acetaminophen has been researched along with Ache in 1152 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acetaminophen, the active ingredient found in Tylenol, is among the most common pain medications consumed." | 9.69 | Acetaminophen changes Mu rhythm power related to pain empathy. ( Jelsone-Swain, L; McCommon, SA; Roach, A; Turk, B, 2023) |
| "This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)." | 9.51 | The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022) |
| "This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM." | 9.51 | The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022) |
| "Intranasal fentanyl seems to be a safe and effective alternative to acetaminophen with hydrocodone in reducing pain and improving hydration status in children with painful infectious mouth lesions and poor oral intake." | 9.51 | Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions. ( Chen, JG; Cramm, K; Florez, C; Papa, L; Ramirez, J; Ruffin, TB; Salinero, E, 2022) |
| " The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography." | 9.51 | Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022) |
| " Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo." | 9.51 | Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study. ( Aktaş, N; Arslan, E; Aydın, İ; Gülaçtı, U; Sönmez, C; Turgut, K; Yavuz, E, 2022) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 9.41 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023) |
| "The study aimed to compare the acetaminophen administration efficacy or its combination with codeine for pain control in acute apical abscesses cases." | 9.41 | Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial. ( Cardoso, MBF; da Rosa, RA; da Silva, PB; do Nascimento, AL; Mendes, AT; Pereira, JR; Só, MVR, 2021) |
| " The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)." | 9.41 | Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021) |
| " Lidocaine given intravenously has been shown in two small, uncontrolled studies to have an appreciable effect on pain after burns." | 9.34 | Lidocaine infusion has a 25% opioid-sparing effect on background pain after burns: A prospective, randomised, double-blind, controlled trial. ( Abdelrahman, I; Elmasry, M; Sjoberg, F; Steinvall, I, 2020) |
| "The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial." | 9.34 | Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020) |
| "To evaluate the effectiveness of verbal behavior modification, acetaminophen, and the combined effectiveness of verbal behavior modification along with acetaminophen on orthodontic pain." | 9.30 | A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. ( Abraham, R; Bansal, N; Kaur, H, 2019) |
| "We addressed these issues by investigating how acetaminophen administration and daily forgiveness are associated with experiences of social pain over 21 days." | 9.30 | Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen. ( Deal, BD; Gregory, A; Shields, GS; Slavich, GM; Toussaint, LL, 2019) |
| " Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups." | 9.30 | Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. ( Azami, A; Enteshari-Moghaddam, A; Habibzadeh, A; Isazadehfar, K; Jahanpanah, P; Mohebbi, H, 2019) |
| "To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection." | 9.30 | Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. ( Jongjidpranitarn, M; Nimmaanrat, S; Oofuvong, M; Prathep, S, 2019) |
| "There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED." | 9.27 | Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. ( Cattermole, GN; Graham, CA; Hung, KKC; Leung, LY; Leung, YK; Lo, RSL; Man, SY; Rainer, TH; Woo, WK, 2018) |
| "The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features." | 9.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department." | 9.27 | Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018) |
| "This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery." | 9.27 | Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. ( de Kam, ML; Groeneveld, GJ; Hay, JL; Siebenga, P; van Amerongen, G, 2018) |
| "Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants." | 9.22 | Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022) |
| "HNC patients (pts) receiving CRT were randomized to standard pain control (SPC) with acetaminophen and opioids, or SPC plus gabapentin (SPC+G)." | 9.22 | Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer. ( Chayahara, N; Fujiwara, Y; Funakoshi, Y; Kataoka, T; Kiyota, N; Komori, T; Minami, H; Mukohara, T; Nibu, K; Sasaki, R; Shimada, T; Toyoda, M, 2016) |
| "The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator." | 9.22 | Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial. ( Ghadirian, H; Hosseinzadeh Nik, T; Ostad, SN; Shahsavari, N, 2016) |
| "Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking." | 9.22 | Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016) |
| "Although liposomal bupivacaine had some effect on soft tissue anesthesia, it did not reduce pain to manageable clinical levels in patients presenting with untreated, symptomatic irreversible pulpitis." | 9.22 | Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( Beck, M; Bultema, K; Drum, M; Fowler, S; Nusstein, J; Reader, A, 2016) |
| " Significant reduction in pain intensity was observed with topical lidocaine group when compared with the ice application group (p < 0." | 9.20 | A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings. ( Aksel, G; Çorbacioğlu, ŞK; Doğan, NÖ; Güler, S, 2015) |
| "To evaluate the efficacy and safety profile of paracetamol in comparison with tramadol for pain relief during active labor." | 9.20 | Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor. ( Bhatia, N; Jain, K; Jain, V; Kaur Makkar, J; Mal Mithrawal, S, 2015) |
| "To test the analgesic efficacy of oxymorphone hydrochloride (OH) and propoxyphene/acetaminophen (PA) for patients with neurogenic claudication associated with lumbar spinal stenosis." | 9.20 | A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis. ( Chowdhry, AK; Dworkin, RH; Frazer, ME; Gewandter, JS; Markman, JD; McDermott, MP; Murray, NM; Pilcher, WH; Rast, SA; Tomkinson, EJ; Walter, KA, 2015) |
| "Acetaminophen, an effective and popular over-the-counter pain reliever (e." | 9.20 | Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli. ( Durso, GR; Luttrell, A; Way, BM, 2015) |
| "This study aims to evaluate and compare the effect of pre-procedural administration of acetaminophen, ibuprofen, and meloxicam in reducing pain after separator placement." | 9.20 | Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. ( Babanouri, N; Oshagh, M; Salehi, P; Torkan, S; Zarif Najafi, H, 2015) |
| "The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used." | 9.20 | Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015) |
| "9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0." | 9.19 | Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014) |
| "A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair." | 9.19 | Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014) |
| "This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)." | 9.19 | Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. ( Bijur, PE; Chang, AK; John Gallagher, E; Munjal, KG, 2014) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 9.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| "Rocuronium is a nondepolarizing neuromuscular blocking agent used in anesthesia induction and is associated with considerable discomfort and burning pain during injection, which is reported to occur in 50-80% of patients." | 9.19 | The effect of intravenous paracetamol for the prevention of rocuronium injection pain. ( Aypar, U; Canbay, O; Erden, IA; Uzun, S, 2014) |
| " We explore whether the neural mechanism that responds to meaning threats can be inhibited by acetaminophen, in the same way that acetaminophen inhibits physical pain or the distress caused by social rejection." | 9.17 | The common pain of surrealism and death: acetaminophen reduces compensatory affirmation following meaning threats. ( Heine, SJ; Randles, D; Santos, N, 2013) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 9.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| "Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing." | 9.16 | Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| "5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) with that of nonsteroidal anti-inflammatory drugs (NSAIDs) as maintenance therapy following tramadol/APAP and NSAID combination therapy in knee osteoarthritis (OA) pain which was inadequately controlled by NSAIDs." | 9.16 | The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). ( Cho, CS; Choi, JJ; Kim, WU; Min, JK; Park, KS; Park, SH, 2012) |
| "The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease." | 9.15 | Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients. ( Kang, P; Li, J; Liu, G; Liu, W; Luo, R; Ma, X; Pei, F; Shen, B; Xie, Q; Zhou, Z, 2011) |
| "We tested whether paracetamol could improve pain relief in patients visiting the emergency department with acute renal colic as compared to piroxicam, a nonsteroidal anti-inflammatory drug (NSAID)." | 9.15 | Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial. ( Boubaker, H; Boudhib, L; Bouida, W; Boukef, R; Claessens, YE; Grissa, MH; Kerkeni, W; Nouira, S, 2011) |
| "To evaluate the efficacy and safety of the paracetamol-tramadol combination (PTC) in treating moderate-to-severe pain, in patients aged 65 years and over within general practitioner (GP) practice centers." | 9.15 | Epidemiological data, efficacy and safety of a paracetamol-tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practice. ( Ganry, H; Mejjad, O; Serrie, A, 2011) |
| " The effects of acetaminophen, tropisetron, the combination of both drugs, and saline on pain perception and central sensitization in healthy volunteers were compared." | 9.15 | Tropisetron blocks analgesic action of acetaminophen: a human pain model study. ( Bandschapp, O; Filitz, J; Koppert, W; Ruppen, W; Urwyler, A, 2011) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 9.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care." | 9.15 | A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011) |
| "The present study aimed to examine the effectiveness of intravenous administration of paracetamol added to morphine in the control of cancer pain and its possible contribution as reduction of opioid consumption and opioid-related side effects." | 9.14 | Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control. ( Aydinli, I; Keskinbora, K; Pekel, AF; Salihoglu, T; Sonsuz, A; Tasmacioglu, B, 2009) |
| "This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee." | 9.14 | Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa ( Berggren, AC; Karlsson, M, 2009) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 9.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting." | 9.14 | Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. ( Friday, JH; Harley, JR; Kanegaye, JT; McCaslin, I; Zheng, A, 2009) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | 9.14 | A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| "5 mg kg(-1) for prevention of propofol induced pain." | 9.14 | Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol. ( Borazan, H; Erdem, TB; Kececioglu, M; Otelcioglu, S, 2010) |
| "This study suggests that paracetamol, lornoxicam, and tramadol can be safely and efficiently preferred in pain control during SWL." | 9.14 | Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol representing three different groups of analgesics for pain control in extracorporeal shockwave lithotripsy. ( Akcali, GE; Balcioglu, YO; Cam, K; Demiraran, Y; Iskender, A; Kayikci, A; Yalcin, GS, 2010) |
| "To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain." | 9.14 | Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010) |
| "This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy." | 9.14 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010) |
| " They were randomized to receive ibuprofen or paracetamol when pain relief was necessary." | 9.14 | Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study. ( David, LB; Livshits, A; Machtinger, R; Moshe-Zahav, A; Seidman, DS; Spira, M, 2009) |
| " Aim of this study was to examine the analgesic and antihyperalgesic properties of the weak opioid tramadol and the non-opioid acetaminophen, alone as well as in combination, in an experimental pain model in humans." | 9.13 | Supra-additive effects of tramadol and acetaminophen in a human pain model. ( Filitz, J; Günther, W; Ihmsen, H; Koppert, W; Schüttler, J; Schwilden, H; Tröster, A, 2008) |
| " acetaminophen seems to be effective in attenuating pain during i." | 9.13 | Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain. ( Arun, O; Canbay, O; Celebi, N; Karagöz, AH; Ozgen, S; Saricaoğlu, F, 2008) |
| "To examine, in routine practice, the effectiveness and cost-effectiveness of oxycodone (OxyContin) compared with standard therapy for osteoarthritis pain." | 9.12 | Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee. ( Buitendyk, M; Codding, C; Marshall, DA; Pericak, D; Strauss, ME; Torrance, GW, 2006) |
| "In this double-blind cross-over study, we assessed whether erythromycin infusion is effective as a prokinetic drug against gastroparesis from acute pain." | 9.12 | Erythromycin promotes gastric emptying during acute pain in volunteers. ( Allaouchiche, B; Bleyzac, N; Boselli, E; Bouvet, L; Chassard, D; Duflo, F; Mion, F, 2006) |
| "Administering 75 mg tramadol/650 mg acetaminophen orally with periprostatic 1% lidocaine before transrectal ultrasound guided prostate biopsy is a safe, easy and effective method of controlling pain during the biopsy procedure." | 9.12 | Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial. ( Carvin, DM; Costa, J; Pendleton, J; Rosser, CJ; Wludyka, P, 2006) |
| "The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC)." | 9.12 | Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. ( Bey, M; Burnett, I; Grattan, T; Littlejohn, S; Sanner, K; Schachtel, B, 2006) |
| "0001) and was superior to pseudoephedrine and placebo for pain relief (p < or = 0." | 9.12 | Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. ( Burnett, I; Eccles, R; Jawad, M; Jawad, S; Jones, E; North, M; Ridge, D, 2006) |
| "5-mg/acetaminophen 325-mg combination tablets (tramadoUAPAP) as add-on therapy in subjects with rheumatoid arthritis (RA) pain that was inadequately controlled by NSAIDs and disease-modifying antirheumatic drugs alone." | 9.12 | Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial. ( Baek, HJ; Kim, HA; Lee, CK; Lee, EB; Lee, EY; Lim, MK; Park, BJ; Seo, YI; Sheen, DH; Shim, SC; Song, YW; Yoo, B, 2006) |
| "Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries." | 9.12 | A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007) |
| "Combined tramadol/acetaminophen is used to treat pain related to osteoarthritis." | 9.12 | A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain. ( Bae, SC; Choe, JY; Choi, CB; Chung, WT; Hong, YH; Ji, JD; Kang, YM; Kim, HA; Kim, TH; Lee, CK; Lee, J; Lee, JT; Lim, MK; Nam, EJ; Park, SH; Seo, YI; Sheen, DH; Shim, SC; Song, GG; Song, JS; Suh, CH; Sung, YK, 2007) |
| "This study compared the efficacy and safety profile of buprenorphine transdermal delivery system (BTDS) and placebo in subjects with persistent noncancer-related pain who required opioid analgesics." | 9.12 | Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study. ( Carr, WD; Landau, CJ; Munera, C; Razzetti, AJ; Ripa, SR; Sessler, NE, 2007) |
| "It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries." | 9.12 | The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium. ( Agus, H; Kayali, C; Surer, L; Turgut, A, 2007) |
| "5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)." | 9.11 | Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004) |
| "5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients." | 9.11 | Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004) |
| "To compare the effects of providing analgesia with either transdermal fentanyl (TTS-fentanyl) or paracetamol and codeine (P/C) in addition to radiotherapy in patients with metastatic bone pain." | 9.11 | Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. ( Eleftheriadis, N; Georgakopoulos, G; Gompakis, N; Kouloulias, VE; Kouvaris, J; Mystakidou, K; Pistevou-Gompaki, K; Varveris, C, 2004) |
| "In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of >or= 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (singledose phase) followed by 5/325 mg every 6h as needed (multidose phase), or placebo." | 9.11 | Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. ( Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA, 2004) |
| "To determine in a sample of nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of acetaminophen in reducing discomfort." | 9.11 | A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia. ( Brod, M; Buffum, MD; Miaskowski, C; Sands, L; Washburn, A, 2004) |
| "To determine whether adding regular acetaminophen (paracetamol) could improve pain and well-being in people with advanced cancer and pain despite strong opioids." | 9.11 | Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial. ( Pillai, A; Stockler, M; Vardy, J; Warr, D, 2004) |
| "It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of nasal congestion associated with the common cold." | 9.11 | Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold. ( Loose, I; Winkel, M, 2004) |
| "To compare the safety and efficacy of a new cyclooxygenase-2 inhibitor, valdecoxib, with those of an oxycodone-acetaminophen combination in patients with acute musculoskeletal pain." | 9.11 | Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. ( Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A, 2004) |
| "To compare efficacy and safety of strepfen (flurbiprofen) to those of oral paracetamol in acute infections of the upper respiratory tracts for relief of throat pain (TP)." | 9.11 | [Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain]. ( Balandin, AV; Dimova, AD; Sedinkin, AA, 2005) |
| "The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea." | 9.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815)." | 9.10 | Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. ( Cairns, R; Le Parc, JM; Moore, N; Schneid, H; van Ganse, E; Wall, R, 2002) |
| "5 mg tramadol/325 mg acetaminophen) for the treatment of fibromyalgia pain." | 9.10 | Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study. ( Bennett, RM; Kamin, M; Karim, R; Rosenthal, N, 2003) |
| "The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain." | 9.10 | Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002) |
| "Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol." | 9.09 | Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol. ( Bhagat, K; Lala, I; Leech, P; Montgomery, L, 2000) |
| "To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain." | 9.09 | Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999) |
| "This randomized, double-blind, placebo-controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg--an effervescent solution and tablet--in 242 patients with moderate or severe pain following dental surgery." | 9.09 | Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. ( Ganry, HE; Insuasty, JH; Møller, PL; Nørholt, SE; Sindet-Pedersen, S; Skoglund, LA; Vincent, FG, 2000) |
| "5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain." | 9.09 | Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000) |
| "To determine whether greater pain intensity at initiation of treatment predicted better response to ibuprofen than to acetaminophen in subjects with knee osteoarthritis (OA)." | 9.09 | Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001) |
| "Opioid/acetaminophen (APAP) combination analgesics are widely prescribed for the relief of moderate pain." | 9.09 | Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. ( Lacy, JR; Mullican, WS, 2001) |
| "Ibuprofen and acetaminophen with codeine had similar analgesic properties in the first 24 hours post partum (mean pain rating 3." | 9.09 | Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. ( Douglas, MJ; Grange, CS; Janssen, PA; Peter, EA, 2001) |
| "The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia." | 9.08 | Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998) |
| "To evaluate the efficacy of an oral tramadol preparation versus that of an oral hydrocodone-acetaminophen preparation in acute musculoskeletal pain." | 9.08 | Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. ( Larkin, GL; Paris, PM; Turturro, MA, 1998) |
| "Recognizing the concerns about the use of local anesthesia in neonatal circumcision, a painful procedure usually performed without analgesia or anesthesia, we undertook a study of acetaminophen for pain management of this procedure." | 9.07 | Acetaminophen analgesia in neonatal circumcision: the effect on pain. ( Howard, CR; Howard, FM; Weitzman, ML, 1994) |
| "In a double-blind study of 18 patients with coxarthrosis the effect of 3 naproxen doses (0." | 9.07 | Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients. ( Neander, G; Samuelson, P; Seideman, P, 1993) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 9.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers." | 9.07 | Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity. ( Bromm, B; Forth, W; Richter, E; Scharein, E, 1992) |
| "In a randomized, double-blind prospective manner, patients received either 5 mg hydrocodone with 500 mg acetaminophen or 30 mg codeine with 500 mg acetaminophen to take on discharge from the ED and every four hours thereafter as needed for pain." | 9.07 | Hydrocodone versus codeine in acute musculoskeletal pain. ( Menegazzi, JJ; Paris, PM; Turturro, MA; Yealy, DM, 1991) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 9.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip." | 9.06 | Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990) |
| "Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control." | 9.06 | The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988) |
| "We compared naproxen sodium (550 mg) and propoxyphene napsylate with acetaminophen (PN/A, 100 mg with 650 mg) for pain relief after arthroscopy or arthroscopic meniscectomy." | 9.06 | Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen. ( Drez, D; Ritter, M; Rosenberg, TD, 1987) |
| "To test the hypothesis that the postoperative abdominal pain of tubal occlusion is mediated by prostaglandins, the effects of meclofenamate, a potent inhibitor of cyclooxygenase, on postoperative analgesia and incidence of abdominal pain were compared with those of acetaminophen, a weak inhibitor of prostaglandin activity." | 9.06 | Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion. ( Caissie, KF; Huang, KC; Simpson, PM; Tsueda, K; Wolfe, WM, 1986) |
| "Fifty college athletes with acute sprains and strains from football-related activities were randomly assigned to treatment with either diflunisal or acetaminophen with codeine for seven days." | 9.06 | Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. ( Indelicato, PA, 1986) |
| "Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children." | 9.05 | Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 9.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "The efficacy and acceptability of meptazinol and dextropropoxyphene plus paracetamol were compared in 32 elderly patients with various types of musculoskeletal pain." | 9.05 | A comparison between meptazinol and dextropropoxyphene plus paracetamol in elderly patients with musculoskeletal pains. ( Orö, L, 1984) |
| "In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)." | 9.05 | A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984) |
| "A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo." | 9.05 | A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982) |
| "The objectives of this review were to assess the ability of both pharmacological and non-pharmacological interventions to reduce or eliminate the pain that accompanies rocuronium bromide administration." | 8.93 | Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. ( Ali, Z; Kalaivani, M; Prabhakar, H; Singh, GP; Smith, MA, 2016) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 8.93 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016) |
| "To determine the efficacy and safety of codeine used alone or in combination with paracetamol for relieving cancer pain." | 8.90 | Codeine, alone and with paracetamol (acetaminophen), for cancer pain. ( Bell, RF; Derry, S; Jackson, KC; Strassels, S; Straube, C; Straube, S; Wiffen, PJ, 2014) |
| "Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain." | 8.89 | Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013) |
| "Acetaminophen/codeine combination is effective in the treatment of moderate to severe pain in all setting analyzed in this study, which include headache, postoperative, osteoarticular and post-traumatic." | 8.89 | Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin. ( Alesi, A; Antonini, EF; Cordischi, C; Franceschi, F; Giacobelli, D; Iacomini, P; Marsiliani, D; Zuccalà, G, 2013) |
| "To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness." | 8.88 | Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012) |
| "To systematically review the literature on the safety of using nonsteroidal antiinflammatory drugs (NSAID) and/or paracetamol in people receiving methotrexate (MTX) for inflammatory arthritis (IA), as an evidence base for generating clinical practice recommendations." | 8.88 | Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review. ( Colebatch, AN; Edwards, CJ; Marks, JL; van der Heijde, DM, 2012) |
| "Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited." | 8.87 | Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011) |
| "Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain." | 8.86 | Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010) |
| "Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage." | 8.84 | Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007) |
| "To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever." | 8.82 | Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004) |
| "To assess the efficiency of paracetamol, indicated in first instance for light-to-moderate pain from hip and knee arthrosis, against rofecoxib, the COX-2 inhibitor most commonly used in Spain." | 8.82 | [Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip]. ( Lizán Tudela, L; Magaz Marqués, S; Riesgo Bucher, Y; Varela Moreno, C, 2004) |
| "The treatment of acute or chronic pain of variable intensity and origin, is efficiently achieved by the association of paracetamol and codeine." | 8.81 | [Efficacy and safety of acetaminophen-codeine in the treatment of pain]. ( Hantson, P, 2002) |
| "In order to assess the analgesia obtained from single oral doses of paracetamol alone and in combination with codeine in postoperative pain, we conducted a systematic review of randomised controlled trials." | 8.79 | Paracetamol with and without codeine in acute pain: a quantitative systematic review. ( Carroll, D; Collins, S; McQuay, H; Moore, A, 1997) |
| "Overall, 74% of women reported acetaminophen use during pregnancy." | 8.12 | Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes. ( Bandoli, G; Chambers, C; Killion, JA; Smith, CJF, 2022) |
| "The inclusion of IV acetaminophen as part of a multimodal pain regimen led to fewer episodes of delirium in this study." | 7.96 | Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients. ( Connolly, KP; Kleinman, RS; Mehta, SN; Neuman, MD; Stevenson, KL, 2020) |
| "Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy." | 7.96 | Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. ( Bandoli, G; Chambers, C; Palmsten, K, 2020) |
| "Paclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment." | 7.96 | Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats. ( Brusco, I; Ferreira, J; Hausen, BDS; Moresco, RN; Oliveira, SM; Pinheiro, KV; Rigo, FK, 2020) |
| "Data of patients treated with a combination of oxycodone (5, 10, and 20 mg) and acetaminophen (325 mg) were evaluated for gender, current disease condition, basal pain intensity, total daily dose, days of controlled pain at the initial low dose, and pain intensity after treatment using a numeric pain rating scale." | 7.83 | Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better. ( Carpenedo, R; Dauri, M; Lazzari, M; Mammucari, M; Natoli, S; Palombo, E; Silvi, MB, 2016) |
| "Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking." | 7.80 | Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014) |
| " Tramadol/acetaminophen medication was effective in reducing pain in seven of nine cases(77." | 7.79 | [Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. ( Hirano, M; Kajita, Y; Nakahara, N; Noda, H; Takebayashi, S; Tanei, T; Wakabayashi, T, 2013) |
| "Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval." | 7.78 | Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012) |
| "This is a pharmacokinetic study of 30 postpartum women receiving hydrocodone bitartrate for postpartum pain in the inpatient setting." | 7.77 | Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. ( Anderson, PO; Lane, JR; Nguyen, N; Rafie, S; Rossi, SS; Sauberan, JB; Stellwagen, LM, 2011) |
| "We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period." | 7.77 | Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 7.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| "5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients." | 7.76 | Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients. ( Chang, CS; Chung, CY; Ho, ML; Hsu, NC; Lin, HY; Wang, CC, 2010) |
| "The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)." | 7.74 | Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007) |
| "Morphine and other opioids are the mainstay of cancer pain management, yet considerable fears surrounding them present barriers to pain control." | 7.74 | Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. ( Gooberman-Hill, R; Hanks, GW; Reid, CM, 2008) |
| "Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain." | 7.73 | Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain. ( Aoe, T; Saito, O; Yamamoto, T, 2005) |
| "To determine whether multiple dosing of acetaminophen would result in drug accumulation in polymedicated elderly patients with rheumatic pain." | 7.71 | Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain. ( Bannwarth, B; Lagrange, F; Le Bars, M; Matoga, M; Maury, S; Palisson, M; Pehourcq, F, 2001) |
| "(1) This codeine-based syrup is indicated for the treatment of pain in children." | 7.70 | Codeine for child pain: new preparation. Helpful in some cases. ( , 1999) |
| "This retrospective review evaluated the pain management of 395 acutely burned pediatric patients who were treated by a pain management protocol emphasizing acetaminophen as the initial medication to control background pain." | 7.69 | Acetaminophen in the management of background pain in children post-burn. ( Blakeney, PE; Cortiella, J; Herndon, DN; Marvin, JA; Meyer, WJ; Nichols, RJ; Villarreal, C, 1997) |
| " A case of NAS due to codeine prescribed for pain relief during pregnancy is reported." | 7.69 | Neonatal abstinence syndrome due to codeine. ( Chang, J; Khan, K, 1997) |
| "The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat." | 7.68 | Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993) |
| "A comparison was made between the relative effects of aspirin, mefenamic acid, dihydrocodeine , dextropropoxyphene and paracetamol on visceral pain (chemically-inducing writhing), respiratory rate and prostaglandin (PG) biosynthesis (cyclo-oxygenase activity)." | 7.67 | Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis. ( Gonzalez, JP; Pugh, J; Sewell, RD, 1984) |
| "We studied the effects of two non-steroidal anti-inflammatory analgesics (NSAIAs), acetylsalicylic acid (ASA) and acetaminophen, on sleep patterns in rats with adjuvant-induced arthritis." | 7.67 | Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989) |
| "The effectiveness of nonprescription analgesics--acetaminophen and aspirin--in providing subjective relief of preoperative dental pain was evaluated in a varied population of adults." | 7.66 | Evaluation of acetaminophen and aspirin in the relief of preoperative dental pain. ( Kilkuts, A; Korberly, BH; Orkand, RK; Schreiber, GF; Segal, H, 1980) |
| "The pain was scored through a 100-mm visual analog scale (VAS) immediately and 2 h after the procedure." | 6.82 | Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial. ( Abbasi, M; Agah, E; Ahmadi, M; Faghihi-Kashani, S; Kalantar, SS; Majedi, H; Tafakhori, A, 2016) |
| "Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery." | 6.82 | Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels. ( Eberhardt, E; Eberhardt, M; Leffler, A; Schillers, F, 2016) |
| "Acetaminophen (APAP) is a popular analgesic." | 6.73 | Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain. ( Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007) |
| "Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention." | 6.72 | Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. ( Brandt, KD; Buckwalter, KA; Mazzuca, SA, 2006) |
| "Naproxen and ibuprofen were more effective than acetaminophen in minimizing physical side effects of IFN beta-1a." | 6.71 | A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. ( Filipi, M; Healey, K; Leuschen, MP, 2004) |
| " Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited." | 6.71 | Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005) |
| "Pain was related to an infection in 98% of the cases." | 6.70 | [Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol]. ( Bernard-Fernier, MF; Cabane, J, 2001) |
| "CR codeine treatment resulted in significantly lower overall VAS pain intensity scores (35 +/- 18 vs." | 6.68 | Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial. ( Arkinstall, W; Babul, N; Darke, AC; Goughnour, B; Harsanyi, Z; Sandler, A, 1995) |
| "Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine." | 6.66 | Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986) |
| " Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months." | 6.64 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974) |
| "His pain was scored as a five on a six-point visual analog scale, and it persisted despite routine supportive therapy." | 6.50 | [A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl]. ( Anzai, S; Hashimoto, Y; Nagasawa, K; Suzuki, T, 2014) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 6.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| "Acetaminophen is a safe medication that should be considered first-line therapy." | 6.44 | Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? ( Choquette, D; Craig, BN; Davis, P; De Angelis, C; Fulthorpe, G; Habal, F; Hunt, RH; Stewart, JI; Turpie, AG, 2007) |
| "Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events." | 6.43 | Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005) |
| "Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day." | 6.42 | Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004) |
| " In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury." | 6.41 | Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| " Antinociception was assessed by dose-response curves to paracetamol and meloxicam before and after the i." | 5.72 | Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2022) |
| " Acetaminophen, the active ingredient found in Tylenol, is among the most common pain medications consumed." | 5.69 | Acetaminophen changes Mu rhythm power related to pain empathy. ( Jelsone-Swain, L; McCommon, SA; Roach, A; Turk, B, 2023) |
| "This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)." | 5.51 | The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022) |
| "We aimed to characterize the current pain experience of patients completing an evidence-based mifepristone-misoprostol medication abortion regimen using real-time pain scores." | 5.51 | The experience of pain in real-time during medication abortion. ( Davis, J; Fontanilla, T; Friedlander, EB; Horiuchi, W; Kaneshiro, B; Raidoo, S; Salcedo, J; Soon, R; Tschann, M, 2022) |
| "This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM." | 5.51 | The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022) |
| "Over a 12-month evaluation period, verbal numerical pain scores (VNPS) were gathered from adults with moderate to severe trauma pain attended by ambulance staff trained in administering and supplied with methoxyflurane." | 5.51 | Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study. ( Rowan, E; Siriwardena, AN; Smith, MD; Spaight, R, 2022) |
| "Intranasal fentanyl seems to be a safe and effective alternative to acetaminophen with hydrocodone in reducing pain and improving hydration status in children with painful infectious mouth lesions and poor oral intake." | 5.51 | Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions. ( Chen, JG; Cramm, K; Florez, C; Papa, L; Ramirez, J; Ruffin, TB; Salinero, E, 2022) |
| " The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography." | 5.51 | Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022) |
| " Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo." | 5.51 | Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study. ( Aktaş, N; Arslan, E; Aydın, İ; Gülaçtı, U; Sönmez, C; Turgut, K; Yavuz, E, 2022) |
| " IV and PO APAP doses administered with a predose pain score ≥4 within 1 h of dosing were compared." | 5.43 | Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. ( Brophy, GM; Nadpara, PA; Nichols, DC; Taylor, PD, 2016) |
| "Acetaminophen is a frequently used analgesic for pain and fever." | 5.41 | In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis. ( Albanese, CM; Barrett, K; Brown, HK; Fatima, M; Levis, B; Li, J; Pablo, LA; Ricci, C, 2023) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 5.41 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023) |
| "The study aimed to compare the acetaminophen administration efficacy or its combination with codeine for pain control in acute apical abscesses cases." | 5.41 | Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial. ( Cardoso, MBF; da Rosa, RA; da Silva, PB; do Nascimento, AL; Mendes, AT; Pereira, JR; Só, MVR, 2021) |
| " The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)." | 5.41 | Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 5.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "Acetaminophen is an analgesic and antipyretic drug believed to exert its effect through interruption of nociceptive processing." | 5.35 | Acetaminophen prevents hyperalgesia in central pain cascade. ( Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL, 2008) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline." | 5.35 | Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008) |
| " Lidocaine given intravenously has been shown in two small, uncontrolled studies to have an appreciable effect on pain after burns." | 5.34 | Lidocaine infusion has a 25% opioid-sparing effect on background pain after burns: A prospective, randomised, double-blind, controlled trial. ( Abdelrahman, I; Elmasry, M; Sjoberg, F; Steinvall, I, 2020) |
| "The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial." | 5.34 | Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020) |
| "The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of persons with dementia living in long-term care facilities (LTCFs)." | 5.34 | Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial. ( Achterberg, WP; Caljouw, MAA; Husebo, BS; van Dam, PH, 2020) |
| "He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated." | 5.34 | Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007) |
| "Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase." | 5.33 | Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice. ( Choi, SS; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW, 2005) |
| "To evaluate the effectiveness of verbal behavior modification, acetaminophen, and the combined effectiveness of verbal behavior modification along with acetaminophen on orthodontic pain." | 5.30 | A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. ( Abraham, R; Bansal, N; Kaur, H, 2019) |
| "We addressed these issues by investigating how acetaminophen administration and daily forgiveness are associated with experiences of social pain over 21 days." | 5.30 | Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen. ( Deal, BD; Gregory, A; Shields, GS; Slavich, GM; Toussaint, LL, 2019) |
| " Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups." | 5.30 | Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. ( Azami, A; Enteshari-Moghaddam, A; Habibzadeh, A; Isazadehfar, K; Jahanpanah, P; Mohebbi, H, 2019) |
| "To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection." | 5.30 | Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. ( Jongjidpranitarn, M; Nimmaanrat, S; Oofuvong, M; Prathep, S, 2019) |
| " Patients received stepwise pain treatment in which those who did not use analgesics were randomized to receive either paracetamol (3 g/day) or placebo tablets; those who already used pain treatment were allocated to buprenorphine transdermal system (max." | 5.27 | Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial. ( Bjorvatn, B; Blytt, KM; Flo, E; Husebo, B, 2018) |
| "There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED." | 5.27 | Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. ( Cattermole, GN; Graham, CA; Hung, KKC; Leung, LY; Leung, YK; Lo, RSL; Man, SY; Rainer, TH; Woo, WK, 2018) |
| "The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features." | 5.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department." | 5.27 | Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018) |
| " As part of an ongoing research program, we examined the effects of a commonly prescribed combination of medications for pain relief: alprazolam, a benzodiazepine, and a hydrocodone preparation, a combination opiate and acetaminophen, on a simulated driving protocol." | 5.27 | Evaluating drugged driving: Effects of exemplar pain and anxiety medications. ( Brown, TL; Gaffney, G; Milavetz, G; Spurgin, A, 2018) |
| "This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery." | 5.27 | Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. ( de Kam, ML; Groeneveld, GJ; Hay, JL; Siebenga, P; van Amerongen, G, 2018) |
| "The effects of acetaminophen and a reading task on physical pain tolerance and fearlessness about death were tested in 106 undergraduate students." | 5.27 | The Influence of Acetaminophen and Observational Conditioning on the Acquired Capability for Suicide. ( Chiurliza, B; Joiner, TE, 2018) |
| "An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain." | 5.24 | Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. ( Doherty, M; Hussain, S; McWilliams, D; Papou, A; Zhang, W, 2017) |
| " All studies analysed support that toxicity is not reached; and that acetaminophen provides a morphine sparing effect without adverse effects." | 5.22 | The efficacy and safety of acetaminophen use following liver resection: a systematic review. ( Koea, J; Murphy, V; Srinivasa, S, 2022) |
| "Buprenorphine formulations (including buprenorphine/naloxone) are effective treatments of pain and opioid use disorder (OUD)." | 5.22 | Perioperative Buprenorphine Management: A Multidisciplinary Approach. ( Abelleira, A; Acampora, G; Becker, WC; Falker, CG; Hickey, T; Nazario, M; Weimer, MB, 2022) |
| " Only one study found evidence of an effect between interventions on pain score: a prophylactic dose of ibuprofen 1600 mg likely reduces the pain score when compared to a dose of paracetamol 2000 mg (mean difference (MD) 2." | 5.22 | Pain management for medical abortion before 14 weeks' gestation. ( Cameron, S; Morroni, C; Reynolds-Wright, JJ; Woldetsadik, MA, 2022) |
| " Further research is required to determine whether the use of nitrous oxide has a role, and to develop a safe and effective analgesic strategy to fully ameliorate the pain of ROP screening." | 5.22 | Analgesia for retinopathy of prematurity screening: A systematic review. ( Hamilton, DL; Hassan, R; Savant, SV; Thirunavukarasu, AJ, 2022) |
| "Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants." | 5.22 | Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. ( FitzGerald, GA; Grosser, T; Spence, JD, 2022) |
| "HNC patients (pts) receiving CRT were randomized to standard pain control (SPC) with acetaminophen and opioids, or SPC plus gabapentin (SPC+G)." | 5.22 | Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer. ( Chayahara, N; Fujiwara, Y; Funakoshi, Y; Kataoka, T; Kiyota, N; Komori, T; Minami, H; Mukohara, T; Nibu, K; Sasaki, R; Shimada, T; Toyoda, M, 2016) |
| "The combination of ibuprofen/paracetamol, taken immediately after initial endodontic therapy and root canal preparation in teeth with irreversible pulpitis, reduced post-endodontic pain (ClinicalTrials." | 5.22 | Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. ( Abubakr, NH; Elzaki, WM; Ibrahim, YE; Ziada, HM, 2016) |
| "The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator." | 5.22 | Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial. ( Ghadirian, H; Hosseinzadeh Nik, T; Ostad, SN; Shahsavari, N, 2016) |
| "Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking." | 5.22 | Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016) |
| "Although liposomal bupivacaine had some effect on soft tissue anesthesia, it did not reduce pain to manageable clinical levels in patients presenting with untreated, symptomatic irreversible pulpitis." | 5.22 | Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( Beck, M; Bultema, K; Drum, M; Fowler, S; Nusstein, J; Reader, A, 2016) |
| " Significant reduction in pain intensity was observed with topical lidocaine group when compared with the ice application group (p < 0." | 5.20 | A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings. ( Aksel, G; Çorbacioğlu, ŞK; Doğan, NÖ; Güler, S, 2015) |
| "To evaluate the efficacy and safety profile of paracetamol in comparison with tramadol for pain relief during active labor." | 5.20 | Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor. ( Bhatia, N; Jain, K; Jain, V; Kaur Makkar, J; Mal Mithrawal, S, 2015) |
| "To test the analgesic efficacy of oxymorphone hydrochloride (OH) and propoxyphene/acetaminophen (PA) for patients with neurogenic claudication associated with lumbar spinal stenosis." | 5.20 | A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis. ( Chowdhry, AK; Dworkin, RH; Frazer, ME; Gewandter, JS; Markman, JD; McDermott, MP; Murray, NM; Pilcher, WH; Rast, SA; Tomkinson, EJ; Walter, KA, 2015) |
| "Acetaminophen, an effective and popular over-the-counter pain reliever (e." | 5.20 | Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli. ( Durso, GR; Luttrell, A; Way, BM, 2015) |
| "This study aims to evaluate and compare the effect of pre-procedural administration of acetaminophen, ibuprofen, and meloxicam in reducing pain after separator placement." | 5.20 | Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. ( Babanouri, N; Oshagh, M; Salehi, P; Torkan, S; Zarif Najafi, H, 2015) |
| "This randomized, double-blind study enrolled patients ≥40 years of age with confirmed hip or knee OA (Kellgren-Lawrence grade II-III) who were chronic users of NSAIDs and/or acetaminophen for OA pain and had Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale mean scores ≥40 mm." | 5.20 | Efficacy and safety of low-dose SoluMatrix meloxicam in the treatment of osteoarthritis pain: a 12-week, phase 3 study. ( Altman, R; Gibofsky, A; Hochberg, M; Jaros, M; Young, C, 2015) |
| "The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used." | 5.20 | Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015) |
| " According to a predefined scheme for 8 weeks, all patients in the intervention group received individual daily pain treatment with acetaminophen, extended release morphine, buprenorphine transdermal patch, and/or pregabaline." | 5.19 | The response of agitated behavior to pain management in persons with dementia. ( Aarsland, D; Ballard, C; Cohen-Mansfield, J; Husebo, BS; Seifert, R, 2014) |
| "The aim of this double-blind, randomized, placebo-controlled clinical study was to evaluate the analgesic effects of preoperative/postoperative ibuprofen and acetaminophen use after bonding and to find a relation between the pain level and the amount of prostaglandin released." | 5.19 | Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement. ( Bostanoglu, E; Demirbilek, M; Polat-Ozsoy, O; Tunçer, Z, 2014) |
| "9%) patients in acetaminophen/oxycodone group experienced nausea that was statistically significant higher (P value = 0." | 5.19 | Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014) |
| "A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair." | 5.19 | Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014) |
| "This was a prospective, randomized, double-blind, clinical trial of patients with acute extremity pain who were discharged home from the ED, comparing a 3-day supply of oral hydrocodone/acetaminophen (5 mg/500 mg) to oral codeine/acetaminophen (30 mg/300 mg)." | 5.19 | Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. ( Bijur, PE; Chang, AK; John Gallagher, E; Munjal, KG, 2014) |
