgesia on the sum pain intensity difference."4.79Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review. ( de Craen, AJ; Di Giulio, G; Kessels, AG; Kleijnen, J; Lampe-Schoenmaeckers, JE, 1996)
"In order to assess the analgesia obtained from single oral doses of paracetamol alone and in combination with codeine in postoperative pain, we conducted a systematic review of randomised controlled trials."4.79Paracetamol with and without codeine in acute pain: a quantitative systematic review. ( Carroll, D; Collins, S; McQuay, H; Moore, A, 1997)
"Paracetamol, codeine, and tramadol are commonly used to manage mild pain, and their availability without prescription or medical consultation raises concerns about potential opioid addiction."4.31Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study. ( Alvarez-Mon, M; Alvarez-Mon, MA; Carabot, F; Donat-Vargas, C; Fraile-Martínez, O; García-Montero, C; Monserrat, J; Ortega, MA; Santoma-Vilaclara, J; Zaragoza, C, 2023)
"A prediction model development study was completed using the 2006 American Migraine Prevalence and Prevention Study survey, from participants who were aged ≥18, met criteria and headache day frequency for episodic migraine, did not take prescription medication for migraine, and used ≥1 of the following acute migraine medication classes: acetaminophen, aspirin, NSAIDs, or caffeine containing combination products (CCP)."4.12Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. ( Armand, CE; Buse, DC; Ezzati, A; Fanning, KM; Lipton, RB; Martin, VT; Pavlovic, JM; Reed, ML, 2022)
" PPS was associated with reduced pain as well as a reduction in paracetamol and morphine use."4.12Immediate full weight bearing after pelvic percutaneous fixation by screw for simple acetabular and pelvic ring fractures in patients older than sixty five years. ( Benhenneda, R; Di Francia, R; Dubrana, F; Letissier, H, 2022)
"Acetaminophen is widely used to treat mild to moderate pain and to reduce fever."4.12Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection. ( Han, J; Li, W; Zhang, X, 2022)
"Overall, 74% of women reported acetaminophen use during pregnancy."4.12Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes. ( Bandoli, G; Chambers, C; Killion, JA; Smith, CJF, 2022)
"Paracetamol, one of the most widely used pain-relieving drugs, is deacetylated to 4-aminophenol (4-AP) that undergoes fatty acid amide hydrolase (FAAH)-dependent biotransformation into N-arachidonoylphenolamine (AM404), which mediates TRPV1-dependent antinociception in the brain of rodents."4.02Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity. ( Å Nilsson, JL; Blomgren, A; Blomqvist, A; Boudieu, L; Eschalier, A; Grundemar, L; Mallet, C; Nilsson, UJ; Shionoya, K; Sundin, AP; Zygmunt, PM, 2021)
"The inclusion of IV acetaminophen as part of a multimodal pain regimen led to fewer episodes of delirium in this study."3.96Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients. ( Connolly, KP; Kleinman, RS; Mehta, SN; Neuman, MD; Stevenson, KL, 2020)
"Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy."3.96Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. ( Bandoli, G; Chambers, C; Palmsten, K, 2020)
"ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan."3.96Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception. ( Micov, A; Pecikoza, U; Stepanović-Petrović, R; Tomić, M; Vuković, M, 2020)
"Paclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment."3.96Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats. ( Brusco, I; Ferreira, J; Hausen, BDS; Moresco, RN; Oliveira, SM; Pinheiro, KV; Rigo, FK, 2020)
" Pain medication consisted of ibuprofen 600 mg and paracetamol 1000 mg, first doses taken simultaneously with misoprostol and repeated, if needed, up to three times daily."3.96Pain during medical abortion in early pregnancy in teenage and adult women. ( Heikinheimo, O; Kemppainen, V; Mentula, M; Palkama, V, 2020)
"Paracetamol (acetaminophen) is widely used for management of mild-to-moderate pain and reduction of fever."3.91Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol. ( Dosenovic, S; Margan Koletic, Z; Puljak, L, 2019)
" Analgesics were coded as any pain medication, counts (total analgesics, number of opioids and nonopioids), equianalgesics (oral morphine equivalents, oral acetaminophen equivalents), and dose categories."3.91Analyzing Analgesic Medications in Community-Dwelling Older Adults. ( Farland, MZ; Horgas, AL; Marsiske, M; Snigurska, U, 2019)
"Acetaminophen has long been assumed to selectively alleviate physical pain, but recent research has started to reveal its broader psychological effects."3.91Acetaminophen influences social and economic trust. ( Krajbich, I; Roberts, ID; Way, BM, 2019)
" To assess the usefulness of this model for testing potential analgesics, three known synthetic pain medications were assessed (ibuprofen, acetaminophen and tramadol) along with three naturally occurring products (honokiol, tetrahydrocannabinol and cannabidiol)."3.88Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. ( Achenbach, JC; Berrue, F; Ellis, LD; Hill, J; McDougall, JJ; Morash, M, 2018)
" tramadol, codeine, or opium-containing drugs, or by PC for a weak level of pain."3.88Use of analgesics in France, following dextropropoxyphene withdrawal. ( Aubrun, F; Belhassen, M; Chrétien, E; Cornu, C; Ecoffey, C; Ginoux, M; Van Ganse, E, 2018)
"There are contrasting positions concerning the benefit-risk ratio of acetaminophen use for osteoarthritis (OA)-related pain."3.85Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care. ( Cricelli, C; Cricelli, I; Fanelli, A; Fornasari, D; Lapi, F; Lombardi, N; Lora Aprile, P; Simonetti, M; Vannacci, A, 2017)
"About a year after dextropropoxyphene (DXP) withdrawal from the French market, we conducted a survey among members of the French Society of Anesthesia & Intensive Care Medicine (Sfar) and of the French Society of the Study and Treatment of Pain (SFETD) to identify the indications for which this WHO level II analgesic had been prescribed, the prescriber's feedback following withdrawal, and the substitutive analgesics prescribed."3.85What are the therapeutic alternatives to dextropropoxyphene in France? A prescribers' survey. ( Aubrun, F; Belhassen, M; Beloeil, H; Chrétien, E; Ginoux, M; Lanteri-Minet, M; Letrilliart, L; Van Ganse, E, 2017)
"Women who used naproxen or opioids had slightly lower fecundability than women who did not use any pain-relieving medications; use of acetaminophen, aspirin and ibuprofen was not appreciably associated with fecundability."3.85Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study. ( Hatch, EE; McInerney, KA; Mikkelsen, EM; Rothman, KJ; Wesselink, AK; Wise, LA, 2017)
"Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain."3.85Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017)
"This study was designed to formulate a drug in adhesive transdermal patch with codeine (CDB) and acetaminophen (APAP) that may potentially treat moderate pain in children."3.83Formulation optimization of a drug in adhesive transdermal analgesic patch. ( Abla, MJ; Banga, AK; Herwadkar, AK; Little, J; Ravula, R, 2016)
"Data of patients treated with a combination of oxycodone (5, 10, and 20 mg) and acetaminophen (325 mg) were evaluated for gender, current disease condition, basal pain intensity, total daily dose, days of controlled pain at the initial low dose, and pain intensity after treatment using a numeric pain rating scale."3.83Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better. ( Carpenedo, R; Dauri, M; Lazzari, M; Mammucari, M; Natoli, S; Palombo, E; Silvi, MB, 2016)
"Although most patients were prescribed IR hydrocodone/acetaminophen for acute pain, the number of patients prescribed long-term therapy exceeds the number of patients prescribed ER opioids."3.81A retrospective cohort study of long-term immediate-release hydrocodone/acetaminophen use and acetaminophen dosing above the Food and Drug Administration recommended maximum daily limit among commercially insured individuals in the United States (2008-201 ( Alexander, L; Chilcoat, H; Coplan, P; DeVeaugh-Geiss, A; Kadakia, A, 2015)
" These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain."3.80Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014)
"The primary objective was to assess whether patients with a fever are treated with acetaminophen or ibuprofen more promptly than they are treated for pain."3.80Is fever treated more promptly than pain in the pediatric emergency department? ( Bair, J; Dvorkin, R; Glantz, S; Marguilies, J; Patel, H; Rosalia, A; Yens, DP, 2014)
"Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking."3.80Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014)
" In the writhing test, pain responses were scored every 5 min during a 30-min period after intraperitoneal injection of diluted acetic acid."3.80Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. ( Lupusoru, CE; Lupusoru, RV; Mititelu Tartau, L; Ochiuz, L; Popa, EG; Stoleriu, I, 2014)
"This prospective, observational, multicenter study enrolled patients who consulted general practitioners across France for intense pain that lasted ≥7 days and for which the physician prescribed paracetamol-codeine or paracetamol-tramadol."3.79Semiological evaluation of pain according to its origin: a prospective, observational, and national study of current French medical practice. ( Bertin, P; Taieb, C, 2013)
" Tramadol/acetaminophen medication was effective in reducing pain in seven of nine cases(77."3.79[Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. ( Hirano, M; Kajita, Y; Nakahara, N; Noda, H; Takebayashi, S; Tanei, T; Wakabayashi, T, 2013)
" Paracetamol (acetaminophen) is generally recommended as a first-choice analgesic in osteoarthritis pain."3.79Managing osteoarthritis pain in the older population. ( Cunningham, E; Passmore, P, 2013)
"In pediatric palliative care, acetaminophen is also used as an adjuvant to opioid therapy for pain as well as an anti-pyretic."3.79Use of intravenous acetaminophen (paracetamol) in a pediatric patient at the end of life: case report. ( Keefer, P; Marks, AD; Saul, D, 2013)
"The responses pertaining to opioid agreements, urine drug testing, acetaminophen, and treatment for neuropathic pain are reassuring in that they prevent misuse and abuse of opioids, prevent acetaminophen-induced hepatotoxicity, and reflect evidence-based treatments."3.79Prescription patterns of pain medicine physicians. ( Avram, MJ; Benzon, HA; Benzon, HT; Cox, P; Dean, K; Katz, JA; Kendall, MC; Malik, K, 2013)
" Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests."3.78Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012)
"Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval."3.78Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012)
"This is a pharmacokinetic study of 30 postpartum women receiving hydrocodone bitartrate for postpartum pain in the inpatient setting."3.77Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. ( Anderson, PO; Lane, JR; Nguyen, N; Rafie, S; Rossi, SS; Sauberan, JB; Stellwagen, LM, 2011)
" This study was undertaken to determine the nature of the interaction between codeine and celecoxib or etoricoxib in peritoneal irritation-induced visceral pain in mice."3.77Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice. ( Janovsky, M; Krsiak, M, 2011)
"We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period."3.77Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011)
"The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain."3.76Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010)
"5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients."3.76Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients. ( Chang, CS; Chung, CY; Ho, ML; Hsu, NC; Lin, HY; Wang, CC, 2010)
"Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever in western countries."3.76Acetaminophen induces apoptosis in rat cortical neurons. ( Blanco, A; Ceña, V; Muñoz-Fernández, M; Posadas, I; Santos, P, 2010)
"001) dose-dependent analgesic effect in the tail flick, hot plate, and tail clip (central) as well as in acetic acid-induced writhing (peripheral) nociceptive tests in mice, suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response."3.76Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens. ( Kumar, CT; Mpharm, TB, 2010)
"Many traditional Indian medicinal plants which contain large quantity of a secoiridoid, swertiamarin are being used to relieve pain."3.75Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. ( Badami, S; Jaishree, V; Rupesh Kumar, M; Tamizhmani, T, 2009)
"Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet."3.75The analgesic effect of decursinol. ( Choi, SM; Huh, GH; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Sim, YB; Suh, HW, 2009)
"Studies from the UK and USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking."3.74The relation between paracetamol use and asthma: a GA2LEN European case-control study. ( Bergmann, KC; Bonini, S; Bruno, A; Burney, P; De Rudder, I; Fokkens, W; Gjomarkaj, M; Gnatiuc, L; Godnic-Cvar, J; Heinzerling, L; Janson, C; Joos, G; Kowalski, ML; Loureiro, C; Makowska, J; Pace, E; Potts, J; Sanjuas, C; Shaheen, S; Skadhauge, L; Thomsen, G; Todo-Bom, A; van Durme, Y; van Zele, T; Villanueva, CM; Weersink, EJ; Wöhrl, S; Zock, JP; Zuberbier, T, 2008)
"The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)."3.74Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007)
"Morphine and other opioids are the mainstay of cancer pain management, yet considerable fears surrounding them present barriers to pain control."3.74Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. ( Gooberman-Hill, R; Hanks, GW; Reid, CM, 2008)
"Acetaminophen is an effective mild analgesic and antipyretic agent."3.74Acetaminophen. ( Ameer, B; Greenblatt, DJ, 1977)
"Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain."3.73Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain. ( Aoe, T; Saito, O; Yamamoto, T, 2005)
" Ambulance officers' concern about the pain of injection is the major identified factor for the relative underuse of morphine observed in younger children."3.73Paediatric prehospital analgesia in Auckland. ( Watkins, N, 2006)
"The fixed combination of aspirin, paracetamol (acetaminophen) and caffeine has been used successfully to treat different kinds of pain including migraine attacks."3.73Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. ( Aicher, B; Akundi, RS; Candelario-Jalil, E; Fiebich, BL; Finkenzeller, G; Heinzmann, M; Hüll, M; Knörle, R; Mantovani, M; Schnierle, P, 2006)
"The analgesic and anti-hyperalgesic effects of cannabinoid- and vanilloid-like compounds, plus the fatty acid amide hydrolase (FAAH) inhibitor Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), and acetaminophen, were evaluated in the phenyl-p-quinone (PPQ) pain model, using different routes of administration in combination with opioid and cannabinoid receptor antagonists."3.73Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice. ( Cichewicz, DL; Haller, VL; Welch, SP, 2006)
" The aim of the study was to assess the effect of non-competitive NMDA antagonists and paracetamol (propacetamol) on pain threshold and analgesic potency of this drugs and their combinations in formalin model for pain in rats."3.73[Dextromethorphan enhances analgesic activity of propacetamol--experimental study]. ( Dobrogowski, J; Przewłocka, B; Wordliczek, J, 2005)
" Preterm (< 37 weeks) and term (37-41 weeks) infants received a single dose of propacetamol in the first 24 hours of life when they had minor, painful procedures or as additional treatment in infants receiving opioids."3.72Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age. ( Allegaert, K; Debeer, A; Devlieger, H; Pluim, MA; Tibboel, D; Van der Marel, CD; Van Lingen, RA; Vanhole, C, 2004)
"(1) First-line treatment for both acute and chronic pain is paracetamol or, if necessary, ibuprofen, a nonsteroidal antiinflammatory drug."3.72Paracetamol + tramadol: new preparation. No advance. ( , 2003)
"Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats."3.72Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats. ( Abelson, KS; Höglund, AU; Kommalage, M, 2004)
"To determine whether multiple dosing of acetaminophen would result in drug accumulation in polymedicated elderly patients with rheumatic pain."3.71Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain. ( Bannwarth, B; Lagrange, F; Le Bars, M; Matoga, M; Maury, S; Palisson, M; Pehourcq, F, 2001)
"To compare the hepatic and renal safety profiles of two daily dosage regimens of paracetamol (acetaminophen) (3 g versus 4 g) in patients with painful chronic rheumatoid diseases."3.71[Liver and renal tolerance to paracetamol: 3 g or 4 g per day?]. ( Ganry, H; Pruvot, F; Schmidely, N; Vesque, D, 2001)
" Postoperative pain was treated with morphine (median duration 4 days) or IV paracetamol (5 days)."3.71[Minimally invasive surgery for diverticula of the thoracic esophagus. Results in 11 patients]. ( Boudet, MJ; Carbonnel, F; Christidis, C; Denet, C; Gayet, B; Godeberge, P; Levard, H; Mal, F; Perniceni, T, 2001)
" In acute postoperative pain and chronic pain there is no proof that tramadol has a better risk-benefit ratio than the paracetamol + codeine combination or other step 2 analgesics in the World Health Organisation classification."3.70Tramadol: new preparation. Capsules: central analgesic; step 2 on the WHO scale. ( , 1998)
"Efficacy, tolerability and safety of Dipyrone (Novalgin) in the management of pain and fever in children."3.70Novalgin in pain and fever. ( Izhar, T, 1999)
"Hydrocodone is frequently prescribed in combination with acetaminophen for the relief of pain and has a side effects profile similar to other medications in its class."3.70Profound hearing loss associated with hydrocodone/acetaminophen abuse. ( Friedman, RA; Gherini, S; House, JW; Luxford, WM; Mills, D, 2000)
"(1) This codeine-based syrup is indicated for the treatment of pain in children."3.70Codeine for child pain: new preparation. Helpful in some cases. ( , 1999)
" Attention should be paid to the appearance of side-effects of morphine, the circulation of pain graduation tables and the evaluation of anxiety in this category of patient."3.69[Treatment of pain and anxiety in terminal oncologic patients in the Castilla-La Mancha community]. ( Calles Gato, MD; Hernández Moreno, J; López de Castro, F; Muñoz González, F; Sánchez del Viso, Y; Sánchez Muñoz, C, 1995)
"This retrospective review evaluated the pain management of 395 acutely burned pediatric patients who were treated by a pain management protocol emphasizing acetaminophen as the initial medication to control background pain."3.69Acetaminophen in the management of background pain in children post-burn. ( Blakeney, PE; Cortiella, J; Herndon, DN; Marvin, JA; Meyer, WJ; Nichols, RJ; Villarreal, C, 1997)
" A case of NAS due to codeine prescribed for pain relief during pregnancy is reported."3.69Neonatal abstinence syndrome due to codeine. ( Chang, J; Khan, K, 1997)
"The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat."3.68Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993)
"The traditional "aspirin first" approach to the treatment of osteoarthritis and rheumatoid arthritis is undergoing serious reappraisal."3.67Pain and inflammation. ( Calin, A, 1984)
"The analgesic effects of dextropropoxyphene and paracetamol and that of a combination of the two drugs were assessed in 24 patients who suffered from either rheumatoid arthritis or osteoarthritis."3.67Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis. ( Cunningham, TJ; Mathews, JD; Mitchell, H; Muirden, KD, 1984)
"A comparison was made between the relative effects of aspirin, mefenamic acid, dihydrocodeine , dextropropoxyphene and paracetamol on visceral pain (chemically-inducing writhing), respiratory rate and prostaglandin (PG) biosynthesis (cyclo-oxygenase activity)."3.67Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis. ( Gonzalez, JP; Pugh, J; Sewell, RD, 1984)
"Intrathecally administered substance P (SP) or capsaicin in mice elicited a pain-related behavioral response consisting of vigorous biting, licking and scratching of the caudal part of the body."3.67Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin. ( Fasmer, OB; Hole, K; Hunskaar, S, 1985)
"We studied the time course and intensity of pain of multiple bone marrow aspirations in 30 healthy adult marrow donors receiving acetaminophen with codeine for analgesia immediately after marrow harvesting for allogeneic bone marrow transplantation."3.67Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation. ( Chapman, CR; Hill, HF; Jackson, TL; Sullivan, KM, 1989)
"We studied the effects of two non-steroidal anti-inflammatory analgesics (NSAIAs), acetylsalicylic acid (ASA) and acetaminophen, on sleep patterns in rats with adjuvant-induced arthritis."3.67Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989)
"The effectiveness of nonprescription analgesics--acetaminophen and aspirin--in providing subjective relief of preoperative dental pain was evaluated in a varied population of adults."3.66Evaluation of acetaminophen and aspirin in the relief of preoperative dental pain. ( Kilkuts, A; Korberly, BH; Orkand, RK; Schreiber, GF; Segal, H, 1980)
"Worldwide, cancer pain management follows the World Health Organization (WHO) three-step analgesic ladder."3.11An international, open-label, randomised trial comparing a two-step approach versus the standard three-step approach of the WHO analgesic ladder in patients with cancer. ( Allende, S; Caraceni, A; Dierberger, K; Fallon, M; Gordon, D; Grant, L; Hall, PS; Kaasa, S; Laird, BJA; Lee, R; Leng, M; McWillams, K; Murray, GD; Norris, L; Reid, C; Sabar, R; Sande, TA; Verastegui, E, 2022)
"Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular."3.01Pharmacokinetic and pharmacodynamic herb-drug interactions of common over-the-counter pain medications. ( Sun, CK; Tsai, TH, 2023)
" Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects."3.01Common Selfcare Indications of Pain Medications in Children. ( Bell, J; Kachroo, P; Mossali, VM; Siddiqui, K; Zempsky, W, 2023)
"Pain is one of the most frequently reported experiences amongst children with Juvenile Idiopathic Arthritis (JIA); however, the management of JIA pain remains challenging."3.01A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis. ( Brandelli, YN; Chambers, CT; Huber, AM; Mackinnon, SP; Parker, JA; Piccolo, O; Stinson, JN; Wildeboer, EM; Wilson, JP, 2023)
"Cumulative pain is associated with morbidities, including adverse neurodevelopmental outcomes."3.01Breastfeeding or breast milk for procedural pain in neonates. ( Shah, PS; Shah, VS; Torgalkar, R, 2023)
" Current analgesics have adverse effects."3.01Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants. ( Banks, P; Boehm, KA; Bundrant, L; Gopinathan, S; Hunt, TL; Kassler-Taub, K; Tyle, P; Warner, C; Wason, S; Wilson, A, 2021)
" This trial aims to compare the pharmacokinetic (PK) parameters of paracetomol between the IV and SC routes in PC patients."2.94Intravenous versus subcutaneous route pharmacokinetics of paracetamol (acetaminophen) in palliative care patients: study protocol for a randomized trial (ParaSCIVPallia). ( Alix, A; Creveuil, C; Gourio, C; Guillaumé, C; Lelong-Boulouard, V; Lepoupet, M; Peyro-Saint-Paul, L; Vernant, M, 2020)
" However, further study should be conducted to find the optimal dosage of paracetamol for relieving the pain in amniocentesis along with a large RCT with a long-term follow-up to evaluate the side effects of paracetamol."2.87Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial. ( Pattanavijarn, L; Sudjai, D; Tuaktaew, T, 2018)
"Pain has a negative impact on life satisfaction (LS)."2.87Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients. ( Kokki, H; Kokki, M; Kuronen, M; Nyyssönen, T; Savolainen, S, 2018)
"Un(der)diagnosed and un(der)treated pain is a serious and frequent problem in persons with dementia."2.87Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial. ( Achterberg, WP; Caljouw, MAA; Gussekloo, J; Husebo, BS; van Dam, PH, 2018)
"Pain was assessed with the Premature Infant Pain Profile (PIPP) and the COMFORTneo score."2.84Randomized Controlled Trial Comparing Different Single Doses of Intravenous Paracetamol for Placement of Peripherally Inserted Central Catheters in Preterm Infants. ( Reiss, IKH; Roofthooft, DWE; Simons, SHP; Tibboel, D; van den Anker, JN; van Dijk, M; van Lingen, RA, 2017)
"The pain was scored through a 100-mm visual analog scale (VAS) immediately and 2 h after the procedure."2.82Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial. ( Abbasi, M; Agah, E; Ahmadi, M; Faghihi-Kashani, S; Kalantar, SS; Majedi, H; Tafakhori, A, 2016)
"Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery."2.82Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels. ( Eberhardt, E; Eberhardt, M; Leffler, A; Schillers, F, 2016)
" The objective of this study was to evaluate the effect of a dual-modality (written and spoken) literacy-appropriate educational strategy on patients' knowledge of and safe use of opioid analgesics."2.80Improving patient knowledge and safe use of opioids: a randomized controlled trial. ( Adams, JG; Ahlstrom, E; Cameron, KA; Chevrier, A; Courtney, DM; Engel, KG; McCarthy, DM; McConnell, R; Sears, J; Wolf, MS, 2015)
"Pain was measured using a 10-point visual analog pain scale during probe insertion, during the biopsy procedure, and 1 hour postbiopsy."2.80Intravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled study. ( Akand, M; Haliloglu, AH; Kilic, O; Kulaksizoglu, H; Piskin, MM; Tanidik, S; Yurdakul, T, 2015)
"Sixty patients with nonresectable pancreatic cancer reporting visual analog scale (VAS) ≥ 70 (visceral pain, continuous or intermittent) were randomized into 2 equal groups."2.78Comparative study between 2 protocols for management of severe pain in patients with unresectable pancreatic cancer: one-year follow-up. ( Amr, YM; Makharita, MY, 2013)
"Recent studies have linked patient misunderstanding of label instructions for as needed (PRN) medications to dosing errors."2.78Take-Wait-Stop: a patient-centered strategy for writing PRN medication instructions. ( Bailey, SC; Davis, TC; Jacobson, KL; King, JP; McCarthy, DM; Mullen, RJ; Parker, RM; Serper, M; Wolf, MS, 2013)
"Osteoporotic vertebral compression fractures (VCFs) are a major cause of increased morbidity in older patients."2.76Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. ( Alibai, E; Farrokhi, MR; Maghami, Z, 2011)
"Overall, pharmacokinetic data were roughly comparable with earlier publications, but differences were noted in the subgroup ICU patients."2.75Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance. ( Brüggemann, RJ; de Maat, MM; Ponssen, HH; Tijssen, TA, 2010)
"The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks."2.74Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. ( Forest, K; Girodet, PO; Jacquet, A; Mallet, L; Moore, N; Pariente, A, 2009)
"Acetaminophen (APAP) is a popular analgesic."2.73Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain. ( Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007)
" Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects."2.73The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. ( Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT, 2007)
" The acute pain models were not sufficiently sensitive to detect an analgesic effect of paracetamol or the combination with dextromethorphan."2.73Effects of paracetamol combined with dextromethorphan in human experimental muscle and skin pain. ( Ali, Z; Arendt-Nielsen, L; Drewes, AM; Olesen, AE; Staahl, C, 2007)
"In palliative cancer care, when approaching death, swallowing difficulties and the burden of tablet intake frequently makes us reconsider each individual drug prescribed."2.73Analgesic effect of paracetamol on cancer related pain in concurrent strong opioid therapy. A prospective clinical study. ( Axelsson, B; Stellborn, P; Ström, G, 2008)
" Despite its effectiveness, CDDP might cause severe toxic adverse effects on multiple body organs during cancer chemotherapy, including the kidneys, heart, liver, gastrointestinal tract, and auditory system, as well as peripheral nerves causing severely painful neuropathy."2.72Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity. ( El-Sheikh, A; Khired, Z, 2021)
"We extracted pain and adverse events outcomes from 36 systematic reviews that assessed the efficacy of paracetamol in 44 painful conditions."2.72The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. ( Abdel Shaheed, C; Ahedi, H; Day, RO; Dmitritchenko, A; Ferreira, GE; Kamper, S; Langendyk, V; Latimer, J; Lin, C; Maher, CG; McLachlan, AJ; McLachlan, H; Saragiotto, B; Stanaway, F, 2021)
"Pain was scored using a 1-6 faces scale."2.72Paediatric cancer pain management using the WHO analgesic ladder--results of a prospective analysis from 2265 treatment days during a quality improvement study. ( Andler, W; Hasan, C; Jorch, N; Michel, E; Smale, H; Zernikow, B, 2006)
"Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention."2.72Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. ( Brandt, KD; Buckwalter, KA; Mazzuca, SA, 2006)
"In addition to providing acute postoperative pain relief, preoperative PVB seems to reduce the prevalence of chronic pain 1 yr after breast cancer surgery."2.72Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. ( Bachmann, MS; Kairaluoma, PM; Pere, PJ; Rosenberg, PH, 2006)
"Naproxen and ibuprofen were more effective than acetaminophen in minimizing physical side effects of IFN beta-1a."2.71A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. ( Filipi, M; Healey, K; Leuschen, MP, 2004)
" Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited."2.71Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005)
"Pain was related to an infection in 98% of the cases."2.70[Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol]. ( Bernard-Fernier, MF; Cabane, J, 2001)
"Changes in menstrual pain intensity and duration, amount of bleeding measured according to the number of daily pads used and concomitant symptoms were assessed on the fifth day of each cycle."2.70Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial. ( de los Santos, AR; Di Girolamo, G; Martí, ML; Pérez Macri, S; Zmijanovich, R, 2001)
"CR codeine treatment resulted in significantly lower overall VAS pain intensity scores (35 +/- 18 vs."2.68Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial. ( Arkinstall, W; Babul, N; Darke, AC; Goughnour, B; Harsanyi, Z; Sandler, A, 1995)
" Tolerance in terms of withdrawals or side-effect profile did not appear to the dosage of each preparation administered."2.67The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips. ( Costello, F; Eves, MJ; James, IG; Lloyd, RS; Miller, AJ, 1992)
"Peak analgesia was reached after 2 h."2.67Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol. Double blind, placebo-controlled evaluation using painful laser stimulation. ( Arendt-Nielsen, L; Bjerring, P; Nielsen, JC; Petterson, KJ, 1992)
"Nimesulide was studied in comparison with paracetamol, according to a double-blind technique."2.67Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories. ( D'Apuzzo, V; Monti, T, 1992)
"It was confirmed that headache as a pain model does not show the usual return of pain with as the effects of a single analgesic dose wear off."2.67Evaluation of analgesic agents in recurring headache compared with other clinical pain models. ( Aimola, N; Gawel, MJ; Stiglick, A; Szalai, JF; Weiner, M, 1990)
"Acute soft tissue injuries are common and costly."2.66Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. ( Dalziel, SR; Jones, P; Lamdin, R, 2020)
"The rate of pregnant women with an opioid use disorder has risen drastically in the past 20 years, paralleling that in the general population."2.66Opioid Use and Misuse in Pregnancy. ( Landau, R; Shatil, B, 2020)
" The two drugs were found to have the same efficiency on the subjective parameters but high bioavailability glaphenine seems to have an effectiveness in the range of articulatory movements, which is not found with paracetamol."2.66Comparative study of high bio-availability glaphenine and paracetamol in cervical and lumbar arthrosis. ( Albert, A; Crielaard, JM; Franchimont, P; Urbin Choffray, D, 1987)
"Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine."2.66Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986)
"Pain was assessed prior to treatment, at 48 hours, and at one month using a visual analog scale."2.66Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain. ( Ordog, GJ, 1987)
" Patients were allocated at random to receive 2 tablets 3-times daily of either treatment for 6 weeks and were then crossed over to the alternative treatment at the same dosage for a further 6 weeks."2.65Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis. ( Boston, PF; Matts, SG, 1983)
" Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months."2.64Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974)
"Pain was more commonly reported by informal caregivers than the person with dementia themselves."2.61Pain assessment and pain treatment for community-dwelling people with dementia: A systematic review and narrative synthesis. ( Bartlam, B; Bedson, J; Bullock, L; Campbell, P; Chew-Graham, CA; Jordan, JL, 2019)
"Pain is an unpleasant side-effect that can be experienced during orthodontic procedures including debonding of fixed appliances."2.61Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review. ( Alharbi, F; Almuzian, M; Alomari, S; Mohammed, H; Rizk, MZ; Ulhaq, A, 2019)
"Pain during pregnancy is common, and its management is complex."2.61Medication Use and Pain Management in Pregnancy: A Critical Review. ( Black, E; Chutatape, A; Demirkol, A; Kennedy, D; Khor, KE; Sharma, S; Vancaillie, T, 2019)
" Given that these drugs also can modulate tissue protein turnover, it is important to scrutinize the implications of acute and chronic use of these drugs in relation to exercise performance and the development of long-term training adaptations."2.58Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations. ( Howatson, G; Lundberg, TR, 2018)
" This article presents different analgesic drugs, their mode of action, indications, dosage and adverse drug reactions."2.58[Pharmacological Basis of Pain Treatment]. ( Schüning, J; Schwarzer, A, 2018)
" The level of certainty for dosing recommendations obtainable from reviewing the evidence is low due to a small number of studies meeting search criteria, small samples sizes, inadequate information regarding cirrhosis etiology and compensated versus uncompensated liver disease, and lack of information on patient centered health outcomes."2.58A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease. ( Juba, KM; Schweighardt, AE, 2018)
" A variety of dosing regimens is therefore used off-label."2.55Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree. ( Allegaert, K; Calvier, EAM; Knibbe, CAJ; Mian, P; Tibboel, D, 2017)
"Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes."2.55Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017)
" Only pCGS is given as a highly bioavailable once daily dose (1500 mg) with a proven pharmacological effect."2.53A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes. ( Bruyère, O; Cooper, C; Kovalenko, V; Kucharz, EJ; Reginster, JY; Szántó, S, 2016)
"Fear of dental pain is a major barrier to treatment for children who need dental care."2.53Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. ( Anand, P; Ashley, PF; MacDonald, LC; Moles, DR; Parekh, S, 2016)
"Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States."2.52Intravenous acetaminophen use in pediatrics. ( Shastri, N, 2015)
" The evidence was usually either low quality or very low quality, reflecting study limitations, indirectness such from as suboptimal dosing of single comparators, imprecision, or one or more of these."2.52Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. ( Dalziel, SR; Frampton, C; Jones, P; Lamdin, R; Miles-Chan, JL, 2015)
" Dosage reduction and/or increased dose interval are often required."2.52[Analgesia in patients with hepatic impairment]. ( Innaurato, G; Piguet, V; Simonet, ML, 2015)
" Analgesic requirements are influenced by age-related changes in both pharmacokinetic and pharmacodynamic response, and increasing data are available to guide safe and effective dosing with opioids and paracetamol."2.50Neonatal pain. ( Walker, SM, 2014)
"His pain was scored as a five on a six-point visual analog scale, and it persisted despite routine supportive therapy."2.50[A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl]. ( Anzai, S; Hashimoto, Y; Nagasawa, K; Suzuki, T, 2014)
"Appropriate treatment of pain requires an understanding of the characteristics of pain, including the severity and the nature of the pain-for example, acute versus chronic pain or nociceptive versus neuropathic pain."2.49An overview of pain management: the clinical efficacy and value of treatment. ( Nalamachu, S, 2013)
"Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev."2.48Acetaminophen injection: a review of clinical information including forms not available in the United States. ( Beckwith, MC; Fox, ER; Jones, VM, 2012)
"Fear of dental pain is a major barrier to children needing dental care."2.48Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. ( Anand, P; Ashley, PF; Behbehani, A; Moles, DR; Parekh, S, 2012)
"The pain experienced by cancer patients can be managed in 70-90% of cases by the World Health Organisation protocol for cancer pain."2.47[Solutions for the clinical problems of analgesics for cancer pain treatment in Japan]. ( Kokubun, H; Matoba, M; Yago, K; Yamada, Y, 2011)
"Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev."2.47Acetaminophen injection: a review of clinical information. ( Jones, VM, 2011)
" In general, acetaminophen at reduced dosing is a safe option."2.46Pain management in the cirrhotic patient: the clinical challenge. ( Chandok, N; Watt, KD, 2010)
"Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects."2.45Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009)
" NSAIDs are typically more effective than acetaminophen; however, because of adverse effects associated with long-term use of NSAIDS, acetaminophen is considered first-line therapy."2.45Osteoarthritis: a review of treatment options. ( Dunican, KC; Lynch, AM; Seed, SM, 2009)
"Tramadol seems to be a potential useful analgesic for term neonates and infants, but has limited indications in (extreme) preterm neonates."2.44Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. ( Allegaert, K; de Hoon, J; Naulaers, G; Van De Velde, M, 2008)
" Referring to the current debate, potential mechanisms underlying cardiovascular side effects associated with long-term use of COX inhibitors are discussed."2.44Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolinones. ( Brune, K; Hinz, B, 2007)
"She is open to other therapeutic approaches and wants to know if acupuncture can help the pain, improve function, and stop her condition from progressing."2.44A 60-year-old woman considering acupuncture for knee pain. ( Berman, B, 2007)
"A time delay exists before drug reaches the effect compartment, and the equilibration half-time between the central and effect compartment is described by a single first-order parameter (Teq or T(1/2)keo), reported to be approximately 1 h for paracetamol."2.44Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration. ( Anderson, BJ; Gibb, IA, 2008)
"Acetaminophen is a safe medication that should be considered first-line therapy."2.44Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? ( Choquette, D; Craig, BN; Davis, P; De Angelis, C; Fulthorpe, G; Habal, F; Hunt, RH; Stewart, JI; Turpie, AG, 2007)
"Pain is an unpleasant sensation that originates from ongoing or impending tissue damage."2.44Recent advances in the pharmacological management of pain. ( Beaulieu, P; Guindon, J; Walczak, JS, 2007)
"Clinicians treating pain should be familiar with the actions, adverse effects, and individual agents in the group of nonopioid analgesics."2.44Nonopioid analgesics. ( Enany, N; Munir, MA; Zhang, JM, 2007)
"NSAIDs are widely applied to treat cancer pain and are frequently combined with opioids in combination preparations for this purpose."2.43NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. ( Carr, DB; Goudas, L; Lau, J; McNicol, E; Strassels, SA, 2005)
"Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events."2.43Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005)
"Pain is one of the most common reasons patients seek dental treatment."2.43Drugs for pain management in dentistry. ( Abbott, PV; Hargreaves, K, 2005)
" Dosing of both drug groups is tempered by concerns about toxicity."2.43Pain control: non-steroidal anti-inflammatory agents. ( Anderson, BJ; Jacqz-Aigrain, E, 2006)
" Major concerns in long-term use of anti-inflammatory drugs include renal toxicity, gastrointestinal ulceration and bleeding and cardiovascular events, which can be of particular concern for elderly patients."2.43Pharmacological aspects of successful long-term analgesia. ( Raffa, R, 2006)
" The review establishes that aspirin, paracetamol and ibuprofen are safe in OTC doses and that there is no evidence for any difference between the medicines as regards efficacy and safety for treatment of colds and flu (except in certain cases such as the use of aspirin in feverish children)."2.43Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. ( Eccles, R, 2006)
" Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease."2.43Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006)
"Chronic pain has a growing incidence with age."2.43[Management strategies for the treatment of non malignant chronic pain in the elderly]. ( Perrot, S, 2006)
"Persons with advanced CKD and ESRD are at increased risk for adverse effects of analgesic agents because of enhanced drug sensitivity, comorbid conditions, and concurrent medication use."2.42Analgesia in patients with ESRD: a review of available evidence. ( Bennett, WM; Chertow, GM; Kurella, M, 2003)
" Although the bioavailability of paracetamol is not impaired in patients with chronic, benign liver diseases, the agent is contraindicated in those with hepatic insufficiency."2.42[Pharmacologic basis for using paracetamol: pharmacokinetic and pharmacodynamic issues]. ( Bannwarth, B; Péhourcq, F, 2003)
" Better dosage forms are also required for rectal administration."2.42[New perspectives on paracetamol]. ( Prescott, LF, 2003)
"Pain is a common reason to attend hospital but it is often inadequately managed."2.42Pharmacological techniques for managing acute pain in emergency departments. ( Butcher, D, 2004)
"Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day."2.42Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004)
"Codeine is an opiate with uncertain and unpredictable effects."2.42[Problem forte--is paracetamol-codeine combination rational?]. ( Helland, A; Slørdal, L; Spigset, O, 2004)
"The standard pillar of postoperative treatment of severe pain is the use of opioids."2.41Non-opioid postoperative analgesia. ( Dahl, V; Raeder, JC, 2000)
"If untreated, the pain of circumcision causes both short and long term changes in infant behaviours."2.41Pain management for neonatal circumcision. ( Taddio, A, 2001)
" In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury."2.41Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000)
"Pain is a significant problem in many patients with genitourinary malignancy at all stages of disease."2.41Update on pain management for advanced genitourinary cancer. ( Harrison, P, 2001)
"Pain is the most prominent symptom and clinical finding in osteoarthritis (OA)."2.41Treatment of chronic pain in osteoarthritis: do opioids have a clinical role? ( Lipman, AG, 2001)
"Pyoderma gangrenosum is used as the basis for applying the new pain standards."2.41Pyoderma gangrenosum: a case study for pain management in dermatology nursing. ( Dunwoody, CJ; McCann, SA; Zumbo, M, 2000)
" During repeated dosage with the specific COX-2 inhibitors, the 24 hour urinary excretion of sodium is only inhibited for the first day of treatment while the excretion of sodium is still decreased over the first 3 hours after the individual doses."2.41Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). ( Day, RO; Graham, GG; Graham, RI, 2002)
"Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity."2.40Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997)
") After initiating morphine or making any change of dose or route of administration, the dosage should be evaluated after approximately 24 hours."2.40The management of chronic pain in patients with breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Society of Palliative Care Physicians. Canadian Association of Radiation Oncologist ( , 1998)
"Chronic pain affects 75 million US citizens."2.40Non-NSAID pharmacologic treatment options for the management of chronic pain. ( Schnitzer, TJ, 1998)
"Data on assessment and treatment of spinal cord compression are reviewed."2.40Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. ( Abrahm, JL, 1999)
"Acetaminophen is a suitable substitute for aspirin for its analgesic or antipyretic uses in patients in whom aspirin is contraindicated (e."2.39Acetylsalicylic acid and acetaminophen. ( Kacso, G; Terézhalmy, GT, 1994)
"Acetaminophen is a safe antipyretic therapy prescribed in children."2.39[Paracetamol and other antipyretic analgesics: optimal doses in pediatrics]. ( Stamm, D, 1994)
"Pain is a common and complex problem in the geriatric population."2.39Pain management for the geriatric patient. ( Forman, WB; Roche, RJ, 1994)
" In general, dosage escalation and compulsive drug-seeking behaviors were not seen."2.38Pharmacologic management of pain in children and adolescents. ( Berde, CB; Shannon, M, 1989)
"Acetaminophen is an effective antipyretic and analgesic with few side effects that is toxic only in massive overdose."2.36Use of antipyretic analgesics in the pediatric patient. ( Gladtke, E, 1983)
"Aspirin has some advantage over acetaminophen for analgesia."2.36Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity. ( Lovejoy, FH, 1978)
"Pain is common among cirrhosis patients, particularly those hospitalized with acute illness."1.91Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis. ( Auerbach, A; Hohmann, SF; Lai, JC; Rubin, JB; Shui, AM, 2023)
"Inflammatory pain is part of the body's defense mechanism and plays an important role in the healing process."1.91Modulation of inflammatory mediators involved in the antinociceptive and anti-inflammatory effects of a new thioamide derivative: thiocyanoacetamide. ( Ben Akacha, A; Ben Ali, R; Ben Othman, A; El May, MV, 2023)
" Pharmacokinetic parameters for the parent compound were estimated with a nonlinear mixed-effects model."1.91Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study. ( Avachat, C; Barry, JM; Birnbaum, AK; Brink Henriksen, T; Christensen, U; Dalhoff, K; Haslund-Krog, S; Holst, H; Poulsen, S; Remmel, RP; Sherwin, CMT; van den Anker, JN; Wilkins, D, 2023)
"The origin of pain is likely neuropathic."1.91Mpox Pain Management with Topical Agents: A Case Series. ( Bugayong, ML; DeVita, MA; Shabbir, M, 2023)
"The characteristics of cervicogenic headache were summarized, the numerical rating score (NRS) of patients before and after treatment of compound opioids and/or cervical nerve block was compared, and the occurrence of related adverse reactions and complications was counted."1.91[Clinical characteristics and therapeutic effectiveness of post craniotomy cervicogenic headache]. ( Huang, Y; Luo, F; Meng, L; Zhou, R, 2023)
" Antinociception was assessed by dose-response curves to paracetamol and meloxicam before and after the i."1.72Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2022)
" A two-compartment pharmacokinetic model with first-order elimination described disposition for both drugs."1.72Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers. ( Anderson, BJ; Atkinson, HC; Morse, JD; Stanescu, I, 2022)
"In dentistry, pain is a rather inevitable perception that often plagues both the care provider and receiver."1.72Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study. ( Kaarthikeyan, G; Murthykumar, K; Rajasekar, A, 2022)
"Ketorolac was not associated with increased risk of postoperative bleeding (0."1.72Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort. ( Bowman, A; Brant, A; Johnson, JP; Lewicki, P; Shoag, JE; Sze, C; Weinstein, IC, 2022)
"Pain is a major problem that burdens the health and economy of societies worldwide."1.72Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats. ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022)
"Legg-Calvé-Perthes disease (LCPD) and slipped capital femoral epiphysis (SCFE) can result in painful deformation of the hip joint with impaired range of motion and early development of secondary osteoarthritis."1.72Pediatric Hip Disease Increases the Risk for Opioid Use in Adulthood: Long-term Burden of Pain and Depression. ( Hailer, YD; Wadström, MG, 2022)
"Pain was assessed using the Mobilization-Observation-Behavior-Intensity-Dementia-2 (MOBID-2) Pain Scale."1.72Prevalence and persistent prescription of analgesic drugs in persons admitted with dementia to a nursing home - A longitudinal study. ( Bergh, S; Helvik, AS; Husebø, B; Kabukcuoğlu, K; Lichtwarck, B; Šaltytė Benth, J; Tevik, K, 2022)
"Pain is one of the most common and debilitating symptoms of hidradenitis suppurativa (HS)."1.72Pain management modalities for hidradenitis suppurativa: a patient survey. ( Borgstrom, M; Fernandez, JM; Hsiao, JL; Orenstein, LAV; Shi, VY; Thompson, AM, 2022)
"Pain is highly prevalent among older people, and treatment is complicated because of comorbidities and polypharmacy."1.62Pharmacological Pain Treatment in 2012 and 2017 Among Older People with Major Neurocognitive Disorder. ( Gustafsson, M; Lövheim, H; Sjölander, M, 2021)
" Overall, these systems could significantly enhance the bioavailability of paracetamol and prolong its therapeutic effect in numerous diseases such as cold, flu, COVID-19, and severe pain."1.62Overcoming the paracetamol dose challenge with wrinkled mesoporous carbon spheres. ( Ejsmont, A; Galarda, A; Goscianska, J; Olejnik, A; Wuttke, S, 2021)
"Women with preeclampsia had used significantly more often paracetamol during pregnancy compared to controls (cases 8."1.62Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence? ( Keski-Nisula, L; Sahlman, H; von Hellens, H, 2021)
"Pain is a common but often ignored symptom in COVID-19 patients."1.62COVID-19'da İhmal Edilen Semptom: Ağrı. ( Sir, E, 2021)
"Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs)."1.62Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis. ( Doherty, M; Lei, G; Persson, MSM; van Middelkoop, M; Wei, J; Xiong, Y; Zeng, C; Zhang, W, 2021)
"Childhood burns are common and distressing for children and their parents."1.56Pain Management for Pediatric Burns in the Outpatient Setting: A Changing Paradigm? ( Bielsky, A; Goldsmith, A; Meier, M; Moulton, S; Phillips, R; Recicar, J; Shahi, N; Shirek, G; Yaster, M; Zuk, J, 2020)
"Pain is a hallmark of this condition and can be extremely difficult to control."1.56Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020)
"Endometriosis is characterized by abdominopelvic hypersensitity."1.51Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis. ( Awaga, Y; Hama, A; Hayashi, I; Matsuda, A; Natsume, T; Ogawa, S; Takamatsu, H; Yano, M, 2019)
"Pain is a common and distressing symptom of pediatric cancer, as reported by both children and their parents."1.48Pain in Children With Cancer: Prevalence, Characteristics, and Parent Management. ( Barwick, M; Campbell, F; Chambers, CT; Fernandez, CV; Irwin, K; Jibb, LA; Nathan, PC; Parker, JA; Stinson, JN; Tutelman, PR; Witteman, HO, 2018)
"Placebo effects on pain have been found to vary in size for different routes of medication administration (e."1.48Expectations about the effectiveness of pain- and itch-relieving medication administered via different routes. ( Evers, AWM; Peerdeman, KJ; Peters, ML; Rippe, RCA; Tekampe, J; van Laarhoven, AIM; van Middendorp, H, 2018)
" The intake frequency and dosage of Paracetamol varied between the women and was overall low with a tendency towards higher frequencies and higher dosages in the third trimester."1.46Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort. ( Arck, PC; Becher, H; Bremer, L; Diemert, A; Gehbauer, C; Goletzke, J; Hecher, K; Pagenkemper, M; Tiegs, G; Tolosa, E; Wiessner, C, 2017)
"Routine oral dosing practices in a SSA hospital resulted in substantial underexposure to paracetamol."1.46Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study. ( Bos, JC; Mathôt, RAA; Mistício, MC; Nunguiane, G; Prins, JM; van Hest, RM, 2017)
"Acetaminophen was administered 2."1.46Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. ( Moody, MA; Saleh, E; Swamy, GK; Walter, EB, 2017)
"Morphine dosage was calculated as the cumulative dose administered during the neonatal intensive care unit period."1.43Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants. ( Aikio, O; Hallman, M; Härmä, A; Saarela, T, 2016)
"Meperidine was applied to animals with increasing doses and their tail flick latencies (TFL) were noted at 20, 40, 60, 90, 120, 180, and 240 min."1.43Combination of paracetamol or ketamine with meperidine enhances antinociception. ( Akkar, OB; Cetin, A; Cetin, M; Gulturk, S; Kula, A, 2016)
" For residents with scheduled medication, dosage and duration of use were analysed."1.43Pain medication in German nursing homes: a whole lot of metamizole. ( Hoffmann, F; Schmiemann, G, 2016)
"Acetaminophen was discontinued and IV acetylcysteine was given and continued at the second maintenance dose rate for a second 16-hour infusion, at which time transaminases, INR, ammonia and total bilirubin were all improving."1.43Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen. ( Anderson, VE; Dart, RC; Green, JL; Heard, KJ; Kovnat, D; Seifert, SA, 2016)
"Acetaminophen was administered at a dose of 600 mg (14."1.43Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs. ( KuKanich, B, 2016)
" IV and PO APAP doses administered with a predose pain score ≥4 within 1 h of dosing were compared."1.43Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. ( Brophy, GM; Nadpara, PA; Nichols, DC; Taylor, PD, 2016)
"Pain is a major problem in all cancer stages."1.42Adaptation of an evidence-based clinical practice guideline in cancer pain management by medical oncologists: a case vignette study. ( Besse, K; Engels, Y; te Boveldt, N; Vernooij-Dassen, M; Vissers, K, 2015)
" Ten percent of literate respondents were unable to understand the dosage requirements for children."1.42"But it's just paracetamol": Caregivers' ability to administer over-the-counter painkillers to children with the information provided. ( Bennin, F; Rother, HA, 2015)
"Although daytime sleepiness occurred in a large number of residents, especially those with dementia, this sleepiness was not necessarily associated with use of opioids."1.42Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities. ( Bell, JS; Emery, T; Hilmer, SN; Hughes, JM; Ilomäki, J; Jones, MJ; Moawad, S; Quirke, T; Robson, L; Tan, EC; Visvanathan, R; Vitry, AI, 2015)
"Acute dental pain is a recognised precipitant of unintentional paracetamol overdose and in a small but significant number of cases this results in hepatotoxicity."1.40Identifying adults at risk of paracetamol toxicity in the acute dental setting: development of a clinical algorithm. ( Byers, J; Marney, C; Nayyer, NV, 2014)
"Additionally, areas of flare and secondary hyperalgesia were mapped, and time course of hyperalgesia determined."1.40An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. ( Henrich, F; Jürgens, TP; Magerl, W; May, A; Sawatzki, A, 2014)
"Pain is the presenting symptom in 20 to 30% of patients with autosomal dominant polycystic kidney disease (ADPKD) and occurs in 50 to 60% of patients at some stage of the disease process, but its frequency increases with age and size of the cysts."1.40Pain in renal disease. ( Santoro, D; Satta, E, 2014)
"Pain is a common symptom associated with cancer and its treatment."1.39Adult cancer pain. ( Abernethy, AP; Anghelescu, DL; Benedetti, C; Buga, S; Cleeland, C; Deleon-Casasola, OA; Dwyer, M; Eilers, JG; Ferrell, B; Green, M; Janjan, NA; Kamdar, MM; Kumar, R; Levy, MH; Lynch, M; McDowell, RM; Moryl, N; Nesbit, SA; Paice, JA; Rabow, MW; Swarm, RA; Syrjala, KL; Urba, SG; Weinstein, SM, 2013)
"Acetaminophen (paracetamol) is a widely used analgesic, but its sites and mechanisms of action remain incompletely understood."1.39Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. ( Liu, J; Reid, AR; Sawynok, J, 2013)
" Paracetamol (acetaminophen in North America) has better bioavailability when given intravenously than orally and has been successfully used in the postoperative care of orthopedic patients."1.39Can intravenous paracetamol reduce opioid use in preoperative hip fracture patients? ( Mackenney, P; Page, J; Tsang, KS, 2013)
"FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety."1.39Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology. ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013)
"Acetaminophen itself was not toxic to developing mouse cortical neurons at therapeutic concentrations of 10-250 μg/ml."1.38Effects of the analgesic acetaminophen (Paracetamol) and its para-aminophenol metabolite on viability of mouse-cultured cortical neurons. ( DeSilva, M; Gu, TT; Qiang, M; Schultz, S; Whang, K, 2012)
"Pain is a prominent symptom in radiotherapy-induced oral mucositis (OM)."1.37Individualized pharmacological treatment of oral mucositis pain in patients with head and neck cancer receiving radiotherapy. ( Larsson, B; Ling, IS, 2011)
"The aim of the study was to analyze factors predicting pain relief and adverse events in patients receiving opioids for acute pain in a prehospital setting."1.37Predictors of pain relief and adverse events in patients receiving opioids in a prehospital setting. ( Barniol, C; Bounes, V; Ducassé, JL; Houze-Cerfon, CH; Minville, V, 2011)
"In a rat incision model of postoperative thermal hyperalgesia, coadministration of nefopam at a non-analgesic dose (3 mg/kg) with paracetamol at a low analgesic dose (300 mg/kg) showed the appearance of a strong antihyperalgesic effect, maintained for at least 3 h."1.37Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. ( Coppé, MC; Girard, P; Niedergang, B; Pansart, Y; Verleye, M, 2011)
" First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances."1.37Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011)
"A population pharmacokinetic analysis of 943 paracetamol observations from 158 neonates (27-45 weeks' postmenstrual age (PMA)) was undertaken using non-linear mixed effects models."1.37The pharmacokinetics of intravenous paracetamol in neonates: size matters most. ( Allegaert, K; Anderson, BJ; Palmer, GM, 2011)
"Important levels of fatigue are common in knee and hip OA patients."1.37Fatigue in knee and hip osteoarthritis: the role of pain and physical function. ( Arts-Sanders, MA; Defoort, KC; den Broeder, AA; Fransen, J; Snijders, GF; Stukstette, MJ; van den Ende, CH; van den Hoogen, FH; van Riel, PL, 2011)
"Pain is among the most frequent and distressing symptoms in terminally-ill cancer and, to date, many patients still experience uncontrolled pain."1.37[Pain assessment in terminally-ill cancer patients on admission in hospice and its modification after the first three days of care. A monocentric experience]. ( Bordin, F; D'Addario, ME; Di Miele, D; Fava, A; Ferraccioli, A; Lanzetta, G; Ranucci, A; Rozzi, A; Salerno, M; Scirocchi, R; Terzoli, L, 2011)
" Adoption of these two recommendations may lead to the increased use of NSAIDs with the potential of increasing incidence of NSAIDs-related adverse reactions."1.36FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable? ( Day, RO; Graham, GG; Graudins, A; Mohamudally, A, 2010)
"Pain was much more prevalent among our CKD compared with non-CKD patients."1.36Pain prevalence in patients with chronic kidney disease. ( Dewar, K; Hashmi, S; Pham, PA; Pham, PC; Pham, PM; Pham, PT; Toscano, E, 2010)
"Oral acetaminophen was the most commonly prescribed medication (131 patients, 62."1.36Triage pain scales cannot predict analgesia provision to pediatric patients with long-bone fracture. ( Chang, YC; Lin, YJ; Weng, YM, 2010)
"Dysmenorrhea was more prevalent among nutrition and psychology students than among medicine, pharmacy and dentistry students (p<0."1.36Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. ( Ortiz, MI, 2010)
"Acetaminophen is an analgesic and antipyretic drug believed to exert its effect through interruption of nociceptive processing."1.35Acetaminophen prevents hyperalgesia in central pain cascade. ( Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL, 2008)
"Thermal hyperalgesia was also decreased by intraplantar treatment with morphine (10 microg) or diclofenac (100 microg)."1.35Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat. ( Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J, 2009)
"Dextropropoxyphene is a weak opioid analgesic, widely used as a step 2 analgesic (according to WHO classification) in combination with peripheral analgesics, mainly paracetamol."1.35Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption. ( Damase-Michel, C; Gaubert, S; Montastruc, JL; Pathak, A; Vié, M, 2009)
" Over 80% of total daily dosing from age 36 weeks PCA to 1 year fell within dosing suggested by pharmacokinetic studies."1.35Survey of i.v. paracetamol (acetaminophen) use in neonates and infants under 1 year of age by UK anesthetists. ( Morton, NS; Wilson-Smith, EM, 2009)
"Evaluate the efficiency of the treatment of pain by analgesic according to World Health Organization (WHO)."1.35[Treatment of sickle cell pain]. ( Coulibaly, Y; Dembele, A; Diakite, AA; Dicko-Traore, F; Keita, MM; Sidibe, T; Sylla, M; Togo, B; Traore, B, 2009)
"Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline."1.35Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008)
"Trigeminal neuralgia is a condition which often can be diagnosed on the basis of the clinical history and the specific symptoms."1.35[Atypical pain in the mandible caused by trigeminal neuralgia]. ( Griëntschnig, CG; Scheltens, P; van der Waal, I, 2008)
" The survey showed a wide variation in morphine and paracetamol dosing and the absence of a paracetamol loading dose in a fourth of the units."1.35Pain management in Swedish neonatal units--a national survey. ( Eriksson, M; Gradin, M, 2008)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."1.34Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
"Thermal hyperalgesia was induced by mild heat injury (51 degrees C water for 20 s) which led to a 7-8 degrees C decrease of the noxious heat threshold."1.34Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. ( Bölcskei, K; Horváth, D; Petho, G; Szolcsányi, J, 2007)
"Although acute pain is frequently reported by patients admitted to the emergency room, it is often insufficiently evaluated by physicians and is thus undertreated."1.34Acute pain in adults admitted to the emergency room: development and implementation of abbreviated guidelines. ( Blanc, C; Buclin, T; Decosterd, I; Givel, JC; Hugli, O; Mouhsine, E; Tamchès, E; Yersin, B, 2007)
"Immunization pain is a global public health issue."1.34Routine immunization practices: use of topical anesthetics and oral analgesics. ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007)
"To describe the treatment of knee pain in older adults in primary care and to compare reported practice with published evidence."1.34Primary care treatment of knee pain--a survey in older adults. ( Croft, P; Jinks, C; Jordan, K; Porcheret, M, 2007)
" Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol."1.34Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007)
"Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated or chronic phase, and also for advanced gastrointestinal stromal tumors."1.34Imatinib-induced fatal acute liver failure. ( Cacchione, R; Gadano, AC; Mandó, OG; Marciano, S; Ridruejo, E; Villamil, AG, 2007)
"In elderly persons, pain is a common problem, and analgesic medicines are among the most frequently used drugs."1.33Balancing pain and analgesic treatment in the home-dwelling elderly. ( Hartikainen, SA; Louhivuori-Laako, KA; Mäntyselkä, PT; Sulkava, RO, 2005)
"Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase."1.33Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice. ( Choi, SS; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW, 2005)
"Ibuprofen based drugs were the most frequently used OTC in both surveys (57% Roper, 33% NCL)."1.33Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs. ( Cryer, B; Triadafilopoulos, G; Wilcox, CM, 2005)
"However, if pain is unmanageable in the outpatient department, we believe that options include hospital admission, using the contained method of application or, in the worst case scenario, cessation of treatment."1.33Determining pain levels in patients treated with maggot debridement therapy. ( Budding, T; Oskam, J; Steenvoorde, P, 2005)
" The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID."1.33Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. ( Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2006)
"Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid."1.32Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004)
"In aggregate, 2195 patients (31% with cancer diagnoses per the International Classification of Diseases, Ninth Revision, Clinical Modification) received oxycodone/acetaminophen for more than 9 months at a mean prescribed daily dose of 3."1.32Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. ( Fiore, LD; Gagnon, DR; Hermos, JA; Young, MM, 2004)
"Nonpharmacologic approaches such as cognitive-behavioral therapy, education, osteopathic manipulative treatment, and exercise should be applied in addition to pharmacologic therapy."1.31Pain management in the elderly. ( Cavalieri, TA, 2002)
"The NCCN Cancer Pain Practice Guidelines Panel believes that cancer pain can be well controlled in the vast majority of patients if the algorithms presented are systematically applied, carefully monitored, and tailored to the needs of the individual patient."1.31NCCN Practice Guidelines for Cancer Pain. ( Benedetti, C; Brock, C; Cleeland, C; Coyle, N; Dubé, JE; Ferrell, B; Hassenbusch, S; Janjan, NA; Lema, MJ; Levy, MH; Loscalzo, MJ; Lynch, M; Muir, C; O'Neill, A; Oakes, L; Payne, R; Syrjala, KL; Urba, S; Weinstein, SM, 2000)
"The diagnosis of idiopathic plantar hidradenitis was considered, and then confirmed in one case by plantar biopsy."1.31[Eccrine neutrophilic hidradenitis: idiopathic plantar form in children]. ( David, L; Erro-Vincent, T; Fouilhoux, A; Kanitakis, J; Souillet, AL, 2001)
"The pain was measured by using a visual analog scale (VAS)."1.31Pain experience during transvaginal aspiration of immature oocytes. ( Hildebrandt, NB; Høst, E; Mikkelsen, AL, 2001)
"According to the degree of importance to the combined analgesic effect, Ace > Caf > Bul; Ace showed a significant dose-response relationship, whereas in Caf and Bul, this relationship was not apparent."1.31Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital. ( Gui, CQ; Sun, RY; Wang, XW; Zheng, QS, 2001)
"Pretreatment with naloxone abolished this antinociceptive activity both in the hot-plate test and in the first phase of the formalin test without affecting the serum concentration of paracetamol."1.30Naloxone-reversible antinociception by paracetamol in the rat. ( Ottani, A; Pini, LA; Sandrini, M; Vitale, G, 1997)
" Tablets "Paravit" have mark, which allows exact dosing for children of different age."1.30[The physiological properties of the action of a new analgesic and antipyretic preparation]. ( Chernykh, VP; Shapovalova, VO, 1997)
"There are no adequate pharmacodynamic data relating concentrations of acetaminophen in serum to analgesia."1.30Perioperative pharmacodynamics of acetaminophen analgesia in children. ( Anderson, BJ; Holford, NH; Kanagasundaram, S; Mahadevan, M; Woollard, GA, 1999)
"Diclofenac was the NSAID of choice for 69."1.30Analgesia in soft-tissue injury: current practice in Auckland is not supported by the available evidence. ( Jones, PG, 1999)
"Twenty patients with end-stage head and neck cancer, unresponsive to either acetaminophen with codeine or oxycodone hydrochloride, were placed on a four-drug analgesic regimen consisting of methadone hydrochloride, Trilisate or acetaminophen, a tricyclic antidepressant, and, in most cases, hydroxyzine."1.29A four-drug pain regimen for head and neck cancers. ( Carrol, EN; Fine, E; Ruff, RL; Stepnick, D, 1994)
"Osteoarthritis is a chronic disease that has exacerbations and remissions."1.29Osteoarthritis treatment update. Minimizing pain while limiting patient risk. ( Schnitzer, TJ, 1993)
"The gene for sickle cell disease is carried by 8% of the African-American population in the United States."1.28Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992)
"Continuous Reaction Time (CRT) was measured in cancer patients receiving peripherally acting analgesics either alone (n = 16) or in combination with opioids (n = 16)."1.28Reaction time in cancer patients receiving peripherally acting analgesics alone or in combination with opioids. ( Banning, A; Kaiser, F; Sjøgren, P, 1992)
" Incidence of side effects and toxicity may be reduced by choice of drug and modification of dosing regimen."1.28Nonnarcotic analgesics and tricyclic antidepressants for the treatment of chronic nonmalignant pain. ( Richlin, DM, 1991)
"Acetaminophen is an effective analgesic and antipyretic agent with few adverse effects when used in recommended dosages."1.27Acetaminophen: a practical pharmacologic overview. ( Cornett, JW; Jackson, CH; MacDonald, NC, 1984)
" FS 205-397 will offer potent analgesic and antipyretic therapy in man based on an innovative biochemical principle which eliminates the undesirable toxic effects associated with most other non-narcotic analgesics."1.27FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice. ( Achini, R; Foote, RW; Römer, D, 1988)
"On the other hand, certain tumors require local blockade as in cases with pancreatic or perianal tumors."1.27[Therapy of pain caused by gastrointestinal tumors]. ( Zenz, M, 1987)
" Patients were maintained on their normal treatment and dosage schedules (600 mg every 3 to 8 h) for the study."1.27The effect of acetaminophen administration on its disposition and body stores of sulphate. ( Danilkewich, A; Hendrix-Treacy, S; Hindmarsh, KW; Wallace, SM; Wyant, GM, 1986)
"Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially."1.26Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. ( Lovejoy, FH; Mitchell, AA; Shapiro, S; Slone, D, 1982)
" A significant reduction in the LD50 was seen in the alcohol-pretreated mice, and correlations were noted between histological findings in the liver and the LD50 data."1.26Potentiation of acetaminophen hepatotoxicity by alcohol. ( Holtzman, JL; Kromhout, JP; McClain, CJ; Peterson, FJ, 1980)
"Phenacetin was active in the trypsin and kaolin assays with oral ED50's of 114 +/- 36."1.26Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents. ( Selph, JL; Truax, JF; Vinegar, R, 1976)
" In therapeutic dosage of 6 to 12 mg."1.23The sublingual administration of curare. ( MAYER, H; NEFF, WB, 1953)

