acetaminophen has been researched along with Abnormalities, Drug-Induced in 34 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen is commonly used during pregnancy." | 8.86 | A review of the literature on the effects of acetaminophen on pregnancy outcome. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010) |
| "Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child." | 8.76 | Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ( Collins, E, 1981) |
| "To investigate whether exposure during the first trimester of pregnancy to single-ingredient acetaminophen increases the risk of major birth defects." | 7.76 | Acetaminophen use in pregnancy and risk of birth defects: findings from the National Birth Defects Prevention Study. ( Botto, LD; Feldkamp, ML; Krikov, S; Meyer, RE, 2010) |
| "We selected 88,142 pregnant women and their liveborn singletons from the Danish National Birth Cohort who had information on acetaminophen use during the first trimester of pregnancy." | 7.74 | Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. ( Czeizel, AE; Horváth-Puhó, E; Kogevinas, M; Morales, M; Nørgård, B; Olsen, J; Rebordosa, C; Sørensen, HT; Vilstrup, H, 2008) |
| "We studied the association between acetaminophen exposure during pregnancy and the prevalence of congenital abnormalities and fetal growth." | 7.70 | Fetal growth and adverse birth outcomes in women receiving prescriptions for acetaminophen during pregnancy. EuroMap Study Group. ( Andersen, L; Barrett, D; Nielsen, GL; Olsen, J; Sørensen, HT; Thulstrup, AM; Vilstrup, H, 1999) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 7.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "(1) Gastroschisis is a severe defect in the closure of the abdominal wall in newborns." | 5.32 | Gastroschisis and pseudoephedrine during pregnancy. ( , 2004) |
| " For a long time, acetaminophen was considered as a relatively safe antipyretic and analgesic drug during pregnancy." | 4.88 | Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. ( Burdan, F; Starosławska, E; Szumiło, J, 2012) |
| "Acetaminophen is commonly used during pregnancy." | 4.86 | A review of the literature on the effects of acetaminophen on pregnancy outcome. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010) |
| "Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child." | 4.76 | Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ( Collins, E, 1981) |
| "Compared to acetaminophen, mothers reporting NSAIDs were significantly more likely to have offspring with gastroschisis, hypospadias, cleft palate, cleft lip with cleft palate, cleft lip without cleft palate, anencephaly, spina bifida, hypoplastic left heart syndrome, pulmonary valve stenosis, and tetralogy of Fallot (aOR range, 1." | 3.85 | Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997-2011. ( Ailes, EC; Anderka, M; Broussard, CS; Feldkamp, ML; Gilboa, SM; Interrante, JD; Lind, JN; Taylor, LG; Trinidad, J; Werler, MM, 2017) |
| "To investigate whether exposure during the first trimester of pregnancy to single-ingredient acetaminophen increases the risk of major birth defects." | 3.76 | Acetaminophen use in pregnancy and risk of birth defects: findings from the National Birth Defects Prevention Study. ( Botto, LD; Feldkamp, ML; Krikov, S; Meyer, RE, 2010) |
| "We selected 88,142 pregnant women and their liveborn singletons from the Danish National Birth Cohort who had information on acetaminophen use during the first trimester of pregnancy." | 3.74 | Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. ( Czeizel, AE; Horváth-Puhó, E; Kogevinas, M; Morales, M; Nørgård, B; Olsen, J; Rebordosa, C; Sørensen, HT; Vilstrup, H, 2008) |
| "We studied the association between acetaminophen exposure during pregnancy and the prevalence of congenital abnormalities and fetal growth." | 3.70 | Fetal growth and adverse birth outcomes in women receiving prescriptions for acetaminophen during pregnancy. EuroMap Study Group. ( Andersen, L; Barrett, D; Nielsen, GL; Olsen, J; Sørensen, HT; Thulstrup, AM; Vilstrup, H, 1999) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 3.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "Migraine is a typical "women's disease": the fluctuations of sex hormones, in particular estrogens, during woman's reproductive life show a direct and major influence on migraine course." | 2.42 | [Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies]. ( Airola, G; Allais, G; Benedetto, C; Bosio, A; Ciochetto, D; De Lorenzo, C; Mana, O; Quirico, PE; Terzi, MG, 2003) |