| "This study aimed to evaluate whether combined oral oxycodone hydrochloride-controlled release tablets plus paracetamol and tramadol hydrochloride tablets are more effective than epidural analgesia for postoperative pain control and side effects after cesarean section." | 5.19 | A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia. ( Konstantatos, A; Liu, Q; Wang, HW; Zhao, JN; Zhong, TD, 2014) |
| " In a randomized controlled trial, we evaluated whether oral acetaminophen or ibuprofen reduced the pain experienced during pin removal." | 5.19 | Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial. ( Abdullah, SN; Allen, JC; Lim, KB; Ong, LL; Tan, SS; Wong, ML, 2014) |
| "Pain medication significantly improved pain in the intervention group, with indications that acetaminophen also improved ADL function." | 5.19 | Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014) |
| "Administration of 1 g paracetamol and 600 mg ibuprofen one hour prior to office hysteroscopy decreased statistically the occurrence of non-pain side effects such as nausea, emesis, and hypotension." | 5.19 | Evaluation of pain in office hysteroscopy with prior analgesic medication: a prospective randomized study. ( De Santiago, J; Teran-Alonso, MJ; Usandizaga, R; Zapardiel, I, 2014) |
| "Acetaminophen (APAP) by oral or intravenous (iv) routes is used for mild to moderate pain but may take time to be effective." | 5.19 | Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers. ( Cardot, JM; Coissard, S; Dubray, C; Libert, F; Macian, N; Maury, M; Perovitch, P; Pickering, G, 2014) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 5.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| "Rocuronium is a nondepolarizing neuromuscular blocking agent used in anesthesia induction and is associated with considerable discomfort and burning pain during injection, which is reported to occur in 50-80% of patients." | 5.19 | The effect of intravenous paracetamol for the prevention of rocuronium injection pain. ( Aypar, U; Canbay, O; Erden, IA; Uzun, S, 2014) |
| " We explore whether the neural mechanism that responds to meaning threats can be inhibited by acetaminophen, in the same way that acetaminophen inhibits physical pain or the distress caused by social rejection." | 5.17 | The common pain of surrealism and death: acetaminophen reduces compensatory affirmation following meaning threats. ( Heine, SJ; Randles, D; Santos, N, 2013) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 5.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| "Previous studies suggest that the antinociceptive action of paracetamol (acetaminophen, APAP) might involve descending inhibitory pain pathways and the opioidergic system: this study explores this issue in humans with naloxone, the opioid antagonist." | 5.17 | Paracetamol and opioid pathways: a pilot randomized clinical trial. ( Cardot, JM; Desbrandes, S; Dubray, C; Moustafa, F; Pickering, G; Roux, D, 2013) |
| "To assess the efficacy of paracetamol (acetaminophen) for neonatal pain relief." | 5.17 | Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response. ( Bucher, HU; Bührer, C; Burkhardt, T; Hoesli, I; Jost, K; Krafft, A; Nelle, M; Schöbi, N; Surbek, D; Tinner, EM; Ulrich Megged, Y, 2013) |
| "Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing." | 5.16 | Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| "5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) with that of nonsteroidal anti-inflammatory drugs (NSAIDs) as maintenance therapy following tramadol/APAP and NSAID combination therapy in knee osteoarthritis (OA) pain which was inadequately controlled by NSAIDs." | 5.16 | The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). ( Cho, CS; Choi, JJ; Kim, WU; Min, JK; Park, KS; Park, SH, 2012) |
| "The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease." | 5.15 | Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients. ( Kang, P; Li, J; Liu, G; Liu, W; Luo, R; Ma, X; Pei, F; Shen, B; Xie, Q; Zhou, Z, 2011) |
| "We tested whether paracetamol could improve pain relief in patients visiting the emergency department with acute renal colic as compared to piroxicam, a nonsteroidal anti-inflammatory drug (NSAID)." | 5.15 | Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial. ( Boubaker, H; Boudhib, L; Bouida, W; Boukef, R; Claessens, YE; Grissa, MH; Kerkeni, W; Nouira, S, 2011) |
| "Acetaminophen alone may not be as effective in reducing pain-related physiological and behavioral changes as acetaminophen plus codeine or ibuprofen plus midazolam during diagnostic tympanocentesis." | 5.15 | Pain management in young children undergoing diagnostic tympanocentesis. ( Chandra, A; Colborn, DK; Hoberman, A; Hooper, EG; Kurs-Lasky, M; Reis, EC; Rockette, HE; Shaikh, N, 2011) |
| "This double-blind, randomized controlled study evaluated etoricoxib (90 and 120 mg), ibuprofen (600 mg), and acetaminophen (600 mg/codeine) (60 mg, (A/C)) in patients aged ≥ 18 years with moderate or severe pain after surgical extraction of ≥ 2 third molars (≥ 1 impacted)." | 5.15 | Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. ( Bandy, DP; Boice, J; Christensen, SE; Daniels, SE; Liu, H; Losada, MC; Mehta, A; Peloso, PM, 2011) |
| "Our objective was too assess the effectiveness of 3 analgesics (ibuprofen, naproxen sodium, and acetaminophen) and a placebo administered before and after the placement of separators in reducing the severity of postseparator placement pain." | 5.15 | Effects of analgesics on orthodontic pain. ( Fillingim, R; Logan, H; McGorray, SP; Patel, S; Wheeler, TT; Yezierski, R, 2011) |
| "To evaluate the efficacy and safety of the paracetamol-tramadol combination (PTC) in treating moderate-to-severe pain, in patients aged 65 years and over within general practitioner (GP) practice centers." | 5.15 | Epidemiological data, efficacy and safety of a paracetamol-tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practice. ( Ganry, H; Mejjad, O; Serrie, A, 2011) |
| " The effects of acetaminophen, tropisetron, the combination of both drugs, and saline on pain perception and central sensitization in healthy volunteers were compared." | 5.15 | Tropisetron blocks analgesic action of acetaminophen: a human pain model study. ( Bandschapp, O; Filitz, J; Koppert, W; Ruppen, W; Urwyler, A, 2011) |
| "To assess the spontaneous passage rate for patients being treated with alfuzosin 10mg daily after presenting with an acute ureteral stone compared with a control group, and to assess the respective pain control status." | 5.15 | Medical expulsive therapy using alfuzosin for patient presenting with ureteral stone less than 10mm: a prospective randomized controlled trial. ( Chau, LH; Fan, CW; Fung, BT; Li, JC; Li, MK; Tai, DC, 2011) |
| " The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings." | 5.15 | A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 5.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care." | 5.15 | A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011) |
| "The present study aimed to examine the effectiveness of intravenous administration of paracetamol added to morphine in the control of cancer pain and its possible contribution as reduction of opioid consumption and opioid-related side effects." | 5.14 | Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control. ( Aydinli, I; Keskinbora, K; Pekel, AF; Salihoglu, T; Sonsuz, A; Tasmacioglu, B, 2009) |
| "This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee." | 5.14 | Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa ( Berggren, AC; Karlsson, M, 2009) |
| "This study aims to evaluate the efficacy of methadone as substitute for morphine and to investigate if the addition of acetaminophen could reduce the time to attain an equianalgesic dose of methadone and/or to improve the level of pain control in oncologic patients." | 5.14 | Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study. ( Cubero, DI; del Giglio, A, 2010) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 5.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting." | 5.14 | Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. ( Friday, JH; Harley, JR; Kanegaye, JT; McCaslin, I; Zheng, A, 2009) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | 5.14 | A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| "5 mg kg(-1) for prevention of propofol induced pain." | 5.14 | Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol. ( Borazan, H; Erdem, TB; Kececioglu, M; Otelcioglu, S, 2010) |
| "To establish whether acetaminophen improves performance of self-paced exercise through the reduction of perceived pain, 13 trained male cyclists performed a self-paced 10-mile (16." | 5.14 | Influence of acetaminophen on performance during time trial cycling. ( Jones, AM; Mauger, AR; Williams, CA, 2010) |
| "The adjunctive use of paracetamol (acetaminophen) with strong opioids has become entrenched practice in palliative care pain management, despite little evidence to support its use." | 5.14 | Lack of benefit from paracetamol (acetaminophen) for palliative cancer patients requiring high-dose strong opioids: a randomized, double-blind, placebo-controlled, crossover trial. ( Charles, M; Israel, FJ; Parker, G; Reymond, L, 2010) |
| "This novel OA pain model was able to discriminate both tramadol/acetaminophen and naproxen from placebo after single and multiple doses." | 5.14 | A walking model to assess the onset of analgesia in osteoarthritis knee pain. ( Beals, CR; Bolognese, JA; Harman, A; Kivitz, AJ; Moskowitz, RW; Peeva, E; Smugar, SS; Taber, L, 2010) |
| "This study suggests that paracetamol, lornoxicam, and tramadol can be safely and efficiently preferred in pain control during SWL." | 5.14 | Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol representing three different groups of analgesics for pain control in extracorporeal shockwave lithotripsy. ( Akcali, GE; Balcioglu, YO; Cam, K; Demiraran, Y; Iskender, A; Kayikci, A; Yalcin, GS, 2010) |
| " Results of this research showed the better efficacy of erythromycin in controlling effusion and pain with functional improvement in patients with knee effusion due to OA." | 5.14 | A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis. ( Ardalan, MR; Ghojazadeh, M; Molaeefard, M; Moloudi, R; Noshad, H; Sadreddini, S, 2009) |
| "Etodolac-paracetamol was significantly superior to etodolac alone in reducing pain intensity (P<0." | 5.14 | Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation. ( Ambade, R; Bartakke, G; Chandanwale, A; Chandurkar, N; Pareek, A, 2010) |
| "To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain." | 5.14 | Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010) |
| "Acetaminophen plus codeine is effective in pain control in polytrauma patients at least in our series." | 5.14 | Acetaminophen plus codeine compared to ketorolac in polytrauma patients. ( Buccelletti, F; Calcinaro, S; Carroccia, A; De Marco, G; Franceschi, F; Gentiloni Silveri, N; Giannuzzi, R; Gilardi, E; Giupponi, B; Mancini, F; Marini, M; Marsiliani, D; Merra, G; Potenza, A, 2010) |
| "This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy." | 5.14 | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. ( Baik, SH; Cha, BY; Kim, CH; Kim, DS; Ko, KS; Ko, SH; Kwon, HS; Lee, JH; Mok, JO; Noh, JH; Park, IB; Park, TS; Son, HS; Yu, JM, 2010) |
| "Subjects were randomized (3:3:1) to receive IV acetaminophen (1,000mg q6h or 650mg q4h) or standard-of-care treatment for pain or fever." | 5.14 | Safety of multiple-dose intravenous acetaminophen in adult inpatients. ( Bergese, SD; Candiotti, KA; Royal, MA; Singla, NK; Singla, SK; Viscusi, ER, 2010) |
| " They were randomized to receive ibuprofen or paracetamol when pain relief was necessary." | 5.14 | Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study. ( David, LB; Livshits, A; Machtinger, R; Moshe-Zahav, A; Seidman, DS; Spira, M, 2009) |
| " Aim of this study was to examine the analgesic and antihyperalgesic properties of the weak opioid tramadol and the non-opioid acetaminophen, alone as well as in combination, in an experimental pain model in humans." | 5.13 | Supra-additive effects of tramadol and acetaminophen in a human pain model. ( Filitz, J; Günther, W; Ihmsen, H; Koppert, W; Schüttler, J; Schwilden, H; Tröster, A, 2008) |
| " acetaminophen seems to be effective in attenuating pain during i." | 5.13 | Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain. ( Arun, O; Canbay, O; Celebi, N; Karagöz, AH; Ozgen, S; Saricaoğlu, F, 2008) |
| "Acetaminophen 650 mg or ibuprofen 400 mg taken 1 hour prior to separator placement can reduce pain associated with the procedure." | 5.12 | Pharmacological Means of Pain Control during Separator Placement: A Systematic Review. ( Arishi, SA; Ghazwani, LY; Ghoussoub, MS; Jafer, MA; Patil, S; Sharawi, NA; Somaili, AMH; Somaili, RM; Sumayli, AH; Sumayli, MA, 2021) |
| "Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever." | 5.12 | Paracetamol: unconventional uses of a well-known drug. ( Bloukh, S; Matheson, C; Wazaify, M, 2021) |
| "The analgesic effect of acetaminophen/placebo (expressed as the area under the curve of the percentage of the individual pain score reported at baseline along time [% x min]) (2145 +/- 2901 % x min) was totally inhibited by both tropisetron (89 +/- 1747 % x min, P = ." | 5.12 | Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. ( Beaune, P; Dubray, C; Eschalier, A; Libert, F; Loriot, MA; Pickering, G, 2006) |
| "To examine, in routine practice, the effectiveness and cost-effectiveness of oxycodone (OxyContin) compared with standard therapy for osteoarthritis pain." | 5.12 | Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee. ( Buitendyk, M; Codding, C; Marshall, DA; Pericak, D; Strauss, ME; Torrance, GW, 2006) |
| "In this double-blind cross-over study, we assessed whether erythromycin infusion is effective as a prokinetic drug against gastroparesis from acute pain." | 5.12 | Erythromycin promotes gastric emptying during acute pain in volunteers. ( Allaouchiche, B; Bleyzac, N; Boselli, E; Bouvet, L; Chassard, D; Duflo, F; Mion, F, 2006) |
| "Administering 75 mg tramadol/650 mg acetaminophen orally with periprostatic 1% lidocaine before transrectal ultrasound guided prostate biopsy is a safe, easy and effective method of controlling pain during the biopsy procedure." | 5.12 | Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial. ( Carvin, DM; Costa, J; Pendleton, J; Rosser, CJ; Wludyka, P, 2006) |
| "The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC)." | 5.12 | Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat. ( Bey, M; Burnett, I; Grattan, T; Littlejohn, S; Sanner, K; Schachtel, B, 2006) |
| "0001) and was superior to pseudoephedrine and placebo for pain relief (p < or = 0." | 5.12 | Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. ( Burnett, I; Eccles, R; Jawad, M; Jawad, S; Jones, E; North, M; Ridge, D, 2006) |
| "5-mg/acetaminophen 325-mg combination tablets (tramadoUAPAP) as add-on therapy in subjects with rheumatoid arthritis (RA) pain that was inadequately controlled by NSAIDs and disease-modifying antirheumatic drugs alone." | 5.12 | Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial. ( Baek, HJ; Kim, HA; Lee, CK; Lee, EB; Lee, EY; Lim, MK; Park, BJ; Seo, YI; Sheen, DH; Shim, SC; Song, YW; Yoo, B, 2006) |
| "Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries." | 5.12 | A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007) |
| "The aim of this study was to determine the analgesic effect of acetaminophen compared to a combination of both caffeine and acetaminophen or caffeine alone using tonic and phasic pain stimulation." | 5.12 | Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. ( Beisel, A; Brune, K; Clarke, G; Grattan, T; Kobal, G; Mueller, C; Renner, B; Werner, U, 2007) |
| "Patients (N = 77, aged 8-14 y, 61% male) with ankle injuries presenting to a regional pediatric emergency department were assigned to receive either acetaminophen (15 mg/kg 4 times a day) or naproxen (5 mg/kg 4 times a day) in a double-blind fashion on a routine basis for a 5 day period." | 5.12 | Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children. ( Cukiernik, VA; Lim, R; Matsui, D; Rieder, MJ; Seabrook, JA; Warren, D, 2007) |
| "Combined tramadol/acetaminophen is used to treat pain related to osteoarthritis." | 5.12 | A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain. ( Bae, SC; Choe, JY; Choi, CB; Chung, WT; Hong, YH; Ji, JD; Kang, YM; Kim, HA; Kim, TH; Lee, CK; Lee, J; Lee, JT; Lim, MK; Nam, EJ; Park, SH; Seo, YI; Sheen, DH; Shim, SC; Song, GG; Song, JS; Suh, CH; Sung, YK, 2007) |
| " The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments." | 5.12 | Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. ( Bhasale, S; Deo, N; Gala, J; Mehta, K; Miller, MJ; Modak, M; Naik, S; Thakur, H, 2007) |
| "This study compared the efficacy and safety profile of buprenorphine transdermal delivery system (BTDS) and placebo in subjects with persistent noncancer-related pain who required opioid analgesics." | 5.12 | Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study. ( Carr, WD; Landau, CJ; Munera, C; Razzetti, AJ; Ripa, SR; Sessler, NE, 2007) |
| "It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries." | 5.12 | The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium. ( Agus, H; Kayali, C; Surer, L; Turgut, A, 2007) |
| "5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)." | 5.11 | Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004) |
| "5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients." | 5.11 | Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004) |
| "To compare the effects of providing analgesia with either transdermal fentanyl (TTS-fentanyl) or paracetamol and codeine (P/C) in addition to radiotherapy in patients with metastatic bone pain." | 5.11 | Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. ( Eleftheriadis, N; Georgakopoulos, G; Gompakis, N; Kouloulias, VE; Kouvaris, J; Mystakidou, K; Pistevou-Gompaki, K; Varveris, C, 2004) |
| "This study clearly showed the efficacy of a short course of oral prednisone (3 days), versus a placebo, in the treatment of the functional signs of acute maxillary rhinosinusitis with severe pain in adults in addition to an appropriate antibiotic treatment." | 5.11 | [Treatment of functional signs of acute maxillary rhinosinusitis in adults. Efficacy and tolerance of administration of oral prednisone for 3 days]. ( Bordure, P; Coriat, F; Deslandes, B; Desmonts-Gohler, C; Dubreuil, C; Gehanno, P; Gilain, L; Jankowski, R; Klossek, JM; Serrano, E; Stoll, D, 2004) |
| "In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of >or= 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (singledose phase) followed by 5/325 mg every 6h as needed (multidose phase), or placebo." | 5.11 | Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial. ( Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA, 2004) |
| "To determine in a sample of nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of acetaminophen in reducing discomfort." | 5.11 | A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia. ( Brod, M; Buffum, MD; Miaskowski, C; Sands, L; Washburn, A, 2004) |
| "To determine whether adding regular acetaminophen (paracetamol) could improve pain and well-being in people with advanced cancer and pain despite strong opioids." | 5.11 | Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial. ( Pillai, A; Stockler, M; Vardy, J; Warr, D, 2004) |
| "Subjects with moderate or greater wrist pain were randomized and stratified to 1 of the following treatments: efficacy evaluation (heat wrap, n=39; oral placebo, n=42) or blinding (oral acetaminophen, n=6; unheated wrap, n=6)." | 5.11 | Continuous low-level heat wrap therapy is effective for treating wrist pain. ( Erasala, GN; Hengehold, DA; Hun, L; Michlovitz, S; Weingand, KW, 2004) |
| "It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of nasal congestion associated with the common cold." | 5.11 | Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold. ( Loose, I; Winkel, M, 2004) |
| "To compare the safety and efficacy of a new cyclooxygenase-2 inhibitor, valdecoxib, with those of an oxycodone-acetaminophen combination in patients with acute musculoskeletal pain." | 5.11 | Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. ( Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A, 2004) |
| "Patients with mild to moderate pain were randomised to either: paracetamol up to 3 g/d, aspirin up to 3 g/d or ibuprofen up to 1200 mg/d for 7 days." | 5.11 | A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data. ( Jones, JK; Moore, N; Parc, JM; Schneid, H; Van Ganse, E; Wall, R, 2005) |
| "To compare efficacy and safety of strepfen (flurbiprofen) to those of oral paracetamol in acute infections of the upper respiratory tracts for relief of throat pain (TP)." | 5.11 | [Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain]. ( Balandin, AV; Dimova, AD; Sedinkin, AA, 2005) |
| "To compare the analgesic effect of single doses of etoricoxib 120 mg, oxycodone/ acetaminophen 10 mg/650 mg and codeine/ acetaminophen 60 mg/600 mg in acute pain using the dental impaction model." | 5.11 | The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain. ( Ang, J; Fricke, JR; Malmstrom, K; Reicin, A; Shingo, S, 2005) |
| "There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone." | 5.11 | Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005) |
| "The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea." | 5.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815)." | 5.10 | Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. ( Cairns, R; Le Parc, JM; Moore, N; Schneid, H; van Ganse, E; Wall, R, 2002) |
| "The objectives of this study were to compare the incidence, onset, duration and pain scores of transient neurologic symptoms (TNS) with 1% versus 5% hyperbaric lidocaine in spinal anesthesia for short urological procedures in a large prospective study." | 5.10 | Prospective study on incidence and functional impact of transient neurologic symptoms associated with 1% versus 5% hyperbaric lidocaine in short urologic procedures. ( Bremang, J; Chung, F; Friedlander, M; Mezei, G; Streiner, D; Tong, D; Wong, J, 2003) |
| "5 mg tramadol/325 mg acetaminophen) for the treatment of fibromyalgia pain." | 5.10 | Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study. ( Bennett, RM; Kamin, M; Karim, R; Rosenthal, N, 2003) |
| "The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain." | 5.10 | Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002) |
| "Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol." | 5.09 | Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol. ( Bhagat, K; Lala, I; Leech, P; Montgomery, L, 2000) |
| "To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain." | 5.09 | Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999) |
| "In this prospective clinical trial, term neonates wtih painful conditions or who were undergoing painful procedures received multiple-dose acetaminophen." | 5.09 | Multiple-dose pharmacokinetics of rectally administered acetaminophen in term infants. ( Deinum, HT; Okken, A; Quak, CM; Tibboel, D; van Lingen, RA, 1999) |
| "This randomized, double-blind, placebo-controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg--an effervescent solution and tablet--in 242 patients with moderate or severe pain following dental surgery." | 5.09 | Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study. ( Ganry, HE; Insuasty, JH; Møller, PL; Nørholt, SE; Sindet-Pedersen, S; Skoglund, LA; Vincent, FG, 2000) |
| "Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers." | 5.09 | Combined analgesia and local anesthesia to minimize pain during circumcision. ( Gilbert-MacLeod, C; Koren, G; Ohlsson, K; Pollock, N; Taddio, A, 2000) |
| "5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain." | 5.09 | Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000) |
| "To determine whether greater pain intensity at initiation of treatment predicted better response to ibuprofen than to acetaminophen in subjects with knee osteoarthritis (OA)." | 5.09 | Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001) |
| "Opioid/acetaminophen (APAP) combination analgesics are widely prescribed for the relief of moderate pain." | 5.09 | Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. ( Lacy, JR; Mullican, WS, 2001) |
| "Ibuprofen and acetaminophen with codeine had similar analgesic properties in the first 24 hours post partum (mean pain rating 3." | 5.09 | Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. ( Douglas, MJ; Grange, CS; Janssen, PA; Peter, EA, 2001) |
| "The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia." | 5.08 | Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998) |
| "To evaluate the efficacy of an oral tramadol preparation versus that of an oral hydrocodone-acetaminophen preparation in acute musculoskeletal pain." | 5.08 | Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. ( Larkin, GL; Paris, PM; Turturro, MA, 1998) |
| " Acetaminophen and meperidine were given for postoperative pain." | 5.07 | Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994) |
| "Lysine clonixinate (LC), an effective and well tolerated non-morphinic analgesic whose mechanism of action is basically due to the inhibition of cyclo-oxygenase, was assessed with a double-blind randomized dummy design versus paracetamol (P) on 200 patients suffering from pain after minor dental surgery." | 5.07 | Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol. ( De los Santos, AR; Di Girolamo, G; Fraga, C; Gil, M; Manero, EO; Martí, ML, 1993) |
| "Recognizing the concerns about the use of local anesthesia in neonatal circumcision, a painful procedure usually performed without analgesia or anesthesia, we undertook a study of acetaminophen for pain management of this procedure." | 5.07 | Acetaminophen analgesia in neonatal circumcision: the effect on pain. ( Howard, CR; Howard, FM; Weitzman, ML, 1994) |
| "The full dose of acetaminophen significantly reduced the incidence of sore arm and nausea without affecting the antibody response." | 5.07 | Effects of acetaminophen on adverse effects of influenza vaccination in health care workers. ( Aoki, FY; Cheang, M; Hammond, GW; Murdzak, C; Seklà, LH; Wright, B; Yassi, A, 1993) |
| "In a double-blind study of 18 patients with coxarthrosis the effect of 3 naproxen doses (0." | 5.07 | Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients. ( Neander, G; Samuelson, P; Seideman, P, 1993) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 5.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "To assess the sore throat pain model in children as an assay for systemic analgesic agents in children under double-blind, placebo-controlled conditions, we conducted a single-dose parallel study that compared 10 mg/kg ibuprofen (n = 39), a new analgesic agent for children, and 15 mg/kg acetaminophen (n = 38), an approved analgesic for children, to placebo (n = 39) in children from 2 to 12 years of age with acute sore throat." | 5.07 | A placebo-controlled model for assaying systemic analgesics in children. ( Schachtel, BP; Thoden, WR, 1993) |
| "Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers." | 5.07 | Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity. ( Bromm, B; Forth, W; Richter, E; Scharein, E, 1992) |
| "In a randomized, double-blind prospective manner, patients received either 5 mg hydrocodone with 500 mg acetaminophen or 30 mg codeine with 500 mg acetaminophen to take on discharge from the ED and every four hours thereafter as needed for pain." | 5.07 | Hydrocodone versus codeine in acute musculoskeletal pain. ( Menegazzi, JJ; Paris, PM; Turturro, MA; Yealy, DM, 1991) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 5.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "In a double-blind, placebo-controlled study the efficacy and safety of topical ketorolac tromethamine were assessed in the reduction of inflammation and pain due to ankle sprain." | 5.06 | A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate. ( Bullingham, R; Diebschlag, W; Nocker, W, 1990) |
| "This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip." | 5.06 | Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990) |
| "The analgesic efficacy of acetaminophen sustained release (SR) and acetaminophen immediate plus sustained release (IR + SR) was evaluated in 200 outpatients with pain after oral surgery." | 5.06 | Analgesic efficacy of acetaminophen sustained release. ( Engevall, S; Forsberg, O; Larsson, O; Quiding, H; Ström, C, 1990) |
| "Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control." | 5.06 | The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988) |
| " Eight hundred and forty-six patients with pain in one or two joints of the hip, knee, ankle or wrist participated in a randomised double-blind trial to compare the efficacy, tolerability and effect on quality of life of diclofenac sodium slow release (DSR) 100 mg daily and a combination of dextropropoxyphene 180 mg and paracetamol 1." | 5.06 | Joint pain and quality of life; results of a randomised trial. ( Bulpitt, CJ; Darekar, B; Fletcher, A; Parr, G, 1989) |
| "We compared naproxen sodium (550 mg) and propoxyphene napsylate with acetaminophen (PN/A, 100 mg with 650 mg) for pain relief after arthroscopy or arthroscopic meniscectomy." | 5.06 | Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen. ( Drez, D; Ritter, M; Rosenberg, TD, 1987) |
| "A double-blind multicenter cross-over study was conducted on 166 outpatients with painful chronic osteoarthritis of the hip and of the femoro-tibial joints, to compare the effectiveness of glafenine and paracetamol." | 5.06 | A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach. ( Amor, B; Benarrosh, C, 1988) |
| " The second study compared three weeks of treatment with daily doses of 200 mg of flurbiprofen and 4 g of acetaminophen in 50 patients with acute low back pain." | 5.06 | Flurbiprofen for the treatment of soft tissue trauma. ( Muckle, DS, 1986) |
| "To test the hypothesis that the postoperative abdominal pain of tubal occlusion is mediated by prostaglandins, the effects of meclofenamate, a potent inhibitor of cyclooxygenase, on postoperative analgesia and incidence of abdominal pain were compared with those of acetaminophen, a weak inhibitor of prostaglandin activity." | 5.06 | Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion. ( Caissie, KF; Huang, KC; Simpson, PM; Tsueda, K; Wolfe, WM, 1986) |
| " Patients with tonsillopharyngitis randomly received either 400 mg ibuprofen (n = 39), 1000 mg acetaminophen (n = 40), or placebo (n = 41)." | 5.06 | Sore throat pain in the evaluation of mild analgesics. ( Baybutt, RI; Fillingim, JM; Lane, AC; Schachtel, BP; Thoden, WR, 1988) |
| "Fifty college athletes with acute sprains and strains from football-related activities were randomly assigned to treatment with either diflunisal or acetaminophen with codeine for seven days." | 5.06 | Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. ( Indelicato, PA, 1986) |
| "Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children." | 5.05 | Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 5.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "The efficacy and acceptability of meptazinol and dextropropoxyphene plus paracetamol were compared in 32 elderly patients with various types of musculoskeletal pain." | 5.05 | A comparison between meptazinol and dextropropoxyphene plus paracetamol in elderly patients with musculoskeletal pains. ( Orö, L, 1984) |
| "Twenty-five patients suffering from primary dysmenorrhoea took part in a double-blind crossover study which demonstrated flurbiprofen (100 mg three times a day) to be significantly more effective than paracetamol (1 g three times a day) in providing pain relief on Days 1 and 2, and on the worst day of pain." | 5.05 | A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea. ( Maclean, D, 1983) |
| "In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)." | 5.05 | A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984) |
| "The clinical efficacy and tolerability of a combination preparation ('Norgesic') of 35 mg orphenadrine plus 450 mg paracetamol was compared with that of placebo in a controlled double-blind, parallel group, 7-day study comprising 44 patients suffering from pain due to tension of the cervical and upper thoracic musculature." | 5.05 | Effect of a combination of orphenadrine/paracetamol tablets ('Norgesic') on myalgia: a double-blind comparison with placebo in general practice. ( Høivik, HO; Moe, N, 1983) |
| "In a double-blind cross-over trial of azapropazone and indomethacin in 20 patients with osteoarthritis of the hip and knee with four weeks on each drug, three methods of assessing pain and pain relief were used." | 5.05 | A comparison of three ways of measuring pain. ( Frank, AJ; Hort, JF; Moll, JM, 1982) |
| "A double-blind study was carried out in 90 patients with acute or chronic painful musculoskeletal conditions of at least moderate severity to compare the effectiveness over a 72-hour period of oral treatment, 3 to 6 hourly, with 200 mg meptazinol, 1 g paracetamol and placebo." | 5.05 | A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner. ( Wade, AG; Ward, PJ, 1982) |
| "A double-blind study was carried out in 48 patients with soft-tissue injuries to compare the effectiveness of mefenamic acid and dextropropoxyphene plus paracetamol in relieving acute post-injury pain." | 5.04 | Mefenamic acid and dextropropoxyphene with paracetamol as analgesics in the accident department. ( Stableforth, PG, 1977) |
| "A preliminary double-blind, randomized trial was carried out in general practice to compare the efficacy of treatment with diflunisal (500 mg) twice daily and a combination of dextropropoxyphene (65 mg) plus paracetemol (650 mg) 3-times daily for 3 days in relieving pain associated with strains and sprains." | 5.04 | A controlled study of diflunisal in sprains and strains. ( Grimshaw, JJ; Jaffé, GV; Roylance, PJ, 1978) |
| "Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis." | 5.04 | A clinical Trial of Tofranil in osteo-arthritis. ( Glick, EN, 1976) |
| "Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics--floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine--were compared." | 5.04 | A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice. ( Gay, J; Lomas, DM; Midha, RN; Postlethwaite, DL, 1976) |
| "This article reviews the mechanisms of action, clinical use, and recent scientific evidence for the use of nonsteroidal antiinflammatory drugs, grapiprant, acetaminophen (paracetamol), metamizole (dipyrone), and corticosteroids in pain management." | 5.01 | Antiinflammatory Drugs. ( Monteiro, B; Steagall, PV, 2019) |
| " Mean pain scores were: opioids ± NSAIDs ± acetaminophen (4." | 5.01 | Pain Management Protocols During Uterine Fibroid Embolisation: A Systematic Review of the Evidence. ( Anthony, S; Elzein, A; Husainy, MA; Makris, GC; Patel, R; Saibudeen, A; Uberoi, R; Wigham, A, 2019) |
| "With respect to analgesics use, we employed data from national registries on the analgesic prescription use (opioids, nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen) in 2017 among elderly people with and without dementia." | 5.01 | Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review. ( Bandak, E; Christensen, MB; Johannsen, P; Kallehauge, H; Lolk, A; Pedersen, H; Saxtrup, N; Solem, EJ; Sørensen, AMS; Tarp, S, 2019) |
| "- Paracetamol or ibuprofen should only be given when there is a combination of fever and pain." | 4.95 | [Revision of the Dutch College of General Practitioners practice guideline 'Children with fever']. ( Eizenga, WE; Opstelten, W, 2017) |
| "Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a focused analysis." | 4.95 | Perinatal and neonatal use of paracetamol for pain relief. ( Allegaert, K; van den Anker, JN, 2017) |
| "Based on a PubMed database literature search on the terms efficacy, safety, paracetamol, acetaminophen, codeine and their combinations up to and including June 2016, this clinical update reviews the current evidence of the benefit and risks of oral paracetamol alone and with codeine for mild-to-moderate pain in adults, and compares the respective efficacy and safety profiles with those of nonsteroidal anti-inflammatory drugs (NSAIDs)." | 4.95 | Clinical update on benefit versus risks of oral paracetamol alone or with codeine: still a good option? ( Kress, HG; Untersteiner, G, 2017) |
| "The objectives of this review were to assess the ability of both pharmacological and non-pharmacological interventions to reduce or eliminate the pain that accompanies rocuronium bromide administration." | 4.93 | Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. ( Ali, Z; Kalaivani, M; Prabhakar, H; Singh, GP; Smith, MA, 2016) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 4.93 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016) |
| " All treatments except acetaminophen showed clinically significant improvement from baseline pain." | 4.91 | Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. ( Bannuru, RR; Kent, DM; McAlindon, TE; Schmid, CH; Vaysbrot, EE; Wong, JB, 2015) |
| "Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever in children." | 4.90 | Paracetamol: a focus for the general pediatrician. ( Barbi, E; Guarino, S; Marzuillo, P, 2014) |
| "To determine the efficacy and safety of codeine used alone or in combination with paracetamol for relieving cancer pain." | 4.90 | Codeine, alone and with paracetamol (acetaminophen), for cancer pain. ( Bell, RF; Derry, S; Jackson, KC; Strassels, S; Straube, C; Straube, S; Wiffen, PJ, 2014) |
| "Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain." | 4.89 | Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013) |
| "Acetaminophen/codeine combination is effective in the treatment of moderate to severe pain in all setting analyzed in this study, which include headache, postoperative, osteoarticular and post-traumatic." | 4.89 | Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin. ( Alesi, A; Antonini, EF; Cordischi, C; Franceschi, F; Giacobelli, D; Iacomini, P; Marsiliani, D; Zuccalà, G, 2013) |
| " In paediatric populations, ibuprofen and paracetamol (acetaminophen) are both commonly used over-the-counter medicines for the management of fever or mild-to-moderate pain associated with sore throat, otitis media, toothache, earache and headache." | 4.89 | Optimising the management of fever and pain in children. ( van den Anker, JN, 2013) |
| "To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness." | 4.88 | Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012) |
| "To systematically review the literature on the efficacy and safety of paracetamol (acetaminophen) in the management of pain in inflammatory arthritis." | 4.88 | Paracetamol for the management of pain in inflammatory arthritis: a systematic literature review. ( Bombardier, C; Hazlewood, G; van der Heijde, DM, 2012) |
| "To systematically review the literature on the safety of using nonsteroidal antiinflammatory drugs (NSAID) and/or paracetamol in people receiving methotrexate (MTX) for inflammatory arthritis (IA), as an evidence base for generating clinical practice recommendations." | 4.88 | Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review. ( Colebatch, AN; Edwards, CJ; Marks, JL; van der Heijde, DM, 2012) |
| "Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited." | 4.87 | Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011) |
| "Ibuprofen is as or more efficacious than acetaminophen for the treatment of pain and fever in adult and pediatric populations and is equally safe." | 4.86 | Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. ( Pierce, CA; Voss, B, 2010) |
| "Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain." | 4.86 | Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010) |
| "To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions." | 4.86 | A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine. ( Day, R; Graham, G; Palmer, H; Williams, K, 2010) |
| "Intravenous paracetamol (rINN)/intravenous acetaminophen (USAN) is an analgesic and antipyretic agent, recommended worldwide as a first-line agent for the treatment of pain and fever in adults and children." | 4.85 | Intravenous paracetamol (acetaminophen). ( Duggan, ST; Scott, LJ, 2009) |
| "To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain." | 4.84 | Effectiveness of oral vs rectal acetaminophen: a meta-analysis. ( Berkovitch, M; Berlin, M; Goldstein, LH; Kozer, E, 2008) |
| "Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage." | 4.84 | Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007) |
| "To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen." | 4.84 | COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008) |
| " Pharmacologic approaches to pain treatment include acetaminophen, anti-inflammatory agents, opiates, and bisphosphonates." | 4.83 | Cancer-related pain and its pharmacologic management in the patient with bone metastasis. ( Slatkin, N, 2006) |
| "Nonopioid analgesics, which include acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2)-specific inhibitors (coxibs), are frequently used for the relief of mild-to-moderate pain." | 4.83 | Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. ( Whelton, A, 2006) |
| "Data supporting the rationale of combining tramadol and acetaminophen to provide pain relief will be reviewed in addition to clinical data demonstrating the efficacy and safety of this combination in acute and chronic pain states." | 4.82 | The new analgesic combination tramadol/acetaminophen. ( Schnitzer, T, 2003) |
| "Paracetamol (acetaminophen) has been shown to be an effective analgesic for the treatment of moderate pain where it is chiefly indicated, as shown in placebo-controlled studies in the perioperative setting and other acute pain states." | 4.82 | [Role of paracetamol in the acute pain management]. ( Kehlet, H; Werner, MU, 2003) |
| "To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever." | 4.82 | Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004) |
| "To assess the efficiency of paracetamol, indicated in first instance for light-to-moderate pain from hip and knee arthrosis, against rofecoxib, the COX-2 inhibitor most commonly used in Spain." | 4.82 | [Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip]. ( Lizán Tudela, L; Magaz Marqués, S; Riesgo Bucher, Y; Varela Moreno, C, 2004) |
| "The treatment of acute or chronic pain of variable intensity and origin, is efficiently achieved by the association of paracetamol and codeine." | 4.81 | [Efficacy and safety of acetaminophen-codeine in the treatment of pain]. ( Hantson, P, 2002) |
| "Paracetamol (acetaminophen) has a unique role in children because it is the first-line choice for the treatment of both fever and pain." | 4.80 | Paracetamol efficacy and safety in children: the first 40 years. ( Coghlan, D; Cranswick, N, 2000) |
| "Paracetamol (acetaminophen) is one of the most widely used of all drugs, with a wealth of experience clearly establishing it as the standard antipyretic and analgesic for mild to moderate pain states." | 4.80 | Paracetamol: past, present, and future. ( Prescott, LF, 2000) |
| "Injections of diclofenac induced antinociception in visceral pain models (writhing test, colorectal distension test), but not in two models of somatosensory pain (tail-flick and hot-plate test)." | 4.79 | Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. ( Björkman, R, 1995) |
| " Pooled efficacy results indicated that codeine added to paracetamol provided a 5% increase in analgesia on the sum pain intensity difference." | 4.79 | Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review. ( de Craen, AJ; Di Giulio, G; Kessels, AG; Kleijnen, J; Lampe-Schoenmaeckers, JE, 1996) |
| "In order to assess the analgesia obtained from single oral doses of paracetamol alone and in combination with codeine in postoperative pain, we conducted a systematic review of randomised controlled trials." | 4.79 | Paracetamol with and without codeine in acute pain: a quantitative systematic review. ( Carroll, D; Collins, S; McQuay, H; Moore, A, 1997) |
| "Paracetamol, codeine, and tramadol are commonly used to manage mild pain, and their availability without prescription or medical consultation raises concerns about potential opioid addiction." | 4.31 | Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study. ( Alvarez-Mon, M; Alvarez-Mon, MA; Carabot, F; Donat-Vargas, C; Fraile-Martínez, O; García-Montero, C; Monserrat, J; Ortega, MA; Santoma-Vilaclara, J; Zaragoza, C, 2023) |
| "A prediction model development study was completed using the 2006 American Migraine Prevalence and Prevention Study survey, from participants who were aged ≥18, met criteria and headache day frequency for episodic migraine, did not take prescription medication for migraine, and used ≥1 of the following acute migraine medication classes: acetaminophen, aspirin, NSAIDs, or caffeine containing combination products (CCP)." | 4.12 | Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. ( Armand, CE; Buse, DC; Ezzati, A; Fanning, KM; Lipton, RB; Martin, VT; Pavlovic, JM; Reed, ML, 2022) |
| " PPS was associated with reduced pain as well as a reduction in paracetamol and morphine use." | 4.12 | Immediate full weight bearing after pelvic percutaneous fixation by screw for simple acetabular and pelvic ring fractures in patients older than sixty five years. ( Benhenneda, R; Di Francia, R; Dubrana, F; Letissier, H, 2022) |
| "Acetaminophen is widely used to treat mild to moderate pain and to reduce fever." | 4.12 | Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection. ( Han, J; Li, W; Zhang, X, 2022) |
| "Overall, 74% of women reported acetaminophen use during pregnancy." | 4.12 | Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes. ( Bandoli, G; Chambers, C; Killion, JA; Smith, CJF, 2022) |
| "Paracetamol, one of the most widely used pain-relieving drugs, is deacetylated to 4-aminophenol (4-AP) that undergoes fatty acid amide hydrolase (FAAH)-dependent biotransformation into N-arachidonoylphenolamine (AM404), which mediates TRPV1-dependent antinociception in the brain of rodents." | 4.02 | Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity. ( Å Nilsson, JL; Blomgren, A; Blomqvist, A; Boudieu, L; Eschalier, A; Grundemar, L; Mallet, C; Nilsson, UJ; Shionoya, K; Sundin, AP; Zygmunt, PM, 2021) |
| "The inclusion of IV acetaminophen as part of a multimodal pain regimen led to fewer episodes of delirium in this study." | 3.96 | Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients. ( Connolly, KP; Kleinman, RS; Mehta, SN; Neuman, MD; Stevenson, KL, 2020) |
| "Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy." | 3.96 | Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. ( Bandoli, G; Chambers, C; Palmsten, K, 2020) |
| "ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan." | 3.96 | Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception. ( Micov, A; Pecikoza, U; Stepanović-Petrović, R; Tomić, M; Vuković, M, 2020) |
| "Paclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment." | 3.96 | Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats. ( Brusco, I; Ferreira, J; Hausen, BDS; Moresco, RN; Oliveira, SM; Pinheiro, KV; Rigo, FK, 2020) |
| " Pain medication consisted of ibuprofen 600 mg and paracetamol 1000 mg, first doses taken simultaneously with misoprostol and repeated, if needed, up to three times daily." | 3.96 | Pain during medical abortion in early pregnancy in teenage and adult women. ( Heikinheimo, O; Kemppainen, V; Mentula, M; Palkama, V, 2020) |
| "Paracetamol (acetaminophen) is widely used for management of mild-to-moderate pain and reduction of fever." | 3.91 | Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol. ( Dosenovic, S; Margan Koletic, Z; Puljak, L, 2019) |
| " Analgesics were coded as any pain medication, counts (total analgesics, number of opioids and nonopioids), equianalgesics (oral morphine equivalents, oral acetaminophen equivalents), and dose categories." | 3.91 | Analyzing Analgesic Medications in Community-Dwelling Older Adults. ( Farland, MZ; Horgas, AL; Marsiske, M; Snigurska, U, 2019) |
| "Acetaminophen has long been assumed to selectively alleviate physical pain, but recent research has started to reveal its broader psychological effects." | 3.91 | Acetaminophen influences social and economic trust. ( Krajbich, I; Roberts, ID; Way, BM, 2019) |
| " To assess the usefulness of this model for testing potential analgesics, three known synthetic pain medications were assessed (ibuprofen, acetaminophen and tramadol) along with three naturally occurring products (honokiol, tetrahydrocannabinol and cannabidiol)." | 3.88 | Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. ( Achenbach, JC; Berrue, F; Ellis, LD; Hill, J; McDougall, JJ; Morash, M, 2018) |
| " tramadol, codeine, or opium-containing drugs, or by PC for a weak level of pain." | 3.88 | Use of analgesics in France, following dextropropoxyphene withdrawal. ( Aubrun, F; Belhassen, M; Chrétien, E; Cornu, C; Ecoffey, C; Ginoux, M; Van Ganse, E, 2018) |
| "There are contrasting positions concerning the benefit-risk ratio of acetaminophen use for osteoarthritis (OA)-related pain." | 3.85 | Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care. ( Cricelli, C; Cricelli, I; Fanelli, A; Fornasari, D; Lapi, F; Lombardi, N; Lora Aprile, P; Simonetti, M; Vannacci, A, 2017) |