Research

Studies (1,152)

TimeframeStudies, this research(%)All Research%
pre-1990185 (16.06)18.7374
1990's114 (9.90)18.2507
2000's334 (28.99)29.6817
2010's383 (33.25)24.3611
2020's136 (11.81)2.80

Authors

AuthorsStudies
Shinoda, S1
Aoyama, T1
Aoyama, Y1
Tomioka, S1
Matsumoto, Y1
Ohe, Y1
Friesen, RW1
Mancini, JA1
de Campos Buzzi, F1
Franzoi, CL1
Antonini, G1
Fracasso, M2
Cechinel Filho, V1
Yunes, RA3
Niero, R2
Tripathi, P1
Tripathi, AC1
Chawla, V1
Saraf, SK1
Å Nilsson, JL1
Mallet, C4
Shionoya, K1
Blomgren, A1
Sundin, AP1
Grundemar, L1
Boudieu, L1
Blomqvist, A1
Eschalier, A12
Nilsson, UJ1
Zygmunt, PM1
Murphy, V1
Koea, J1
Srinivasa, S1
Schuler, M1
Rubin, JB1
Lai, JC1
Shui, AM1
Hohmann, SF1
Auerbach, A1
Gustafsson, M1
Lövheim, H1
Sjölander, M1
Hickey, T1
Abelleira, A1
Acampora, G1
Becker, WC1
Falker, CG1
Nazario, M1
Weimer, MB1
Patterson, TG1
Beckenkamp, P1
Ferreira, M1
Turner, J1
Gnjidic, D1
Chen, Y1
Mesa Castrillion, CI1
Ferreira, P1
Rogers, TS1
Chandler, M1
Hall, A1
Miranda, HF6
Noriega, V3
Sierralta, F3
Sotomayor-Zárate, R1
Prieto, JC6
Martínez-Martínez, MDC1
Parra-Flores, LI1
Baeza-Flores, GDC1
Torres-López, JE1
El-Sheikh, A1
Khired, Z1
Owayda, AM1
Hajeer, MY1
Murad, RMT1
Al-Sabbagh, R1
Friedlander, EB1
Raidoo, S1
Soon, R1
Salcedo, J1
Davis, J1
Tschann, M1
Fontanilla, T1
Horiuchi, W1
Kaneshiro, B1
Kara, A1
Büyükcam, A1
Sütçü, M1
Sali, E1
Bozdemir, ŞE1
Kara, M1
İlarslan, EÇ1
Kaya, C1
Karakaşlılar, S1
Sönmez, G1
Kara, SS1
Bedir, T1
Albayrak, E2
Kara, TT1
Çelebi, S1
Öz, FN1
Karbuz, A1
Somer, A1
Alabaz, D1
Tezer, H1
Özdemir, H1
Çiftçi, E1
Morse, JD1
Stanescu, I1
Atkinson, HC1
Anderson, BJ6
Murthykumar, K1
Rajasekar, A1
Kaarthikeyan, G1
Constantin, KL1
Lupo-Flewelling, K1
Moline, RL1
McMurtry, CM1
Guo, J1
Wang, T1
Zheng, X1
Long, Y1
Wang, X2
Zhang, Q1
Liu, J2
Zhang, G1
Zha, J1
Hou, Z1
Zhang, Y3
Lee, N1
Mårtensson, LB1
Ezzati, A1
Fanning, KM1
Buse, DC1
Pavlovic, JM1
Armand, CE1
Reed, ML1
Martin, VT1
Lipton, RB1
Reynolds-Wright, JJ1
Woldetsadik, MA1
Morroni, C1
Cameron, S1
Bozorgmanesh, M1
Valibeik, S1
Shokrpour, M1
Maktabi, M1
Kamali, A1
Thirunavukarasu, AJ1
Hassan, R1
Savant, SV1
Hamilton, DL1
Smith, MD1
Rowan, E1
Spaight, R1
Siriwardena, AN1
Ruffin, TB1
Salinero, E1
Papa, L1
Cramm, K1
Florez, C1
Chen, JG1
Ramirez, J1
Benhenneda, R1
Letissier, H1
Dubrana, F1
Di Francia, R1
Meunier, V1
Mares, O1
Gricourt, Y1
Simon, N1
Kouyoumdjian, P1
Cuvillon, P1
Spence, JD1
Grosser, T1
FitzGerald, GA1
Zhang, J1
Zhai, X1
Wang, L1
Tong, H1
Xian, T1
Shao, L1
Paschoal, NOS1
Natour, J1
Machado, FS1
Oliveira, HAV1
Fernandes, ADRC1
Furtado, RNV1
Gong, JJ1
Chen, CC1
Lebaron, J1
Chary, MA1
Brant, A1
Lewicki, P1
Johnson, JP1
Weinstein, IC1
Bowman, A1
Sze, C1
Shoag, JE1
Fallon, M1
Dierberger, K1
Leng, M1
Hall, PS1
Allende, S1
Sabar, R1
Verastegui, E1
Gordon, D1
Grant, L1
Lee, R1
McWillams, K1
Murray, GD1
Norris, L1
Reid, C1
Sande, TA1
Caraceni, A2
Kaasa, S1
Laird, BJA1
Wang, Y2
Fan, M1
Wang, H1
You, Y1
Wei, C1
Liu, M1
Luo, A1
Xu, X1
Duan, X1
Mabaso, LMN1
Bhettay, A1
Bandini, R1
Demopoulos, D1
Turgut, K1
Yavuz, E1
Gülaçtı, U1
Aydın, İ1
Sönmez, C1
Aktaş, N1
Arslan, E1
Altarifi, AA1
Younis, BA1
Nuseir, KQ1
Al-Mousa, AA1
Qaoud, AK1
Alsalem, MI1
Neubert, JK1
Wadström, MG1
Hailer, YD1
Li, W3
Zhang, X3
Han, J3
Falise, AM2
Sharma, V2
Hoeflich, CC2
Lopez-Quintero, C2
Striley, CW2
Helvik, AS3
Bergh, S3
Kabukcuoğlu, K1
Šaltytė Benth, J3
Lichtwarck, B1
Husebø, B2
Tevik, K3
Weng, Q1
Goh, SL1
Wu, J2
Persson, MSM2
Wei, J2
Sarmanova, A1
Li, X1
Hall, M1
Doherty, M4
Jiang, T1
Zeng, C2
Lei, G2
Zhang, W3
Ben Othman, A1
Ben Ali, R1
Ben Akacha, A1
El May, MV1
Burghle, A1
Pottegård, A1
Rasmussen, M1
Bruun, B1
Roost Hosbjerg, J1
Lundby, C1
Sun, CK1
Tsai, TH1
Desomer, L1
Tate, DJ1
Pillay, L1
Awadie, H1
Sidhu, M1
Ahlenstiel, G1
Bourke, MJ1
Resnick, B1
Boltz, M1
Galik, E1
Ellis, J1
Kuzmik, A1
Drazich, B1
McPherson, R1
Kim, E1
Mohanty, CR1
Gupta, A1
Gupta, N1
Radhakrishnan, RV1
Dersch-Mills, D1
Howlett, A1
Lind, J1
Marchuk, A1
Mohammad, K1
Zempsky, W1
Bell, J1
Mossali, VM1
Kachroo, P1
Siddiqui, K1
Ricci, C1
Albanese, CM1
Pablo, LA1
Li, J3
Fatima, M1
Barrett, K1
Levis, B1
Brown, HK1
Jelsone-Swain, L1
McCommon, SA1
Turk, B1
Roach, A1
Shykhveisi, F1
Jafarian Amiri, R1
Zabihi, A1
Haghshenas Mojaveri, M1
Arzani, A1
Chehrazi, M1
Chari, ZV1
Zullo, F1
Di Mascio, D1
Berghella, V1
Dowd, LA1
Cross, AJ1
Liau, SJ1
Jadczak, AD1
Visvanathan, R2
Veal, FC2
Bell, JS2
Cetira-Filho, EL1
Martins-Filho, PR1
de Barros Silva, PG1
da Hora Sales, PH1
Vieira, AF1
Sindeaux, LME1
Dos Anjos, MO1
Leão, JC1
Costa, FWG1
Sato, S1
Tomitori, H1
Okawa, A1
Akano, K1
Brandelli, YN1
Chambers, CT2
Mackinnon, SP1
Parker, JA2
Huber, AM1
Stinson, JN2
Wildeboer, EM1
Wilson, JP1
Piccolo, O1
Haslund-Krog, S1
Barry, JM1
Birnbaum, AK1
Dalhoff, K1
Brink Henriksen, T1
Sherwin, CMT1
Avachat, C1
Poulsen, S1
Christensen, U1
Remmel, RP1
Wilkins, D2
van den Anker, JN9
Holst, H1
Goyal, B1
Bishnoi, S1
Parveen, S1
Patel, D1
Yasmeen, -1
Tarekar, A1
Stróżyk, A1
Paraskevas, T1
Romantsik, O1
Calevo, MG1
Banzi, R1
Ley, D1
Bruschettini, M1
Stamenkovic, D1
Baumbach, P1
Radovanovic, D1
Novovic, M1
Ladjevic, N1
Dubljanin Raspopovic, E1
Palibrk, I1
Unic-Stojanovic, D1
Jukic, A1
Jankovic, R1
Bojic, S1
Gacic, J1
Stamer, UM1
Meissner, W1
Zaslansky, R1
de Sévaux, JLH1
Damoiseaux, RA2
van de Pol, AC2
Lutje, V1
Hay, AD2
Little, P2
Schilder, AG2
Venekamp, RP2
Shah, PS4
Torgalkar, R1
Shah, VS1
Shabbir, M1
Bugayong, ML1
DeVita, MA1
Zambelli, VO1
Gross, ER1
Harris, E1
Huang, Y1
Meng, L1
Zhou, R1
Luo, F1
Borza, T1
Milani, GP1
Mercante, A1
Cattaneo, D1
Alberti, I1
Agostoni, C1
Benini, F1
Carabot, F1
Donat-Vargas, C1
Santoma-Vilaclara, J1
Ortega, MA1
García-Montero, C1
Fraile-Martínez, O1
Zaragoza, C1
Monserrat, J1
Alvarez-Mon, M1
Alvarez-Mon, MA1
Mahmoud, AM1
Allam, AR1
Strickmann, B1
Deicke, M1
Hoyer, A1
Kobiella, A1
Jansen, G1
Sodeifian, G1
Garlapati, C1
Arbab Nooshabadi, M1
Razmimanesh, F1
Roshanghias, A1
Connolly, KP1
Kleinman, RS1
Stevenson, KL1
Neuman, MD1
Mehta, SN1
Poblete, P1
Aranda, N1
Varrassi, G1
Alon, E1
Bagnasco, M1
Lanata, L1
Mayoral-Rojals, V1
Paladini, A1
Pergolizzi, JV3
Perrot, S2
Scarpignato, C1
Tölle, T1
Abdelrahman, I1
Steinvall, I1
Elmasry, M1
Sjoberg, F1
Nogrady, B1
Monteiro, B1
Steagall, PV1
Saibudeen, A1
Makris, GC1
Elzein, A1
Wigham, A1
Patel, R1
Husainy, MA1
Anthony, S1
Uberoi, R1
Margan Koletic, Z1
Dosenovic, S1
Puljak, L1
Donato, J1
Rao, K1
Lewis, T1
Bandoli, G2
Palmsten, K1
Chambers, C2
Kaklamanos, EG2
Makrygiannakis, MA2
Athanasiou, AE2
Jukic, AMZ1
Padiyara, P1
Bracken, MB1
McConnaughey, DR1
Steiner, AZ1
Alonso-Castro, AJ3
Zapata-Morales, JR3
Solorio-Alvarado, C1
Hernández-Santiago, A1
Espinoza-Ramírez, LA1
Carranza-Álvarez, C1
Ramadoss, V1
Sørensen, AMS1
Tarp, S1
Johannsen, P1
Lolk, A1
Bandak, E1
Pedersen, H1
Saxtrup, N1
Kallehauge, H1
Solem, EJ1
Christensen, MB1
Banks, C1
Hughes, K1
Simpkins, C1
Elliott, DP1
Hagen, M1
Alchin, J1
Ersek, M1
Nash, PV1
Hilgeman, MM1
Neradilek, MB1
Herr, KA1
Block, PR1
Collins, AN1
Saragiotto, BT1
Abdel Shaheed, C2
Maher, CG2
Ohlsson, A4
Pape, S1
Gevers, TJG1
Drenth, JPH1
Vernant, M1
Lepoupet, M1
Creveuil, C1
Alix, A1
Gourio, C1
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Lelong-Boulouard, V1
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Braithwaite, I2
McKinlay, CJD1
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Ejsmont, A1
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Clinical Trials (145)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prophylactic Pregabalin to Decrease Pain During Medical Abortion: a Randomized Controlled Trial[NCT02782169]Phase 4110 participants (Actual)Interventional2015-06-30Completed
PAIN CONTROL IN FIRST TRIMESTER MEDICAL ABORTION: A Randomized Trial[NCT01457521]Phase 4250 participants (Actual)Interventional2011-10-31Completed
The Effect of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion: A Double-blind Randomized Placebo Controlled Study[NCT00997074]Phase 361 participants (Actual)Interventional2009-10-31Completed
Paravertebral Block Versus Simultaneous Ketamine and Lidocaine Infusions for Pain Management in Rib Fracture Patients[NCT04413799]Early Phase 1170 participants (Anticipated)Interventional2020-09-01Recruiting
Paracetamol Route in Palliative Care Patients : Intravenous Versus Subcutaneous Route Pharmacokinetics, Study Protocol for a Randomized Equivalence Pilot Trial[NCT03944044]20 participants (Anticipated)Interventional2019-07-15Recruiting
A Randomized, Double-Blind, 7-Day Study of the Efficacy and Safety of Rofecoxib Versus Placebo and Diclofenac in Patients With Acute Painful Rotator Cuff Syndrome[NCT00140933]Phase 3274 participants Interventional2003-04-30Terminated
Efficacy and Security of Combined Analgesia (Opioid and Anti-inflammatory Agent) to Control Pain in Children Seen in the Emergency Department for a Trauma of a Limb[NCT01189773]Phase 4200 participants (Actual)Interventional2008-02-29Completed
An Open Label Randomized Multicenter Comparative Study On Celecoxib Efficacy And Safety Versus Non-Selective NSAID In Acute Pain Due To Ankle Sprain[NCT00446797]Phase 4278 participants (Actual)Interventional2007-05-31Completed
Ibuprofen Versus Acetaminophen vs Their Combination in the Relief of Musculoskeletal Pain in the Emergency Setting[NCT01827475]Phase 290 participants (Actual)Interventional2010-07-31Completed
The Efficacy and Safety of Administration of the COX-2 Selective NSAID, Etoricoxib (120mg od. for 7 Days) Compared to Diclofenac (50 mg Tds. for 7 Days) and Placebo as Adjunct Treatment in the First 7 Days of Treatment of Acute Grade II Lateral Ankle Liga[NCT00954785]Phase 40 participants (Actual)Interventional2009-11-30Withdrawn (stopped due to The study was terminated by Merck USA. The company did not supply drugs for the study.)
An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995]Phase 130 participants (Anticipated)Interventional2023-09-13Recruiting
Pharmacogenomics of APAP Induced DILI in Chinese Population.[NCT04964310]339 participants (Anticipated)Observational2020-08-31Recruiting
Battlefield Auricular Acupuncture for Control of Post-partum Pain[NCT02526186]90 participants (Actual)Interventional2016-02-29Completed
CRAMPS Trial: Controlled Randomized Trial Assessing Maternal Post-partum Pain With Suppositories[NCT01271855]Phase 4100 participants (Actual)Interventional2009-07-22Completed
Comparison Between 2 Pain Analgesic Protocols Following Vaginal Delivery[NCT04087317]220 participants (Anticipated)Interventional2019-09-01Not yet recruiting
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery: A Prospective Double Blind Randomized Control Trial[NCT04017442]Phase 4140 participants (Actual)Interventional2019-10-19Completed
Post-partum Non-pharmacologic Pain Management[NCT03903172]130 participants (Anticipated)Interventional2019-06-01Enrolling by invitation
Effect of Foot Massage on Postpartum Comfort and Pain Level of the Mothers Who Had Vaginal Birth: A Randomised Controlled Trial[NCT04037202]66 participants (Actual)Interventional2017-07-03Completed
EFFICACY OF GINGER EXTRACT ON PAIN RELIEF FOR FIRST NORMAL POSTPARTUM WOMEN[NCT03617900]Phase 1/Phase 299 participants (Actual)Interventional2018-08-29Completed
Dental Support Device During Breastfeeding as a Mean for Pain Control[NCT02399774]Phase 31,500 participants (Anticipated)Interventional2015-05-31Not yet recruiting
Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment[NCT05986513]66 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Cost-effectiveness Analysis of Oral Paracetamol and Ibuprofen for Treating Pain After Soft Tissue Limb Injuries: Double-blind, Randomised Controlled Trial[NCT00528658]Phase 2782 participants (Actual)Interventional2005-01-31Completed
Effective Strategy to Cope the Pain and Discomfort Among Women Undergoing Mammography[NCT04381104]632 participants (Anticipated)Interventional2019-11-21Recruiting
Tolerance and Efficiency of Paracetamol bu Subcutaneous Releasing in Patients Hospitalized Into Palliative Care[NCT02884609]160 participants (Actual)Observational2014-08-31Completed
Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery[NCT02573922]Phase 4180 participants (Actual)Interventional2012-05-31Completed
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Full-Factorial, Parallel-Group Study Evaluating Safety and Efficacy of Naltrexone-Acetaminophen Combination in Acute Migraine Treatment in Adults, With Exploratory Focus on Co-Occurring[NCT05685225]Phase 2300 participants (Anticipated)Interventional2024-03-01Not yet recruiting
Clinical Evaluation of the Effectiveness of Different Methods in Reducing Pain During Debonding of Orthodontic Fixed Appliance: a Randomized Clinical Trial[NCT05904587]128 participants (Anticipated)Interventional2023-03-19Recruiting
Haemodynamic Effects of Paracetamol (Acetaminophen) as Extended Intravenous Infusion Versus Intravenous Bolus in Septic Shock Patients[NCT06076980]Phase 461 participants (Actual)Interventional2020-11-01Completed
Non - Opioid Treatments (Single Administration) for Pain During the Early Postpartum Period After Vaginal Delivery[NCT04653506]1,000 participants (Anticipated)Interventional2020-11-28Recruiting
A Single Blinded, Open-labelled, Randomized Control Trial Comparing Acetaminophen Rectal Suppository With Diclofenac Rectal Suppository as Analgesia for Perineal Injury Following Childbirth[NCT03041779]Phase 2909 participants (Actual)Interventional2015-10-31Completed
The Impact of Pain on Behavioural Disturbances in Patients With Moderate and Severe Dementia. A Cluster Randomized Trial[NCT01021696]Phase 2/Phase 3352 participants (Actual)Interventional2009-11-30Completed
A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041]Phase 3248 participants (Actual)Interventional2007-08-31Completed
Air as a Placebo: Increasing the Respiratory Performance of People With COPD Through Simple Expectations of Improvement. An Experimental, Randomised, Two-arm, Counterbalanced Study With Three Data Collection Sessions.[NCT05218564]102 participants (Anticipated)Interventional2020-02-19Recruiting
Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial[NCT05891132]60 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Ultrasound Guided Central Line Insertion in Neonates: Pain Score Results From a Prospective Study[NCT03647293]61 participants (Actual)Interventional2016-11-30Completed
[NCT01947205]111 participants (Actual)Interventional2012-11-30Completed
Percutaneous Pin Removal in the Outpatient Clinic - do Children Require Analgesia? A Randomized Controlled Trial[NCT01944085]240 participants (Actual)Interventional2008-10-31Completed
A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Acetaminophen Extended Release (3900 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee.[NCT00240799]Phase 3542 participants (Actual)InterventionalCompleted
Pilot, Open Non-controled Trial to Assess the Feasibility of Implementing Objective Parameters as Primary Endpoints in a Clinical Trial With Patients Affected by Knee Osteoarthritis[NCT03421054]8 participants (Actual)Interventional2018-03-19Completed
Double Blind, Placebo Controlled Trial to Evaluate the Effects of a Nutraceutical Containing High-Molecular-Weight Hyaluronic Acid (HA) and Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) in Patients Affected by Knee Osteoarthritis[NCT03612986]72 participants (Actual)Interventional2018-08-22Completed
Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial[NCT00652093]Phase 424 participants (Actual)Interventional2008-03-31Terminated (stopped due to Removal of Darvocet from US market)
Use of Intravenous Acetaminophen in Adolescents and Pediatrics Undergoing Spinal Fusion Surgery: Randomized Controlled Trial[NCT04959591]Phase 399 participants (Actual)Interventional2021-06-01Completed
Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI[NCT01562704]Phase 121 participants (Actual)Interventional2012-01-31Completed
Therapeutic Effect of Inexpensive, Flexible and Non-heeled Footwear on the Clinical, Functional and Gait Biomechanics in Elderly Women With Knee Osteoarthritis: a Randomized Clinical Trial[NCT01342458]Phase 156 participants (Actual)Interventional2011-03-31Completed
Extremely Low Gestational Age Infants' Paracetamol Study: a Randomized Trial[NCT03641209]Phase 1/Phase 240 participants (Actual)Interventional2018-09-03Active, not recruiting
Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus of Preterm Infants - Randomised, Placebo-controlled Multicentre Trial[NCT03648437]Phase 160 participants (Anticipated)Interventional2018-09-03Recruiting
Comparison of the Effects of Ibuprofen and Low-Level Laser Therapy on Orthodontic Pain By Means of Interleukin 1-Beta and Substance P Levels in the Gingival Crevicular Fluid[NCT04070001]60 participants (Actual)Interventional2017-08-01Completed
Battlefield Acupuncture to Treat Pain in Hidradenitis Suppurativa[NCT04218422]32 participants (Anticipated)Interventional2020-01-22Recruiting
A Phase 3, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Fixed-Dose, Parallel-Group, Efficacy, and Safety Study of Meloxicam SoluMatrix™ Capsules in Patients With Pain Due to Osteoarthritis of the Knee or Hip[NCT01787188]Phase 3403 participants (Actual)Interventional2013-02-28Completed
The Effect of Chronic Pain Relief Over Knee Joint Area by Gua Sha Therapy[NCT03821194]40 participants (Anticipated)Interventional2019-01-25Recruiting
[NCT01993589]144 participants (Actual)Interventional2012-11-30Completed
A Randomized, Comparison Study of L.M.X.4 Cream Versus J-Tip Needle-Free Injection System With Lidocaine in Children Undergoing In-Office Percutaneous Achilles Tenotomy for Clubfoot[NCT04766684]Phase 494 participants (Anticipated)Interventional2021-06-01Recruiting
Dexmedetomidine for LISA Procedure in Preterm Infants: a Pilot Study[NCT04820101]40 participants (Anticipated)Interventional2021-05-15Not yet recruiting
Maternal Involvement in Pain Management in NICU: a Randomized Controlled Trial[NCT04883944]50 participants (Actual)Interventional2021-05-17Completed
40% Orally Administered Dextrose Gel is More Effective Than 25% Dextrose But Not Sufficiently Reliefs Acute Pain in Term Neonates: A Randomized Controlled Trial[NCT02984098]Phase 4200 participants (Actual)Interventional2014-09-30Completed
The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electromyography in Pediatric Population-A Randomized Controlled Trial[NCT04337814]113 participants (Actual)Interventional2019-12-30Completed
Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics[NCT02417337]Phase 2170 participants (Actual)Interventional2012-08-31Completed
Effect of Preoperative, Single-dose Diclofenac Potassium on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double Blind Randomized Controlled Trial[NCT03341260]Phase 2/Phase 370 participants (Actual)Interventional2016-12-31Completed
The Copenhagen Analgesic Study[NCT04369222]600 participants (Anticipated)Observational2020-03-01Recruiting
Childrens' Experiences of Pain in Conjunction With Tooth Extraction - a Grounded Theory[NCT04064853]12 participants (Actual)Observational2019-04-05Completed
Comparison of Pre-emptive Ibuprofen, Acetaminophen, and Placebo Administration in Reducing Local Anesthesia Injection Pain and Post-operative Pain in Primary Tooth Extraction. A Clinical Study[NCT03786029]Phase 2/Phase 366 participants (Actual)Interventional2019-04-01Completed
Effect of Preoperative Administration of Ibuprofen in Children Undergoing Extraction for Reducing Postoperative Pain: A Double-blind Randomized Controlled Clinical Trial[NCT04476069]Phase 356 participants (Actual)Interventional2019-01-10Completed
Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319]Phase 3300 participants (Actual)Interventional2013-02-28Completed
Use of Atorvastatin (Lipitor) to Prevent Bone Pain Following Infusion of Pamidronate or Zoledronic Acid[NCT00120133]12 participants (Actual)Interventional2004-12-31Completed
Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678]Phase 40 participants (Actual)Interventional2014-02-28Withdrawn (stopped due to Investigator left institution)
A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755]62 participants (Actual)Interventional2017-07-01Completed
Randomized Double-blind Controlled Study to Assess the Efficacy of Intravenous Acetaminophen Associated With Strong Opioids in the Management of Acute Pain in Adult Cancer Patients[NCT04779567]Phase 4112 participants (Actual)Interventional2019-06-10Completed
Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement: a Randomized Controlled Trial[NCT03568721]Phase 481 participants (Actual)Interventional2015-01-25Completed
The Effect of the Chewing Gum in Alleviating Orthodontic Pain After Separator and Initial Arch Wire Placement: A Randomized Clinical Trial[NCT04836234]108 participants (Anticipated)Interventional2019-03-06Recruiting
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain of Initial Orthodontic Wire Insertion: a Randomized Controlled Trial[NCT04059172]Early Phase 1375 participants (Anticipated)Interventional2019-12-10Recruiting
Double-blind, Randomized, Placebo-controlled Study on the Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing Intrauterine System[NCT02799641]61 participants (Actual)Interventional2016-07-31Completed
Comparison of Analgesic Efficacy of Dexketoprofen and Ibuprofen in Long Bone Fractures: Randomised Controlled Double-blind Study[NCT06060236]Phase 4100 participants (Anticipated)Interventional2023-09-01Recruiting
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136]Phase 484 participants (Actual)Interventional2011-01-31Completed
Ibuprofen vs. Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?[NCT01605240]50 participants (Anticipated)Interventional2012-07-31Recruiting
The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510]Phase 4200 participants (Actual)Interventional2011-04-30Completed
[NCT01773044]Phase 4300 participants (Actual)Interventional2012-09-30Completed
"Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623]300 participants (Actual)Interventional2016-09-30Completed
A Randomized Clinical Trial of Buzzy Versus Vapocoolant in Pain Relief During Phlebotomy and IV Catheterization in the Pediatric ED[NCT06182631]Phase 3176 participants (Actual)Interventional2019-07-15Completed
Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis[NCT00666523]81 participants (Actual)Interventional2007-01-31Completed
A Double-Blind, Placebo-Controlled, 3-Period Crossover Study to Evaluate the Analgesic Effects of Naproxen and Ultracet in a Walking Model of Osteoarthritis Knee Pain[NCT00772967]Phase 122 participants (Actual)Interventional2008-06-30Completed
A Randomized, Placebo-Controlled Single-Dose 3-Period Crossover Study to Assess the Tolerability and Efficacy of Ibuprofen 800 mg in a Walking Model of Osteoarthritis Pain[NCT00565084]Phase 133 participants (Actual)Interventional2007-03-31Completed
Impact of Intrathecal Dexamethasone Administration for Elderly Patients With Proximal Femoral Fracture[NCT03856502]60 participants (Actual)Interventional2012-11-11Completed
Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239]Phase 410 participants (Actual)Interventional2015-05-31Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).)
Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699]Phase 441 participants (Actual)Interventional2013-09-30Completed
Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001]Phase 460 participants (Actual)Interventional2015-01-31Completed
A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574]Phase 3440 participants (Anticipated)Interventional2023-05-22Recruiting
A Clinical Trial to Assess a Single Dose of Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine[NCT03061734]Phase 292 participants (Actual)Interventional2017-02-18Completed
Acetaminophen and Social Pain in Borderline Personality Disorder[NCT02108990]Phase 29 participants (Actual)Interventional2013-09-30Completed
Confirmatory Efficacy and Safety Study of the Fixed-dose Combination of Etoricoxib / Tramadol Versus Acetaminophen / Tramadol for the Management of Acute Low Back Pain.[NCT04968158]Phase 3124 participants (Actual)Interventional2021-11-29Completed
The Effect of Lokal Cold Application in Nitroglycerin-Induced Headache[NCT04707586]70 participants (Anticipated)Interventional2020-12-15Recruiting
Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040]121 participants (Actual)Interventional2021-09-01Completed
Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries[NCT04199572]Phase 4162 participants (Actual)Interventional2022-10-16Completed
A Double Blind, Multi-arm Randomized Control Trial, for Efficacy of Intramuscular Diclofenac Versus Intravenous Morphine Versus Intravenous Paracetamol, in Renal Colic Emergency Department Pain Management[NCT02187614]Phase 41,645 participants (Actual)Interventional2014-08-31Completed
[NCT01833728]16 participants (Actual)Interventional2013-04-30Completed
Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial.[NCT02056223]Phase 2/Phase 3120 participants (Anticipated)Interventional2017-01-09Suspended (stopped due to We enrolled only 53 patients)
Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?[NCT00488540]Phase 4280 participants (Anticipated)Interventional2007-06-30Completed
Disposition of Intravenous Paracetamol in Young Women, Including During Pregnancy, in Postpartum or When on Oral Contraceptives[NCT02590900]69 participants (Actual)Observational2010-06-30Completed
Preoperative Cesarean Section Intravenous Acetaminophen and Postoperative Pain Control: A Blinded Randomized Placebo-Controlled Trial[NCT02694653]Phase 1200 participants (Anticipated)Interventional2014-10-31Enrolling by invitation
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
A Randomized, Double-Blinded, Placebo Controlled Trial Using Single Dose Dexmedetomidine In The Treatment Of Pain In Patients Undergoing Cleft Palate Repair[NCT02915042]Phase 40 participants (Actual)Interventional2017-12-31Withdrawn (stopped due to Recruitment concerns)
Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716]600 participants (Anticipated)Interventional2018-07-06Enrolling by invitation
Predicting Perioperative Opioid Adverse Effects and Personalizing Analgesia in Children: A Multicenter Pharmacogenetic Study[NCT01495611]1,000 participants (Actual)Observational2010-11-30Completed
A Randomized, Crossover, Pilot Trial of the Feasibility and Safety of Acupoint Injection of Vitamin K for Treatment of Primary Dysmenorrhea[NCT00995917]18 participants (Actual)Interventional2009-10-31Completed
PINPOINT: Gaming Technology to Engage Adolescent Sickle Cell Patients in Precision Pain Management[NCT03291613]13 participants (Actual)Interventional2017-01-15Completed
Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029]220 participants (Actual)Interventional2014-09-30Completed
Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313]152 participants (Actual)Interventional2015-03-31Active, not recruiting
A Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled Study to Evaluate the Efficacy of Rofecoxib and a Dosing Regimen of Oxycodone With Acetaminophen Over 24 Hours in Patients With Postoperative Dental Pain[NCT00092313]Phase 3271 participants (Actual)Interventional2002-06-30Completed
Efficacy Evaluation of Intra-articular Hyaluronic Acid (Sinovial®) vs Synvisc® in the Treatment of Symptomatic Knee Osteoarthritis. A Double-blind, Controlled, Randomised, Parallel-group Non-inferiority Study[NCT00556608]Phase 4381 participants (Actual)Interventional2007-11-30Completed
A Trial of Prednisone and Acetaminophen Versus Acetaminophen Alone in Minimizing Flu-like Symptoms From Pegylated Interferon Beta-1a[NCT03424733]Phase 450 participants (Anticipated)Interventional2017-09-25Recruiting
Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study[NCT00525967]Phase 2/Phase 350 participants (Anticipated)Interventional2006-02-28Recruiting
The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded C[NCT04804761]20 participants (Anticipated)Interventional2023-01-01Recruiting
Effectiveness of a Combined Acetaminophen and Ibuprofen Regimen for Management of Post-Tonsillectomy Pain in Pediatric Patients[NCT04551196]Phase 347 participants (Actual)Interventional2020-09-28Completed
Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567]42 participants (Actual)Interventional2021-03-12Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.)
Double Blinded Study Ondansetron's Opposite Effect on Postoperative Analgesia of Acetaminophen[NCT02296333]Phase 480 participants (Actual)Interventional2014-05-31Completed
Comparison of Tramadol vs. Tramadol With Paracetamol for Efficacy of Postoperative Pain Management in Lumbar Discectomy: A Randomised Controlled Trial[NCT03482492]60 participants (Actual)Interventional2014-03-20Completed
Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093]Phase 366 participants (Actual)Interventional2009-06-30Completed
Analgesia Efficacy of Pre-operative and Post-operative PEC I/II Block for Bilateral Mastectomy With Reconstruction[NCT03653988]35 participants (Actual)Interventional2019-03-12Completed
Comparison Between Serratus Anterior Plane Block, and Transversus Thoracic Plane Block Combined With Serratus Anterior Plane Block, for the Management of Post-mastecomy Pain.[NCT04375111]54 participants (Actual)Interventional2021-06-15Completed
Efficacy of Pregabalin and Duloxetine in Patients With Painful Diabetic Peripheral Neuropathy (PDPN): the Effect of Pain on Cognitive Function, Sleep and Quality of Life (BLOSSOM)[NCT04246619]Phase 4254 participants (Actual)Interventional2019-11-12Terminated (stopped due to The statistical analysis will still provide relevant results with the same statistical power as initially planned.COVID-19 pandemic prolonged the recruiting period and consequently affected the costs of the clinical trial.)
Phase III Clinical Trial Studying Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children[NCT02477007]Phase 3304 participants (Actual)Interventional2015-12-03Completed
Effective Analgesia Using the 5 S's During Routine Immunizations at 2 and 4 Months[NCT01368861]230 participants (Actual)Observational2010-06-30Completed
Childhood Immunization: Reducing Immunization Distress (RID) Using Multi-Modal Distraction[NCT01379885]77 participants (Actual)Interventional2011-06-30Terminated (stopped due to Estimated sample size not achieved due to decline in number of eligible patients and difficulty recruiting and retaining research staff.)
Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500]160 participants (Actual)Interventional2013-05-31Completed
Self-compression Mammography in Clinical Practice: A Randomized Clinical Trial Compared to Standard Compression Mammography[NCT04009278]502 participants (Actual)Interventional2018-01-25Completed
Clinical Response of Nuberol Forte® for the Pain Management in Musculoskeletal Disorders in Routine Pakistani Practice[NCT04765787]399 participants (Actual)Observational2020-11-25Completed
Effectiveness of Percutaneous Microelectrolysis in the Decrease of Pain in Myofascial Trigger Points: Evaluation Through Algometry and Visual Analog Scale. Randomized Controlled Trial.[NCT03636386]48 participants (Actual)Interventional2018-05-23Completed
MiniTightRope Suspensionplasty Compared With Ligamentous Reconstruction Tendon Interposition for the Treatment of Basilar Thumb Arthritis. A Randomized Clinical Trial[NCT02591368]7 participants (Actual)Interventional2015-10-31Terminated
Arthroscopic Surgery Versus Non-surgical Treatment of Osteoarthritis of the Knee[NCT00158431]Phase 3186 participants (Actual)Interventional1999-01-31Completed
Analgesic Effect of Ibuprofen 400 mg/Paracetamol 1000 mg, Ibuprofen 400 mg/ Paracetamol 1000 mg/60 mg Codeine, and Paracetamol 1000 mg/Codeine 60 mg: A Single-dose, Randomized, Placebo-controlled and Double-blind Study[NCT00921700]Phase 4200 participants (Actual)Interventional2009-06-30Completed
A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226]Phase 431 participants (Actual)Interventional2023-04-01Completed
Effect of Massage Therapy on Preoperative Anxiety and Postoperative Pain in Cancer Patients Undergoing Port Implantation[NCT00991770]Phase 160 participants (Actual)Interventional2009-02-28Completed
Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547]Phase 20 participants (Actual)Interventional2016-07-14Withdrawn (stopped due to Lack of human ressources)
The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee[NCT00752765]30 participants (Anticipated)Observational2008-09-30Completed
Pause and Breathe: Online Self-Help Mindfulness-Based Intervention: Investigation of Its Efficacy and Mechanism of Change[NCT05678972]939 participants (Actual)Interventional2023-01-01Completed
Post-Operative Kinesio Taping Impact on Pain in Thoracotomy vs Thoracoscopy[NCT05200689]310 participants (Anticipated)Interventional2022-01-09Recruiting
Stentless Florence Robotic Intracorporeal Neobladder (FloRIN)[NCT05891535]63 participants (Anticipated)Interventional2021-01-01Recruiting
A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887]Phase 2150 participants (Actual)Interventional2004-10-31Completed
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722772]60 participants (Anticipated)Interventional2016-02-29Recruiting
Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722811]60 participants (Anticipated)Interventional2016-02-29Recruiting
Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721]Phase 2/Phase 350 participants (Actual)Interventional2015-07-31Completed
Inhaled Glucocorticoids for Acute Pharyngitis: A Randomized Clinical Trial[NCT04027322]Phase 2/Phase 3200 participants (Actual)Interventional2019-06-01Completed
Impact of Direct Current Neuromuscular Electrical Stimulation on Physical Therapy Treatment of Peripheral Neuropathy[NCT05442021]148 participants (Actual)Interventional2022-08-01Completed
The E-STIM Trial: A Randomized, Double-Blind, Multicenter Trial Comparing the Efficacy of the Empi Select Transcutaneous Electrical Nerve Stimulation (TENS) to a Control for the Treatment of Chronic Lower Back Pain[NCT00709748]300 participants (Anticipated)Interventional2008-02-29Recruiting
Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery - an Exploratory Placebo-controlled Clinical Study to Investigate the Analgesic Properties of the Combination of Diclofenac [NCT03493490]Phase 472 participants (Actual)Interventional2018-03-01Completed
Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544]76 participants (Actual)Interventional2019-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maximum Pain Score Over Study Period