| "(1) Gastroschisis is a severe defect in the closure of the abdominal wall in newborns." | 1.32 | Gastroschisis and pseudoephedrine during pregnancy. ( , 2004) |
| "Acetaminophen (APAP) was evaluated for reproductive toxicity in Swiss CD-1 mice using a continuous breeding protocol." | 1.28 | Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol. ( Lamb, JC; Lawton, AD; Reel, JR, 1992) |
| "Acetaminophen pretreatment caused a threefold increase in phenytoin-induced fetal cleft palates without increasing resorptions." | 1.27 | Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen. ( Lum, JT; Wells, PG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (29.41) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Interrante, JD | 1 |
| Ailes, EC | 1 |
| Lind, JN | 1 |
| Anderka, M | 1 |
| Feldkamp, ML | 2 |
| Werler, MM | 1 |
| Taylor, LG | 1 |
| Trinidad, J | 1 |
| Gilboa, SM | 1 |
| Broussard, CS | 1 |
| Kiernan, E | 1 |
| Jones, KL | 1 |
| Mazaud-Guittot, S | 1 |
| Nicolas Nicolaz, C | 1 |
| Desdoits-Lethimonier, C | 1 |
| Coiffec, I | 1 |
| Ben Maamar, M | 1 |
| Balaguer, P | 1 |
| Kristensen, DM | 1 |
| Chevrier, C | 1 |
| Lavoué, V | 1 |
| Poulain, P | 1 |
| Dejucq-Rainsford, N | 1 |
| Jégou, B | 1 |
| Fatori Popovic, S | 1 |
| Lübbers, HT | 1 |
| von Mandach, U | 1 |
| Hultzsch, S | 1 |
| Schaefer, C | 1 |
| Meyer, RE | 1 |
| Krikov, S | 1 |
| Botto, LD | 1 |
| Peng, HC | 1 |
| Wang, YH | 1 |
| Wen, CC | 1 |
| Wang, WH | 1 |
| Cheng, CC | 1 |
| Chen, YH | 1 |
| Scialli, AR | 1 |
| Ang, R | 1 |
| Breitmeyer, J | 1 |
| Royal, MA | 1 |
| Burdan, F | 3 |
| Starosławska, E | 1 |
| Szumiło, J | 1 |
| Poletta, FA | 1 |
| López Camelo, JS | 1 |
| Gili, JA | 1 |
| Leoncini, E | 1 |
| Castilla, EE | 1 |
| Mastroiacovo, P | 1 |
| HARLEY, JD | 1 |
| FARRAR, JF | 1 |
| GRAY, JB | 1 |
| DUNLOP, IC | 1 |
| Allais, G | 1 |
| Bosio, A | 1 |
| Mana, O | 1 |
| Airola, G | 1 |
| Ciochetto, D | 1 |
| Terzi, MG | 1 |
| De Lorenzo, C | 1 |
| Quirico, PE | 1 |
| Benedetto, C | 1 |
| Rebordosa, C | 1 |
| Kogevinas, M | 1 |
| Horváth-Puhó, E | 1 |
| Nørgård, B | 1 |
| Morales, M | 1 |
| Czeizel, AE | 1 |
| Vilstrup, H | 2 |
| Sørensen, HT | 2 |
| Olsen, J | 2 |
| Adjei, AA | 1 |
| Gaedigk, A | 1 |
| Simon, SD | 1 |
| Weinshilboum, RM | 1 |
| Leeder, JS | 1 |
| Reid, JD | 1 |
| Gabbe, SG | 1 |
| Golden, NL | 1 |
| King, KC | 1 |
| Sokol, RJ | 1 |
| Collins, E | 1 |
| Rudolph, AM | 1 |
| Park, BK | 1 |
| Pirmohamed, M | 1 |
| Kitteringham, NR | 1 |
| Thulstrup, AM | 1 |
| Nielsen, GL | 1 |
| Andersen, L | 1 |
| Barrett, D | 1 |
| Laub, DN | 1 |
| Elmagbari, NO | 1 |
| Elmagbari, NM | 1 |
| Hausburg, MA | 1 |
| Gardiner, CS | 1 |
| Nebert, DW | 1 |
| Thorgeirsson, SS | 1 |
| Lambert, GH | 1 |
| Fort, DJ | 1 |
| Rayburn, JR | 1 |
| Bantle, JA | 1 |
| Reel, JR | 1 |
| Lawton, AD | 1 |
| Lamb, JC | 1 |
| Zheng, J | 1 |
| Zhang, S | 1 |
| McElhatton, PR | 1 |
| Sullivan, FM | 1 |
| Volans, GN | 1 |
| Fitzpatrick, R | 1 |
| Stark, KL | 3 |
| Lee, QP | 1 |
| Namkung, MJ | 1 |
| Harris, C | 3 |
| Juchau, MR | 3 |
| Luchtel, DL | 1 |
| Lum, JT | 1 |
| Wells, PG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728] | Phase 3 | 19 participants (Actual) | Interventional | 2013-01-01 | Completed | ||
| The Copenhagen Analgesic Study[NCT04369222] | 600 participants (Anticipated) | Observational | 2020-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for acetaminophen and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Medications that Cause Fetal Anomalies and Possible Prevention Strategies.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Analg | 2019 |
[Analgesic drugs during pregnancy].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acute Pain; Analgesics; Analgesics, Opioid; Anticonvulsa | 2016 |
A review of the literature on the effects of acetaminophen on pregnancy outcome.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Female; | 2010 |
Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Cyclooxygenase Inhibi | 2012 |
[Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acupuncture Points; Acupuncture Therapy; Adult; Analgesi | 2003 |
Drug therapy in autoimmune diseases.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adrenal Cortex Hormones; Autoimmune Diseases; Azathiopri | 1983 |