| "About a year after dextropropoxyphene (DXP) withdrawal from the French market, we conducted a survey among members of the French Society of Anesthesia & Intensive Care Medicine (Sfar) and of the French Society of the Study and Treatment of Pain (SFETD) to identify the indications for which this WHO level II analgesic had been prescribed, the prescriber's feedback following withdrawal, and the substitutive analgesics prescribed." | 3.85 | What are the therapeutic alternatives to dextropropoxyphene in France? A prescribers' survey. ( Aubrun, F; Belhassen, M; Beloeil, H; Chrétien, E; Ginoux, M; Lanteri-Minet, M; Letrilliart, L; Van Ganse, E, 2017) |
| "Women who used naproxen or opioids had slightly lower fecundability than women who did not use any pain-relieving medications; use of acetaminophen, aspirin and ibuprofen was not appreciably associated with fecundability." | 3.85 | Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study. ( Hatch, EE; McInerney, KA; Mikkelsen, EM; Rothman, KJ; Wesselink, AK; Wise, LA, 2017) |
| "Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain." | 3.85 | Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017) |
| "This study was designed to formulate a drug in adhesive transdermal patch with codeine (CDB) and acetaminophen (APAP) that may potentially treat moderate pain in children." | 3.83 | Formulation optimization of a drug in adhesive transdermal analgesic patch. ( Abla, MJ; Banga, AK; Herwadkar, AK; Little, J; Ravula, R, 2016) |
| "Data of patients treated with a combination of oxycodone (5, 10, and 20 mg) and acetaminophen (325 mg) were evaluated for gender, current disease condition, basal pain intensity, total daily dose, days of controlled pain at the initial low dose, and pain intensity after treatment using a numeric pain rating scale." | 3.83 | Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better. ( Carpenedo, R; Dauri, M; Lazzari, M; Mammucari, M; Natoli, S; Palombo, E; Silvi, MB, 2016) |
| "Although most patients were prescribed IR hydrocodone/acetaminophen for acute pain, the number of patients prescribed long-term therapy exceeds the number of patients prescribed ER opioids." | 3.81 | A retrospective cohort study of long-term immediate-release hydrocodone/acetaminophen use and acetaminophen dosing above the Food and Drug Administration recommended maximum daily limit among commercially insured individuals in the United States (2008-201 ( Alexander, L; Chilcoat, H; Coplan, P; DeVeaugh-Geiss, A; Kadakia, A, 2015) |
| " These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain." | 3.80 | Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014) |
| "The primary objective was to assess whether patients with a fever are treated with acetaminophen or ibuprofen more promptly than they are treated for pain." | 3.80 | Is fever treated more promptly than pain in the pediatric emergency department? ( Bair, J; Dvorkin, R; Glantz, S; Marguilies, J; Patel, H; Rosalia, A; Yens, DP, 2014) |
| "Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking." | 3.80 | Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014) |
| " In the writhing test, pain responses were scored every 5 min during a 30-min period after intraperitoneal injection of diluted acetic acid." | 3.80 | Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. ( Lupusoru, CE; Lupusoru, RV; Mititelu Tartau, L; Ochiuz, L; Popa, EG; Stoleriu, I, 2014) |
| "This prospective, observational, multicenter study enrolled patients who consulted general practitioners across France for intense pain that lasted ≥7 days and for which the physician prescribed paracetamol-codeine or paracetamol-tramadol." | 3.79 | Semiological evaluation of pain according to its origin: a prospective, observational, and national study of current French medical practice. ( Bertin, P; Taieb, C, 2013) |
| " Tramadol/acetaminophen medication was effective in reducing pain in seven of nine cases(77." | 3.79 | [Efficacy of tramadol/acetaminophen medication for central post-stroke pain]. ( Hirano, M; Kajita, Y; Nakahara, N; Noda, H; Takebayashi, S; Tanei, T; Wakabayashi, T, 2013) |
| " Paracetamol (acetaminophen) is generally recommended as a first-choice analgesic in osteoarthritis pain." | 3.79 | Managing osteoarthritis pain in the older population. ( Cunningham, E; Passmore, P, 2013) |
| "In pediatric palliative care, acetaminophen is also used as an adjuvant to opioid therapy for pain as well as an anti-pyretic." | 3.79 | Use of intravenous acetaminophen (paracetamol) in a pediatric patient at the end of life: case report. ( Keefer, P; Marks, AD; Saul, D, 2013) |
| "The responses pertaining to opioid agreements, urine drug testing, acetaminophen, and treatment for neuropathic pain are reassuring in that they prevent misuse and abuse of opioids, prevent acetaminophen-induced hepatotoxicity, and reflect evidence-based treatments." | 3.79 | Prescription patterns of pain medicine physicians. ( Avram, MJ; Benzon, HA; Benzon, HT; Cox, P; Dean, K; Katz, JA; Kendall, MC; Malik, K, 2013) |
| " Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests." | 3.78 | Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012) |
| "Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval." | 3.78 | Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012) |
| "This is a pharmacokinetic study of 30 postpartum women receiving hydrocodone bitartrate for postpartum pain in the inpatient setting." | 3.77 | Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. ( Anderson, PO; Lane, JR; Nguyen, N; Rafie, S; Rossi, SS; Sauberan, JB; Stellwagen, LM, 2011) |
| " This study was undertaken to determine the nature of the interaction between codeine and celecoxib or etoricoxib in peritoneal irritation-induced visceral pain in mice." | 3.77 | Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice. ( Janovsky, M; Krsiak, M, 2011) |
| "We highlight the risk associated with acetaminophen misuse in patients having dental pain in France based on a series of cases of unintentional acetaminophen overdose reported by the Emergency Dental Service of Nancy over a 9-month period." | 3.77 | Misuse of acetaminophen in the management of dental pain. ( Clement, C; Gambier, N; Gillet, P; Javot, L; Petitpain, N; Royer-Morrot, MJ; Scala-Bertola, J; Trechot, P, 2011) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 3.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| "5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients." | 3.76 | Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients. ( Chang, CS; Chung, CY; Ho, ML; Hsu, NC; Lin, HY; Wang, CC, 2010) |
| "Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever in western countries." | 3.76 | Acetaminophen induces apoptosis in rat cortical neurons. ( Blanco, A; Ceña, V; Muñoz-Fernández, M; Posadas, I; Santos, P, 2010) |
| "001) dose-dependent analgesic effect in the tail flick, hot plate, and tail clip (central) as well as in acetic acid-induced writhing (peripheral) nociceptive tests in mice, suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response." | 3.76 | Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens. ( Kumar, CT; Mpharm, TB, 2010) |
| "Many traditional Indian medicinal plants which contain large quantity of a secoiridoid, swertiamarin are being used to relieve pain." | 3.75 | Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. ( Badami, S; Jaishree, V; Rupesh Kumar, M; Tamizhmani, T, 2009) |
| "Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet." | 3.75 | The analgesic effect of decursinol. ( Choi, SM; Huh, GH; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Sim, YB; Suh, HW, 2009) |
| "Studies from the UK and USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking." | 3.74 | The relation between paracetamol use and asthma: a GA2LEN European case-control study. ( Bergmann, KC; Bonini, S; Bruno, A; Burney, P; De Rudder, I; Fokkens, W; Gjomarkaj, M; Gnatiuc, L; Godnic-Cvar, J; Heinzerling, L; Janson, C; Joos, G; Kowalski, ML; Loureiro, C; Makowska, J; Pace, E; Potts, J; Sanjuas, C; Shaheen, S; Skadhauge, L; Thomsen, G; Todo-Bom, A; van Durme, Y; van Zele, T; Villanueva, CM; Weersink, EJ; Wöhrl, S; Zock, JP; Zuberbier, T, 2008) |
| "The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)." | 3.74 | Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007) |
| "Morphine and other opioids are the mainstay of cancer pain management, yet considerable fears surrounding them present barriers to pain control." | 3.74 | Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. ( Gooberman-Hill, R; Hanks, GW; Reid, CM, 2008) |
| "Acetaminophen is an effective mild analgesic and antipyretic agent." | 3.74 | Acetaminophen. ( Ameer, B; Greenblatt, DJ, 1977) |
| "Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain." | 3.73 | Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain. ( Aoe, T; Saito, O; Yamamoto, T, 2005) |
| " Ambulance officers' concern about the pain of injection is the major identified factor for the relative underuse of morphine observed in younger children." | 3.73 | Paediatric prehospital analgesia in Auckland. ( Watkins, N, 2006) |
| "The fixed combination of aspirin, paracetamol (acetaminophen) and caffeine has been used successfully to treat different kinds of pain including migraine attacks." | 3.73 | Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. ( Aicher, B; Akundi, RS; Candelario-Jalil, E; Fiebich, BL; Finkenzeller, G; Heinzmann, M; Hüll, M; Knörle, R; Mantovani, M; Schnierle, P, 2006) |
| "The analgesic and anti-hyperalgesic effects of cannabinoid- and vanilloid-like compounds, plus the fatty acid amide hydrolase (FAAH) inhibitor Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), and acetaminophen, were evaluated in the phenyl-p-quinone (PPQ) pain model, using different routes of administration in combination with opioid and cannabinoid receptor antagonists." | 3.73 | Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice. ( Cichewicz, DL; Haller, VL; Welch, SP, 2006) |
| " The aim of the study was to assess the effect of non-competitive NMDA antagonists and paracetamol (propacetamol) on pain threshold and analgesic potency of this drugs and their combinations in formalin model for pain in rats." | 3.73 | [Dextromethorphan enhances analgesic activity of propacetamol--experimental study]. ( Dobrogowski, J; Przewłocka, B; Wordliczek, J, 2005) |
| " Preterm (< 37 weeks) and term (37-41 weeks) infants received a single dose of propacetamol in the first 24 hours of life when they had minor, painful procedures or as additional treatment in infants receiving opioids." | 3.72 | Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age. ( Allegaert, K; Debeer, A; Devlieger, H; Pluim, MA; Tibboel, D; Van der Marel, CD; Van Lingen, RA; Vanhole, C, 2004) |
| "(1) First-line treatment for both acute and chronic pain is paracetamol or, if necessary, ibuprofen, a nonsteroidal antiinflammatory drug." | 3.72 | Paracetamol + tramadol: new preparation. No advance. ( , 2003) |
| "Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats." | 3.72 | Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats. ( Abelson, KS; Höglund, AU; Kommalage, M, 2004) |
| "To determine whether multiple dosing of acetaminophen would result in drug accumulation in polymedicated elderly patients with rheumatic pain." | 3.71 | Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain. ( Bannwarth, B; Lagrange, F; Le Bars, M; Matoga, M; Maury, S; Palisson, M; Pehourcq, F, 2001) |
| "To compare the hepatic and renal safety profiles of two daily dosage regimens of paracetamol (acetaminophen) (3 g versus 4 g) in patients with painful chronic rheumatoid diseases." | 3.71 | [Liver and renal tolerance to paracetamol: 3 g or 4 g per day?]. ( Ganry, H; Pruvot, F; Schmidely, N; Vesque, D, 2001) |
| " Postoperative pain was treated with morphine (median duration 4 days) or IV paracetamol (5 days)." | 3.71 | [Minimally invasive surgery for diverticula of the thoracic esophagus. Results in 11 patients]. ( Boudet, MJ; Carbonnel, F; Christidis, C; Denet, C; Gayet, B; Godeberge, P; Levard, H; Mal, F; Perniceni, T, 2001) |
| " In acute postoperative pain and chronic pain there is no proof that tramadol has a better risk-benefit ratio than the paracetamol + codeine combination or other step 2 analgesics in the World Health Organisation classification." | 3.70 | Tramadol: new preparation. Capsules: central analgesic; step 2 on the WHO scale. ( , 1998) |
| "Efficacy, tolerability and safety of Dipyrone (Novalgin) in the management of pain and fever in children." | 3.70 | Novalgin in pain and fever. ( Izhar, T, 1999) |
| "Hydrocodone is frequently prescribed in combination with acetaminophen for the relief of pain and has a side effects profile similar to other medications in its class." | 3.70 | Profound hearing loss associated with hydrocodone/acetaminophen abuse. ( Friedman, RA; Gherini, S; House, JW; Luxford, WM; Mills, D, 2000) |
| "(1) This codeine-based syrup is indicated for the treatment of pain in children." | 3.70 | Codeine for child pain: new preparation. Helpful in some cases. ( , 1999) |
| " Attention should be paid to the appearance of side-effects of morphine, the circulation of pain graduation tables and the evaluation of anxiety in this category of patient." | 3.69 | [Treatment of pain and anxiety in terminal oncologic patients in the Castilla-La Mancha community]. ( Calles Gato, MD; Hernández Moreno, J; López de Castro, F; Muñoz González, F; Sánchez del Viso, Y; Sánchez Muñoz, C, 1995) |
| "This retrospective review evaluated the pain management of 395 acutely burned pediatric patients who were treated by a pain management protocol emphasizing acetaminophen as the initial medication to control background pain." | 3.69 | Acetaminophen in the management of background pain in children post-burn. ( Blakeney, PE; Cortiella, J; Herndon, DN; Marvin, JA; Meyer, WJ; Nichols, RJ; Villarreal, C, 1997) |
| " A case of NAS due to codeine prescribed for pain relief during pregnancy is reported." | 3.69 | Neonatal abstinence syndrome due to codeine. ( Chang, J; Khan, K, 1997) |
| "The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat." | 3.68 | Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993) |
| "The traditional "aspirin first" approach to the treatment of osteoarthritis and rheumatoid arthritis is undergoing serious reappraisal." | 3.67 | Pain and inflammation. ( Calin, A, 1984) |
| "The analgesic effects of dextropropoxyphene and paracetamol and that of a combination of the two drugs were assessed in 24 patients who suffered from either rheumatoid arthritis or osteoarthritis." | 3.67 | Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis. ( Cunningham, TJ; Mathews, JD; Mitchell, H; Muirden, KD, 1984) |
| "A comparison was made between the relative effects of aspirin, mefenamic acid, dihydrocodeine , dextropropoxyphene and paracetamol on visceral pain (chemically-inducing writhing), respiratory rate and prostaglandin (PG) biosynthesis (cyclo-oxygenase activity)." | 3.67 | Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis. ( Gonzalez, JP; Pugh, J; Sewell, RD, 1984) |
| "Intrathecally administered substance P (SP) or capsaicin in mice elicited a pain-related behavioral response consisting of vigorous biting, licking and scratching of the caudal part of the body." | 3.67 | Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin. ( Fasmer, OB; Hole, K; Hunskaar, S, 1985) |
| "We studied the time course and intensity of pain of multiple bone marrow aspirations in 30 healthy adult marrow donors receiving acetaminophen with codeine for analgesia immediately after marrow harvesting for allogeneic bone marrow transplantation." | 3.67 | Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation. ( Chapman, CR; Hill, HF; Jackson, TL; Sullivan, KM, 1989) |
| "We studied the effects of two non-steroidal anti-inflammatory analgesics (NSAIAs), acetylsalicylic acid (ASA) and acetaminophen, on sleep patterns in rats with adjuvant-induced arthritis." | 3.67 | Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989) |
| "The effectiveness of nonprescription analgesics--acetaminophen and aspirin--in providing subjective relief of preoperative dental pain was evaluated in a varied population of adults." | 3.66 | Evaluation of acetaminophen and aspirin in the relief of preoperative dental pain. ( Kilkuts, A; Korberly, BH; Orkand, RK; Schreiber, GF; Segal, H, 1980) |
| "Worldwide, cancer pain management follows the World Health Organization (WHO) three-step analgesic ladder." | 3.11 | An international, open-label, randomised trial comparing a two-step approach versus the standard three-step approach of the WHO analgesic ladder in patients with cancer. ( Allende, S; Caraceni, A; Dierberger, K; Fallon, M; Gordon, D; Grant, L; Hall, PS; Kaasa, S; Laird, BJA; Lee, R; Leng, M; McWillams, K; Murray, GD; Norris, L; Reid, C; Sabar, R; Sande, TA; Verastegui, E, 2022) |
| "Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular." | 3.01 | Pharmacokinetic and pharmacodynamic herb-drug interactions of common over-the-counter pain medications. ( Sun, CK; Tsai, TH, 2023) |
| " Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects." | 3.01 | Common Selfcare Indications of Pain Medications in Children. ( Bell, J; Kachroo, P; Mossali, VM; Siddiqui, K; Zempsky, W, 2023) |
| "Pain is one of the most frequently reported experiences amongst children with Juvenile Idiopathic Arthritis (JIA); however, the management of JIA pain remains challenging." | 3.01 | A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis. ( Brandelli, YN; Chambers, CT; Huber, AM; Mackinnon, SP; Parker, JA; Piccolo, O; Stinson, JN; Wildeboer, EM; Wilson, JP, 2023) |
| "Cumulative pain is associated with morbidities, including adverse neurodevelopmental outcomes." | 3.01 | Breastfeeding or breast milk for procedural pain in neonates. ( Shah, PS; Shah, VS; Torgalkar, R, 2023) |
| " Current analgesics have adverse effects." | 3.01 | Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants. ( Banks, P; Boehm, KA; Bundrant, L; Gopinathan, S; Hunt, TL; Kassler-Taub, K; Tyle, P; Warner, C; Wason, S; Wilson, A, 2021) |
| " This trial aims to compare the pharmacokinetic (PK) parameters of paracetomol between the IV and SC routes in PC patients." | 2.94 | Intravenous versus subcutaneous route pharmacokinetics of paracetamol (acetaminophen) in palliative care patients: study protocol for a randomized trial (ParaSCIVPallia). ( Alix, A; Creveuil, C; Gourio, C; Guillaumé, C; Lelong-Boulouard, V; Lepoupet, M; Peyro-Saint-Paul, L; Vernant, M, 2020) |
| " However, further study should be conducted to find the optimal dosage of paracetamol for relieving the pain in amniocentesis along with a large RCT with a long-term follow-up to evaluate the side effects of paracetamol." | 2.87 | Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial. ( Pattanavijarn, L; Sudjai, D; Tuaktaew, T, 2018) |
| "Pain has a negative impact on life satisfaction (LS)." | 2.87 | Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients. ( Kokki, H; Kokki, M; Kuronen, M; Nyyssönen, T; Savolainen, S, 2018) |
| "Un(der)diagnosed and un(der)treated pain is a serious and frequent problem in persons with dementia." | 2.87 | Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial. ( Achterberg, WP; Caljouw, MAA; Gussekloo, J; Husebo, BS; van Dam, PH, 2018) |
| "Pain was assessed with the Premature Infant Pain Profile (PIPP) and the COMFORTneo score." | 2.84 | Randomized Controlled Trial Comparing Different Single Doses of Intravenous Paracetamol for Placement of Peripherally Inserted Central Catheters in Preterm Infants. ( Reiss, IKH; Roofthooft, DWE; Simons, SHP; Tibboel, D; van den Anker, JN; van Dijk, M; van Lingen, RA, 2017) |
| "The pain was scored through a 100-mm visual analog scale (VAS) immediately and 2 h after the procedure." | 2.82 | Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial. ( Abbasi, M; Agah, E; Ahmadi, M; Faghihi-Kashani, S; Kalantar, SS; Majedi, H; Tafakhori, A, 2016) |
| "Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery." | 2.82 | Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels. ( Eberhardt, E; Eberhardt, M; Leffler, A; Schillers, F, 2016) |
| " The objective of this study was to evaluate the effect of a dual-modality (written and spoken) literacy-appropriate educational strategy on patients' knowledge of and safe use of opioid analgesics." | 2.80 | Improving patient knowledge and safe use of opioids: a randomized controlled trial. ( Adams, JG; Ahlstrom, E; Cameron, KA; Chevrier, A; Courtney, DM; Engel, KG; McCarthy, DM; McConnell, R; Sears, J; Wolf, MS, 2015) |
| "Pain was measured using a 10-point visual analog pain scale during probe insertion, during the biopsy procedure, and 1 hour postbiopsy." | 2.80 | Intravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled study. ( Akand, M; Haliloglu, AH; Kilic, O; Kulaksizoglu, H; Piskin, MM; Tanidik, S; Yurdakul, T, 2015) |
| "Sixty patients with nonresectable pancreatic cancer reporting visual analog scale (VAS) ≥ 70 (visceral pain, continuous or intermittent) were randomized into 2 equal groups." | 2.78 | Comparative study between 2 protocols for management of severe pain in patients with unresectable pancreatic cancer: one-year follow-up. ( Amr, YM; Makharita, MY, 2013) |
| "Recent studies have linked patient misunderstanding of label instructions for as needed (PRN) medications to dosing errors." | 2.78 | Take-Wait-Stop: a patient-centered strategy for writing PRN medication instructions. ( Bailey, SC; Davis, TC; Jacobson, KL; King, JP; McCarthy, DM; Mullen, RJ; Parker, RM; Serper, M; Wolf, MS, 2013) |
| "Osteoporotic vertebral compression fractures (VCFs) are a major cause of increased morbidity in older patients." | 2.76 | Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. ( Alibai, E; Farrokhi, MR; Maghami, Z, 2011) |
| "Overall, pharmacokinetic data were roughly comparable with earlier publications, but differences were noted in the subgroup ICU patients." | 2.75 | Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance. ( Brüggemann, RJ; de Maat, MM; Ponssen, HH; Tijssen, TA, 2010) |
| "The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks." | 2.74 | Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. ( Forest, K; Girodet, PO; Jacquet, A; Mallet, L; Moore, N; Pariente, A, 2009) |
| "Acetaminophen (APAP) is a popular analgesic." | 2.73 | Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain. ( Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007) |
| " Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects." | 2.73 | The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. ( Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT, 2007) |
| " The acute pain models were not sufficiently sensitive to detect an analgesic effect of paracetamol or the combination with dextromethorphan." | 2.73 | Effects of paracetamol combined with dextromethorphan in human experimental muscle and skin pain. ( Ali, Z; Arendt-Nielsen, L; Drewes, AM; Olesen, AE; Staahl, C, 2007) |
| "In palliative cancer care, when approaching death, swallowing difficulties and the burden of tablet intake frequently makes us reconsider each individual drug prescribed." | 2.73 | Analgesic effect of paracetamol on cancer related pain in concurrent strong opioid therapy. A prospective clinical study. ( Axelsson, B; Stellborn, P; Ström, G, 2008) |
| " Despite its effectiveness, CDDP might cause severe toxic adverse effects on multiple body organs during cancer chemotherapy, including the kidneys, heart, liver, gastrointestinal tract, and auditory system, as well as peripheral nerves causing severely painful neuropathy." | 2.72 | Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity. ( El-Sheikh, A; Khired, Z, 2021) |
| "We extracted pain and adverse events outcomes from 36 systematic reviews that assessed the efficacy of paracetamol in 44 painful conditions." | 2.72 | The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. ( Abdel Shaheed, C; Ahedi, H; Day, RO; Dmitritchenko, A; Ferreira, GE; Kamper, S; Langendyk, V; Latimer, J; Lin, C; Maher, CG; McLachlan, AJ; McLachlan, H; Saragiotto, B; Stanaway, F, 2021) |
| "Pain was scored using a 1-6 faces scale." | 2.72 | Paediatric cancer pain management using the WHO analgesic ladder--results of a prospective analysis from 2265 treatment days during a quality improvement study. ( Andler, W; Hasan, C; Jorch, N; Michel, E; Smale, H; Zernikow, B, 2006) |
| "Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention." | 2.72 | Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. ( Brandt, KD; Buckwalter, KA; Mazzuca, SA, 2006) |
| "In addition to providing acute postoperative pain relief, preoperative PVB seems to reduce the prevalence of chronic pain 1 yr after breast cancer surgery." | 2.72 | Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. ( Bachmann, MS; Kairaluoma, PM; Pere, PJ; Rosenberg, PH, 2006) |
| "Naproxen and ibuprofen were more effective than acetaminophen in minimizing physical side effects of IFN beta-1a." | 2.71 | A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. ( Filipi, M; Healey, K; Leuschen, MP, 2004) |
| " Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited." | 2.71 | Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005) |
| "Pain was related to an infection in 98% of the cases." | 2.70 | [Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol]. ( Bernard-Fernier, MF; Cabane, J, 2001) |
| "Changes in menstrual pain intensity and duration, amount of bleeding measured according to the number of daily pads used and concomitant symptoms were assessed on the fifth day of each cycle." | 2.70 | Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial. ( de los Santos, AR; Di Girolamo, G; Martí, ML; Pérez Macri, S; Zmijanovich, R, 2001) |
| "CR codeine treatment resulted in significantly lower overall VAS pain intensity scores (35 +/- 18 vs." | 2.68 | Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial. ( Arkinstall, W; Babul, N; Darke, AC; Goughnour, B; Harsanyi, Z; Sandler, A, 1995) |
| " Tolerance in terms of withdrawals or side-effect profile did not appear to the dosage of each preparation administered." | 2.67 | The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips. ( Costello, F; Eves, MJ; James, IG; Lloyd, RS; Miller, AJ, 1992) |
| "Peak analgesia was reached after 2 h." | 2.67 | Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol. Double blind, placebo-controlled evaluation using painful laser stimulation. ( Arendt-Nielsen, L; Bjerring, P; Nielsen, JC; Petterson, KJ, 1992) |
| "Nimesulide was studied in comparison with paracetamol, according to a double-blind technique." | 2.67 | Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories. ( D'Apuzzo, V; Monti, T, 1992) |
| "It was confirmed that headache as a pain model does not show the usual return of pain with as the effects of a single analgesic dose wear off." | 2.67 | Evaluation of analgesic agents in recurring headache compared with other clinical pain models. ( Aimola, N; Gawel, MJ; Stiglick, A; Szalai, JF; Weiner, M, 1990) |
| "Acute soft tissue injuries are common and costly." | 2.66 | Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. ( Dalziel, SR; Jones, P; Lamdin, R, 2020) |
| "The rate of pregnant women with an opioid use disorder has risen drastically in the past 20 years, paralleling that in the general population." | 2.66 | Opioid Use and Misuse in Pregnancy. ( Landau, R; Shatil, B, 2020) |
| " The two drugs were found to have the same efficiency on the subjective parameters but high bioavailability glaphenine seems to have an effectiveness in the range of articulatory movements, which is not found with paracetamol." | 2.66 | Comparative study of high bio-availability glaphenine and paracetamol in cervical and lumbar arthrosis. ( Albert, A; Crielaard, JM; Franchimont, P; Urbin Choffray, D, 1987) |
| "Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine." | 2.66 | Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986) |
| "Pain was assessed prior to treatment, at 48 hours, and at one month using a visual analog scale." | 2.66 | Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain. ( Ordog, GJ, 1987) |
| " Patients were allocated at random to receive 2 tablets 3-times daily of either treatment for 6 weeks and were then crossed over to the alternative treatment at the same dosage for a further 6 weeks." | 2.65 | Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis. ( Boston, PF; Matts, SG, 1983) |
| " Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months." | 2.64 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974) |
| "Pain was more commonly reported by informal caregivers than the person with dementia themselves." | 2.61 | Pain assessment and pain treatment for community-dwelling people with dementia: A systematic review and narrative synthesis. ( Bartlam, B; Bedson, J; Bullock, L; Campbell, P; Chew-Graham, CA; Jordan, JL, 2019) |
| "Pain is an unpleasant side-effect that can be experienced during orthodontic procedures including debonding of fixed appliances." | 2.61 | Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review. ( Alharbi, F; Almuzian, M; Alomari, S; Mohammed, H; Rizk, MZ; Ulhaq, A, 2019) |
| "Pain during pregnancy is common, and its management is complex." | 2.61 | Medication Use and Pain Management in Pregnancy: A Critical Review. ( Black, E; Chutatape, A; Demirkol, A; Kennedy, D; Khor, KE; Sharma, S; Vancaillie, T, 2019) |
| " Given that these drugs also can modulate tissue protein turnover, it is important to scrutinize the implications of acute and chronic use of these drugs in relation to exercise performance and the development of long-term training adaptations." | 2.58 | Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations. ( Howatson, G; Lundberg, TR, 2018) |
| " This article presents different analgesic drugs, their mode of action, indications, dosage and adverse drug reactions." | 2.58 | [Pharmacological Basis of Pain Treatment]. ( Schüning, J; Schwarzer, A, 2018) |
| " The level of certainty for dosing recommendations obtainable from reviewing the evidence is low due to a small number of studies meeting search criteria, small samples sizes, inadequate information regarding cirrhosis etiology and compensated versus uncompensated liver disease, and lack of information on patient centered health outcomes." | 2.58 | A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease. ( Juba, KM; Schweighardt, AE, 2018) |
| " A variety of dosing regimens is therefore used off-label." | 2.55 | Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree. ( Allegaert, K; Calvier, EAM; Knibbe, CAJ; Mian, P; Tibboel, D, 2017) |
| "Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes." | 2.55 | Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017) |
| " Only pCGS is given as a highly bioavailable once daily dose (1500 mg) with a proven pharmacological effect." | 2.53 | A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes. ( Bruyère, O; Cooper, C; Kovalenko, V; Kucharz, EJ; Reginster, JY; Szántó, S, 2016) |
| "Fear of dental pain is a major barrier to treatment for children who need dental care." | 2.53 | Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. ( Anand, P; Ashley, PF; MacDonald, LC; Moles, DR; Parekh, S, 2016) |
| "Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States." | 2.52 | Intravenous acetaminophen use in pediatrics. ( Shastri, N, 2015) |
| " The evidence was usually either low quality or very low quality, reflecting study limitations, indirectness such from as suboptimal dosing of single comparators, imprecision, or one or more of these." | 2.52 | Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. ( Dalziel, SR; Frampton, C; Jones, P; Lamdin, R; Miles-Chan, JL, 2015) |
| " Dosage reduction and/or increased dose interval are often required." | 2.52 | [Analgesia in patients with hepatic impairment]. ( Innaurato, G; Piguet, V; Simonet, ML, 2015) |
| " Analgesic requirements are influenced by age-related changes in both pharmacokinetic and pharmacodynamic response, and increasing data are available to guide safe and effective dosing with opioids and paracetamol." | 2.50 | Neonatal pain. ( Walker, SM, 2014) |
| "His pain was scored as a five on a six-point visual analog scale, and it persisted despite routine supportive therapy." | 2.50 | [A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl]. ( Anzai, S; Hashimoto, Y; Nagasawa, K; Suzuki, T, 2014) |
| "Appropriate treatment of pain requires an understanding of the characteristics of pain, including the severity and the nature of the pain-for example, acute versus chronic pain or nociceptive versus neuropathic pain." | 2.49 | An overview of pain management: the clinical efficacy and value of treatment. ( Nalamachu, S, 2013) |
| "Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev." | 2.48 | Acetaminophen injection: a review of clinical information including forms not available in the United States. ( Beckwith, MC; Fox, ER; Jones, VM, 2012) |
| "Fear of dental pain is a major barrier to children needing dental care." | 2.48 | Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. ( Anand, P; Ashley, PF; Behbehani, A; Moles, DR; Parekh, S, 2012) |
| "The pain experienced by cancer patients can be managed in 70-90% of cases by the World Health Organisation protocol for cancer pain." | 2.47 | [Solutions for the clinical problems of analgesics for cancer pain treatment in Japan]. ( Kokubun, H; Matoba, M; Yago, K; Yamada, Y, 2011) |
| "Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev." | 2.47 | Acetaminophen injection: a review of clinical information. ( Jones, VM, 2011) |
| " In general, acetaminophen at reduced dosing is a safe option." | 2.46 | Pain management in the cirrhotic patient: the clinical challenge. ( Chandok, N; Watt, KD, 2010) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 2.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| " NSAIDs are typically more effective than acetaminophen; however, because of adverse effects associated with long-term use of NSAIDS, acetaminophen is considered first-line therapy." | 2.45 | Osteoarthritis: a review of treatment options. ( Dunican, KC; Lynch, AM; Seed, SM, 2009) |
| "Tramadol seems to be a potential useful analgesic for term neonates and infants, but has limited indications in (extreme) preterm neonates." | 2.44 | Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. ( Allegaert, K; de Hoon, J; Naulaers, G; Van De Velde, M, 2008) |
| " Referring to the current debate, potential mechanisms underlying cardiovascular side effects associated with long-term use of COX inhibitors are discussed." | 2.44 | Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolinones. ( Brune, K; Hinz, B, 2007) |
| "She is open to other therapeutic approaches and wants to know if acupuncture can help the pain, improve function, and stop her condition from progressing." | 2.44 | A 60-year-old woman considering acupuncture for knee pain. ( Berman, B, 2007) |
| "A time delay exists before drug reaches the effect compartment, and the equilibration half-time between the central and effect compartment is described by a single first-order parameter (Teq or T(1/2)keo), reported to be approximately 1 h for paracetamol." | 2.44 | Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration. ( Anderson, BJ; Gibb, IA, 2008) |
| "Acetaminophen is a safe medication that should be considered first-line therapy." | 2.44 | Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? ( Choquette, D; Craig, BN; Davis, P; De Angelis, C; Fulthorpe, G; Habal, F; Hunt, RH; Stewart, JI; Turpie, AG, 2007) |
| "Pain is an unpleasant sensation that originates from ongoing or impending tissue damage." | 2.44 | Recent advances in the pharmacological management of pain. ( Beaulieu, P; Guindon, J; Walczak, JS, 2007) |
| "Clinicians treating pain should be familiar with the actions, adverse effects, and individual agents in the group of nonopioid analgesics." | 2.44 | Nonopioid analgesics. ( Enany, N; Munir, MA; Zhang, JM, 2007) |
| "NSAIDs are widely applied to treat cancer pain and are frequently combined with opioids in combination preparations for this purpose." | 2.43 | NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. ( Carr, DB; Goudas, L; Lau, J; McNicol, E; Strassels, SA, 2005) |
| "Valdecoxib also has superior gastrointestinal safety compared with nonspecific nonsteroidal anti-inflammatory drugs, and at therapeutic doses, it is generally safe and well tolerated in terms of renal and cardiovascular events." | 2.43 | Valdecoxib for the management of chronic and acute pain. ( Joshi, GP, 2005) |
| "Pain is one of the most common reasons patients seek dental treatment." | 2.43 | Drugs for pain management in dentistry. ( Abbott, PV; Hargreaves, K, 2005) |
| " Dosing of both drug groups is tempered by concerns about toxicity." | 2.43 | Pain control: non-steroidal anti-inflammatory agents. ( Anderson, BJ; Jacqz-Aigrain, E, 2006) |
| " Major concerns in long-term use of anti-inflammatory drugs include renal toxicity, gastrointestinal ulceration and bleeding and cardiovascular events, which can be of particular concern for elderly patients." | 2.43 | Pharmacological aspects of successful long-term analgesia. ( Raffa, R, 2006) |
| " The review establishes that aspirin, paracetamol and ibuprofen are safe in OTC doses and that there is no evidence for any difference between the medicines as regards efficacy and safety for treatment of colds and flu (except in certain cases such as the use of aspirin in feverish children)." | 2.43 | Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. ( Eccles, R, 2006) |
| " Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease." | 2.43 | Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006) |
| "Chronic pain has a growing incidence with age." | 2.43 | [Management strategies for the treatment of non malignant chronic pain in the elderly]. ( Perrot, S, 2006) |
| "Persons with advanced CKD and ESRD are at increased risk for adverse effects of analgesic agents because of enhanced drug sensitivity, comorbid conditions, and concurrent medication use." | 2.42 | Analgesia in patients with ESRD: a review of available evidence. ( Bennett, WM; Chertow, GM; Kurella, M, 2003) |
| " Although the bioavailability of paracetamol is not impaired in patients with chronic, benign liver diseases, the agent is contraindicated in those with hepatic insufficiency." | 2.42 | [Pharmacologic basis for using paracetamol: pharmacokinetic and pharmacodynamic issues]. ( Bannwarth, B; Péhourcq, F, 2003) |
| " Better dosage forms are also required for rectal administration." | 2.42 | [New perspectives on paracetamol]. ( Prescott, LF, 2003) |
| "Pain is a common reason to attend hospital but it is often inadequately managed." | 2.42 | Pharmacological techniques for managing acute pain in emergency departments. ( Butcher, D, 2004) |
| "Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day." | 2.42 | Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004) |
| "Codeine is an opiate with uncertain and unpredictable effects." | 2.42 | [Problem forte--is paracetamol-codeine combination rational?]. ( Helland, A; Slørdal, L; Spigset, O, 2004) |
| "The standard pillar of postoperative treatment of severe pain is the use of opioids." | 2.41 | Non-opioid postoperative analgesia. ( Dahl, V; Raeder, JC, 2000) |
| "If untreated, the pain of circumcision causes both short and long term changes in infant behaviours." | 2.41 | Pain management for neonatal circumcision. ( Taddio, A, 2001) |
| " In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury." | 2.41 | Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000) |
| "Pain is a significant problem in many patients with genitourinary malignancy at all stages of disease." | 2.41 | Update on pain management for advanced genitourinary cancer. ( Harrison, P, 2001) |
| "Pain is the most prominent symptom and clinical finding in osteoarthritis (OA)." | 2.41 | Treatment of chronic pain in osteoarthritis: do opioids have a clinical role? ( Lipman, AG, 2001) |
| "Pyoderma gangrenosum is used as the basis for applying the new pain standards." | 2.41 | Pyoderma gangrenosum: a case study for pain management in dermatology nursing. ( Dunwoody, CJ; McCann, SA; Zumbo, M, 2000) |
| " During repeated dosage with the specific COX-2 inhibitors, the 24 hour urinary excretion of sodium is only inhibited for the first day of treatment while the excretion of sodium is still decreased over the first 3 hours after the individual doses." | 2.41 | Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). ( Day, RO; Graham, GG; Graham, RI, 2002) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| ") After initiating morphine or making any change of dose or route of administration, the dosage should be evaluated after approximately 24 hours." | 2.40 | The management of chronic pain in patients with breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Society of Palliative Care Physicians. Canadian Association of Radiation Oncologist ( , 1998) |
| "Chronic pain affects 75 million US citizens." | 2.40 | Non-NSAID pharmacologic treatment options for the management of chronic pain. ( Schnitzer, TJ, 1998) |
| "Data on assessment and treatment of spinal cord compression are reviewed." | 2.40 | Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. ( Abrahm, JL, 1999) |
| "Acetaminophen is a suitable substitute for aspirin for its analgesic or antipyretic uses in patients in whom aspirin is contraindicated (e." | 2.39 | Acetylsalicylic acid and acetaminophen. ( Kacso, G; Terézhalmy, GT, 1994) |
| "Acetaminophen is a safe antipyretic therapy prescribed in children." | 2.39 | [Paracetamol and other antipyretic analgesics: optimal doses in pediatrics]. ( Stamm, D, 1994) |
| "Pain is a common and complex problem in the geriatric population." | 2.39 | Pain management for the geriatric patient. ( Forman, WB; Roche, RJ, 1994) |
| " In general, dosage escalation and compulsive drug-seeking behaviors were not seen." | 2.38 | Pharmacologic management of pain in children and adolescents. ( Berde, CB; Shannon, M, 1989) |
| "Acetaminophen is an effective antipyretic and analgesic with few side effects that is toxic only in massive overdose." | 2.36 | Use of antipyretic analgesics in the pediatric patient. ( Gladtke, E, 1983) |
| "Aspirin has some advantage over acetaminophen for analgesia." | 2.36 | Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity. ( Lovejoy, FH, 1978) |
| "Pain is common among cirrhosis patients, particularly those hospitalized with acute illness." | 1.91 | Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis. ( Auerbach, A; Hohmann, SF; Lai, JC; Rubin, JB; Shui, AM, 2023) |
| "Inflammatory pain is part of the body's defense mechanism and plays an important role in the healing process." | 1.91 | Modulation of inflammatory mediators involved in the antinociceptive and anti-inflammatory effects of a new thioamide derivative: thiocyanoacetamide. ( Ben Akacha, A; Ben Ali, R; Ben Othman, A; El May, MV, 2023) |
| " Pharmacokinetic parameters for the parent compound were estimated with a nonlinear mixed-effects model." | 1.91 | Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study. ( Avachat, C; Barry, JM; Birnbaum, AK; Brink Henriksen, T; Christensen, U; Dalhoff, K; Haslund-Krog, S; Holst, H; Poulsen, S; Remmel, RP; Sherwin, CMT; van den Anker, JN; Wilkins, D, 2023) |
| "The origin of pain is likely neuropathic." | 1.91 | Mpox Pain Management with Topical Agents: A Case Series. ( Bugayong, ML; DeVita, MA; Shabbir, M, 2023) |
| "The characteristics of cervicogenic headache were summarized, the numerical rating score (NRS) of patients before and after treatment of compound opioids and/or cervical nerve block was compared, and the occurrence of related adverse reactions and complications was counted." | 1.91 | [Clinical characteristics and therapeutic effectiveness of post craniotomy cervicogenic headache]. ( Huang, Y; Luo, F; Meng, L; Zhou, R, 2023) |
| " Antinociception was assessed by dose-response curves to paracetamol and meloxicam before and after the i." | 1.72 | Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2022) |
| " A two-compartment pharmacokinetic model with first-order elimination described disposition for both drugs." | 1.72 | Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers. ( Anderson, BJ; Atkinson, HC; Morse, JD; Stanescu, I, 2022) |
| "In dentistry, pain is a rather inevitable perception that often plagues both the care provider and receiver." | 1.72 | Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study. ( Kaarthikeyan, G; Murthykumar, K; Rajasekar, A, 2022) |
| "Ketorolac was not associated with increased risk of postoperative bleeding (0." | 1.72 | Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort. ( Bowman, A; Brant, A; Johnson, JP; Lewicki, P; Shoag, JE; Sze, C; Weinstein, IC, 2022) |
| "Pain is a major problem that burdens the health and economy of societies worldwide." | 1.72 | Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats. ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022) |
| "Legg-Calvé-Perthes disease (LCPD) and slipped capital femoral epiphysis (SCFE) can result in painful deformation of the hip joint with impaired range of motion and early development of secondary osteoarthritis." | 1.72 | Pediatric Hip Disease Increases the Risk for Opioid Use in Adulthood: Long-term Burden of Pain and Depression. ( Hailer, YD; Wadström, MG, 2022) |
| "Pain was assessed using the Mobilization-Observation-Behavior-Intensity-Dementia-2 (MOBID-2) Pain Scale." | 1.72 | Prevalence and persistent prescription of analgesic drugs in persons admitted with dementia to a nursing home - A longitudinal study. ( Bergh, S; Helvik, AS; Husebø, B; Kabukcuoğlu, K; Lichtwarck, B; Šaltytė Benth, J; Tevik, K, 2022) |
| "Pain is one of the most common and debilitating symptoms of hidradenitis suppurativa (HS)." | 1.72 | Pain management modalities for hidradenitis suppurativa: a patient survey. ( Borgstrom, M; Fernandez, JM; Hsiao, JL; Orenstein, LAV; Shi, VY; Thompson, AM, 2022) |
| "Pain is highly prevalent among older people, and treatment is complicated because of comorbidities and polypharmacy." | 1.62 | Pharmacological Pain Treatment in 2012 and 2017 Among Older People with Major Neurocognitive Disorder. ( Gustafsson, M; Lövheim, H; Sjölander, M, 2021) |
| " Overall, these systems could significantly enhance the bioavailability of paracetamol and prolong its therapeutic effect in numerous diseases such as cold, flu, COVID-19, and severe pain." | 1.62 | Overcoming the paracetamol dose challenge with wrinkled mesoporous carbon spheres. ( Ejsmont, A; Galarda, A; Goscianska, J; Olejnik, A; Wuttke, S, 2021) |
| "Women with preeclampsia had used significantly more often paracetamol during pregnancy compared to controls (cases 8." | 1.62 | Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence? ( Keski-Nisula, L; Sahlman, H; von Hellens, H, 2021) |
| "Pain is a common but often ignored symptom in COVID-19 patients." | 1.62 | COVID-19'da İhmal Edilen Semptom: Ağrı. ( Sir, E, 2021) |
| "Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs)." | 1.62 | Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis. ( Doherty, M; Lei, G; Persson, MSM; van Middelkoop, M; Wei, J; Xiong, Y; Zeng, C; Zhang, W, 2021) |
| "Childhood burns are common and distressing for children and their parents." | 1.56 | Pain Management for Pediatric Burns in the Outpatient Setting: A Changing Paradigm? ( Bielsky, A; Goldsmith, A; Meier, M; Moulton, S; Phillips, R; Recicar, J; Shahi, N; Shirek, G; Yaster, M; Zuk, J, 2020) |
| "Pain is a hallmark of this condition and can be extremely difficult to control." | 1.56 | Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020) |
| "Endometriosis is characterized by abdominopelvic hypersensitity." | 1.51 | Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis. ( Awaga, Y; Hama, A; Hayashi, I; Matsuda, A; Natsume, T; Ogawa, S; Takamatsu, H; Yano, M, 2019) |
| "Pain is a common and distressing symptom of pediatric cancer, as reported by both children and their parents." | 1.48 | Pain in Children With Cancer: Prevalence, Characteristics, and Parent Management. ( Barwick, M; Campbell, F; Chambers, CT; Fernandez, CV; Irwin, K; Jibb, LA; Nathan, PC; Parker, JA; Stinson, JN; Tutelman, PR; Witteman, HO, 2018) |
| "Placebo effects on pain have been found to vary in size for different routes of medication administration (e." | 1.48 | Expectations about the effectiveness of pain- and itch-relieving medication administered via different routes. ( Evers, AWM; Peerdeman, KJ; Peters, ML; Rippe, RCA; Tekampe, J; van Laarhoven, AIM; van Middendorp, H, 2018) |
| " The intake frequency and dosage of Paracetamol varied between the women and was overall low with a tendency towards higher frequencies and higher dosages in the third trimester." | 1.46 | Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort. ( Arck, PC; Becher, H; Bremer, L; Diemert, A; Gehbauer, C; Goletzke, J; Hecher, K; Pagenkemper, M; Tiegs, G; Tolosa, E; Wiessner, C, 2017) |
| "Routine oral dosing practices in a SSA hospital resulted in substantial underexposure to paracetamol." | 1.46 | Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study. ( Bos, JC; Mathôt, RAA; Mistício, MC; Nunguiane, G; Prins, JM; van Hest, RM, 2017) |