reported on an 11-point numerical rating scale (NRS 0-10) where 0 indicates no pain and 10 indicates the most severe pain (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

Interventionunits on a scale (Mean)
Pregabalin5.0
Placebo5.5

Number of Ibuprofen 800mg Tablets Used

summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

Interventiontablets (Median)
Pregabalin1
Placebo2

Number of Oxycodone/Acetominophen Tablets (5/325mg) Used

summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

Interventiontablets (Median)
Pregabalin0
Placebo0.5

Number of Participants Ever Experiencing Different Symptoms During Abortion

A participant was included once if they ever reported a symptom during the 72 hour study period, not reflective of how long the symptom lasted. These were all commonly reported side effects during previous research on medication abortions and commonly reported side effects of pregabalin, so they were not included as adverse events. (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

,
Interventionparticipants (Number)
NauseaVomitingSleepinessDizzinessHeadacheBlurred VisionDiarrheaConstipationDry Mouth
Placebo42303926177291525
Pregabalin43284745281528622

11-point Visual Analog Scale for Pain

Participant pain was assessed using an 11-point Visual Analog Scale for Pain. Scores ranged from 0 (no pain) to 10 (worst pain possible) (NCT01457521)
Timeframe: 1-2 weeks

Interventionunits on a scale (Mean)
Prophylactic7.1
Therapeutic7.3

Change From Baseline at Day 3 in Pain Visual Analog Scale (VAS) - Per Protocol Population

"Assessment of ankle pain by VAS: 100 mm horizontal line with left end being No Pain & right end being Worst Possible Pain. Participants drew vertical line on horizontal scale to best reflect current pain on full weight bearing of injured ankle. Distance from left end of line to mark. Change: mean score at day 3 minus mean score at baseline" (NCT00446797)
Timeframe: Baseline and day 3

Interventionscores on a scale (Mean)
Celecoxib-44.88
nsNSAIDs-40.76

Change From Baseline in Pain Visual Analog Scale (VAS) - Modified Intent to Treat Population

"Assessment of ankle pain by VAS: 100 mm horizontal line, left end being No Pain & right end being Worst Possible Pain. Participants drew vertical line on horizontal scale to best reflect current pain on full weight bearing of injured ankle. Distance from left end of line to mark. Change: mean score at observation minus mean score at baseline" (NCT00446797)
Timeframe: Baseline and days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2Day 3Day 7
Celecoxib-29.25-44.87-61.17
nsNSAIDs-25.98-40.75-57.89

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Index

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~The pain interference index is the average of pain interference questions 5A to 5G. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib4.072.791.28
nsNSAIDs4.012.831.33

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5A

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5A: Subject response to 'how, during the past 24 hours, pain has interfered with your general activity. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib5.403.651.78
nsNSAIDs5.374.071.90

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5B

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5B: Subject response to 'how, during the past 24 hours, pain has interfered with your mood'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib3.722.431.17
nsNSAIDs3.642.381.26

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5C

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5C: Subject response to 'how, during the past 24 hours, pain has interfered with your walking ability'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib5.103.581.65
nsNSAIDs5.113.691.62

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5D

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5D: Subject response to 'how, during the past 24 hours, pain has interfered with your normal work (work outside the home and housework)'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib5.294.041.84
nsNSAIDs5.394.041.87

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5E

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5E: Subject response to 'how, during the past 24 hours, pain has interfered with your relations with other people'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib2.701.810.80
nsNSAIDs2.671.690.78

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5F

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5F: Subject response to 'how, during the past 24 hours, pain has interfered with your sleep'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib2.971.900.68
nsNSAIDs2.871.860.82

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Interference Question 5G

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5G: Subject response to 'how, during the past 24 hours, pain has interfered with your enjoyment of life'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib3.332.131.07
nsNSAIDs2.992.061.10

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Index

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Pain severity index is the average of the pain severity questions 1 to 4. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib4.242.841.37
nsNSAIDs4.483.261.68

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 1

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q1: Subject response to 'describe your pain at its worst in the last 24 hours'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 1, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib5.713.812.08
nsNSAIDs5.904.442.38

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 2

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q2: Subject response to 'describe your pain at its least in the last 24 hours'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 133, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib3.252.070.83
nsNSAIDs3.362.401.16

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 3

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q3: Subject response to 'describe your pain on the average'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N = 135, 131)Day 7 (N = 133, 125)
Celecoxib4.342.901.41
nsNSAIDs4.413.261.74

Modified Brief Pain Inventory Short Form (m-BPI-sf) - Pain Severity Question 4

"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q4: Subject response to 'how much pain you have right now'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionscores on a scale (Mean)
Day 2 (N = 134, 133)Day 3 (N =135, 131)Day 7 (N = 133, 125)
Celecoxib3.642.581.14
nsNSAIDs4.232.921.43

Number of Subjects Responding (Improving) - MITT Population

The number of subjects showing a response: a decrease of at least 20 mm (that is improvement) on the pain visual analog scale (VAS) scale (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionparticipants (Number)
Day 2 - response (N=134, 133)Day 2 - no responseDay 3 - response (N=135, 131)Day 3 - no responseDay 7 - response (N=133, 125)Day 7 - no response
Celecoxib9143124111294
nsNSAIDs7954116151205

Pain Relief - MITT Population

"Subject's response to the statement My relief from starting pain is. Scale from 0 = None to 4 = Complete." (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionparticipants (Number)
Day 2 - None (N=135, 132)Day 2 - A littleDay 2 - SomeDay 2 - A lotDay 2 -CompleteDay 3 - None (N=135, 131)Day 3 - A littleDay 3 - SomeDay 3 - A lotDay 3 -CompleteDay 7 - None (N=133, 125)Day 7 - A littleDay 7 - SomeDay 7 - A lotDay 7 -Complete
Celecoxib82549521015338431677742
nsNSAIDs533524201214660313158026

Physician Global Assessment of Ankle Injury

Investigator evaluation of overall severity of ankle injury. Scale: 5 point from 1 = Very mild (very mild signs and symptoms of ankle sprain) to 5 =Very severe (very severe signs and symptoms of ankle sprain) (NCT00446797)
Timeframe: Days 3 and 7

,
Interventionparticipants (Number)
Day 3 - very mild (N=134, 131)Day 3 - mildDay 3 - moderateDay 3 - severeDay 3 - very severeDay 7 - very mild (N=132, 125)Day 7 - mildDay 7 - moderateDay 7 - severeDay 7 - very severe
Celecoxib207140218738700
nsNSAIDs127938207047710

Subject Assessment of Normal Function / Activity

"Subject response to question: How does your ankle injury affect your walking and normal activity? Scale from 1 = Normal walking/activity and no pain to 5 = Severely restricted walking due to pain and can't resume normal activities (normal activities defined as all activity that a subject did on a routine basis, including work and recreation)" (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionparticipants (Number)
Day 2 - normal no pain (N =135, 133)Day 2 - normal with painDay 2 - mildly restrictedDay 2 - moderately restrictedDay 2 - severely restrictedDay 3 - normal no pain (N = 135, 131)Day 3 - normal with painDay 3 - mildly restrictedDay 3 - moderately restrictedDay 3 - severely restrictedDay 7 - normal no pain (N = 133, 125)Day 7 - normal with painDay 7 - mildly restrictedDay 7 - moderately restrictedDay 7 - severely restricted
Celecoxib54059191218524914262551141
nsNSAIDs230553971346571144368833

Subject's Global Assessment of Ankle Injury

"Subject response to question: Considering all the ways your ankle injury affects you, how are you doing today? Scale: 5 point from 1 = very good (no symptoms and no limitation of normal activities) to 5 = very poor (very severe symptoms which are intolerable and inability to carry out all normal activities)." (NCT00446797)
Timeframe: Days 2, 3 and 7

,
Interventionparticipants (Number)
Day 2 - Very good (no symptoms) (N=135, 133)Day 2 - Good (mild symptoms)Day 2 - Fair (moderate symptoms)Day 2 - Poor (severe symptoms)Day 2- Very poor (very severe symptoms)Day 3 - Very good (no symptoms) (N=135, 131)Day 3 - Good (mild symptoms)Day 3 - Fair (moderate symptoms)Day 3 - Poor (severe symptoms)Day 3 - Very poor (very severe symptoms)Day 7 - Very good (no symptoms) (N=133, 125)Day 7 - Good (mild symptoms)Day 7 - Fair (moderate symptoms)Day 7 - Poor (severe symptoms)Day 7 - Very poor (very severe symptoms)
Celecoxib14076171868545053611720
nsNSAIDs13180192655637037632140

Need for Rescue Pain Relief

The need for additional analgesics (NCT01827475)
Timeframe: 1 hour

Interventionparticipants (Number)
Ibuprofen11
Acetaminophen10
Ibuprofen-acetaminophen Combination5

Pain Severity

Pain score on 100 mm VAS from 0 (no pain) to 100 (worst pain) (NCT01827475)
Timeframe: 1 hour

Interventionmm (Mean)
Ibuprofen39
Acetaminophen43
Ibuprofen-acetaminophen Combination42

Pain Level Twenty Four Hours After Delivery

The primary outcome is pain measured at 24-hours after delivery. Patients will be asked to report a Visual Analog Scale (VAS) pain score at 24-hours after delivery. This scale ranges from 0 to 10 (0=no pain and 10=worst pain). (NCT01271855)
Timeframe: Twenty-four hours

Interventionunits on a scale (Median)
Glycerin Suppository1
Belladonna and Opioid Suppository2

Patient Satisfaction

Patients' satisfaction with their pain control is recorded at the time of discharge using a five point scale ranging from 1 (Not Satisfied) to 3 (Okay) to 5 (Very Satisfied). (NCT01271855)
Timeframe: Discharge

Interventionunits on a scale (Median)
Glycerin Suppository4
Belladonna and Opioid Suppository5

Change From Baseline in Pain Intensity at Days 14-18

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18

InterventionUnits on a scale (Mean)
Cellegesic (Nitroglycerin 0.4%)-40.4
Placebo-34.9

Percentage of Responders

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18

,
InterventionPercentage of responders (Number)
≥ 50% decrease≥ 10 mm decrease
Cellegisic (Nitroglycerin 0.4%)72.488.6
Placebo64.585.5

Time to an Improvement in Pain Intensity

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21

,
InterventionDays (Mean)
≥ 50% decrease≥ 10 mm decrease
Cellegisic (Nitroglycerin 0.4%)10.76.1
Placebo13.27.2

Area Under the Curve

Subjects were instructed to walk on the treadmill and to tell the research coordinator to stop testing when they reached the point at which they typically would need to stop and sit down, or until 15 minutes had elapsed. At defined intervals (every 30 seconds) subjects were asked what their pain level was according to the NRS. The area under the curve of present pain intensity is the total area combined for the amount of time the subject walked. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale * minutes (Mean)
Opana Then Darvocet Then Placebo76.0
Opana Then Placebo Then Darvocet95.7
Placebo Then Opana Then Darvocet95.0
Placebo Then Darvocet Then Opana86.4
Darvocet Then Opana Then Placebo123.3
Darvocet Then Placebo Then Opana79.6

Final Pain

Subjects were instructed to walk on the treadmill and to tell the research coordinator to stop testing when they reached the point at which they typically would need to stop and sit down, or until 15 minutes had elapsed. At defined intervals subjects were asked what their pain level was according to the NRS. When the subject reached their maximum distance, they were asked their NRS score. This was recorded as final pain intensity. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo4.6
Opana Then Placebo Then Darvocet6.6
Placebo Then Opana Then Darvocet6.2
Placebo Then Darvocet Then Opana6.7
Darvocet Then Opana Then Placebo8.0
Darvocet Then Placebo Then Opana7.1

Modified Brief Pain Inventory (mBPI)- Interference Score

The mBPI is a series of questions that rates the severity and impact of pain on daily function. The questionnaire is made up of 4 pain severity items using the NRS scale, and seven 11-point pain interference scales (0 indicating no interference and 10 indicating complete interference). For the interference score, a total score of 10 indicates pain completely interferes with activities. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo3.7
Opana Then Placebo Then Darvocet4.2
Placebo Then Opana Then Darvocet2.7
Placebo Then Darvocet Then Opana4.3
Darvocet Then Opana Then Placebo6.2
Darvocet Then Placebo Then Opana2.8

Oswestry Disability Index (ODI) Score

The ODI is a set of 10 questions each with five choices (maximum score of 5 points per question) designed to determine how back pain has affected the ability to manage everyday life (pain intensity, personal care, lifting, walking, sitting, standing, sleeping, social life, traveling, and change positions). A score of 0 indicates no disability and total score of 50 would indicate 100% disability. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo37.9
Opana Then Placebo Then Darvocet98.4
Placebo Then Opana Then Darvocet38.0
Placebo Then Darvocet Then Opana44.1
Darvocet Then Opana Then Placebo37.0
Darvocet Then Placebo Then Opana29.7

Patient Global Assessment (PGA)

Subjects were asked to rate their low back pain according to the PGA. PGA is the impact of disease activity. PGA was measured on a 5-point scale, where 1=very good, 2=good, 3=fair, 4=poor, and 5=very poor. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo2.8
Opana Then Placebo Then Darvocet2.8
Placebo Then Opana Then Darvocet3.1
Placebo Then Darvocet Then Opana2.6
Darvocet Then Opana Then Placebo3.3
Darvocet Then Placebo Then Opana2.6

Recovery Time

After the subject completed the treadmill test they were asked to immediately return to the seated position. At this point a timer was started. When the subjects pain level returned to baseline (level of pain subject felt in a seated position before walking) the time was stopped. This was recorded as recovery time. Maximum recovery time is 15 minutes. (NCT00652093)
Timeframe: study visit

Interventionminutes (Mean)
Opana Then Darvocet Then Placebo1.10
Opana Then Placebo Then Darvocet1.50
Placebo Then Opana Then Darvocet2.02
Placebo Then Darvocet Then Opana1.58
Darvocet Then Opana Then Placebo2.15
Darvocet Then Placebo Then Opana1.57

Roland Morris Disability Questionnaire (RMDQ)

The RMDQ consists of 24 yes/no statements about activity limitations due to back pain. These questions center on movement, ambulation, and self-care activities. Positive (yes) answers each contribute 1 point to cumulative score with total scores ranging from 0 (no disability) to 24 (severely disabled). (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo12.8
Opana Then Placebo Then Darvocet15.3
Placebo Then Opana Then Darvocet13.2
Placebo Then Darvocet Then Opana15.2
Darvocet Then Opana Then Placebo13.7
Darvocet Then Placebo Then Opana7.4

Swiss Spinal Stenosis Score- Physical Function

The SSS is a series of questions asking about symptom severity, physical function, and satisfaction. The physical function section is a series of 5 questions (maximum 4 points per question) and asks to rate function for each question based on comfortably, sometimes with pain, always with pain, no functional ability. The total score (max=20) is divided by five. The maximum score for the physical function section (max=4) indicates no ability to function. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo2.5
Opana Then Placebo Then Darvocet2.5
Placebo Then Opana Then Darvocet2.6
Placebo Then Darvocet Then Opana2.6
Darvocet Then Opana Then Placebo2.6
Darvocet Then Placebo Then Opana2.2

Swiss Spinal Stenosis Score- Symptom Severity

The SSS is a series of questions asking about symptom severity, physical function, and satisfaction. The symptom severity section is a set of 7 questions (maximum score is 5 points per question) and asks to rate pain for each question based on no pain, mild, moderate, severe or very severe pain. The total score (maximum=35) is added up and divided by seven. The maximum score for the symptom severity section (score=5) indicates very severe symptom severity. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo2.6
Opana Then Placebo Then Darvocet2.9
Placebo Then Opana Then Darvocet3.2
Placebo Then Darvocet Then Opana3.2
Darvocet Then Opana Then Placebo3.6
Darvocet Then Placebo Then Opana2.9

Time to First Symptoms (Tfirst) of Moderate Pain

Using the Numeric Rating Scale (NRS) (0=no pain, 10=worst pain imaginable)the time to first symptoms (Tfirst) with a NRS score greater than or equal to 4 (moderate pain level), with treadmill ambulation was measured. Patients were excluded from the trial if there pain at rest was greater than or equal to 4/10. (NCT00652093)
Timeframe: study visit

Interventionminutes (Mean)
Opana Then Darvocet Then Placebo1.73
Opana Then Placebo Then Darvocet3.02
Placebo Then Opana Then Darvocet3.93
Placebo Then Darvocet Then Opana2.65
Darvocet Then Opana Then Placebo0.83
Darvocet Then Placebo Then Opana5.43

Total Distance

Subjects were instructed to walk on the treadmill and to tell the research coordinator to stop testing when they reached the point at which they typically would need to stop and sit down, or until 15 minutes had elapsed. When the subject reached their maximum distance, the treadmill testing was stopped. This was recorded as total distance based on number of minutes and seconds walked. Minutes was converted to meters based on calculation of defined speed of the treadmill. (NCT00652093)
Timeframe: study visit

Interventionmeters (Mean)
Opana Then Darvocet Then Placebo266.6
Opana Then Placebo Then Darvocet249.5
Placebo Then Opana Then Darvocet177.9
Placebo Then Darvocet Then Opana290.1
Darvocet Then Opana Then Placebo160.8
Darvocet Then Placebo Then Opana294.8

Visual Analog Scale (VAS)

The VAS asked subjects to place a mark indicative of their low back pain during the past day on a 100mm line, with 0mm representing no pain and 100mm representing extreme pain. (NCT00652093)
Timeframe: study visit

Interventionunits on a scale (Mean)
Opana Then Darvocet Then Placebo51.3
Opana Then Placebo Then Darvocet57.9
Placebo Then Opana Then Darvocet56.2
Placebo Then Darvocet Then Opana46.7
Darvocet Then Opana Then Placebo63.3
Darvocet Then Placebo Then Opana55.1

Paracetamol Intake

Paracetamol intake (500 mg), number of tablets per month. (NCT01342458)
Timeframe: 6 month

Interventiontablets per month (Median)
Intervention Group0
Control Group10

First Peak of the Knee Adduction Moment (KAM) During Gait.

The first peak of the external knee moment was calculated by mean inverse dynamics approach. To this procedure, we used the kinematics data of the lower limbs assessed with six infrared cameras and the ground reaction force evaluated by mean a force platform. This is a continuous measure. (NCT01342458)
Timeframe: 6 month

,
Intervention% body weight x height in centimeters (Mean)
KAM (Baseline)KAM (6th month)
Control Group2.212.28
Intervention Group2.442.37

Global Score of the Lequesne´s Questionaire Algo-functional.

This questionaire consists of three sections (eleven questions): about pain or discomfort, the maximum distance that the patient can walk, and activities of daily living. Scores range from zero to twenty-four, meaning cases without involvement and with extremely severe impairment, respectively. (NCT01342458)
Timeframe: 6 month

,
Interventionscore (Mean)
Lequesne (Baseline)Lequesne (3rd month)Lequesne (6th month)
Control Group11.58.99.7
Intervention Group9.76.35.5

Six-minute Walk Test

The six-minute walk test assesses distance in meters walked over 6 minutes. (NCT01342458)
Timeframe: 6 month

,
Interventionmeter (Mean)
Six-minute walk test (Baseline)Six-minute walk test (3rd month)Six-minute walk test (6th month)
Control Group430.6431.6428.3
Intervention Group433.5453.5439.3

Western Ontario and McMaster Universities (WOMAC) Pain Subscale

The WOMAC (Western Ontario and McMaster Universities) pain subscale consists of five questions (Likert Scale) relating to the patient's pain in everyday situations. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items of pain subscale ranges from 0 to 20. Higher scores indicate worse pain. (NCT01342458)
Timeframe: 6 month

,
Interventionscore (Mean)
WOMAC pain (Baseline)WOMAC pain (3rd month)WOMAC pain (6th month)
Control Group10.06.67.2
Intervention Group9.24.53.1

WOMAC Physical Function Subscale

The physical function subscale included in the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) index consists of seventeen questions (Likert Scale) relating to the patient's physical activities, or skills to move out and take care of themselves. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items of physical function subscale ranges from 0 to 68. Higher scores on the physical function WOMAC subscale indicate worse functional limitations. (NCT01342458)
Timeframe: 6 month

,
Interventionscore (Mean)
WOMAC Physical function subscale (Baseline)WOMAC Physical function subscale (3rd month)WOMAC Physical function subscale (6 month)
Control Group29.620.923.9
Intervention Group27.613.210.2

WOMAC Stiffness Subscale

The stiffness subscale included in the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) index consists of two questions (Likert Scale) relating articular function of the patient. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items of the stiffness subscale ranges from 0 to 8. Higher scores on the stiffness WOMAC subscale indicate worse articular function. (NCT01342458)
Timeframe: 6 month

,
Interventionscore (Mean)
WOMAC Stiffness subscale (Baseline)WOMAC Stiffness subscale (3rd month)WOMAC Stiffness subscale (6th month)
Control Group2.42.92.0
Intervention Group1.80.80.7

WOMAC Total Score

The WOMAC total score is the sum of all subscale (pain, function and stiffness) (Likert Scale) relating to the patient's physical activities, or skills to move out and take care of themselves. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items ranges from 0 to 96. Higher scores on the WOMAC total score indicate worse condition. (NCT01342458)
Timeframe: 6 month

,
Interventionscore (Mean)
WOMAC total score (Baseline)WOMAC total score (3rd month)WOMAC total score (6th month)
Control Group42.030.433.8
Intervention Group37.717.614.3

Change From Baseline to the Average of Weeks 2, 6, and 12 After Trial Entry in Osteoarthritis Function Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Function Subscale Score.

"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Weeks 2, 6, and 12 minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-23.78
Meloxicam 10 mg Once Daily-21.70
Placebo-13.26

Change From Baseline to the Average of Weeks 2, 6, and 12 After Trial Entry in Osteoarthritis Pain Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score.

"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference was calculated as the WOMAC pain subscale score assessed at Weeks 2, 6, and 12 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-30.51
Meloxicam 10 mg Once Daily-27.89
Placebo-20.07

Change From Baseline to the Average of Weeks 2, 6, and 12 After Trial Entry in Osteoarthritis Pain, Stiffness, and Function Measured Using the Total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score.

"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total (composite) WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Weeks 2, 6, and 12 minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-25.15
Meloxicam 10 mg Once Daily-22.83
Placebo-14.67

Change From Baseline to the Average of Weeks 2, 6, and 12 After Trial Entry in Osteoarthritis Stiffness Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale Score.

"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Weeks 2, 6, and 12 minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-24.76
Meloxicam 10 mg Once Daily-21.33
Placebo-13.09

Change From Baseline to Week 12 After Trial Entry in Osteoarthritis Function Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Function Subscale Score.

"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Week 12/early termination minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-28.21
Meloxicam 10 mg Once Daily-28.40
Placebo-17.95

Change From Baseline to Week 12 After Trial Entry in Osteoarthritis Pain Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score.

"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference is calculated as the WOMAC pain subscale score assessed at Week 12 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-36.52
Meloxicam 10 mg Once Daily-34.41
Placebo-25.68

Change From Baseline to Week 12 After Trial Entry in Osteoarthritis Pain, Stiffness, and Function Measured Using the Total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score.

"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Week 12/early termination minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-29.85
Meloxicam 10 mg Once Daily-29.71
Placebo-19.72

Change From Baseline to Week 12 After Trial Entry in Osteoarthritis Stiffness Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale Score.

"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Week 12/early termination minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-29.68
Meloxicam 10 mg Once Daily-28.10
Placebo-18.74

Change From Baseline to Week 2 After Trial Entry in Osteoarthritis Function Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Function Subscale Score.

"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Week 2 minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-20.45
Meloxicam 10 mg Once Daily-14.41
Placebo-10.00

Change From Baseline to Week 2 After Trial Entry in Osteoarthritis Pain Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score.

"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference was calculated as the WOMAC pain subscale score assessed at Week 2 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-26.12
Meloxicam 10 mg Once Daily-20.42
Placebo-16.51

Change From Baseline to Week 2 After Trial Entry in Osteoarthritis Pain, Stiffness, and Function Measured Using the Total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score.

"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Week 2 minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-21.62
Meloxicam 10 mg Once Daily-15.67
Placebo-11.28

Change From Baseline to Week 2 After Trial Entry in Osteoarthritis Stiffness Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale Score.

"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Week 2 minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-19.84
Meloxicam 10 mg Once Daily-14.88
Placebo-8.86

Change From Baseline to Week 6 After Trial Entry in Osteoarthritis Function Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Function Subscale Score.

"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Week 6 minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-24.41
Meloxicam 10 mg Once Daily-24.38
Placebo-14.73

Change From Baseline to Week 6 After Trial Entry in Osteoarthritis Pain Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score.

"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference was calculated as the WOMAC pain subscale score assessed at Week 6 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-31.31
Meloxicam 10 mg Once Daily-30.82
Placebo-20.98

Change From Baseline to Week 6 After Trial Entry in Osteoarthritis Pain, Stiffness, and Function Measured Using the Total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score.

"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Week 6 minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-25.86
Meloxicam 10 mg Once Daily-25.45
Placebo-16.03

Change From Baseline to Week 6 After Trial Entry in Osteoarthritis Stiffness Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale Score.

"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Week 6 minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6

Interventionmm (Least Squares Mean)
Meloxicam 5 mg Once Daily-26.52
Meloxicam 10 mg Once Daily-23.39
Placebo-14.30

Asthma Control Days

proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionproportion of days (Mean)
Acetaminophen.86
Ibuprofen.87

Asthma Rescue Medication Use

average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventioninhalations per week (Mean)
Acetaminophen2.8
Ibuprofen3

Exacerbation Frequency

the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionasthma exacerbations per 46 weeks (Mean)
Acetaminophen0.81
Ibuprofen.87

Health Care Utilization

frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionunscheduled health visits per 46 weeks (Mean)
Acetaminophen.75
Ibuprofen.76

Efficacy of Two Different Liquid Pain Medications: Tramadol vs. Codeine/Acetaminophen During the Post-tonsillectomy Recovery Period.

Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.

Interventiondays (Median)
Capital® With Codeine Suspension1.5
Tramadol Suspension1

Number of Participants Reporting Side Effects During the Post-tonsillectomy Recovery Period.

Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.

,
Interventionparticipants (Number)
NauseaVomitingFeverItchingRashSweatingDizzinessHeadacheConstipationOversedationTonsil bleed
Capital® With Codeine Suspension202111519151221143
Tramadol Suspension201810121717172180

Number of Patients With Pain Associated With Injection of Propofol.

"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.

Interventionparticipants reporting pain (Number)
Lidocaine11
Magnesium25
Lidocaine/Magnesium15
Control18

Percentage of Participants Reporting Pain With Injection of Propofol

Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.

Interventionpercentage of patients reporting pain (Number)
Lidocaine29
Magnesium57
Lidocaine/Magnesium41
Control46

Participants With Edema

Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Participants With Erythema

Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Lactate

A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.

Interventionmmol/L (Mean)
Lactate before pushupsLactate after pushups
Compound Exercise of Push-ups1.517.69

Level of Pain

Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )

,,
Interventionunits on a scale (Mean)
Visit 1Visit 2Visit 3
Compound Exercise of Push-ups.14.19.13
Ibuprofen.39.56.28
Placebo.19.22.06

Serologic Response - A/California/7/2009

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups214.80345.09
Ibuprofen171.00239.25
Placebo216.75343.03

Serologic Response - A/Hong Kong / 4801/2014

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups149.22232.58
Ibuprofen177.78243.13
Placebo221.09296.66

Serologic Response - B/Brisbane/60/2008

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups26.0041.02
Ibuprofen17.4125.47
Placebo26.0934.09

Serologic Response - B/Phuket/3073/2013

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups32.8949.07
Ibuprofen40.1647.34
Placebo36.6944.78

Change From Baseline in Time Weighted Average (TWA) Pain Intensity (PI) on a Numeric Rating Scale (NRS) Due to High-paced Walks on Day 1

Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes,rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following the first treatment on Day 1, PI was similarly measured over a 20 minute high-paced treadmill walk at 5 hrs post-dose. A high-paced walk is the highest pace that can be walked safely for at least 5 minutes that is at a 10-30% higher rate than a self-paced walk. The difference between the TWA (0-20 minutes) PI determined at baseline, and the TWA (0-20 minutes) PI of the high-paced walk on Day 1 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 1

Interventionunits on a scale (Least Squares Mean)
Placebo0.150
Naproxen-0.508
Ultracet-1.00

Change From Baseline in Time Weighted Average (TWA) Pain Intensity (PI) on a Numeric Rating Scale (NRS) Due to High-paced Walks on Day 3

Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes, rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following a single treatment on Day 3, PI was similarly measured over a 20 minute high-paced treadmill walk, at 5 hrs post-dose. A high-paced walk is the highest pace that can be walked safely for at least 5 minutes that is at a 10-30% higher rate than a self-paced walk. The difference between the TWA (0-20 minutes) PI determined at baseline, and the TWA (0-20 minutes) PI of the high-paced walk on Day 3 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 3

Interventionunits on a scale (Least Squares Mean)
Placebo-0.234
Naproxen-1.11
Ultracet-1.30

Change From Baseline in Time Weighted Average (TWA) Pain Intensity (PI) on a Numeric Rating Scale (NRS) Due to Self-paced Walks on Day 1

Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes, rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following the first treatment on Day 1, PI was similarly measured over 20 minute self-paced walks at 2, 4, and 6 hrs post-dose . The difference between the TWA (0-20 minutes) PI determined at baseline, and the average of the three TWA (0-20 minutes)PI from the self-paced walks on Day 1 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 1

Interventionunits on a scale (Least Squares Mean)
Placebo-0.438
Naproxen-0.956
Ultracet-1.47

Change From Baseline in Time Weighted Average (TWA) Pain Intensity (PI) on a Numeric Rating Scale (NRS) Due to Self-paced Walks on Day 3

Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes, rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following a single treatment on Day 3, PI was similarly measured over 20 minute self paced walks at 4 and 6 hrs post-dose. The difference between the TWA (0-20 minutes) PI determined at baseline, and the average of the two TWA (0-20 minutes) PI from the self-paced walks on Day 3 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 3

Interventionunits on a scale (Least Squares Mean)
Placebo-0.927
Naproxen-1.54
Ultracet-1.73

Change in Average Pain Intensities Measured From the Pre-Treatment Walk (Baseline) at 3 Post-Treatment Walks

"Pain intensities(PIs) were measured at pre-dose and 3 post-dose walks (15 Minutes Each Separated by a 45-Minute Rest Interval) on an 11 point scale(0=no pain; 10=worst pain) and averaged for each walk.~Change from baseline was average of post-dose PIs minus average of pre-dose PI." (NCT00565084)
Timeframe: All pain intensities measured from the pre-treatment walk and 3 post-treatment walks (within 3 and half hours post dose, 15 minutes each walk separated by a 45-minute rest interval)

InterventionUnits on a Scale (Least Squares Mean)
Ibuprofen0.24
Placebo 10.18
Placebo 20.18

Clinically Significant Hypotension

Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration

InterventionParticipants (Count of Participants)
Control Group0
Acetaminophen Group0

Blood Pressure

systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention

,
InterventionmmHg (Mean)
SBP: Pre-Intervention (2 hours)SBP: Post-Intervention (4 hours)DBP: Pre-Intervention (2 hours)DBP: Post-Intervention (4 hours)MAP: Pre-Intervention (2 hours)MAP: Post-Intervention (4 hours)
Acetaminophen Group122.6119.566.265.484.182.4
Control Group141.6141.557.451.080.875.5

Equivalent-dose of Vasoactive Medication Post Intervention

"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention

,
Interventionmcg (Number)
Pre-Intervention (2 hours) TOTAL NorepinephrinePre-Intervention (2 hours) TOTAL MilrinonePost-Intervention (4 hours) TOTAL NorepinephrinePost-Intervention (4 hours) TOTAL Milrinone
Acetaminophen GroupNA6000.0NA7000.0
Control Group167.0NA576.0NA

Equivalent-volume Fluid Administered Post Intervention

Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention

,
InterventionmL (Mean)
Pre-Intervention (2 hours) Total fluid INTAKEPre-Intervention (2 hours) Total fluid OUTPUTPost-Intervention (4 hours) Total Fluid INTAKEPost-Intervention (4 hours) Total Fluid OUTPUT
Acetaminophen Group298370612852
Control Group23580734245

Fever Burden

"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention

,
Intervention°C*hours (Mean)
Pre-Intervention FB (2 hours)Post-Intervention FB (6 hours)
Acetaminophen Group2.165.65
Control Group0.970.74

2-hour Change Over Time Core Temperature

change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours

Interventiondegrees Celsius (Mean)
Normal Saline Placebo-0.01
Acetaminophen-0.8

2-hour Change Over Time Heart Rate

2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours

InterventionBPM (Mean)
Normal Saline Placebo2
Acetaminophen-6

2-hour Change Over Time Systolic Blood Pressure

2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours

Interventionmm Hg (Mean)
Normal Saline Placebo-0.1
Acetaminophen-24

Core Body Temperature

time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventiondegrees Celsius (Mean)
Normal Saline Placebo38.4
Acetaminophen37.9

Heart Rate

time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventionbeats per minute (Mean)
Normal Saline Placebo92
Acetaminophen87

Respiratory Rate

time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventionbreaths per minute (Mean)
Normal Saline Placebo22
Acetaminophen21

Systolic Blood Pressure

time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventionmm Hg (Mean)
Normal Saline Placebo143
Acetaminophen127

System Usability Questionnaire

"Ten likert-type questions assessing user-friendliness of technology. Each question has five answer options that range from Strongly Agree to Strongly Disagree. Scores range from 0-100. A score of 68 or above is considered above average. All scores averaged." (NCT03291613)
Timeframe: After 1-hour usability session

Interventionunits on a scale (Mean)
Pinpoint App86.67

Pain Intensity (PI)

Magnitude of pain expressed in millimeters (mm) referred by participants. PI was evaluated through visual analogue scale at moment of performing pressure algometry test in the sensitive point of upper trapezius muscle. PI was assessed with an analogous visual scale where the participant will mark the pain generated by the algometry on a scale of 1 to 100 millimeters. PI was valued in four occasions: PI1 pre (baseline), PI1 post, PI 2 (at day 3) and PI 3 (at day 7). (NCT03636386)
Timeframe: PIpre1 (baseline), PIpost1 (post baseline), PI2 (Day 3), PI3 (Day 7), assessed an average of 3 minutes at each session

,
Interventionmm (Mean)
PIpre1PIpost1PI2PI3PIdiff1-1PIdiff2-1PIdiff3-1
Control Group (Ultrasound Therapy)31.424.823.820.0-6.6-7.6-11.5
Percutaneous Microelectrolysis Group (MEP)32.124.621.618.1-7.5-10.5-14.0

Pain Pressure Threshold (PPT)

Pain Intensity expressed in kilograms per square centimeter(kg/cm2) reported by participants when performing algometry test at sensitive point of upper trapezius muscle. PPT was valued in four occasions: PPT1 pre (baseline), PPT1 post, PPT 2 (at day 3) and PPT 3 (at day 7). PPT will be evaluated through the BASELINE® pressure algometer. (NCT03636386)
Timeframe: PPTpre1 (baseline), PPTpost1 (post baseline), PPT2 (Day 3), PPT3 (Day 7), assessed an average of 30 minutes at each session

,
InterventionKg/cm2 (Mean)
PPTpre1PPTpost1PPT2PPT3PPTdiff1-1PPTdiff2-1PPTdiff3-1
Control Group (Ultrasound Therapy)1.41.61.61.70.20.20.3
Percutaneous Microelectrolysis Group (MEP)1.41.61.71.90.20.40.5

Length of Hospitalization

Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days

InterventionDays (Median)
Inhaled Nitric Oxide4.06
Placebo3.11

Number of Participants Discharged to Home Within the First 24 Hours

(NCT00094887)
Timeframe: within 24 hours

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide5
Placebo7

Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion

Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide8
Placebo7

Time to Vaso-occlusive Pain Crisis (VOC) Resolution

"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days

InterventionHours (Median)
Inhaled Nitric Oxide61.83
Placebo55.16

Number of Participants Readmitted to Hospital Within 30 Days After Discharge

The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up

,
InterventionParticipants (Count of Participants)
during first 24 hoursduring 30-day follow-up
Inhaled Nitric Oxide09
Placebo017

Total Dose of Opioids Received

The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days

,
Interventionmg (Median)
within 8 hourswithin 40 days
Inhaled Nitric Oxide16.25153.75
Placebo17.25211.37

Reviews

235 reviews available for acetaminophen and Ache

ArticleYear
The efficacy and safety of acetaminophen use following liver resection: a systematic review.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2022, Volume: 24, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Hepatectomy; Humans; Liver; Morphine; Observational Studie

2022
Perioperative Buprenorphine Management: A Multidisciplinary Approach.
    The Medical clinics of North America, 2022, Volume: 106, Issue:1

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2022
Deprescribing paracetamol in pain conditions: A scoping review.
    Research in social & administrative pharmacy : RSAP, 2022, Volume: 18, Issue:8

    Topics: Acetaminophen; Adult; Deprescriptions; Humans; Pain; Prospective Studies

2022
Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity.
    Medicina (Kaunas, Lithuania), 2021, Dec-28, Volume: 58, Issue:1

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cisplatin; Humans; Pain

2021
Sterile water injections for management of renal colic pain: a systematic review.
    Scandinavian journal of urology, 2022, Volume: 56, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Morphine Derivatives; Pa

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Analgesia for retinopathy of prematurity screening: A systematic review.
    Pain practice : the official journal of World Institute of Pain, 2022, Volume: 22, Issue:7

    Topics: Acetaminophen; Analgesia; Fentanyl; Humans; Infant, Newborn; Nitrous Oxide; Pain; Pain Measurement;

2022
Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension.
    Hypertension (Dallas, Tex. : 1979), 2022, Volume: 79, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ca

2022
Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis.
    Medicine, 2022, Sep-09, Volume: 101, Issue:36

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pain; Quality of Lif

2022
Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials.
    British journal of sports medicine, 2023, Volume: 57, Issue:15

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Exercise Therapy; Humans;

2023
Pharmacokinetic and pharmacodynamic herb-drug interactions of common over-the-counter pain medications.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:7

    Topics: Acetaminophen; Aspirin; Herb-Drug Interactions; Humans; Ibuprofen; Naproxen; Pain

2023
Common Selfcare Indications of Pain Medications in Children.
    Paediatric drugs, 2023, Volume: 25, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; COVID-19; Fever; Humans; Ibuprofen; Pain

2023
In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis.
    Paediatric and perinatal epidemiology, 2023, Volume: 37, Issue:5

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Child; Europe; Humans; Pain; Prospecti

2023
Evidence-based labor management: postpartum care after vaginal delivery (part 6).
    American journal of obstetrics & gynecology MFM, 2023, Volume: 5, Issue:7

    Topics: Acetaminophen; Anticoagulants; Delivery, Obstetric; Female; Humans; Infant; Pain; Postnatal Care; Pr

2023
Identifying Residents Who May Benefit from an Analgesic Review: Applying Analgesic Indicators in Residential Aged Care Services.
    Drugs & aging, 2023, Volume: 40, Issue:5

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Australia; Cross-Sectional Studies; Female; Hum

2023
Is coadministration of preemptive medications an effective strategy for reducing inflammatory clinical events and the need for rescue medication after mandibular third molar surgery? A systematic review of randomized clinical trials.
    Inflammopharmacology, 2023, Volume: 31, Issue:4

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Molar, Third; Pain; Rand

2023
A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis.
    Pediatric rheumatology online journal, 2023, Jun-16, Volume: 21, Issue:1

    Topics: Acetaminophen; Arthritis, Juvenile; Child; Humans; Pain; Pain Management; Quality of Life

2023
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.
    The Cochrane database of systematic reviews, 2023, 08-11, Volume: 8

    Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, N

2023
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2023, 08-18, Volume: 8

    Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans;

2023
Breastfeeding or breast milk for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 08-29, Volume: 8

    Topics: Acetaminophen; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Milk, Human; Pain; Pain, Pro

2023
Network meta-analysis of randomized controlled trials comparing the effectiveness of different treatments in reducing amniocentesis-associated pain and anxiety.
    BMC pregnancy and childbirth, 2023, Nov-21, Volume: 23, Issue:1

    Topics: Acetaminophen; Amniocentesis; Anxiety; Female; Humans; Network Meta-Analysis; Pain; Pregnancy; Rando

2023
Antiinflammatory Drugs.
    The Veterinary clinics of North America. Small animal practice, 2019, Volume: 49, Issue:6

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Pain; Pain Management

2019
Pain Management Protocols During Uterine Fibroid Embolisation: A Systematic Review of the Evidence.
    Cardiovascular and interventional radiology, 2019, Volume: 42, Issue:12

    Topics: Acetaminophen; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age

2019
Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.
    Clinics in perinatology, 2019, Volume: 46, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; C

2019
Do analgesics used for the pain experienced after orthodontic procedures affect tooth movement rate? A systematic review based on animal studies.
    Orthodontics & craniofacial research, 2020, Volume: 23, Issue:2

    Topics: Acetaminophen; Analgesics; Animals; Humans; Pain; Tooth Movement Techniques

2020
Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review.
    Danish medical journal, 2019, Volume: 66, Issue:12

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat

2019
Nonprescription drugs recommended in guidelines for common pain conditions.
    Pain management, 2020, Volume: 10, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir

2020
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
    The Cochrane database of systematic reviews, 2020, 01-27, Volume: 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Infant, Newborn; Pain; Pain Management; Randomized

2020
Pharmacotherapy for knee osteoarthritis: current and emerging therapies.
    Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agen

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2020, 08-12, Volume: 8

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl

2020
Systematic review and meta-analysis of oral paracetamol versus combination oral analgesics for acute musculoskeletal injuries.
    Emergency medicine Australasia : EMA, 2021, Volume: 33, Issue:1

    Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammator

2021
The efficacy of analgesics in controlling orthodontic pain: a systematic review and meta-analysis.
    BMC oral health, 2020, 09-18, Volume: 20, Issue:1

    Topics: Acetaminophen; Analgesics; Humans; Ibuprofen; Pain; Pain Management

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Relief of pain due to uterine cramping/involution after birth.
    The Cochrane database of systematic reviews, 2020, 10-20, Volume: 10

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
    JAMA network open, 2020, 10-01, Volume: 3, Issue:10

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Fever; Humans; Ibu

2020
Opioid Use and Misuse in Pregnancy.
    Clinics in perinatology, 2020, Volume: 47, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory A

2020
The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews.
    The Medical journal of Australia, 2021, Volume: 214, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Craniotomy; Data Management; Humans;

2021
Ibuprofen vs. Acetaminophen for Fever or Pain in Children Younger Than Two Years.
    American family physician, 2021, 05-01, Volume: 103, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Ibuprofen; Infant; Pain; Patient Selection;

2021
Pharmacological Means of Pain Control during Separator Placement: A Systematic Review.
    The journal of contemporary dental practice, 2021, Mar-01, Volume: 22, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Ibuprofen; Pain; Pain Management; Pain Measurement;

2021
Paracetamol: unconventional uses of a well-known drug.
    The International journal of pharmacy practice, 2021, Dec-04, Volume: 29, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Illicit Drugs; Pain

2021
[Revision of the Dutch College of General Practitioners practice guideline 'Children with fever'].
    Nederlands tijdschrift voor geneeskunde, 2017, Volume: 161

    Topics: Acetaminophen; Child; Family Practice; Fever; General Practitioners; Humans; Ibuprofen; Netherlands;

2017
Improving the treatment of infant pain.
    Current opinion in supportive and palliative care, 2017, Volume: 11, Issue:2

    Topics: Acetaminophen; Administration, Cutaneous; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroida

2017
What is the best analgesic option for patients presenting with renal colic to the emergency department? Protocol for a systematic review and meta-analysis.
    BMJ open, 2017, 05-04, Volume: 7, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Checklist; C

2017
Perinatal and neonatal use of paracetamol for pain relief.
    Seminars in fetal & neonatal medicine, 2017, Volume: 22, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Infant, Newborn; Pain; Pain Management; Pre

2017
Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree.
    Current pharmaceutical design, 2017, Volume: 23, Issue:38

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Decision Trees; Dose-Response Relationship, Drug; Humans; I

2017
NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis.
    BMJ evidence-based medicine, 2018, Volume: 23, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Me

2018
    MMW Fortschritte der Medizin, 2018, Volume: 160, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Meta-Analysis; Osteoarthriti

2018
Commonly used nonopioid analgesics in adults.
    Nursing, 2018, Volume: 48, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Non

2018
What dose of paracetamol for older people?
    Drug and therapeutics bulletin, 2018, Volume: 56, Issue:6

    Topics: Acetaminophen; Age Factors; Aged, 80 and over; Analgesics; Chemical and Drug Induced Liver Injury; D

2018
Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations.
    Scandinavian journal of medicine & science in sports, 2018, Volume: 28, Issue:11

    Topics: Acetaminophen; Adaptation, Physiological; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Ag

2018
Can I take my normal painkillers doctor? Therapeutic management of pain following dermatological procedures.
    The Australasian journal of dermatology, 2019, Volume: 60, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2019
[Pharmacological Basis of Pain Treatment].
    Deutsche medizinische Wochenschrift (1946), 2018, Volume: 143, Issue:19

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Dipy

2018
Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review.
    Current rheumatology reports, 2018, 11-21, Volume: 20, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2018
Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies.
    European journal of orthodontics, 2019, Sep-21, Volume: 41, Issue:5

    Topics: Acetaminophen; Analgesics; Animals; Humans; Ibuprofen; Pain; Tooth Movement Techniques

2019
Pain Management in Trauma in the Age of the Opioid Crisis.
    Anesthesiology clinics, 2019, Volume: 37, Issue:1

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Gabapentin; Humans

2019
Pain assessment and pain treatment for community-dwelling people with dementia: A systematic review and narrative synthesis.
    International journal of geriatric psychiatry, 2019, Volume: 34, Issue:6

    Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Dementia; Humans

2019
Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review.
    European journal of orthodontics, 2019, Sep-21, Volume: 41, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Child; Dental Care; Female; Humans; Ibuprofen; Middle Aged; Orthod

2019
Intravenous Acetaminophen-Induced Hypotension: A Review of the Current Literature.
    The Annals of pharmacotherapy, 2019, Volume: 53, Issue:10

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Blood Pressure; Critical Illne

2019
A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease.
    Journal of pain & palliative care pharmacotherapy, 2018, Volume: 32, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Liver Diseases; Pain

2018
Paracetamol versus other analgesia in adult patients with minor musculoskeletal injuries: a systematic review.
    Emergency medicine journal : EMJ, 2019, Volume: 36, Issue:8

    Topics: Acetaminophen; Adult; Analgesia; Analgesics; Humans; Musculoskeletal Diseases; Pain; Pain Management

2019
Medication Use and Pain Management in Pregnancy: A Critical Review.
    Pain practice : the official journal of World Institute of Pain, 2019, Volume: 19, Issue:8

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug

2019
Benzhydrocodone/acetaminophen (Apadaz) for pain.
    The Medical letter on drugs and therapeutics, 2019, Jul-15, Volume: 61, Issue:1576

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Humans; Hydrocodone;

2019
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain

2013
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain

2013
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain

2013
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain

2013
Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin.
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:16

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2013
Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.
    Dermatology online journal, 2013, Nov-15, Volume: 19, Issue:11

    Topics: Acetaminophen; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclohexaneca

2013
Neonatal pain.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:1

    Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag

2014
Neonatal pain.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:1

    Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag

2014
Neonatal pain.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:1

    Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag

2014
Neonatal pain.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:1

    Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag

2014
Paracetamol: a focus for the general pediatrician.
    European journal of pediatrics, 2014, Volume: 173, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Fever; Humans; Pain; Risk Factors

2014
[Risks and benefits of paracetamol in children with fever].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Pain; Risk Assessme

2014
An overview of pain management: the clinical efficacy and value of treatment.
    The American journal of managed care, 2013, Volume: 19, Issue:14 Suppl

    Topics: Acetaminophen; Acute Disease; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic P

2013
Changes coming in pain management?
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2014, Volume: 67, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Approval; Humans; Pain; Pain Management; Pain Measurem

2014
Acute perioperative pain in neonates: An evidence-based review of neurophysiology and management.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2014, Volume: 52, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesia; Analgesics, Opioid; Anesthesia, Epidural; Evidence-Based Me

2014
[A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl].
    No to hattatsu = Brain and development, 2014, Volume: 46, Issue:4

    Topics: Acetaminophen; Amines; Child; Cyclohexanecarboxylic Acids; Drug Combinations; Fentanyl; Gabapentin;

2014
Codeine, alone and with paracetamol (acetaminophen), for cancer pain.
    The Cochrane database of systematic reviews, 2014, Sep-19, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combinati

2014
[Paracetamol-codeine, an always actual choice for the treatment of pain].
    Minerva medica, 2014, Volume: 105, Issue:6

    Topics: Acetaminophen; Activation, Metabolic; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal;

2014
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2015
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2015
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2015
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2015
A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Codeine; Drug Comb

2015
Intravenous acetaminophen use in pediatrics.
    Pediatric emergency care, 2015, Volume: 31, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bicycling; Body Weight; Chemic

2015
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
    The Cochrane database of systematic reviews, 2015, Jun-25, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Infant, Newborn; Pain; Randomized Controlled Trials

2015
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
    The Cochrane database of systematic reviews, 2015, Jul-01, Issue:7

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Analgesics, Opioid; Anti-Inflammator

2015
WITHDRAWN: NSAIDS or paracetamol, alone or combined with opioids, for cancer pain.
    The Cochrane database of systematic reviews, 2015, Jul-31, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2015
[Analgesia in patients with hepatic impairment].
    Revue medicale suisse, 2015, Jun-24, Volume: 11, Issue:480

    Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; H

2015
Pain management in patients with hidradenitis suppurativa.
    Journal of the American Academy of Dermatology, 2015, Volume: 73, Issue:5 Suppl 1

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics; Anti-Inflammatory A

2015
Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults.
    The Cochrane database of systematic reviews, 2016, Feb-12, Volume: 2

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Androstanols; Anesthetics, Local; Child; Fentanyl; Humans;

2016
A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes.
    Current medical research and opinion, 2016, Volume: 32, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements; Disease Progression; Gl

2016
Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.
    Nature reviews. Endocrinology, 2016, Volume: 12, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Commerce;

2016
Oral NSAIDs versus other oral analgesic agents for acute soft tissue injury.
    International journal of evidence-based healthcare, 2016, Volume: 14, Issue:3

    Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-S

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2016, Aug-08, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2016
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
    The Cochrane database of systematic reviews, 2016, Oct-07, Volume: 10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Delivery, Obstetric; Diagnostic Techniques, Ophthalmologica

2016
Analgesia in the surgical intensive care unit.
    Postgraduate medical journal, 2017, Volume: 93, Issue:1095

    Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C

2017
Paracetamol and morphine for infant and neonatal pain; still a long way to go?
    Expert review of clinical pharmacology, 2017, Volume: 10, Issue:1

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Humans; Infant; I

2017
Clinical update on benefit versus risks of oral paracetamol alone or with codeine: still a good option?
    Current medical research and opinion, 2017, Volume: 33, Issue:2

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory

2017
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2016, 12-15, Volume: 12

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age

2016
Comparing the effectiveness profile of pharmacological interventions used for orthodontic pain relief: an arm-based multilevel network meta-analysis of longitudinal data.
    European journal of orthodontics, 2017, Nov-30, Volume: 39, Issue:6

    Topics: Acetaminophen; Analgesics; Drug Administration Schedule; Etoricoxib; Humans; Ibuprofen; Network Meta

2017
Paracetamol/Tramadol association: the easy solution for mild-moderate pain.
    Minerva medica, 2008, Volume: 99, Issue:4

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Th

2008
Effectiveness of oral vs rectal acetaminophen: a meta-analysis.
    Archives of pediatrics & adolescent medicine, 2008, Volume: 162, Issue:11

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Child; Fever;

2008
[The combination acetominophen/tramadol in hematological daily practice].
    Minerva medica, 2008, Volume: 99, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Biopsy, Fine-Needle; Bone Marrow; Drug Therapy, Combination

2008
Intravenous paracetamol (acetaminophen).
    Drugs, 2009, Volume: 69, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Controlled Clinical Trials as Topic; Fever; H

2009
Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists.
    Acta anaesthesiologica Belgica, 2008, Volume: 59, Issue:4

    Topics: Acetaminophen; Age Factors; Analgesics; Anesthesiology; Biological Availability; Cyclooxygenase Inhi

2008
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
    Current medical research and opinion, 2009, Volume: 25, Issue:9

    Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem

2009
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
    Clinical therapeutics, 2009, Volume: 31 Suppl 2

    Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C

2009
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
    Clinical therapeutics, 2009, Volume: 31 Suppl 2

    Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C

2009
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
    Clinical therapeutics, 2009, Volume: 31 Suppl 2

    Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C

2009
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
    Clinical therapeutics, 2009, Volume: 31 Suppl 2

    Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C

2009
Clinical safety and tolerability of ibuprofen compared with paracetamol in pediatric pain and fever. A systematic review.
    Minerva pediatrica, 2009, Volume: 61, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Ibuprofen; Pain

2009
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review.
    The Annals of pharmacotherapy, 2010, Volume: 44, Issue:3

    Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Female; Fever; Humans; Ibuprofen

2010
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2010, Mar-17, Issue:3

    Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain

2010
Pain management in the cirrhotic patient: the clinical challenge.
    Mayo Clinic proceedings, 2010, Volume: 85, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

2010
[Treatment of acute pain during drug-assisted rehabilitation].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010, Apr-08, Volume: 130, Issue:7

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents

2010
Oxycodone combinations for pain relief.
    Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:6

    Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspi

2010
A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Caffeine; Central Nervous System Stimulants; Datab

2010
Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.
    Clinical drug investigation, 2010, Volume: 30 Suppl 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Drug Synergism; Huma

2010
Tramadol/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe pain.
    Clinical drug investigation, 2010, Volume: 30, Issue:10

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations

2010
Osteoarthritis: a review of treatment options.
    Geriatrics, 2009, Volume: 64, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2009
Methylxanthines and pain.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interact

2011
Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:8

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Analgesics, Non-Narcotic; Emergency Service, Hospita

2011
What do we (not) know about how paracetamol (acetaminophen) works?
    Journal of clinical pharmacy and therapeutics, 2010, Volume: 35, Issue:6

    Topics: Acetaminophen; Acetanilides; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat

2010
[Solutions for the clinical problems of analgesics for cancer pain treatment in Japan].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:1

    Topics: Acetaminophen; Analgesics; Drug Administration Routes; Fentanyl; Humans; Japan; Neoplasms; Oxycodone

2011
Pharmacotherapy for acute pain in children: current practice and recent advances.
    Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:6

    Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents,

2011
[Analgesia for pediatric patients. Standards and special aspects].
    Medizinische Monatsschrift fur Pharmazeuten, 2011, Volume: 34, Issue:1

    Topics: Acetaminophen; Adolescent; Analgesia; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti

2011
Assessment of acute and persistent pain management in patients with haemophilia.
    Haemophilia : the official journal of the World Federation of Hemophilia, 2011, Volume: 17, Issue:4

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents,

2011
Analgosedation in neonates: do we still need additional tools after 30 years of clinical research?
    Archives of disease in childhood. Education and practice edition, 2011, Volume: 96, Issue:3

    Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Analgesia; Analgesics, Opioid; Dexmedetomidine;

2011
Intravenous acetaminophen (Ofirmev).
    The Medical letter on drugs and therapeutics, 2011, Apr-04, Volume: 53, Issue:1361

    Topics: Acetaminophen; Animals; Chemistry, Pharmaceutical; Drug Approval; Humans; Infusions, Intravenous; In

2011
Clinical inquiries. Which treatments provide the most relief for pharyngitis pain?
    The Journal of family practice, 2011, Volume: 60, Issue:5

    Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Evidenc

2011
Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials.
    Drugs in R&D, 2011, Sep-01, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Common Cold; Double-Blind Me

2011
Management of chronic noncancer pain in depressed patients.
    Postgraduate medicine, 2011, Volume: 123, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

2011
Acetaminophen injection: a review of clinical information.
    Journal of pain & palliative care pharmacotherapy, 2011, Volume: 25, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Child, P

2011
The role of paracetamol and nonsteroidal anti-inflammatory drugs in addition to WHO Step III opioids in the control of pain in advanced cancer. A systematic review of the literature.
    Palliative medicine, 2012, Volume: 26, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2012
Acetaminophen injection: a review of clinical information including forms not available in the United States.
    Journal of pain & palliative care pharmacotherapy, 2012, Volume: 26, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Trials as Topic; Humans; Injections, Intravenous;

2012
Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold.
    Best practice & research. Clinical gastroenterology, 2012, Volume: 26, Issue:2

    Topics: Acetaminophen; Aspirin; Common Cold; Dyspepsia; Fever; Gastrointestinal Tract; Humans; Ibuprofen; No

2012
Nonsteroidal antiinflammatory drugs, acetaminophen, and hypertension.
    Current hypertension reports, 2012, Volume: 14, Issue:4

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox

2012
Pharmaceutical therapy for osteoarthritis.
    PM & R : the journal of injury, function, and rehabilitation, 2012, Volume: 4, Issue:5 Suppl

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 I

2012
The effect of paracetamol and tropisetron on pain: experimental studies and a review of published data.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cross-Over Studies; Double-Blind Method; Dr

2013
Paracetamol for the management of pain in inflammatory arthritis: a systematic literature review.
    The Journal of rheumatology. Supplement, 2012, Volume: 90

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis; Clinical Trials as Topic; Evidence-Based Medicin

2012
Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review.
    The Journal of rheumatology. Supplement, 2012, Volume: 90

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agen

2012
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
    The Cochrane database of systematic reviews, 2012, Sep-12, Issue:9

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H

2012
Optimising the management of fever and pain in children.
    International journal of clinical practice. Supplement, 2013, Issue:178

    Topics: Acetaminophen; Analgesics; Child; Comparative Effectiveness Research; Dose-Response Relationship, Dr

2013
Perioperative pain control in pediatric patients undergoing orthopaedic surgery.
    The Journal of the American Academy of Orthopaedic Surgeons, 2012, Volume: 20, Issue:12

    Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory

2012
The long and winding road of non steroidal antinflammatory drugs and paracetamol in cancer pain management: a critical review.
    Critical reviews in oncology/hematology, 2013, Volume: 87, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms;

2013
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Analgesics for the treatment of pain in children.
    The New England journal of medicine, 2002, Oct-03, Volume: 347, Issue:14

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A

2002
Rational use of analgesic combinations.
    Dental clinics of North America, 2002, Volume: 46, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

2002
[Efficacy and safety of acetaminophen-codeine in the treatment of pain].
    Revue medicale de Liege, 2002, Volume: 57, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combination; Hum

2002
Demographics, assessment and management of pain in the elderly.
    Drugs & aging, 2003, Volume: 20, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agen

2003
Interventions for relieving the pain and discomfort of screening mammography.
    The Cochrane database of systematic reviews, 2002, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Mammography; Pain; Premedication; Pressure;

2002
Pain management in children with sickle cell disease.
    Paediatric drugs, 2003, Volume: 5, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool;

2003
Treating osteoarthritis pain.
    The Nurse practitioner, 2003, Volume: 28, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitor

2003
Tramadol/paracetamol.
    Drugs, 2003, Volume: 63, Issue:11

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Biological Availability; Chronic Dis

2003
The new analgesic combination tramadol/acetaminophen.
    European journal of anaesthesiology. Supplement, 2003, Volume: 28

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Humans; Pain; Tramad

2003
A pictorial and video guide to circumcision without pain.
    Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2003, Volume: 3, Issue:2

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Local; Attitude of Heal

2003
Analgesia in patients with ESRD: a review of available evidence.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:2

    Topics: Acetaminophen; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anti-

2003
Nonopioid and adjuvant analgesics in chronic pain management: strategies for effective use.
    The Nursing clinics of North America, 2003, Volume: 38, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal

2003
[Antinociceptive mechanism of action of paracetamol].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena

2003
[Pharmacologic basis for using paracetamol: pharmacokinetic and pharmacodynamic issues].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adolescent; Adult; Age Factors; Analges

2003
[Paracetamol in the treatment of osteoarthritis pain].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg

2003
[Pain management: health economics and quality of life considerations].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cost Control; Cost of Illness; Drug Costs; Humans; Pain; Qu

2003
[Role of paracetamol in the acute pain management].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Clinical Trials as Topic; Humans; Pain

2003
[New perspectives on paracetamol].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Administration, Oral; Advertising; Analgesics, Non-Narcotic; Chemical and Drug Induce

2003
Translating research into practice: acetaminophen in osteoarthritis revisited.
    The Journal of rheumatology, 2004, Volume: 31, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Pain

2004
Pharmacological management of head and neck pain.
    Otolaryngologic clinics of North America, 2003, Volume: 36, Issue:6

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Head; Humans; Neck; Pain

2003
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
    Duodecim; laaketieteellinen aikakauskirja, 2004, Volume: 120, Issue:2

    Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr

2004
Pharmacological techniques for managing acute pain in emergency departments.
    Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2004, Volume: 12, Issue:1

    Topics: Acetaminophen; Acute Disease; Adult; Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Local; A

2004
Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis.
    Archives of pediatrics & adolescent medicine, 2004, Volume: 158, Issue:6

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Ibuprof

2004
Acetaminophen as symptomatic treatment of pain from osteoarthritis.
    Joint bone spine, 2004, Volume: 71, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinica

2004
[Problem forte--is paracetamol-codeine combination rational?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2004, Aug-26, Volume: 124, Issue:16

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Codeine

2004
[Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip].
    Atencion primaria, 2004, Volume: 34, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Costs and Cost Analysis; Cyclooxygenase 2; Cyclooxygenase 2

2004
NSAIDS or paracetamol, alone or combined with opioids, for cancer pain.
    The Cochrane database of systematic reviews, 2005, Jan-25, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2005
Oral analgesics for acute nonspecific pain.
    American family physician, 2005, Mar-01, Volume: 71, Issue:5

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Algorithms; Analgesics, Non-Narcotic; Aspirin; H

2005
Basic pharmacology and advances in emergency medicine.
    Emergency medicine clinics of North America, 2005, Volume: 23, Issue:2

    Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; C

2005
Valdecoxib for the management of chronic and acute pain.
    Expert review of neurotherapeutics, 2005, Volume: 5, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chr

2005
Rheumatic diseases in the elderly: dealing with rheumatic pain in extended care facilities.
    Clinics in geriatric medicine, 2005, Volume: 21, Issue:3

    Topics: Acetaminophen; Aged; Algorithms; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2005
Drugs for pain management in dentistry.
    Australian dental journal, 2005, Volume: 50, Issue:4 Suppl 2

    Topics: Acetaminophen; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Dental Care; Humans

2005
Cancer-related pain and its pharmacologic management in the patient with bone metastasis.
    The journal of supportive oncology, 2006, Volume: 4, Issue:2 Suppl 1

    Topics: Acetaminophen; Analgesics; Bone Neoplasms; Diphosphonates; Humans; Narcotics; Neoplasm Metastasis; P

2006
Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir

2006
Nonnarcotic analgesics and hypertension.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pre

2006
Gastrointestinal Considerations in Patients with Cardiovascular Disease Using Nonopioid Analgesics for Mild-to-Moderate Pain or Cardioprotection.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 Inhibito

2006
Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection.
    The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Cyclo

2006
Pain control: non-steroidal anti-inflammatory agents.
    Seminars in fetal & neonatal medicine, 2006, Volume: 11, Issue:4

    Topics: Absorption; Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug

2006
Update on guidelines for the treatment of chronic musculoskeletal pain.
    Clinical rheumatology, 2006, Volume: 25 Suppl 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2006
Combination analgesia in 2005 - a rational approach: focus on paracetamol-tramadol.
    Clinical rheumatology, 2006, Volume: 25 Suppl 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2006
Pharmacological aspects of successful long-term analgesia.
    Clinical rheumatology, 2006, Volume: 25 Suppl 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2006
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu.
    Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:4

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Com

2006
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
    Journal of the National Medical Association, 2006, Volume: 98, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A

2006
[Management strategies for the treatment of non malignant chronic pain in the elderly].
    Psychologie & neuropsychiatrie du vieillissement, 2006, Volume: 4, Issue:3

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Humans; Musculos

2006
Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolinones.
    Handbook of experimental pharmacology, 2007, Issue:177

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxyg

2007
Spinal cord injury.
    The journal of pain, 2006, Volume: 7, Issue:12

    Topics: Acetaminophen; Adult; Cognitive Behavioral Therapy; Colloids; Female; Humans; Pain; Pain Management;

2006
[Clinical pharmacology of analgesics].
    Der Orthopade, 2007, Volume: 36, Issue:1

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain

2007
[Non-opioid analgesics in cancer pain].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:1

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms; Pain

2007
Tramadol for osteoarthritis: a systematic review and metaanalysis.
    The Journal of rheumatology, 2007, Volume: 34, Issue:3

    Topics: Acetaminophen; Analgesics, Opioid; Drug Therapy, Combination; Humans; Osteoarthritis; Pain; Pain Mea

2007
A 60-year-old woman considering acupuncture for knee pain.
    JAMA, 2007, Apr-18, Volume: 297, Issue:15

    Topics: Acetaminophen; Acupuncture Therapy; Adrenal Cortex Hormones; Analgesics, Opioid; Anti-Inflammatory A

2007
Pharmacologic management of adult cancer pain.
    Oncology (Williston Park, N.Y.), 2007, Volume: 21, Issue:2 Suppl Nu

    Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug

2007
A new solution to pain control.
    Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2007, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Emergency Service, Hospital; Humans; Infusions, Intravenous

2007
Levator ani syndrome - a case study and literature review.
    Australian family physician, 2007, Volume: 36, Issue:6

    Topics: Acetaminophen; Adult; Anal Canal; Analgesics, Non-Narcotic; Anus Diseases; Baths; Diazepam; Family P

2007
Management of pain in childhood.
    Archives of disease in childhood. Education and practice edition, 2007, Volume: 92, Issue:4

    Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local;

2007
Using paracetamol before immunisation--does it work?
    Nursing New Zealand (Wellington, N.Z. : 1995), 2007, Volume: 13, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Evidence-Based Medicine; Fever; Humans; Pain; Practice Guid

2007
Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration.
    Archives of disease in childhood, 2008, Volume: 93, Issue:3

    Topics: Acetaminophen; Adult; Age Factors; Analgesia; Analgesics, Non-Narcotic; Body Temperature; Child; Dos

2008
Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs?
    Canadian family physician Medecin de famille canadien, 2007, Volume: 53, Issue:7

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclooxygenase 2 Inhi

2007
Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics.
    CNS drug reviews, 2007,Fall, Volume: 13, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Humans; Nitrates; Pain

2007
Recent advances in the pharmacological management of pain.
    Drugs, 2007, Volume: 67, Issue:15

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals

2007
Pain medications in the locker room: to dispense or not.
    Current sports medicine reports, 2007, Volume: 6, Issue:6

    Topics: Acetaminophen; Anesthetics; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Doping in Sp

2007
Nonopioid analgesics.
    Anesthesiology clinics, 2007, Volume: 25, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxyg

2007
COX-2 selective inhibitors in the treatment of osteoarthritis.
    Seminars in arthritis and rheumatism, 2008, Volume: 38, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl

2008
Interventions for relieving the pain and discomfort of screening mammography.
    The Cochrane database of systematic reviews, 2008, Jan-23, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Mammography; Pain; Patient Education as Top

2008
Management of chronic musculoskeletal pain in the elderly: opinions on oral medication use.
    Inflammopharmacology, 2008, Volume: 16, Issue:2

    Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipain; Chroni

2008
Analgesic efficacy of dextropropoxyphene and dextropropoxyphene-containing combinations: a review.
    Human toxicology, 1984, Volume: 3 Suppl

    Topics: Acetaminophen; Aminoacridines; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Chlorambucil

1984
Chronic pain of childhood: a pharmacologic approach.
    Pediatric clinics of North America, 1984, Volume: 31, Issue:5

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Anticon

1984
Use of antipyretic analgesics in the pediatric patient.
    The American journal of medicine, 1983, Nov-14, Volume: 75, Issue:5A

    Topics: Acetaminophen; Adolescent; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemic

1983
[Paracetamol: overdose and hepatic lesions].
    La Clinica terapeutica, 1981, Jul-31, Volume: 98, Issue:2

    Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain

1981
Acetaminophen toxicity: report of case and review of the literature.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1995, Volume: 53, Issue:10

    Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Blood Coagulation; Chemical and Drug Ind

1995
Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat.
    Acta anaesthesiologica Scandinavica. Supplementum, 1995, Volume: 103

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Brain;