Maternal and fetal effects of acetaminophen and salicylates in pregnancy.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Chemical and Drug Induced Liver I | 1981 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1995 |
[Paracetamol prenatal toxicity].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Birth Weight; Body He | 1999 |
Paracetamol poisoning in pregnancy: an analysis of the outcomes of cases referred to the Teratology Information Service of the National Poisons Information Service.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Female; Follow-Up Studies; Humans; Infant, Newborn; Info | 1990 |
24 other studies available for acetaminophen and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997-2011.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, | 2017 |
Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Acetaminophen; Analgesics, Non-Narcotic; Androgens; | 2013 |
Pregnancy and lactation period: Which local anesthetics and analgesics?
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics; Anesthetics, Local; Breast Feeding; Carticai | 2016 |
Acetaminophen use in pregnancy and risk of birth defects: findings from the National Birth Defects Prevention Study.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adult; Analgesics, Non-Narcotic; Female; Humans; Odds Ra | 2010 |
Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Cyclooxygenase 2; Dos | 2010 |
Methodological approaches to evaluate teratogenic risk using birth defect registries: advantages and disadvantages.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Anticonvulsants; Female; Humans; Infant, Newborn; Insuli | 2012 |
AROMATIC DRUGS AND CONGENITAL CATARACTS.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acetazolamide; Anti-Bacterial Agents; Cardiovascular Age | 1964 |
Gastroschisis and pseudoephedrine during pregnancy.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adrenergic Agents; Case-Control Studies; Ephedrine; Fema | 2004 |
Acetaminophen use during pregnancy: effects on risk for congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Cohort Studies; Denmark; Femal | 2008 |
Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Humans; Liver; Pharmacogenetics; Sulfates; Sulfotransfer | 2008 |
Effects of selected OTC medications on the unborn and newborn.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Aspirin; Female; Fetus; Histamine H1 Antagonists; Humans | 1983 |
Propoxyphene and acetaminophen. Possible effects on the fetus.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetaminophen; Dextropropoxyphene; Drug Therap | 1982 |
Effects of aspirin and acetaminophen in pregnancy and in the newborn.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Aspirin; Blood Platelets; Female; Fetus; Humans | 1981 |
Fetal growth and adverse birth outcomes in women receiving prescriptions for acetaminophen during pregnancy. EuroMap Study Group.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adolescent; Adult; Cohort Studies; Confidence Intervals; | 1999 |
Effects of acetaminophen on preimplantation embryo glutathione concentration and development in vivo and in vitro.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Blastocyst; Chromatog | 2000 |
Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthraquinones; Bone | 2000 |
Genetic aspects of toxicity during development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Acetaminophen; Alleles; Animals; Aryl | 1976 |
Evaluation of acetaminophen-induced developmental toxicity using FETAX.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Biological Assay; Biotransformation; Carbon Mon | 1992 |
Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Birth Weight; Body Weight; Breeding; Dose-Respo | 1992 |
Case of atypical cyclopia.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Eye Abnormalities; Female; Humans; Infant, Newborn; Preg | 1991 |
Dysmorphogenesis elicited by microinjected acetaminophen analogs and metabolites in rat embryos cultured in vitro.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Benzoquinones; Embryo, Mammalian; Female; Imine | 1990 |
Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Acetaminophen; Animals; Biological Availability; | 1989 |
Modulation of the embryotoxicity and cytotoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Acetaminophen; Acetylation; Animals; Cell Surviv | 1989 |
Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Brain; Cleft Palate; Drug Synergism; Embryo Los | 1986 |