| "Acetaminophen was administered 2." | 1.46 | Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. ( Moody, MA; Saleh, E; Swamy, GK; Walter, EB, 2017) |
| "Morphine dosage was calculated as the cumulative dose administered during the neonatal intensive care unit period." | 1.43 | Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants. ( Aikio, O; Hallman, M; Härmä, A; Saarela, T, 2016) |
| "Meperidine was applied to animals with increasing doses and their tail flick latencies (TFL) were noted at 20, 40, 60, 90, 120, 180, and 240 min." | 1.43 | Combination of paracetamol or ketamine with meperidine enhances antinociception. ( Akkar, OB; Cetin, A; Cetin, M; Gulturk, S; Kula, A, 2016) |
| " For residents with scheduled medication, dosage and duration of use were analysed." | 1.43 | Pain medication in German nursing homes: a whole lot of metamizole. ( Hoffmann, F; Schmiemann, G, 2016) |
| "Acetaminophen was discontinued and IV acetylcysteine was given and continued at the second maintenance dose rate for a second 16-hour infusion, at which time transaminases, INR, ammonia and total bilirubin were all improving." | 1.43 | Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen. ( Anderson, VE; Dart, RC; Green, JL; Heard, KJ; Kovnat, D; Seifert, SA, 2016) |
| "Acetaminophen was administered at a dose of 600 mg (14." | 1.43 | Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs. ( KuKanich, B, 2016) |
| " IV and PO APAP doses administered with a predose pain score ≥4 within 1 h of dosing were compared." | 1.43 | Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. ( Brophy, GM; Nadpara, PA; Nichols, DC; Taylor, PD, 2016) |
| "Pain is a major problem in all cancer stages." | 1.42 | Adaptation of an evidence-based clinical practice guideline in cancer pain management by medical oncologists: a case vignette study. ( Besse, K; Engels, Y; te Boveldt, N; Vernooij-Dassen, M; Vissers, K, 2015) |
| " Ten percent of literate respondents were unable to understand the dosage requirements for children." | 1.42 | "But it's just paracetamol": Caregivers' ability to administer over-the-counter painkillers to children with the information provided. ( Bennin, F; Rother, HA, 2015) |
| "Although daytime sleepiness occurred in a large number of residents, especially those with dementia, this sleepiness was not necessarily associated with use of opioids." | 1.42 | Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities. ( Bell, JS; Emery, T; Hilmer, SN; Hughes, JM; Ilomäki, J; Jones, MJ; Moawad, S; Quirke, T; Robson, L; Tan, EC; Visvanathan, R; Vitry, AI, 2015) |
| "Acute dental pain is a recognised precipitant of unintentional paracetamol overdose and in a small but significant number of cases this results in hepatotoxicity." | 1.40 | Identifying adults at risk of paracetamol toxicity in the acute dental setting: development of a clinical algorithm. ( Byers, J; Marney, C; Nayyer, NV, 2014) |
| "Additionally, areas of flare and secondary hyperalgesia were mapped, and time course of hyperalgesia determined." | 1.40 | An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. ( Henrich, F; Jürgens, TP; Magerl, W; May, A; Sawatzki, A, 2014) |
| "Pain is the presenting symptom in 20 to 30% of patients with autosomal dominant polycystic kidney disease (ADPKD) and occurs in 50 to 60% of patients at some stage of the disease process, but its frequency increases with age and size of the cysts." | 1.40 | Pain in renal disease. ( Santoro, D; Satta, E, 2014) |
| "Pain is a common symptom associated with cancer and its treatment." | 1.39 | Adult cancer pain. ( Abernethy, AP; Anghelescu, DL; Benedetti, C; Buga, S; Cleeland, C; Deleon-Casasola, OA; Dwyer, M; Eilers, JG; Ferrell, B; Green, M; Janjan, NA; Kamdar, MM; Kumar, R; Levy, MH; Lynch, M; McDowell, RM; Moryl, N; Nesbit, SA; Paice, JA; Rabow, MW; Swarm, RA; Syrjala, KL; Urba, SG; Weinstein, SM, 2013) |
| "Acetaminophen (paracetamol) is a widely used analgesic, but its sites and mechanisms of action remain incompletely understood." | 1.39 | Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. ( Liu, J; Reid, AR; Sawynok, J, 2013) |
| " Paracetamol (acetaminophen in North America) has better bioavailability when given intravenously than orally and has been successfully used in the postoperative care of orthopedic patients." | 1.39 | Can intravenous paracetamol reduce opioid use in preoperative hip fracture patients? ( Mackenney, P; Page, J; Tsang, KS, 2013) |
| "FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety." | 1.39 | Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology. ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013) |
| "Acetaminophen itself was not toxic to developing mouse cortical neurons at therapeutic concentrations of 10-250 μg/ml." | 1.38 | Effects of the analgesic acetaminophen (Paracetamol) and its para-aminophenol metabolite on viability of mouse-cultured cortical neurons. ( DeSilva, M; Gu, TT; Qiang, M; Schultz, S; Whang, K, 2012) |
| "Pain is a prominent symptom in radiotherapy-induced oral mucositis (OM)." | 1.37 | Individualized pharmacological treatment of oral mucositis pain in patients with head and neck cancer receiving radiotherapy. ( Larsson, B; Ling, IS, 2011) |
| "The aim of the study was to analyze factors predicting pain relief and adverse events in patients receiving opioids for acute pain in a prehospital setting." | 1.37 | Predictors of pain relief and adverse events in patients receiving opioids in a prehospital setting. ( Barniol, C; Bounes, V; Ducassé, JL; Houze-Cerfon, CH; Minville, V, 2011) |
| "In a rat incision model of postoperative thermal hyperalgesia, coadministration of nefopam at a non-analgesic dose (3 mg/kg) with paracetamol at a low analgesic dose (300 mg/kg) showed the appearance of a strong antihyperalgesic effect, maintained for at least 3 h." | 1.37 | Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. ( Coppé, MC; Girard, P; Niedergang, B; Pansart, Y; Verleye, M, 2011) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 1.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "A population pharmacokinetic analysis of 943 paracetamol observations from 158 neonates (27-45 weeks' postmenstrual age (PMA)) was undertaken using non-linear mixed effects models." | 1.37 | The pharmacokinetics of intravenous paracetamol in neonates: size matters most. ( Allegaert, K; Anderson, BJ; Palmer, GM, 2011) |
| "Important levels of fatigue are common in knee and hip OA patients." | 1.37 | Fatigue in knee and hip osteoarthritis: the role of pain and physical function. ( Arts-Sanders, MA; Defoort, KC; den Broeder, AA; Fransen, J; Snijders, GF; Stukstette, MJ; van den Ende, CH; van den Hoogen, FH; van Riel, PL, 2011) |
| "Pain is among the most frequent and distressing symptoms in terminally-ill cancer and, to date, many patients still experience uncontrolled pain." | 1.37 | [Pain assessment in terminally-ill cancer patients on admission in hospice and its modification after the first three days of care. A monocentric experience]. ( Bordin, F; D'Addario, ME; Di Miele, D; Fava, A; Ferraccioli, A; Lanzetta, G; Ranucci, A; Rozzi, A; Salerno, M; Scirocchi, R; Terzoli, L, 2011) |
| " Adoption of these two recommendations may lead to the increased use of NSAIDs with the potential of increasing incidence of NSAIDs-related adverse reactions." | 1.36 | FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable? ( Day, RO; Graham, GG; Graudins, A; Mohamudally, A, 2010) |
| "Pain was much more prevalent among our CKD compared with non-CKD patients." | 1.36 | Pain prevalence in patients with chronic kidney disease. ( Dewar, K; Hashmi, S; Pham, PA; Pham, PC; Pham, PM; Pham, PT; Toscano, E, 2010) |
| "Oral acetaminophen was the most commonly prescribed medication (131 patients, 62." | 1.36 | Triage pain scales cannot predict analgesia provision to pediatric patients with long-bone fracture. ( Chang, YC; Lin, YJ; Weng, YM, 2010) |
| "Dysmenorrhea was more prevalent among nutrition and psychology students than among medicine, pharmacy and dentistry students (p<0." | 1.36 | Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. ( Ortiz, MI, 2010) |
| "Acetaminophen is an analgesic and antipyretic drug believed to exert its effect through interruption of nociceptive processing." | 1.35 | Acetaminophen prevents hyperalgesia in central pain cascade. ( Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL, 2008) |
| "Thermal hyperalgesia was also decreased by intraplantar treatment with morphine (10 microg) or diclofenac (100 microg)." | 1.35 | Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat. ( Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J, 2009) |
| "Dextropropoxyphene is a weak opioid analgesic, widely used as a step 2 analgesic (according to WHO classification) in combination with peripheral analgesics, mainly paracetamol." | 1.35 | Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption. ( Damase-Michel, C; Gaubert, S; Montastruc, JL; Pathak, A; Vié, M, 2009) |
| " Over 80% of total daily dosing from age 36 weeks PCA to 1 year fell within dosing suggested by pharmacokinetic studies." | 1.35 | Survey of i.v. paracetamol (acetaminophen) use in neonates and infants under 1 year of age by UK anesthetists. ( Morton, NS; Wilson-Smith, EM, 2009) |
| "Evaluate the efficiency of the treatment of pain by analgesic according to World Health Organization (WHO)." | 1.35 | [Treatment of sickle cell pain]. ( Coulibaly, Y; Dembele, A; Diakite, AA; Dicko-Traore, F; Keita, MM; Sidibe, T; Sylla, M; Togo, B; Traore, B, 2009) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline." | 1.35 | Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008) |
| "Trigeminal neuralgia is a condition which often can be diagnosed on the basis of the clinical history and the specific symptoms." | 1.35 | [Atypical pain in the mandible caused by trigeminal neuralgia]. ( Griëntschnig, CG; Scheltens, P; van der Waal, I, 2008) |
| " The survey showed a wide variation in morphine and paracetamol dosing and the absence of a paracetamol loading dose in a fourth of the units." | 1.35 | Pain management in Swedish neonatal units--a national survey. ( Eriksson, M; Gradin, M, 2008) |
| "He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated." | 1.34 | Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007) |
| "Thermal hyperalgesia was induced by mild heat injury (51 degrees C water for 20 s) which led to a 7-8 degrees C decrease of the noxious heat threshold." | 1.34 | Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. ( Bölcskei, K; Horváth, D; Petho, G; Szolcsányi, J, 2007) |
| "Although acute pain is frequently reported by patients admitted to the emergency room, it is often insufficiently evaluated by physicians and is thus undertreated." | 1.34 | Acute pain in adults admitted to the emergency room: development and implementation of abbreviated guidelines. ( Blanc, C; Buclin, T; Decosterd, I; Givel, JC; Hugli, O; Mouhsine, E; Tamchès, E; Yersin, B, 2007) |
| "Immunization pain is a global public health issue." | 1.34 | Routine immunization practices: use of topical anesthetics and oral analgesics. ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007) |
| "To describe the treatment of knee pain in older adults in primary care and to compare reported practice with published evidence." | 1.34 | Primary care treatment of knee pain--a survey in older adults. ( Croft, P; Jinks, C; Jordan, K; Porcheret, M, 2007) |
| " Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol." | 1.34 | Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007) |
| "Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated or chronic phase, and also for advanced gastrointestinal stromal tumors." | 1.34 | Imatinib-induced fatal acute liver failure. ( Cacchione, R; Gadano, AC; Mandó, OG; Marciano, S; Ridruejo, E; Villamil, AG, 2007) |
| "In elderly persons, pain is a common problem, and analgesic medicines are among the most frequently used drugs." | 1.33 | Balancing pain and analgesic treatment in the home-dwelling elderly. ( Hartikainen, SA; Louhivuori-Laako, KA; Mäntyselkä, PT; Sulkava, RO, 2005) |
| "Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase." | 1.33 | Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice. ( Choi, SS; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW, 2005) |
| "Ibuprofen based drugs were the most frequently used OTC in both surveys (57% Roper, 33% NCL)." | 1.33 | Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs. ( Cryer, B; Triadafilopoulos, G; Wilcox, CM, 2005) |
| "However, if pain is unmanageable in the outpatient department, we believe that options include hospital admission, using the contained method of application or, in the worst case scenario, cessation of treatment." | 1.33 | Determining pain levels in patients treated with maggot debridement therapy. ( Budding, T; Oskam, J; Steenvoorde, P, 2005) |
| " The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID." | 1.33 | Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. ( Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2006) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "In aggregate, 2195 patients (31% with cancer diagnoses per the International Classification of Diseases, Ninth Revision, Clinical Modification) received oxycodone/acetaminophen for more than 9 months at a mean prescribed daily dose of 3." | 1.32 | Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. ( Fiore, LD; Gagnon, DR; Hermos, JA; Young, MM, 2004) |
| "Nonpharmacologic approaches such as cognitive-behavioral therapy, education, osteopathic manipulative treatment, and exercise should be applied in addition to pharmacologic therapy." | 1.31 | Pain management in the elderly. ( Cavalieri, TA, 2002) |
| "The NCCN Cancer Pain Practice Guidelines Panel believes that cancer pain can be well controlled in the vast majority of patients if the algorithms presented are systematically applied, carefully monitored, and tailored to the needs of the individual patient." | 1.31 | NCCN Practice Guidelines for Cancer Pain. ( Benedetti, C; Brock, C; Cleeland, C; Coyle, N; Dubé, JE; Ferrell, B; Hassenbusch, S; Janjan, NA; Lema, MJ; Levy, MH; Loscalzo, MJ; Lynch, M; Muir, C; O'Neill, A; Oakes, L; Payne, R; Syrjala, KL; Urba, S; Weinstein, SM, 2000) |
| "The diagnosis of idiopathic plantar hidradenitis was considered, and then confirmed in one case by plantar biopsy." | 1.31 | [Eccrine neutrophilic hidradenitis: idiopathic plantar form in children]. ( David, L; Erro-Vincent, T; Fouilhoux, A; Kanitakis, J; Souillet, AL, 2001) |
| "The pain was measured by using a visual analog scale (VAS)." | 1.31 | Pain experience during transvaginal aspiration of immature oocytes. ( Hildebrandt, NB; Høst, E; Mikkelsen, AL, 2001) |
| "According to the degree of importance to the combined analgesic effect, Ace > Caf > Bul; Ace showed a significant dose-response relationship, whereas in Caf and Bul, this relationship was not apparent." | 1.31 | Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital. ( Gui, CQ; Sun, RY; Wang, XW; Zheng, QS, 2001) |
| "Pretreatment with naloxone abolished this antinociceptive activity both in the hot-plate test and in the first phase of the formalin test without affecting the serum concentration of paracetamol." | 1.30 | Naloxone-reversible antinociception by paracetamol in the rat. ( Ottani, A; Pini, LA; Sandrini, M; Vitale, G, 1997) |
| " Tablets "Paravit" have mark, which allows exact dosing for children of different age." | 1.30 | [The physiological properties of the action of a new analgesic and antipyretic preparation]. ( Chernykh, VP; Shapovalova, VO, 1997) |
| "There are no adequate pharmacodynamic data relating concentrations of acetaminophen in serum to analgesia." | 1.30 | Perioperative pharmacodynamics of acetaminophen analgesia in children. ( Anderson, BJ; Holford, NH; Kanagasundaram, S; Mahadevan, M; Woollard, GA, 1999) |
| "Diclofenac was the NSAID of choice for 69." | 1.30 | Analgesia in soft-tissue injury: current practice in Auckland is not supported by the available evidence. ( Jones, PG, 1999) |
| "Twenty patients with end-stage head and neck cancer, unresponsive to either acetaminophen with codeine or oxycodone hydrochloride, were placed on a four-drug analgesic regimen consisting of methadone hydrochloride, Trilisate or acetaminophen, a tricyclic antidepressant, and, in most cases, hydroxyzine." | 1.29 | A four-drug pain regimen for head and neck cancers. ( Carrol, EN; Fine, E; Ruff, RL; Stepnick, D, 1994) |
| "Osteoarthritis is a chronic disease that has exacerbations and remissions." | 1.29 | Osteoarthritis treatment update. Minimizing pain while limiting patient risk. ( Schnitzer, TJ, 1993) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| "Continuous Reaction Time (CRT) was measured in cancer patients receiving peripherally acting analgesics either alone (n = 16) or in combination with opioids (n = 16)." | 1.28 | Reaction time in cancer patients receiving peripherally acting analgesics alone or in combination with opioids. ( Banning, A; Kaiser, F; Sjøgren, P, 1992) |
| " Incidence of side effects and toxicity may be reduced by choice of drug and modification of dosing regimen." | 1.28 | Nonnarcotic analgesics and tricyclic antidepressants for the treatment of chronic nonmalignant pain. ( Richlin, DM, 1991) |
| "Acetaminophen is an effective analgesic and antipyretic agent with few adverse effects when used in recommended dosages." | 1.27 | Acetaminophen: a practical pharmacologic overview. ( Cornett, JW; Jackson, CH; MacDonald, NC, 1984) |
| " FS 205-397 will offer potent analgesic and antipyretic therapy in man based on an innovative biochemical principle which eliminates the undesirable toxic effects associated with most other non-narcotic analgesics." | 1.27 | FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice. ( Achini, R; Foote, RW; Römer, D, 1988) |
| "On the other hand, certain tumors require local blockade as in cases with pancreatic or perianal tumors." | 1.27 | [Therapy of pain caused by gastrointestinal tumors]. ( Zenz, M, 1987) |
| " Patients were maintained on their normal treatment and dosage schedules (600 mg every 3 to 8 h) for the study." | 1.27 | The effect of acetaminophen administration on its disposition and body stores of sulphate. ( Danilkewich, A; Hendrix-Treacy, S; Hindmarsh, KW; Wallace, SM; Wyant, GM, 1986) |
| "Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially." | 1.26 | Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. ( Lovejoy, FH; Mitchell, AA; Shapiro, S; Slone, D, 1982) |
| " A significant reduction in the LD50 was seen in the alcohol-pretreated mice, and correlations were noted between histological findings in the liver and the LD50 data." | 1.26 | Potentiation of acetaminophen hepatotoxicity by alcohol. ( Holtzman, JL; Kromhout, JP; McClain, CJ; Peterson, FJ, 1980) |
| "Phenacetin was active in the trypsin and kaolin assays with oral ED50's of 114 +/- 36." | 1.26 | Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents. ( Selph, JL; Truax, JF; Vinegar, R, 1976) |
| " In therapeutic dosage of 6 to 12 mg." | 1.23 | The sublingual administration of curare. ( MAYER, H; NEFF, WB, 1953) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 185 (16.06) | 18.7374 |
| 1990's | 114 (9.90) | 18.2507 |
| 2000's | 334 (28.99) | 29.6817 |
| 2010's | 383 (33.25) | 24.3611 |
| 2020's | 136 (11.81) | 2.80 |
| Authors | Studies |
|---|---|
| Shinoda, S | 1 |
| Aoyama, T | 1 |
| Aoyama, Y | 1 |
| Tomioka, S | 1 |
| Matsumoto, Y | 1 |
| Ohe, Y | 1 |
| Friesen, RW | 1 |
| Mancini, JA | 1 |
| de Campos Buzzi, F | 1 |
| Franzoi, CL | 1 |
| Antonini, G | 1 |
| Fracasso, M | 2 |
| Cechinel Filho, V | 1 |
| Yunes, RA | 3 |
| Niero, R | 2 |
| Tripathi, P | 1 |
| Tripathi, AC | 1 |
| Chawla, V | 1 |
| Saraf, SK | 1 |
| Å Nilsson, JL | 1 |
| Mallet, C | 4 |
| Shionoya, K | 1 |
| Blomgren, A | 1 |
| Sundin, AP | 1 |
| Grundemar, L | 1 |
| Boudieu, L | 1 |
| Blomqvist, A | 1 |
| Eschalier, A | 12 |
| Nilsson, UJ | 1 |
| Zygmunt, PM | 1 |
| Murphy, V | 1 |
| Koea, J | 1 |
| Srinivasa, S | 1 |
| Schuler, M | 1 |
| Rubin, JB | 1 |
| Lai, JC | 1 |
| Shui, AM | 1 |
| Hohmann, SF | 1 |
| Auerbach, A | 1 |
| Gustafsson, M | 1 |
| Lövheim, H | 1 |
| Sjölander, M | 1 |
| Hickey, T | 1 |
| Abelleira, A | 1 |
| Acampora, G | 1 |
| Becker, WC | 1 |
| Falker, CG | 1 |
| Nazario, M | 1 |
| Weimer, MB | 1 |
| Patterson, TG | 1 |
| Beckenkamp, P | 1 |
| Ferreira, M | 1 |
| Turner, J | 1 |
| Gnjidic, D | 1 |
| Chen, Y | 1 |
| Mesa Castrillion, CI | 1 |
| Ferreira, P | 1 |
| Rogers, TS | 1 |
| Chandler, M | 1 |
| Hall, A | 1 |
| Miranda, HF | 6 |
| Noriega, V | 3 |
| Sierralta, F | 3 |
| Sotomayor-Zárate, R | 1 |
| Prieto, JC | 6 |
| Martínez-Martínez, MDC | 1 |
| Parra-Flores, LI | 1 |
| Baeza-Flores, GDC | 1 |
| Torres-López, JE | 1 |
| El-Sheikh, A | 1 |
| Khired, Z | 1 |
| Owayda, AM | 1 |
| Hajeer, MY | 1 |
| Murad, RMT | 1 |
| Al-Sabbagh, R | 1 |
| Friedlander, EB | 1 |
| Raidoo, S | 1 |
| Soon, R | 1 |
| Salcedo, J | 1 |
| Davis, J | 1 |
| Tschann, M | 1 |
| Fontanilla, T | 1 |
| Horiuchi, W | 1 |
| Kaneshiro, B | 1 |
| Kara, A | 1 |
| Büyükcam, A | 1 |
| Sütçü, M | 1 |
| Sali, E | 1 |
| Bozdemir, ŞE | 1 |
| Kara, M | 1 |
| İlarslan, EÇ | 1 |
| Kaya, C | 1 |
| Karakaşlılar, S | 1 |
| Sönmez, G | 1 |
| Kara, SS | 1 |
| Bedir, T | 1 |
| Albayrak, E | 2 |
| Kara, TT | 1 |
| Çelebi, S | 1 |
| Öz, FN | 1 |
| Karbuz, A | 1 |
| Somer, A | 1 |
| Alabaz, D | 1 |
| Tezer, H | 1 |
| Özdemir, H | 1 |
| Çiftçi, E | 1 |
| Morse, JD | 1 |
| Stanescu, I | 1 |
| Atkinson, HC | 1 |
| Anderson, BJ | 6 |
| Murthykumar, K | 1 |
| Rajasekar, A | 1 |
| Kaarthikeyan, G | 1 |
| Constantin, KL | 1 |
| Lupo-Flewelling, K | 1 |
| Moline, RL | 1 |
| McMurtry, CM | 1 |
| Guo, J | 1 |
| Wang, T | 1 |
| Zheng, X | 1 |
| Long, Y | 1 |
| Wang, X | 2 |
| Zhang, Q | 1 |
| Liu, J | 2 |
| Zhang, G | 1 |
| Zha, J | 1 |
| Hou, Z | 1 |
| Zhang, Y | 3 |
| Lee, N | 1 |
| Mårtensson, LB | 1 |
| Ezzati, A | 1 |
| Fanning, KM | 1 |
| Buse, DC | 1 |
| Pavlovic, JM | 1 |
| Armand, CE | 1 |
| Reed, ML | 1 |
| Martin, VT | 1 |
| Lipton, RB | 1 |
| Reynolds-Wright, JJ | 1 |
| Woldetsadik, MA | 1 |
| Morroni, C | 1 |
| Cameron, S | 1 |
| Bozorgmanesh, M | 1 |
| Valibeik, S | 1 |
| Shokrpour, M | 1 |
| Maktabi, M | 1 |
| Kamali, A | 1 |
| Thirunavukarasu, AJ | 1 |
| Hassan, R | 1 |
| Savant, SV | 1 |
| Hamilton, DL | 1 |
| Smith, MD | 1 |
| Rowan, E | 1 |
| Spaight, R | 1 |
| Siriwardena, AN | 1 |
| Ruffin, TB | 1 |
| Salinero, E | 1 |
| Papa, L | 1 |
| Cramm, K | 1 |
| Florez, C | 1 |
| Chen, JG | 1 |
| Ramirez, J | 1 |
| Benhenneda, R | 1 |
| Letissier, H | 1 |
| Dubrana, F | 1 |
| Di Francia, R | 1 |
| Meunier, V | 1 |
| Mares, O | 1 |
| Gricourt, Y | 1 |
| Simon, N | 1 |
| Kouyoumdjian, P | 1 |
| Cuvillon, P | 1 |
| Spence, JD | 1 |
| Grosser, T | 1 |
| FitzGerald, GA | 1 |
| Zhang, J | 1 |
| Zhai, X | 1 |
| Wang, L | 1 |
| Tong, H | 1 |
| Xian, T | 1 |
| Shao, L | 1 |
| Paschoal, NOS | 1 |
| Natour, J | 1 |
| Machado, FS | 1 |
| Oliveira, HAV | 1 |
| Fernandes, ADRC | 1 |
| Furtado, RNV | 1 |
| Gong, JJ | 1 |
| Chen, CC | 1 |
| Lebaron, J | 1 |
| Chary, MA | 1 |
| Brant, A | 1 |
| Lewicki, P | 1 |
| Johnson, JP | 1 |
| Weinstein, IC | 1 |
| Bowman, A | 1 |
| Sze, C | 1 |
| Shoag, JE | 1 |
| Fallon, M | 1 |
| Dierberger, K | 1 |
| Leng, M | 1 |
| Hall, PS | 1 |
| Allende, S | 1 |
| Sabar, R | 1 |
| Verastegui, E | 1 |
| Gordon, D | 1 |
| Grant, L | 1 |
| Lee, R | 1 |
| McWillams, K | 1 |
| Murray, GD | 1 |
| Norris, L | 1 |
| Reid, C | 1 |
| Sande, TA | 1 |
| Caraceni, A | 2 |
| Kaasa, S | 1 |
| Laird, BJA | 1 |
| Wang, Y | 2 |
| Fan, M | 1 |
| Wang, H | 1 |
| You, Y | 1 |
| Wei, C | 1 |
| Liu, M | 1 |
| Luo, A | 1 |
| Xu, X | 1 |
| Duan, X | 1 |
| Mabaso, LMN | 1 |
| Bhettay, A | 1 |
| Bandini, R | 1 |
| Demopoulos, D | 1 |
| Turgut, K | 1 |
| Yavuz, E | 1 |
| Gülaçtı, U | 1 |
| Aydın, İ | 1 |
| Sönmez, C | 1 |
| Aktaş, N | 1 |
| Arslan, E | 1 |
| Altarifi, AA | 1 |
| Younis, BA | 1 |
| Nuseir, KQ | 1 |
| Al-Mousa, AA | 1 |
| Qaoud, AK | 1 |
| Alsalem, MI | 1 |
| Neubert, JK | 1 |
| Wadström, MG | 1 |
| Hailer, YD | 1 |
| Li, W | 3 |
| Zhang, X | 3 |
| Han, J | 3 |
| Falise, AM | 2 |
| Sharma, V | 2 |
| Hoeflich, CC | 2 |
| Lopez-Quintero, C | 2 |
| Striley, CW | 2 |
| Helvik, AS | 3 |
| Bergh, S | 3 |
| Kabukcuoğlu, K | 1 |
| Šaltytė Benth, J | 3 |
| Lichtwarck, B | 1 |
| Husebø, B | 2 |
| Tevik, K | 3 |
| Weng, Q | 1 |
| Goh, SL | 1 |
| Wu, J | 2 |
| Persson, MSM | 2 |
| Wei, J | 2 |
| Sarmanova, A | 1 |
| Li, X | 1 |
| Hall, M | 1 |
| Doherty, M | 4 |
| Jiang, T | 1 |
| Zeng, C | 2 |
| Lei, G | 2 |
| Zhang, W | 3 |
| Ben Othman, A | 1 |
| Ben Ali, R | 1 |
| Ben Akacha, A | 1 |
| El May, MV | 1 |
| Burghle, A | 1 |
| Pottegård, A | 1 |
| Rasmussen, M | 1 |
| Bruun, B | 1 |
| Roost Hosbjerg, J | 1 |
| Lundby, C | 1 |
| Sun, CK | 1 |
| Tsai, TH | 1 |
| Desomer, L | 1 |
| Tate, DJ | 1 |
| Pillay, L | 1 |
| Awadie, H | 1 |
| Sidhu, M | 1 |
| Ahlenstiel, G | 1 |
| Bourke, MJ | 1 |
| Resnick, B | 1 |
| Boltz, M | 1 |
| Galik, E | 1 |
| Ellis, J | 1 |
| Kuzmik, A | 1 |
| Drazich, B | 1 |
| McPherson, R | 1 |
| Kim, E | 1 |
| Mohanty, CR | 1 |
| Gupta, A | 1 |
| Gupta, N | 1 |
| Radhakrishnan, RV | 1 |
| Dersch-Mills, D | 1 |
| Howlett, A | 1 |
| Lind, J | 1 |
| Marchuk, A | 1 |
| Mohammad, K | 1 |
| Zempsky, W | 1 |
| Bell, J | 1 |
| Mossali, VM | 1 |
| Kachroo, P | 1 |
| Siddiqui, K | 1 |
| Ricci, C | 1 |
| Albanese, CM | 1 |
| Pablo, LA | 1 |
| Li, J | 3 |
| Fatima, M | 1 |
| Barrett, K | 1 |
| Levis, B | 1 |
| Brown, HK | 1 |
| Jelsone-Swain, L | 1 |
| McCommon, SA | 1 |
| Turk, B | 1 |
| Roach, A | 1 |
| Shykhveisi, F | 1 |
| Jafarian Amiri, R | 1 |
| Zabihi, A | 1 |
| Haghshenas Mojaveri, M | 1 |
| Arzani, A | 1 |
| Chehrazi, M | 1 |
| Chari, ZV | 1 |
| Zullo, F | 1 |
| Di Mascio, D | 1 |
| Berghella, V | 1 |
| Dowd, LA | 1 |
| Cross, AJ | 1 |
| Liau, SJ | 1 |
| Jadczak, AD | 1 |
| Visvanathan, R | 2 |
| Veal, FC | 2 |
| Bell, JS | 2 |
| Cetira-Filho, EL | 1 |
| Martins-Filho, PR | 1 |
| de Barros Silva, PG | 1 |
| da Hora Sales, PH | 1 |
| Vieira, AF | 1 |
| Sindeaux, LME | 1 |
| Dos Anjos, MO | 1 |
| Leão, JC | 1 |
| Costa, FWG | 1 |
| Sato, S | 1 |
| Tomitori, H | 1 |
| Okawa, A | 1 |
| Akano, K | 1 |
| Brandelli, YN | 1 |
| Chambers, CT | 2 |
| Mackinnon, SP | 1 |
| Parker, JA | 2 |
| Huber, AM | 1 |
| Stinson, JN | 2 |
| Wildeboer, EM | 1 |
| Wilson, JP | 1 |
| Piccolo, O | 1 |
| Haslund-Krog, S | 1 |
| Barry, JM | 1 |
| Birnbaum, AK | 1 |
| Dalhoff, K | 1 |
| Brink Henriksen, T | 1 |
| Sherwin, CMT | 1 |
| Avachat, C | 1 |
| Poulsen, S | 1 |
| Christensen, U | 1 |
| Remmel, RP | 1 |
| Wilkins, D | 2 |
| van den Anker, JN | 9 |
| Holst, H | 1 |
| Goyal, B | 1 |
| Bishnoi, S | 1 |
| Parveen, S | 1 |
| Patel, D | 1 |
| Yasmeen, - | 1 |
| Tarekar, A | 1 |
| Stróżyk, A | 1 |
| Paraskevas, T | 1 |
| Romantsik, O | 1 |
| Calevo, MG | 1 |
| Banzi, R | 1 |
| Ley, D | 1 |
| Bruschettini, M | 1 |
| Stamenkovic, D | 1 |
| Baumbach, P | 1 |
| Radovanovic, D | 1 |
| Novovic, M | 1 |
| Ladjevic, N | 1 |
| Dubljanin Raspopovic, E | 1 |
| Palibrk, I | 1 |
| Unic-Stojanovic, D | 1 |
| Jukic, A | 1 |
| Jankovic, R | 1 |
| Bojic, S | 1 |
| Gacic, J | 1 |
| Stamer, UM | 1 |
| Meissner, W | 1 |
| Zaslansky, R | 1 |
| de Sévaux, JLH | 1 |
| Damoiseaux, RA | 2 |
| van de Pol, AC | 2 |
| Lutje, V | 1 |
| Hay, AD | 2 |
| Little, P | 2 |
| Schilder, AG | 2 |
| Venekamp, RP | 2 |
| Shah, PS | 4 |
| Torgalkar, R | 1 |
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| Shabbir, M | 1 |
| Bugayong, ML | 1 |
| DeVita, MA | 1 |
| Zambelli, VO | 1 |
| Gross, ER | 1 |
| Harris, E | 1 |
| Huang, Y | 1 |
| Meng, L | 1 |
| Zhou, R | 1 |
| Luo, F | 1 |
| Borza, T | 1 |
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| Mercante, A | 1 |
| Cattaneo, D | 1 |
| Alberti, I | 1 |
| Agostoni, C | 1 |
| Benini, F | 1 |
| Carabot, F | 1 |
| Donat-Vargas, C | 1 |
| Santoma-Vilaclara, J | 1 |
| Ortega, MA | 1 |
| García-Montero, C | 1 |
| Fraile-Martínez, O | 1 |
| Zaragoza, C | 1 |
| Monserrat, J | 1 |
| Alvarez-Mon, M | 1 |
| Alvarez-Mon, MA | 1 |
| Mahmoud, AM | 1 |
| Allam, AR | 1 |
| Strickmann, B | 1 |
| Deicke, M | 1 |
| Hoyer, A | 1 |
| Kobiella, A | 1 |
| Jansen, G | 1 |
| Sodeifian, G | 1 |
| Garlapati, C | 1 |
| Arbab Nooshabadi, M | 1 |
| Razmimanesh, F | 1 |
| Roshanghias, A | 1 |
| Connolly, KP | 1 |
| Kleinman, RS | 1 |
| Stevenson, KL | 1 |
| Neuman, MD | 1 |
| Mehta, SN | 1 |
| Poblete, P | 1 |
| Aranda, N | 1 |
| Varrassi, G | 1 |
| Alon, E | 1 |
| Bagnasco, M | 1 |
| Lanata, L | 1 |
| Mayoral-Rojals, V | 1 |
| Paladini, A | 1 |
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| Perrot, S | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylactic Pregabalin to Decrease Pain During Medical Abortion: a Randomized Controlled Trial[NCT02782169] | Phase 4 | 110 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| PAIN CONTROL IN FIRST TRIMESTER MEDICAL ABORTION: A Randomized Trial[NCT01457521] | Phase 4 | 250 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| The Effect of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion: A Double-blind Randomized Placebo Controlled Study[NCT00997074] | Phase 3 | 61 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Paravertebral Block Versus Simultaneous Ketamine and Lidocaine Infusions for Pain Management in Rib Fracture Patients[NCT04413799] | Early Phase 1 | 170 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | ||
| Paracetamol Route in Palliative Care Patients : Intravenous Versus Subcutaneous Route Pharmacokinetics, Study Protocol for a Randomized Equivalence Pilot Trial[NCT03944044] | 20 participants (Anticipated) | Interventional | 2019-07-15 | Recruiting | |||
| A Randomized, Double-Blind, 7-Day Study of the Efficacy and Safety of Rofecoxib Versus Placebo and Diclofenac in Patients With Acute Painful Rotator Cuff Syndrome[NCT00140933] | Phase 3 | 274 participants | Interventional | 2003-04-30 | Terminated | ||
| Efficacy and Security of Combined Analgesia (Opioid and Anti-inflammatory Agent) to Control Pain in Children Seen in the Emergency Department for a Trauma of a Limb[NCT01189773] | Phase 4 | 200 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| An Open Label Randomized Multicenter Comparative Study On Celecoxib Efficacy And Safety Versus Non-Selective NSAID In Acute Pain Due To Ankle Sprain[NCT00446797] | Phase 4 | 278 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Ibuprofen Versus Acetaminophen vs Their Combination in the Relief of Musculoskeletal Pain in the Emergency Setting[NCT01827475] | Phase 2 | 90 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| The Efficacy and Safety of Administration of the COX-2 Selective NSAID, Etoricoxib (120mg od. for 7 Days) Compared to Diclofenac (50 mg Tds. for 7 Days) and Placebo as Adjunct Treatment in the First 7 Days of Treatment of Acute Grade II Lateral Ankle Liga[NCT00954785] | Phase 4 | 0 participants (Actual) | Interventional | 2009-11-30 | Withdrawn (stopped due to The study was terminated by Merck USA. The company did not supply drugs for the study.) | ||
| An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995] | Phase 1 | 30 participants (Anticipated) | Interventional | 2023-09-13 | Recruiting | ||
| Pharmacogenomics of APAP Induced DILI in Chinese Population.[NCT04964310] | 339 participants (Anticipated) | Observational | 2020-08-31 | Recruiting | |||
| Battlefield Auricular Acupuncture for Control of Post-partum Pain[NCT02526186] | 90 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| CRAMPS Trial: Controlled Randomized Trial Assessing Maternal Post-partum Pain With Suppositories[NCT01271855] | Phase 4 | 100 participants (Actual) | Interventional | 2009-07-22 | Completed | ||
| Comparison Between 2 Pain Analgesic Protocols Following Vaginal Delivery[NCT04087317] | 220 participants (Anticipated) | Interventional | 2019-09-01 | Not yet recruiting | |||
| Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery: A Prospective Double Blind Randomized Control Trial[NCT04017442] | Phase 4 | 140 participants (Actual) | Interventional | 2019-10-19 | Completed | ||
| Post-partum Non-pharmacologic Pain Management[NCT03903172] | 130 participants (Anticipated) | Interventional | 2019-06-01 | Enrolling by invitation | |||
| Effect of Foot Massage on Postpartum Comfort and Pain Level of the Mothers Who Had Vaginal Birth: A Randomised Controlled Trial[NCT04037202] | 66 participants (Actual) | Interventional | 2017-07-03 | Completed | |||
| EFFICACY OF GINGER EXTRACT ON PAIN RELIEF FOR FIRST NORMAL POSTPARTUM WOMEN[NCT03617900] | Phase 1/Phase 2 | 99 participants (Actual) | Interventional | 2018-08-29 | Completed | ||
| Dental Support Device During Breastfeeding as a Mean for Pain Control[NCT02399774] | Phase 3 | 1,500 participants (Anticipated) | Interventional | 2015-05-31 | Not yet recruiting | ||
| Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment[NCT05986513] | 66 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Cost-effectiveness Analysis of Oral Paracetamol and Ibuprofen for Treating Pain After Soft Tissue Limb Injuries: Double-blind, Randomised Controlled Trial[NCT00528658] | Phase 2 | 782 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Effective Strategy to Cope the Pain and Discomfort Among Women Undergoing Mammography[NCT04381104] | 632 participants (Anticipated) | Interventional | 2019-11-21 | Recruiting | |||
| Tolerance and Efficiency of Paracetamol bu Subcutaneous Releasing in Patients Hospitalized Into Palliative Care[NCT02884609] | 160 participants (Actual) | Observational | 2014-08-31 | Completed | |||
| Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery[NCT02573922] | Phase 4 | 180 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Full-Factorial, Parallel-Group Study Evaluating Safety and Efficacy of Naltrexone-Acetaminophen Combination in Acute Migraine Treatment in Adults, With Exploratory Focus on Co-Occurring[NCT05685225] | Phase 2 | 300 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| Clinical Evaluation of the Effectiveness of Different Methods in Reducing Pain During Debonding of Orthodontic Fixed Appliance: a Randomized Clinical Trial[NCT05904587] | 128 participants (Anticipated) | Interventional | 2023-03-19 | Recruiting | |||
| Haemodynamic Effects of Paracetamol (Acetaminophen) as Extended Intravenous Infusion Versus Intravenous Bolus in Septic Shock Patients[NCT06076980] | Phase 4 | 61 participants (Actual) | Interventional | 2020-11-01 | Completed | ||
| Non - Opioid Treatments (Single Administration) for Pain During the Early Postpartum Period After Vaginal Delivery[NCT04653506] | 1,000 participants (Anticipated) | Interventional | 2020-11-28 | Recruiting | |||
| A Single Blinded, Open-labelled, Randomized Control Trial Comparing Acetaminophen Rectal Suppository With Diclofenac Rectal Suppository as Analgesia for Perineal Injury Following Childbirth[NCT03041779] | Phase 2 | 909 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| The Impact of Pain on Behavioural Disturbances in Patients With Moderate and Severe Dementia. A Cluster Randomized Trial[NCT01021696] | Phase 2/Phase 3 | 352 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041] | Phase 3 | 248 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Air as a Placebo: Increasing the Respiratory Performance of People With COPD Through Simple Expectations of Improvement. An Experimental, Randomised, Two-arm, Counterbalanced Study With Three Data Collection Sessions.[NCT05218564] | 102 participants (Anticipated) | Interventional | 2020-02-19 | Recruiting | |||
| Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial[NCT05891132] | 60 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Ultrasound Guided Central Line Insertion in Neonates: Pain Score Results From a Prospective Study[NCT03647293] | 61 participants (Actual) | Interventional | 2016-11-30 | Completed | |||
| [NCT01947205] | 111 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| Percutaneous Pin Removal in the Outpatient Clinic - do Children Require Analgesia? A Randomized Controlled Trial[NCT01944085] | 240 participants (Actual) | Interventional | 2008-10-31 | Completed | |||
| A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Acetaminophen Extended Release (3900 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee.[NCT00240799] | Phase 3 | 542 participants (Actual) | Interventional | Completed | |||
| Pilot, Open Non-controled Trial to Assess the Feasibility of Implementing Objective Parameters as Primary Endpoints in a Clinical Trial With Patients Affected by Knee Osteoarthritis[NCT03421054] | 8 participants (Actual) | Interventional | 2018-03-19 | Completed | |||
| Double Blind, Placebo Controlled Trial to Evaluate the Effects of a Nutraceutical Containing High-Molecular-Weight Hyaluronic Acid (HA) and Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) in Patients Affected by Knee Osteoarthritis[NCT03612986] | 72 participants (Actual) | Interventional | 2018-08-22 | Completed | |||
| Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial[NCT00652093] | Phase 4 | 24 participants (Actual) | Interventional | 2008-03-31 | Terminated (stopped due to Removal of Darvocet from US market) | ||
| Use of Intravenous Acetaminophen in Adolescents and Pediatrics Undergoing Spinal Fusion Surgery: Randomized Controlled Trial[NCT04959591] | Phase 3 | 99 participants (Actual) | Interventional | 2021-06-01 | Completed | ||
| Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI[NCT01562704] | Phase 1 | 21 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Therapeutic Effect of Inexpensive, Flexible and Non-heeled Footwear on the Clinical, Functional and Gait Biomechanics in Elderly Women With Knee Osteoarthritis: a Randomized Clinical Trial[NCT01342458] | Phase 1 | 56 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Extremely Low Gestational Age Infants' Paracetamol Study: a Randomized Trial[NCT03641209] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2018-09-03 | Active, not recruiting | ||
| Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus of Preterm Infants - Randomised, Placebo-controlled Multicentre Trial[NCT03648437] | Phase 1 | 60 participants (Anticipated) | Interventional | 2018-09-03 | Recruiting | ||
| Comparison of the Effects of Ibuprofen and Low-Level Laser Therapy on Orthodontic Pain By Means of Interleukin 1-Beta and Substance P Levels in the Gingival Crevicular Fluid[NCT04070001] | 60 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| Battlefield Acupuncture to Treat Pain in Hidradenitis Suppurativa[NCT04218422] | 32 participants (Anticipated) | Interventional | 2020-01-22 | Recruiting | |||
| A Phase 3, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Fixed-Dose, Parallel-Group, Efficacy, and Safety Study of Meloxicam SoluMatrix™ Capsules in Patients With Pain Due to Osteoarthritis of the Knee or Hip[NCT01787188] | Phase 3 | 403 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| The Effect of Chronic Pain Relief Over Knee Joint Area by Gua Sha Therapy[NCT03821194] | 40 participants (Anticipated) | Interventional | 2019-01-25 | Recruiting | |||
| [NCT01993589] | 144 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| A Randomized, Comparison Study of L.M.X.4 Cream Versus J-Tip Needle-Free Injection System With Lidocaine in Children Undergoing In-Office Percutaneous Achilles Tenotomy for Clubfoot[NCT04766684] | Phase 4 | 94 participants (Anticipated) | Interventional | 2021-06-01 | Recruiting | ||
| Dexmedetomidine for LISA Procedure in Preterm Infants: a Pilot Study[NCT04820101] | 40 participants (Anticipated) | Interventional | 2021-05-15 | Not yet recruiting | |||
| Maternal Involvement in Pain Management in NICU: a Randomized Controlled Trial[NCT04883944] | 50 participants (Actual) | Interventional | 2021-05-17 | Completed | |||
| 40% Orally Administered Dextrose Gel is More Effective Than 25% Dextrose But Not Sufficiently Reliefs Acute Pain in Term Neonates: A Randomized Controlled Trial[NCT02984098] | Phase 4 | 200 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electromyography in Pediatric Population-A Randomized Controlled Trial[NCT04337814] | 113 participants (Actual) | Interventional | 2019-12-30 | Completed | |||
| Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics[NCT02417337] | Phase 2 | 170 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Effect of Preoperative, Single-dose Diclofenac Potassium on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double Blind Randomized Controlled Trial[NCT03341260] | Phase 2/Phase 3 | 70 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| The Copenhagen Analgesic Study[NCT04369222] | 600 participants (Anticipated) | Observational | 2020-03-01 | Recruiting | |||
| Childrens' Experiences of Pain in Conjunction With Tooth Extraction - a Grounded Theory[NCT04064853] | 12 participants (Actual) | Observational | 2019-04-05 | Completed | |||
| Comparison of Pre-emptive Ibuprofen, Acetaminophen, and Placebo Administration in Reducing Local Anesthesia Injection Pain and Post-operative Pain in Primary Tooth Extraction. A Clinical Study[NCT03786029] | Phase 2/Phase 3 | 66 participants (Actual) | Interventional | 2019-04-01 | Completed | ||
| Effect of Preoperative Administration of Ibuprofen in Children Undergoing Extraction for Reducing Postoperative Pain: A Double-blind Randomized Controlled Clinical Trial[NCT04476069] | Phase 3 | 56 participants (Actual) | Interventional | 2019-01-10 | Completed | ||
| Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319] | Phase 3 | 300 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Use of Atorvastatin (Lipitor) to Prevent Bone Pain Following Infusion of Pamidronate or Zoledronic Acid[NCT00120133] | 12 participants (Actual) | Interventional | 2004-12-31 | Completed | |||
| Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678] | Phase 4 | 0 participants (Actual) | Interventional | 2014-02-28 | Withdrawn (stopped due to Investigator left institution) | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Randomized Double-blind Controlled Study to Assess the Efficacy of Intravenous Acetaminophen Associated With Strong Opioids in the Management of Acute Pain in Adult Cancer Patients[NCT04779567] | Phase 4 | 112 participants (Actual) | Interventional | 2019-06-10 | Completed | ||
| Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement: a Randomized Controlled Trial[NCT03568721] | Phase 4 | 81 participants (Actual) | Interventional | 2015-01-25 | Completed | ||
| The Effect of the Chewing Gum in Alleviating Orthodontic Pain After Separator and Initial Arch Wire Placement: A Randomized Clinical Trial[NCT04836234] | 108 participants (Anticipated) | Interventional | 2019-03-06 | Recruiting | |||
| Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain of Initial Orthodontic Wire Insertion: a Randomized Controlled Trial[NCT04059172] | Early Phase 1 | 375 participants (Anticipated) | Interventional | 2019-12-10 | Recruiting | ||
| Double-blind, Randomized, Placebo-controlled Study on the Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing Intrauterine System[NCT02799641] | 61 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| Comparison of Analgesic Efficacy of Dexketoprofen and Ibuprofen in Long Bone Fractures: Randomised Controlled Double-blind Study[NCT06060236] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136] | Phase 4 | 84 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Ibuprofen vs. Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?[NCT01605240] | 50 participants (Anticipated) | Interventional | 2012-07-31 | Recruiting | |||
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [NCT01773044] | Phase 4 | 300 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| "Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623] | 300 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Randomized Clinical Trial of Buzzy Versus Vapocoolant in Pain Relief During Phlebotomy and IV Catheterization in the Pediatric ED[NCT06182631] | Phase 3 | 176 participants (Actual) | Interventional | 2019-07-15 | Completed | ||
| Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis[NCT00666523] | 81 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| A Double-Blind, Placebo-Controlled, 3-Period Crossover Study to Evaluate the Analgesic Effects of Naproxen and Ultracet in a Walking Model of Osteoarthritis Knee Pain[NCT00772967] | Phase 1 | 22 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| A Randomized, Placebo-Controlled Single-Dose 3-Period Crossover Study to Assess the Tolerability and Efficacy of Ibuprofen 800 mg in a Walking Model of Osteoarthritis Pain[NCT00565084] | Phase 1 | 33 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Impact of Intrathecal Dexamethasone Administration for Elderly Patients With Proximal Femoral Fracture[NCT03856502] | 60 participants (Actual) | Interventional | 2012-11-11 | Completed | |||
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699] | Phase 4 | 41 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| A Clinical Trial to Assess a Single Dose of Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine[NCT03061734] | Phase 2 | 92 participants (Actual) | Interventional | 2017-02-18 | Completed | ||
| Acetaminophen and Social Pain in Borderline Personality Disorder[NCT02108990] | Phase 2 | 9 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Confirmatory Efficacy and Safety Study of the Fixed-dose Combination of Etoricoxib / Tramadol Versus Acetaminophen / Tramadol for the Management of Acute Low Back Pain.[NCT04968158] | Phase 3 | 124 participants (Actual) | Interventional | 2021-11-29 | Completed | ||
| The Effect of Lokal Cold Application in Nitroglycerin-Induced Headache[NCT04707586] | 70 participants (Anticipated) | Interventional | 2020-12-15 | Recruiting | |||
| Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040] | 121 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries[NCT04199572] | Phase 4 | 162 participants (Actual) | Interventional | 2022-10-16 | Completed | ||
| A Double Blind, Multi-arm Randomized Control Trial, for Efficacy of Intramuscular Diclofenac Versus Intravenous Morphine Versus Intravenous Paracetamol, in Renal Colic Emergency Department Pain Management[NCT02187614] | Phase 4 | 1,645 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| [NCT01833728] | 16 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial.[NCT02056223] | Phase 2/Phase 3 | 120 participants (Anticipated) | Interventional | 2017-01-09 | Suspended (stopped due to We enrolled only 53 patients) | ||
| Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?[NCT00488540] | Phase 4 | 280 participants (Anticipated) | Interventional | 2007-06-30 | Completed | ||
| Disposition of Intravenous Paracetamol in Young Women, Including During Pregnancy, in Postpartum or When on Oral Contraceptives[NCT02590900] | 69 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Preoperative Cesarean Section Intravenous Acetaminophen and Postoperative Pain Control: A Blinded Randomized Placebo-Controlled Trial[NCT02694653] | Phase 1 | 200 participants (Anticipated) | Interventional | 2014-10-31 | Enrolling by invitation | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| A Randomized, Double-Blinded, Placebo Controlled Trial Using Single Dose Dexmedetomidine In The Treatment Of Pain In Patients Undergoing Cleft Palate Repair[NCT02915042] | Phase 4 | 0 participants (Actual) | Interventional | 2017-12-31 | Withdrawn (stopped due to Recruitment concerns) | ||
| Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716] | 600 participants (Anticipated) | Interventional | 2018-07-06 | Enrolling by invitation | |||
| Predicting Perioperative Opioid Adverse Effects and Personalizing Analgesia in Children: A Multicenter Pharmacogenetic Study[NCT01495611] | 1,000 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| A Randomized, Crossover, Pilot Trial of the Feasibility and Safety of Acupoint Injection of Vitamin K for Treatment of Primary Dysmenorrhea[NCT00995917] | 18 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| PINPOINT: Gaming Technology to Engage Adolescent Sickle Cell Patients in Precision Pain Management[NCT03291613] | 13 participants (Actual) | Interventional | 2017-01-15 | Completed | |||
| Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029] | 220 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313] | 152 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | |||
| A Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled Study to Evaluate the Efficacy of Rofecoxib and a Dosing Regimen of Oxycodone With Acetaminophen Over 24 Hours in Patients With Postoperative Dental Pain[NCT00092313] | Phase 3 | 271 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| Efficacy Evaluation of Intra-articular Hyaluronic Acid (Sinovial®) vs Synvisc® in the Treatment of Symptomatic Knee Osteoarthritis. A Double-blind, Controlled, Randomised, Parallel-group Non-inferiority Study[NCT00556608] | Phase 4 | 381 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| A Trial of Prednisone and Acetaminophen Versus Acetaminophen Alone in Minimizing Flu-like Symptoms From Pegylated Interferon Beta-1a[NCT03424733] | Phase 4 | 50 participants (Anticipated) | Interventional | 2017-09-25 | Recruiting | ||
| Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study[NCT00525967] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2006-02-28 | Recruiting | ||
