Page last updated: 2024-10-22

acetaminophen and Abortion, Tubal

acetaminophen has been researched along with Abortion, Tubal in 4 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
" Only one study found evidence of an effect between interventions on pain score: a prophylactic dose of ibuprofen 1600 mg likely reduces the pain score when compared to a dose of paracetamol 2000 mg (mean difference (MD) 2."5.22Pain management for medical abortion before 14 weeks' gestation. ( Cameron, S; Morroni, C; Reynolds-Wright, JJ; Woldetsadik, MA, 2022)
"We estimated the proportion of miscarriage to be almost doubled, whereas there was no increased risk of congenital abnormalities or prematurity in women exposed to a drug overdose compared with the background population."1.31Pregnancy outcome after suicide attempt by drug use: a Danish population-based study. ( Flint, C; Larsen, H; Nielsen, GL; Olsen, J; Sørensen, HT, 2002)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Reynolds-Wright, JJ1
Woldetsadik, MA1
Morroni, C1
Cameron, S1
Li, DK1
Liu, L1
Odouli, R1
Flint, C1
Larsen, H1
Nielsen, GL1
Olsen, J1
Sørensen, HT1
Riggs, BS1
Bronstein, AC1
Kulig, K1
Archer, PG1
Rumack, BH1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prophylactic Pregabalin to Decrease Pain During Medical Abortion: a Randomized Controlled Trial[NCT02782169]Phase 4110 participants (Actual)Interventional2015-06-30Completed
PAIN CONTROL IN FIRST TRIMESTER MEDICAL ABORTION: A Randomized Trial[NCT01457521]Phase 4250 participants (Actual)Interventional2011-10-31Completed
The Effect of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion: A Double-blind Randomized Placebo Controlled Study[NCT00997074]Phase 361 participants (Actual)Interventional2009-10-31Completed
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]11,976 participants (Actual)Interventional2016-03-23Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maximum Pain Score Over Study Period

reported on an 11-point numerical rating scale (NRS 0-10) where 0 indicates no pain and 10 indicates the most severe pain (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

Interventionunits on a scale (Mean)
Pregabalin5.0
Placebo5.5

Number of Ibuprofen 800mg Tablets Used

summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

Interventiontablets (Median)
Pregabalin1
Placebo2

Number of Oxycodone/Acetominophen Tablets (5/325mg) Used

summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

Interventiontablets (Median)
Pregabalin0
Placebo0.5

Number of Participants Ever Experiencing Different Symptoms During Abortion

A participant was included once if they ever reported a symptom during the 72 hour study period, not reflective of how long the symptom lasted. These were all commonly reported side effects during previous research on medication abortions and commonly reported side effects of pregabalin, so they were not included as adverse events. (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)

,
Interventionparticipants (Number)
NauseaVomitingSleepinessDizzinessHeadacheBlurred VisionDiarrheaConstipationDry Mouth
Placebo42303926177291525
Pregabalin43284745281528622

11-point Visual Analog Scale for Pain

Participant pain was assessed using an 11-point Visual Analog Scale for Pain. Scores ranged from 0 (no pain) to 10 (worst pain possible) (NCT01457521)
Timeframe: 1-2 weeks

Interventionunits on a scale (Mean)
Prophylactic7.1
Therapeutic7.3

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm189
Placebo Arm230

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

- Birth weight <2500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm1078
Placebo Arm1153

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

- Birth weight <1500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm78
Placebo Arm101

Fetal Outcome 4 - Incidence of Fetal Loss

- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm303
Placebo Arm353

Fetal Outcome 5 - Incidence of Spontaneous Abortion

- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm134
Placebo Arm152

Fetal Outcome 6 - Incidence of All Stillbirth

- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm141
Placebo Arm166

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm42
Placebo Arm30

Incidence of Hypertensive Disorders of Pregnancy

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

InterventionParticipants (Count of Participants)
Intervention Arm352
Placebo Arm325

Incidence of Perinatal Mortality

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm264
Placebo Arm309

Incidence of Preterm Birth

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm668
Placebo Arm754

Incidence of Small for Gestational Age (SGA)

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm1506
Placebo Arm1564

Maternal Outcome 1 - Incidence of Vaginal Bleeding

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm214
Placebo Arm246

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm26
Placebo Arm25

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm54
Placebo Arm43

Maternal Outcome 4 - Incidence of Maternal Mortality

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm9
Placebo Arm12

Maternal Outcome 5 - Incidence of Late Abortion

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm23
Placebo Arm30

Maternal Outcome 6 - Change in Maternal Hemoglobin

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

InterventionParticipants (Count of Participants)
Intervention Arm290
Placebo Arm333

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm8
Placebo Arm21

Reviews

1 review available for acetaminophen and Abortion, Tubal

ArticleYear
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022
Pain management for medical abortion before 14 weeks' gestation.
    The Cochrane database of systematic reviews, 2022, 05-13, Volume: 5

    Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi

2022

Other Studies

3 other studies available for acetaminophen and Abortion, Tubal

ArticleYear
Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population based cohort study.
    BMJ (Clinical research ed.), 2003, Aug-16, Volume: 327, Issue:7411

    Topics: Abortion, Spontaneous; Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studi

2003
Pregnancy outcome after suicide attempt by drug use: a Danish population-based study.
    Acta obstetricia et gynecologica Scandinavica, 2002, Volume: 81, Issue:6

    Topics: Abortion, Spontaneous; Acetaminophen; Adolescent; Adult; Aspirin; Child; Child, Preschool; Denmark;

2002
Acute acetaminophen overdose during pregnancy.
    Obstetrics and gynecology, 1989, Volume: 74, Issue:2

    Topics: Abortion, Spontaneous; Acetaminophen; Acetylcysteine; Acute Disease; Adult; Female; Fetal Death; Hum

1989