1995
Acetylsalicylic acid and acetaminophen.
    Dental clinics of North America, 1994, Volume: 38, Issue:4

    Topics: Acetaminophen; Adult; Aspirin; Child; Dental Care; Humans; Pain

1994
[Paracetamol and other antipyretic analgesics: optimal doses in pediatrics].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1994, Volume: 1, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Dose-Response Relationship, Drug; Dru

1994
Pain management for the geriatric patient.
    Clinics in podiatric medicine and surgery, 1994, Volume: 11, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Narcotics; Pain; P

1994
Should osteoarthritis be treated with nonsteroidal anti-inflammatory drugs?
    Rheumatic diseases clinics of North America, 1993, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Drug Costs

1993
[Effectiveness of fixed analgesic combinations exemplified by thomapyrin].
    Wiener klinische Wochenschrift, 1996, Volume: 108, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Germany; Humans; Pain

1996
Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review.
    BMJ (Clinical research ed.), 1996, Aug-10, Volume: 313, Issue:7053

    Topics: Acetaminophen; Analgesia; Analgesics; Clinical Trials as Topic; Codeine; Dose-Response Relationship,

1996
Paracetamol with and without codeine in acute pain: a quantitative systematic review.
    Pain, 1997, Volume: 70, Issue:2-3

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, C

1997
Use of carprofen for the treatment of pain and inflammation in dogs.
    Journal of the American Veterinary Medical Association, 1997, May-15, Volume: 210, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1997
The management of chronic pain in patients with breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Society of Palliative Care Physicians. Canadian Association of Radiation Oncologist
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1998, Feb-10, Volume: 158 Suppl 3

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, L

1998
Non-NSAID pharmacologic treatment options for the management of chronic pain.
    The American journal of medicine, 1998, Jul-27, Volume: 105, Issue:1B

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1998
Co-proxamol or paracetamol for acute pain?
    Drug and therapeutics bulletin, 1998, Volume: 36, Issue:10

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Dextropropoxyphene; Drug Combinations; Human

1998
Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine.
    Annals of internal medicine, 1999, Jul-06, Volume: 131, Issue:1

    Topics: Acetaminophen; Drug Administration Schedule; Humans; Narcotics; Nausea; Neoplasms; Pain; Pain Manage

1999
Non-opioid postoperative analgesia.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:10

    Topics: Acetaminophen; Adrenergic alpha-Agonists; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroida

2000
Nonsteroidal anti-inflammatory drugs: overused or underused in osteoarthritis?
    The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Prescriptions

2001
The role of acetaminophen in the management of patients with osteoarthritis.
    The American journal of medicine, 2001, Feb-19, Volume: 110 Suppl 3A

    Topics: Acetaminophen; Activities of Daily Living; Age Distribution; Aged; Analgesics, Non-Narcotic; Anti-In

2001
Pain management for neonatal circumcision.
    Paediatric drugs, 2001, Volume: 3, Issue:2

    Topics: Acetaminophen; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Hum

2001
Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Clinical Trials as Topic; Fever; Humans; Liver;

2000
Paracetamol efficacy and safety in children: the first 40 years.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Nonprescription Drugs; Pain

2000
Paracetamol: past, present, and future.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Pain

2000
Update on pain management for advanced genitourinary cancer.
    The Journal of urology, 2001, Volume: 165, Issue:6 Pt 1

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Humans;

2001
Treatment of chronic pain in osteoarthritis: do opioids have a clinical role?
    Current rheumatology reports, 2001, Volume: 3, Issue:6

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Opioid-Related D

2001
Chronic pain in the older patient: management strategies. 2.
    Journal of gerontological nursing, 2002, Volume: 28, Issue:2

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antide

2002
Pyoderma gangrenosum: a case study for pain management in dermatology nursing.
    Dermatology nursing, 2000, Volume: 12, Issue:5

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Joint Commission on A

2000
Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol).
    Current pharmaceutical design, 2002, Volume: 8, Issue:12

    Topics: Acetaminophen; Analgesia; Cardiovascular System; Celecoxib; Clinical Trials as Topic; Cyclooxygenase

2002
Effective use of analgesic drugs.
    Annual review of medicine, 1976, Volume: 27

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast

1976
Acetaminophen.
    Annals of internal medicine, 1977, Volume: 87, Issue:2

    Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic;

1977
Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity.
    Pediatrics, 1978, Volume: 62, Issue:5 Pt 2 Sup

    Topics: Acetaminophen; Aspirin; Body Temperature; Fever; Humans; Hypothalamus; Pain

1978
Simple analgesics.
    Drugs, 1975, Volume: 10, Issue:5-6

    Topics: Acetaminophen; Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Drug Combi

1975
Pain in neonatal circumcision.
    Clinical pediatrics, 1991, Volume: 30, Issue:7

    Topics: Acetaminophen; Anesthesia, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Nerve Block; Pa

1991
Pharmacologic management of pain in children and adolescents.
    Pediatric clinics of North America, 1989, Volume: 36, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

1989
Oral meptazinol--United Kingdom experience.
    Postgraduate medical journal, 1985, Volume: 61 Suppl 2

    Topics: Acetaminophen; Adult; Aged; Azepines; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Met

1985

Trials

345 trials available for acetaminophen and Ache

ArticleYear
Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:1

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Asian People; Biotransformation; Chronic Disea

2007
The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial.
    Journal of the World federation of orthodontists, 2022, Volume: 11, Issue:3

    Topics: Acetaminophen; Caffeine; Female; Humans; Low-Level Light Therapy; Male; Malocclusion, Angle Class I;

2022
The experience of pain in real-time during medication abortion.
    Contraception, 2022, Volume: 110

    Topics: Abortion, Induced; Acetaminophen; Analgesics; Analgesics, Opioid; Female; Humans; Ibuprofen; Mifepri

2022
The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media.
    International journal of pediatric otorhinolaryngology, 2022, Volume: 156

    Topics: Acetaminophen; Acute Disease; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Earache; H

2022
Effect of combined paracetamol and dexamethasone vs. paracetamol on postoperative nausea vomiting after cesarean section.
    Journal of perinatal medicine, 2022, Oct-26, Volume: 50, Issue:8

    Topics: Acetaminophen; Antiemetics; Cesarean Section; Dexamethasone; Double-Blind Method; Female; Humans; Pa

2022
Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study.
    BMC emergency medicine, 2022, 07-07, Volume: 22, Issue:1

    Topics: Acetaminophen; Administration, Inhalation; Adult; Ambulances; Analgesia; Analgesics; Anesthetics, In

2022
Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions.
    Pediatric emergency care, 2022, Aug-01, Volume: 38, Issue:8

    Topics: Acetaminophen; Administration, Intranasal; Analgesics, Opioid; Child; Child, Preschool; Communicable

2022
The Effect of Thunder-Fire Moxibustion on Lumbar Disc Herniation: Study Protocol for a Randomized Controlled Trial.
    Frontiers in public health, 2022, Volume: 10

    Topics: Acetaminophen; Humans; Intervertebral Disc Displacement; Moxibustion; Pain; Quality of Life; Randomi

2022
Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up.
    Clinics (Sao Paulo, Brazil), 2022, Volume: 77

    Topics: Acetaminophen; Double-Blind Method; Female; Follow-Up Studies; Humans; Injections, Intra-Articular;

2022
An international, open-label, randomised trial comparing a two-step approach versus the standard three-step approach of the WHO analgesic ladder in patients with cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2022, Volume: 33, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Humans; Neoplasms; Pain; World Health Organization

2022
Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study.
    Wilderness & environmental medicine, 2022, Volume: 33, Issue:4

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Huma

2022
Intravenous paracetamol for persistent pain after endoscopic mucosal resection discriminates patients at risk of adverse events and those who can be safely discharged.
    Endoscopy, 2023, Volume: 55, Issue:7

    Topics: Acetaminophen; Colonoscopy; Endoscopic Mucosal Resection; Female; Fentanyl; Humans; Pain; Patient Di

2023
A Randomized Trial Comparing Intravenous Paracetamol, Topical Lidocaine, and Ice Application for Treatment of Pain Associated with Scorpion Stings: Some Concerns.
    Wilderness & environmental medicine, 2023, Volume: 34, Issue:2

    Topics: Acetaminophen; Humans; Ice; Lidocaine; Pain; Scorpion Stings

2023
Acetaminophen changes Mu rhythm power related to pain empathy.
    Neuropsychologia, 2023, 06-06, Volume: 184

    Topics: Acetaminophen; Electroencephalography; Emotions; Empathy; Humans; Pain

2023
Effect of eye shield and ear muffs on pain intensity during venous blood sampling in premature infants: a clinical trial study.
    BMC pediatrics, 2023, 04-06, Volume: 23, Issue:1

    Topics: Acetaminophen; Child; Humans; Infant, Newborn; Infant, Premature; Pain; Pain Measurement; Phlebotomy

2023
Effectiveness and safety of prehospital analgesia including nalbuphine and paracetamol by paramedics: an observational study.
    Minerva anestesiologica, 2023, Volume: 89, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics; Butylscopolammonium Bromide; Emergency Medi

2023
Lidocaine infusion has a 25% opioid-sparing effect on background pain after burns: A prospective, randomised, double-blind, controlled trial.
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:2

    Topics: Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; A

2020
Intravenous versus subcutaneous route pharmacokinetics of paracetamol (acetaminophen) in palliative care patients: study protocol for a randomized trial (ParaSCIVPallia).
    Trials, 2020, Feb-04, Volume: 21, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cross-Over Stud

2020
Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial.
    Clinical oral investigations, 2021, Volume: 25, Issue:3

    Topics: Abscess; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Double-Blind Method;

2021
Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol.
    BMJ open, 2020, 12-10, Volume: 10, Issue:12

    Topics: Acetaminophen; Asthma; Child; Child, Preschool; Humans; Ibuprofen; Infant; Infant, Newborn; Multicen

2020
Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial.
    BMC medicine, 2020, 12-21, Volume: 18, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Cross-Over Studies; Dementia; Disease Progression; Double-Bl

2020
Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants.
    Clinical therapeutics, 2021, Volume: 43, Issue:6

    Topics: Acetaminophen; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Vo

2021
Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat.
    International journal of clinical practice, 2021, Volume: 75, Issue:10

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketoprofen; Pai

2021
Randomized Controlled Trial Comparing Different Single Doses of Intravenous Paracetamol for Placement of Peripherally Inserted Central Catheters in Preterm Infants.
    Neonatology, 2017, Volume: 112, Issue:2

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Catheterization, Central Venou

2017
Correlation of Pain Reduction with fMRI BOLD Response in Osteoarthritis Patients Treated with Paracetamol: Randomized, Double-Blind, Crossover Clinical Efficacy Study.
    Pain medicine (Malden, Mass.), 2018, 02-01, Volume: 19, Issue:2

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain; Cross-Over Studies; Delayed-Action Preparation

2018
Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study.
    Current medical research and opinion, 2018, Volume: 34, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Double-Blind Method; Fem

2018
Intravenous versus oral paracetamol for acute pain in adults in the emergency department setting: a prospective, double-blind, double-dummy, randomised controlled trial.
    Emergency medicine journal : EMJ, 2018, Volume: 35, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Double-Blind Method; Emerge

2018
Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial.
    International journal of geriatric psychiatry, 2018, Volume: 33, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesics; Buprenorphine; Dementia; Depressive Disorder; Double-Blind M

2018
Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial.
    PloS one, 2018, Volume: 13, Issue:2

    Topics: Acetaminophen; Administration, Oral; Analgesics; Double-Blind Method; Female; Humans; Ibuprofen; Inf

2018
Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial.
    American journal of obstetrics and gynecology, 2018, Volume: 218, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St

2018
Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
    Balkan medical journal, 2018, 07-24, Volume: 35, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dysmenorrhea; Female; H

2018
Evaluating drugged driving: Effects of exemplar pain and anxiety medications.
    Traffic injury prevention, 2018, 02-28, Volume: 19, Issue:sup1

    Topics: Acetaminophen; Adult; Alprazolam; Anxiety; Cross-Over Studies; Double-Blind Method; Driving Under th

2018
Double-blind placebo-controlled randomized clinical trial on the use of paracetamol for performing mammography.
    Medicine, 2018, Volume: 97, Issue:13

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Mammograp

2018
Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.
    European journal of pain (London, England), 2018, Volume: 22, Issue:7

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Allergic Agents; Attention; Cognition; Cold Tem

2018
Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2018, Volume: 38, Issue:8

    Topics: Acetaminophen; Adult; Amniocentesis; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans;

2018
[In process].
    Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:10

    Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe

2016
Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients.
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018, Volume: 27, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Elective Surgical Procedures; Fem

2018
The Influence of Acetaminophen and Observational Conditioning on the Acquired Capability for Suicide.
    Behavior therapy, 2018, Volume: 49, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Conditioning, Psychological; Female; Humans; Male; M

2018
Evaluating the use of intra-articular injections as a treatment for painful hip osteoarthritis: a randomized, double-blind, multicenter, parallel-group study comparing a single 6-mL injection of hylan G-F 20 with saline.
    Osteoarthritis and cartilage, 2019, Volume: 27, Issue:1

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Therapy, Com

2019
Study of glutathione S-transferase levels in patients receiving intravenous paracetamol perioperatively: A randomized controlled trial.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018, Volume: 37, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Double-Blind M

2018
Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial.
    BMC geriatrics, 2018, 11-14, Volume: 18, Issue:1

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cross-Over Studies; Dementia; Depression; Double-Blin

2018
N-acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double-blind controlled trial in healthy subjects.
    Fundamental & clinical pharmacology, 2019, Volume: 33, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced

2019
Pain relief after orthodontic archwire installation-a comparison between intervention with paracetamol and chewing gum: a randomized controlled trial.
    European journal of orthodontics, 2019, 09-21, Volume: 41, Issue:5

    Topics: Acetaminophen; Adolescent; Chewing Gum; Child; Female; Humans; Male; Orthodontic Wires; Pain; Pain M

2019
A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain.
    The Angle orthodontist, 2019, Volume: 89, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Behavior Therapy; Double-Blind Method; Humans; Ibuprofen; P

2019
Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.
    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2019, 11-09, Volume: 53, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Forgiveness; Humans; In

2019
Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis.
    Clinical rheumatology, 2019, Volume: 38, Issue:10

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dulox

2019
Effects of pre-emptive analgesia on efficacy of buccal infiltration during pulpotomy of mandibular primary molars: a double-blinded randomized controlled trial.
    Acta odontologica Scandinavica, 2019, Volume: 77, Issue:7

    Topics: Acetaminophen; Analgesia; Child; Double-Blind Method; Humans; Ibuprofen; Molar; Pain; Pulpotomy; Too

2019
Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial.
    BMC anesthesiology, 2019, 06-11, Volume: 19, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Doub

2019
The common pain of surrealism and death: acetaminophen reduces compensatory affirmation following meaning threats.
    Psychological science, 2013, Volume: 24, Issue:6

    Topics: Acetaminophen; Adult; Death; Emotions; Fear; Female; Humans; Male; Motion Pictures; Pain; Placebo Ef

2013
The response of agitated behavior to pain management in persons with dementia.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014, Volume: 22, Issue:7

    Topics: Acetaminophen; Aged, 80 and over; Analgesics; Buprenorphine; Delayed-Action Preparations; Dementia;

2014
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study.
    BMC gastroenterology, 2013, Jul-01, Volume: 13

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu

2013
Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement.
    European journal of orthodontics, 2014, Volume: 36, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dinoprostone; Double-Blind Method; Femal

2014
Comparative study between 2 protocols for management of severe pain in patients with unresectable pancreatic cancer: one-year follow-up.
    The Clinical journal of pain, 2013, Volume: 29, Issue:9

    Topics: Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Autonomic Nerve Bloc

2013
Are all placebo effects equal? Placebo pills, sham acupuncture, cue conditioning and their association.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Acetaminophen; Acupuncture Points; Acupuncture Therapy; Adult; Analgesics, Non-Narcotic; Analysis of

2013
Take-Wait-Stop: a patient-centered strategy for writing PRN medication instructions.
    Journal of health communication, 2013, Volume: 18 Suppl 1

    Topics: Acetaminophen; Adult; Analgesics; Drug Labeling; Female; Health Literacy; Humans; Linear Models; Mal

2013
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2014, Volume: 24, Issue:7

    Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Analgesics,

2014
Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2014, Volume: 34, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blin

2014
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, and paracervical block application for pain relief during suction termination of first-trimester pregnancy.
    BioMed research international, 2013, Volume: 2013

    Topics: Abortion, Induced; Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Anesthes

2013
Efficacy of celecoxib in the treatment of joint pain caused by advanced haemophilic arthropathy in adult patients with haemophilia A.
    Haemophilia : the official journal of the World Federation of Hemophilia, 2014, Volume: 20, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase 2 In

2014
Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2014, Volume: 21, Issue:3

    Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Codeine; Double-Blind Method; Drug

2014
A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aminolevulinic Acid; Analgesics, Non-Narcoti

2014
A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia.
    Genetics and molecular research : GMR, 2014, Mar-19, Volume: 13, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesia, Epidural; Analgesics; Delayed-Action Preparat

2014
Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial.
    The Journal of bone and joint surgery. American volume, 2014, Apr-02, Volume: 96, Issue:7

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Bone Nails; Child; Child, Preschool;

2014
Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial.
    European journal of pain (London, England), 2014, Volume: 18, Issue:10

    Topics: Acetaminophen; Activities of Daily Living; Aged; Aged, 80 and over; Analgesics; Buprenorphine; Clini

2014
Evaluation of pain in office hysteroscopy with prior analgesic medication: a prospective randomized study.
    European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 178

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; Female; H

2014
A randomized, double-blind, placebo-controlled 12 week trial of acetaminophen extended release for the treatment of signs and symptoms of osteoarthritis.
    Current medical research and opinion, 2014, Volume: 30, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Delayed-Action Preparations; Double-Blind Meth

2014
Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Acetaminophen; Administration, Buccal; Adult; Analgesia; Cross-Over Studies; Dose-Response Relations

2014
A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings.
    Human & experimental toxicology, 2015, Volume: 34, Issue:6

    Topics: Acetaminophen; Administration, Intravenous; Administration, Topical; Adolescent; Adult; Aged; Aged,

2015
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:20

    Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2014
Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:2

    Topics: Acetaminophen; Adult; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-B

2015
The effect of intravenous paracetamol for the prevention of rocuronium injection pain.
    The Kaohsiung journal of medical sciences, 2014, Volume: 30, Issue:11

    Topics: Acetaminophen; Adult; Androstanols; Female; Humans; Injections, Intravenous; Male; Pain; Rocuronium

2014
A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis.
    Spine, 2015, May-15, Volume: 40, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu

2015
Improving patient knowledge and safe use of opioids: a randomized controlled trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2015, Volume: 22, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Adolescent; Adult; Analgesics, Opioid; Double-Blind Method;

2015
Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli.
    Psychological science, 2015, Volume: 26, Issue:6

    Topics: Acetaminophen; Affect; Analgesics, Non-Narcotic; Arousal; Humans; Nonprescription Drugs; Pain; Photi

2015
Efficacy of Single Dose Oral Paracetamol in Reducing Pain During Examination for Retinopathy of Prematurity: A Blinded Randomized Controlled Trial.
    Indian journal of pediatrics, 2016, Volume: 83, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anesthetics, Local; Crying; Double-Bl

2016
Comparative Analgesic Efficacy of Oxycodone/Acetaminophen vs Codeine/Acetaminophen for Short-Term Pain Management Following ED Discharge.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combinati

2015
The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain; Cross-Over Studies; Double-Blind Method; Evok

2015
Long-term use of minimal footwear on pain, self-reported function, analgesic intake, and joint loading in elderly women with knee osteoarthritis: A randomized controlled trial.
    Clinical biomechanics (Bristol, Avon), 2015, Volume: 30, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analysis of Variance; Disability E

2015
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
    Progress in orthodontics, 2015, Volume: 16

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2015
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
    Progress in orthodontics, 2015, Volume: 16

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2015
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
    Progress in orthodontics, 2015, Volume: 16

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2015
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
    Progress in orthodontics, 2015, Volume: 16

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2015
Efficacy and safety of low-dose SoluMatrix meloxicam in the treatment of osteoarthritis pain: a 12-week, phase 3 study.
    Current medical research and opinion, 2015, Volume: 31, Issue:12

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind

2015
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial.
    The Indian journal of medical research, 2015, Volume: 142, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesia; Curettage; Diclofenac; Female; Gynecologic Surgical Procedure

2015
Intravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled study.
    The Kaohsiung journal of medical sciences, 2015, Volume: 31, Issue:11

    Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Biopsy; Demography; Double-Blin

2015
Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial.
    Acta neurologica Belgica, 2016, Volume: 116, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinat

2016
Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer.
    Auris, nasus, larynx, 2016, Volume: 43, Issue:6

    Topics: Acetaminophen; Adult; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Carcinoma

2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
    Journal of endodontics, 2016, Volume: 42, Issue:6

    Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
    Journal of endodontics, 2016, Volume: 42, Issue:6

    Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
    Journal of endodontics, 2016, Volume: 42, Issue:6

    Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
    Journal of endodontics, 2016, Volume: 42, Issue:6

    Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-

2016
From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain.
    Social cognitive and affective neuroscience, 2016, Volume: 11, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Empathy; Female; Humans; Male; Noise;

2016
Efficacy of Plai Cream in Adult Patients with Muscle Strain: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2016, Volume: 99 Suppl 2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method

2016
Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial.
    Acta medica Iranica, 2016, Volume: 54, Issue:7

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Female; Humans; Ibuprofen

2016
Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 359, Issue:1

    Topics: Acetaminophen; Calcium; Cell Membrane; Electrophysiological Phenomena; Female; HEK293 Cells; Humans;

2016
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
    The New England journal of medicine, 2016, Aug-18, Volume: 375, Issue:7

    Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci

2016
Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial.
    Journal of endodontics, 2016, Volume: 42, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Dental; Anesthesia,

2016
Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017, Volume: 26, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthriti

2017
Comparison of iatrogenic pain between rotavirus vaccination before and after vaccine injection in 2-month-old infants.
    Human vaccines & immunotherapeutics, 2017, 05-04, Volume: 13, Issue:5

    Topics: Acetaminophen; Administration, Oral; Analgesics; Crying; Female; Humans; Infant; Injections; Logisti

2017
Nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol do not affect 6-month mood-stabilizing treatment outcome among 482 patients with bipolar disorder.
    Depression and anxiety, 2017, Volume: 34, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2017
Premedication to reduce discomfort during screening mammography.
    Radiology, 2008, Volume: 248, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen

2008
Atorvastatin may have no effect on acute phase reaction in children after intravenous bisphosphonate infusion.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2009, Volume: 24, Issue:2

    Topics: Acetaminophen; Acute-Phase Reaction; Anticholesteremic Agents; Atorvastatin; Bone Density Conservati

2009
Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2009, Volume: 17, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind M

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 135, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr

2009
Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa
    Clinical therapeutics, 2009, Volume: 31, Issue:3

    Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Anal

2009
Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010, Volume: 18, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi

2010
Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
    Clinical drug investigation, 2009, Volume: 29 Suppl 1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid;

2009
Oral administration of analgesia and anxiolysis for pain associated with bone marrow biopsy.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010, Volume: 18, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia, Local;

2010
Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2009, Volume: 16, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co

2009
Randomized double-blind placebo controlled crossover study of acetaminophen, ibuprofen, acetaminophen/hydrocodone, and placebo for the relief of pain from a standard painful stimulus.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2009, Volume: 16, Issue:9

    Topics: Acetaminophen; Acute Disease; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations

2009
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
    Annals of emergency medicine, 2009, Volume: 54, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind

2009
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
    Annals of emergency medicine, 2009, Volume: 54, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind

2009
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
    Annals of emergency medicine, 2009, Volume: 54, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind

2009
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
    Annals of emergency medicine, 2009, Volume: 54, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind

2009
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:3

    Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti

2010
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:3

    Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti

2010
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:3

    Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti

2010
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:3

    Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti

2010
Effects of high dose orally administered paracetamol for heel prick pain in premature infants.
    Saudi medical journal, 2009, Volume: 30, Issue:11

    Topics: Acetaminophen; Administration, Oral; Chi-Square Distribution; Dose-Response Relationship, Drug; Doub

2009
Influence of acetaminophen on performance during time trial cycling.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 108, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bicycling; Double-Blind Method; Exercise Test; Human

2010
Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures.
    Emergency medicine Australasia : EMA, 2009, Volume: 21, Issue:6

    Topics: Acetaminophen; Acute Disease; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analysis of Var

2009
Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.
    Arthritis research & therapy, 2009, Volume: 11, Issue:6

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements

2009
...And what's best for fracture pain in children?
    Child health alert, 2009, Volume: 27

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Codeine; Drug Combin

2009
Lack of benefit from paracetamol (acetaminophen) for palliative cancer patients requiring high-dose strong opioids: a randomized, double-blind, placebo-controlled, crossover trial.
    Journal of pain and symptom management, 2010, Volume: 39, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Studies; Double

2010
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
    Osteoarthritis and cartilage, 2010, Volume: 18, Issue:5

    Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis

2010
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
    Osteoarthritis and cartilage, 2010, Volume: 18, Issue:5

    Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis

2010
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
    Osteoarthritis and cartilage, 2010, Volume: 18, Issue:5

    Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis

2010
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
    Osteoarthritis and cartilage, 2010, Volume: 18, Issue:5

    Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis

2010
Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol representing three different groups of analgesics for pain control in extracorporeal shockwave lithotripsy.
    Journal of endourology, 2010, Volume: 24, Issue:4

    Topics: Acetaminophen; Adult; Analgesics; Demography; Female; Humans; Lithotripsy; Male; Middle Aged; Pain;

2010
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote

2010
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote

2010
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote

2010
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote

2010
A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis.
    International journal of rheumatic diseases, 2009, Volume: 12, Issue:1

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Double-Blind Method; Dr

2009
Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients.
    International orthopaedics, 2011, Volume: 35, Issue:9

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Female;

2011
Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries.
    Archives of disease in childhood. Education and practice edition, 2010, Volume: 95, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co

2010
Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation.
    The Clinical journal of pain, 2010, Volume: 26, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Double-Blind Method

2010
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
    Postgraduate medicine, 2010, Volume: 122, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Diseas

2010
Acetaminophen plus codeine compared to ketorolac in polytrauma patients.
    European review for medical and pharmacological sciences, 2010, Volume: 14, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents,

2010
Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy.
    Diabetic medicine : a journal of the British Diabetic Association, 2010, Volume: 27, Issue:9

    Topics: Acetaminophen; Adult; Aged; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Diabetes Mellit

2010
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2010, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl

2010
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2010, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl

2010
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2010, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl

2010
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2010, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl

2010
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum

2011
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum

2011
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum

2011
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum

2011
Pain management in young children undergoing diagnostic tympanocentesis.
    Clinical pediatrics, 2011, Volume: 50, Issue:3

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Biopsy, Fine-Needle; Chi

2011
Safety of multiple-dose intravenous acetaminophen in adult inpatients.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Fever; Humans; Injections, Intravenous; Pain; Prospe

2010
Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model.
    The Clinical journal of pain, 2011, Volume: 27, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Codei

2011
Effects of analgesics on orthodontic pain.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2011, Volume: 139, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2011
Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial.
    Journal of clinical pharmacy and therapeutics, 2012, Volume: 37, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Bone Neopla

2012
Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures.
    Journal of neurosurgery. Spine, 2011, Volume: 14, Issue:5

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat

2011
Epidemiological data, efficacy and safety of a paracetamol-tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practice.
    Current medical research and opinion, 2011, Volume: 27, Issue:5

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Female; Humans

2011
Tropisetron blocks analgesic action of acetaminophen: a human pain model study.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents; Cross-Over

2011
Randomised controlled trial comparing oral and intravenous paracetamol (acetaminophen) plasma levels when given as preoperative analgesia.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Female; Huma

2011
Medical expulsive therapy using alfuzosin for patient presenting with ureteral stone less than 10mm: a prospective randomized controlled trial.
    International journal of urology : official journal of the Japanese Urological Association, 2011, Volume: 18, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents,

2011
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 109, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over

2011
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain.
    Annals of the rheumatic diseases, 2011, Volume: 70, Issue:9

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respo

2011
The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID).
    Clinical rheumatology, 2012, Volume: 31, Issue:2

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female;

2012
A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians.
    Italian journal of pediatrics, 2011, Sep-29, Volume: 37

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Anti-

2011
Paracetamol and opioid pathways: a pilot randomized clinical trial.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cross-Over Studies; Double-Bli

2013
Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response.
    The Journal of pediatrics, 2013, Volume: 162, Issue:1

    Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Double-Blind Method; Extraction, Ob

2013
Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Delivery, Obstetric; Do

2013
The effect of paracetamol and tropisetron on pain: experimental studies and a review of published data.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cross-Over Studies; Double-Blind Method; Dr

2013
A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice.
    Laboratory animals, 2012, Volume: 46, Issue:4

    Topics: Abdomen; Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal;

2012
A novel paracetamol 1,000 mg sustained release formulation vs conventional paracetamol 500 mg formulation in patients with fever and pain: a randomized noninferiority trial.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antipyretics; Delayed-Action Prepa

2013
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid;

2002
Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies.
    Clinical therapeutics, 2002, Volume: 24, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over

2002
Changes in size of periarthritis calcifications in patients with painful shoulder treated with injectable disodium-clodronate.
    International journal of clinical pharmacology research, 2002, Volume: 22, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Calcinosis; Clodro

2002
Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain.
    International journal of clinical practice, 2002, Volume: 56, Issue:10

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Co

2002
Prospective study on incidence and functional impact of transient neurologic symptoms associated with 1% versus 5% hyperbaric lidocaine in short urologic procedures.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics,

2003
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
    The American journal of medicine, 2003, Volume: 114, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug

2003
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
    The American journal of medicine, 2003, Volume: 114, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug

2003
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
    The American journal of medicine, 2003, Volume: 114, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug

2003
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
    The American journal of medicine, 2003, Volume: 114, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug

2003
Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol.
    East African medical journal, 2000, Volume: 77, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Male

2000
Intravenous corticosteroids to reduce gemtuzumab ozogamicin infusion reactions.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:9

    Topics: Acetaminophen; Adult; Aminoglycosides; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflamm

2003
Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol.
    International immunopharmacology, 2003, Volume: 3, Issue:13-14

    Topics: Acetaminophen; Administration, Oral; Aged; Double-Blind Method; Female; Humans; Interleukin-6; Male;

2003
Is there an additive analgesic effect of paracetamol at step 3? A double-blind randomized controlled study.
    Palliative medicine, 2003, Volume: 17, Issue:8

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Delayed

2003
Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial.
    The Journal of rheumatology, 2004, Volume: 31, Issue:1

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors;

2004
Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects.
    International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Biological Availability; Chemistry

2004
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:3

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2004
Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life.
    Current medical research and opinion, 2004, Volume: 20, Issue:2

    Topics: Acetaminophen; Activities of Daily Living; Administration, Cutaneous; Aged; Aged, 80 and over; Analg

2004
[Treatment of functional signs of acute maxillary rhinosinusitis in adults. Efficacy and tolerance of administration of oral prednisone for 3 days].
    Presse medicale (Paris, France : 1983), 2004, Mar-13, Volume: 33, Issue:5

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-In

2004
Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial.
    Current medical research and opinion, 2004, Volume: 20, Issue:6

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics; Dose-Response Relationship, Drug; Doubl

2004
A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:7

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cross-Over Studies; Dementia; Doub

2004
Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthenia; Chills; Double-Blind Method; Drug Administ

2004
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-15, Volume: 22, Issue:16

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu

2004
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-15, Volume: 22, Issue:16

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu

2004
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-15, Volume: 22, Issue:16

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu

2004
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-15, Volume: 22, Issue:16

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu

2004
Continuous low-level heat wrap therapy is effective for treating wrist pain.
    Archives of physical medicine and rehabilitation, 2004, Volume: 85, Issue:9

    Topics: Acetaminophen; Activities of Daily Living; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bandag

2004
Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Area Under

2004
Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2004, Volume: 11, Issue:12

    Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Bli

2004
A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2004, Volume: 10, Issue:6

    Topics: Acetaminophen; Adjuvants, Immunologic; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, No

2004
[Results of an open prospective controlled randomized comparative trial of efficacy and tolerance of sublingual tablets flurbiprofen (strepfen) and paracetamol in patients with throat pain in acute infectious-inflammatory diseases of the upper respiratory
    Vestnik otorinolaringologii, 2004, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Hypersensitivity; Flurbiprofen; Humans; Pain; Prospect

2004
A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data.
    Pharmacoepidemiology and drug safety, 2005, Volume: 14, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Aspirin; Female; Humans; Ibuprofen; Male; Middle

2005
[Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain].
    Terapevticheskii arkhiv, 2005, Volume: 77, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Female; Flurbiprofen; Humans; Male

2005
The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain.
    Current medical research and opinion, 2005, Volume: 21, Issue:1

    Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varia

2005
Paravertebral block with ropivacaine 0.5% versus systemic analgesia for pain relief after thoracotomy.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:6

    Topics: Acetaminophen; Adult; Aged; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics,

2005
Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies.
    The Journal of rheumatology, 2005, Volume: 32, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response

2005
Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients.
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:4

    Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic;

2005
Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen.
    Arthritis and rheumatism, 2005, Aug-15, Volume: 53, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind M

2005
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
    Annals of emergency medicine, 2005, Volume: 46, Issue:4

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans

2005
Paediatric cancer pain management using the WHO analgesic ladder--results of a prospective analysis from 2265 treatment days during a quality improvement study.
    European journal of pain (London, England), 2006, Volume: 10, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics; Analgesics, Opioid; Antineoplastic Agents;

2006
Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial.
    Pediatrics, 2006, Volume: 117, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M

2006
Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees.
    Rheumatology (Oxford, England), 2006, Volume: 45, Issue:11

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Huma

2006
Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee.
    The American journal of managed care, 2006, Volume: 12, Issue:4

    Topics: Acetaminophen; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Therapy, Combination; Humans

2006
Erythromycin promotes gastric emptying during acute pain in volunteers.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:6

    Topics: Acetaminophen; Acute Disease; Adult; Breath Tests; Caprylates; Cold Temperature; Cross-Over Studies;

2006
Pre-surgical child behavior ratings and pain management after two different techniques of tonsil surgery.
    International journal of pediatric otorhinolaryngology, 2006, Volume: 70, Issue:10

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Anti-Inflammato

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial.
    The Journal of urology, 2006, Volume: 176, Issue:4 Pt 1

    Topics: Acetaminophen; Administration, Oral; Aged; Analgesics; Anesthetics, Local; Biopsy, Needle; Double-Bl

2006
A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.
    Neurology, 2006, Oct-24, Volume: 67, Issue:8

    Topics: Acetaminophen; Adrenergic Uptake Inhibitors; Aged; Analgesics, Non-Narcotic; Diabetic Neuropathies;

2006
Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat.
    Clinical therapeutics, 2006, Volume: 28, Issue:9

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesia; Analgesics, Non-Narcotic; Doub

2006
Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection.
    Current medical research and opinion, 2006, Volume: 22, Issue:12

    Topics: Acetaminophen; Adult; Double-Blind Method; Drug Therapy, Combination; Ephedrine; Female; Humans; Mal

2006
Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial.
    Clinical therapeutics, 2006, Volume: 28, Issue:12

    Topics: Acetaminophen; Adult; Aged; Analgesics; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Me

2006
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics

2007
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Area Under Curve; Caffeine; Central Nerv

2007
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
    BMC medicine, 2007, May-30, Volume: 5

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspart

2007
Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:9

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents, Non-S

2007
Effects of paracetamol combined with dextromethorphan in human experimental muscle and skin pain.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Drug Therapy, Combi

2007
Supra-additive effects of tramadol and acetaminophen in a human pain model.
    Pain, 2008, Volume: 136, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Computer Simulation; Cross-Over

2008
A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain.
    Clinical therapeutics, 2007, Volume: 29, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics; Double-Blind Method; Drug Administration Schedule; Drug Comb

2007
Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain.
    British journal of anaesthesia, 2008, Volume: 100, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Anesthetics, Local; Double

2008
Analgesic effect of paracetamol on cancer related pain in concurrent strong opioid therapy. A prospective clinical study.
    Acta oncologica (Stockholm, Sweden), 2008, Volume: 47, Issue:5

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Administr

2008
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].
    BMC complementary and alternative medicine, 2007, Oct-31, Volume: 7

    Topics: Acetaminophen; Double-Blind Method; Female; Glucosamine; Humans; Insulin-Like Growth Factor I; Male;

2007
Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study.
    Clinical therapeutics, 2007, Volume: 29, Issue:10

    Topics: Acetaminophen; Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, No

2007
The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium.
    Saudi medical journal, 2007, Volume: 28, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroi

2007
Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study.
    Fertility and sterility, 2009, Volume: 91, Issue:5

    Topics: Abortion, Induced; Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Age

2009
A comparison of aspirin and paracetamol.
    British journal of anaesthesia, 1967, Volume: 39, Issue:2

    Topics: Acetaminophen; Adult; Aspirin; Humans; Male; Nursing Service, Hospital; Orthopedics; Pain; Placebos

1967
Analgesia following oral surgery: a comparative study of Solpadeine and a soluble form of dextropropoxyphene napsylate and paracetamol.
    The Journal of international medical research, 1983, Volume: 11, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Caffeine; Codeine; Dextropropoxyphene; Drug Combinations; Female;

1983
Analgesic efficacy of dextropropoxyphene and dextropropoxyphene-containing combinations: a review.
    Human toxicology, 1984, Volume: 3 Suppl

    Topics: Acetaminophen; Aminoacridines; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Chlorambucil

1984
A double-blind comparison in general practice of a combination tablet containing orphenadrine citrate and paracetamol ('Norgesic') with paracetamol alone.
    The Journal of international medical research, 1983, Volume: 11, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Back Pain; Bone Diseases; Double-Blind Method; Drug Combinat

1983
[Evaluation of the analgesic effect of UP 341-01 in patients presenting with acute pain in ORL].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Oct-27, Volume: 59, Issue:39

    Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injection

1983
[Effect of orphenadrine/paracetamol combination tablets (Norgesic) on myalgia. A double-blind comparative study using a placebo in general practice].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1983, Feb-28, Volume: 103, Issue:6

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Huma

1983
Report of a double-blind crossover study to compare flurbiprofen with paracetamol in the treatment of primary dysmenorrhoea.
    The Journal of international medical research, 1983, Volume: 11 Suppl 2

    Topics: Acetaminophen; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Hu

1983
Transcutaneous electrical nerve stimulation in osteoarthrosis: a therapeutic alternative?
    Annals of the rheumatic diseases, 1984, Volume: 43, Issue:1

    Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Electric Stimulation Ther

1984
Caffeine as an analgesic adjuvant.
    JAMA, 1984, Apr-06, Volume: 251, Issue:13

    Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou

1984
Distalgesic; safety and efficacy. Efficacy: UK experience.
    Human toxicology, 1984, Volume: 3 Suppl

    Topics: Acetaminophen; Apazone; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Drug Combin

1984
Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea.
    British journal of obstetrics and gynaecology, 1984, Volume: 91, Issue:11

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; I

1984
Clinical trial of flupirtine maleate in patients with migraine.
    Current medical research and opinion, 1984, Volume: 9, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aminopyridines; Clinical Trials as Top

1984
A comparison between meptazinol and dextropropoxyphene plus paracetamol in elderly patients with musculoskeletal pains.
    Current medical research and opinion, 1984, Volume: 9, Issue:4

    Topics: Acetaminophen; Aged; Azepines; Bone Diseases; Clinical Trials as Topic; Dextropropoxyphene; Drug Com

1984
A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea.
    The Journal of international medical research, 1983, Volume: 11 Suppl 2

    Topics: Acetaminophen; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Dysmenorrhe

1983
A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain.
    The Journal of international medical research, 1984, Volume: 12, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev

1984
Effect of a combination of orphenadrine/paracetamol tablets ('Norgesic') on myalgia: a double-blind comparison with placebo in general practice.
    Current medical research and opinion, 1983, Volume: 8, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Aged; Double-Blind Method; Drug Combinations; Female; Humans; Male

1983
Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis.
    Current medical research and opinion, 1983, Volume: 8, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Combinations; Humans; Metoclopr

1983
Diflunisal. A new oral analgesic with an unusually long duration of action.
    JAMA, 1982, Nov-05, Volume: 248, Issue:17

    Topics: Acetaminophen; Administration, Oral; Clinical Trials as Topic; Codeine; Delayed-Action Preparations;

1982
A comparison of three ways of measuring pain.
    Rheumatology and rehabilitation, 1982, Volume: 21, Issue:4

    Topics: Acetaminophen; Aged; Apazone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomet

1982
[Analgesic, antipyretic and anti-rheumatic activity of 2 preparations evaluated in a multicenter clinical trial].
    La Clinica terapeutica, 1982, Dec-15, Volume: 103, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Clinical Trials

1982
Visual analogue scale and the analysis of analgesic action.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:4

    Topics: Acetaminophen; Adult; Analgesics; Codeine; Double-Blind Method; Drug Combinations; Humans; Male; Pai

1983
Comparative analgesic efficacies of aspirin and acetaminophen.
    Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No

    Topics: Acetaminophen; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Inflamma

1981
A double-blind comparison of meptazinol versus distalgesic in acute of chronic pain presenting to the general practitioner.
    The Journal of international medical research, 1982, Volume: 10, Issue:2

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Azepines; Chronic Disease; Dextropropoxyphene

1982
A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner.
    Current medical research and opinion, 1982, Volume: 8, Issue:3

    Topics: Acetaminophen; Acute Disease; Adult; Azepines; Chronic Disease; Double-Blind Method; Female; Humans;

1982
Methodological considerations in the evaluation of analgesic combinations: acetaminophen (paracetamol) and hydrocodone in postpartum pain.
    British journal of clinical pharmacology, 1980, Volume: 10 Suppl 2

    Topics: Acetaminophen; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Hu

1980
Comparative study of mefenamic acid and dextropropoxyphene plus paracetamol in an accident and emergency department.
    Current medical research and opinion, 1980, Volume: 7, Issue:2

    Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Dextropropoxyphene; Double-Blind Method; Drug The

1980
Intravenous regional anesthesia using lidocaine and ketorolac.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla

1995
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
    Anesthesiology, 1994, Volume: 81, Issue:4

    Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans

1994
Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.
    Annals of the rheumatic diseases, 1994, Volume: 53, Issue:8

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug

1994
n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis.
    BMJ (Clinical research ed.), 1994, Oct-22, Volume: 309, Issue:6961

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia; Capsules; Diclofenac; Double-Blind Method;

1994
Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol.
    International journal of tissue reactions, 1993, Volume: 15, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Clonixin; Double-Blind Method; Female; Humans; L

1993
Acetaminophen analgesia in neonatal circumcision: the effect on pain.
    Pediatrics, 1994, Volume: 93, Issue:4

    Topics: Acetaminophen; Circumcision, Male; Double-Blind Method; Humans; Infant, Newborn; Intraoperative Peri

1994
Effects of acetaminophen on adverse effects of influenza vaccination in health care workers.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1993, Nov-15, Volume: 149, Issue:10

    Topics: Acetaminophen; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Influenza Vacc

1993
Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients.
    Acta orthopaedica Scandinavica, 1993, Volume: 64, Issue:3