| The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded C[NCT04804761] | 20 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting | |||
| Effectiveness of a Combined Acetaminophen and Ibuprofen Regimen for Management of Post-Tonsillectomy Pain in Pediatric Patients[NCT04551196] | Phase 3 | 47 participants (Actual) | Interventional | 2020-09-28 | Completed | ||
| Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567] | 42 participants (Actual) | Interventional | 2021-03-12 | Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.) | |||
| Double Blinded Study Ondansetron's Opposite Effect on Postoperative Analgesia of Acetaminophen[NCT02296333] | Phase 4 | 80 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Comparison of Tramadol vs. Tramadol With Paracetamol for Efficacy of Postoperative Pain Management in Lumbar Discectomy: A Randomised Controlled Trial[NCT03482492] | 60 participants (Actual) | Interventional | 2014-03-20 | Completed | |||
| Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093] | Phase 3 | 66 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| Analgesia Efficacy of Pre-operative and Post-operative PEC I/II Block for Bilateral Mastectomy With Reconstruction[NCT03653988] | 35 participants (Actual) | Interventional | 2019-03-12 | Completed | |||
| Comparison Between Serratus Anterior Plane Block, and Transversus Thoracic Plane Block Combined With Serratus Anterior Plane Block, for the Management of Post-mastecomy Pain.[NCT04375111] | 54 participants (Actual) | Interventional | 2021-06-15 | Completed | |||
| Efficacy of Pregabalin and Duloxetine in Patients With Painful Diabetic Peripheral Neuropathy (PDPN): the Effect of Pain on Cognitive Function, Sleep and Quality of Life (BLOSSOM)[NCT04246619] | Phase 4 | 254 participants (Actual) | Interventional | 2019-11-12 | Terminated (stopped due to The statistical analysis will still provide relevant results with the same statistical power as initially planned.COVID-19 pandemic prolonged the recruiting period and consequently affected the costs of the clinical trial.) | ||
| Phase III Clinical Trial Studying Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children[NCT02477007] | Phase 3 | 304 participants (Actual) | Interventional | 2015-12-03 | Completed | ||
| Effective Analgesia Using the 5 S's During Routine Immunizations at 2 and 4 Months[NCT01368861] | 230 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Childhood Immunization: Reducing Immunization Distress (RID) Using Multi-Modal Distraction[NCT01379885] | 77 participants (Actual) | Interventional | 2011-06-30 | Terminated (stopped due to Estimated sample size not achieved due to decline in number of eligible patients and difficulty recruiting and retaining research staff.) | |||
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| Self-compression Mammography in Clinical Practice: A Randomized Clinical Trial Compared to Standard Compression Mammography[NCT04009278] | 502 participants (Actual) | Interventional | 2018-01-25 | Completed | |||
| Clinical Response of Nuberol Forte® for the Pain Management in Musculoskeletal Disorders in Routine Pakistani Practice[NCT04765787] | 399 participants (Actual) | Observational | 2020-11-25 | Completed | |||
| Effectiveness of Percutaneous Microelectrolysis in the Decrease of Pain in Myofascial Trigger Points: Evaluation Through Algometry and Visual Analog Scale. Randomized Controlled Trial.[NCT03636386] | 48 participants (Actual) | Interventional | 2018-05-23 | Completed | |||
| MiniTightRope Suspensionplasty Compared With Ligamentous Reconstruction Tendon Interposition for the Treatment of Basilar Thumb Arthritis. A Randomized Clinical Trial[NCT02591368] | 7 participants (Actual) | Interventional | 2015-10-31 | Terminated | |||
| Arthroscopic Surgery Versus Non-surgical Treatment of Osteoarthritis of the Knee[NCT00158431] | Phase 3 | 186 participants (Actual) | Interventional | 1999-01-31 | Completed | ||
| Analgesic Effect of Ibuprofen 400 mg/Paracetamol 1000 mg, Ibuprofen 400 mg/ Paracetamol 1000 mg/60 mg Codeine, and Paracetamol 1000 mg/Codeine 60 mg: A Single-dose, Randomized, Placebo-controlled and Double-blind Study[NCT00921700] | Phase 4 | 200 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226] | Phase 4 | 31 participants (Actual) | Interventional | 2023-04-01 | Completed | ||
| Effect of Massage Therapy on Preoperative Anxiety and Postoperative Pain in Cancer Patients Undergoing Port Implantation[NCT00991770] | Phase 1 | 60 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547] | Phase 2 | 0 participants (Actual) | Interventional | 2016-07-14 | Withdrawn (stopped due to Lack of human ressources) | ||
| The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee[NCT00752765] | 30 participants (Anticipated) | Observational | 2008-09-30 | Completed | |||
| Pause and Breathe: Online Self-Help Mindfulness-Based Intervention: Investigation of Its Efficacy and Mechanism of Change[NCT05678972] | 939 participants (Actual) | Interventional | 2023-01-01 | Completed | |||
| Post-Operative Kinesio Taping Impact on Pain in Thoracotomy vs Thoracoscopy[NCT05200689] | 310 participants (Anticipated) | Interventional | 2022-01-09 | Recruiting | |||
| Stentless Florence Robotic Intracorporeal Neobladder (FloRIN)[NCT05891535] | 63 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | |||
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722772] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722811] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Inhaled Glucocorticoids for Acute Pharyngitis: A Randomized Clinical Trial[NCT04027322] | Phase 2/Phase 3 | 200 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| Impact of Direct Current Neuromuscular Electrical Stimulation on Physical Therapy Treatment of Peripheral Neuropathy[NCT05442021] | 148 participants (Actual) | Interventional | 2022-08-01 | Completed | |||
| The E-STIM Trial: A Randomized, Double-Blind, Multicenter Trial Comparing the Efficacy of the Empi Select Transcutaneous Electrical Nerve Stimulation (TENS) to a Control for the Treatment of Chronic Lower Back Pain[NCT00709748] | 300 participants (Anticipated) | Interventional | 2008-02-29 | Recruiting | |||
| Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery - an Exploratory Placebo-controlled Clinical Study to Investigate the Analgesic Properties of the Combination of Diclofenac [NCT03493490] | Phase 4 | 72 participants (Actual) | Interventional | 2018-03-01 | Completed | ||
| Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544] | 76 participants (Actual) | Interventional | 2019-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
reported on an 11-point numerical rating scale (NRS 0-10) where 0 indicates no pain and 10 indicates the most severe pain (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | units on a scale (Mean) |
|---|---|
| Pregabalin | 5.0 |
| Placebo | 5.5 |
summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | tablets (Median) |
|---|---|
| Pregabalin | 1 |
| Placebo | 2 |
summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | tablets (Median) |
|---|---|
| Pregabalin | 0 |
| Placebo | 0.5 |
A participant was included once if they ever reported a symptom during the 72 hour study period, not reflective of how long the symptom lasted. These were all commonly reported side effects during previous research on medication abortions and commonly reported side effects of pregabalin, so they were not included as adverse events. (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Nausea | Vomiting | Sleepiness | Dizziness | Headache | Blurred Vision | Diarrhea | Constipation | Dry Mouth | |
| Placebo | 42 | 30 | 39 | 26 | 17 | 7 | 29 | 15 | 25 |
| Pregabalin | 43 | 28 | 47 | 45 | 28 | 15 | 28 | 6 | 22 |
Participant pain was assessed using an 11-point Visual Analog Scale for Pain. Scores ranged from 0 (no pain) to 10 (worst pain possible) (NCT01457521)
Timeframe: 1-2 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Prophylactic | 7.1 |
| Therapeutic | 7.3 |
"Assessment of ankle pain by VAS: 100 mm horizontal line with left end being No Pain & right end being Worst Possible Pain. Participants drew vertical line on horizontal scale to best reflect current pain on full weight bearing of injured ankle. Distance from left end of line to mark. Change: mean score at day 3 minus mean score at baseline" (NCT00446797)
Timeframe: Baseline and day 3
| Intervention | scores on a scale (Mean) |
|---|---|
| Celecoxib | -44.88 |
| nsNSAIDs | -40.76 |
"Assessment of ankle pain by VAS: 100 mm horizontal line, left end being No Pain & right end being Worst Possible Pain. Participants drew vertical line on horizontal scale to best reflect current pain on full weight bearing of injured ankle. Distance from left end of line to mark. Change: mean score at observation minus mean score at baseline" (NCT00446797)
Timeframe: Baseline and days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 | Day 3 | Day 7 | |
| Celecoxib | -29.25 | -44.87 | -61.17 |
| nsNSAIDs | -25.98 | -40.75 | -57.89 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~The pain interference index is the average of pain interference questions 5A to 5G. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 4.07 | 2.79 | 1.28 |
| nsNSAIDs | 4.01 | 2.83 | 1.33 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5A: Subject response to 'how, during the past 24 hours, pain has interfered with your general activity. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 5.40 | 3.65 | 1.78 |
| nsNSAIDs | 5.37 | 4.07 | 1.90 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5B: Subject response to 'how, during the past 24 hours, pain has interfered with your mood'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 3.72 | 2.43 | 1.17 |
| nsNSAIDs | 3.64 | 2.38 | 1.26 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5C: Subject response to 'how, during the past 24 hours, pain has interfered with your walking ability'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 5.10 | 3.58 | 1.65 |
| nsNSAIDs | 5.11 | 3.69 | 1.62 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5D: Subject response to 'how, during the past 24 hours, pain has interfered with your normal work (work outside the home and housework)'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 5.29 | 4.04 | 1.84 |
| nsNSAIDs | 5.39 | 4.04 | 1.87 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5E: Subject response to 'how, during the past 24 hours, pain has interfered with your relations with other people'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 2.70 | 1.81 | 0.80 |
| nsNSAIDs | 2.67 | 1.69 | 0.78 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5F: Subject response to 'how, during the past 24 hours, pain has interfered with your sleep'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 2.97 | 1.90 | 0.68 |
| nsNSAIDs | 2.87 | 1.86 | 0.82 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q5G: Subject response to 'how, during the past 24 hours, pain has interfered with your enjoyment of life'. Scale: 0 = does not interfere to 10 = completely interferes" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 3.33 | 2.13 | 1.07 |
| nsNSAIDs | 2.99 | 2.06 | 1.10 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Pain severity index is the average of the pain severity questions 1 to 4. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 4.24 | 2.84 | 1.37 |
| nsNSAIDs | 4.48 | 3.26 | 1.68 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q1: Subject response to 'describe your pain at its worst in the last 24 hours'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 1, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 5.71 | 3.81 | 2.08 |
| nsNSAIDs | 5.90 | 4.44 | 2.38 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q2: Subject response to 'describe your pain at its least in the last 24 hours'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 133, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 3.25 | 2.07 | 0.83 |
| nsNSAIDs | 3.36 | 2.40 | 1.16 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q3: Subject response to 'describe your pain on the average'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N = 135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 4.34 | 2.90 | 1.41 |
| nsNSAIDs | 4.41 | 3.26 | 1.74 |
"m-BPI-sf questionnaire assessed pain severity and pain interference with functional activities during the 24 hour follow-up period.~Q4: Subject response to 'how much pain you have right now'. Scale: 0 = no pain to 10 = pain as bad as you can imagine" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Day 2 (N = 134, 133) | Day 3 (N =135, 131) | Day 7 (N = 133, 125) | |
| Celecoxib | 3.64 | 2.58 | 1.14 |
| nsNSAIDs | 4.23 | 2.92 | 1.43 |
The number of subjects showing a response: a decrease of at least 20 mm (that is improvement) on the pain visual analog scale (VAS) scale (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 2 - response (N=134, 133) | Day 2 - no response | Day 3 - response (N=135, 131) | Day 3 - no response | Day 7 - response (N=133, 125) | Day 7 - no response | |
| Celecoxib | 91 | 43 | 124 | 11 | 129 | 4 |
| nsNSAIDs | 79 | 54 | 116 | 15 | 120 | 5 |
"Subject's response to the statement My relief from starting pain is. Scale from 0 = None to 4 = Complete." (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | participants (Number) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 2 - None (N=135, 132) | Day 2 - A little | Day 2 - Some | Day 2 - A lot | Day 2 -Complete | Day 3 - None (N=135, 131) | Day 3 - A little | Day 3 - Some | Day 3 - A lot | Day 3 -Complete | Day 7 - None (N=133, 125) | Day 7 - A little | Day 7 - Some | Day 7 - A lot | Day 7 -Complete | |
| Celecoxib | 8 | 25 | 49 | 52 | 1 | 0 | 15 | 33 | 84 | 3 | 1 | 6 | 7 | 77 | 42 |
| nsNSAIDs | 5 | 33 | 52 | 42 | 0 | 1 | 21 | 46 | 60 | 3 | 1 | 3 | 15 | 80 | 26 |
Investigator evaluation of overall severity of ankle injury. Scale: 5 point from 1 = Very mild (very mild signs and symptoms of ankle sprain) to 5 =Very severe (very severe signs and symptoms of ankle sprain) (NCT00446797)
Timeframe: Days 3 and 7
| Intervention | participants (Number) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 3 - very mild (N=134, 131) | Day 3 - mild | Day 3 - moderate | Day 3 - severe | Day 3 - very severe | Day 7 - very mild (N=132, 125) | Day 7 - mild | Day 7 - moderate | Day 7 - severe | Day 7 - very severe | |
| Celecoxib | 20 | 71 | 40 | 2 | 1 | 87 | 38 | 7 | 0 | 0 |
| nsNSAIDs | 12 | 79 | 38 | 2 | 0 | 70 | 47 | 7 | 1 | 0 |
"Subject response to question: How does your ankle injury affect your walking and normal activity? Scale from 1 = Normal walking/activity and no pain to 5 = Severely restricted walking due to pain and can't resume normal activities (normal activities defined as all activity that a subject did on a routine basis, including work and recreation)" (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | participants (Number) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 2 - normal no pain (N =135, 133) | Day 2 - normal with pain | Day 2 - mildly restricted | Day 2 - moderately restricted | Day 2 - severely restricted | Day 3 - normal no pain (N = 135, 131) | Day 3 - normal with pain | Day 3 - mildly restricted | Day 3 - moderately restricted | Day 3 - severely restricted | Day 7 - normal no pain (N = 133, 125) | Day 7 - normal with pain | Day 7 - mildly restricted | Day 7 - moderately restricted | Day 7 - severely restricted | |
| Celecoxib | 5 | 40 | 59 | 19 | 12 | 18 | 52 | 49 | 14 | 2 | 62 | 55 | 11 | 4 | 1 |
| nsNSAIDs | 2 | 30 | 55 | 39 | 7 | 13 | 46 | 57 | 11 | 4 | 43 | 68 | 8 | 3 | 3 |
"Subject response to question: Considering all the ways your ankle injury affects you, how are you doing today? Scale: 5 point from 1 = very good (no symptoms and no limitation of normal activities) to 5 = very poor (very severe symptoms which are intolerable and inability to carry out all normal activities)." (NCT00446797)
Timeframe: Days 2, 3 and 7
| Intervention | participants (Number) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 2 - Very good (no symptoms) (N=135, 133) | Day 2 - Good (mild symptoms) | Day 2 - Fair (moderate symptoms) | Day 2 - Poor (severe symptoms) | Day 2- Very poor (very severe symptoms) | Day 3 - Very good (no symptoms) (N=135, 131) | Day 3 - Good (mild symptoms) | Day 3 - Fair (moderate symptoms) | Day 3 - Poor (severe symptoms) | Day 3 - Very poor (very severe symptoms) | Day 7 - Very good (no symptoms) (N=133, 125) | Day 7 - Good (mild symptoms) | Day 7 - Fair (moderate symptoms) | Day 7 - Poor (severe symptoms) | Day 7 - Very poor (very severe symptoms) | |
| Celecoxib | 1 | 40 | 76 | 17 | 1 | 8 | 68 | 54 | 5 | 0 | 53 | 61 | 17 | 2 | 0 |
| nsNSAIDs | 1 | 31 | 80 | 19 | 2 | 6 | 55 | 63 | 7 | 0 | 37 | 63 | 21 | 4 | 0 |
The need for additional analgesics (NCT01827475)
Timeframe: 1 hour
| Intervention | participants (Number) |
|---|---|
| Ibuprofen | 11 |
| Acetaminophen | 10 |
| Ibuprofen-acetaminophen Combination | 5 |
Pain score on 100 mm VAS from 0 (no pain) to 100 (worst pain) (NCT01827475)
Timeframe: 1 hour
| Intervention | mm (Mean) |
|---|---|
| Ibuprofen | 39 |
| Acetaminophen | 43 |
| Ibuprofen-acetaminophen Combination | 42 |
The primary outcome is pain measured at 24-hours after delivery. Patients will be asked to report a Visual Analog Scale (VAS) pain score at 24-hours after delivery. This scale ranges from 0 to 10 (0=no pain and 10=worst pain). (NCT01271855)
Timeframe: Twenty-four hours
| Intervention | units on a scale (Median) |
|---|---|
| Glycerin Suppository | 1 |
| Belladonna and Opioid Suppository | 2 |
Patients' satisfaction with their pain control is recorded at the time of discharge using a five point scale ranging from 1 (Not Satisfied) to 3 (Okay) to 5 (Very Satisfied). (NCT01271855)
Timeframe: Discharge
| Intervention | units on a scale (Median) |
|---|---|
| Glycerin Suppository | 4 |
| Belladonna and Opioid Suppository | 5 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Units on a scale (Mean) |
|---|---|
| Cellegesic (Nitroglycerin 0.4%) | -40.4 |
| Placebo | -34.9 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Percentage of responders (Number) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 72.4 | 88.6 |
| Placebo | 64.5 | 85.5 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21
| Intervention | Days (Mean) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 10.7 | 6.1 |
| Placebo | 13.2 | 7.2 |
Subjects were instructed to walk on the treadmill and to tell the research coordinator to stop testing when they reached the point at which they typically would need to stop and sit down, or until 15 minutes had elapsed. At defined intervals (every 30 seconds) subjects were asked what their pain level was according to the NRS. The area under the curve of present pain intensity is the total area combined for the amount of time the subject walked. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale * minutes (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 76.0 |
| Opana Then Placebo Then Darvocet | 95.7 |
| Placebo Then Opana Then Darvocet | 95.0 |
| Placebo Then Darvocet Then Opana | 86.4 |
| Darvocet Then Opana Then Placebo | 123.3 |
| Darvocet Then Placebo Then Opana | 79.6 |
Subjects were instructed to walk on the treadmill and to tell the research coordinator to stop testing when they reached the point at which they typically would need to stop and sit down, or until 15 minutes had elapsed. At defined intervals subjects were asked what their pain level was according to the NRS. When the subject reached their maximum distance, they were asked their NRS score. This was recorded as final pain intensity. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 4.6 |
| Opana Then Placebo Then Darvocet | 6.6 |
| Placebo Then Opana Then Darvocet | 6.2 |
| Placebo Then Darvocet Then Opana | 6.7 |
| Darvocet Then Opana Then Placebo | 8.0 |
| Darvocet Then Placebo Then Opana | 7.1 |
The mBPI is a series of questions that rates the severity and impact of pain on daily function. The questionnaire is made up of 4 pain severity items using the NRS scale, and seven 11-point pain interference scales (0 indicating no interference and 10 indicating complete interference). For the interference score, a total score of 10 indicates pain completely interferes with activities. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 3.7 |
| Opana Then Placebo Then Darvocet | 4.2 |
| Placebo Then Opana Then Darvocet | 2.7 |
| Placebo Then Darvocet Then Opana | 4.3 |
| Darvocet Then Opana Then Placebo | 6.2 |
| Darvocet Then Placebo Then Opana | 2.8 |
The ODI is a set of 10 questions each with five choices (maximum score of 5 points per question) designed to determine how back pain has affected the ability to manage everyday life (pain intensity, personal care, lifting, walking, sitting, standing, sleeping, social life, traveling, and change positions). A score of 0 indicates no disability and total score of 50 would indicate 100% disability. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 37.9 |
| Opana Then Placebo Then Darvocet | 98.4 |
| Placebo Then Opana Then Darvocet | 38.0 |
| Placebo Then Darvocet Then Opana | 44.1 |
| Darvocet Then Opana Then Placebo | 37.0 |
| Darvocet Then Placebo Then Opana | 29.7 |
Subjects were asked to rate their low back pain according to the PGA. PGA is the impact of disease activity. PGA was measured on a 5-point scale, where 1=very good, 2=good, 3=fair, 4=poor, and 5=very poor. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 2.8 |
| Opana Then Placebo Then Darvocet | 2.8 |
| Placebo Then Opana Then Darvocet | 3.1 |
| Placebo Then Darvocet Then Opana | 2.6 |
| Darvocet Then Opana Then Placebo | 3.3 |
| Darvocet Then Placebo Then Opana | 2.6 |
After the subject completed the treadmill test they were asked to immediately return to the seated position. At this point a timer was started. When the subjects pain level returned to baseline (level of pain subject felt in a seated position before walking) the time was stopped. This was recorded as recovery time. Maximum recovery time is 15 minutes. (NCT00652093)
Timeframe: study visit
| Intervention | minutes (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 1.10 |
| Opana Then Placebo Then Darvocet | 1.50 |
| Placebo Then Opana Then Darvocet | 2.02 |
| Placebo Then Darvocet Then Opana | 1.58 |
| Darvocet Then Opana Then Placebo | 2.15 |
| Darvocet Then Placebo Then Opana | 1.57 |
The RMDQ consists of 24 yes/no statements about activity limitations due to back pain. These questions center on movement, ambulation, and self-care activities. Positive (yes) answers each contribute 1 point to cumulative score with total scores ranging from 0 (no disability) to 24 (severely disabled). (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 12.8 |
| Opana Then Placebo Then Darvocet | 15.3 |
| Placebo Then Opana Then Darvocet | 13.2 |
| Placebo Then Darvocet Then Opana | 15.2 |
| Darvocet Then Opana Then Placebo | 13.7 |
| Darvocet Then Placebo Then Opana | 7.4 |
The SSS is a series of questions asking about symptom severity, physical function, and satisfaction. The physical function section is a series of 5 questions (maximum 4 points per question) and asks to rate function for each question based on comfortably, sometimes with pain, always with pain, no functional ability. The total score (max=20) is divided by five. The maximum score for the physical function section (max=4) indicates no ability to function. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 2.5 |
| Opana Then Placebo Then Darvocet | 2.5 |
| Placebo Then Opana Then Darvocet | 2.6 |
| Placebo Then Darvocet Then Opana | 2.6 |
| Darvocet Then Opana Then Placebo | 2.6 |
| Darvocet Then Placebo Then Opana | 2.2 |
The SSS is a series of questions asking about symptom severity, physical function, and satisfaction. The symptom severity section is a set of 7 questions (maximum score is 5 points per question) and asks to rate pain for each question based on no pain, mild, moderate, severe or very severe pain. The total score (maximum=35) is added up and divided by seven. The maximum score for the symptom severity section (score=5) indicates very severe symptom severity. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 2.6 |
| Opana Then Placebo Then Darvocet | 2.9 |
| Placebo Then Opana Then Darvocet | 3.2 |
| Placebo Then Darvocet Then Opana | 3.2 |
| Darvocet Then Opana Then Placebo | 3.6 |
| Darvocet Then Placebo Then Opana | 2.9 |
Using the Numeric Rating Scale (NRS) (0=no pain, 10=worst pain imaginable)the time to first symptoms (Tfirst) with a NRS score greater than or equal to 4 (moderate pain level), with treadmill ambulation was measured. Patients were excluded from the trial if there pain at rest was greater than or equal to 4/10. (NCT00652093)
Timeframe: study visit
| Intervention | minutes (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 1.73 |
| Opana Then Placebo Then Darvocet | 3.02 |
| Placebo Then Opana Then Darvocet | 3.93 |
| Placebo Then Darvocet Then Opana | 2.65 |
| Darvocet Then Opana Then Placebo | 0.83 |
| Darvocet Then Placebo Then Opana | 5.43 |
Subjects were instructed to walk on the treadmill and to tell the research coordinator to stop testing when they reached the point at which they typically would need to stop and sit down, or until 15 minutes had elapsed. When the subject reached their maximum distance, the treadmill testing was stopped. This was recorded as total distance based on number of minutes and seconds walked. Minutes was converted to meters based on calculation of defined speed of the treadmill. (NCT00652093)
Timeframe: study visit
| Intervention | meters (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 266.6 |
| Opana Then Placebo Then Darvocet | 249.5 |
| Placebo Then Opana Then Darvocet | 177.9 |
| Placebo Then Darvocet Then Opana | 290.1 |
| Darvocet Then Opana Then Placebo | 160.8 |
| Darvocet Then Placebo Then Opana | 294.8 |
The VAS asked subjects to place a mark indicative of their low back pain during the past day on a 100mm line, with 0mm representing no pain and 100mm representing extreme pain. (NCT00652093)
Timeframe: study visit
| Intervention | units on a scale (Mean) |
|---|---|
| Opana Then Darvocet Then Placebo | 51.3 |
| Opana Then Placebo Then Darvocet | 57.9 |
| Placebo Then Opana Then Darvocet | 56.2 |
| Placebo Then Darvocet Then Opana | 46.7 |
| Darvocet Then Opana Then Placebo | 63.3 |
| Darvocet Then Placebo Then Opana | 55.1 |
Paracetamol intake (500 mg), number of tablets per month. (NCT01342458)
Timeframe: 6 month
| Intervention | tablets per month (Median) |
|---|---|
| Intervention Group | 0 |
| Control Group | 10 |
The first peak of the external knee moment was calculated by mean inverse dynamics approach. To this procedure, we used the kinematics data of the lower limbs assessed with six infrared cameras and the ground reaction force evaluated by mean a force platform. This is a continuous measure. (NCT01342458)
Timeframe: 6 month
| Intervention | % body weight x height in centimeters (Mean) | |
|---|---|---|
| KAM (Baseline) | KAM (6th month) | |
| Control Group | 2.21 | 2.28 |
| Intervention Group | 2.44 | 2.37 |
This questionaire consists of three sections (eleven questions): about pain or discomfort, the maximum distance that the patient can walk, and activities of daily living. Scores range from zero to twenty-four, meaning cases without involvement and with extremely severe impairment, respectively. (NCT01342458)
Timeframe: 6 month
| Intervention | score (Mean) | ||
|---|---|---|---|
| Lequesne (Baseline) | Lequesne (3rd month) | Lequesne (6th month) | |
| Control Group | 11.5 | 8.9 | 9.7 |
| Intervention Group | 9.7 | 6.3 | 5.5 |
The six-minute walk test assesses distance in meters walked over 6 minutes. (NCT01342458)
Timeframe: 6 month
| Intervention | meter (Mean) | ||
|---|---|---|---|
| Six-minute walk test (Baseline) | Six-minute walk test (3rd month) | Six-minute walk test (6th month) | |
| Control Group | 430.6 | 431.6 | 428.3 |
| Intervention Group | 433.5 | 453.5 | 439.3 |
The WOMAC (Western Ontario and McMaster Universities) pain subscale consists of five questions (Likert Scale) relating to the patient's pain in everyday situations. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items of pain subscale ranges from 0 to 20. Higher scores indicate worse pain. (NCT01342458)
Timeframe: 6 month
| Intervention | score (Mean) | ||
|---|---|---|---|
| WOMAC pain (Baseline) | WOMAC pain (3rd month) | WOMAC pain (6th month) | |
| Control Group | 10.0 | 6.6 | 7.2 |
| Intervention Group | 9.2 | 4.5 | 3.1 |
The physical function subscale included in the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) index consists of seventeen questions (Likert Scale) relating to the patient's physical activities, or skills to move out and take care of themselves. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items of physical function subscale ranges from 0 to 68. Higher scores on the physical function WOMAC subscale indicate worse functional limitations. (NCT01342458)
Timeframe: 6 month
| Intervention | score (Mean) | ||
|---|---|---|---|
| WOMAC Physical function subscale (Baseline) | WOMAC Physical function subscale (3rd month) | WOMAC Physical function subscale (6 month) | |
| Control Group | 29.6 | 20.9 | 23.9 |
| Intervention Group | 27.6 | 13.2 | 10.2 |
The stiffness subscale included in the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) index consists of two questions (Likert Scale) relating articular function of the patient. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items of the stiffness subscale ranges from 0 to 8. Higher scores on the stiffness WOMAC subscale indicate worse articular function. (NCT01342458)
Timeframe: 6 month
| Intervention | score (Mean) | ||
|---|---|---|---|
| WOMAC Stiffness subscale (Baseline) | WOMAC Stiffness subscale (3rd month) | WOMAC Stiffness subscale (6th month) | |
| Control Group | 2.4 | 2.9 | 2.0 |
| Intervention Group | 1.8 | 0.8 | 0.7 |
The WOMAC total score is the sum of all subscale (pain, function and stiffness) (Likert Scale) relating to the patient's physical activities, or skills to move out and take care of themselves. The Likert Scale version used for all WOMAC items are: none, mild, moderate, severe, and extreme. The sum of all items ranges from 0 to 96. Higher scores on the WOMAC total score indicate worse condition. (NCT01342458)
Timeframe: 6 month
| Intervention | score (Mean) | ||
|---|---|---|---|
| WOMAC total score (Baseline) | WOMAC total score (3rd month) | WOMAC total score (6th month) | |
| Control Group | 42.0 | 30.4 | 33.8 |
| Intervention Group | 37.7 | 17.6 | 14.3 |
"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Weeks 2, 6, and 12 minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -23.78 |
| Meloxicam 10 mg Once Daily | -21.70 |
| Placebo | -13.26 |
"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference was calculated as the WOMAC pain subscale score assessed at Weeks 2, 6, and 12 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -30.51 |
| Meloxicam 10 mg Once Daily | -27.89 |
| Placebo | -20.07 |
"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total (composite) WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Weeks 2, 6, and 12 minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -25.15 |
| Meloxicam 10 mg Once Daily | -22.83 |
| Placebo | -14.67 |
"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Weeks 2, 6, and 12 minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -24.76 |
| Meloxicam 10 mg Once Daily | -21.33 |
| Placebo | -13.09 |
"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Week 12/early termination minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -28.21 |
| Meloxicam 10 mg Once Daily | -28.40 |
| Placebo | -17.95 |
"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference is calculated as the WOMAC pain subscale score assessed at Week 12 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -36.52 |
| Meloxicam 10 mg Once Daily | -34.41 |
| Placebo | -25.68 |
"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Week 12/early termination minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -29.85 |
| Meloxicam 10 mg Once Daily | -29.71 |
| Placebo | -19.72 |
"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Week 12/early termination minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 12/Early Termination
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -29.68 |
| Meloxicam 10 mg Once Daily | -28.10 |
| Placebo | -18.74 |
"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Week 2 minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -20.45 |
| Meloxicam 10 mg Once Daily | -14.41 |
| Placebo | -10.00 |
"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference was calculated as the WOMAC pain subscale score assessed at Week 2 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -26.12 |
| Meloxicam 10 mg Once Daily | -20.42 |
| Placebo | -16.51 |
"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Week 2 minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -21.62 |
| Meloxicam 10 mg Once Daily | -15.67 |
| Placebo | -11.28 |
"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Week 2 minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 2
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -19.84 |
| Meloxicam 10 mg Once Daily | -14.88 |
| Placebo | -8.86 |
"The function in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale score. The WOMAC function subscale score is calculated as the mean of the visual analogue scale scores from 17 function subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their functional limitation level over the last 24 hours, with 0 mm meaning No Functional Limitation and 100 mm meaning Extreme Functional Limitation.~The WOMAC function subscale score difference was calculated as the WOMAC function subscale score assessed at Week 6 minus the WOMAC function subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -24.41 |
| Meloxicam 10 mg Once Daily | -24.38 |
| Placebo | -14.73 |
"The pain in subjects with osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score. The WOMAC pain subscale score is calculated as the average of the visual analogue scale (VAS) scores from 5 pain subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their pain level over the last 24 hours, with 0 mm representing No Pain and 100 mm representing Extreme Pain.~The WOMAC pain subscale score difference was calculated as the WOMAC pain subscale score assessed at Week 6 minus the WOMAC pain subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -31.31 |
| Meloxicam 10 mg Once Daily | -30.82 |
| Placebo | -20.98 |
"Pain, stiffness, and function in subjects with osteoarthritis were measured using the Western Ontario and McMaster Universities (WOMAC) Index, which is a 24-item questionnaire. The total WOMAC score is calculated as the average of the mean visual analogue scale (VAS) scores from the questions in the pain, stiffness, and function subscales. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their response to each of the questions, with 0 mm representing No Pain, Stiffness, or Difficulty and 100 mm representing Extreme Pain, Stiffness, and Difficulty.~The total WOMAC score difference was calculated as the total WOMAC score assessed at Week 6 minus the total WOMAC score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -25.86 |
| Meloxicam 10 mg Once Daily | -25.45 |
| Placebo | -16.03 |
"The stiffness in osteoarthritis subjects within the past 24 hours was measured at baseline using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness subscale score. The WOMAC stiffness subscale score is calculated as the mean of the visual analogue scale scores from 2 stiffness subscale questions. Subjects mark the VAS, which is a horizontal line 100 mm in length, with a single vertical line to indicate their stiffness level over the last 24 hours, with 0 mm meaning No Stiffness and 100 mm meaning Extreme Stiffness.~The WOMAC stiffness subscale score difference was calculated as the WOMAC stiffness subscale score assessed at Week 6 minus the WOMAC stiffness subscale score assessed at baseline." (NCT01787188)
Timeframe: Baseline to Week 6
| Intervention | mm (Least Squares Mean) |
|---|---|
| Meloxicam 5 mg Once Daily | -26.52 |
| Meloxicam 10 mg Once Daily | -23.39 |
| Placebo | -14.30 |
proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | proportion of days (Mean) |
|---|---|
| Acetaminophen | .86 |
| Ibuprofen | .87 |
average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | inhalations per week (Mean) |
|---|---|
| Acetaminophen | 2.8 |
| Ibuprofen | 3 |
the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | asthma exacerbations per 46 weeks (Mean) |
|---|---|
| Acetaminophen | 0.81 |
| Ibuprofen | .87 |
frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | unscheduled health visits per 46 weeks (Mean) |
|---|---|
| Acetaminophen | .75 |
| Ibuprofen | .76 |
Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.
| Intervention | days (Median) |
|---|---|
| Capital® With Codeine Suspension | 1.5 |
| Tramadol Suspension | 1 |
Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.
| Intervention | participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea | Vomiting | Fever | Itching | Rash | Sweating | Dizziness | Headache | Constipation | Oversedation | Tonsil bleed | |
| Capital® With Codeine Suspension | 20 | 21 | 11 | 5 | 1 | 9 | 15 | 12 | 21 | 14 | 3 |
| Tramadol Suspension | 20 | 18 | 10 | 12 | 1 | 7 | 17 | 17 | 21 | 8 | 0 |
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.
| Intervention | mmol/L (Mean) | |
|---|---|---|
| Lactate before pushups | Lactate after pushups | |
| Compound Exercise of Push-ups | 1.51 | 7.69 |
Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | |
| Compound Exercise of Push-ups | .14 | .19 | .13 |
| Ibuprofen | .39 | .56 | .28 |
| Placebo | .19 | .22 | .06 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 214.80 | 345.09 |
| Ibuprofen | 171.00 | 239.25 |
| Placebo | 216.75 | 343.03 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 149.22 | 232.58 |
| Ibuprofen | 177.78 | 243.13 |
| Placebo | 221.09 | 296.66 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 26.00 | 41.02 |
| Ibuprofen | 17.41 | 25.47 |
| Placebo | 26.09 | 34.09 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 32.89 | 49.07 |
| Ibuprofen | 40.16 | 47.34 |
| Placebo | 36.69 | 44.78 |
Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes,rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following the first treatment on Day 1, PI was similarly measured over a 20 minute high-paced treadmill walk at 5 hrs post-dose. A high-paced walk is the highest pace that can be walked safely for at least 5 minutes that is at a 10-30% higher rate than a self-paced walk. The difference between the TWA (0-20 minutes) PI determined at baseline, and the TWA (0-20 minutes) PI of the high-paced walk on Day 1 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 1
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 0.150 |
| Naproxen | -0.508 |
| Ultracet | -1.00 |
Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes, rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following a single treatment on Day 3, PI was similarly measured over a 20 minute high-paced treadmill walk, at 5 hrs post-dose. A high-paced walk is the highest pace that can be walked safely for at least 5 minutes that is at a 10-30% higher rate than a self-paced walk. The difference between the TWA (0-20 minutes) PI determined at baseline, and the TWA (0-20 minutes) PI of the high-paced walk on Day 3 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 3
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | -0.234 |
| Naproxen | -1.11 |
| Ultracet | -1.30 |
Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes, rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following the first treatment on Day 1, PI was similarly measured over 20 minute self-paced walks at 2, 4, and 6 hrs post-dose . The difference between the TWA (0-20 minutes) PI determined at baseline, and the average of the three TWA (0-20 minutes)PI from the self-paced walks on Day 1 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 1
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | -0.438 |
| Naproxen | -0.956 |
| Ultracet | -1.47 |
Baseline measurements of participant-specific knee PI were gathered pre-dose on Day 1 from the briskest possible self-pace constant walks on a treadmill over the course of a 20 minute interval. Over this interval PI readings were taken at time points 0,3,6,9,12,15,18 and 20 minutes, rated on an 11-point numeric rating scale (NRS), with 0: No Pain - 10: Worst Pain You Can Imagine. Following a single treatment on Day 3, PI was similarly measured over 20 minute self paced walks at 4 and 6 hrs post-dose. The difference between the TWA (0-20 minutes) PI determined at baseline, and the average of the two TWA (0-20 minutes) PI from the self-paced walks on Day 3 is reported as units on a scale. (NCT00772967)
Timeframe: Baseline and Day 3
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | -0.927 |
| Naproxen | -1.54 |
| Ultracet | -1.73 |
"Pain intensities(PIs) were measured at pre-dose and 3 post-dose walks (15 Minutes Each Separated by a 45-Minute Rest Interval) on an 11 point scale(0=no pain; 10=worst pain) and averaged for each walk.~Change from baseline was average of post-dose PIs minus average of pre-dose PI." (NCT00565084)
Timeframe: All pain intensities measured from the pre-treatment walk and 3 post-treatment walks (within 3 and half hours post dose, 15 minutes each walk separated by a 45-minute rest interval)
| Intervention | Units on a Scale (Least Squares Mean) |
|---|---|
| Ibuprofen | 0.24 |
| Placebo 1 | 0.18 |
| Placebo 2 | 0.18 |
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | -0.01 |
| Acetaminophen | -0.8 |
2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | BPM (Mean) |
|---|---|
| Normal Saline Placebo | 2 |
| Acetaminophen | -6 |
2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | -0.1 |
| Acetaminophen | -24 |
time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | 38.4 |
| Acetaminophen | 37.9 |
time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | beats per minute (Mean) |
|---|---|
| Normal Saline Placebo | 92 |
| Acetaminophen | 87 |
time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | breaths per minute (Mean) |
|---|---|
| Normal Saline Placebo | 22 |
| Acetaminophen | 21 |
time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | 143 |
| Acetaminophen | 127 |
"Ten likert-type questions assessing user-friendliness of technology. Each question has five answer options that range from Strongly Agree to Strongly Disagree. Scores range from 0-100. A score of 68 or above is considered above average. All scores averaged." (NCT03291613)
Timeframe: After 1-hour usability session
| Intervention | units on a scale (Mean) |
|---|---|
| Pinpoint App | 86.67 |
Magnitude of pain expressed in millimeters (mm) referred by participants. PI was evaluated through visual analogue scale at moment of performing pressure algometry test in the sensitive point of upper trapezius muscle. PI was assessed with an analogous visual scale where the participant will mark the pain generated by the algometry on a scale of 1 to 100 millimeters. PI was valued in four occasions: PI1 pre (baseline), PI1 post, PI 2 (at day 3) and PI 3 (at day 7). (NCT03636386)
Timeframe: PIpre1 (baseline), PIpost1 (post baseline), PI2 (Day 3), PI3 (Day 7), assessed an average of 3 minutes at each session
| Intervention | mm (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| PIpre1 | PIpost1 | PI2 | PI3 | PIdiff1-1 | PIdiff2-1 | PIdiff3-1 | |
| Control Group (Ultrasound Therapy) | 31.4 | 24.8 | 23.8 | 20.0 | -6.6 | -7.6 | -11.5 |
| Percutaneous Microelectrolysis Group (MEP) | 32.1 | 24.6 | 21.6 | 18.1 | -7.5 | -10.5 | -14.0 |
Pain Intensity expressed in kilograms per square centimeter(kg/cm2) reported by participants when performing algometry test at sensitive point of upper trapezius muscle. PPT was valued in four occasions: PPT1 pre (baseline), PPT1 post, PPT 2 (at day 3) and PPT 3 (at day 7). PPT will be evaluated through the BASELINE® pressure algometer. (NCT03636386)
Timeframe: PPTpre1 (baseline), PPTpost1 (post baseline), PPT2 (Day 3), PPT3 (Day 7), assessed an average of 30 minutes at each session
| Intervention | Kg/cm2 (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| PPTpre1 | PPTpost1 | PPT2 | PPT3 | PPTdiff1-1 | PPTdiff2-1 | PPTdiff3-1 | |
| Control Group (Ultrasound Therapy) | 1.4 | 1.6 | 1.6 | 1.7 | 0.2 | 0.2 | 0.3 |
| Percutaneous Microelectrolysis Group (MEP) | 1.4 | 1.6 | 1.7 | 1.9 | 0.2 | 0.4 | 0.5 |
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
235 reviews available for acetaminophen and Ache
| Article | Year |
|---|---|
The efficacy and safety of acetaminophen use following liver resection: a systematic review.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Hepatectomy; Humans; Liver; Morphine; Observational Studie | 2022 |
Perioperative Buprenorphine Management: A Multidisciplinary Approach.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2022 |
Deprescribing paracetamol in pain conditions: A scoping review.
Topics: Acetaminophen; Adult; Deprescriptions; Humans; Pain; Prospective Studies | 2022 |
Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cisplatin; Humans; Pain | 2021 |
Sterile water injections for management of renal colic pain: a systematic review.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Morphine Derivatives; Pa | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Analgesia for retinopathy of prematurity screening: A systematic review.
Topics: Acetaminophen; Analgesia; Fentanyl; Humans; Infant, Newborn; Nitrous Oxide; Pain; Pain Measurement; | 2022 |
Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ca | 2022 |
Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pain; Quality of Lif | 2022 |
Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Exercise Therapy; Humans; | 2023 |
Pharmacokinetic and pharmacodynamic herb-drug interactions of common over-the-counter pain medications.
Topics: Acetaminophen; Aspirin; Herb-Drug Interactions; Humans; Ibuprofen; Naproxen; Pain | 2023 |
Common Selfcare Indications of Pain Medications in Children.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; COVID-19; Fever; Humans; Ibuprofen; Pain | 2023 |
In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis.
Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Child; Europe; Humans; Pain; Prospecti | 2023 |
Evidence-based labor management: postpartum care after vaginal delivery (part 6).
Topics: Acetaminophen; Anticoagulants; Delivery, Obstetric; Female; Humans; Infant; Pain; Postnatal Care; Pr | 2023 |
Identifying Residents Who May Benefit from an Analgesic Review: Applying Analgesic Indicators in Residential Aged Care Services.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Australia; Cross-Sectional Studies; Female; Hum | 2023 |
Is coadministration of preemptive medications an effective strategy for reducing inflammatory clinical events and the need for rescue medication after mandibular third molar surgery? A systematic review of randomized clinical trials.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Molar, Third; Pain; Rand | 2023 |
A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis.
Topics: Acetaminophen; Arthritis, Juvenile; Child; Humans; Pain; Pain Management; Quality of Life | 2023 |
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, N | 2023 |
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; | 2023 |
Breastfeeding or breast milk for procedural pain in neonates.
Topics: Acetaminophen; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Milk, Human; Pain; Pain, Pro | 2023 |
Network meta-analysis of randomized controlled trials comparing the effectiveness of different treatments in reducing amniocentesis-associated pain and anxiety.
Topics: Acetaminophen; Amniocentesis; Anxiety; Female; Humans; Network Meta-Analysis; Pain; Pregnancy; Rando | 2023 |
Antiinflammatory Drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Pain; Pain Management | 2019 |
Pain Management Protocols During Uterine Fibroid Embolisation: A Systematic Review of the Evidence.
Topics: Acetaminophen; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age | 2019 |
Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; C | 2019 |
Do analgesics used for the pain experienced after orthodontic procedures affect tooth movement rate? A systematic review based on animal studies.
Topics: Acetaminophen; Analgesics; Animals; Humans; Pain; Tooth Movement Techniques | 2020 |
Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2019 |
Nonprescription drugs recommended in guidelines for common pain conditions.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2020 |
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Infant, Newborn; Pain; Pain Management; Randomized | 2020 |
Pharmacotherapy for knee osteoarthritis: current and emerging therapies.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agen | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Infl | 2020 |
Systematic review and meta-analysis of oral paracetamol versus combination oral analgesics for acute musculoskeletal injuries.