    Topics: Acetaminophen; Activities of Daily Living; Aged; Aged, 80 and over; Double-Blind Method; Drug Therap

1993
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
    European journal of anaesthesiology, 1993, Volume: 10, Issue:2

    Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In

1993
A placebo-controlled model for assaying systemic analgesics in children.
    Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:5

    Topics: Acetaminophen; Child; Child, Preschool; Double-Blind Method; Female; Humans; Ibuprofen; Male; Pain;

1993
Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial.
    Pain, 1995, Volume: 62, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Codeine; Cros

1995
A prospective comparison of transnasal butorphanol and acetaminophen with codeine for the relief of acute musculoskeletal pain.
    The American journal of emergency medicine, 1997, Volume: 15, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Butorphanol; Humans; Musculoskeletal Di

1997
Analgesia following arthroscopy--a comparison of intra-articular morphine, pethidine and fentanyl.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:1 Pt 1

    Topics: Acetaminophen; Adult; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General;

1997
The efficacy of tepid sponge bathing to reduce fever in young children.
    The American journal of emergency medicine, 1997, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Baths; Body Temperature; Child; Child, Preschool; Combined

1997
Dose-related effects of oral acetaminophen on cold-induced pain: a double-blind, randomized, placebo-controlled trial.
    Clinical pharmacology and therapeutics, 1998, Volume: 63, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cold Tem

1998
Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures.
    European journal of anaesthesiology, 1998, Volume: 15, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi

1998
Basal hormone levels in women who use acetaminophen for menstrual pain.
    Fertility and sterility, 1998, Volume: 70, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Basal Metabolism; Estradiol; Female; Fertilization i

1998
Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial.
    Annals of emergency medicine, 1998, Volume: 32, Issue:2

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcoti

1998
Randomised controlled trial of paracetamol for heel prick pain in neonates.
    Archives of disease in childhood. Fetal and neonatal edition, 1998, Volume: 79, Issue:3

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Blood Specimen Collection; Female; Hu

1998
Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.
    The Journal of rheumatology, 1999, Volume: 26, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In

1999
Multiple-dose pharmacokinetics of rectally administered acetaminophen in term infants.
    Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:5

    Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Chromatography, High Pressure Liqui

1999
Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study.
    Journal of clinical pharmacology, 2000, Volume: 40, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics, Non-Narcotic; Double-Blind Method; Dry Sock

2000
Combined analgesia and local anesthesia to minimize pain during circumcision.
    Archives of pediatrics & adolescent medicine, 2000, Volume: 154, Issue:6

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Anesthesia, Local; Anesthe

2000
Randomized double blind trial of an ayurvedic plant derived formulation for treatment of rheumatoid arthritis.
    The Journal of rheumatology, 2000, Volume: 27, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans;

2000
Managing delayed-onset muscle soreness: lack of effect of selected oral systemic analgesics.
    Archives of physical medicine and rehabilitation, 2000, Volume: 81, Issue:7

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Codeine; Double-

2000
Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain.
    Clinical therapeutics, 2000, Volume: 22, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics; Chronic Disease; Codeine; Double-Blind Method; Drug Therapy,

2000
A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arm Injuries; Diclofenac; Emergency Se

2000
Effects of rectally administered paracetamol on infants delivered by vacuum extraction.
    European journal of obstetrics, gynecology, and reproductive biology, 2001, Volume: 94, Issue:1

    Topics: Acetaminophen; Administration, Rectal; Double-Blind Method; Facial Expression; Female; Humans; Infan

2001
Disodium clodronate in painful nonresponsive periarthropathy of the hip.
    International journal of tissue reactions, 2000, Volume: 22, Issue:4

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Bone Resorption; Bursitis; Clodronic Acid; Drug Thera

2000
Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.
    The Journal of rheumatology, 2001, Volume: 28, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroid

2001
[Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol].
    Presse medicale (Paris, France : 1983), 2001, May-19, Volume: 30, Issue:18

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female;

2001
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial.
    Clinical therapeutics, 2001, Volume: 23, Issue:9

    Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics; Analgesics, Opioid; Codeine; Double-Bl

2001
Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2001, Oct-30, Volume: 165, Issue:9

    Topics: Acetaminophen; Adult; Analgesics; Codeine; Delivery, Obstetric; Double-Blind Method; Episiotomy; Fem

2001
Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial.
    International journal of clinical pharmacology research, 2001, Volume: 21, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Butylscopolammonium Bromide; Clonixin; Cross-Over St

2001
Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study.
    Clinical therapeutics, 2002, Volume: 24, Issue:2

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Respon

2002
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 3, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri

1976
[New preparation with antalgic sedative and anxiolytic activity in manifestations of interest to internal medicine. Double-blind controlled clinical study].
    Minerva medica, 1977, Feb-21, Volume: 68, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Clor

1977
Acetaminophen.
    Annals of internal medicine, 1977, Volume: 87, Issue:2

    Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic;

1977
Mefenamic acid and dextropropoxyphene with paracetamol as analgesics in the accident department.
    Current medical research and opinion, 1977, Volume: 5, Issue:2

    Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug

1977
Effect of acetylsalicylic acid, paracetamol, and placebo on pain and blood loss in dysmenorrhoeic women.
    European journal of clinical pharmacology, 1978, Dec-18, Volume: 14, Issue:6

    Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female;

1978
Evaluation of acetaminophen, propoxyphene, and their combination in office practice.
    Journal of clinical pharmacology, 1979, Volume: 19, Issue:4

    Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Dextropropoxyphene; Drug Combinations; Family

1979
Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain. A double blind study.
    International journal of clinical pharmacology and biopharmacy, 1979, Volume: 17, Issue:6

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Electric Stimulation; Fem

1979
[Treatment of distortions and non-traumatic conditions of pain and swelling. Double-blind trial with an analgetic and detumescent drug combination].
    Fortschritte der Medizin, 1978, May-18, Volume: 96, Issue:19

    Topics: Acetaminophen; Adult; Double-Blind Method; Drug Combinations; Drug Synergism; Edema; Humans; Joint D

1978
A controlled study of diflunisal in sprains and strains.
    Current medical research and opinion, 1978, Volume: 5, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics; Biphenyl Compounds; Dextropropoxyph

1978
Drug therapy. Acetaminophen.
    The New England journal of medicine, 1976, Dec-02, Volume: 295, Issue:23

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Body Temperature; Chemical and Drug Induced Liver Injury;

1976
Azapropazone compared with indomethacin in the treatment of rheumatoid arthritis.
    The Practitioner, 1976, Volume: 217, Issue:1301

    Topics: Acetaminophen; Adult; Aged; Apazone; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Hand;

1976
The efficacy of Percogesic in relief of musculoskeletal pain associated with anxiety.
    Psychosomatics, 1976, Volume: 17, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Drug Combinations; Female

1976
A clinical Trial of Tofranil in osteo-arthritis.
    The Journal of international medical research, 1976, Volume: 4, Issue:2 Suppl

    Topics: Acetaminophen; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Imipram

1976
A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice.
    The Journal of international medical research, 1976, Volume: 4, Issue:3

    Topics: Acetaminophen; Analgesics; Aspirin; Clinical Trials as Topic; Female; Humans; Hydrocodone; Male; ort

1976
Acetaminophen extra strength capsules versus propoxphene compound-65 versus placebo: a double-blind study of effectiveness and safety.
    Current therapeutic research, clinical and experimental, 1975, Volume: 17, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Capsules; Clinical Trials as Topic; Dextropropo

1975
Paracetamol/codeine in relieving pain following removal of impacted mandibular third molars.
    International journal of oral surgery, 1975, Volume: 4, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Codeine; Drug Therapy, Combination; Edema; Female; Humans

1975
A comparative study of Parafon Forte tablets and soma compound in the treatment of painful skeletal muscle conditions.
    Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Benzoxazoles; Carisoprodol; Chlorzoxazone; Drug Combinations; Fema

1976
Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance.
    Annals of the rheumatic diseases, 1975, Volume: 34, Issue:2

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Digestive System; Female; F

1975
[Comparative evaluation of the therapeutic efficiency of flurbiprofene in rheumatoid polyarthritis].
    Revue du rhumatisme et des maladies osteo-articulaires, 1975, Volume: 42, Issue:6

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Biphenyl Compounds; Chemical Phenomena; Chemistry; Cl

1975
Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity.
    Pain, 1992, Volume: 50, Issue:2

    Topics: Acetaminophen; Adult; Antipyrine; Double-Blind Method; Electroencephalography; Evoked Potentials, Au

1992
What do women want during medical abortion?
    Contraception, 1992, Volume: 46, Issue:5

    Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Administration, Oral; Adolesce

1992
The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips.
    Current medical research and opinion, 1992, Volume: 13, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chronic Disease; Codeine; Delayed-Action Preparations

1992
Evaluation of the analgesic efficacy of a combination of naproxen and paracetamol versus dipyrone on the tourniquet test in healthy volunteers.
    Proceedings of the Western Pharmacology Society, 1992, Volume: 35

    Topics: Acetaminophen; Adult; Autonomic Nervous System; Dipyrone; Double-Blind Method; Drug Combinations; El

1992
Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol. Double blind, placebo-controlled evaluation using painful laser stimulation.
    European journal of clinical pharmacology, 1992, Volume: 42, Issue:3

    Topics: Acetaminophen; Adult; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Lasers; Male

1992
Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories.
    Drugs under experimental and clinical research, 1992, Volume: 18, Issue:2

    Topics: Acetaminophen; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschoo

1992
Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol.
    European journal of clinical pharmacology, 1991, Volume: 40, Issue:6

    Topics: Acetaminophen; Double-Blind Method; Episiotomy; Female; Humans; Naproxen; Norway; Pain; Pain Measure

1991
Hydrocodone versus codeine in acute musculoskeletal pain.
    Annals of emergency medicine, 1991, Volume: 20, Issue:10

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Codeine; Double-Blind Method; Drug Combinatio

1991
Randomized, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children.
    The Journal of pediatrics, 1991, Volume: 119, Issue:5

    Topics: Acetaminophen; Administration, Oral; Child; Deglutition; Double-Blind Method; Drug Tolerance; Female

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
A comparison of the hypoalgesic effect of paracetamol in slow-release and plain tablets on laser-induced pain.
    British journal of clinical pharmacology, 1991, Volume: 31, Issue:3

    Topics: Acetaminophen; Adult; Analgesics; Delayed-Action Preparations; Double-Blind Method; Female; Humans;

1991
Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine--a quantitative evaluation by laser induced pain.
    European journal of clinical pharmacology, 1991, Volume: 40, Issue:3

    Topics: Acetaminophen; Adult; Analgesia; Brain; Codeine; Double-Blind Method; Humans; Lasers; Membrane Poten

1991
Acetaminophen as a pain enhancer during voluntary interruption of pregnancy with mifepristone and sulprostone.
    European journal of clinical pharmacology, 1990, Volume: 39, Issue:6

    Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Dinoprostone; Double-Blind Met

1990
A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:1

    Topics: Acetaminophen; Administration, Topical; Adult; Ankle; Ankle Injuries; Anti-Inflammatory Agents, Non-

1990
Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study.
    Pain, 1990, Volume: 43, Issue:3

    Topics: Acetaminophen; Aged; Chronic Disease; Codeine; Double-Blind Method; Drug Combinations; Hip Joint; Hu

1990
Evaluation of analgesic agents in recurring headache compared with other clinical pain models.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Codeine; Data Interpretation, Statistical; Doubl

1990
Analgesic efficacy of acetaminophen sustained release.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:7

    Topics: Acetaminophen; Adult; Ambulatory Care; Analgesia; Delayed-Action Preparations; Double-Blind Method;

1990
The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain.
    Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:6

    Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Bone Neoplasms; Chronic Disease; Codeine; Double-B

1988
Joint pain and quality of life; results of a randomised trial.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:2

    Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Dextropropoxyphen

1989
Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen.
    Southern medical journal, 1987, Volume: 80, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Arthroscopy; Clinical Trials as Topic; Dextropropoxyphene; Double-

1987
Comparative study of high bio-availability glaphenine and paracetamol in cervical and lumbar arthrosis.
    Clinical rheumatology, 1987, Volume: 6, Issue:4

    Topics: Acetaminophen; Arthritis; Biological Availability; Double-Blind Method; Glafenine; Humans; Movement;

1987
A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach.
    Clinical rheumatology, 1988, Volume: 7, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Double-Blind Method; Glafenine; Hip Joint; Humans; Kn

1988
Flurbiprofen for the treatment of soft tissue trauma.
    The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A

    Topics: Acetaminophen; Aspirin; Back Pain; Flurbiprofen; Humans; Knee; Leg Injuries; Ligaments, Articular; P

1986
Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine.
    The Journal of family practice, 1986, Volume: 23, Issue:2

    Topics: Acetaminophen; Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Codeine; Diflunisal; Drug

1986
Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion.
    American journal of obstetrics and gynecology, 1986, Volume: 155, Issue:3

    Topics: Acetaminophen; Adult; Back Pain; Clinical Trials as Topic; Colic; Electrocoagulation; Female; Humans

1986
The pain intensity at analgesic intake, and the efficacy of diflunisal in single doses and effervescent acetaminophen in single and repeated doses.
    Pharmacotherapy, 1988, Volume: 8, Issue:3

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Pain; Salicylates;

1988
Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain.
    Clinical therapeutics, 1986, Volume: 8, Issue:5

    Topics: Acetaminophen; Adult; Ankle Injuries; Codeine; Diflunisal; Drug Combinations; Edema; Female; Humans;

1986
Sore throat pain in the evaluation of mild analgesics.
    Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:6

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Double-Blind Method; Drug Evaluation; Fem

1988
Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine.
    The Pediatric infectious disease journal, 1987, Volume: 6, Issue:8

    Topics: Acetaminophen; Body Temperature; Clinical Trials as Topic; Diphtheria Toxoid; Diphtheria-Tetanus-Per

1987
[Combined analgesics in myalgia of the neck. A double-blind comparison of paracetamol and orphenadrine (Norgesic) and paracetamol and codeine (Paralgin forte) in general practice].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1986, Jan-20, Volume: 106, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double

1986
Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains.
    Clinical therapeutics, 1986, Volume: 8, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Athletic Injuries; Clinical Trials as Topic; Codeine; Diflunisal;

1986
Comparison of the analgesic effect of a corticosteroid and paracetamol in patients with pain after oral surgery.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:4

    Topics: Acetaminophen; Adolescent; Adrenal Cortex Hormones; Adult; Analgesics; Clinical Trials as Topic; Dou

1986
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
    The American journal of emergency medicine, 1987, Volume: 5, Issue:1

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele

1987
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
    The American journal of emergency medicine, 1987, Volume: 5, Issue:1

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele

1987
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
    The American journal of emergency medicine, 1987, Volume: 5, Issue:1

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele

1987
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
    The American journal of emergency medicine, 1987, Volume: 5, Issue:1

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele

1987
Efficacy of diflunisal versus acetaminophen with codeine in controlling mild to moderate pain after arthroscopy.
    Clinical therapeutics, 1986, Volume: 8, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Arthroscopy; Codeine; Diflunisal; Drug Combinations; Drug Evaluati

1986
Double-blind comparison of ketoprofen and placebo in the treatment of sprains and strains.
    Clinical therapeutics, 1986, Volume: 8, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Cryotherapy; Double-Blind Method; Female; Humans; Immobilization;

1986
Oral meptazinol--United Kingdom experience.
    Postgraduate medical journal, 1985, Volume: 61 Suppl 2

    Topics: Acetaminophen; Adult; Aged; Azepines; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Met

1985
A comparative study of Propain and a dextropropoxyphene/paracetamol combination analgesic.
    The British journal of clinical practice, 1985, Volume: 39, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Dextropropoxyphene; Diphenhydramine; Drug

1985
Effect of an analgesic drug (paralgin forte) upon laboratory pain under different cognitive manipulations: an experimental study.
    Acta neurologica Scandinavica, 1985, Volume: 72, Issue:1

    Topics: Acetaminophen; Adult; Analgesics; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; M

1985
Use of subjective responses to evaluate efficacy of mild analgesic-sedative combinations.
    Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics; Chloral Hydrate; Clinical Trials as Topic; Drug Therapy, Combination; Fem

1974
A double-blind comparative trial of 'parazolidin' and paracetamol.
    The British journal of clinical practice, 1969, Volume: 23, Issue:11

    Topics: Acetaminophen; Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Elbow Joint; Female; Fi

1969
Parazolidin: a new compound analgesic preparation.
    The Journal of the College of General Practitioners, 1966, Volume: 11, Issue:4

    Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Muscular Di

1966
Simple analgesics for arthritis.
    British medical journal, 1974, Oct-26, Volume: 4, Issue:5938

    Topics: Acetaminophen; Alkenes; Analgesics; Arthritis, Rheumatoid; Aspirin; Codeine; Color; Dextropropoxyphe

1974
Fenoprofen in the treatment of osteoarthrosis.
    Current medical research and opinion, 1974, Volume: 2, Issue:9

    Topics: Acetaminophen; Anti-Inflammatory Agents; Humans; Osteoarthritis; Pain; Phenyl Ethers; Phenylbutazone

1974
Acetaminophen versus propoxyphene hydrochloride for relief of pain in episiotomy patients.
    Journal of clinical pharmacology, 1973, Volume: 13, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Clinical Trials as Topic; Dextropropoxyphene; Episiotomy; Female;

1973
[EMA 3--a phenacetin-free combination with analgesic action].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jun-12, Volume: 62, Issue:24

    Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as

1973
Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis.
    British medical journal, 1973, Oct-13, Volume: 4, Issue:5884

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzoates;

1973
Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.
    British medical journal, 1974, Feb-02, Volume: 1, Issue:5900

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Body Temperature; Clinical Trials as Topic; Deafness;

1974
Double-blind cross-over comparison of indomethacin, flurbiprofen, and placebo in ankylosing spondylitis.
    Annals of the rheumatic diseases, 1974, Volume: 33, Issue:2

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents; Biphenyl Compounds; Blood Sedimentation; Clinical Tr

1974
Mild analgesics evaluated with the "Submaximum Effort Tourniquet Technique". II. The influence of a tranquilizer on their effect.
    Psychopharmacologia, 1974, Volume: 38, Issue:4

    Topics: Acetaminophen; Adult; Alkenes; Analgesics; Analysis of Variance; Anthracenes; Clinical Trials as Top

1974
A double-blind evaluation of Parafon Forte in the treatment of musculo-skeletal back conditions.
    Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Back; Benzoxazoles; Bone Diseases; Chlorzoxazone; Clinical Trials

1972
Thrombosis in sickle-cell pain crises? Controlled trial of ancrod (Arvin) in young adults.
    The Journal of tropical medicine and hygiene, 1973, Volume: 76, Issue:11

    Topics: Acetaminophen; Adolescent; Adult; Ampicillin; Anemia, Sickle Cell; Child; Chloroquine; Female; Fetal

1973
Perceptual style and pain tolerance. II. The influence of an anxiolytic agent.
    Journal of psychosomatic research, 1973, Volume: 17, Issue:5

    Topics: Acetaminophen; Adaptation, Physiological; Adaptation, Psychological; Adult; Anthracenes; Anxiety; Fe

1973
Dialog. A double-blind clinical study of dialog, darvon and a placebo in the management of postoperative dental pain.
    Journal of oral therapeutics and pharmacology, 1967, Volume: 4, Issue:2

    Topics: Acetaminophen; Barbiturates; Clinical Trials as Topic; Pain; Postoperative Care; Surgery, Oral; Toot

1967
[Clinical observation on the analgesic effect of the acetaminophen-phenylbutazone combination in angiology].
    Hospital (Rio de Janeiro, Brazil), 1968, Volume: 73, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Arteriosclerosis; Arteriovenous Fistula; Blood V

1968
Dialog in treatment of dental pain.
    Oral surgery, oral medicine, and oral pathology, 1969, Volume: 28, Issue:2

    Topics: Acetaminophen; Adult; Barbiturates; Clinical Trials as Topic; Female; Humans; Male; Pain; Postoperat

1969
Evaluation of mefenamic acid and flufenamic acid in clinical pain.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Acetaminophen; Anti-Inflammatory Agents; Clinical Trials as Topic; Flufenamic Acid; Fluorine; Humans

1966
Mefenamic acid as an analgesic.
    The Practitioner, 1970, Volume: 204, Issue:224

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Drug Syn

1970
Method, design, and analysis of a comparative study of analgetics.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 3, Issue:4

    Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P

1970
A comparison of analgesic therapies for the relief of acute otalgia.
    The British journal of clinical practice, 1970, Volume: 24, Issue:11

    Topics: Acetaminophen; Choline; Clinical Trials as Topic; Ear Diseases; Humans; Pain; Salicylates

1970
Method, design, and analysis of a comparative study of analgetics.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 4, Issue:4

    Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P

1970
[Experiences with an analgesic in accident surgery].
    Die Medizinische Welt, 1965, Jun-12, Volume: 24

    Topics: Acetaminophen; Clinical Trials as Topic; Humans; Pain; Wounds and Injuries

1965
A clinical comparison of Panadeine Co., soluble codeine co., soluble aspirin in the relief of pain.
    The British journal of clinical practice, 1966, Volume: 20, Issue:10

    Topics: Acetaminophen; Aspirin; Clinical Trials as Topic; Codeine; Humans; Pain

1966
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
    The Medical journal of Australia, 1970, Aug-15, Volume: 2, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei

1970

Other Studies

576 other studies available for acetaminophen and Ache

ArticleYear
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Fever; Humans; Intramolecular Oxi

2008
Antinociceptive properties of caffeic acid derivatives in mice.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Analgesics; Animals; Caffeic Acids; Mice; Molecular Structure; Pain; Structure-Activity Relationship

2009
Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents.
    European journal of medicinal chemistry, 2014, Jul-23, Volume: 82

    Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Dose-Response Relationship, Drug;

2014
Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Acetaminophen; Amidohydrolases; Aminophenols; Analgesics; Animals; Antipyretics; Arachidonic Acids;

2021
[Pain and dementia: what to consider?]
    Deutsche medizinische Wochenschrift (1946), 2021, Volume: 146, Issue:19

    Topics: Acetaminophen; Cognition; Dementia; Humans; Pain; Pain Management

2021
Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis.
    Journal of clinical gastroenterology, 2023, Jan-01, Volume: 57, Issue:1

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

2023
Pharmacological Pain Treatment in 2012 and 2017 Among Older People with Major Neurocognitive Disorder.
    Drugs & aging, 2021, Volume: 38, Issue:11

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No

2021
Single-Dose Oral NSAIDs and Acetaminophen for Perineal Pain in the Early Postpartum Period.
    American family physician, 2021, 12-01, Volume: 104, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Pa

2021
Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain.
    Fundamental & clinical pharmacology, 2022, Volume: 36, Issue:3

    Topics: Acetaminophen; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Meloxicam; Mice; Pain; R

2022
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
    Behavioural pharmacology, 2022, 02-01, Volume: 33, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr

2022
Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers.
    European journal of drug metabolism and pharmacokinetics, 2022, Volume: 47, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adult; Biological Availability; Body Composition; Body Weight;

2022
Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study.
    Journal of long-term effects of medical implants, 2022, Volume: 32, Issue:1

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Humans; Pain; Retrospective Studies

2022
Child Emotion Regulation Capacity Moderates the Association Between Parent Behaviors and Child Distress During Pediatric Venipuncture.
    Journal of pediatric psychology, 2023, 02-21, Volume: 48, Issue:2

    Topics: Acetaminophen; Adult; Child; Emotional Regulation; Humans; Needles; Pain; Parents; Phlebotomy

2023
Use of Intravenous Paracetamol Preoperatively Favors Lower Risk of Delirium and Functional Recovery in Elderly Patients with Hip Fracture: A Propensity Score-Matched Analysis.
    Pain research & management, 2022, Volume: 2022

    Topics: Acetaminophen; Aged; Delirium; Hip Fractures; Humans; Pain; Propensity Score; Retrospective Studies

2022
Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study.
    Headache, 2022, Volume: 62, Issue:6

    Topics: Acetaminophen; Caffeine; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nonprescri

2022
Immediate full weight bearing after pelvic percutaneous fixation by screw for simple acetabular and pelvic ring fractures in patients older than sixty five years.
    International orthopaedics, 2022, Volume: 46, Issue:10

    Topics: Acetaminophen; Bone Screws; Fractures, Bone; Humans; Morphine; Pain; Retrospective Studies; Weight-B

2022
Patient satisfaction after distal upper limb surgery under WALANT versus axillary block: A propensity-matched comparative cohort study.
    Hand surgery & rehabilitation, 2022, Volume: 41, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Cohort Studies; Humans; Ketoprofen; Pain; Patient Sat

2022
Translator use not associated with longer time to pain medication in initial evaluation of low-severity geriatric trauma.
    The American journal of emergency medicine, 2022, Volume: 60

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Female; Humans; Lidocaine; Male; Pain; Retrospective Studie

2022
Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort.
    Urology, 2022, Volume: 168

    Topics: Acetaminophen; Analgesics, Opioid; Bupivacaine; Humans; Ketorolac; Male; Pain; Prostatectomy; Roboti

2022
A paediatric pain assessment and management survey at Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2022, 08-02, Volume: 112, Issue:8

    Topics: Acetaminophen; Child; Cross-Sectional Studies; Female; Hospitals; Humans; Infant; Infant, Newborn; M

2022
Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.
    Behavioural pharmacology, 2022, 12-01, Volume: 33, Issue:8

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Feeding Beh

2022
Pediatric Hip Disease Increases the Risk for Opioid Use in Adulthood: Long-term Burden of Pain and Depression.
    Pain physician, 2022, Volume: 25, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents; Antidepressive Agent

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
    Environmental science & technology, 2022, 12-06, Volume: 56, Issue:23

    Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans

2022
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
    Substance use & misuse, 2023, Volume: 58, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri

2023
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
    Substance use & misuse, 2023, Volume: 58, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri

2023
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
    Substance use & misuse, 2023, Volume: 58, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri

2023
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
    Substance use & misuse, 2023, Volume: 58, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri

2023
Prevalence and persistent prescription of analgesic drugs in persons admitted with dementia to a nursing home - A longitudinal study.
    PloS one, 2022, Volume: 17, Issue:12

    Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Analgesics; Analgesics, Opioid; Dement

2022
Modulation of inflammatory mediators involved in the antinociceptive and anti-inflammatory effects of a new thioamide derivative: thiocyanoacetamide.
    Inflammopharmacology, 2023, Volume: 31, Issue:2

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Inflammation Mediators; Pain; Rats

2023
Use of analgesics in Denmark: A national survey.
    Basic & clinical pharmacology & toxicology, 2023, Volume: 132, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Denmark; Drug-Related Side Effects and Adverse Reactio

2023
A Descriptive Study of Treatment of Pain in Acute Care for Patients Living With Dementia.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2023, Volume: 24, Issue:3

    Topics: Acetaminophen; Dementia; Female; Humans; Pain; Pain Management; Tramadol

2023
Impact of dexmedetomidine in conjunction with a weaning protocol on post-surgical opioid use in a neonatal intensive care unit.
    Pharmacotherapy, 2023, Volume: 43, Issue:7

    Topics: Acetaminophen; Analgesics, Opioid; Clonidine; Dexmedetomidine; Humans; Infant, Newborn; Intensive Ca

2023
Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study.
    International journal of clinical oncology, 2023, Volume: 28, Issue:9

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age

2023
Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:11

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Bilirubin; Cohort Studies; Humans; In

2023
MANAGING ARTHRITIS PAIN: MEDICATIONS AND LIFESTYLE CHANGES.
    Georgian medical news, 2023, Issue:339

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Life Style; Osteoarthritis, Knee; Pa

2023
The Perioperative Pain Management Bundle is Feasible: Findings From the PAIN OUT Registry.
    The Clinical journal of pain, 2023, 10-01, Volume: 39, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Pain; Pain Management; Registries

2023
Mpox Pain Management with Topical Agents: A Case Series.
    Journal of pain & palliative care pharmacotherapy, 2023, Volume: 37, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Lidocaine; Mpox (monkeypox); Pain; P

2023
Fixing a Broken Heart Opens the Door to Developing K
    The Journal of pharmacology and experimental therapeutics, 2023, Volume: 387, Issue:1

    Topics: Acetaminophen; Adenosine Triphosphate; Analgesics; Humans; Pain

2023
Blot Clot Risk Higher When Pain Relievers Used With Hormonal Contraception.
    JAMA, 2023, 10-10, Volume: 330, Issue:14

    Topics: Acetaminophen; Analgesics; Contraception; Contraceptives, Oral, Hormonal; Female; Hormonal Contracep

2023
[Clinical characteristics and therapeutic effectiveness of post craniotomy cervicogenic headache].
    Zhonghua yi xue za zhi, 2023, Oct-10, Volume: 103, Issue:37

    Topics: Acetaminophen; Craniotomy; Humans; Oxycodone; Pain; Post-Traumatic Headache; Retrospective Studies

2023
Pain and quality of life in nursing home residents with dementia after admission - a longitudinal study.
    BMC health services research, 2023, Sep-27, Volume: 23, Issue:1

    Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Analgesics, Opioid; Dementia; Female;

2023
Safety and efficacy of non-standard posology of paracetamol to manage pain in pediatric patients.
    Pharmacological research, 2023, Volume: 197

    Topics: Acetaminophen; Child; Humans; Pain

2023
Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study.
    Journal of medical Internet research, 2023, 11-14, Volume: 25

    Topics: Acetaminophen; Codeine; Humans; Machine Learning; Pain; Social Media; Tramadol

2023
Studies on solubility measurement of codeine phosphate (pain reliever drug) in supercritical carbon dioxide and modeling.
    Scientific reports, 2023, Nov-29, Volume: 13, Issue:1

    Topics: Acetaminophen; Carbon Dioxide; Codeine; Humans; Pain; Solubility; Temperature

2023
Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients.
    The Journal of the American Academy of Orthopaedic Surgeons, 2020, Apr-15, Volume: 28, Issue:8

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Delirium; Female; Hip Fractures; Humans;

2020
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
    Drug research, 2019, Volume: 69, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase

2019
Towards an Effective and Safe Treatment of Inflammatory Pain: A Delphi-Guided Expert Consensus.
    Advances in therapy, 2019, Volume: 36, Issue:10

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Consensus; Health Knowledge, Att

2019
Operating without opioids.
    Nature, 2019, Volume: 573, Issue:7773

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Celecoxib; Drug Combinations; Drug Prescriptions; Gen

2019
Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol.
    BMJ open, 2019, Oct-14, Volume: 9, Issue:10

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Australia; Child; Child, Preschool; Chron

2019
Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort.
    Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Arthritis; Behavioral Symptoms; Cohort Studies; Dose

2020
Analgesic use at ovulation and implantation and human fertility.
    American journal of obstetrics and gynecology, 2020, Volume: 222, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Embryo Implantat

2020
Central nervous system evaluation of an ethanol extract of Bidens odorata Cav (Asteraceae) leaves, and its antinociceptive interaction with paracetamol and naproxen.
    Inflammopharmacology, 2020, Volume: 28, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Ast

2020
Osteoarthritis in Older Adults: Nonsteroidal Anti-Inflammatory Drugs Versus Opioids.
    The Senior care pharmacist, 2019, Dec-01, Volume: 34, Issue:10

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2019
Pain Patterns and Treatment Among Nursing Home Residents With Moderate-Severe Cognitive Impairment.
    Journal of the American Geriatrics Society, 2020, Volume: 68, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2020
Paracetamol for pain in adults.
    BMJ (Clinical research ed.), 2019, Dec-31, Volume: 367

    Topics: Acetaminophen; Drug Overdose; Humans; Osteoarthritis, Knee; Pain; Practice Guidelines as Topic

2019
Reply.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020, Volume: 18, Issue:8

    Topics: Acetaminophen; Humans; Pain

2020
Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception.
    Psychopharmacology, 2020, Volume: 237, Issue:5

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dibenz

2020
Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats.
    Inflammopharmacology, 2020, Volume: 28, Issue:6

    Topics: Acetaminophen; Analgesics; Animals; Codeine; Drug Combinations; Male; Morphine; Paclitaxel; Pain; Ra

2020
Pain Management in a Patient with Kidney Failure.
    Clinical journal of the American Society of Nephrology : CJASN, 2020, 11-06, Volume: 15, Issue:11

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2020
Pain Management for Pediatric Burns in the Outpatient Setting: A Changing Paradigm?
    Journal of burn care & research : official publication of the American Burn Association, 2020, 07-03, Volume: 41, Issue:4

    Topics: Acetaminophen; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla

2020
Letter to the Editor Regarding "Intravenous Acetaminophen (Paracetamol) for Post-Craniotomy Pain; Systematic Review and Meta-Analysis of Randomized Clinical Trials".
    World neurosurgery, 2020, Volume: 137

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Craniotomy; Humans; Pain; Randomized Controlled Trials as T

2020
The effect of intraoperative intravenous acetaminophen on intraoperative and postoperative opioid use and pain scores in minimally invasive spine surgery.
    Journal of clinical anesthesia, 2020, Volume: 65

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Pa

2020
Exploration of self-medication practice in Pokhara valley of Nepal.
    BMC public health, 2020, May-19, Volume: 20, Issue:1

    Topics: Acetaminophen; Adult; Analgesics; Anti-Bacterial Agents; Common Cold; Cough; Cross-Sectional Studies

2020
Pain during medical abortion in early pregnancy in teenage and adult women.
    Acta obstetricia et gynecologica Scandinavica, 2020, Volume: 99, Issue:12

    Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Adolescent; Adult; Analgesics;

2020
Association Between Male Use of Pain Medication and Fecundability.
    American journal of epidemiology, 2020, 11-02, Volume: 189, Issue:11

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Rate; Cohort Studies;

2020
A COVID-19 patient with intense burning pain.
    Journal of neurovirology, 2020, Volume: 26, Issue:5

    Topics: Acetaminophen; Analgesics; Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome; Back Pain;

2020
In Reply to the Letter to the Editor Regarding "Intravenous Acetaminophen (Paracetamol) for Postcraniotomy Pain; Systematic Review and Meta-analysis of Randomized Clinical Trials".
    World neurosurgery, 2020, Volume: 140

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Humans; Pain; Randomized Contr

2020
Pain management modalities for hidradenitis suppurativa: a patient survey.
    The Journal of dermatological treatment, 2022, Volume: 33, Issue:3

    Topics: Acetaminophen; Female; Hidradenitis Suppurativa; Humans; Male; Pain; Pain Management; Severity of Il

2022
Intravenous paracetamol for neonates: long-term diseases not escalated during 5 years of follow-up.
    Archives of disease in childhood. Fetal and neonatal edition, 2021, Volume: 106, Issue:2

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Apgar Score; Asthma; Birth Wei

2021
Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
    BMC nephrology, 2020, 09-18, Volume: 21, Issue:1

    Topics: Acetaminophen; Advance Care Planning; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesic

2020
The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2021, Volume: 17, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Gene

2021
Overcoming the paracetamol dose challenge with wrinkled mesoporous carbon spheres.
    Journal of colloid and interface science, 2021, Mar-15, Volume: 586

    Topics: Acetaminophen; Carbon; COVID-19 Drug Treatment; Delayed-Action Preparations; Drug Carriers; Humans;

2021
In acute soft tissue injuries, NSAIDs do not differ from acetaminophen for pain reduction.
    Annals of internal medicine, 2020, 12-15, Volume: 173, Issue:12

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain; Pharmaceutical Pre

2020
Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence?
    BMC pregnancy and childbirth, 2021, Jan-06, Volume: 21, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Causality; Cohort Studies; Female; Gestational Age; Headach

2021
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test.
    BMC pharmacology & toxicology, 2021, 01-07, Volume: 22, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Comb

2021
Evaluation of painkillers according to the principles of rational drug use in patients registered to a family medicine unit.
    International journal of clinical practice, 2021, Volume: 75, Issue:5

    Topics: Acetaminophen; Analgesics; Family Practice; Female; Humans; Pain; Pharmaceutical Preparations

2021
Pain and pain management the first two weeks after trauma.
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2021, 02-02, Volume: 141, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain; Pai

2021
Paracetamol or ibuprofen for fever or pain in children under 2 years old.
    Journal of paediatrics and child health, 2021, Volume: 57, Issue:8

    Topics: Acetaminophen; Antipyretics; Child; Fever; Humans; Ibuprofen; Infant; Pain

2021
Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials.
    eLife, 2021, 04-13, Volume: 10

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Blood Specimen Collection; Brain; Clinical Tri

2021
In vitro and In vivo Synergistic Interactions of the Flavonoid Rutin with Paracetamol and with Non-Steroidal Anti-Inflammatory Drugs.
    Archives of medical research, 2021, Volume: 52, Issue:6

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Drug Synergism;

2021
Intravenous Acetaminophen vs Intravenous Diclofenac in the Management of Painful Crisis in Sickle Cell Disease: Authors' Reply.
    Indian pediatrics, 2021, 05-15, Volume: 58, Issue:5

    Topics: Acetaminophen; Administration, Intravenous; Anemia, Sickle Cell; Diclofenac; Humans; Pain

2021
Intravenous Acetaminophen vs Intravenous Diclofenac in the Management of Painful Crisis in Sickle Cell Disease.
    Indian pediatrics, 2021, 05-15, Volume: 58, Issue:5

    Topics: Acetaminophen; Administration, Intravenous; Anemia, Sickle Cell; Diclofenac; Humans; Pain

2021
Tramadol oral solution (Qdolo) for pain.
    The Medical letter on drugs and therapeutics, 2021, 05-31, Volume: 63, Issue:1625

    Topics: Acetaminophen; Administration, Oral; Analgesics, Opioid; Child; Cytochrome P-450 CYP2D6; Female; Hum

2021
Pain in nursing home residents with dementia and its association to quality of life.
    Aging & mental health, 2022, Volume: 26, Issue:9

    Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Cross-Sectional Studies; Dementia; Fem

2022
COVID-19'da İhmal Edilen Semptom: Ağrı.
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2021, Volume: 33, Issue:3

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; COVID-19; Humans;

2021
Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes.
    Rheumatology (Oxford, England), 2022, 04-11, Volume: 61, Issue:4

    Topics: Acetaminophen; Autoimmune Diseases; Cohort Studies; Female; Humans; Infant, Newborn; Pain; Pre-Eclam

2022
Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology.
    BMJ case reports, 2021, Aug-03, Volume: 14, Issue:8

    Topics: Acetaminophen; Aged, 80 and over; Codeine; Drug Eruptions; Humans; Male; Nonprescription Drugs; Pain

2021
Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis.
    BMJ open, 2021, 08-11, Volume: 11, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Meta-Analysis as Topic; Osteoarthrit

2021
Nonsteroidal Anti-inflammatory Drugs Alone or in Combination With Acetaminophen are Effective and Safe Treatments for Short-Term Pain Control in Nonsurgical Endodontic Treatment.
    The journal of evidence-based dental practice, 2021, Volume: 21, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain; Pain Management; Pharmaceutica

2021
Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care.
    Current medical research and opinion, 2017, Volume: 33, Issue:6

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Coh

2017
Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn.
    Anesthesiology, 2017, Volume: 127, Issue:2

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Male; Nerve Fib

2017
What is the dose of intravenous paracetamol for pain relief in neonates?
    Archives of disease in childhood, 2017, Volume: 102, Issue:7

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Dose-Response Relationship, Dr

2017
In Response: The Contribution of the Emergency Department to Opioid Pain Reliever Misuse and Diversion: A Critical Review.
    Pain practice : the official journal of World Institute of Pain, 2017, Volume: 17, Issue:8

    Topics: Acetaminophen; Analgesics, Opioid; Emergency Service, Hospital; Humans; Opioid-Related Disorders; Pa

2017
Pain in Children With Cancer: Prevalence, Characteristics, and Parent Management.
    The Clinical journal of pain, 2018, Volume: 34, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Caregivers; Child; Female; Humans; Male; Middle Aged

2018
In Patients Having Hip or Knee Arthroplasty, Intravenous and Oral Acetaminophen Did Not Differ for 24-Hour Pain or Narcotic Use.
    The Journal of bone and joint surgery. American volume, 2017, 08-16, Volume: 99, Issue:16

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Humans; Narcotics; Pain; P

2017
Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.
    Behavioural brain research, 2018, Jan-30, Volume: 337

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Diseas

2018
Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin.
    Scientific reports, 2017, 09-29, Volume: 7, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Diterpenes; Gene Expression; Hyp

2017
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.
    Scientific reports, 2017, 10-06, Volume: 7, Issue:1

    Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Capsaicin; Cell Death; Cysteine; Ganglia, Spinal; HE

2017
Response to Letter to the Editor The Contribution of the Emergency Department to Opioid Pain Reliever Misuse and Diversion: A Critical Review.
    Pain practice : the official journal of World Institute of Pain, 2017, Volume: 17, Issue:8

    Topics: Acetaminophen; Analgesics, Opioid; Emergency Service, Hospital; Humans; Opioid-Related Disorders; Pa

2017
Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort.
    EBioMedicine, 2017, Volume: 26

    Topics: Acetaminophen; Adult; Analgesics; Dose-Response Relationship, Drug; Female; Fetal Blood; Gestational

2017
Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study.
    BMC research notes, 2017, Dec-04, Volume: 10, Issue:1

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Critical Illness; Cro

2017
Expectations about the effectiveness of pain- and itch-relieving medication administered via different routes.
    European journal of pain (London, England), 2018, Volume: 22, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Cross-Sectional Studies; Drug Administration Routes; Female;

2018
Analyzing Analgesic Medications in Community-Dwelling Older Adults.
    Pain medicine (Malden, Mass.), 2019, 01-01, Volume: 20, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opi

2019
Use of analgesics in France, following dextropropoxyphene withdrawal.
    BMC health services research, 2018, 04-02, Volume: 18, Issue:1

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Codeine; Dextropropoxyphene; Drug Combinations; Drug

2018
Salicytamide: a New Anti-inflammatory Designed Drug Candidate.
    Inflammation, 2018, Volume: 41, Issue:4

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Edema; Mice; Nocicepti

2018
Subcutaneous administration of paracetamol-Good local tolerability in palliative care patients: An observational study.
    Palliative medicine, 2018, Volume: 32, Issue:7

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Female; Humans; Male; Middl

2018
Pain in children remains an unsolved problem.
    Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:10

    Topics: Acetaminophen; Child; Emergency Service, Hospital; Humans; Ibuprofen; Pain

2018
Pain relief: determining the safety of ibuprofen with postpartum preeclampsia.
    American journal of obstetrics and gynecology, 2018, Volume: 218, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Hypertension; Ibuprofe

2018
Prevalence and Characteristics of Moderate to Severe Pain among Hospitalized Older Adults.
    Journal of the American Geriatrics Society, 2018, Volume: 66, Issue:9

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No

2018
Participation of ATP-sensitive K+ channels and μ-opioid receptors in the antinociceptive synergism of the paracetamol-tapentadol co-administration in the formalin-induced pain assay in mice.
    Drug development research, 2018, Volume: 79, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr

2018
There may be a small reduction in pain immediately after tooth bleaching when consuming codeine plus acetaminophen, but this is unlikely to be important to patients or worth the potential risks.
    Journal of the American Dental Association (1939), 2019, Volume: 150, Issue:3

    Topics: Acetaminophen; Codeine; Double-Blind Method; Drug Combinations; Humans; Ibuprofen; Pain; Tooth Bleac

2019
Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis.
    Human reproduction (Oxford, England), 2019, 03-01, Volume: 34, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Brain; Central Nervous System; Endometriosis;

2019
A Question of Opioid Diversion or Compliance.
    Clinical chemistry, 2019, Volume: 65, Issue:2

    Topics: Acetaminophen; Analgesics, Opioid; Brain Injuries, Traumatic; Chromatography, High Pressure Liquid;

2019
What Is the Optimal Dose of Predniso(lo)ne for Induction of Remission in Patients With Autoimmune Hepatitis?
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020, Volume: 18, Issue:8

    Topics: Acetaminophen; Hepatitis, Autoimmune; Humans; Pain; Prednisolone; Prednisone; Remission Induction

2020
Beyond Opioids for Pain Management in Adult Critically Ill Patients.
    Journal of pharmacy practice, 2019, Volume: 32, Issue:3

    Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia; Analgesics; Analgesics, Non-N

2019
Acetaminophen influences social and economic trust.
    Scientific reports, 2019, 03-11, Volume: 9, Issue:1

    Topics: Acetaminophen; Adult; Female; Games, Experimental; Humans; Interpersonal Relations; Male; Pain; Resi

2019
Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.
    Handbook of experimental pharmacology, 2020, Volume: 261

    Topics: Acetaminophen; Animals; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Narcotics; Pain;

2020
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017.
    Pain, 2019, Volume: 160, Issue:6

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age

2019
Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.
    International journal of molecular sciences, 2019, Apr-18, Volume: 20, Issue:8

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis,

2019
Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief.
    Pain medicine (Malden, Mass.), 2019, 11-01, Volume: 20, Issue:11

    Topics: Acetaminophen; Analgesia; Cesarean Section; Female; Humans; Pain; Pain Management; Pregnancy

2019
Use of paracetamol in ischaemic stroke patients: evidence from VISTA.
    Acta neurologica Scandinavica, 2013, Volume: 128, Issue:3

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Brain Ischemia; Female; Fever; Hum

2013
Semiological evaluation of pain according to its origin: a prospective, observational, and national study of current French medical practice.
    Current medical research and opinion, 2013, Volume: 29, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Combinations; Female; Fra

2013
Analgesics for osteoarthritis.
    American family physician, 2013, Mar-01, Volume: 87, Issue:5

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi

2013
Descriptive study of opioid-acetaminophen prescription patterns at the providence VA Medical Center.
    Rhode Island medical journal (2013), 2013, Jan-04, Volume: 96, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug

2013
To compare methods used in our operating room for alleviating tourniquet pain.
    JPMA. The Journal of the Pakistan Medical Association, 2013, Volume: 63, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St

2013
[Efficacy of tramadol/acetaminophen medication for central post-stroke pain].
    No shinkei geka. Neurological surgery, 2013, Volume: 41, Issue:8

    Topics: Acetaminophen; Aged; Female; Humans; Japan; Male; Middle Aged; Pain; Pain Measurement; Stroke; Trama

2013
Managing osteoarthritis pain in the older population.
    Journal of pain & palliative care pharmacotherapy, 2013, Volume: 27, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Age Factors; Aged; Aging; Analgesics,

2013
Does format matter for comprehension of a facial affective scale and a numeric scale for pain by adults with Down syndrome?
    Research in developmental disabilities, 2013, Volume: 34, Issue:10

    Topics: Acetaminophen; Adult; Affect; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cog

2013
Adult cancer pain.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2013, Volume: 11, Issue:8

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms; Pain;

2013
Is it farewell to codeine?
    Archives of disease in childhood, 2013, Volume: 98, Issue:12

    Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Child; Codeine; Humans; Pain; Treatment Outcom

2013
The pill hustle: risky pain management for a gunshot victim.
    Social science & medicine (1982), 2013, Volume: 99

    Topics: Acetaminophen; Adult; Anthropology, Cultural; Black or African American; Drug Combinations; Health S

2013
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
    Anesthesiology, 2014, Volume: 120, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce

2014
Acetaminophen (paracetamol).
    Journal of pain and symptom management, 2013, Volume: 46, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat

2013
Is fever treated more promptly than pain in the pediatric emergency department?
    The Journal of emergency medicine, 2014, Volume: 46, Issue:3

    Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Presch

2014
Intravenous acetaminophen: an alternative to opioids for pain management?
    Hospital pediatrics, 2013, Volume: 3, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Evidence-B

2013
Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcoti

2014
Identifying adults at risk of paracetamol toxicity in the acute dental setting: development of a clinical algorithm.
    British dental journal, 2014, Volume: 216, Issue:5

    Topics: Acetaminophen; Adult; Algorithms; Analgesics, Non-Narcotic; Dental Care; Drug Overdose; Health Knowl

2014
Acetaminophen safety: be cautious but not afraid. Read labels and stick to guidelines to prevent this widely used pain and fever remedy from harming your liver.
    Harvard men's health watch, 2014, Volume: 18, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat

2014
Using acetaminophen safely.
    The Johns Hopkins medical letter health after 50, 2014, Volume: 26, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat

2014
An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aged; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle

2014
Pharmacological management of pain in Australian Aged Care Facilities.
    Age and ageing, 2014, Volume: 43, Issue:6

    Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; An

2014
Patient recall of health care provider counseling for opioid-acetaminophen prescriptions.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:10

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Counseling; Cross-Sectional Studies; Drug Combinations; Fe

2014
Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity.
    Pharmacology, 2014, Volume: 93, Issue:5-6

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Drug Combinations; Drug Synergism; gamma-Aminobutyr

2014
Deadly pain pills: everyday, 46 people in the U.S. die from legal pain pills. Here's how to avoid being a statistic.
    Consumer reports, 2014, Volume: 79, Issue:9

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdos

2014
Clinical and pathologic characteristics of intranasal abuse of combined opioid-acetaminophen medications.
    International forum of allergy & rhinology, 2014, Volume: 4, Issue:10

    Topics: Acetaminophen; Administration, Intranasal; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid

2014
Methods for calculating confidence and credible intervals for the residual between-study variance in random effects meta-regression models.
    BMC medical research methodology, 2014, Sep-06, Volume: 14

    Topics: Acetaminophen; Analysis of Variance; Bayes Theorem; Confidence Intervals; Humans; Models, Statistica

2014
Rescheduling of hydrocodone combination products.
    The Medical letter on drugs and therapeutics, 2014, Oct-13, Volume: 56, Issue:1453

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Controlled Subs

2014
A high-quality RCT documents that elderly with dementia, the most neglected pain patients, have effective and safe pain relief from paracetamol alone or with buprenorphine patch.
    European journal of pain (London, England), 2014, Volume: 18, Issue:10

    Topics: Acetaminophen; Analgesics; Buprenorphine; Clinical Protocols; Dementia; Female; gamma-Aminobutyric A

2014
Pain in renal disease.
    Journal of pain & palliative care pharmacotherapy, 2014, Volume: 28, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cystostomy; Female; Humans; Pain; Pain Management; P

2014
Adaptation of an evidence-based clinical practice guideline in cancer pain management by medical oncologists: a case vignette study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015, Volume: 23, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Constipation; Cross-Sectional Studies; Evidence-Base

2015
Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context.
    Neuropharmacology, 2015, Volume: 91

    Topics: Acetaminophen; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Brain; Carrageenan; Hyperalgesia;

2015
"But it's just paracetamol": Caregivers' ability to administer over-the-counter painkillers to children with the information provided.
    Patient education and counseling, 2015, Volume: 98, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Caregivers; Child; Child, Preschool; Comprehension; Drug La

2015
Painful acute radiation thyroiditis induced by 131I treatment of Graves' disease.
    BMJ case reports, 2015, Jan-09, Volume: 2015

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Anti-Inflammatory Agents; Drug Combinations; Female; Grave

2015
Analgesic effects of rosemary essential oil and its interactions with codeine and paracetamol in mice.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Codeine; Drug Interactions; Female; Male; Mice; Oils, Volatile;

2015
DEA reschedules hydrocodone combination products.
    Pain practice : the official journal of World Institute of Pain, 2015, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Attitude to Health; Drug and Narcotic Control; Drug C

2015
Acetaminophen & children. Why have pediatric dosage guidelines changed, and what does it mean in practice?
    Advance for NPs & PAs, 2011, Volume: 2, Issue:12

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Preschool; Dose-Re

2011
A retrospective cohort study of long-term immediate-release hydrocodone/acetaminophen use and acetaminophen dosing above the Food and Drug Administration recommended maximum daily limit among commercially insured individuals in the United States (2008-201
    The journal of pain, 2015, Volume: 16, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cohor

2015
Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy.
    Pharmacological research, 2015, Volume: 97

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diabetic Neuropathies; Dose-Response Relationship, Drug

2015
Protein-Derived Acetaminophen-Cysteine Can Be Detected After Repeated Supratherapeutic Ingestion of Acetaminophen in the Absence of Hepatotoxicity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2015, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver In

2015
Optimal pain relief for pediatric MSK injury.
    Canadian family physician Medecin de famille canadien, 2015, Volume: 61, Issue:6

    Topics: Acetaminophen; Analgesics; Canada; Child; Codeine; Drug Combinations; Humans; Ibuprofen; Morphine; M

2015
Rationale for Use of Intravenous Acetaminophen in Special Operations Medicine.
    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2015,Summer, Volume: 15, Issue:2

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; First Aid; Humans; Military Me

2015
Patterning poly(maleic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer bioconjugates for controlled release of drugs.
    International journal of pharmaceutics, 2015, Sep-30, Volume: 493, Issue:1-2

    Topics: Acetaminophen; Analgesics; Animals; Codeine; Delayed-Action Preparations; Drug Carriers; Drug Libera

2015
Functional magnetic resonance imaging is a powerful approach to probing the mechanism of action of therapeutic drugs that act on the central nervous system.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Humans; Male; Pain

2015
Acetaminophen: minimal relief for knee arthritis pain.
    Harvard men's health watch, 2015, Volume: 19, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis; Humans; Knee Joint; Pain

2015
Formulation optimization of a drug in adhesive transdermal analgesic patch.
    Drug development and industrial pharmacy, 2016, Volume: 42, Issue:6

    Topics: Acetaminophen; Adhesives; Administration, Cutaneous; Analgesics; Animals; Chemistry, Pharmaceutical;

2016
Safety and Tolerability of Biphasic Immediate-Release/Extended-Release Oxycodone/Acetaminophen Tablets: Analysis of 11 Clinical Trials.
    Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:7

    Topics: Acetaminophen; Adult; Analgesics; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combin

2016
Protein-derived acetaminophen-cysteine detection from chronic APAP is not dose-dependent.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2015, Volume: 11, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cysteine; Female; Humans; Male; Pain

2015
Reply to Dr. Regina and colleagues re: protein-derived acetaminophen-cysteine in supratherapeutic ingestion.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2015, Volume: 11, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cysteine; Female; Humans; Male; Pain

2015
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
    The Journal of pediatrics, 2016, Volume: 168

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu

2016
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
    The Journal of pediatrics, 2016, Volume: 168

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu

2016
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
    The Journal of pediatrics, 2016, Volume: 168

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu

2016
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
    The Journal of pediatrics, 2016, Volume: 168

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu

2016
Comparison of intravenous morphine and paracetamol.
    Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2015, Volume: 23, Issue:5

    Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Ank

2015
Pain management during radiotherapy and radiochemotherapy in oropharyngeal cancer patients: single-institution experience.
    International dental journal, 2015, Volume: 65, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2015
Prevalence, trends, patterns and associations of analgesic use in Germany.
    BMC pharmacology & toxicology, 2015, Oct-01, Volume: 16

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics; Aspirin; Diclofenac; Drug Therapy;

2015
Combination of paracetamol or ketamine with meperidine enhances antinociception.
    Human & experimental toxicology, 2016, Volume: 35, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr

2016
NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent?
    Evidence-based medicine, 2016, Volume: 21, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2016
Treating Pain in Preterm Infants: Moving from Opioids to Acetaminophen.
    The Journal of pediatrics, 2016, Volume: 168

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Male; Morphine; Pain

2016
[INFULGAN-OPTIMAL ANALGETIC DRUG FOR USE IN LAPAROSCOPIC SURGERY].
    Klinichna khirurhiia, 2015, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Antipyretics; Appendectomy; Chil

2015
Nonsurgical Management of Knee Pain in Adults.
    American family physician, 2015, Nov-15, Volume: 92, Issue:10

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal;

2015
Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities.
    Drugs & aging, 2015, Volume: 32, Issue:12

    Topics: Acetaminophen; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ster

2015
Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding.
    Psychopharmacology, 2016, Volume: 233, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Benzofurans; Conditioning

2016
Pain medication in German nursing homes: a whole lot of metamizole.
    Pharmacoepidemiology and drug safety, 2016, Volume: 25, Issue:6

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Cross-Sectional Studies; Dipyrone; Dose-Response

2016
Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical an

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Prevention and Management of Procedural Pain in the Neonate: An Update.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics,

2016
Non-steroidal anti-inflammatory drugs and paracetamol in self-therapy of various disorders in students of different fields of study.
    Folia medica Cracoviensia, 2015, Volume: 55, Issue:2

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional Studies; Female; Heal

2015
Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs.
    Journal of veterinary pharmacology and therapeutics, 2016, Volume: 39, Issue:5

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Codeine;

2016
In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery.
    Evidence-based medicine, 2016, Volume: 21, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Infant, Newborn; Morphine; Pain

2016
Common pain relievers may increase heart problems. High-dosage ibuprofen and diclofenac linked to elevated risk of death; naproxen, acetaminophen offer alternatives.
    DukeMedicine healthnews, 2010, Volume: 16, Issue:9

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Ibuprofen; Naproxen; Pai

2010
Early management in children with burns: Cooling, wound care and pain management.
    Burns : journal of the International Society for Burn Injuries, 2016, Volume: 42, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Bandages; Burns; Child; Child, Preschool; Cryotherapy; Early

2016
Paracetamol + opium (Izalgi) higher-dose for oral administration. A poor choice for analgesia.
    Prescrire international, 2016, Volume: 25, Issue:168

    Topics: Acetaminophen; Administration, Oral; Drug Therapy, Combination; Humans; Opium; Pain

2016
Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better.
    Advances in therapy, 2016, Volume: 33, Issue:6

    Topics: Acetaminophen; Aged; Analgesics; Dose-Response Relationship, Drug; Drug Combinations; Drug Monitorin

2016
Paracetamol: pharmacology, prescribing and controversies.
    Archives of disease in childhood. Education and practice edition, 2016, Volume: 101, Issue:6

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans;

2016
What are the therapeutic alternatives to dextropropoxyphene in France? A prescribers' survey.
    Anaesthesia, critical care & pain medicine, 2017, Volume: 36, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesiologists; Anesthesiolog

2017
[Palliative medicine--drug therapy for cancer pain].
    Nihon rinsho. Japanese journal of clinical medicine, 2016, May-20, Volume: 74 Suppl 3

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Male; Pain; Pall

2016
Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients.
    Neurocritical care, 2016, Volume: 25, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80

2016
Unusual foreign body in primary tooth.
    BMJ case reports, 2016, Jul-05, Volume: 2016

    Topics: Acetaminophen; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Foreign Bodies; Humans; Male;

2016
The Decline in Hydrocodone/Acetaminophen Prescriptions in Emergency Departments in the Veterans Health Administration Between 2009 to 2015.
    The western journal of emergency medicine, 2016, Volume: 17, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Drug Prescriptions; Emergency Ser

2016
Experiences of Pain and Expectations for Its Treatment Among Former Buruli Ulcer Patients.
    The American journal of tropical medicine and hygiene, 2016, Nov-02, Volume: 95, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents

2016
Acetaminophen study yields new insights into neurobiological underpinnings of empathy.
    Journal of neurophysiology, 2017, 05-01, Volume: 117, Issue:5

    Topics: Acetaminophen; Emotions; Empathy; Humans; Pain; Social Behavior

2017
Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study.
    Clinical pediatrics, 2017, Volume: 56, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Antipyretics; Caregivers; Cross-Sectional Studies; Culture; Female

2017
Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study.
    Human reproduction (Oxford, England), 2017, Volume: 32, Issue:1

    Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Aspirin; Female; Humans; Ibuprofen; Internet;

2017
Teething.
    Nursing standard (Royal College of Nursing (Great Britain) : 1987), 2016, Nov-23, Volume: 31, Issue:13

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Humans; Ibuprofen; Infant; Materia Medica; Pain

2016
Prenatal acetaminophen use and outcomes in children.
    American journal of obstetrics and gynecology, 2017, Volume: 216, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans; Neurodevelo

2017
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
    CPT: pharmacometrics & systems pharmacology, 2017, Volume: 6, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In

2017
The relation between paracetamol use and asthma: a GA2LEN European case-control study.
    The European respiratory journal, 2008, Volume: 32, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Asthma; Case-Control Studies; Europe; Female; Humans; Male; Middle

2008
Acetaminophen prevents hyperalgesia in central pain cascade.
    Neuroscience letters, 2008, Sep-05, Volume: 442, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Dinoprostone; Hyperalgesia;

2008
Dextropropoxyphene: welcome withdrawal from a French hospital's formulary.
    Prescrire international, 2008, Volume: 17, Issue:95

    Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug Overdose; Drug Therapy, Combination; Dru

2008
Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:1

    Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Dose-Respo

2009
Listen to the patient.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:5

    Topics: Acetaminophen; Bicarbonates; Deglutition Disorders; Drug Combinations; Female; Fractures, Bone; Huma

2008
Pro-drugs for indirect cannabinoids as therapeutic agents.
    Current drug delivery, 2008, Volume: 5, Issue:4

    Topics: Acetaminophen; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Humans; Pain;

2008
GP management of osteoarthritic pain in Hong Kong.
    Australian family physician, 2008, Volume: 37, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional St

2008
Antinociceptive activity of swertiamarin isolated from Enicostemma axillare.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:2-3

    Topics: Acetaminophen; Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Gentianaceae; Glucosides;

2009
How to make screening mammography less uncomfortable.
    Medscape journal of medicine, 2008, Volume: 10, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen

2008
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk?
    Experimental physiology, 2009, Volume: 94, Issue:2

    Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and

2009
Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.
    European journal of pharmacology, 2009, Mar-01, Volume: 605, Issue:1-3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Disease Models, An

2009
The synergistic interaction between rilmenidine and paracetamol in the writhing test in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 379, Issue:6

    Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Th

2009
Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:2

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Dextropropoxyphene; Drug Overdose; Drug Therapy

2009
Survey of i.v. paracetamol (acetaminophen) use in neonates and infants under 1 year of age by UK anesthetists.
    Paediatric anaesthesia, 2009, Volume: 19, Issue:4

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anesthesia; Drug Utilization; Female; Health C

2009
Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis.
    European journal of pharmacology, 2009, Jun-24, Volume: 613, Issue:1-3

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dis

2009
[Update on current care guidelines. Safe use of non-steroidal anti-inflammatory drugs].
    Duodecim; laaketieteellinen aikakauskirja, 2009, Volume: 125, Issue:5

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Middle Aged

2009
Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009, Volume: 7, Issue:9

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Infl

2009
Comment from the editor on Lambertz et al in the September 2008 issue.
    Radiology, 2009, Volume: 251, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Lidocaine; Mammogra

2009
The analgesic effects of oral paracetamol in two strains of mice undergoing vasectomy.
    Laboratory animals, 2009, Volume: 43, Issue:4

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dose-Respo

2009
The analgesic effect of decursinol.
    Archives of pharmacal research, 2009, Volume: 32, Issue:6

    Topics: Acetaminophen; Acetic Acid; Analgesics; Angelica; Animals; Aspirin; Benzopyrans; Butyrates; Disease

2009
Antinociceptive activity of a new benzofuranone derived from a chalcone.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:4

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalc

2009
Acetaminophen safety - deja vu.
    The Medical letter on drugs and therapeutics, 2009, Jul-13, Volume: 51, Issue:1316

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Consumer Pro

2009
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
    Inflammopharmacology, 2009, Volume: 17, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitacea

2009
Aspirin or paracetamol - what's good for you?
    Journal of clinical pharmacy and therapeutics, 2009, Volume: 34, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical

2009
[Treatment of sickle cell pain].
    Le Mali medical, 2009, Volume: 24, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Child; Female; Humans; Mal

2009
Alleviation of pain associated with immunization injections.
    Indian pediatrics, 2009, Volume: 46, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Immunization; Injections; Pain; Vaccines

2009
Dextropropoxyphene: withdrawn in the EU. Withdrawn from pharmacies in France.
    Prescrire international, 2009, Volume: 18, Issue:102

    Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug and Narcotic Control; Drug Combinations;

2009
Dextropropoxyphene: withdrawal from the US market requested: harmful drug.
    Prescrire international, 2009, Volume: 18, Issue:102

    Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug and Narcotic Control; Drug Combinations;

2009
A determination of submicromolar concentrations of glycine in periaqueductal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection.
    Electrophoresis, 2009, Volume: 30, Issue:19

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Electric Conductivity; Electrophoresi

2009
A difficult balance--pain management, drug safety, and the FDA.
    The New England journal of medicine, 2009, Nov-26, Volume: 361, Issue:22

    Topics: Acetaminophen; Advisory Committees; Analgesics; Analgesics, Opioid; Drug and Narcotic Control; Drug

2009
Is acetaminophen safe? Accidental overdoses are common, but avoidable.
    Mayo Clinic women's healthsource, 2010, Volume: 14, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug

2010
Posttraumatic psoriatic osteitis of the frontal bone successfully treated with etanercept. Report of a case.
    Joint bone spine, 2010, Volume: 77, Issue:1

    Topics: Acetaminophen; Anti-Inflammatory Agents; Child; Craniocerebral Trauma; Drug Therapy, Combination; Et

2010
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
    Osteoarthritis and cartilage, 2010, Volume: 18, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Disease Mode

2010
Trauma and substance abuse: deadly consequences of intravenous percocet tablets.
    The Journal of emergency medicine, 2012, Volume: 43, Issue:3

    Topics: Acetaminophen; Adult; Craniocerebral Trauma; Drug Combinations; Emergency Service, Hospital; Facial

2012
[44 year old gardener with lower back pain, myalgia and fever].
    Praxis, 2010, Jan-20, Volume: 99, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Clinical Trials as T

2010
Synergism between COX-3 inhibitors in two animal models of pain.
    Inflammopharmacology, 2010, Volume: 18, Issue:2

    Topics: Acetaminophen; Animals; Cyclooxygenase Inhibitors; Dipyrone; Disease Models, Animal; Drug Synergism;

2010
Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice.
    Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:10

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Response

2009
Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents.
    Anesthesia and analgesia, 2010, Apr-01, Volume: 110, Issue:4

    Topics: Acetaminophen; Acetic Acid; Algorithms; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Carbamaz

2010
FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
    Inflammopharmacology, 2010, Volume: 18, Issue:2

    Topics: Acetaminophen; Advisory Committees; Alcohol Drinking; Analgesics, Opioid; Anti-Inflammatory Agents,

2010
Reducing delirium in elderly patients with hip fracture: a multi-factorial intervention study.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:6

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Anesthesia, General; Anesthesia, Spinal; Choline

2010
The value of the dental impaction pain model in drug development.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human

2010
The value of the dental impaction pain model in drug development.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human

2010
The value of the dental impaction pain model in drug development.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human

2010
The value of the dental impaction pain model in drug development.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human

2010
Pain prevalence in patients with chronic kidney disease.
    Clinical nephrology, 2010, Volume: 73, Issue:4

    Topics: Acetaminophen; Activities of Daily Living; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory

2010
Triage pain scales cannot predict analgesia provision to pediatric patients with long-bone fracture.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chi-Square Distribution; Ch

2010
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.
    European journal of obstetrics, gynecology, and reproductive biology, 2010, Volume: 152, Issue:1

    Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; M

2010
[Pain perception and pain therapy in premature infants].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2010, Volume: 29, Issue:5

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Infant;

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Acetaminophen reduces social pain: behavioral and neural evidence.
    Psychological science, 2010, Volume: 21, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio

2010
Effects of high dose orally administered paracetamol for heel prick pain in premature infants.
    Saudi medical journal, 2010, Volume: 31, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Heel; Humans; Infant, New

2010
Re: lack of benefit from paracetamol (acetaminophen) for palliative cancer patients.
    Journal of pain and symptom management, 2010, Volume: 40, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method

2010
Individualized pharmacological treatment of oral mucositis pain in patients with head and neck cancer receiving radiotherapy.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011, Volume: 19, Issue:9

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2011
Bundle up: it's painful out there--the case for opioid-acetaminophen combinations.
    Clinical pharmacology and therapeutics, 2010, Volume: 88, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Humans; Pain; Produc

2010
Predictors of pain relief and adverse events in patients receiving opioids in a prehospital setting.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:5

    Topics: Acetaminophen; Adult; Aged; Ambulances; Analgesics, Non-Narcotic; Analgesics, Opioid; Confidence Int

2011
Retiform hemangioendothelioma presenting as a hyperhidrotic tumor.
    International journal of dermatology, 2010, Volume: 49, Issue:9

    Topics: Acetaminophen; Biopsy; Female; Hemangioendothelioma; Humans; Hyperhidrosis; Middle Aged; Pain; Skin

2010
Blood pressure destabilization on nonsteroidal antiinflammatory agents: acetaminophen exposed?
    Circulation, 2010, Nov-02, Volume: 122, Issue:18

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Dos

2010
A primer on pain relief.
    Consumer reports, 2010, Volume: 75, Issue:11

    Topics: Acetaminophen; Analgesia; Analgesics; Aspirin; Humans; Ibuprofen; Naproxen; Nonprescription Drugs; P

2010
Risk of hepatotoxicity-related hospitalizations among patients treated with opioid/acetaminophen combination prescription pain medications.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Drug Combina

2010
A 3-year-old trauma patient with progressive paralysis.
    Journal of emergency nursing, 2010, Volume: 36, Issue:6

    Topics: Accidents, Traffic; Acetaminophen; Analgesics, Non-Narcotic; Catheters, Indwelling; Child, Preschool

2010
Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients.
    Saudi medical journal, 2010, Volume: 31, Issue:12

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Drug Therapy, Combination; Female; Humans; Male; Middle Age

2010
Acetaminophen induces apoptosis in rat cortical neurons.
    PloS one, 2010, Dec-10, Volume: 5, Issue:12

    Topics: Acetaminophen; Animals; Antioxidants; Antipyretics; Apoptosis; Benzimidazoles; Cytochrome P-450 CYP2

2010
Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception.
    Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, An

2011
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice;

2011
Pain management of children and adolescents with sickle cell disease presenting to the emergency department.
    Saudi medical journal, 2011, Volume: 32, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Anti-I

2011
The pharmacokinetics of intravenous paracetamol in neonates: size matters most.
    Archives of disease in childhood, 2011, Volume: 96, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Drug Administration Schedule; Gestational Age;

2011
Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain.
    Obstetrics and gynecology, 2011, Volume: 117, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Hydr

2011
Pain perception during and after VNUS ClosureFAST™ procedure.
    Phlebology, 2011, Volume: 26, Issue:5

    Topics: Acetaminophen; Aged; Catheter Ablation; Cohort Studies; Female; Humans; Male; Middle Aged; Pain; Pai

2011
Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:3

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug;

2011
Pain relief in neonates: when to use intravenous paracetamol.
    Archives of disease in childhood, 2011, Volume: 96, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Administration Schedule; Humans; Infant, Newborn; Inje

2011
Acetaminophen may boost blood pressure. Caution, attention should accompany routine use of any pain medicine.
    Harvard heart letter : from Harvard Medical School, 2011, Volume: 21, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Pressure; Heart Rate; Humans; Hypertension; Pain; Vas

2011
Antinociceptive effects of combination of tramadol and acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2011, Volume: 49, Issue:1

    Topics: Acetaminophen; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combin

2011
Adherence and long-term effect of oxycodone/paracetamol in chronic noncancer pain: a retrospective study.
    Advances in therapy, 2011, Volume: 28, Issue:5

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; M

2011
FDA limits prescription acetaminophen. But be vigilant about over-the-counter acetaminophen, too.
    Harvard women's health watch, 2011, Volume: 18, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat

2011
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
    Neuro endocrinology letters, 2011, Volume: 32, Issue:2

    Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Celecoxib; Codein

2011
Pediatric pain management.
    Pediatric annals, 2011, Volume: 40, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Human

2011
Is there a role for intravenous acetaminophen in pediatric emergency departments?
    Pediatric emergency care, 2011, Volume: 27, Issue:6

    Topics: Acetaminophen; Adolescent; Analgesia; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Hum

2011
Rapid hypnosis as an anaesthesia adjunct for evacuation of postpartum vulval haematoma.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2011, Volume: 51, Issue:3

    Topics: Acetaminophen; Adult; Anesthetics, Intravenous; Blood Loss, Surgical; Female; Fentanyl; Hematoma; Hu

2011
Medication, surgery, and physiotherapy among patients with the hypermobility type of Ehlers-Danlos syndrome.
    Archives of physical medicine and rehabilitation, 2011, Volume: 92, Issue:7

    Topics: Acetaminophen; Activities of Daily Living; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti

2011
Misuse of acetaminophen in the management of dental pain.
    Pharmacoepidemiology and drug safety, 2011, Volume: 20, Issue:9

    Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum

2011
Fatigue in knee and hip osteoarthritis: the role of pain and physical function.
    Rheumatology (Oxford, England), 2011, Volume: 50, Issue:10

    Topics: Acetaminophen; Activities of Daily Living; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-S

2011
Effects of the analgesic acetaminophen (Paracetamol) and its para-aminophenol metabolite on viability of mouse-cultured cortical neurons.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:2

    Topics: Acetaminophen; Aminophenols; Analgesics; Animals; Brain; Cell Survival; Cells, Cultured; Mice; Mice,

2012
Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations.
    Annals of the rheumatic diseases, 2011, Volume: 70, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Knee Joint; Male; Pain

2011
Use of acetaminophen (paracetamol) as a short-term adjunctive analgesic in a laminitic pony.
    Veterinary anaesthesia and analgesia, 2011, Volume: 38, Issue:5

    Topics: Acetaminophen; Analgesia; Analgesics; Animals; Fatal Outcome; Foot Diseases; Hoof and Claw; Horse Di

2011
[Pain assessment in terminally-ill cancer patients on admission in hospice and its modification after the first three days of care. A monocentric experience].
    La Clinica terapeutica, 2011, Volume: 162, Issue:5

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Drug Therapy, Combination;

2011
Suspected opioid overdose case resolved by CYP2D6 genotyping.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Caffeine; Codeine; Cytochrome P-450 CYP2D6; Drug Comb

2012
Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens.
    Journal of dietary supplements, 2010, Volume: 7, Issue:2

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Antipyretics; Behavior, Animal; Bignoniaceae; Disea

2010
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
    BMC complementary and alternative medicine, 2012, May-02, Volume: 12

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A

2012
Alternating acetaminophen and ibuprofen for pain in children.
    Canadian family physician Medecin de famille canadien, 2012, Volume: 58, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

2012
Intrapartum fetal pain management in lethal osteogenesis imperfecta.
    Prenatal diagnosis, 2012, Volume: 32, Issue:10

    Topics: Acetaminophen; Adult; Analgesia; Breech Presentation; Fatal Outcome; Female; Fetal Diseases; Humans;

2012
[Mechanism of action of paracetamol--further contribution to discovery].
    Pharmazie in unserer Zeit, 2012, Volume: 41, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Calcium Channels; Dronabinol; H

2012
Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria.
    BMC pediatrics, 2012, Jul-19, Volume: 12

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Caregivers; Child; Child, Preschool; Dru

2012
Older adults living with osteoarthritis: examining the relationship of age and gender to medicine use.
    Canadian journal on aging = La revue canadienne du vieillissement, 2012, Volume: 31, Issue:3

    Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents

2012
The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study.
    European journal of pain (London, England), 2013, Volume: 17, Issue:3

    Topics: Acetaminophen; Administration, Topical; Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Ant

2013
Use of intravenous acetaminophen (paracetamol) in a pediatric patient at the end of life: case report.
    Journal of palliative medicine, 2013, Volume: 16, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fatal Outcome; Female; Humans; Injections, Intraveno

2013
Effect of pain management on immunization efficacy in mice.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2012, Volume: 51, Issue:4

    Topics: Acetaminophen; Analgesia; Analgesics; Animals; Animals, Laboratory; Antibody Formation; Behavior, An

2012
Basic pain relievers. It's wise to use caution.
    Mayo Clinic health letter (English ed.), 2012, Volume: 30, Issue:9

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induc

2012
Association of pain score documentation and analgesic use in a pediatric emergency department.
    Pediatric emergency care, 2012, Volume: 28, Issue:12

    Topics: Acetaminophen; Administration, Oral; Adolescent; Age Factors; Analgesics; Child; Child, Preschool; D

2012
Prescription patterns of pain medicine physicians.
    Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:6

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Drug Prescriptions; Humans; Methadone; Opioid-Related

2013
Subcutaneous migration of a central venous catheter.
    Clinical nutrition (Edinburgh, Scotland), 2013, Volume: 32, Issue:4

    Topics: Acetaminophen; Aged; Catheterization, Central Venous; Central Venous Catheters; Female; Foreign-Body

2013
Non-prescription medicines for pain and fever--a comparison of recommendations and counseling from staff in pharmacy and general sales stores.
    Health policy (Amsterdam, Netherlands), 2013, Volume: 110, Issue:1

    Topics: Acetaminophen; Analgesics; Antipyretics; Aspirin; Child; Commerce; Contraindications; Counseling; Fe

2013
Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors.
    Neuroscience letters, 2013, Mar-01, Volume: 536

    Topics: Acetaminophen; Adenosine A1 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Male; Mice; Mic

2013
Can intravenous paracetamol reduce opioid use in preoperative hip fracture patients?
    Orthopedics, 2013, Volume: 36, Issue:2 Suppl

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hip Fr

2013
Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology.
    Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:9

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care Facilities;

2013
Pain management in the elderly.
    The Journal of the American Osteopathic Association, 2002, Volume: 102, Issue:9

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Pain; Pain Management; Pa

2002
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Acetaminophen; Aging; Analgesics; Animals; Aspirin; Clomipramine; Dose-Response Relationship, Drug;

2002
Medicine: lipid signals in pain control.
    Nature, 2002, Nov-14, Volume: 420, Issue:6912

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygen

2002
Re: combination analgesic efficacy.
    Journal of pain and symptom management, 2002, Volume: 24, Issue:3

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinatio

2002
Guidelines on pain control in seniors favor certain NSAIDs and strategies for the cognitively impaired.
    Report on medical guidelines & outcomes research, 2002, Jun-28, Volume: 13, Issue:12

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cognition Disorders; Human

2002
Acetaminophen and hypertension: a causal association or pain mediated?
    Archives of internal medicine, 2003, May-12, Volume: 163, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Ca

2003
Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: a novel heat allodynia model sensitive to analgesics.
    British journal of pharmacology, 2003, Volume: 139, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Diclofenac; Diterpenes; Dose-Response Relationship, Drug; Female

2003
Switching from i.v. to p.o.
    The American journal of nursing, 2003, Volume: 103, Issue:5

    Topics: Acetaminophen; Administration, Oral; Drug Combinations; Humans; Infusions, Intravenous; Male; Narcot

2003
Paracetamol is the drug of choice for childhood pain and fever.
    Journal of the Irish Dental Association, 2003, Volume: 49, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Infant; Pain

2003
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No

2003
The sublingual administration of curare.
    California medicine, 1953, Volume: 79, Issue:3

    Topics: Acetaminophen; Administration, Sublingual; Curare; Humans; Mephenesin; Pain; Pain Management; Tubocu

1953
[Napatyl, a new analgesic; clinical evaluation of N-acetyl-p-aminophenol with codeine].
    Ugeskrift for laeger, 1956, Nov-29, Volume: 118, Issue:48

    Topics: Acetaminophen; Acetanilides; Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Codeine; P

1956
USE OF A 'SOMA' COMPOUND IN PAIN CONTROL AFTER ORAL SURGERY.
    Journal of oral surgery, anesthesia, and hospital dental service, 1963, Volume: 21

    Topics: Acetaminophen; Amphetamine; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthesia, Dental; An

1963
[CLINICAL TRIALS WITH LONARID IN ORTHOPEDICS].
    Die Medizinische Welt, 1964, May-02, Volume: 18

    Topics: Acetaminophen; Biomedical Research; Fractures, Bone; Humans; Joint Diseases; Orthopedic Procedures;

1964
ETHCHLORVYNOL AND PARACETAMOL. A CLINICAL EVALUATION OF AN HYPNOTIC/ANALGESIC COMBINATION.
    The British journal of clinical practice, 1964, Volume: 18

    Topics: Acetaminophen; Analgesics; Biomedical Research; Drug Synergism; Drug Therapy; Ethchlorvynol; Humans;

1964
Paracetamol for injection: new formulation. New formulation: why so widely used?
    Prescrire international, 2003, Volume: 12, Issue:67

    Topics: Acetaminophen; Adult; Child; Clinical Trials as Topic; Drug Approval; Fever; France; Humans; Infusio

2003
Administering acetaminophen safely.
    Nursing, 2003, Volume: 33, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Interactions; Drug Overdose; Humans; Pain

2003
Older adults with Alzheimer disease, comorbid arthritis and prescription of psychotropic medications.
    Pain research & management, 2003,Winter, Volume: 8, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Alzheimer Disease; Analgesics; Arthritis; Benzodiazepines; C

2003
Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age.
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:1

    Topics: Acetaminophen; Analgesia; Analgesics; Betamethasone; Birth Weight; Female; Gestational Age; Half-Lif

2004
Stability of tramadol hydrochloride--acetaminophen (Ultracet) in strawberry syrup and in a sugar-free vehicle.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2004, Jan-01, Volume: 61, Issue:1

    Topics: Acetaminophen; Analgesics, Opioid; Child; Chromatography, High Pressure Liquid; Dosage Forms; Drug C

2004
Paracetamol + tramadol: new preparation. No advance.
    Prescrire international, 2003, Volume: 12, Issue:68

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codein

2003
Information from your family doctor. Chronic pain medicines.
    American family physician, 2004, Mar-01, Volume: 69, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise

2004
Information from your family doctor. Pain relievers: understanding your options.
    American family physician, 2004, Mar-01, Volume: 69, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Decision Making; Humans;

2004
Weak opiate analgesics: modest practical merits.
    Prescrire international, 2004, Volume: 13, Issue:69

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2004
The complexity of managing pain for frail elders.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:5

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise

2004
Acetaminophen dose accuracy and pediatric emergency care.
    Pediatric emergency care, 2004, Volume: 20, Issue:5

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflamma

2004
Analgesic prescription patterns among hemodialysis patients in the DOPPS: potential for underprescription.
    Kidney international, 2004, Volume: 65, Issue:6

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cycloo

2004
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal;

2004
Pain--the enigmatic entity.
    Journal of the Indian Medical Association, 2004, Volume: 102, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions;

2004
[Systematic pain treatment following Colles' fracture].
    Ugeskrift for laeger, 2004, May-24, Volume: 166, Issue:22

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2004
A 64 year old woman with knee pain: case outcome.
    BMJ (Clinical research ed.), 2004, Jul-03, Volume: 329, Issue:7456

    Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Decision Making; Drug Interactions; Femal

2004
A prospective study of nurse initiated panadeine forte: expanding pain management in the ED.
    Accident and emergency nursing, 2004, Volume: 12, Issue:3

    Topics: Acetaminophen; Adult; Analgesia; Australia; Clinical Nursing Research; Clinical Protocols; Codeine;

2004
Future Pain Drugs - Europe 2003. 15-16 September 2003, London, UK.
    IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:11

    Topics: Acetaminophen; Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A

2003
Antalgic effect and clinical tolerability of hyaluronic acid in patients with degenerative diseases of knee cartilage: an outpatient treatment survey.
    Drugs under experimental and clinical research, 2004, Volume: 30, Issue:2

    Topics: Acetaminophen; Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Dru

2004
Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats.
    Neuroscience letters, 2004, Sep-16, Volume: 368, Issue:1

    Topics: Acetaminophen; Acetylcholine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Stero

2004
Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients.
    Archives of internal medicine, 2004, Nov-22, Volume: 164, Issue:21

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Combinatio

2004
Balancing pain and analgesic treatment in the home-dwelling elderly.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; An

2005
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:1

    Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Human

2005
Treating pain after Vioxx. Should you switch to another COX-2, a traditional non-steroidal anti-inflammatory, or acetaminophen.
    Health news (Waltham, Mass.), 2005, Volume: 11, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inh

2005
Acetaminophen in cancer pain.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Mar-01, Volume: 23, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Neoplasms; Pain; Palliative Care

2005
[Arthrosis pain: a frequent problem. Paracetamol is the first choice according to EULAR recommendation].
    Praxis, 2005, Feb-02, Volume: 94, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Arthritis; Clinical Trials as Topic; Humans; Multice

2005
Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice.
    Pharmacology, 2005, Volume: 74, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Behavior, Animal; Cytokines; Dose-Response Relationship

2005
[Data recording using a personal digital assistant. Experience of prospective survey on pain in 3196 patients].
    Presse medicale (Paris, France : 1983), 2005, Mar-12, Volume: 34, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Computers, Handheld; Data Collection; Family Practice; Fema

2005
Rates of abuse of tramadol remain unchanged with the introduction of new branded and generic products: results of an abuse monitoring system, 1994-2004.
    Pharmacoepidemiology and drug safety, 2005, Volume: 14, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Drug Prescriptions; Drugs, Generic; Humans; Narcotics; Opioid-Rel

2005
Bupivacaine versus lidocaine analgesia for neonatal circumcision.
    BMC pediatrics, 2005, May-22, Volume: 5, Issue:1

    Topics: Acetaminophen; Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; C

2005
[Aspirin, paracetamol, ibuprofen: analgesics in the family medicine cabinet].
    Revue de l'infirmiere, 2005, Issue:110

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraind

2005
Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain.
    Journal of anesthesia, 2005, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-

2005
Are nursing home patients with dementia diagnosis at increased risk for inadequate pain treatment?
    International journal of geriatric psychiatry, 2005, Volume: 20, Issue:8

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Cognition Disorders; C

2005
Report of an adverse incident in a randomized clinical trial.
    Journal of orthodontics, 2005, Volume: 32, Issue:3

    Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Child; Drug Hypers

2005
Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:4

    Topics: Accidents, Traffic; Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Barbi

2005
Opioids for non-operable osteoarthritis and soft-tissue rheumatism.
    Arthritis research & therapy, 2005, Volume: 7, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents,

2005
Pharmaceutical prescribing for children. Part 2. Analgesia and prescribing for children in pain.
    Primary dental care : journal of the Faculty of General Dental Practitioners (UK), 2005, Volume: 12, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammato

2005
Circadian pattern of spontaneous behavior in monarthritic rats: a novel global approach to evaluation of chronic pain and treatment effectiveness.
    Arthritis and rheumatism, 2005, Volume: 52, Issue:11

    Topics: Acetaminophen; Activity Cycles; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri

2005
Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs.
    The Journal of rheumatology, 2005, Volume: 32, Issue:11