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammator | 2021 |
The efficacy of analgesics in controlling orthodontic pain: a systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics; Humans; Ibuprofen; Pain; Pain Management | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Relief of pain due to uterine cramping/involution after birth.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Fever; Humans; Ibu | 2020 |
Opioid Use and Misuse in Pregnancy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory A | 2020 |
The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Craniotomy; Data Management; Humans; | 2021 |
Ibuprofen vs. Acetaminophen for Fever or Pain in Children Younger Than Two Years.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Ibuprofen; Infant; Pain; Patient Selection; | 2021 |
Pharmacological Means of Pain Control during Separator Placement: A Systematic Review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Ibuprofen; Pain; Pain Management; Pain Measurement; | 2021 |
Paracetamol: unconventional uses of a well-known drug.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Illicit Drugs; Pain | 2021 |
[Revision of the Dutch College of General Practitioners practice guideline 'Children with fever'].
Topics: Acetaminophen; Child; Family Practice; Fever; General Practitioners; Humans; Ibuprofen; Netherlands; | 2017 |
Improving the treatment of infant pain.
Topics: Acetaminophen; Administration, Cutaneous; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroida | 2017 |
What is the best analgesic option for patients presenting with renal colic to the emergency department? Protocol for a systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Checklist; C | 2017 |
Perinatal and neonatal use of paracetamol for pain relief.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Infant, Newborn; Pain; Pain Management; Pre | 2017 |
Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Decision Trees; Dose-Response Relationship, Drug; Humans; I | 2017 |
NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Me | 2018 |
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Meta-Analysis; Osteoarthriti | 2018 |
Commonly used nonopioid analgesics in adults.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Non | 2018 |
What dose of paracetamol for older people?
Topics: Acetaminophen; Age Factors; Aged, 80 and over; Analgesics; Chemical and Drug Induced Liver Injury; D | 2018 |
Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations.
Topics: Acetaminophen; Adaptation, Physiological; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Ag | 2018 |
Can I take my normal painkillers doctor? Therapeutic management of pain following dermatological procedures.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2019 |
[Pharmacological Basis of Pain Treatment].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Dipy | 2018 |
Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2018 |
Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies.
Topics: Acetaminophen; Analgesics; Animals; Humans; Ibuprofen; Pain; Tooth Movement Techniques | 2019 |
Pain Management in Trauma in the Age of the Opioid Crisis.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Gabapentin; Humans | 2019 |
Pain assessment and pain treatment for community-dwelling people with dementia: A systematic review and narrative synthesis.
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Dementia; Humans | 2019 |
Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review.
Topics: Acetaminophen; Adolescent; Adult; Child; Dental Care; Female; Humans; Ibuprofen; Middle Aged; Orthod | 2019 |
Intravenous Acetaminophen-Induced Hypotension: A Review of the Current Literature.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Blood Pressure; Critical Illne | 2019 |
A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Liver Diseases; Pain | 2018 |
Paracetamol versus other analgesia in adult patients with minor musculoskeletal injuries: a systematic review.
Topics: Acetaminophen; Adult; Analgesia; Analgesics; Humans; Musculoskeletal Diseases; Pain; Pain Management | 2019 |
Medication Use and Pain Management in Pregnancy: A Critical Review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug | 2019 |
Benzhydrocodone/acetaminophen (Apadaz) for pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Humans; Hydrocodone; | 2019 |
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain | 2013 |
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain | 2013 |
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain | 2013 |
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain | 2013 |
Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2013 |
Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.
Topics: Acetaminophen; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclohexaneca | 2013 |
Neonatal pain.
Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag | 2014 |
Neonatal pain.
Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag | 2014 |
Neonatal pain.
Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag | 2014 |
Neonatal pain.
Topics: Acetaminophen; Analgesics, Opioid; Anesthesia, Conduction; Humans; Infant, Newborn; Pain; Pain Manag | 2014 |
Paracetamol: a focus for the general pediatrician.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Fever; Humans; Pain; Risk Factors | 2014 |
[Risks and benefits of paracetamol in children with fever].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Pain; Risk Assessme | 2014 |
An overview of pain management: the clinical efficacy and value of treatment.
Topics: Acetaminophen; Acute Disease; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic P | 2013 |
Changes coming in pain management?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Approval; Humans; Pain; Pain Management; Pain Measurem | 2014 |
Acute perioperative pain in neonates: An evidence-based review of neurophysiology and management.
Topics: Acetaminophen; Acute Disease; Analgesia; Analgesics, Opioid; Anesthesia, Epidural; Evidence-Based Me | 2014 |
[A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl].
Topics: Acetaminophen; Amines; Child; Cyclohexanecarboxylic Acids; Drug Combinations; Fentanyl; Gabapentin; | 2014 |
Codeine, alone and with paracetamol (acetaminophen), for cancer pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combinati | 2014 |
[Paracetamol-codeine, an always actual choice for the treatment of pain].
Topics: Acetaminophen; Activation, Metabolic; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; | 2014 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Codeine; Drug Comb | 2015 |
Intravenous acetaminophen use in pediatrics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bicycling; Body Weight; Chemic | 2015 |
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Infant, Newborn; Pain; Randomized Controlled Trials | 2015 |
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Analgesics, Opioid; Anti-Inflammator | 2015 |
WITHDRAWN: NSAIDS or paracetamol, alone or combined with opioids, for cancer pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2015 |
[Analgesia in patients with hepatic impairment].
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; H | 2015 |
Pain management in patients with hidradenitis suppurativa.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics; Anti-Inflammatory A | 2015 |
Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Androstanols; Anesthetics, Local; Child; Fentanyl; Humans; | 2016 |
A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements; Disease Progression; Gl | 2016 |
Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Commerce; | 2016 |
Oral NSAIDs versus other oral analgesic agents for acute soft tissue injury.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-S | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Delivery, Obstetric; Diagnostic Techniques, Ophthalmologica | 2016 |
Analgesia in the surgical intensive care unit.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C | 2017 |
Paracetamol and morphine for infant and neonatal pain; still a long way to go?
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Humans; Infant; I | 2017 |
Clinical update on benefit versus risks of oral paracetamol alone or with codeine: still a good option?
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory | 2017 |
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age | 2016 |
Comparing the effectiveness profile of pharmacological interventions used for orthodontic pain relief: an arm-based multilevel network meta-analysis of longitudinal data.
Topics: Acetaminophen; Analgesics; Drug Administration Schedule; Etoricoxib; Humans; Ibuprofen; Network Meta | 2017 |
Paracetamol/Tramadol association: the easy solution for mild-moderate pain.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Th | 2008 |
Effectiveness of oral vs rectal acetaminophen: a meta-analysis.
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Child; Fever; | 2008 |
[The combination acetominophen/tramadol in hematological daily practice].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biopsy, Fine-Needle; Bone Marrow; Drug Therapy, Combination | 2008 |
Intravenous paracetamol (acetaminophen).
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Controlled Clinical Trials as Topic; Fever; H | 2009 |
Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists.
Topics: Acetaminophen; Age Factors; Analgesics; Anesthesiology; Biological Availability; Cyclooxygenase Inhi | 2008 |
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Clinical safety and tolerability of ibuprofen compared with paracetamol in pediatric pain and fever. A systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Ibuprofen; Pain | 2009 |
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review.
Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Female; Fever; Humans; Ibuprofen | 2010 |
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
Topics: Acetaminophen; Acute Disease; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Female; Humans; Pain | 2010 |
Pain management in the cirrhotic patient: the clinical challenge.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2010 |
[Treatment of acute pain during drug-assisted rehabilitation].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents | 2010 |
Oxycodone combinations for pain relief.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspi | 2010 |
A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Caffeine; Central Nervous System Stimulants; Datab | 2010 |
Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Drug Synergism; Huma | 2010 |
Tramadol/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe pain.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations | 2010 |
Osteoarthritis: a review of treatment options.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Methylxanthines and pain.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interact | 2011 |
Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Analgesics, Non-Narcotic; Emergency Service, Hospita | 2011 |
What do we (not) know about how paracetamol (acetaminophen) works?
Topics: Acetaminophen; Acetanilides; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2010 |
[Solutions for the clinical problems of analgesics for cancer pain treatment in Japan].
Topics: Acetaminophen; Analgesics; Drug Administration Routes; Fentanyl; Humans; Japan; Neoplasms; Oxycodone | 2011 |
Pharmacotherapy for acute pain in children: current practice and recent advances.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, | 2011 |
[Analgesia for pediatric patients. Standards and special aspects].
Topics: Acetaminophen; Adolescent; Analgesia; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti | 2011 |
Assessment of acute and persistent pain management in patients with haemophilia.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, | 2011 |
Analgosedation in neonates: do we still need additional tools after 30 years of clinical research?
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Analgesia; Analgesics, Opioid; Dexmedetomidine; | 2011 |
Intravenous acetaminophen (Ofirmev).
Topics: Acetaminophen; Animals; Chemistry, Pharmaceutical; Drug Approval; Humans; Infusions, Intravenous; In | 2011 |
Clinical inquiries. Which treatments provide the most relief for pharyngitis pain?
Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Evidenc | 2011 |
Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Common Cold; Double-Blind Me | 2011 |
Management of chronic noncancer pain in depressed patients.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2011 |
Acetaminophen injection: a review of clinical information.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Child, P | 2011 |
The role of paracetamol and nonsteroidal anti-inflammatory drugs in addition to WHO Step III opioids in the control of pain in advanced cancer. A systematic review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2012 |
Acetaminophen injection: a review of clinical information including forms not available in the United States.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Trials as Topic; Humans; Injections, Intravenous; | 2012 |
Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold.
Topics: Acetaminophen; Aspirin; Common Cold; Dyspepsia; Fever; Gastrointestinal Tract; Humans; Ibuprofen; No | 2012 |
Nonsteroidal antiinflammatory drugs, acetaminophen, and hypertension.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox | 2012 |
Pharmaceutical therapy for osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 I | 2012 |
The effect of paracetamol and tropisetron on pain: experimental studies and a review of published data.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cross-Over Studies; Double-Blind Method; Dr | 2013 |
Paracetamol for the management of pain in inflammatory arthritis: a systematic literature review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis; Clinical Trials as Topic; Evidence-Based Medicin | 2012 |
Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agen | 2012 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2012 |
Optimising the management of fever and pain in children.
Topics: Acetaminophen; Analgesics; Child; Comparative Effectiveness Research; Dose-Response Relationship, Dr | 2013 |
Perioperative pain control in pediatric patients undergoing orthopaedic surgery.
Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory | 2012 |
The long and winding road of non steroidal antinflammatory drugs and paracetamol in cancer pain management: a critical review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms; | 2013 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Analgesics for the treatment of pain in children.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; A | 2002 |
Rational use of analgesic combinations.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2002 |
[Efficacy and safety of acetaminophen-codeine in the treatment of pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combination; Hum | 2002 |
Demographics, assessment and management of pain in the elderly.
Topics: Acetaminophen; Adrenal Cortex Hormones; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agen | 2003 |
Interventions for relieving the pain and discomfort of screening mammography.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Mammography; Pain; Premedication; Pressure; | 2002 |
Pain management in children with sickle cell disease.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; | 2003 |
Treating osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitor | 2003 |
Tramadol/paracetamol.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics; Biological Availability; Chronic Dis | 2003 |
The new analgesic combination tramadol/acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Humans; Pain; Tramad | 2003 |
A pictorial and video guide to circumcision without pain.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Local; Attitude of Heal | 2003 |
Analgesia in patients with ESRD: a review of available evidence.
Topics: Acetaminophen; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anti- | 2003 |
Nonopioid and adjuvant analgesics in chronic pain management: strategies for effective use.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal | 2003 |
[Antinociceptive mechanism of action of paracetamol].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2003 |
[Pharmacologic basis for using paracetamol: pharmacokinetic and pharmacodynamic issues].
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adolescent; Adult; Age Factors; Analges | 2003 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
[Pain management: health economics and quality of life considerations].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cost Control; Cost of Illness; Drug Costs; Humans; Pain; Qu | 2003 |
[Role of paracetamol in the acute pain management].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Clinical Trials as Topic; Humans; Pain | 2003 |
[New perspectives on paracetamol].
Topics: Acetaminophen; Administration, Oral; Advertising; Analgesics, Non-Narcotic; Chemical and Drug Induce | 2003 |
Translating research into practice: acetaminophen in osteoarthritis revisited.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Pain | 2004 |
Pharmacological management of head and neck pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Head; Humans; Neck; Pain | 2003 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Pharmacological techniques for managing acute pain in emergency departments.
Topics: Acetaminophen; Acute Disease; Adult; Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Local; A | 2004 |
Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Ibuprof | 2004 |
Acetaminophen as symptomatic treatment of pain from osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinica | 2004 |
[Problem forte--is paracetamol-codeine combination rational?].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Codeine | 2004 |
[Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Costs and Cost Analysis; Cyclooxygenase 2; Cyclooxygenase 2 | 2004 |
NSAIDS or paracetamol, alone or combined with opioids, for cancer pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2005 |
Oral analgesics for acute nonspecific pain.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Algorithms; Analgesics, Non-Narcotic; Aspirin; H | 2005 |
Basic pharmacology and advances in emergency medicine.
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; C | 2005 |
Valdecoxib for the management of chronic and acute pain.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chr | 2005 |
Rheumatic diseases in the elderly: dealing with rheumatic pain in extended care facilities.
Topics: Acetaminophen; Aged; Algorithms; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2005 |
Drugs for pain management in dentistry.
Topics: Acetaminophen; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Dental Care; Humans | 2005 |
Cancer-related pain and its pharmacologic management in the patient with bone metastasis.
Topics: Acetaminophen; Analgesics; Bone Neoplasms; Diphosphonates; Humans; Narcotics; Neoplasm Metastasis; P | 2006 |
Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2006 |
Nonnarcotic analgesics and hypertension.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pre | 2006 |
Gastrointestinal Considerations in Patients with Cardiovascular Disease Using Nonopioid Analgesics for Mild-to-Moderate Pain or Cardioprotection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 Inhibito | 2006 |
Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Cyclo | 2006 |
Pain control: non-steroidal anti-inflammatory agents.
Topics: Absorption; Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug | 2006 |
Update on guidelines for the treatment of chronic musculoskeletal pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
Combination analgesia in 2005 - a rational approach: focus on paracetamol-tramadol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
Pharmacological aspects of successful long-term analgesia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2006 |
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Com | 2006 |
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A | 2006 |
[Management strategies for the treatment of non malignant chronic pain in the elderly].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Humans; Musculos | 2006 |
Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolinones.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxyg | 2007 |
Spinal cord injury.
Topics: Acetaminophen; Adult; Cognitive Behavioral Therapy; Colloids; Female; Humans; Pain; Pain Management; | 2006 |
[Clinical pharmacology of analgesics].
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain | 2007 |
[Non-opioid analgesics in cancer pain].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms; Pain | 2007 |
Tramadol for osteoarthritis: a systematic review and metaanalysis.
Topics: Acetaminophen; Analgesics, Opioid; Drug Therapy, Combination; Humans; Osteoarthritis; Pain; Pain Mea | 2007 |
A 60-year-old woman considering acupuncture for knee pain.
Topics: Acetaminophen; Acupuncture Therapy; Adrenal Cortex Hormones; Analgesics, Opioid; Anti-Inflammatory A | 2007 |
Pharmacologic management of adult cancer pain.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug | 2007 |
A new solution to pain control.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Emergency Service, Hospital; Humans; Infusions, Intravenous | 2007 |
Levator ani syndrome - a case study and literature review.
Topics: Acetaminophen; Adult; Anal Canal; Analgesics, Non-Narcotic; Anus Diseases; Baths; Diazepam; Family P | 2007 |
Management of pain in childhood.
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; | 2007 |
Using paracetamol before immunisation--does it work?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Evidence-Based Medicine; Fever; Humans; Pain; Practice Guid | 2007 |
Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration.
Topics: Acetaminophen; Adult; Age Factors; Analgesia; Analgesics, Non-Narcotic; Body Temperature; Child; Dos | 2008 |
Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs?
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclooxygenase 2 Inhi | 2007 |
Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics.
Topics: Acetaminophen; Analgesics; Animals; Humans; Nitrates; Pain | 2007 |
Recent advances in the pharmacological management of pain.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals | 2007 |
Pain medications in the locker room: to dispense or not.
Topics: Acetaminophen; Anesthetics; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Doping in Sp | 2007 |
Nonopioid analgesics.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxyg | 2007 |
COX-2 selective inhibitors in the treatment of osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl | 2008 |
Interventions for relieving the pain and discomfort of screening mammography.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Mammography; Pain; Patient Education as Top | 2008 |
Management of chronic musculoskeletal pain in the elderly: opinions on oral medication use.
Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipain; Chroni | 2008 |
Analgesic efficacy of dextropropoxyphene and dextropropoxyphene-containing combinations: a review.
Topics: Acetaminophen; Aminoacridines; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Chlorambucil | 1984 |
Chronic pain of childhood: a pharmacologic approach.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Anticon | 1984 |
Use of antipyretic analgesics in the pediatric patient.
Topics: Acetaminophen; Adolescent; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemic | 1983 |
[Paracetamol: overdose and hepatic lesions].
Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain | 1981 |
Acetaminophen toxicity: report of case and review of the literature.
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Blood Coagulation; Chemical and Drug Ind | 1995 |
Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Brain; | 1995 |
Acetylsalicylic acid and acetaminophen.
Topics: Acetaminophen; Adult; Aspirin; Child; Dental Care; Humans; Pain | 1994 |
[Paracetamol and other antipyretic analgesics: optimal doses in pediatrics].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Dose-Response Relationship, Drug; Dru | 1994 |
Pain management for the geriatric patient.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Narcotics; Pain; P | 1994 |
Should osteoarthritis be treated with nonsteroidal anti-inflammatory drugs?
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Drug Costs | 1993 |
[Effectiveness of fixed analgesic combinations exemplified by thomapyrin].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Germany; Humans; Pain | 1996 |
Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review.
Topics: Acetaminophen; Analgesia; Analgesics; Clinical Trials as Topic; Codeine; Dose-Response Relationship, | 1996 |
Paracetamol with and without codeine in acute pain: a quantitative systematic review.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, C | 1997 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
The management of chronic pain in patients with breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Society of Palliative Care Physicians. Canadian Association of Radiation Oncologist
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, L | 1998 |
Non-NSAID pharmacologic treatment options for the management of chronic pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1998 |
Co-proxamol or paracetamol for acute pain?
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Dextropropoxyphene; Drug Combinations; Human | 1998 |
Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine.
Topics: Acetaminophen; Drug Administration Schedule; Humans; Narcotics; Nausea; Neoplasms; Pain; Pain Manage | 1999 |
Non-opioid postoperative analgesia.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroida | 2000 |
Nonsteroidal anti-inflammatory drugs: overused or underused in osteoarthritis?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Prescriptions | 2001 |
The role of acetaminophen in the management of patients with osteoarthritis.
Topics: Acetaminophen; Activities of Daily Living; Age Distribution; Aged; Analgesics, Non-Narcotic; Anti-In | 2001 |
Pain management for neonatal circumcision.
Topics: Acetaminophen; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Hum | 2001 |
Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Clinical Trials as Topic; Fever; Humans; Liver; | 2000 |
Paracetamol efficacy and safety in children: the first 40 years.
Topics: Acetaminophen; Child; Fever; Humans; Nonprescription Drugs; Pain | 2000 |
Paracetamol: past, present, and future.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Pain | 2000 |
Update on pain management for advanced genitourinary cancer.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Humans; | 2001 |
Treatment of chronic pain in osteoarthritis: do opioids have a clinical role?
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Opioid-Related D | 2001 |
Chronic pain in the older patient: management strategies. 2.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antide | 2002 |
Pyoderma gangrenosum: a case study for pain management in dermatology nursing.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Joint Commission on A | 2000 |
Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesia; Cardiovascular System; Celecoxib; Clinical Trials as Topic; Cyclooxygenase | 2002 |
Effective use of analgesic drugs.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast | 1976 |
Acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; | 1977 |
Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity.
Topics: Acetaminophen; Aspirin; Body Temperature; Fever; Humans; Hypothalamus; Pain | 1978 |
Simple analgesics.
Topics: Acetaminophen; Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Drug Combi | 1975 |
Pain in neonatal circumcision.
Topics: Acetaminophen; Anesthesia, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Nerve Block; Pa | 1991 |
Pharmacologic management of pain in children and adolescents.
Topics: Acetaminophen; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 1989 |
Oral meptazinol--United Kingdom experience.
Topics: Acetaminophen; Adult; Aged; Azepines; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Met | 1985 |
345 trials available for acetaminophen and Ache
| Article | Year |
|---|---|
Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Asian People; Biotransformation; Chronic Disea | 2007 |
The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial.
Topics: Acetaminophen; Caffeine; Female; Humans; Low-Level Light Therapy; Male; Malocclusion, Angle Class I; | 2022 |
The experience of pain in real-time during medication abortion.
Topics: Abortion, Induced; Acetaminophen; Analgesics; Analgesics, Opioid; Female; Humans; Ibuprofen; Mifepri | 2022 |
The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media.
Topics: Acetaminophen; Acute Disease; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Earache; H | 2022 |
Effect of combined paracetamol and dexamethasone vs. paracetamol on postoperative nausea vomiting after cesarean section.
Topics: Acetaminophen; Antiemetics; Cesarean Section; Dexamethasone; Double-Blind Method; Female; Humans; Pa | 2022 |
Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study.
Topics: Acetaminophen; Administration, Inhalation; Adult; Ambulances; Analgesia; Analgesics; Anesthetics, In | 2022 |
Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions.
Topics: Acetaminophen; Administration, Intranasal; Analgesics, Opioid; Child; Child, Preschool; Communicable | 2022 |
The Effect of Thunder-Fire Moxibustion on Lumbar Disc Herniation: Study Protocol for a Randomized Controlled Trial.
Topics: Acetaminophen; Humans; Intervertebral Disc Displacement; Moxibustion; Pain; Quality of Life; Randomi | 2022 |
Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up.
Topics: Acetaminophen; Double-Blind Method; Female; Follow-Up Studies; Humans; Injections, Intra-Articular; | 2022 |
An international, open-label, randomised trial comparing a two-step approach versus the standard three-step approach of the WHO analgesic ladder in patients with cancer.
Topics: Acetaminophen; Analgesics, Opioid; Humans; Neoplasms; Pain; World Health Organization | 2022 |
Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Huma | 2022 |
Intravenous paracetamol for persistent pain after endoscopic mucosal resection discriminates patients at risk of adverse events and those who can be safely discharged.
Topics: Acetaminophen; Colonoscopy; Endoscopic Mucosal Resection; Female; Fentanyl; Humans; Pain; Patient Di | 2023 |
A Randomized Trial Comparing Intravenous Paracetamol, Topical Lidocaine, and Ice Application for Treatment of Pain Associated with Scorpion Stings: Some Concerns.
Topics: Acetaminophen; Humans; Ice; Lidocaine; Pain; Scorpion Stings | 2023 |
Acetaminophen changes Mu rhythm power related to pain empathy.
Topics: Acetaminophen; Electroencephalography; Emotions; Empathy; Humans; Pain | 2023 |
Effect of eye shield and ear muffs on pain intensity during venous blood sampling in premature infants: a clinical trial study.
Topics: Acetaminophen; Child; Humans; Infant, Newborn; Infant, Premature; Pain; Pain Measurement; Phlebotomy | 2023 |
Effectiveness and safety of prehospital analgesia including nalbuphine and paracetamol by paramedics: an observational study.
Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics; Butylscopolammonium Bromide; Emergency Medi | 2023 |
Lidocaine infusion has a 25% opioid-sparing effect on background pain after burns: A prospective, randomised, double-blind, controlled trial.
Topics: Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; A | 2020 |
Intravenous versus subcutaneous route pharmacokinetics of paracetamol (acetaminophen) in palliative care patients: study protocol for a randomized trial (ParaSCIVPallia).
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cross-Over Stud | 2020 |
Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial.
Topics: Abscess; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Double-Blind Method; | 2021 |
Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol.
Topics: Acetaminophen; Asthma; Child; Child, Preschool; Humans; Ibuprofen; Infant; Infant, Newborn; Multicen | 2020 |
Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Cross-Over Studies; Dementia; Disease Progression; Double-Bl | 2020 |
Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants.
Topics: Acetaminophen; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Vo | 2021 |
Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketoprofen; Pai | 2021 |
Randomized Controlled Trial Comparing Different Single Doses of Intravenous Paracetamol for Placement of Peripherally Inserted Central Catheters in Preterm Infants.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Catheterization, Central Venou | 2017 |
Correlation of Pain Reduction with fMRI BOLD Response in Osteoarthritis Patients Treated with Paracetamol: Randomized, Double-Blind, Crossover Clinical Efficacy Study.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain; Cross-Over Studies; Delayed-Action Preparation | 2018 |
Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Double-Blind Method; Fem | 2018 |
Intravenous versus oral paracetamol for acute pain in adults in the emergency department setting: a prospective, double-blind, double-dummy, randomised controlled trial.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Double-Blind Method; Emerge | 2018 |
Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Buprenorphine; Dementia; Depressive Disorder; Double-Blind M | 2018 |
Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial.
Topics: Acetaminophen; Administration, Oral; Analgesics; Double-Blind Method; Female; Humans; Ibuprofen; Inf | 2018 |
Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2018 |
Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dysmenorrhea; Female; H | 2018 |
Evaluating drugged driving: Effects of exemplar pain and anxiety medications.
Topics: Acetaminophen; Adult; Alprazolam; Anxiety; Cross-Over Studies; Double-Blind Method; Driving Under th | 2018 |
Double-blind placebo-controlled randomized clinical trial on the use of paracetamol for performing mammography.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Mammograp | 2018 |
Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Allergic Agents; Attention; Cognition; Cold Tem | 2018 |
Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial.
Topics: Acetaminophen; Adult; Amniocentesis; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; | 2018 |
[In process].
Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe | 2016 |
Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Elective Surgical Procedures; Fem | 2018 |
The Influence of Acetaminophen and Observational Conditioning on the Acquired Capability for Suicide.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Conditioning, Psychological; Female; Humans; Male; M | 2018 |
Evaluating the use of intra-articular injections as a treatment for painful hip osteoarthritis: a randomized, double-blind, multicenter, parallel-group study comparing a single 6-mL injection of hylan G-F 20 with saline.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Therapy, Com | 2019 |
Study of glutathione S-transferase levels in patients receiving intravenous paracetamol perioperatively: A randomized controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Double-Blind M | 2018 |
Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cross-Over Studies; Dementia; Depression; Double-Blin | 2018 |
N-acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double-blind controlled trial in healthy subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced | 2019 |
Pain relief after orthodontic archwire installation-a comparison between intervention with paracetamol and chewing gum: a randomized controlled trial.
Topics: Acetaminophen; Adolescent; Chewing Gum; Child; Female; Humans; Male; Orthodontic Wires; Pain; Pain M | 2019 |
A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Behavior Therapy; Double-Blind Method; Humans; Ibuprofen; P | 2019 |
Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Forgiveness; Humans; In | 2019 |
Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dulox | 2019 |
Effects of pre-emptive analgesia on efficacy of buccal infiltration during pulpotomy of mandibular primary molars: a double-blinded randomized controlled trial.
Topics: Acetaminophen; Analgesia; Child; Double-Blind Method; Humans; Ibuprofen; Molar; Pain; Pulpotomy; Too | 2019 |
Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Doub | 2019 |
The common pain of surrealism and death: acetaminophen reduces compensatory affirmation following meaning threats.
Topics: Acetaminophen; Adult; Death; Emotions; Fear; Female; Humans; Male; Motion Pictures; Pain; Placebo Ef | 2013 |
The response of agitated behavior to pain management in persons with dementia.
Topics: Acetaminophen; Aged, 80 and over; Analgesics; Buprenorphine; Delayed-Action Preparations; Dementia; | 2014 |
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu | 2013 |
Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dinoprostone; Double-Blind Method; Femal | 2014 |
Comparative study between 2 protocols for management of severe pain in patients with unresectable pancreatic cancer: one-year follow-up.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Autonomic Nerve Bloc | 2013 |
Are all placebo effects equal? Placebo pills, sham acupuncture, cue conditioning and their association.
Topics: Acetaminophen; Acupuncture Points; Acupuncture Therapy; Adult; Analgesics, Non-Narcotic; Analysis of | 2013 |
Take-Wait-Stop: a patient-centered strategy for writing PRN medication instructions.
Topics: Acetaminophen; Adult; Analgesics; Drug Labeling; Female; Health Literacy; Humans; Linear Models; Mal | 2013 |
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial.
Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Analgesics, | 2014 |
Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blin | 2014 |
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, and paracervical block application for pain relief during suction termination of first-trimester pregnancy.
Topics: Abortion, Induced; Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Anesthes | 2013 |
Efficacy of celecoxib in the treatment of joint pain caused by advanced haemophilic arthropathy in adult patients with haemophilia A.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase 2 In | 2014 |
Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Codeine; Double-Blind Method; Drug | 2014 |
A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aminolevulinic Acid; Analgesics, Non-Narcoti | 2014 |
A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesia, Epidural; Analgesics; Delayed-Action Preparat | 2014 |
Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Bone Nails; Child; Child, Preschool; | 2014 |
Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial.
Topics: Acetaminophen; Activities of Daily Living; Aged; Aged, 80 and over; Analgesics; Buprenorphine; Clini | 2014 |
Evaluation of pain in office hysteroscopy with prior analgesic medication: a prospective randomized study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; Female; H | 2014 |
A randomized, double-blind, placebo-controlled 12 week trial of acetaminophen extended release for the treatment of signs and symptoms of osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Delayed-Action Preparations; Double-Blind Meth | 2014 |
Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers.
Topics: Acetaminophen; Administration, Buccal; Adult; Analgesia; Cross-Over Studies; Dose-Response Relations | 2014 |
A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings.
Topics: Acetaminophen; Administration, Intravenous; Administration, Topical; Adolescent; Adult; Aged; Aged, | 2015 |
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2014 |
Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor.
Topics: Acetaminophen; Adult; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-B | 2015 |
The effect of intravenous paracetamol for the prevention of rocuronium injection pain.
Topics: Acetaminophen; Adult; Androstanols; Female; Humans; Injections, Intravenous; Male; Pain; Rocuronium | 2014 |
A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu | 2015 |
Improving patient knowledge and safe use of opioids: a randomized controlled trial.
Topics: Academic Medical Centers; Acetaminophen; Adolescent; Adult; Analgesics, Opioid; Double-Blind Method; | 2015 |
Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli.
Topics: Acetaminophen; Affect; Analgesics, Non-Narcotic; Arousal; Humans; Nonprescription Drugs; Pain; Photi | 2015 |
Efficacy of Single Dose Oral Paracetamol in Reducing Pain During Examination for Retinopathy of Prematurity: A Blinded Randomized Controlled Trial.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anesthetics, Local; Crying; Double-Bl | 2016 |
Comparative Analgesic Efficacy of Oxycodone/Acetaminophen vs Codeine/Acetaminophen for Short-Term Pain Management Following ED Discharge.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combinati | 2015 |
The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain; Cross-Over Studies; Double-Blind Method; Evok | 2015 |
Long-term use of minimal footwear on pain, self-reported function, analgesic intake, and joint loading in elderly women with knee osteoarthritis: A randomized controlled trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analysis of Variance; Disability E | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Efficacy and safety of low-dose SoluMatrix meloxicam in the treatment of osteoarthritis pain: a 12-week, phase 3 study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind | 2015 |
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesia; Curettage; Diclofenac; Female; Gynecologic Surgical Procedure | 2015 |
Intravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Biopsy; Demography; Double-Blin | 2015 |
Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinat | 2016 |
Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer.
Topics: Acetaminophen; Adult; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Carcinoma | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Empathy; Female; Humans; Male; Noise; | 2016 |
Efficacy of Plai Cream in Adult Patients with Muscle Strain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method | 2016 |
Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Female; Humans; Ibuprofen | 2016 |
Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels.
Topics: Acetaminophen; Calcium; Cell Membrane; Electrophysiological Phenomena; Female; HEK293 Cells; Humans; | 2016 |
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci | 2016 |
Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, | 2016 |
Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthriti | 2017 |
Comparison of iatrogenic pain between rotavirus vaccination before and after vaccine injection in 2-month-old infants.
Topics: Acetaminophen; Administration, Oral; Analgesics; Crying; Female; Humans; Infant; Injections; Logisti | 2017 |
Nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol do not affect 6-month mood-stabilizing treatment outcome among 482 patients with bipolar disorder.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2017 |
Premedication to reduce discomfort during screening mammography.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen | 2008 |
Atorvastatin may have no effect on acute phase reaction in children after intravenous bisphosphonate infusion.
Topics: Acetaminophen; Acute-Phase Reaction; Anticholesteremic Agents; Atorvastatin; Bone Density Conservati | 2009 |
Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind M | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, pa
Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Anal | 2009 |
Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 2010 |
Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2009 |
Oral administration of analgesia and anxiolysis for pain associated with bone marrow biopsy.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia, Local; | 2010 |
Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co | 2009 |
Randomized double-blind placebo controlled crossover study of acetaminophen, ibuprofen, acetaminophen/hydrocodone, and placebo for the relief of pain from a standard painful stimulus.
Topics: Acetaminophen; Acute Disease; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Effects of high dose orally administered paracetamol for heel prick pain in premature infants.
Topics: Acetaminophen; Administration, Oral; Chi-Square Distribution; Dose-Response Relationship, Drug; Doub | 2009 |
Influence of acetaminophen on performance during time trial cycling.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bicycling; Double-Blind Method; Exercise Test; Human | 2010 |
Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures.
Topics: Acetaminophen; Acute Disease; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analysis of Var | 2009 |
Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements | 2009 |
...And what's best for fracture pain in children?
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Codeine; Drug Combin | 2009 |
Lack of benefit from paracetamol (acetaminophen) for palliative cancer patients requiring high-dose strong opioids: a randomized, double-blind, placebo-controlled, crossover trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Studies; Double | 2010 |
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis | 2010 |
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis | 2010 |
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis | 2010 |
A walking model to assess the onset of analgesia in osteoarthritis knee pain.
Topics: Acetaminophen; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations; Exercis | 2010 |
Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol representing three different groups of analgesics for pain control in extracorporeal shockwave lithotripsy.
Topics: Acetaminophen; Adult; Analgesics; Demography; Female; Humans; Lithotripsy; Male; Middle Aged; Pain; | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Double-Blind Method; Dr | 2009 |
Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Female; | 2011 |
Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co | 2010 |
Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Double-Blind Method | 2010 |
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Diseas | 2010 |
Acetaminophen plus codeine compared to ketorolac in polytrauma patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, | 2010 |
Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy.
Topics: Acetaminophen; Adult; Aged; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Diabetes Mellit | 2010 |
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl | 2010 |
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl | 2010 |
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl | 2010 |
The effect of cold application in combination with standard analgesic administration on pain and anxiety during chest tube removal: a single-blinded, randomized, double-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anxiety; Chest Tubes; Cl | 2010 |
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum | 2011 |
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum | 2011 |
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum | 2011 |
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum | 2011 |
Pain management in young children undergoing diagnostic tympanocentesis.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Biopsy, Fine-Needle; Chi | 2011 |
Safety of multiple-dose intravenous acetaminophen in adult inpatients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Fever; Humans; Injections, Intravenous; Pain; Prospe | 2010 |
Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model.
Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Codei | 2011 |
Effects of analgesics on orthodontic pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Bone Neopla | 2012 |
Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2011 |
Epidemiological data, efficacy and safety of a paracetamol-tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practice.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Female; Humans | 2011 |
Tropisetron blocks analgesic action of acetaminophen: a human pain model study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents; Cross-Over | 2011 |
Randomised controlled trial comparing oral and intravenous paracetamol (acetaminophen) plasma levels when given as preoperative analgesia.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Female; Huma | 2011 |
Medical expulsive therapy using alfuzosin for patient presenting with ureteral stone less than 10mm: a prospective randomized controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, | 2011 |
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over | 2011 |
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respo | 2011 |
The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID).
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; | 2012 |
A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Anti- | 2011 |
Paracetamol and opioid pathways: a pilot randomized clinical trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cross-Over Studies; Double-Bli | 2013 |
Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Double-Blind Method; Extraction, Ob | 2013 |
Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum.
Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Delivery, Obstetric; Do | 2013 |
The effect of paracetamol and tropisetron on pain: experimental studies and a review of published data.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cross-Over Studies; Double-Blind Method; Dr | 2013 |
A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice.
Topics: Abdomen; Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2012 |
A novel paracetamol 1,000 mg sustained release formulation vs conventional paracetamol 500 mg formulation in patients with fever and pain: a randomized noninferiority trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antipyretics; Delayed-Action Prepa | 2013 |
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; | 2002 |
Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over | 2002 |
Changes in size of periarthritis calcifications in patients with painful shoulder treated with injectable disodium-clodronate.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Calcinosis; Clodro | 2002 |
Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Co | 2002 |
Prospective study on incidence and functional impact of transient neurologic symptoms associated with 1% versus 5% hyperbaric lidocaine in short urologic procedures.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, | 2003 |
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug | 2003 |
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug | 2003 |
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug | 2003 |
Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug | 2003 |
Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Male | 2000 |
Intravenous corticosteroids to reduce gemtuzumab ozogamicin infusion reactions.
Topics: Acetaminophen; Adult; Aminoglycosides; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflamm | 2003 |
Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol.
Topics: Acetaminophen; Administration, Oral; Aged; Double-Blind Method; Female; Humans; Interleukin-6; Male; | 2003 |
Is there an additive analgesic effect of paracetamol at step 3? A double-blind randomized controlled study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Delayed | 2003 |
Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; | 2004 |
Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Biological Availability; Chemistry | 2004 |
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2004 |
Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life.
Topics: Acetaminophen; Activities of Daily Living; Administration, Cutaneous; Aged; Aged, 80 and over; Analg | 2004 |
[Treatment of functional signs of acute maxillary rhinosinusitis in adults. Efficacy and tolerance of administration of oral prednisone for 3 days].
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-In | 2004 |
Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics; Dose-Response Relationship, Drug; Doubl | 2004 |
A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cross-Over Studies; Dementia; Doub | 2004 |
Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthenia; Chills; Double-Blind Method; Drug Administ | 2004 |
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu | 2004 |
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu | 2004 |
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu | 2004 |
Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: a randomized, double-blind, placebo-controlled cross-over trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Stu | 2004 |
Continuous low-level heat wrap therapy is effective for treating wrist pain.
Topics: Acetaminophen; Activities of Daily Living; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bandag | 2004 |
Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Area Under | 2004 |
Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Bli | 2004 |
A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis.
Topics: Acetaminophen; Adjuvants, Immunologic; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, No | 2004 |
[Results of an open prospective controlled randomized comparative trial of efficacy and tolerance of sublingual tablets flurbiprofen (strepfen) and paracetamol in patients with throat pain in acute infectious-inflammatory diseases of the upper respiratory
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Hypersensitivity; Flurbiprofen; Humans; Pain; Prospect | 2004 |
A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Aspirin; Female; Humans; Ibuprofen; Male; Middle | 2005 |
[Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Female; Flurbiprofen; Humans; Male | 2005 |
The analgesic effect of etoricoxib relative to that of cetaminophen analgesics: a randomized, controlled single-dose study in acute dental impaction pain.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varia | 2005 |
Paravertebral block with ropivacaine 0.5% versus systemic analgesia for pain relief after thoracotomy.
Topics: Acetaminophen; Adult; Aged; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, | 2005 |
Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response | 2005 |
Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2005 |
Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind M | 2005 |
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans | 2005 |
Paediatric cancer pain management using the WHO analgesic ladder--results of a prospective analysis from 2265 treatment days during a quality improvement study.
Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics; Analgesics, Opioid; Antineoplastic Agents; | 2006 |
Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Double-Blind M | 2006 |
Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Huma | 2006 |
Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee.
Topics: Acetaminophen; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Therapy, Combination; Humans | 2006 |
Erythromycin promotes gastric emptying during acute pain in volunteers.
Topics: Acetaminophen; Acute Disease; Adult; Breath Tests; Caprylates; Cold Temperature; Cross-Over Studies; | 2006 |
Pre-surgical child behavior ratings and pain management after two different techniques of tonsil surgery.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Anti-Inflammato | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial.
Topics: Acetaminophen; Administration, Oral; Aged; Analgesics; Anesthetics, Local; Biopsy, Needle; Double-Bl | 2006 |
A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Adrenergic Uptake Inhibitors; Aged; Analgesics, Non-Narcotic; Diabetic Neuropathies; | 2006 |
Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Analgesia; Analgesics, Non-Narcotic; Doub | 2006 |
Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection.
Topics: Acetaminophen; Adult; Double-Blind Method; Drug Therapy, Combination; Ephedrine; Female; Humans; Mal | 2006 |
Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Me | 2006 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Area Under Curve; Caffeine; Central Nerv | 2007 |
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspart | 2007 |
Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents, Non-S | 2007 |
Effects of paracetamol combined with dextromethorphan in human experimental muscle and skin pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Drug Therapy, Combi | 2007 |
Supra-additive effects of tramadol and acetaminophen in a human pain model.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Computer Simulation; Cross-Over | 2008 |
A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain.
Topics: Acetaminophen; Adult; Aged; Analgesics; Double-Blind Method; Drug Administration Schedule; Drug Comb | 2007 |
Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Anesthetics, Local; Double | 2008 |
Analgesic effect of paracetamol on cancer related pain in concurrent strong opioid therapy. A prospective clinical study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Administr | 2008 |
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].
Topics: Acetaminophen; Double-Blind Method; Female; Glucosamine; Humans; Insulin-Like Growth Factor I; Male; | 2007 |
Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study.
Topics: Acetaminophen; Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, No | 2007 |
The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroi | 2007 |
Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study.
Topics: Abortion, Induced; Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Age | 2009 |
A comparison of aspirin and paracetamol.
Topics: Acetaminophen; Adult; Aspirin; Humans; Male; Nursing Service, Hospital; Orthopedics; Pain; Placebos | 1967 |
Analgesia following oral surgery: a comparative study of Solpadeine and a soluble form of dextropropoxyphene napsylate and paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Codeine; Dextropropoxyphene; Drug Combinations; Female; | 1983 |
Analgesic efficacy of dextropropoxyphene and dextropropoxyphene-containing combinations: a review.
Topics: Acetaminophen; Aminoacridines; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Chlorambucil | 1984 |
A double-blind comparison in general practice of a combination tablet containing orphenadrine citrate and paracetamol ('Norgesic') with paracetamol alone.
Topics: Acetaminophen; Adolescent; Adult; Aged; Back Pain; Bone Diseases; Double-Blind Method; Drug Combinat | 1983 |
[Evaluation of the analgesic effect of UP 341-01 in patients presenting with acute pain in ORL].
Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injection | 1983 |
[Effect of orphenadrine/paracetamol combination tablets (Norgesic) on myalgia. A double-blind comparative study using a placebo in general practice].
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Huma | 1983 |
Report of a double-blind crossover study to compare flurbiprofen with paracetamol in the treatment of primary dysmenorrhoea.
Topics: Acetaminophen; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Hu | 1983 |
Transcutaneous electrical nerve stimulation in osteoarthrosis: a therapeutic alternative?
Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Electric Stimulation Ther | 1984 |
Caffeine as an analgesic adjuvant.
Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou | 1984 |
Distalgesic; safety and efficacy. Efficacy: UK experience.
Topics: Acetaminophen; Apazone; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Drug Combin | 1984 |
Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; I | 1984 |
Clinical trial of flupirtine maleate in patients with migraine.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aminopyridines; Clinical Trials as Top | 1984 |
A comparison between meptazinol and dextropropoxyphene plus paracetamol in elderly patients with musculoskeletal pains.
Topics: Acetaminophen; Aged; Azepines; Bone Diseases; Clinical Trials as Topic; Dextropropoxyphene; Drug Com | 1984 |
A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea.
Topics: Acetaminophen; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Dysmenorrhe | 1983 |
A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev | 1984 |
Effect of a combination of orphenadrine/paracetamol tablets ('Norgesic') on myalgia: a double-blind comparison with placebo in general practice.
Topics: Acetaminophen; Adolescent; Adult; Aged; Double-Blind Method; Drug Combinations; Female; Humans; Male | 1983 |
Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Combinations; Humans; Metoclopr | 1983 |
Diflunisal. A new oral analgesic with an unusually long duration of action.
Topics: Acetaminophen; Administration, Oral; Clinical Trials as Topic; Codeine; Delayed-Action Preparations; | 1982 |
A comparison of three ways of measuring pain.
Topics: Acetaminophen; Aged; Apazone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomet | 1982 |
[Analgesic, antipyretic and anti-rheumatic activity of 2 preparations evaluated in a multicenter clinical trial].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Clinical Trials | 1982 |
Visual analogue scale and the analysis of analgesic action.
Topics: Acetaminophen; Adult; Analgesics; Codeine; Double-Blind Method; Drug Combinations; Humans; Male; Pai | 1983 |
Comparative analgesic efficacies of aspirin and acetaminophen.
Topics: Acetaminophen; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Inflamma | 1981 |
A double-blind comparison of meptazinol versus distalgesic in acute of chronic pain presenting to the general practitioner.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Azepines; Chronic Disease; Dextropropoxyphene | 1982 |
A double-blind comparison of meptazinol versus paracetamol and placebo in acute and chronic painful conditions presented to the general practitioner.
Topics: Acetaminophen; Acute Disease; Adult; Azepines; Chronic Disease; Double-Blind Method; Female; Humans; | 1982 |
Methodological considerations in the evaluation of analgesic combinations: acetaminophen (paracetamol) and hydrocodone in postpartum pain.
Topics: Acetaminophen; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Hu | 1980 |
Comparative study of mefenamic acid and dextropropoxyphene plus paracetamol in an accident and emergency department.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Dextropropoxyphene; Double-Blind Method; Drug The | 1980 |
Intravenous regional anesthesia using lidocaine and ketorolac.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla | 1995 |
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans | 1994 |
Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug | 1994 |
n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia; Capsules; Diclofenac; Double-Blind Method; | 1994 |
Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Clonixin; Double-Blind Method; Female; Humans; L | 1993 |
Acetaminophen analgesia in neonatal circumcision: the effect on pain.
Topics: Acetaminophen; Circumcision, Male; Double-Blind Method; Humans; Infant, Newborn; Intraoperative Peri | 1994 |
Effects of acetaminophen on adverse effects of influenza vaccination in health care workers.
Topics: Acetaminophen; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Influenza Vacc | 1993 |
Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients.
Topics: Acetaminophen; Activities of Daily Living; Aged; Aged, 80 and over; Double-Blind Method; Drug Therap | 1993 |
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In | 1993 |
A placebo-controlled model for assaying systemic analgesics in children.
Topics: Acetaminophen; Child; Child, Preschool; Double-Blind Method; Female; Humans; Ibuprofen; Male; Pain; | 1993 |
Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Codeine; Cros | 1995 |
A prospective comparison of transnasal butorphanol and acetaminophen with codeine for the relief of acute musculoskeletal pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Butorphanol; Humans; Musculoskeletal Di | 1997 |
Analgesia following arthroscopy--a comparison of intra-articular morphine, pethidine and fentanyl.
Topics: Acetaminophen; Adult; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; | 1997 |
The efficacy of tepid sponge bathing to reduce fever in young children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Baths; Body Temperature; Child; Child, Preschool; Combined | 1997 |
Dose-related effects of oral acetaminophen on cold-induced pain: a double-blind, randomized, placebo-controlled trial.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cold Tem | 1998 |
Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 1998 |
Basal hormone levels in women who use acetaminophen for menstrual pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Basal Metabolism; Estradiol; Female; Fertilization i | 1998 |
Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcoti | 1998 |
Randomised controlled trial of paracetamol for heel prick pain in neonates.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Blood Specimen Collection; Female; Hu | 1998 |
Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In | 1999 |
Multiple-dose pharmacokinetics of rectally administered acetaminophen in term infants.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Chromatography, High Pressure Liqui | 1999 |
Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Analgesia; Analgesics, Non-Narcotic; Double-Blind Method; Dry Sock | 2000 |
Combined analgesia and local anesthesia to minimize pain during circumcision.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Anesthesia, Local; Anesthe | 2000 |
Randomized double blind trial of an ayurvedic plant derived formulation for treatment of rheumatoid arthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; | 2000 |
Managing delayed-onset muscle soreness: lack of effect of selected oral systemic analgesics.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Codeine; Double- | 2000 |
Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain.
Topics: Acetaminophen; Adult; Aged; Analgesics; Chronic Disease; Codeine; Double-Blind Method; Drug Therapy, | 2000 |
A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arm Injuries; Diclofenac; Emergency Se | 2000 |
Effects of rectally administered paracetamol on infants delivered by vacuum extraction.
Topics: Acetaminophen; Administration, Rectal; Double-Blind Method; Facial Expression; Female; Humans; Infan | 2001 |
Disodium clodronate in painful nonresponsive periarthropathy of the hip.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Bone Resorption; Bursitis; Clodronic Acid; Drug Thera | 2000 |
Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroid | 2001 |
[Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female; | 2001 |
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics; Analgesics, Opioid; Codeine; Double-Bl | 2001 |
Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics; Codeine; Delivery, Obstetric; Double-Blind Method; Episiotomy; Fem | 2001 |
Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Butylscopolammonium Bromide; Clonixin; Cross-Over St | 2001 |
Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Respon | 2002 |
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri | 1976 |
[New preparation with antalgic sedative and anxiolytic activity in manifestations of interest to internal medicine. Double-blind controlled clinical study].
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Clor | 1977 |
Acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; | 1977 |
Mefenamic acid and dextropropoxyphene with paracetamol as analgesics in the accident department.
Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug | 1977 |
Effect of acetylsalicylic acid, paracetamol, and placebo on pain and blood loss in dysmenorrhoeic women.
Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; | 1978 |
Evaluation of acetaminophen, propoxyphene, and their combination in office practice.
Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Dextropropoxyphene; Drug Combinations; Family | 1979 |
Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain. A double blind study.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Electric Stimulation; Fem | 1979 |
[Treatment of distortions and non-traumatic conditions of pain and swelling. Double-blind trial with an analgetic and detumescent drug combination].
Topics: Acetaminophen; Adult; Double-Blind Method; Drug Combinations; Drug Synergism; Edema; Humans; Joint D | 1978 |
A controlled study of diflunisal in sprains and strains.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics; Biphenyl Compounds; Dextropropoxyph | 1978 |
Drug therapy. Acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Body Temperature; Chemical and Drug Induced Liver Injury; | 1976 |
Azapropazone compared with indomethacin in the treatment of rheumatoid arthritis.
Topics: Acetaminophen; Adult; Aged; Apazone; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Hand; | 1976 |
The efficacy of Percogesic in relief of musculoskeletal pain associated with anxiety.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Drug Combinations; Female | 1976 |
A clinical Trial of Tofranil in osteo-arthritis.
Topics: Acetaminophen; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Imipram | 1976 |
A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice.
Topics: Acetaminophen; Analgesics; Aspirin; Clinical Trials as Topic; Female; Humans; Hydrocodone; Male; ort | 1976 |
Acetaminophen extra strength capsules versus propoxphene compound-65 versus placebo: a double-blind study of effectiveness and safety.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Capsules; Clinical Trials as Topic; Dextropropo | 1975 |
Paracetamol/codeine in relieving pain following removal of impacted mandibular third molars.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Codeine; Drug Therapy, Combination; Edema; Female; Humans | 1975 |
A comparative study of Parafon Forte tablets and soma compound in the treatment of painful skeletal muscle conditions.
Topics: Acetaminophen; Adolescent; Adult; Benzoxazoles; Carisoprodol; Chlorzoxazone; Drug Combinations; Fema | 1976 |
Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Digestive System; Female; F | 1975 |
[Comparative evaluation of the therapeutic efficiency of flurbiprofene in rheumatoid polyarthritis].
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Biphenyl Compounds; Chemical Phenomena; Chemistry; Cl | 1975 |
Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity.
Topics: Acetaminophen; Adult; Antipyrine; Double-Blind Method; Electroencephalography; Evoked Potentials, Au | 1992 |
What do women want during medical abortion?
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Administration, Oral; Adolesce | 1992 |
The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chronic Disease; Codeine; Delayed-Action Preparations | 1992 |
Evaluation of the analgesic efficacy of a combination of naproxen and paracetamol versus dipyrone on the tourniquet test in healthy volunteers.
Topics: Acetaminophen; Adult; Autonomic Nervous System; Dipyrone; Double-Blind Method; Drug Combinations; El | 1992 |
Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol. Double blind, placebo-controlled evaluation using painful laser stimulation.
Topics: Acetaminophen; Adult; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Lasers; Male | 1992 |
Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories.
Topics: Acetaminophen; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschoo | 1992 |
Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol.
Topics: Acetaminophen; Double-Blind Method; Episiotomy; Female; Humans; Naproxen; Norway; Pain; Pain Measure | 1991 |
Hydrocodone versus codeine in acute musculoskeletal pain.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Codeine; Double-Blind Method; Drug Combinatio | 1991 |
Randomized, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children.
Topics: Acetaminophen; Administration, Oral; Child; Deglutition; Double-Blind Method; Drug Tolerance; Female | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
A comparison of the hypoalgesic effect of paracetamol in slow-release and plain tablets on laser-induced pain.
Topics: Acetaminophen; Adult; Analgesics; Delayed-Action Preparations; Double-Blind Method; Female; Humans; | 1991 |
Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine--a quantitative evaluation by laser induced pain.
Topics: Acetaminophen; Adult; Analgesia; Brain; Codeine; Double-Blind Method; Humans; Lasers; Membrane Poten | 1991 |
Acetaminophen as a pain enhancer during voluntary interruption of pregnancy with mifepristone and sulprostone.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Dinoprostone; Double-Blind Met | 1990 |
A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate.
Topics: Acetaminophen; Administration, Topical; Adult; Ankle; Ankle Injuries; Anti-Inflammatory Agents, Non- | 1990 |
Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study.
Topics: Acetaminophen; Aged; Chronic Disease; Codeine; Double-Blind Method; Drug Combinations; Hip Joint; Hu | 1990 |
Evaluation of analgesic agents in recurring headache compared with other clinical pain models.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Codeine; Data Interpretation, Statistical; Doubl | 1990 |
Analgesic efficacy of acetaminophen sustained release.
Topics: Acetaminophen; Adult; Ambulatory Care; Analgesia; Delayed-Action Preparations; Double-Blind Method; | 1990 |
The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain.
Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Bone Neoplasms; Chronic Disease; Codeine; Double-B | 1988 |
Joint pain and quality of life; results of a randomised trial.
Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Dextropropoxyphen | 1989 |
Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Arthroscopy; Clinical Trials as Topic; Dextropropoxyphene; Double- | 1987 |
Comparative study of high bio-availability glaphenine and paracetamol in cervical and lumbar arthrosis.
Topics: Acetaminophen; Arthritis; Biological Availability; Double-Blind Method; Glafenine; Humans; Movement; | 1987 |
A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Double-Blind Method; Glafenine; Hip Joint; Humans; Kn | 1988 |
Flurbiprofen for the treatment of soft tissue trauma.
Topics: Acetaminophen; Aspirin; Back Pain; Flurbiprofen; Humans; Knee; Leg Injuries; Ligaments, Articular; P | 1986 |
Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine.
Topics: Acetaminophen; Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Codeine; Diflunisal; Drug | 1986 |
Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion.
Topics: Acetaminophen; Adult; Back Pain; Clinical Trials as Topic; Colic; Electrocoagulation; Female; Humans | 1986 |
The pain intensity at analgesic intake, and the efficacy of diflunisal in single doses and effervescent acetaminophen in single and repeated doses.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Pain; Salicylates; | 1988 |
Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain.
Topics: Acetaminophen; Adult; Ankle Injuries; Codeine; Diflunisal; Drug Combinations; Edema; Female; Humans; | 1986 |
Sore throat pain in the evaluation of mild analgesics.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Double-Blind Method; Drug Evaluation; Fem | 1988 |
Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine.
Topics: Acetaminophen; Body Temperature; Clinical Trials as Topic; Diphtheria Toxoid; Diphtheria-Tetanus-Per | 1987 |
[Combined analgesics in myalgia of the neck. A double-blind comparison of paracetamol and orphenadrine (Norgesic) and paracetamol and codeine (Paralgin forte) in general practice].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double | 1986 |
Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains.
Topics: Acetaminophen; Adolescent; Adult; Athletic Injuries; Clinical Trials as Topic; Codeine; Diflunisal; | 1986 |
Comparison of the analgesic effect of a corticosteroid and paracetamol in patients with pain after oral surgery.
Topics: Acetaminophen; Adolescent; Adrenal Cortex Hormones; Adult; Analgesics; Clinical Trials as Topic; Dou | 1986 |
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele | 1987 |
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele | 1987 |
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele | 1987 |
Transcutaneous electrical nerve stimulation versus oral analgesic: a randomized double-blind controlled study in acute traumatic pain.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Ele | 1987 |
Efficacy of diflunisal versus acetaminophen with codeine in controlling mild to moderate pain after arthroscopy.
Topics: Acetaminophen; Adolescent; Adult; Arthroscopy; Codeine; Diflunisal; Drug Combinations; Drug Evaluati | 1986 |
Double-blind comparison of ketoprofen and placebo in the treatment of sprains and strains.
Topics: Acetaminophen; Adolescent; Adult; Cryotherapy; Double-Blind Method; Female; Humans; Immobilization; | 1986 |
Oral meptazinol--United Kingdom experience.
Topics: Acetaminophen; Adult; Aged; Azepines; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Met | 1985 |
A comparative study of Propain and a dextropropoxyphene/paracetamol combination analgesic.
Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Dextropropoxyphene; Diphenhydramine; Drug | 1985 |
Effect of an analgesic drug (paralgin forte) upon laboratory pain under different cognitive manipulations: an experimental study.
Topics: Acetaminophen; Adult; Analgesics; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; M | 1985 |
Use of subjective responses to evaluate efficacy of mild analgesic-sedative combinations.
Topics: Acetaminophen; Analgesics; Chloral Hydrate; Clinical Trials as Topic; Drug Therapy, Combination; Fem | 1974 |
A double-blind comparative trial of 'parazolidin' and paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Elbow Joint; Female; Fi | 1969 |
Parazolidin: a new compound analgesic preparation.
Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Muscular Di | 1966 |
Simple analgesics for arthritis.
Topics: Acetaminophen; Alkenes; Analgesics; Arthritis, Rheumatoid; Aspirin; Codeine; Color; Dextropropoxyphe | 1974 |
Fenoprofen in the treatment of osteoarthrosis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Humans; Osteoarthritis; Pain; Phenyl Ethers; Phenylbutazone | 1974 |
Acetaminophen versus propoxyphene hydrochloride for relief of pain in episiotomy patients.
Topics: Acetaminophen; Adolescent; Adult; Clinical Trials as Topic; Dextropropoxyphene; Episiotomy; Female; | 1973 |
[EMA 3--a phenacetin-free combination with analgesic action].
Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as | 1973 |
Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzoates; | 1973 |
Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Body Temperature; Clinical Trials as Topic; Deafness; | 1974 |
Double-blind cross-over comparison of indomethacin, flurbiprofen, and placebo in ankylosing spondylitis.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents; Biphenyl Compounds; Blood Sedimentation; Clinical Tr | 1974 |
Mild analgesics evaluated with the "Submaximum Effort Tourniquet Technique". II. The influence of a tranquilizer on their effect.
Topics: Acetaminophen; Adult; Alkenes; Analgesics; Analysis of Variance; Anthracenes; Clinical Trials as Top | 1974 |
A double-blind evaluation of Parafon Forte in the treatment of musculo-skeletal back conditions.
Topics: Acetaminophen; Adolescent; Adult; Back; Benzoxazoles; Bone Diseases; Chlorzoxazone; Clinical Trials | 1972 |
Thrombosis in sickle-cell pain crises? Controlled trial of ancrod (Arvin) in young adults.
Topics: Acetaminophen; Adolescent; Adult; Ampicillin; Anemia, Sickle Cell; Child; Chloroquine; Female; Fetal | 1973 |
Perceptual style and pain tolerance. II. The influence of an anxiolytic agent.
Topics: Acetaminophen; Adaptation, Physiological; Adaptation, Psychological; Adult; Anthracenes; Anxiety; Fe | 1973 |
Dialog. A double-blind clinical study of dialog, darvon and a placebo in the management of postoperative dental pain.
Topics: Acetaminophen; Barbiturates; Clinical Trials as Topic; Pain; Postoperative Care; Surgery, Oral; Toot | 1967 |
[Clinical observation on the analgesic effect of the acetaminophen-phenylbutazone combination in angiology].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Arteriosclerosis; Arteriovenous Fistula; Blood V | 1968 |
Dialog in treatment of dental pain.
Topics: Acetaminophen; Adult; Barbiturates; Clinical Trials as Topic; Female; Humans; Male; Pain; Postoperat | 1969 |
Evaluation of mefenamic acid and flufenamic acid in clinical pain.
Topics: Acetaminophen; Anti-Inflammatory Agents; Clinical Trials as Topic; Flufenamic Acid; Fluorine; Humans | 1966 |
Mefenamic acid as an analgesic.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Drug Syn | 1970 |
Method, design, and analysis of a comparative study of analgetics.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P | 1970 |
A comparison of analgesic therapies for the relief of acute otalgia.
Topics: Acetaminophen; Choline; Clinical Trials as Topic; Ear Diseases; Humans; Pain; Salicylates | 1970 |
Method, design, and analysis of a comparative study of analgetics.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P | 1970 |
[Experiences with an analgesic in accident surgery].
Topics: Acetaminophen; Clinical Trials as Topic; Humans; Pain; Wounds and Injuries | 1965 |
A clinical comparison of Panadeine Co., soluble codeine co., soluble aspirin in the relief of pain.
Topics: Acetaminophen; Aspirin; Clinical Trials as Topic; Codeine; Humans; Pain | 1966 |
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei | 1970 |
576 other studies available for acetaminophen and Ache
| Article | Year |
|---|---|
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Fever; Humans; Intramolecular Oxi | 2008 |
Antinociceptive properties of caffeic acid derivatives in mice.
Topics: Analgesics; Animals; Caffeic Acids; Mice; Molecular Structure; Pain; Structure-Activity Relationship | 2009 |
Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Dose-Response Relationship, Drug; | 2014 |
Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity.
Topics: Acetaminophen; Amidohydrolases; Aminophenols; Analgesics; Animals; Antipyretics; Arachidonic Acids; | 2021 |
[Pain and dementia: what to consider?]
Topics: Acetaminophen; Cognition; Dementia; Humans; Pain; Pain Management | 2021 |
Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2023 |
Pharmacological Pain Treatment in 2012 and 2017 Among Older People with Major Neurocognitive Disorder.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2021 |
Single-Dose Oral NSAIDs and Acetaminophen for Perineal Pain in the Early Postpartum Period.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Pa | 2021 |
Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain.
Topics: Acetaminophen; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Meloxicam; Mice; Pain; R | 2022 |
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr | 2022 |
Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers.
Topics: Acetaminophen; Administration, Oral; Adult; Biological Availability; Body Composition; Body Weight; | 2022 |
Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Humans; Pain; Retrospective Studies | 2022 |
Child Emotion Regulation Capacity Moderates the Association Between Parent Behaviors and Child Distress During Pediatric Venipuncture.
Topics: Acetaminophen; Adult; Child; Emotional Regulation; Humans; Needles; Pain; Parents; Phlebotomy | 2023 |
Use of Intravenous Paracetamol Preoperatively Favors Lower Risk of Delirium and Functional Recovery in Elderly Patients with Hip Fracture: A Propensity Score-Matched Analysis.
Topics: Acetaminophen; Aged; Delirium; Hip Fractures; Humans; Pain; Propensity Score; Retrospective Studies | 2022 |
Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study.
Topics: Acetaminophen; Caffeine; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nonprescri | 2022 |
Immediate full weight bearing after pelvic percutaneous fixation by screw for simple acetabular and pelvic ring fractures in patients older than sixty five years.
Topics: Acetaminophen; Bone Screws; Fractures, Bone; Humans; Morphine; Pain; Retrospective Studies; Weight-B | 2022 |
Patient satisfaction after distal upper limb surgery under WALANT versus axillary block: A propensity-matched comparative cohort study.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Cohort Studies; Humans; Ketoprofen; Pain; Patient Sat | 2022 |
Translator use not associated with longer time to pain medication in initial evaluation of low-severity geriatric trauma.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Female; Humans; Lidocaine; Male; Pain; Retrospective Studie | 2022 |
Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort.
Topics: Acetaminophen; Analgesics, Opioid; Bupivacaine; Humans; Ketorolac; Male; Pain; Prostatectomy; Roboti | 2022 |
A paediatric pain assessment and management survey at Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa.
Topics: Acetaminophen; Child; Cross-Sectional Studies; Female; Hospitals; Humans; Infant; Infant, Newborn; M | 2022 |
Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Feeding Beh | 2022 |
Pediatric Hip Disease Increases the Risk for Opioid Use in Adulthood: Long-term Burden of Pain and Depression.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents; Antidepressive Agent | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Formation of Larger Molecular Weight Disinfection Byproducts from Acetaminophen in Chlorine Disinfection.
Topics: Acetaminophen; Chlorine; COVID-19; Disinfectants; Disinfection; Drinking Water; Halogenation; Humans | 2022 |
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri | 2023 |
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri | 2023 |
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri | 2023 |
Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Humans; Opioid-Related Disorders; Pain; Prescri | 2023 |
Prevalence and persistent prescription of analgesic drugs in persons admitted with dementia to a nursing home - A longitudinal study.
Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Analgesics; Analgesics, Opioid; Dement | 2022 |
Modulation of inflammatory mediators involved in the antinociceptive and anti-inflammatory effects of a new thioamide derivative: thiocyanoacetamide.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Inflammation Mediators; Pain; Rats | 2023 |
Use of analgesics in Denmark: A national survey.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Denmark; Drug-Related Side Effects and Adverse Reactio | 2023 |
A Descriptive Study of Treatment of Pain in Acute Care for Patients Living With Dementia.
Topics: Acetaminophen; Dementia; Female; Humans; Pain; Pain Management; Tramadol | 2023 |
Impact of dexmedetomidine in conjunction with a weaning protocol on post-surgical opioid use in a neonatal intensive care unit.
Topics: Acetaminophen; Analgesics, Opioid; Clonidine; Dexmedetomidine; Humans; Infant, Newborn; Intensive Ca | 2023 |
Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age | 2023 |
Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Bilirubin; Cohort Studies; Humans; In | 2023 |
MANAGING ARTHRITIS PAIN: MEDICATIONS AND LIFESTYLE CHANGES.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Life Style; Osteoarthritis, Knee; Pa | 2023 |
The Perioperative Pain Management Bundle is Feasible: Findings From the PAIN OUT Registry.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Pain; Pain Management; Registries | 2023 |
Mpox Pain Management with Topical Agents: A Case Series.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Lidocaine; Mpox (monkeypox); Pain; P | 2023 |
Fixing a Broken Heart Opens the Door to Developing K
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics; Humans; Pain | 2023 |
Blot Clot Risk Higher When Pain Relievers Used With Hormonal Contraception.
Topics: Acetaminophen; Analgesics; Contraception; Contraceptives, Oral, Hormonal; Female; Hormonal Contracep | 2023 |
[Clinical characteristics and therapeutic effectiveness of post craniotomy cervicogenic headache].
Topics: Acetaminophen; Craniotomy; Humans; Oxycodone; Pain; Post-Traumatic Headache; Retrospective Studies | 2023 |
Pain and quality of life in nursing home residents with dementia after admission - a longitudinal study.
Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Analgesics, Opioid; Dementia; Female; | 2023 |
Safety and efficacy of non-standard posology of paracetamol to manage pain in pediatric patients.
Topics: Acetaminophen; Child; Humans; Pain | 2023 |
Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study.
Topics: Acetaminophen; Codeine; Humans; Machine Learning; Pain; Social Media; Tramadol | 2023 |
Studies on solubility measurement of codeine phosphate (pain reliever drug) in supercritical carbon dioxide and modeling.
Topics: Acetaminophen; Carbon Dioxide; Codeine; Humans; Pain; Solubility; Temperature | 2023 |
Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Delirium; Female; Hip Fractures; Humans; | 2020 |
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase | 2019 |
Towards an Effective and Safe Treatment of Inflammatory Pain: A Delphi-Guided Expert Consensus.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Consensus; Health Knowledge, Att | 2019 |
Operating without opioids.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Celecoxib; Drug Combinations; Drug Prescriptions; Gen | 2019 |
Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Australia; Child; Child, Preschool; Chron | 2019 |
Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Arthritis; Behavioral Symptoms; Cohort Studies; Dose | 2020 |
Analgesic use at ovulation and implantation and human fertility.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Embryo Implantat | 2020 |
Central nervous system evaluation of an ethanol extract of Bidens odorata Cav (Asteraceae) leaves, and its antinociceptive interaction with paracetamol and naproxen.
Topics: Acetaminophen; Analgesics; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Ast | 2020 |
Osteoarthritis in Older Adults: Nonsteroidal Anti-Inflammatory Drugs Versus Opioids.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2019 |
Pain Patterns and Treatment Among Nursing Home Residents With Moderate-Severe Cognitive Impairment.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Paracetamol for pain in adults.
Topics: Acetaminophen; Drug Overdose; Humans; Osteoarthritis, Knee; Pain; Practice Guidelines as Topic | 2019 |
Reply.
Topics: Acetaminophen; Humans; Pain | 2020 |
Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dibenz | 2020 |
Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats.
Topics: Acetaminophen; Analgesics; Animals; Codeine; Drug Combinations; Male; Morphine; Paclitaxel; Pain; Ra | 2020 |
Pain Management in a Patient with Kidney Failure.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2020 |
Pain Management for Pediatric Burns in the Outpatient Setting: A Changing Paradigm?
Topics: Acetaminophen; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2020 |
Letter to the Editor Regarding "Intravenous Acetaminophen (Paracetamol) for Post-Craniotomy Pain; Systematic Review and Meta-Analysis of Randomized Clinical Trials".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Craniotomy; Humans; Pain; Randomized Controlled Trials as T | 2020 |
The effect of intraoperative intravenous acetaminophen on intraoperative and postoperative opioid use and pain scores in minimally invasive spine surgery.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Pa | 2020 |
Exploration of self-medication practice in Pokhara valley of Nepal.
Topics: Acetaminophen; Adult; Analgesics; Anti-Bacterial Agents; Common Cold; Cough; Cross-Sectional Studies | 2020 |
Pain during medical abortion in early pregnancy in teenage and adult women.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Adolescent; Adult; Analgesics; | 2020 |
Association Between Male Use of Pain Medication and Fecundability.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Rate; Cohort Studies; | 2020 |
A COVID-19 patient with intense burning pain.
Topics: Acetaminophen; Analgesics; Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome; Back Pain; | 2020 |
In Reply to the Letter to the Editor Regarding "Intravenous Acetaminophen (Paracetamol) for Postcraniotomy Pain; Systematic Review and Meta-analysis of Randomized Clinical Trials".
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Humans; Pain; Randomized Contr | 2020 |
Pain management modalities for hidradenitis suppurativa: a patient survey.
Topics: Acetaminophen; Female; Hidradenitis Suppurativa; Humans; Male; Pain; Pain Management; Severity of Il | 2022 |
Intravenous paracetamol for neonates: long-term diseases not escalated during 5 years of follow-up.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Apgar Score; Asthma; Birth Wei | 2021 |
Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
Topics: Acetaminophen; Advance Care Planning; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesic | 2020 |
The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Gene | 2021 |
Overcoming the paracetamol dose challenge with wrinkled mesoporous carbon spheres.
Topics: Acetaminophen; Carbon; COVID-19 Drug Treatment; Delayed-Action Preparations; Drug Carriers; Humans; | 2021 |
In acute soft tissue injuries, NSAIDs do not differ from acetaminophen for pain reduction.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain; Pharmaceutical Pre | 2020 |
Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Causality; Cohort Studies; Female; Gestational Age; Headach | 2021 |
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Comb | 2021 |
Evaluation of painkillers according to the principles of rational drug use in patients registered to a family medicine unit.
Topics: Acetaminophen; Analgesics; Family Practice; Female; Humans; Pain; Pharmaceutical Preparations | 2021 |
Pain and pain management the first two weeks after trauma.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain; Pai | 2021 |
Paracetamol or ibuprofen for fever or pain in children under 2 years old.
Topics: Acetaminophen; Antipyretics; Child; Fever; Humans; Ibuprofen; Infant; Pain | 2021 |
Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Blood Specimen Collection; Brain; Clinical Tri | 2021 |
In vitro and In vivo Synergistic Interactions of the Flavonoid Rutin with Paracetamol and with Non-Steroidal Anti-Inflammatory Drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Drug Synergism; | 2021 |
Intravenous Acetaminophen vs Intravenous Diclofenac in the Management of Painful Crisis in Sickle Cell Disease: Authors' Reply.
Topics: Acetaminophen; Administration, Intravenous; Anemia, Sickle Cell; Diclofenac; Humans; Pain | 2021 |
Intravenous Acetaminophen vs Intravenous Diclofenac in the Management of Painful Crisis in Sickle Cell Disease.
Topics: Acetaminophen; Administration, Intravenous; Anemia, Sickle Cell; Diclofenac; Humans; Pain | 2021 |
Tramadol oral solution (Qdolo) for pain.
Topics: Acetaminophen; Administration, Oral; Analgesics, Opioid; Child; Cytochrome P-450 CYP2D6; Female; Hum | 2021 |
Pain in nursing home residents with dementia and its association to quality of life.
Topics: Acetaminophen; Activities of Daily Living; Aged, 80 and over; Cross-Sectional Studies; Dementia; Fem | 2022 |
COVID-19'da İhmal Edilen Semptom: Ağrı.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; COVID-19; Humans; | 2021 |
Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes.
Topics: Acetaminophen; Autoimmune Diseases; Cohort Studies; Female; Humans; Infant, Newborn; Pain; Pre-Eclam | 2022 |
Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology.
Topics: Acetaminophen; Aged, 80 and over; Codeine; Drug Eruptions; Humans; Male; Nonprescription Drugs; Pain | 2021 |
Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Meta-Analysis as Topic; Osteoarthrit | 2021 |
Nonsteroidal Anti-inflammatory Drugs Alone or in Combination With Acetaminophen are Effective and Safe Treatments for Short-Term Pain Control in Nonsurgical Endodontic Treatment.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain; Pain Management; Pharmaceutica | 2021 |
Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Coh | 2017 |
Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Male; Nerve Fib | 2017 |
What is the dose of intravenous paracetamol for pain relief in neonates?
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Dose-Response Relationship, Dr | 2017 |
In Response: The Contribution of the Emergency Department to Opioid Pain Reliever Misuse and Diversion: A Critical Review.
Topics: Acetaminophen; Analgesics, Opioid; Emergency Service, Hospital; Humans; Opioid-Related Disorders; Pa | 2017 |
Pain in Children With Cancer: Prevalence, Characteristics, and Parent Management.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Caregivers; Child; Female; Humans; Male; Middle Aged | 2018 |
In Patients Having Hip or Knee Arthroplasty, Intravenous and Oral Acetaminophen Did Not Differ for 24-Hour Pain or Narcotic Use.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Humans; Narcotics; Pain; P | 2017 |
Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Diseas | 2018 |
Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Diterpenes; Gene Expression; Hyp | 2017 |
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.
Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Capsaicin; Cell Death; Cysteine; Ganglia, Spinal; HE | 2017 |
Response to Letter to the Editor The Contribution of the Emergency Department to Opioid Pain Reliever Misuse and Diversion: A Critical Review.
Topics: Acetaminophen; Analgesics, Opioid; Emergency Service, Hospital; Humans; Opioid-Related Disorders; Pa | 2017 |
Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort.
Topics: Acetaminophen; Adult; Analgesics; Dose-Response Relationship, Drug; Female; Fetal Blood; Gestational | 2017 |
Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biological Availability; Critical Illness; Cro | 2017 |
Expectations about the effectiveness of pain- and itch-relieving medication administered via different routes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Cross-Sectional Studies; Drug Administration Routes; Female; | 2018 |
Analyzing Analgesic Medications in Community-Dwelling Older Adults.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opi | 2019 |
Use of analgesics in France, following dextropropoxyphene withdrawal.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Codeine; Dextropropoxyphene; Drug Combinations; Drug | 2018 |
Salicytamide: a New Anti-inflammatory Designed Drug Candidate.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Edema; Mice; Nocicepti | 2018 |
Subcutaneous administration of paracetamol-Good local tolerability in palliative care patients: An observational study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Female; Humans; Male; Middl | 2018 |
Pain in children remains an unsolved problem.
Topics: Acetaminophen; Child; Emergency Service, Hospital; Humans; Ibuprofen; Pain | 2018 |
Pain relief: determining the safety of ibuprofen with postpartum preeclampsia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Hypertension; Ibuprofe | 2018 |
Prevalence and Characteristics of Moderate to Severe Pain among Hospitalized Older Adults.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2018 |
Participation of ATP-sensitive K+ channels and μ-opioid receptors in the antinociceptive synergism of the paracetamol-tapentadol co-administration in the formalin-induced pain assay in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr | 2018 |
There may be a small reduction in pain immediately after tooth bleaching when consuming codeine plus acetaminophen, but this is unlikely to be important to patients or worth the potential risks.
Topics: Acetaminophen; Codeine; Double-Blind Method; Drug Combinations; Humans; Ibuprofen; Pain; Tooth Bleac | 2019 |
Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis.
Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Brain; Central Nervous System; Endometriosis; | 2019 |
A Question of Opioid Diversion or Compliance.
Topics: Acetaminophen; Analgesics, Opioid; Brain Injuries, Traumatic; Chromatography, High Pressure Liquid; | 2019 |
What Is the Optimal Dose of Predniso(lo)ne for Induction of Remission in Patients With Autoimmune Hepatitis?
Topics: Acetaminophen; Hepatitis, Autoimmune; Humans; Pain; Prednisolone; Prednisone; Remission Induction | 2020 |
Beyond Opioids for Pain Management in Adult Critically Ill Patients.
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia; Analgesics; Analgesics, Non-N | 2019 |
Acetaminophen influences social and economic trust.
Topics: Acetaminophen; Adult; Female; Games, Experimental; Humans; Interpersonal Relations; Male; Pain; Resi | 2019 |
Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.
Topics: Acetaminophen; Animals; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Narcotics; Pain; | 2020 |
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age | 2019 |
Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, | 2019 |
Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief.
Topics: Acetaminophen; Analgesia; Cesarean Section; Female; Humans; Pain; Pain Management; Pregnancy | 2019 |
Use of paracetamol in ischaemic stroke patients: evidence from VISTA.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Brain Ischemia; Female; Fever; Hum | 2013 |
Semiological evaluation of pain according to its origin: a prospective, observational, and national study of current French medical practice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Combinations; Female; Fra | 2013 |
Analgesics for osteoarthritis.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi | 2013 |
Descriptive study of opioid-acetaminophen prescription patterns at the providence VA Medical Center.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug | 2013 |
To compare methods used in our operating room for alleviating tourniquet pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2013 |
[Efficacy of tramadol/acetaminophen medication for central post-stroke pain].
Topics: Acetaminophen; Aged; Female; Humans; Japan; Male; Middle Aged; Pain; Pain Measurement; Stroke; Trama | 2013 |
Managing osteoarthritis pain in the older population.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Age Factors; Aged; Aging; Analgesics, | 2013 |
Does format matter for comprehension of a facial affective scale and a numeric scale for pain by adults with Down syndrome?
Topics: Acetaminophen; Adult; Affect; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cog | 2013 |
Adult cancer pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Neoplasms; Pain; | 2013 |
Is it farewell to codeine?
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Child; Codeine; Humans; Pain; Treatment Outcom | 2013 |
The pill hustle: risky pain management for a gunshot victim.
Topics: Acetaminophen; Adult; Anthropology, Cultural; Black or African American; Drug Combinations; Health S | 2013 |
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce | 2014 |
Acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2013 |
Is fever treated more promptly than pain in the pediatric emergency department?
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Presch | 2014 |
Intravenous acetaminophen: an alternative to opioids for pain management?
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Evidence-B | 2013 |
Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
Topics: Acetaminophen; Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcoti | 2014 |
Identifying adults at risk of paracetamol toxicity in the acute dental setting: development of a clinical algorithm.
Topics: Acetaminophen; Adult; Algorithms; Analgesics, Non-Narcotic; Dental Care; Drug Overdose; Health Knowl | 2014 |
Acetaminophen safety: be cautious but not afraid. Read labels and stick to guidelines to prevent this widely used pain and fever remedy from harming your liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
Using acetaminophen safely.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2014 |
An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch.
Topics: Acetaminophen; Adolescent; Adult; Aged; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle | 2014 |
Pharmacological management of pain in Australian Aged Care Facilities.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics; Analgesics, Non-Narcotic; An | 2014 |
Patient recall of health care provider counseling for opioid-acetaminophen prescriptions.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Counseling; Cross-Sectional Studies; Drug Combinations; Fe | 2014 |
Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Drug Combinations; Drug Synergism; gamma-Aminobutyr | 2014 |
Deadly pain pills: everyday, 46 people in the U.S. die from legal pain pills. Here's how to avoid being a statistic.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdos | 2014 |
Clinical and pathologic characteristics of intranasal abuse of combined opioid-acetaminophen medications.
Topics: Acetaminophen; Administration, Intranasal; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid | 2014 |
Methods for calculating confidence and credible intervals for the residual between-study variance in random effects meta-regression models.
Topics: Acetaminophen; Analysis of Variance; Bayes Theorem; Confidence Intervals; Humans; Models, Statistica | 2014 |
Rescheduling of hydrocodone combination products.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Controlled Subs | 2014 |
A high-quality RCT documents that elderly with dementia, the most neglected pain patients, have effective and safe pain relief from paracetamol alone or with buprenorphine patch.
Topics: Acetaminophen; Analgesics; Buprenorphine; Clinical Protocols; Dementia; Female; gamma-Aminobutyric A | 2014 |
Pain in renal disease.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cystostomy; Female; Humans; Pain; Pain Management; P | 2014 |
Adaptation of an evidence-based clinical practice guideline in cancer pain management by medical oncologists: a case vignette study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Constipation; Cross-Sectional Studies; Evidence-Base | 2015 |
Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context.
Topics: Acetaminophen; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Brain; Carrageenan; Hyperalgesia; | 2015 |
"But it's just paracetamol": Caregivers' ability to administer over-the-counter painkillers to children with the information provided.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Caregivers; Child; Child, Preschool; Comprehension; Drug La | 2015 |
Painful acute radiation thyroiditis induced by 131I treatment of Graves' disease.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Anti-Inflammatory Agents; Drug Combinations; Female; Grave | 2015 |
Analgesic effects of rosemary essential oil and its interactions with codeine and paracetamol in mice.
Topics: Acetaminophen; Analgesics; Animals; Codeine; Drug Interactions; Female; Male; Mice; Oils, Volatile; | 2015 |
DEA reschedules hydrocodone combination products.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Attitude to Health; Drug and Narcotic Control; Drug C | 2015 |
Acetaminophen & children. Why have pediatric dosage guidelines changed, and what does it mean in practice?
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Preschool; Dose-Re | 2011 |
A retrospective cohort study of long-term immediate-release hydrocodone/acetaminophen use and acetaminophen dosing above the Food and Drug Administration recommended maximum daily limit among commercially insured individuals in the United States (2008-201
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cohor | 2015 |
Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diabetic Neuropathies; Dose-Response Relationship, Drug | 2015 |
Protein-Derived Acetaminophen-Cysteine Can Be Detected After Repeated Supratherapeutic Ingestion of Acetaminophen in the Absence of Hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver In | 2015 |
Optimal pain relief for pediatric MSK injury.
Topics: Acetaminophen; Analgesics; Canada; Child; Codeine; Drug Combinations; Humans; Ibuprofen; Morphine; M | 2015 |
Rationale for Use of Intravenous Acetaminophen in Special Operations Medicine.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; First Aid; Humans; Military Me | 2015 |
Patterning poly(maleic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer bioconjugates for controlled release of drugs.
Topics: Acetaminophen; Analgesics; Animals; Codeine; Delayed-Action Preparations; Drug Carriers; Drug Libera | 2015 |
Functional magnetic resonance imaging is a powerful approach to probing the mechanism of action of therapeutic drugs that act on the central nervous system.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Humans; Male; Pain | 2015 |
Acetaminophen: minimal relief for knee arthritis pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis; Humans; Knee Joint; Pain | 2015 |
Formulation optimization of a drug in adhesive transdermal analgesic patch.
Topics: Acetaminophen; Adhesives; Administration, Cutaneous; Analgesics; Animals; Chemistry, Pharmaceutical; | 2016 |
Safety and Tolerability of Biphasic Immediate-Release/Extended-Release Oxycodone/Acetaminophen Tablets: Analysis of 11 Clinical Trials.
Topics: Acetaminophen; Adult; Analgesics; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combin | 2016 |
Protein-derived acetaminophen-cysteine detection from chronic APAP is not dose-dependent.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cysteine; Female; Humans; Male; Pain | 2015 |
Reply to Dr. Regina and colleagues re: protein-derived acetaminophen-cysteine in supratherapeutic ingestion.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cysteine; Female; Humans; Male; Pain | 2015 |
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu | 2016 |
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu | 2016 |
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu | 2016 |
Intravenous Paracetamol Decreases Requirements of Morphine in Very Preterm Infants.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hu | 2016 |
Comparison of intravenous morphine and paracetamol.
Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Ank | 2015 |
Pain management during radiotherapy and radiochemotherapy in oropharyngeal cancer patients: single-institution experience.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Prevalence, trends, patterns and associations of analgesic use in Germany.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics; Aspirin; Diclofenac; Drug Therapy; | 2015 |
Combination of paracetamol or ketamine with meperidine enhances antinociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr | 2016 |
NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2016 |
Treating Pain in Preterm Infants: Moving from Opioids to Acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Male; Morphine; Pain | 2016 |
[INFULGAN-OPTIMAL ANALGETIC DRUG FOR USE IN LAPAROSCOPIC SURGERY].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Antipyretics; Appendectomy; Chil | 2015 |
Nonsurgical Management of Knee Pain in Adults.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities.
Topics: Acetaminophen; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ster | 2015 |
Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Benzofurans; Conditioning | 2016 |
Pain medication in German nursing homes: a whole lot of metamizole.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Cross-Sectional Studies; Dipyrone; Dose-Response | 2016 |
Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen.
Topics: Acetaminophen; Administration, Intravenous; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical an | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Prevention and Management of Procedural Pain in the Neonate: An Update.
Topics: Acetaminophen; Acoustic Stimulation; Administration, Topical; Analgesics, Non-Narcotic; Analgesics, | 2016 |
Non-steroidal anti-inflammatory drugs and paracetamol in self-therapy of various disorders in students of different fields of study.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional Studies; Female; Heal | 2015 |
Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Codeine; | 2016 |
In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Infant, Newborn; Morphine; Pain | 2016 |
Common pain relievers may increase heart problems. High-dosage ibuprofen and diclofenac linked to elevated risk of death; naproxen, acetaminophen offer alternatives.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Ibuprofen; Naproxen; Pai | 2010 |
Early management in children with burns: Cooling, wound care and pain management.
Topics: Acetaminophen; Adolescent; Analgesics; Bandages; Burns; Child; Child, Preschool; Cryotherapy; Early | 2016 |
Paracetamol + opium (Izalgi) higher-dose for oral administration. A poor choice for analgesia.
Topics: Acetaminophen; Administration, Oral; Drug Therapy, Combination; Humans; Opium; Pain | 2016 |
Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better.
Topics: Acetaminophen; Aged; Analgesics; Dose-Response Relationship, Drug; Drug Combinations; Drug Monitorin | 2016 |
Paracetamol: pharmacology, prescribing and controversies.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans; | 2016 |
What are the therapeutic alternatives to dextropropoxyphene in France? A prescribers' survey.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesiologists; Anesthesiolog | 2017 |
[Palliative medicine--drug therapy for cancer pain].
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Male; Pain; Pall | 2016 |
Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 | 2016 |
Unusual foreign body in primary tooth.
Topics: Acetaminophen; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Foreign Bodies; Humans; Male; | 2016 |
The Decline in Hydrocodone/Acetaminophen Prescriptions in Emergency Departments in the Veterans Health Administration Between 2009 to 2015.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Drug Prescriptions; Emergency Ser | 2016 |
Experiences of Pain and Expectations for Its Treatment Among Former Buruli Ulcer Patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents | 2016 |
Acetaminophen study yields new insights into neurobiological underpinnings of empathy.
Topics: Acetaminophen; Emotions; Empathy; Humans; Pain; Social Behavior | 2017 |
Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study.
Topics: Acetaminophen; Adult; Analgesics; Antipyretics; Caregivers; Cross-Sectional Studies; Culture; Female | 2017 |
Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Aspirin; Female; Humans; Ibuprofen; Internet; | 2017 |
Teething.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Humans; Ibuprofen; Infant; Materia Medica; Pain | 2016 |
Prenatal acetaminophen use and outcomes in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans; Neurodevelo | 2017 |
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In | 2017 |
The relation between paracetamol use and asthma: a GA2LEN European case-control study.
Topics: Acetaminophen; Adult; Analgesics; Asthma; Case-Control Studies; Europe; Female; Humans; Male; Middle | 2008 |
Acetaminophen prevents hyperalgesia in central pain cascade.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Dinoprostone; Hyperalgesia; | 2008 |
Dextropropoxyphene: welcome withdrawal from a French hospital's formulary.
Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug Overdose; Drug Therapy, Combination; Dru | 2008 |
Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Dose-Respo | 2009 |
Listen to the patient.
Topics: Acetaminophen; Bicarbonates; Deglutition Disorders; Drug Combinations; Female; Fractures, Bone; Huma | 2008 |
Pro-drugs for indirect cannabinoids as therapeutic agents.
Topics: Acetaminophen; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Humans; Pain; | 2008 |
GP management of osteoarthritic pain in Hong Kong.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional St | 2008 |
Antinociceptive activity of swertiamarin isolated from Enicostemma axillare.
Topics: Acetaminophen; Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Gentianaceae; Glucosides; | 2009 |
How to make screening mammography less uncomfortable.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen | 2008 |
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk?
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and | 2009 |
Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Disease Models, An | 2009 |
The synergistic interaction between rilmenidine and paracetamol in the writhing test in mice.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Th | 2009 |
Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Dextropropoxyphene; Drug Overdose; Drug Therapy | 2009 |
Survey of i.v. paracetamol (acetaminophen) use in neonates and infants under 1 year of age by UK anesthetists.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anesthesia; Drug Utilization; Female; Health C | 2009 |
Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dis | 2009 |
[Update on current care guidelines. Safe use of non-steroidal anti-inflammatory drugs].
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Middle Aged | 2009 |
Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Infl | 2009 |
Comment from the editor on Lambertz et al in the September 2008 issue.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Lidocaine; Mammogra | 2009 |
The analgesic effects of oral paracetamol in two strains of mice undergoing vasectomy.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dose-Respo | 2009 |
The analgesic effect of decursinol.
Topics: Acetaminophen; Acetic Acid; Analgesics; Angelica; Animals; Aspirin; Benzopyrans; Butyrates; Disease | 2009 |
Antinociceptive activity of a new benzofuranone derived from a chalcone.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalc | 2009 |
Acetaminophen safety - deja vu.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Consumer Pro | 2009 |
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitacea | 2009 |
Aspirin or paracetamol - what's good for you?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical | 2009 |
[Treatment of sickle cell pain].
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Child; Female; Humans; Mal | 2009 |
Alleviation of pain associated with immunization injections.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Immunization; Injections; Pain; Vaccines | 2009 |
Dextropropoxyphene: withdrawn in the EU. Withdrawn from pharmacies in France.
Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug and Narcotic Control; Drug Combinations; | 2009 |
Dextropropoxyphene: withdrawal from the US market requested: harmful drug.