    Topics: Acetaminophen; Adult; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Data Colle

2005
Managing patients with cancer and advanced liver disease.
    Palliative medicine, 2005, Volume: 19, Issue:7

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Contraindicatio

2005
Determining pain levels in patients treated with maggot debridement therapy.
    Journal of wound care, 2005, Volume: 14, Issue:10

    Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic;

2005
Patient's page. Bone health facts.
    Southern medical journal, 2005, Volume: 98, Issue:11

    Topics: Acetaminophen; Adult; Child; Child Abuse; Chronic Disease; Female; Humans; Male; Pain; Pain Manageme

2005
Use of acetaminophen in young subelite athletes.
    The Journal of sports medicine and physical fitness, 2005, Volume: 45, Issue:4

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Bicycling; Case-Control S

2005
Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice.
    European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3

    Topics: Acetaminophen; Adenosine A2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Caffeine; Centr

2006
Paediatric prehospital analgesia in Auckland.
    Emergency medicine Australasia : EMA, 2006, Volume: 18, Issue:1

    Topics: Acetaminophen; Adolescent; Age Factors; Analgesia; Analgesics; Burns; Child; Child, Preschool; Drug

2006
Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain.
    Pain, 2006, Volume: 121, Issue:1-2

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Stero

2006
Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine.
    Pharmacological research, 2006, Volume: 53, Issue:4

    Topics: Acetaminophen; Animals; Aspirin; Brain; Caffeine; Corpus Striatum; Dopamine; Male; Norepinephrine; P

2006
Common pain reliever may promote social interaction in people with dementia.
    Health news (Waltham, Mass.), 2006, Volume: 12, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Dementia; Humans; Interpersonal Relations; Pain

2006
Drug therapy in dental practice: nonopioid and opioid analgesics.
    Anesthesia progress, 2005,Winter, Volume: 52, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2005
Pain relievers and alcohol. A potentially risky combination.
    Mayo Clinic health letter (English ed.), 2006, Volume: 24, Issue:5

    Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Interacti

2006
Glucosamine and chondroitin sulfate for knee osteoarthritis.
    The New England journal of medicine, 2006, May-18, Volume: 354, Issue:20

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfat

2006
[Paracetamol has the same effect as non-steroidal anti-inflammatory agents in acute musculoskeletal injuries].
    Ugeskrift for laeger, 2006, May-15, Volume: 168, Issue:20

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans

2006
Comparison of a scheduled narcotic for chronic pain with a similar medication for breakthrough pain only is not a clinically relevant comparison.
    The American journal of managed care, 2006, Volume: 12, Issue:7

    Topics: Acetaminophen; Chronic Disease; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Therapy, Co

2006
Antinociceptive effects of synthetic chalcones obtained from xanthoxyline.
    Archiv der Pharmazie, 2006, Volume: 339, Issue:7

    Topics: Acetaminophen; Acetic Acid; Acetophenones; Administration, Oral; Analgesics; Animals; Aspirin; Chalc

2006
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2006, Volume: 13, Issue:8

    Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba

2006
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes;

2006
[Dextromethorphan enhances analgesic activity of propacetamol--experimental study].
    Folia medica Cracoviensia, 2005, Volume: 46, Issue:1-2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response

2005
Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Acetaminophen; Acute Disease; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, N

2007
Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system.
    Molecular pharmacology, 2007, Volume: 71, Issue:2

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Animals; Cyclooxygenase Inhibitors; Mitogen-Acti

2007
Tramadol infusion for the pain management in sickle cell disease: a case report.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:1

    Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch

2007
Is killing the pain worth the risk?
    BMJ (Clinical research ed.), 2007, Jan-27, Volume: 334, Issue:7586

    Topics: Acetaminophen; Analgesics; Dextropropoxyphene; Drug Approval; Drug Combinations; Humans; Pain; Unite

2007
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:4

    Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima

2007
Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.
    European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Dose-Response Rela

2007
Comparing effectiveness of pain relievers in children.
    Child health alert, 2007, Volume: 25

    Topics: Acetaminophen; Adolescent; Analgesics; Child; Codeine; Emergencies; Humans; Pain; Wounds and Injurie

2007
Acute pain in adults admitted to the emergency room: development and implementation of abbreviated guidelines.
    Swiss medical weekly, 2007, Apr-21, Volume: 137, Issue:15-16

    Topics: Acetaminophen; Acute Disease; Algorithms; Analgesics, Non-Narcotic; Analgesics, Opioid; Decision Tre

2007
[Ankylosing spondylarthritis--what is new in diagnosis and therapy?].
    Deutsche medizinische Wochenschrift (1946), 2006, Oct-27, Volume: Suppl 1

    Topics: Acetaminophen; Antibodies, Monoclonal; Antirheumatic Agents; Diagnosis, Differential; Humans; Pain;

2006
Do we need to incorporate pharmacogenetics in randomized, controlled trials of frequently used medicines?
    Pediatrics, 2007, Volume: 120, Issue:1

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

2007
Intraoperative analgesia for day-care surgery: practice trends.
    JPMA. The Journal of the Pakistan Medical Association, 2007, Volume: 57, Issue:6

    Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anal

2007
Intravenous paracetamol for pain relief in a patient with neuropathic pain.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:7

    Topics: Acetaminophen; Amputation, Surgical; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Infusions

2007
[Ambulatory pain management for children in the family practice].
    MMW Fortschritte der Medizin, 2007, Jul-19, Volume: 149, Issue:29-30

    Topics: Acetaminophen; Acute Disease; Ambulatory Care; Analgesics; Analgesics, Opioid; Child; Chronic Diseas

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Acetaminophen toxicity: changing perceptions on a social/medical issue.
    Hepatology (Baltimore, Md.), 2007, Volume: 46, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug and Narcotic Control; Drug Industry; Drug Labeling; Hu

2007
Periosteal reaction in systemic lupus erythematosus.
    Joint bone spine, 2007, Volume: 74, Issue:6

    Topics: Acetaminophen; Analgesics, Opioid; Female; Femur; Humans; Knee; Lupus Erythematosus, Systemic; Osteo

2007
Introduction and audit of intravenous paracetamol at a tertiary paediatric teaching hospital.
    Anaesthesia and intensive care, 2007, Volume: 35, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Australia; Child; Child, Preschool; Drug Utiliz

2007
Primary care treatment of knee pain--a survey in older adults.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:11

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cryotherapy; Exerc

2007
Acetaminophen reinforces descending inhibitory pain pathways.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1

    Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain;

2008
Acetaminophen reinforces descending inhibitory pain pathways.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1

    Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain;

2008
Acetaminophen reinforces descending inhibitory pain pathways.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1

    Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain;

2008
Acetaminophen reinforces descending inhibitory pain pathways.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1

    Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain;

2008
Analgesic efficacy of orodispersible paracetamol in patients admitted to the emergency department with an osteoarticular injury.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2007, Volume: 14, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bone and Bones; Emergency Service, Hospital; Female;

2007
Antinociceptive action of limonexic acid obtained from Raulinoa echinata.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:11

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Dru

2007
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 88, Issue:4

    Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; An

2008
Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Attitude to Death; Codeine; D

2008
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
    Prescrire international, 2007, Volume: 16, Issue:92

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical

2007
Frontal lobotomy for the relief of intractable pain.
    The Southern surgeon, 1950, Volume: 16, Issue:2

    Topics: Acetaminophen; Frontal Lobe; Humans; Pain; Pain Management; Pain, Intractable; Personality; Personal

1950
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
    British journal of pharmacology, 2008, Volume: 153, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Dipyrone; Disease Models, Animal; Hyp

2008
Imatinib-induced fatal acute liver failure.
    World journal of gastroenterology, 2007, Dec-28, Volume: 13, Issue:48

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzamides; Fatal Outcome; Female; H

2007
Pain medications. What you should know.
    Mayo Clinic health letter (English ed.), 2007, Volume: 25, Issue:9

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Hum

2007
[Atypical pain in the mandible caused by trigeminal neuralgia].
    Nederlands tijdschrift voor tandheelkunde, 2008, Volume: 115, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Diagnosis, Differential; Female; Humans; Magnetic Resonance

2008
Use of over-the-counter analgesics in patients with chronic liver disease: physicians' recommendations.
    Drug safety, 2008, Volume: 31, Issue:3

    Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

2008
[Pharmacotherapy with zaldiar of the pain syndrome in diabetic polyneuropathy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007, Volume: 107, Issue:9

    Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Diab

2007
Hepatic tolerance of repeated intravenous paracetamol administration in neonates.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Belgium; Humans; Infant; Infant, Newborn; Injections, Intra

2008
Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl-phenolamine (AM404) in the rat: comparison with paracetamol.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 377, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Frontal Lobe; Hydroxyindoleacet

2008
Pain management in Swedish neonatal units--a national survey.
    Acta paediatrica (Oslo, Norway : 1992), 2008, Volume: 97, Issue:7

    Topics: Acetaminophen; Analgesics; Data Collection; Guideline Adherence; Humans; Infant, Newborn; Intensive

2008
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
    Pain, 2008, Sep-30, Volume: 139, Issue:1

    Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug

2008
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
    Pain, 2008, Sep-30, Volume: 139, Issue:1

    Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug

2008
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
    Pain, 2008, Sep-30, Volume: 139, Issue:1

    Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug

2008
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
    Pain, 2008, Sep-30, Volume: 139, Issue:1

    Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug

2008
Efficiency of a muscle relaxant-analgesic combination in general practice.
    The British journal of clinical practice, 1967, Volume: 21, Issue:1

    Topics: Acetaminophen; Humans; Muscles; Orphenadrine; Pain

1967
Interaction of analgesic effects of psychopharmaca.
    Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 170, Issue:2

    Topics: Acetaminophen; Analgesics; Animals; Antidepressive Agents; Central Nervous System; Drug Antagonism;

1967
Acute renal failure after acetaminophen ingestion.
    JAMA, 1982, Feb-19, Volume: 247, Issue:7

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Amylases; Creatine Kinase; Female; Humans; Liver; Pain; T

1982
The management of the patient with chronic pain due to advanced malignancy.
    Journal of medicine, 1982, Volume: 13, Issue:3

    Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Drug Therapy, Combination; Humans; Narcotics; N

1982
Strained abdominal muscles as a cause of acute abdominal pain in children and young adults and its treatment with Paramax.
    The British journal of clinical practice, 1983, Volume: 37, Issue:5

    Topics: Abdomen; Abdominal Muscles; Acetaminophen; Adolescent; Adult; Child; Drug Combinations; Female; Huma

1983
Peripherally acting analgesics.
    The American journal of medicine, 1984, Sep-10, Volume: 77, Issue:3A

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Aspirin; Diflunisal; Fenoprofen; Humans; Ibupro

1984
Pain and inflammation.
    The American journal of medicine, 1984, Sep-10, Volume: 77, Issue:3A

    Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Osteoarthritis; Pai

1984
The influence of paracetamol on the anti-inflammatory, the anti-pyretic and the analgesic activity of indomethacin.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 265, Issue:1

    Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Indo

1983
Gastric emptying and drug absorption before surgery.
    British journal of anaesthesia, 1984, Volume: 56, Issue:2

    Topics: Acetaminophen; Adult; Aged; Anxiety; Emergencies; Female; Gastric Emptying; Humans; Intestinal Absor

1984
Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis.
    The Medical journal of Australia, 1984, Feb-18, Volume: 140, Issue:4

    Topics: Acetaminophen; Arthritis, Rheumatoid; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Dr

1984
Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 268, Issue:2

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Codeine; Dextropropoxyphene; Male; Mefenamic Acid; Mice

1984
Acetaminophen: a practical pharmacologic overview.
    Canadian Medical Association journal, 1984, Jul-01, Volume: 131, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Child; Child, Preschool; Fever; Humans; Infant; Kidney; Liver; Met

1984
[Weighing the risk of weakly active analgesics. Paraminophenol and pyrazole derivatives. Conclusion].
    MMW, Munchener medizinische Wochenschrift, 1982, Mar-05, Volume: 124, Issue:9

    Topics: Acetaminophen; Humans; Pain; Phenacetin; Pyrazoles; Risk

1982
How to relieve your patients' pain fast and effectively ... with oral analgesics.
    Nursing, 1980, Volume: 10, Issue:11

    Topics: Acetaminophen; Administration, Oral; Analgesics; Aspirin; Humans; Narcotics; Pain

1980
Evaluation of acetaminophen and aspirin in the relief of preoperative dental pain.
    Journal of the American Dental Association (1939), 1980, Volume: 100, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Mouth Diseases;

1980
Pharmacological treatment of cancer pain with special reference to the oral use of morphine.
    Acta anaesthesiologica Scandinavica. Supplementum, 1982, Volume: 74

    Topics: Acetaminophen; Administration, Oral; Aspirin; Biological Availability; Chronic Disease; Codeine; Hum

1982
Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children.
    American journal of diseases of children (1960), 1982, Volume: 136, Issue:11

    Topics: Acetaminophen; Adolescent; Aspirin; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; F

1982
[Paracetamol, pharmacodynamic, clinical toxicology and pharmacokinetic].
    Medizinische Klinik (Praxis-Ausg.), 1982, Sep-10, Volume: 77, Issue:19

    Topics: Acetaminophen; Dose-Response Relationship, Drug; Fever; Half-Life; Humans; Intestinal Absorption; Ki

1982
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Feb-20, Volume: 56, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E

1980
Newer concepts in pain therapy by applied pharmacology of the analgesics.
    Delaware medical journal, 1981, Volume: 53, Issue:2

    Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Humans; Hydroxyzine; Morphine; Morphine Derivat

1981
Potentiation of acetaminophen hepatotoxicity by alcohol.
    JAMA, 1980, Jul-18, Volume: 244, Issue:3

    Topics: Acetaminophen; Adult; Alcoholism; Drug Synergism; Ethanol; Humans; Liver; Male; Middle Aged; Necrosi

1980
How safe is acetaminophen?
    JAMA, 1980, Jul-18, Volume: 244, Issue:3

    Topics: Acetaminophen; Aspartate Aminotransferases; Drug Synergism; Ethanol; Humans; Liver; Microsomes, Live

1980
A four-drug pain regimen for head and neck cancers.
    The Laryngoscope, 1994, Volume: 104, Issue:6 Pt 1

    Topics: Acetaminophen; Adult; Aged; Antidepressive Agents, Tricyclic; Drug Administration Schedule; Drug The

1994
Relative potency of two preparations in two-way elimination of heterogeneity designs with multivariate responses.
    Biometrics, 1995, Volume: 51, Issue:3

    Topics: Acetaminophen; Analgesia; Analgesics; Biometry; Caffeine; Dentistry; Humans; Mathematics; Models, St

1995
[Treatment of pain and anxiety in terminal oncologic patients in the Castilla-La Mancha community].
    Atencion primaria, 1995, Sep-30, Volume: 16, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anxiety; Female; Humans; Ma

1995
Non-steroidal anti-inflammatory drugs in elderly people. Treat mild chronic pain with paracetamol initially.
    BMJ (Clinical research ed.), 1995, Aug-05, Volume: 311, Issue:7001

    Topics: Acetaminophen; Aged; Chronic Disease; Humans; Pain

1995
Post-operative morbidity following paediatric tonsillectomy; a comparison of bipolar diathermy dissection and blunt dissection.
    International journal of pediatric otorhinolaryngology, 1995, Volume: 31, Issue:1

    Topics: Acetaminophen; Adenoidectomy; Adolescent; Child; Child, Preschool; Diathermy; Female; Hemorrhage; Hu

1995
[Drugs for relief of pain].
    La Revue du praticien, 1994, Sep-15, Volume: 44, Issue:14

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive

1994
Management of cancer pain: adults. Agency for Health Care Policy and Research.
    American journal of hospital pharmacy, 1994, Jul-01, Volume: 51, Issue:13

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Behavior Therapy; C

1994
[Paracetamol].
    Soins; la revue de reference infirmiere, 1994, Issue:583

    Topics: Acetaminophen; Fever; Humans; Pain

1994
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1993, Jan-08, Volume: 35, Issue:887

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy

1993
Paracetamol and acute biliary pain with cholestasis.
    Lancet (London, England), 1993, Oct-02, Volume: 342, Issue:8875

    Topics: Acetaminophen; Acute Disease; Adult; Cholestasis; Female; Humans; Pain

1993
Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:7

    Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Drug Combinations; Drug Synergism; Female; H

1993
Alternatives to non-steroidal anti-inflammatory drugs (NSAIDS)
    The Medical journal of Australia, 1993, Sep-20, Volume: 159, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Australia; Humans; Pain; Sodium Salicylate

1993
Osteoarthritis treatment update. Minimizing pain while limiting patient risk.
    Postgraduate medicine, 1993, Volume: 93, Issue:1

    Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Stero

1993
The formalin test in the naked mole-rat (Heterocephalus glaber): analgesic effects of morphine, nefopam and paracetamol.
    Brain research, 1993, Jan-08, Volume: 600, Issue:1

    Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Formalde

1993
Is prescribing paracetamol 'pro re nata' acceptable?
    Journal of paediatrics and child health, 1993, Volume: 29, Issue:2

    Topics: Acetaminophen; Child; Child, Preschool; Drug Administration Schedule; Drug Utilization; Fever; Human

1993
12 years on: coproxamol revisited.
    Lancet (London, England), 1996, Jun-29, Volume: 347, Issue:9018

    Topics: Acetaminophen; Dextropropoxyphene; Drug Combinations; Drug Utilization; Humans; Pain

1996
The effect of acetaminophen, ibuprofen, and misoprostol on prostaglandin E2 synthesis and the degree and rate of orthodontic tooth movement.
    The Angle orthodontist, 1996, Volume: 66, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Inflammatory Agents, No

1996
Mothers' attitudes and behavior toward medicating children's pain.
    Pain, 1996, Volume: 67, Issue:2-3

    Topics: Acetaminophen; Adult; Attitude to Health; Child; Child, Preschool; Female; Humans; Maternal Behavior

1996
Naloxone-reversible antinociception by paracetamol in the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Acetaminophen; Animals; Cerebral Cortex; Formaldehyde; Hot Temperature; Ketanserin; Kinetics; Male;

1997
Acetaminophen in the management of background pain in children post-burn.
    Journal of pain and symptom management, 1997, Volume: 13, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Burns; Child; Child, Preschool; Humans; Pain; Retrospective

1997
Hair opiates during pain treatment.
    Forensic science international, 1997, Jan-17, Volume: 84, Issue:1-3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Codeine; Gas Chromatography-Mass Spectrometry; Hair; Humans

1997
Neonatal abstinence syndrome due to codeine.
    Archives of disease in childhood. Fetal and neonatal edition, 1997, Volume: 76, Issue:1

    Topics: Acetaminophen; Adult; Codeine; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome;

1997
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class.
    Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-

1997
[The physiological properties of the action of a new analgesic and antipyretic preparation].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 1997, Volume: 43, Issue:1-2

    Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroid

1997
[The use of the preparation Solpadeine in dental practice].
    Stomatologiia, 1997, Volume: 76, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caff

1997
[Pancreatic pain in cholecystectomized patients after taking paracetamol and codeine].
    Atencion primaria, 1997, Nov-30, Volume: 20, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cholecystectomy; Codeine; Headache; Hum

1997
Management of sickle cell disease. Non-addictive analgesics can be as effective as morphine and pethidine.
    BMJ (Clinical research ed.), 1998, Mar-21, Volume: 316, Issue:7135

    Topics: Acetaminophen; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Combi

1998
Pain relief in children. Doing the simple things better.
    BMJ (Clinical research ed.), 1998, May-23, Volume: 316, Issue:7144

    Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Humans; Pain; Pain Measurement

1998
Co-proxamol is effective in chronic pain.
    BMJ (Clinical research ed.), 1998, Jun-27, Volume: 316, Issue:7149

    Topics: Acetaminophen; Chronic Disease; Dextropropoxyphene; Drug Combinations; Humans; Pain; Treatment Outco

1998
Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
    Journal of ethnopharmacology, 1998, Volume: 61, Issue:1

    Topics: Abdomen; Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No

1998
North of England evidence based guideline development project: summary guideline for non-steroidal anti-inflammatory drugs versus basic analgesia in treating the pain of degenerative arthritis. The North of England Non-Steroidal Anti-Inflammatory Drug Gui
    BMJ (Clinical research ed.), 1998, Aug-22, Volume: 317, Issue:7157

    Topics: Acetaminophen; Activities of Daily Living; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Codei

1998
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033

    Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics

1998
AGS clinical practice guidelines: the management of chronic pain in older persons.
    Geriatrics, 1998, Volume: 53 Suppl 3

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age

1998
Tramadol or hydrocodone-acetaminophen for acute musculoskeletal pain?
    The Journal of family practice, 1998, Volume: 47, Issue:5

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Opioid; Double-Blind Method; Drug

1998
Analgesics in the management of chronic pain. Part two: Step I analgesic drug therapy.
    Intensive & critical care nursing, 1998, Volume: 14, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; H

1998
Perioperative pharmacodynamics of acetaminophen analgesia in children.
    Anesthesiology, 1999, Volume: 90, Issue:2

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesia; Analgesics, Non-Narcotic; Ch

1999
Tramadol: new preparation. Capsules: central analgesic; step 2 on the WHO scale.
    Prescrire international, 1998, Volume: 7, Issue:33

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Doub

1998
Who gives pain relief to children?
    Journal of accident & emergency medicine, 1999, Volume: 16, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesia; Analgesics; Child; Child, Preschool; Emergency Medical Service

1999
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.
    Anesthesiology, 1999, Volume: 91, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dinoprostone; Male; Pain; Rats; Rats, Sprague-Dawl

1999
[Chronic pain during dialysis. Pharmacologic therapy and its costs].
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 1999, Volume: 51, Issue:2

    Topics: Acetaminophen; Analgesics; Arthralgia; Buprenorphine; Chronic Disease; Codeine; Disability Evaluatio

1999
Analgesia in soft-tissue injury: current practice in Auckland is not supported by the available evidence.
    The New Zealand medical journal, 1999, Oct-08, Volume: 112, Issue:1097

    Topics: Acetaminophen; Adult; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

1999
[The association of patient with painful ophthalmoplegia and cluster headache: do they have a single physiopathological mechanism?].
    Neurologia (Barcelona, Spain), 1999, Volume: 14, Issue:8

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents; Cluste

1999
Parental guidance suggested. Pediatric fever and pain relief require expert input.
    Advance for nurse practitioners, 1999, Volume: 7, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Education; Fever; Humans; Ibuprofe

1999
Novalgin in pain and fever.
    JPMA. The Journal of the Pakistan Medical Association, 1999, Volume: 49, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Dipyrone; Female; Humans; Infant;

1999
Profound hearing loss associated with hydrocodone/acetaminophen abuse.
    The American journal of otology, 2000, Volume: 21, Issue:2

    Topics: Acetaminophen; Adult; Analgesics; Cochlear Implantation; Disease Progression; Drug Combinations; Fem

2000
An audit of patient perception compared with medical and nursing staff estimation of pain during burn dressing changes.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Ana

2000
Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects.
    Behavioural brain research, 2000, Volume: 112, Issue:1-2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dipyrone; Disinfectants; Dose-Re

2000
Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity.
    British journal of pharmacology, 2000, Volume: 130, Issue:7

    Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Ede

2000
Drugs for pain.
    The Medical letter on drugs and therapeutics, 2000, Aug-21, Volume: 42, Issue:1085

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2000
Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus.
    Die Pharmazie, 2000, Volume: 55, Issue:12

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Cultur

2000
NCCN Practice Guidelines for Cancer Pain.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:11A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Neoplasms; Pain; Pain Measureme

2000
Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain.
    The Journal of rheumatology, 2001, Volume: 28, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Area Under Curve; Drug Therapy, Co

2001
[Eccrine neutrophilic hidradenitis: idiopathic plantar form in children].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2001, Volume: 8, Issue:3

    Topics: Acetaminophen; Activities of Daily Living; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory A

2001
Who's feeling no pain?
    Time, 2001, Mar-19, Volume: 157, Issue:11

    Topics: Acetaminophen; Analgesics; Drug Combinations; Humans; Hydrocodone; Pain; Substance-Related Disorders

2001
[Prevalence and management of pain in a hospital: a cross-sectional study].
    Presse medicale (Paris, France : 1983), 2001, Mar-31, Volume: 30, Issue:12

    Topics: Acetaminophen; Adult; Age Factors; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; A

2001
The position of paracetamol in the world of analgesics.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nonprescri

2000
The effect of a paracetamol and morphine combination on dynorphin A levels in the rat brain.
    Biochemical pharmacology, 2001, Jun-01, Volume: 61, Issue:11

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Drug Combin

2001
[Liver and renal tolerance to paracetamol: 3 g or 4 g per day?].
    Presse medicale (Paris, France : 1983), 2001, Apr-21, Volume: 30, Issue:15

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Chemical and Drug Induced Live

2001
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
    International journal of tissue reactions, 2001, Volume: 23, Issue:1

    Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid

2001
Drug-seeking behavior--a differential approach.
    The Journal of the Oklahoma State Medical Association, 2001, Volume: 94, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Pain; Pain Management

2001
The influence of divalent cations on the analgesic effect of opioid and non-opioid drugs.
    Pharmacological research, 2001, Volume: 43, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blood Pressure; Butorphanol; C

2001
Codeine for child pain: new preparation. Helpful in some cases.
    Prescrire international, 1999, Volume: 8, Issue:42

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1999
Pain management. Medication update.
    Southern medical journal, 2001, Volume: 94, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclooxygenase Inhibitors

2001
Pain experience during transvaginal aspiration of immature oocytes.
    Acta obstetricia et gynecologica Scandinavica, 2001, Volume: 80, Issue:11

    Topics: Acetaminophen; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-An

2001
Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.
    Brain research, 2001, Dec-07, Volume: 921, Issue:1-2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Behavior, Animal; Cyclooxygenase Inhibito

2001
Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital.
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:6

    Topics: Acetaminophen; Analgesics, Opioid; Australia; Cathartics; Chemotherapy, Adjuvant; Computer Simulatio

2001
Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Barbiturates; Caffeine; Carrageenan; Dose-Response

2001
[Step-children of pain therapy. The newborn suffer particularly severely].
    MMW Fortschritte der Medizin, 2001, Nov-15, Volume: 143, Issue:46

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Bupiva

2001
[Minimally invasive surgery for diverticula of the thoracic esophagus. Results in 11 patients].
    Gastroenterologie clinique et biologique, 2001, Volume: 25, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesia; Diverticulum, Esophageal; Female; Humans; Laparos

2001
New, non-NSAID alternative.
    The Nurse practitioner, 2002, Volume: 27, Issue:2

    Topics: Acetaminophen; Acute Disease; Analgesics; Drug Approval; Drug Combinations; Humans; Pain; Tramadol;

2002
[Effective not only in rheumatism and arthrosis. Rofecoxib fights also acute pain].
    MMW Fortschritte der Medizin, 2002, Feb-14, Volume: 144, Issue:7

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents

2002
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
    European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles;

2002
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
    European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles;

2002
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
    European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles;

2002
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
    European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles;

2002
Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups.
    Farmaco (Societa chimica italiana : 1989), 2002, Volume: 57, Issue:5

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Benzimidazoles; Escherichia coli; Female; Guinea Pi

2002
[Clinical studies with the new two-component analgesic Panagesic].
    MMW, Munchener medizinische Wochenschrift, 1979, Jul-20, Volume: 121, Issue:29-30

    Topics: Acetaminophen; Adult; Aged; Analgesics; Burns; Drug Combinations; Drug Evaluation; Female; Fractures

1979
Inflammation and the role of endogenous pain-producing substances.
    Dental clinics of North America, 1978, Volume: 22, Issue:1

    Topics: Acetaminophen; Anti-Inflammatory Agents; Bradykinin; Histamine; Humans; Inflammation; Kallikreins; K

1978
Pain control in endodontics.
    Dental clinics of North America, 1979, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics; Aspirin; Cellulitis; Codeine; Dextropropoxyphene; Humans; Nausea; Pain; P

1979
Simple analgesics in rheumatoid arthritis.
    Scottish medical journal, 1977, Volume: 22, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Synergism; Human

1977
Analgesic requirements after orthognathic surgery.
    Journal of oral surgery (American Dental Association : 1965), 1976, Volume: 34, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Female; Humans; Male; Malocclusion; Meperidin

1976
Diagnosis of hypothyroidism after a surgical complication.
    Journal of oral surgery (American Dental Association : 1965), 1975, Volume: 33, Issue:5

    Topics: Acetaminophen; Adult; Humans; Hypothyroidism; Male; Oral Hemorrhage; Pain; Postoperative Complicatio

1975
Analgesics--the choice.
    Queen's nursing journal, 1976, Volume: 19, Issue:4

    Topics: Acetaminophen; Aspirin; Gastrointestinal Hemorrhage; Humans; Pain

1976
Letter: Acetaminophen.
    Clinical pediatrics, 1975, Volume: 14, Issue:4

    Topics: Acetaminophen; Child; Humans; Pain; Rheumatic Fever

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Comparison of fixed interval and visual analogue scales for rating chronic pain.
    European journal of clinical pharmacology, 1975, Aug-14, Volume: 8, Issue:6

    Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male;

1975
Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents.
    European journal of pharmacology, 1976, Volume: 37, Issue:1

    Topics: Acetaminophen; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carragee

1976
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
    Southern medical journal, 1992, Volume: 85, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory

1992
Survey of pain management therapy provided for children with sickle cell disease.
    Clinical pediatrics, 1992, Volume: 31, Issue:4

    Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Administratio

1992
Reaction time in cancer patients receiving peripherally acting analgesics alone or in combination with opioids.
    Acta anaesthesiologica Scandinavica, 1992, Volume: 36, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum

1992
Pharmacokinetic/pharmacodynamic analysis of the interaction between acetaminophen and caffeine.
    Proceedings of the Western Pharmacology Society, 1992, Volume: 35

    Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Chromatography, High Pressure Liquid; Drug S

1992
Pain during burn dressing change in children: relationship to burn area, depth and analgesic regimens.
    Pain, 1991, Volume: 47, Issue:1

    Topics: Acetaminophen; Adolescent; Bandages; Burns; Child; Female; Humans; Male; Morphine; Oxycodone; Pain;

1991
Effects of paracetamol and aspirin on neural activity of joint mechanonociceptors in adjuvant arthritis.
    British journal of pharmacology, 1991, Volume: 104, Issue:1

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; E

1991
NSAIDs, musculoskeletal disorders and gastrointestinal adverse effects.
    Australian family physician, 1991, Volume: 20, Issue:12

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Gastrointestinal Hemorr

1991
Nonnarcotic analgesics and tricyclic antidepressants for the treatment of chronic nonmalignant pain.
    The Mount Sinai journal of medicine, New York, 1991, Volume: 58, Issue:3

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic

1991
Treatment of watery mouth in lambs.
    The Veterinary record, 1991, Jul-20, Volume: 129, Issue:3

    Topics: Acetaminophen; Animals; Escherichia coli Infections; Pain; Sheep; Sheep Diseases

1991
The underutilization of oxycodone.
    Journal of pain and symptom management, 1991, Volume: 6, Issue:7

    Topics: Acetaminophen; Adult; Anus Neoplasms; Drug Combinations; Female; Humans; Oxycodone; Pain

1991
Advertising acyclovir.
    Lancet (London, England), 1990, Mar-24, Volume: 335, Issue:8691

    Topics: Acetaminophen; Acyclovir; Advertising; Herpes Zoster; Humans; Pain

1990
Pharmacologic agents for pain management.
    Critical care nursing clinics of North America, 1991, Volume: 3, Issue:1

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Narcotics; Pain

1991
Women to have more say in births?
    Australian College of Midwives Incorporated journal, 1990, Volume: 3, Issue:2

    Topics: Acetaminophen; Aspirin; Codeine; Female; Humans; Pain; Pregnancy; Pregnancy Complications

1990
Pharmaco-toxicological effects of acetaminophen in rodents. Battery of tests to screen potential analgesic acetaminophen derivatives.
    Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-St

1990
Simple analgesics preferable to NSAIDs for the elderly.
    Irish medical journal, 1990, Volume: 83, Issue:2

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pa

1990
Acetaminophen hepatotoxicity in the alcoholic.
    Southern medical journal, 1990, Volume: 83, Issue:9

    Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr

1990
Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin.
    Life sciences, 1985, Nov-11, Volume: 37, Issue:19

    Topics: Acetaminophen; Animals; Aspirin; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Inje

1985
Drug management of pain in cancer patients.
    Canadian Medical Association journal, 1985, Jun-01, Volume: 132, Issue:11

    Topics: Acetaminophen; Humans; Neoplasms; Pain; Palliative Care

1985
Ibuprofen vs acetaminophen in children.
    The Medical letter on drugs and therapeutics, 1989, Dec-15, Volume: 31, Issue:807

    Topics: Acetaminophen; Child; Drug Overdose; Fever; Humans; Ibuprofen; Pain; Suspensions

1989
Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation.
    Bone marrow transplantation, 1989, Volume: 4, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Bone Marrow Transplantation; Codeine; Drug Administrat

1989
The use of methotrimeprazine (Levoprome) in a patient sensitive to opioids and possible bowel shutdown.
    Journal of pain and symptom management, 1989, Volume: 4, Issue:1

    Topics: Acetaminophen; Adenocarcinoma; Female; Humans; Intestinal Obstruction; Lung Neoplasms; Methotrimepra

1989
[Paracetamol].
    Krankenpflege Journal, 1989, Apr-01, Volume: 27, Issue:4

    Topics: Acetaminophen; Fever; Humans; Pain

1989
Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model.
    Brain research, 1989, May-29, Volume: 488, Issue:1-2

    Topics: Acetaminophen; Animals; Arthritis; Arthritis, Experimental; Aspirin; Male; Pain; Rats; Rats, Inbred

1989
Pain-relief in sickle cell crisis.
    Lancet (London, England), 1986, Aug-09, Volume: 2, Issue:8502

    Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Bone and Bones; Child; Humans; Pain; Recurrence

1986
Analgesics in the management of acute pain.
    Clinical therapeutics, 1986, Volume: 9, Issue:1

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dru

1986
Current modalities in arthritic diseases.
    The American journal of medicine, 1987, Oct-30, Volume: 83, Issue:4B

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthrit

1987
[3-step pharmacologic treatment of pain in cancer. Preliminary experience in Chile].
    Revista medica de Chile, 1988, Volume: 116, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Chile; Codeine; Drug Administration Schedule; Female; Follow-Up St

1988
FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice.
    Life sciences, 1988, Volume: 43, Issue:11

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Disease Mode

1988
Nonnarcotic analgesic abuse. A common biopsychosocial problem.
    General hospital psychiatry, 1988, Volume: 10, Issue:2

    Topics: Acetaminophen; Aged; Analgesics; Behavior Therapy; Female; Humans; Marriage; Multiple Sclerosis; Pai

1988
[Drug treatment for pain].
    Tandlaegebladet, 1986, Volume: 90, Issue:4

    Topics: Acetaminophen; Analgesics; Anesthetics, Local; Aspirin; Humans; Kinetics; Pain; Psychotropic Drugs

1986
Central analgesic effect of paracetamol manifested by depression of nociceptive activity in thalamic neurones of the rat.
    Neuroscience letters, 1987, Jun-26, Volume: 77, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Drug Interactions; Evoked Potentials; Female; Male; Naloxone; Pa

1987
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain.
    Pain, 1987, Volume: 30, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphin

1987
[Therapy of pain caused by gastrointestinal tumors].
    Leber, Magen, Darm, 1987, Volume: 17, Issue:4

    Topics: Acetaminophen; Aspirin; Bone Diseases; Dipyrone; Humans; Injections, Epidural; Narcotics; Neoplasms;

1987
[Analgesics in general practice].
    Klinische Wochenschrift, 1986, Mar-17, Volume: 64, Issue:6

    Topics: Acetaminophen; Analgesics; Dipyrone; Dose-Response Relationship, Drug; Drug Combinations; Humans; Pa

1986
The effect of acetaminophen administration on its disposition and body stores of sulphate.
    European journal of clinical pharmacology, 1986, Volume: 30, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Female; Humans; Male; Pain; Sulfates; Time Factors

1986
[Paracetamol activity against pain provoked by different stimuli. Influence of aminergic mechanisms].
    Il Farmaco; edizione pratica, 1986, Volume: 41, Issue:8

    Topics: Acetaminophen; Animals; Biogenic Amines; Male; Pain; Rats

1986
Orphenadrine citrate increases and prolongs the antinociceptive effects of paracetamol in mice.
    Acta pharmacologica et toxicologica, 1986, Volume: 59, Issue:1

    Topics: Acetaminophen; Animals; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Mal

1986
[Analgesics in dental practice].
    ZWR, 1985, Volume: 94, Issue:11

    Topics: Acetaminophen; Analgesics; Dental Care; Drug Combinations; Humans; Pain; Pain, Postoperative; Pyrazo

1985
Use of simple analgesics in rheumatoid arthritis.
    Annals of the rheumatic diseases, 1985, Volume: 44, Issue:1

    Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis, Rheumatoid; Dextropropoxyphene; Drug Combinations

1985
Differentiation of peripheral and central effects of analgesic drugs.
    International journal of tissue reactions, 1985, Volume: 7, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diclofenac; Male; Morphine; Pain; Rabbits; Reflex

1985
[Evaluation of the analgesic activity of a preconstituted combination of acetylsalicylic acid, paracetamol and caffeine].
    La Clinica terapeutica, 1985, Oct-31, Volume: 115, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Drug Combinations; Drug Evaluation; Female; Hum

1985
Pain in haemophilia.
    Lancet (London, England), 1973, Apr-07, Volume: 1, Issue:7806

    Topics: Acetaminophen; Analgesics; Hemophilia A; Humans; Indomethacin; Male; Meperidine; Oxyphenbutazone; Pa

1973
Pain in haemophilia.
    Lancet (London, England), 1973, May-05, Volume: 1, Issue:7810

    Topics: Acetaminophen; Analgesics; Aspirin; Codeine; Cryotherapy; Gastrointestinal Hemorrhage; Headache; Hem

1973
Control of pain by drugs.
    Physiotherapy, 1974, Volume: 60, Issue:5

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Aspirin; Humans; Morphine; Pain; Tranquilizing Agents

1974
[Clinical observations and analgesic properties of the association of paracetamol and phenylbutazone].
    Revista brasileira de medicina, 1966, Volume: 23, Issue:9

    Topics: Acetaminophen; Back Pain; Contusions; Ear Diseases; Headache; Humans; Joint Diseases; Muscular Disea

1966
A comparison of propoxyphene HCl (Darvon) and an analgesic mixture (Percogesic) in pain relief after gingivectomy.
    Journal of oral therapeutics and pharmacology, 1967, Volume: 4, Issue:3

    Topics: Acetaminophen; Adult; Analgesics; Atropine; Caffeine; Dextropropoxyphene; Female; Gingivectomy; Hist

1967
[Clinical study of a new antalgic: Propofan].
    Lyon medical, 1972, Jan-23, Volume: 227, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His

1972
[Clinical evaluation of a new analgesic. (Study of 1000 cases)].
    Therapeutique (La Semaine des hopitaux), 1972, Volume: 48, Issue:10

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Child; Evaluation Studies as Topic; Female; Huma

1972
[Clinical experiences with a new analgetic-antipyretic drug combination in pediatrics].
    Medizinische Klinik, 1973, Jan-26, Volume: 68, Issue:4

    Topics: Acetaminophen; Child; Child, Preschool; Dextropropoxyphene; Drug Combinations; Fever; Humans; Infant

1973
Arthralgia and myalgia in mumps.
    Rheumatology and rehabilitation, 1973, Volume: 12, Issue:2

    Topics: Acetaminophen; Adult; Arthritis; Blood Cell Count; Fever; Hematocrit; Hemoglobins; Humans; Male; Mum

1973
Effects of caffeine on the absorption and analgesic efficacy of paracetamol in rats.
    Pharmacology, 1973, Volume: 10, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Caffeine; Depression, Chemical; Dose-Respo

1973
[Oluprin--a clinical study of a new analgesic].
    Medizinische Klinik, 1970, Feb-13, Volume: 65, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Proteins; Child; Evaluation Studies as Topic; Female;

1970
Analgetic drugs--the mild analgetics.
    The New England journal of medicine, 1972, Jan-06, Volume: 286, Issue:1

    Topics: Acetaminophen; Acetanilides; Administration, Oral; Analgesics; Aspirin; Codeine; Dextropropoxyphene;

1972
[Practical experience with Neuramag sine].
    Zeitschrift fur Allgemeinmedizin, 1972, Apr-30, Volume: 48, Issue:12

    Topics: Acetaminophen; Adult; Aged; Aspirin; Caffeine; Chemical Phenomena; Chemistry; Drug Combinations; Fem

1972
[Study of a new combination of analgesic substances].
    Hospital (Rio de Janeiro, Brazil), 1965, Volume: 67, Issue:5

    Topics: Acetaminophen; Adult; Caffeine; Female; Humans; Male; Pain; Salicylamides

1965
[Analgesic effect of the compound paracetamol-phenylbutazone].
    Hospital (Rio de Janeiro, Brazil), 1967, Volume: 72, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Pain; Phenylbutazone

1967
[Parazolidin R in odontogenic pain].
    Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:1

    Topics: Acetaminophen; Alveolectomy; Humans; Pain; Periapical Abscess; Periodontitis; Phenylbutazone; Tooth

1968
[Pain treatment with Oluprin].
    Therapie der Gegenwart, 1969, Volume: 108, Issue:9

    Topics: Acetaminophen; Humans; Pain; Phenylbutazone

1969
[Experiences with the new analgesic Oluprin].
    Therapie der Gegenwart, 1970, Volume: 109, Issue:4

    Topics: Acetaminophen; Analgesics; Humans; Pain; Phenylbutazone

1970
Paracetamol overdose.
    British medical journal, 1971, Jun-19, Volume: 2, Issue:5763

    Topics: Acetaminophen; Adult; Blood Sedimentation; Cell Migration Inhibition; Dysmenorrhea; Erythema; Female

1971
A device for measuring the threshold of pain in man.
    British journal of pharmacology, 1968, Volume: 34, Issue:2

    Topics: Acetaminophen; Achilles Tendon; Analgesia; Aspirin; Female; Humans; Male; Methods; Pain; Pharmacolog

1968
The analgetic properties of m-trifluoromethyl acetanilide.
    Arzneimittel-Forschung, 1968, Volume: 18, Issue:6

    Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperatur

1968
[Requirements for an analgesic therapy in a military medical practice].
    Die Therapiewoche, 1965, Volume: 15, Issue:14

    Topics: Acetaminophen; Analgesics; Germany, West; Humans; Military Medicine; Pain

1965
[On treatment of the "pain" symptom in obstetric and gynecologic pathology].
    La Clinica ostetrica e ginecologica, 1965, Volume: 67, Issue:9

    Topics: Acetaminophen; Female; Genital Diseases, Female; Humans; Muscles; Pain

1965
Treatment of insomnia complicated by pain using a chloral hydrate paracetamol complex.
    The British journal of clinical practice, 1966, Volume: 20, Issue:10

    Topics: Acetaminophen; Chloral Hydrate; Drug Synergism; Humans; Pain; Sleep Initiation and Maintenance Disor

1966