Topics: Acetaminophen; Analgesics, Opioid; Dextropropoxyphene; Drug and Narcotic Control; Drug Combinations; | 2009 |
A determination of submicromolar concentrations of glycine in periaqueductal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Electric Conductivity; Electrophoresi | 2009 |
A difficult balance--pain management, drug safety, and the FDA.
Topics: Acetaminophen; Advisory Committees; Analgesics; Analgesics, Opioid; Drug and Narcotic Control; Drug | 2009 |
Is acetaminophen safe? Accidental overdoses are common, but avoidable.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Labeling; Drug | 2010 |
Posttraumatic psoriatic osteitis of the frontal bone successfully treated with etanercept. Report of a case.
Topics: Acetaminophen; Anti-Inflammatory Agents; Child; Craniocerebral Trauma; Drug Therapy, Combination; Et | 2010 |
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Disease Mode | 2010 |
Trauma and substance abuse: deadly consequences of intravenous percocet tablets.
Topics: Acetaminophen; Adult; Craniocerebral Trauma; Drug Combinations; Emergency Service, Hospital; Facial | 2012 |
[44 year old gardener with lower back pain, myalgia and fever].
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Clinical Trials as T | 2010 |
Synergism between COX-3 inhibitors in two animal models of pain.
Topics: Acetaminophen; Animals; Cyclooxygenase Inhibitors; Dipyrone; Disease Models, Animal; Drug Synergism; | 2010 |
Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Response | 2009 |
Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents.
Topics: Acetaminophen; Acetic Acid; Algorithms; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Carbamaz | 2010 |
FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
Topics: Acetaminophen; Advisory Committees; Alcohol Drinking; Analgesics, Opioid; Anti-Inflammatory Agents, | 2010 |
Reducing delirium in elderly patients with hip fracture: a multi-factorial intervention study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Anesthesia, General; Anesthesia, Spinal; Choline | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
Pain prevalence in patients with chronic kidney disease.
Topics: Acetaminophen; Activities of Daily Living; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory | 2010 |
Triage pain scales cannot predict analgesia provision to pediatric patients with long-bone fracture.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chi-Square Distribution; Ch | 2010 |
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.
Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; M | 2010 |
[Pain perception and pain therapy in premature infants].
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Infant; | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Acetaminophen reduces social pain: behavioral and neural evidence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Brain Mapping; Female; Humans; Interpersonal Relatio | 2010 |
Effects of high dose orally administered paracetamol for heel prick pain in premature infants.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Heel; Humans; Infant, New | 2010 |
Re: lack of benefit from paracetamol (acetaminophen) for palliative cancer patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method | 2010 |
Individualized pharmacological treatment of oral mucositis pain in patients with head and neck cancer receiving radiotherapy.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2011 |
Bundle up: it's painful out there--the case for opioid-acetaminophen combinations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Combinations; Humans; Pain; Produc | 2010 |
Predictors of pain relief and adverse events in patients receiving opioids in a prehospital setting.
Topics: Acetaminophen; Adult; Aged; Ambulances; Analgesics, Non-Narcotic; Analgesics, Opioid; Confidence Int | 2011 |
Retiform hemangioendothelioma presenting as a hyperhidrotic tumor.
Topics: Acetaminophen; Biopsy; Female; Hemangioendothelioma; Humans; Hyperhidrosis; Middle Aged; Pain; Skin | 2010 |
Blood pressure destabilization on nonsteroidal antiinflammatory agents: acetaminophen exposed?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Dos | 2010 |
A primer on pain relief.
Topics: Acetaminophen; Analgesia; Analgesics; Aspirin; Humans; Ibuprofen; Naproxen; Nonprescription Drugs; P | 2010 |
Risk of hepatotoxicity-related hospitalizations among patients treated with opioid/acetaminophen combination prescription pain medications.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Drug Combina | 2010 |
A 3-year-old trauma patient with progressive paralysis.
Topics: Accidents, Traffic; Acetaminophen; Analgesics, Non-Narcotic; Catheters, Indwelling; Child, Preschool | 2010 |
Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Drug Therapy, Combination; Female; Humans; Male; Middle Age | 2010 |
Acetaminophen induces apoptosis in rat cortical neurons.
Topics: Acetaminophen; Animals; Antioxidants; Antipyretics; Apoptosis; Benzimidazoles; Cytochrome P-450 CYP2 | 2010 |
Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, An | 2011 |
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice; | 2011 |
Pain management of children and adolescents with sickle cell disease presenting to the emergency department.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Anti-I | 2011 |
The pharmacokinetics of intravenous paracetamol in neonates: size matters most.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Weight; Drug Administration Schedule; Gestational Age; | 2011 |
Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Hydr | 2011 |
Pain perception during and after VNUS ClosureFAST™ procedure.
Topics: Acetaminophen; Aged; Catheter Ablation; Cohort Studies; Female; Humans; Male; Middle Aged; Pain; Pai | 2011 |
Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; | 2011 |
Pain relief in neonates: when to use intravenous paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Administration Schedule; Humans; Infant, Newborn; Inje | 2011 |
Acetaminophen may boost blood pressure. Caution, attention should accompany routine use of any pain medicine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Pressure; Heart Rate; Humans; Hypertension; Pain; Vas | 2011 |
Antinociceptive effects of combination of tramadol and acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats.
Topics: Acetaminophen; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combin | 2011 |
Adherence and long-term effect of oxycodone/paracetamol in chronic noncancer pain: a retrospective study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; M | 2011 |
FDA limits prescription acetaminophen. But be vigilant about over-the-counter acetaminophen, too.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2011 |
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Celecoxib; Codein | 2011 |
Pediatric pain management.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Human | 2011 |
Is there a role for intravenous acetaminophen in pediatric emergency departments?
Topics: Acetaminophen; Adolescent; Analgesia; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Hum | 2011 |
Rapid hypnosis as an anaesthesia adjunct for evacuation of postpartum vulval haematoma.
Topics: Acetaminophen; Adult; Anesthetics, Intravenous; Blood Loss, Surgical; Female; Fentanyl; Hematoma; Hu | 2011 |
Medication, surgery, and physiotherapy among patients with the hypermobility type of Ehlers-Danlos syndrome.
Topics: Acetaminophen; Activities of Daily Living; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti | 2011 |
Misuse of acetaminophen in the management of dental pain.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum | 2011 |
Fatigue in knee and hip osteoarthritis: the role of pain and physical function.
Topics: Acetaminophen; Activities of Daily Living; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-S | 2011 |
Effects of the analgesic acetaminophen (Paracetamol) and its para-aminophenol metabolite on viability of mouse-cultured cortical neurons.
Topics: Acetaminophen; Aminophenols; Analgesics; Animals; Brain; Cell Survival; Cells, Cultured; Mice; Mice, | 2012 |
Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Knee Joint; Male; Pain | 2011 |
Use of acetaminophen (paracetamol) as a short-term adjunctive analgesic in a laminitic pony.
Topics: Acetaminophen; Analgesia; Analgesics; Animals; Fatal Outcome; Foot Diseases; Hoof and Claw; Horse Di | 2011 |
[Pain assessment in terminally-ill cancer patients on admission in hospice and its modification after the first three days of care. A monocentric experience].
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Drug Therapy, Combination; | 2011 |
Suspected opioid overdose case resolved by CYP2D6 genotyping.
Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Caffeine; Codeine; Cytochrome P-450 CYP2D6; Drug Comb | 2012 |
Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Antipyretics; Behavior, Animal; Bignoniaceae; Disea | 2010 |
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A | 2012 |
Alternating acetaminophen and ibuprofen for pain in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres | 2012 |
Intrapartum fetal pain management in lethal osteogenesis imperfecta.
Topics: Acetaminophen; Adult; Analgesia; Breech Presentation; Fatal Outcome; Female; Fetal Diseases; Humans; | 2012 |
[Mechanism of action of paracetamol--further contribution to discovery].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Calcium Channels; Dronabinol; H | 2012 |
Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Caregivers; Child; Child, Preschool; Dru | 2012 |
Older adults living with osteoarthritis: examining the relationship of age and gender to medicine use.
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents | 2012 |
The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study.
Topics: Acetaminophen; Administration, Topical; Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Ant | 2013 |
Use of intravenous acetaminophen (paracetamol) in a pediatric patient at the end of life: case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fatal Outcome; Female; Humans; Injections, Intraveno | 2013 |
Effect of pain management on immunization efficacy in mice.
Topics: Acetaminophen; Analgesia; Analgesics; Animals; Animals, Laboratory; Antibody Formation; Behavior, An | 2012 |
Basic pain relievers. It's wise to use caution.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induc | 2012 |
Association of pain score documentation and analgesic use in a pediatric emergency department.
Topics: Acetaminophen; Administration, Oral; Adolescent; Age Factors; Analgesics; Child; Child, Preschool; D | 2012 |
Prescription patterns of pain medicine physicians.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Drug Prescriptions; Humans; Methadone; Opioid-Related | 2013 |
Subcutaneous migration of a central venous catheter.
Topics: Acetaminophen; Aged; Catheterization, Central Venous; Central Venous Catheters; Female; Foreign-Body | 2013 |
Non-prescription medicines for pain and fever--a comparison of recommendations and counseling from staff in pharmacy and general sales stores.
Topics: Acetaminophen; Analgesics; Antipyretics; Aspirin; Child; Commerce; Contraindications; Counseling; Fe | 2013 |
Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors.
Topics: Acetaminophen; Adenosine A1 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Male; Mice; Mic | 2013 |
Can intravenous paracetamol reduce opioid use in preoperative hip fracture patients?
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Hip Fr | 2013 |
Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care Facilities; | 2013 |
Pain management in the elderly.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Pain; Pain Management; Pa | 2002 |
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat.
Topics: Acetaminophen; Aging; Analgesics; Animals; Aspirin; Clomipramine; Dose-Response Relationship, Drug; | 2002 |
Medicine: lipid signals in pain control.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygen | 2002 |
Re: combination analgesic efficacy.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinatio | 2002 |
Guidelines on pain control in seniors favor certain NSAIDs and strategies for the cognitively impaired.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cognition Disorders; Human | 2002 |
Acetaminophen and hypertension: a causal association or pain mediated?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Ca | 2003 |
Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: a novel heat allodynia model sensitive to analgesics.
Topics: Acetaminophen; Analgesics; Animals; Diclofenac; Diterpenes; Dose-Response Relationship, Drug; Female | 2003 |
Switching from i.v. to p.o.
Topics: Acetaminophen; Administration, Oral; Drug Combinations; Humans; Infusions, Intravenous; Male; Narcot | 2003 |
Paracetamol is the drug of choice for childhood pain and fever.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Infant; Pain | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
The sublingual administration of curare.
Topics: Acetaminophen; Administration, Sublingual; Curare; Humans; Mephenesin; Pain; Pain Management; Tubocu | 1953 |
[Napatyl, a new analgesic; clinical evaluation of N-acetyl-p-aminophenol with codeine].
Topics: Acetaminophen; Acetanilides; Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Codeine; P | 1956 |
USE OF A 'SOMA' COMPOUND IN PAIN CONTROL AFTER ORAL SURGERY.
Topics: Acetaminophen; Amphetamine; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthesia, Dental; An | 1963 |
[CLINICAL TRIALS WITH LONARID IN ORTHOPEDICS].
Topics: Acetaminophen; Biomedical Research; Fractures, Bone; Humans; Joint Diseases; Orthopedic Procedures; | 1964 |
ETHCHLORVYNOL AND PARACETAMOL. A CLINICAL EVALUATION OF AN HYPNOTIC/ANALGESIC COMBINATION.
Topics: Acetaminophen; Analgesics; Biomedical Research; Drug Synergism; Drug Therapy; Ethchlorvynol; Humans; | 1964 |
Paracetamol for injection: new formulation. New formulation: why so widely used?
Topics: Acetaminophen; Adult; Child; Clinical Trials as Topic; Drug Approval; Fever; France; Humans; Infusio | 2003 |
Administering acetaminophen safely.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Interactions; Drug Overdose; Humans; Pain | 2003 |
Older adults with Alzheimer disease, comorbid arthritis and prescription of psychotropic medications.
Topics: Acetaminophen; Aged; Aged, 80 and over; Alzheimer Disease; Analgesics; Arthritis; Benzodiazepines; C | 2003 |
Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age.
Topics: Acetaminophen; Analgesia; Analgesics; Betamethasone; Birth Weight; Female; Gestational Age; Half-Lif | 2004 |
Stability of tramadol hydrochloride--acetaminophen (Ultracet) in strawberry syrup and in a sugar-free vehicle.
Topics: Acetaminophen; Analgesics, Opioid; Child; Chromatography, High Pressure Liquid; Dosage Forms; Drug C | 2004 |
Paracetamol + tramadol: new preparation. No advance.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codein | 2003 |
Information from your family doctor. Chronic pain medicines.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise | 2004 |
Information from your family doctor. Pain relievers: understanding your options.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Decision Making; Humans; | 2004 |
Weak opiate analgesics: modest practical merits.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2004 |
The complexity of managing pain for frail elders.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise | 2004 |
Acetaminophen dose accuracy and pediatric emergency care.
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflamma | 2004 |
Analgesic prescription patterns among hemodialysis patients in the DOPPS: potential for underprescription.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cycloo | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Pain--the enigmatic entity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; | 2004 |
[Systematic pain treatment following Colles' fracture].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2004 |
A 64 year old woman with knee pain: case outcome.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Decision Making; Drug Interactions; Femal | 2004 |
A prospective study of nurse initiated panadeine forte: expanding pain management in the ED.
Topics: Acetaminophen; Adult; Analgesia; Australia; Clinical Nursing Research; Clinical Protocols; Codeine; | 2004 |
Future Pain Drugs - Europe 2003. 15-16 September 2003, London, UK.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2003 |
Antalgic effect and clinical tolerability of hyaluronic acid in patients with degenerative diseases of knee cartilage: an outpatient treatment survey.
Topics: Acetaminophen; Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Dru | 2004 |
Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats.
Topics: Acetaminophen; Acetylcholine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Stero | 2004 |
Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Combinatio | 2004 |
Balancing pain and analgesic treatment in the home-dwelling elderly.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2005 |
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis.
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Human | 2005 |
Treating pain after Vioxx. Should you switch to another COX-2, a traditional non-steroidal anti-inflammatory, or acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inh | 2005 |
Acetaminophen in cancer pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Neoplasms; Pain; Palliative Care | 2005 |
[Arthrosis pain: a frequent problem. Paracetamol is the first choice according to EULAR recommendation].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Arthritis; Clinical Trials as Topic; Humans; Multice | 2005 |
Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Behavior, Animal; Cytokines; Dose-Response Relationship | 2005 |
[Data recording using a personal digital assistant. Experience of prospective survey on pain in 3196 patients].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Computers, Handheld; Data Collection; Family Practice; Fema | 2005 |
Rates of abuse of tramadol remain unchanged with the introduction of new branded and generic products: results of an abuse monitoring system, 1994-2004.
Topics: Acetaminophen; Analgesics, Opioid; Drug Prescriptions; Drugs, Generic; Humans; Narcotics; Opioid-Rel | 2005 |
Bupivacaine versus lidocaine analgesia for neonatal circumcision.
Topics: Acetaminophen; Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; C | 2005 |
[Aspirin, paracetamol, ibuprofen: analgesics in the family medicine cabinet].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraind | 2005 |
Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non- | 2005 |
Are nursing home patients with dementia diagnosis at increased risk for inadequate pain treatment?
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Cognition Disorders; C | 2005 |
Report of an adverse incident in a randomized clinical trial.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Child; Drug Hypers | 2005 |
Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome.
Topics: Accidents, Traffic; Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Barbi | 2005 |
Opioids for non-operable osteoarthritis and soft-tissue rheumatism.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, | 2005 |
Pharmaceutical prescribing for children. Part 2. Analgesia and prescribing for children in pain.
Topics: Acetaminophen; Adolescent; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammato | 2005 |
Circadian pattern of spontaneous behavior in monarthritic rats: a novel global approach to evaluation of chronic pain and treatment effectiveness.
Topics: Acetaminophen; Activity Cycles; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri | 2005 |
Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Adult; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Data Colle | 2005 |
Managing patients with cancer and advanced liver disease.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Contraindicatio | 2005 |
Determining pain levels in patients treated with maggot debridement therapy.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2005 |
Patient's page. Bone health facts.
Topics: Acetaminophen; Adult; Child; Child Abuse; Chronic Disease; Female; Humans; Male; Pain; Pain Manageme | 2005 |
Use of acetaminophen in young subelite athletes.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Bicycling; Case-Control S | 2005 |
Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice.
Topics: Acetaminophen; Adenosine A2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Caffeine; Centr | 2006 |
Paediatric prehospital analgesia in Auckland.
Topics: Acetaminophen; Adolescent; Age Factors; Analgesia; Analgesics; Burns; Child; Child, Preschool; Drug | 2006 |
Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Stero | 2006 |
Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine.
Topics: Acetaminophen; Animals; Aspirin; Brain; Caffeine; Corpus Striatum; Dopamine; Male; Norepinephrine; P | 2006 |
Common pain reliever may promote social interaction in people with dementia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dementia; Humans; Interpersonal Relations; Pain | 2006 |
Drug therapy in dental practice: nonopioid and opioid analgesics.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2005 |
Pain relievers and alcohol. A potentially risky combination.
Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Interacti | 2006 |
Glucosamine and chondroitin sulfate for knee osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfat | 2006 |
[Paracetamol has the same effect as non-steroidal anti-inflammatory agents in acute musculoskeletal injuries].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans | 2006 |
Comparison of a scheduled narcotic for chronic pain with a similar medication for breakthrough pain only is not a clinically relevant comparison.
Topics: Acetaminophen; Chronic Disease; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Therapy, Co | 2006 |
Antinociceptive effects of synthetic chalcones obtained from xanthoxyline.
Topics: Acetaminophen; Acetic Acid; Acetophenones; Administration, Oral; Analgesics; Animals; Aspirin; Chalc | 2006 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; | 2006 |
[Dextromethorphan enhances analgesic activity of propacetamol--experimental study].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response | 2005 |
Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol.
Topics: Acetaminophen; Acute Disease; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, N | 2007 |
Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Animals; Cyclooxygenase Inhibitors; Mitogen-Acti | 2007 |
Tramadol infusion for the pain management in sickle cell disease: a case report.
Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch | 2007 |
Is killing the pain worth the risk?
Topics: Acetaminophen; Analgesics; Dextropropoxyphene; Drug Approval; Drug Combinations; Humans; Pain; Unite | 2007 |
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima | 2007 |
Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Dose-Response Rela | 2007 |
Comparing effectiveness of pain relievers in children.
Topics: Acetaminophen; Adolescent; Analgesics; Child; Codeine; Emergencies; Humans; Pain; Wounds and Injurie | 2007 |
Acute pain in adults admitted to the emergency room: development and implementation of abbreviated guidelines.
Topics: Acetaminophen; Acute Disease; Algorithms; Analgesics, Non-Narcotic; Analgesics, Opioid; Decision Tre | 2007 |
[Ankylosing spondylarthritis--what is new in diagnosis and therapy?].
Topics: Acetaminophen; Antibodies, Monoclonal; Antirheumatic Agents; Diagnosis, Differential; Humans; Pain; | 2006 |
Do we need to incorporate pharmacogenetics in randomized, controlled trials of frequently used medicines?
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2007 |
Intraoperative analgesia for day-care surgery: practice trends.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anal | 2007 |
Intravenous paracetamol for pain relief in a patient with neuropathic pain.
Topics: Acetaminophen; Amputation, Surgical; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Infusions | 2007 |
[Ambulatory pain management for children in the family practice].
Topics: Acetaminophen; Acute Disease; Ambulatory Care; Analgesics; Analgesics, Opioid; Child; Chronic Diseas | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Acetaminophen toxicity: changing perceptions on a social/medical issue.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug and Narcotic Control; Drug Industry; Drug Labeling; Hu | 2007 |
Periosteal reaction in systemic lupus erythematosus.
Topics: Acetaminophen; Analgesics, Opioid; Female; Femur; Humans; Knee; Lupus Erythematosus, Systemic; Osteo | 2007 |
Introduction and audit of intravenous paracetamol at a tertiary paediatric teaching hospital.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Australia; Child; Child, Preschool; Drug Utiliz | 2007 |
Primary care treatment of knee pain--a survey in older adults.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cryotherapy; Exerc | 2007 |
Acetaminophen reinforces descending inhibitory pain pathways.
Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain; | 2008 |
Acetaminophen reinforces descending inhibitory pain pathways.
Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain; | 2008 |
Acetaminophen reinforces descending inhibitory pain pathways.
Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain; | 2008 |
Acetaminophen reinforces descending inhibitory pain pathways.
Topics: Acetaminophen; Adult; Area Under Curve; Cross-Over Studies; Double-Blind Method; Humans; Male; Pain; | 2008 |
Analgesic efficacy of orodispersible paracetamol in patients admitted to the emergency department with an osteoarticular injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bone and Bones; Emergency Service, Hospital; Female; | 2007 |
Antinociceptive action of limonexic acid obtained from Raulinoa echinata.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Dru | 2007 |
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; An | 2008 |
Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Attitude to Death; Codeine; D | 2008 |
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical | 2007 |
Frontal lobotomy for the relief of intractable pain.
Topics: Acetaminophen; Frontal Lobe; Humans; Pain; Pain Management; Pain, Intractable; Personality; Personal | 1950 |
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Dipyrone; Disease Models, Animal; Hyp | 2008 |
Imatinib-induced fatal acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzamides; Fatal Outcome; Female; H | 2007 |
Pain medications. What you should know.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Hum | 2007 |
[Atypical pain in the mandible caused by trigeminal neuralgia].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Diagnosis, Differential; Female; Humans; Magnetic Resonance | 2008 |
Use of over-the-counter analgesics in patients with chronic liver disease: physicians' recommendations.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2008 |
[Pharmacotherapy with zaldiar of the pain syndrome in diabetic polyneuropathy].
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Diab | 2007 |
Hepatic tolerance of repeated intravenous paracetamol administration in neonates.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Belgium; Humans; Infant; Infant, Newborn; Injections, Intra | 2008 |
Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl-phenolamine (AM404) in the rat: comparison with paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Frontal Lobe; Hydroxyindoleacet | 2008 |
Pain management in Swedish neonatal units--a national survey.
Topics: Acetaminophen; Analgesics; Data Collection; Guideline Adherence; Humans; Infant, Newborn; Intensive | 2008 |
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug | 2008 |
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug | 2008 |
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug | 2008 |
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia.
Topics: Acetaminophen; Analgesia; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug | 2008 |
Efficiency of a muscle relaxant-analgesic combination in general practice.
Topics: Acetaminophen; Humans; Muscles; Orphenadrine; Pain | 1967 |
Interaction of analgesic effects of psychopharmaca.
Topics: Acetaminophen; Analgesics; Animals; Antidepressive Agents; Central Nervous System; Drug Antagonism; | 1967 |
Acute renal failure after acetaminophen ingestion.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Amylases; Creatine Kinase; Female; Humans; Liver; Pain; T | 1982 |
The management of the patient with chronic pain due to advanced malignancy.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Drug Therapy, Combination; Humans; Narcotics; N | 1982 |
Strained abdominal muscles as a cause of acute abdominal pain in children and young adults and its treatment with Paramax.
Topics: Abdomen; Abdominal Muscles; Acetaminophen; Adolescent; Adult; Child; Drug Combinations; Female; Huma | 1983 |
Peripherally acting analgesics.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Aspirin; Diflunisal; Fenoprofen; Humans; Ibupro | 1984 |
Pain and inflammation.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Osteoarthritis; Pai | 1984 |
The influence of paracetamol on the anti-inflammatory, the anti-pyretic and the analgesic activity of indomethacin.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Indo | 1983 |
Gastric emptying and drug absorption before surgery.
Topics: Acetaminophen; Adult; Aged; Anxiety; Emergencies; Female; Gastric Emptying; Humans; Intestinal Absor | 1984 |
Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis.
Topics: Acetaminophen; Arthritis, Rheumatoid; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Dr | 1984 |
Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Codeine; Dextropropoxyphene; Male; Mefenamic Acid; Mice | 1984 |
Acetaminophen: a practical pharmacologic overview.
Topics: Acetaminophen; Adolescent; Adult; Child; Child, Preschool; Fever; Humans; Infant; Kidney; Liver; Met | 1984 |
[Weighing the risk of weakly active analgesics. Paraminophenol and pyrazole derivatives. Conclusion].
Topics: Acetaminophen; Humans; Pain; Phenacetin; Pyrazoles; Risk | 1982 |
How to relieve your patients' pain fast and effectively ... with oral analgesics.
Topics: Acetaminophen; Administration, Oral; Analgesics; Aspirin; Humans; Narcotics; Pain | 1980 |
Evaluation of acetaminophen and aspirin in the relief of preoperative dental pain.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Mouth Diseases; | 1980 |
Pharmacological treatment of cancer pain with special reference to the oral use of morphine.
Topics: Acetaminophen; Administration, Oral; Aspirin; Biological Availability; Chronic Disease; Codeine; Hum | 1982 |
Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children.
Topics: Acetaminophen; Adolescent; Aspirin; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; F | 1982 |
[Paracetamol, pharmacodynamic, clinical toxicology and pharmacokinetic].
Topics: Acetaminophen; Dose-Response Relationship, Drug; Fever; Half-Life; Humans; Intestinal Absorption; Ki | 1982 |
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E | 1980 |
Newer concepts in pain therapy by applied pharmacology of the analgesics.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Humans; Hydroxyzine; Morphine; Morphine Derivat | 1981 |
Potentiation of acetaminophen hepatotoxicity by alcohol.
Topics: Acetaminophen; Adult; Alcoholism; Drug Synergism; Ethanol; Humans; Liver; Male; Middle Aged; Necrosi | 1980 |
How safe is acetaminophen?
Topics: Acetaminophen; Aspartate Aminotransferases; Drug Synergism; Ethanol; Humans; Liver; Microsomes, Live | 1980 |
A four-drug pain regimen for head and neck cancers.
Topics: Acetaminophen; Adult; Aged; Antidepressive Agents, Tricyclic; Drug Administration Schedule; Drug The | 1994 |
Relative potency of two preparations in two-way elimination of heterogeneity designs with multivariate responses.
Topics: Acetaminophen; Analgesia; Analgesics; Biometry; Caffeine; Dentistry; Humans; Mathematics; Models, St | 1995 |
[Treatment of pain and anxiety in terminal oncologic patients in the Castilla-La Mancha community].
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anxiety; Female; Humans; Ma | 1995 |
Non-steroidal anti-inflammatory drugs in elderly people. Treat mild chronic pain with paracetamol initially.
Topics: Acetaminophen; Aged; Chronic Disease; Humans; Pain | 1995 |
Post-operative morbidity following paediatric tonsillectomy; a comparison of bipolar diathermy dissection and blunt dissection.
Topics: Acetaminophen; Adenoidectomy; Adolescent; Child; Child, Preschool; Diathermy; Female; Hemorrhage; Hu | 1995 |
[Drugs for relief of pain].
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive | 1994 |
Management of cancer pain: adults. Agency for Health Care Policy and Research.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Behavior Therapy; C | 1994 |
[Paracetamol].
Topics: Acetaminophen; Fever; Humans; Pain | 1994 |
Drugs for pain.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy | 1993 |
Paracetamol and acute biliary pain with cholestasis.
Topics: Acetaminophen; Acute Disease; Adult; Cholestasis; Female; Humans; Pain | 1993 |
Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat.
Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Drug Combinations; Drug Synergism; Female; H | 1993 |
Alternatives to non-steroidal anti-inflammatory drugs (NSAIDS)
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Australia; Humans; Pain; Sodium Salicylate | 1993 |
Osteoarthritis treatment update. Minimizing pain while limiting patient risk.
Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Stero | 1993 |
The formalin test in the naked mole-rat (Heterocephalus glaber): analgesic effects of morphine, nefopam and paracetamol.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Formalde | 1993 |
Is prescribing paracetamol 'pro re nata' acceptable?
Topics: Acetaminophen; Child; Child, Preschool; Drug Administration Schedule; Drug Utilization; Fever; Human | 1993 |
12 years on: coproxamol revisited.
Topics: Acetaminophen; Dextropropoxyphene; Drug Combinations; Drug Utilization; Humans; Pain | 1996 |
The effect of acetaminophen, ibuprofen, and misoprostol on prostaglandin E2 synthesis and the degree and rate of orthodontic tooth movement.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Inflammatory Agents, No | 1996 |
Mothers' attitudes and behavior toward medicating children's pain.
Topics: Acetaminophen; Adult; Attitude to Health; Child; Child, Preschool; Female; Humans; Maternal Behavior | 1996 |
Naloxone-reversible antinociception by paracetamol in the rat.
Topics: Acetaminophen; Animals; Cerebral Cortex; Formaldehyde; Hot Temperature; Ketanserin; Kinetics; Male; | 1997 |
Acetaminophen in the management of background pain in children post-burn.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Burns; Child; Child, Preschool; Humans; Pain; Retrospective | 1997 |
Hair opiates during pain treatment.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Codeine; Gas Chromatography-Mass Spectrometry; Hair; Humans | 1997 |
Neonatal abstinence syndrome due to codeine.
Topics: Acetaminophen; Adult; Codeine; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome; | 1997 |
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non- | 1997 |
[The physiological properties of the action of a new analgesic and antipyretic preparation].
Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroid | 1997 |
[The use of the preparation Solpadeine in dental practice].
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caff | 1997 |
[Pancreatic pain in cholecystectomized patients after taking paracetamol and codeine].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cholecystectomy; Codeine; Headache; Hum | 1997 |
Management of sickle cell disease. Non-addictive analgesics can be as effective as morphine and pethidine.
Topics: Acetaminophen; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Combi | 1998 |
Pain relief in children. Doing the simple things better.
Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Humans; Pain; Pain Measurement | 1998 |
Co-proxamol is effective in chronic pain.
Topics: Acetaminophen; Chronic Disease; Dextropropoxyphene; Drug Combinations; Humans; Pain; Treatment Outco | 1998 |
Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
Topics: Abdomen; Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 1998 |
North of England evidence based guideline development project: summary guideline for non-steroidal anti-inflammatory drugs versus basic analgesia in treating the pain of degenerative arthritis. The North of England Non-Steroidal Anti-Inflammatory Drug Gui
Topics: Acetaminophen; Activities of Daily Living; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Codei | 1998 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
AGS clinical practice guidelines: the management of chronic pain in older persons.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age | 1998 |
Tramadol or hydrocodone-acetaminophen for acute musculoskeletal pain?
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Opioid; Double-Blind Method; Drug | 1998 |
Analgesics in the management of chronic pain. Part two: Step I analgesic drug therapy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; H | 1998 |
Perioperative pharmacodynamics of acetaminophen analgesia in children.
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesia; Analgesics, Non-Narcotic; Ch | 1999 |
Tramadol: new preparation. Capsules: central analgesic; step 2 on the WHO scale.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Doub | 1998 |
Who gives pain relief to children?
Topics: Acetaminophen; Adolescent; Analgesia; Analgesics; Child; Child, Preschool; Emergency Medical Service | 1999 |
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dinoprostone; Male; Pain; Rats; Rats, Sprague-Dawl | 1999 |
[Chronic pain during dialysis. Pharmacologic therapy and its costs].
Topics: Acetaminophen; Analgesics; Arthralgia; Buprenorphine; Chronic Disease; Codeine; Disability Evaluatio | 1999 |
Analgesia in soft-tissue injury: current practice in Auckland is not supported by the available evidence.
Topics: Acetaminophen; Adult; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 1999 |
[The association of patient with painful ophthalmoplegia and cluster headache: do they have a single physiopathological mechanism?].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents; Cluste | 1999 |
Parental guidance suggested. Pediatric fever and pain relief require expert input.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Education; Fever; Humans; Ibuprofe | 1999 |
Novalgin in pain and fever.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Dipyrone; Female; Humans; Infant; | 1999 |
Profound hearing loss associated with hydrocodone/acetaminophen abuse.
Topics: Acetaminophen; Adult; Analgesics; Cochlear Implantation; Disease Progression; Drug Combinations; Fem | 2000 |
An audit of patient perception compared with medical and nursing staff estimation of pain during burn dressing changes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Non-Narcotic; Ana | 2000 |
Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dipyrone; Disinfectants; Dose-Re | 2000 |
Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Ede | 2000 |
Drugs for pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2000 |
Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Cultur | 2000 |
NCCN Practice Guidelines for Cancer Pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Neoplasms; Pain; Pain Measureme | 2000 |
Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Area Under Curve; Drug Therapy, Co | 2001 |
[Eccrine neutrophilic hidradenitis: idiopathic plantar form in children].
Topics: Acetaminophen; Activities of Daily Living; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory A | 2001 |
Who's feeling no pain?
Topics: Acetaminophen; Analgesics; Drug Combinations; Humans; Hydrocodone; Pain; Substance-Related Disorders | 2001 |
[Prevalence and management of pain in a hospital: a cross-sectional study].
Topics: Acetaminophen; Adult; Age Factors; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; A | 2001 |
The position of paracetamol in the world of analgesics.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nonprescri | 2000 |
The effect of a paracetamol and morphine combination on dynorphin A levels in the rat brain.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Drug Combin | 2001 |
[Liver and renal tolerance to paracetamol: 3 g or 4 g per day?].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2001 |
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid | 2001 |
Drug-seeking behavior--a differential approach.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Pain; Pain Management | 2001 |
The influence of divalent cations on the analgesic effect of opioid and non-opioid drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blood Pressure; Butorphanol; C | 2001 |
Codeine for child pain: new preparation. Helpful in some cases.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1999 |
Pain management. Medication update.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclooxygenase Inhibitors | 2001 |
Pain experience during transvaginal aspiration of immature oocytes.
Topics: Acetaminophen; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-An | 2001 |
Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Behavior, Animal; Cyclooxygenase Inhibito | 2001 |
Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital.
Topics: Acetaminophen; Analgesics, Opioid; Australia; Cathartics; Chemotherapy, Adjuvant; Computer Simulatio | 2001 |
Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Barbiturates; Caffeine; Carrageenan; Dose-Response | 2001 |
[Step-children of pain therapy. The newborn suffer particularly severely].
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Bupiva | 2001 |
[Minimally invasive surgery for diverticula of the thoracic esophagus. Results in 11 patients].
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesia; Diverticulum, Esophageal; Female; Humans; Laparos | 2001 |
New, non-NSAID alternative.
Topics: Acetaminophen; Acute Disease; Analgesics; Drug Approval; Drug Combinations; Humans; Pain; Tramadol; | 2002 |
[Effective not only in rheumatism and arthrosis. Rofecoxib fights also acute pain].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Benzimidazoles; Escherichia coli; Female; Guinea Pi | 2002 |
[Clinical studies with the new two-component analgesic Panagesic].
Topics: Acetaminophen; Adult; Aged; Analgesics; Burns; Drug Combinations; Drug Evaluation; Female; Fractures | 1979 |
Inflammation and the role of endogenous pain-producing substances.
Topics: Acetaminophen; Anti-Inflammatory Agents; Bradykinin; Histamine; Humans; Inflammation; Kallikreins; K | 1978 |
Pain control in endodontics.
Topics: Acetaminophen; Analgesics; Aspirin; Cellulitis; Codeine; Dextropropoxyphene; Humans; Nausea; Pain; P | 1979 |
Simple analgesics in rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Synergism; Human | 1977 |
Analgesic requirements after orthognathic surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Female; Humans; Male; Malocclusion; Meperidin | 1976 |
Diagnosis of hypothyroidism after a surgical complication.
Topics: Acetaminophen; Adult; Humans; Hypothyroidism; Male; Oral Hemorrhage; Pain; Postoperative Complicatio | 1975 |
Analgesics--the choice.
Topics: Acetaminophen; Aspirin; Gastrointestinal Hemorrhage; Humans; Pain | 1976 |
Letter: Acetaminophen.
Topics: Acetaminophen; Child; Humans; Pain; Rheumatic Fever | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Comparison of fixed interval and visual analogue scales for rating chronic pain.
Topics: Acetaminophen; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Male; | 1975 |
Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents.
Topics: Acetaminophen; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carragee | 1976 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
Survey of pain management therapy provided for children with sickle cell disease.
Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Administratio | 1992 |
Reaction time in cancer patients receiving peripherally acting analgesics alone or in combination with opioids.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Hum | 1992 |
Pharmacokinetic/pharmacodynamic analysis of the interaction between acetaminophen and caffeine.
Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Chromatography, High Pressure Liquid; Drug S | 1992 |
Pain during burn dressing change in children: relationship to burn area, depth and analgesic regimens.
Topics: Acetaminophen; Adolescent; Bandages; Burns; Child; Female; Humans; Male; Morphine; Oxycodone; Pain; | 1991 |
Effects of paracetamol and aspirin on neural activity of joint mechanonociceptors in adjuvant arthritis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; E | 1991 |
NSAIDs, musculoskeletal disorders and gastrointestinal adverse effects.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Gastrointestinal Hemorr | 1991 |
Nonnarcotic analgesics and tricyclic antidepressants for the treatment of chronic nonmalignant pain.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic | 1991 |
Treatment of watery mouth in lambs.
Topics: Acetaminophen; Animals; Escherichia coli Infections; Pain; Sheep; Sheep Diseases | 1991 |
The underutilization of oxycodone.
Topics: Acetaminophen; Adult; Anus Neoplasms; Drug Combinations; Female; Humans; Oxycodone; Pain | 1991 |
Advertising acyclovir.
Topics: Acetaminophen; Acyclovir; Advertising; Herpes Zoster; Humans; Pain | 1990 |
Pharmacologic agents for pain management.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Narcotics; Pain | 1991 |
Women to have more say in births?
Topics: Acetaminophen; Aspirin; Codeine; Female; Humans; Pain; Pregnancy; Pregnancy Complications | 1990 |
Pharmaco-toxicological effects of acetaminophen in rodents. Battery of tests to screen potential analgesic acetaminophen derivatives.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-St | 1990 |
Simple analgesics preferable to NSAIDs for the elderly.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pa | 1990 |
Acetaminophen hepatotoxicity in the alcoholic.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr | 1990 |
Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin.
Topics: Acetaminophen; Animals; Aspirin; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Inje | 1985 |
Drug management of pain in cancer patients.
Topics: Acetaminophen; Humans; Neoplasms; Pain; Palliative Care | 1985 |
Ibuprofen vs acetaminophen in children.
Topics: Acetaminophen; Child; Drug Overdose; Fever; Humans; Ibuprofen; Pain; Suspensions | 1989 |
Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Bone Marrow Transplantation; Codeine; Drug Administrat | 1989 |
The use of methotrimeprazine (Levoprome) in a patient sensitive to opioids and possible bowel shutdown.
Topics: Acetaminophen; Adenocarcinoma; Female; Humans; Intestinal Obstruction; Lung Neoplasms; Methotrimepra | 1989 |
[Paracetamol].
Topics: Acetaminophen; Fever; Humans; Pain | 1989 |
Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model.
Topics: Acetaminophen; Animals; Arthritis; Arthritis, Experimental; Aspirin; Male; Pain; Rats; Rats, Inbred | 1989 |
Pain-relief in sickle cell crisis.
Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Bone and Bones; Child; Humans; Pain; Recurrence | 1986 |
Analgesics in the management of acute pain.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dru | 1986 |
Current modalities in arthritic diseases.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthrit | 1987 |
[3-step pharmacologic treatment of pain in cancer. Preliminary experience in Chile].
Topics: Acetaminophen; Adult; Analgesics; Chile; Codeine; Drug Administration Schedule; Female; Follow-Up St | 1988 |
FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Disease Mode | 1988 |
Nonnarcotic analgesic abuse. A common biopsychosocial problem.
Topics: Acetaminophen; Aged; Analgesics; Behavior Therapy; Female; Humans; Marriage; Multiple Sclerosis; Pai | 1988 |
[Drug treatment for pain].
Topics: Acetaminophen; Analgesics; Anesthetics, Local; Aspirin; Humans; Kinetics; Pain; Psychotropic Drugs | 1986 |
Central analgesic effect of paracetamol manifested by depression of nociceptive activity in thalamic neurones of the rat.
Topics: Acetaminophen; Analgesics; Animals; Drug Interactions; Evoked Potentials; Female; Male; Naloxone; Pa | 1987 |
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphin | 1987 |
[Therapy of pain caused by gastrointestinal tumors].
Topics: Acetaminophen; Aspirin; Bone Diseases; Dipyrone; Humans; Injections, Epidural; Narcotics; Neoplasms; | 1987 |
[Analgesics in general practice].
Topics: Acetaminophen; Analgesics; Dipyrone; Dose-Response Relationship, Drug; Drug Combinations; Humans; Pa | 1986 |
The effect of acetaminophen administration on its disposition and body stores of sulphate.
Topics: Acetaminophen; Adolescent; Adult; Female; Humans; Male; Pain; Sulfates; Time Factors | 1986 |
[Paracetamol activity against pain provoked by different stimuli. Influence of aminergic mechanisms].
Topics: Acetaminophen; Animals; Biogenic Amines; Male; Pain; Rats | 1986 |
Orphenadrine citrate increases and prolongs the antinociceptive effects of paracetamol in mice.
Topics: Acetaminophen; Animals; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Mal | 1986 |
[Analgesics in dental practice].
Topics: Acetaminophen; Analgesics; Dental Care; Drug Combinations; Humans; Pain; Pain, Postoperative; Pyrazo | 1985 |
Use of simple analgesics in rheumatoid arthritis.
Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis, Rheumatoid; Dextropropoxyphene; Drug Combinations | 1985 |
Differentiation of peripheral and central effects of analgesic drugs.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diclofenac; Male; Morphine; Pain; Rabbits; Reflex | 1985 |
[Evaluation of the analgesic activity of a preconstituted combination of acetylsalicylic acid, paracetamol and caffeine].
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Drug Combinations; Drug Evaluation; Female; Hum | 1985 |
Pain in haemophilia.
Topics: Acetaminophen; Analgesics; Hemophilia A; Humans; Indomethacin; Male; Meperidine; Oxyphenbutazone; Pa | 1973 |
Pain in haemophilia.
Topics: Acetaminophen; Analgesics; Aspirin; Codeine; Cryotherapy; Gastrointestinal Hemorrhage; Headache; Hem | 1973 |
Control of pain by drugs.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Aspirin; Humans; Morphine; Pain; Tranquilizing Agents | 1974 |
[Clinical observations and analgesic properties of the association of paracetamol and phenylbutazone].
Topics: Acetaminophen; Back Pain; Contusions; Ear Diseases; Headache; Humans; Joint Diseases; Muscular Disea | 1966 |
A comparison of propoxyphene HCl (Darvon) and an analgesic mixture (Percogesic) in pain relief after gingivectomy.
Topics: Acetaminophen; Adult; Analgesics; Atropine; Caffeine; Dextropropoxyphene; Female; Gingivectomy; Hist | 1967 |
[Clinical study of a new antalgic: Propofan].
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His | 1972 |
[Clinical evaluation of a new analgesic. (Study of 1000 cases)].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Child; Evaluation Studies as Topic; Female; Huma | 1972 |
[Clinical experiences with a new analgetic-antipyretic drug combination in pediatrics].
Topics: Acetaminophen; Child; Child, Preschool; Dextropropoxyphene; Drug Combinations; Fever; Humans; Infant | 1973 |
Arthralgia and myalgia in mumps.
Topics: Acetaminophen; Adult; Arthritis; Blood Cell Count; Fever; Hematocrit; Hemoglobins; Humans; Male; Mum | 1973 |
Effects of caffeine on the absorption and analgesic efficacy of paracetamol in rats.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Caffeine; Depression, Chemical; Dose-Respo | 1973 |
[Oluprin--a clinical study of a new analgesic].
Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Proteins; Child; Evaluation Studies as Topic; Female; | 1970 |
Analgetic drugs--the mild analgetics.
Topics: Acetaminophen; Acetanilides; Administration, Oral; Analgesics; Aspirin; Codeine; Dextropropoxyphene; | 1972 |
[Practical experience with Neuramag sine].
Topics: Acetaminophen; Adult; Aged; Aspirin; Caffeine; Chemical Phenomena; Chemistry; Drug Combinations; Fem | 1972 |
[Study of a new combination of analgesic substances].
Topics: Acetaminophen; Adult; Caffeine; Female; Humans; Male; Pain; Salicylamides | 1965 |
[Analgesic effect of the compound paracetamol-phenylbutazone].
Topics: Acetaminophen; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Pain; Phenylbutazone | 1967 |
[Parazolidin R in odontogenic pain].
Topics: Acetaminophen; Alveolectomy; Humans; Pain; Periapical Abscess; Periodontitis; Phenylbutazone; Tooth | 1968 |
[Pain treatment with Oluprin].
Topics: Acetaminophen; Humans; Pain; Phenylbutazone | 1969 |
[Experiences with the new analgesic Oluprin].
Topics: Acetaminophen; Analgesics; Humans; Pain; Phenylbutazone | 1970 |
Paracetamol overdose.
Topics: Acetaminophen; Adult; Blood Sedimentation; Cell Migration Inhibition; Dysmenorrhea; Erythema; Female | 1971 |
A device for measuring the threshold of pain in man.
Topics: Acetaminophen; Achilles Tendon; Analgesia; Aspirin; Female; Humans; Male; Methods; Pain; Pharmacolog | 1968 |
The analgetic properties of m-trifluoromethyl acetanilide.
Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperatur | 1968 |
[Requirements for an analgesic therapy in a military medical practice].
Topics: Acetaminophen; Analgesics; Germany, West; Humans; Military Medicine; Pain | 1965 |
[On treatment of the "pain" symptom in obstetric and gynecologic pathology].
Topics: Acetaminophen; Female; Genital Diseases, Female; Humans; Muscles; Pain | 1965 |
Treatment of insomnia complicated by pain using a chloral hydrate paracetamol complex.
Topics: Acetaminophen; Chloral Hydrate; Drug Synergism; Humans; Pain; Sleep Initiation and Maintenance Disor | 1966 |