acetaminophen has been researched along with Abnormalities, Autosome in 20 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In reliable, well-controlled test systems, clastogenic effects were only observed in unstable, p53-deficient cell systems or at toxic and/or excessively high concentrations that adversely affect cellular processes (e." | 2.72 | A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential. ( Deore, M; Eichenbaum, G; Jacobson-Kram, D; Jaeschke, H; Kirkland, D; Kovochich, M; Miller, JV; Monnot, AD; More, SL; Murray, FJ; Pitchaiyan, SK; Unice, K, 2021) |
| "No significant increases in structural chromosome aberrations (CA) were found either when the paracetamol group (male, female or both) post-dosing values were compared with pre-dosing values, or when treated groups at any sampling time were compared with the placebo groups." | 2.67 | Normal chromosomal aberration frequencies in peripheral lymphocytes of healthy human volunteers exposed to a maximum daily dose of paracetamol in a double blind trial. ( Baumeister, M; Dresp, JH; Gerloff, C; Gocke, E; Kirkland, DJ; Marshall, RR, 1992) |
| " None of these metabolites revealed a splenotoxic potential comparable to that of aniline in studies with repeated or long-term administration to rats." | 2.43 | Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats. ( Bomhard, EM; Herbold, BA, 2005) |
| " Studies of the relationship between genotoxicity and toxic effects in the rat (induction of micronuclei in rat bone marrow including dose-response relationship, biotransformation of paracetamol at different dosages, concomitant toxicity and biochemical markers) have recently been completed." | 2.39 | Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view. ( Bergman, K; Müller, L; Teigen, SW, 1996) |
| " The trend tests for the evidence of dose-response effects for both SCE and CA were significant." | 1.28 | Sister-chromatid exchange and chromosome aberrations induced by paracetamol in vivo in bone-marrow cells of mice. ( Giri, AK; Khan, KA; Sivam, SS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diab, KA | 1 |
| Fahmy, MA | 1 |
| Hassan, EM | 1 |
| Hassan, ZM | 1 |
| Omara, EA | 1 |
| Abdel-Samie, NS | 1 |
| Kirkland, D | 1 |
| Kovochich, M | 1 |
| More, SL | 1 |
| Murray, FJ | 1 |
| Monnot, AD | 1 |
| Miller, JV | 1 |
| Jaeschke, H | 1 |
| Jacobson-Kram, D | 1 |
| Deore, M | 1 |
| Pitchaiyan, SK | 1 |
| Unice, K | 1 |
| Eichenbaum, G | 1 |
| Bomhard, EM | 1 |
| Herbold, BA | 1 |
| Ibrulj, S | 1 |
| Rahmanovic, A | 1 |
| Haveric, S | 1 |
| Haveric, A | 1 |
| Pasic, AD | 1 |
| Sasaki, M | 2 |
| Yoshida, S | 1 |
| Hiraga, K | 1 |
| Watanabe, M | 1 |
| Tsuruzaki, T | 1 |
| Watanabe, G | 1 |
| Yamamoto, M | 1 |
| Laxminarayana, D | 1 |
| Murthy, DK | 1 |
| Subramanyam, S | 1 |
| Bergman, K | 1 |
| Müller, L | 2 |
| Teigen, SW | 1 |
| Rompelberg, CJ | 1 |
| Vogels, JT | 1 |
| de Vogel, N | 1 |
| Bruijntjes-Rozier, GC | 1 |
| Stenhuis, WH | 1 |
| Bogaards, JJ | 1 |
| Verhagen, H | 1 |
| Hantson, P | 1 |
| de Saint-Georges, L | 1 |
| Mahieu, P | 1 |
| Léonard, ED | 1 |
| Crutzen-Fayt, MC | 1 |
| Léonard, A | 1 |
| Chételat, A | 1 |
| Albertini, S | 1 |
| Gocke, E | 2 |
| Giri, AK | 1 |
| Sivam, SS | 1 |
| Khan, KA | 1 |
| Kirkland, DJ | 1 |
| Dresp, JH | 1 |
| Marshall, RR | 1 |
| Baumeister, M | 1 |
| Gerloff, C | 1 |
| Kasper, P | 1 |
| Madle, S | 1 |
| Hongslo, JK | 1 |
| Bjørge, C | 1 |
| Schwarze, PE | 1 |
| Brøgger, A | 1 |
| Mann, G | 1 |
| Thelander, L | 1 |
| Holme, JA | 1 |
| Srám, RJ | 2 |
| Kocisová, J | 2 |
| Rössner, P | 2 |
| Binková, B | 2 |
| Topinka, J | 2 |
| Bavorová, H | 2 |
| Shimane, Y | 1 |
3 reviews available for acetaminophen and Abnormalities, Autosome
| Article | Year |
|---|---|
A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential.
Topics: Acetaminophen; Animals; Carcinogenesis; Cell Cycle; Chromosome Aberrations; DNA Damage; Humans; Muta | 2021 |
Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.
Topics: Acetaminophen; Acetanilides; Aminophenols; Aniline Compounds; Animals; Carcinogenicity Tests; Carcin | 2005 |
Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacteria; Biotransformation; Carcinogens; Cell Lin | 1996 |
2 trials available for acetaminophen and Abnormalities, Autosome
| Article | Year |
|---|---|
Effect of short-term dietary administration of eugenol in humans.
Topics: Acetaminophen; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Biotransformat | 1996 |
Normal chromosomal aberration frequencies in peripheral lymphocytes of healthy human volunteers exposed to a maximum daily dose of paracetamol in a double blind trial.
Topics: Acetaminophen; Adult; Cell Cycle; Chromosome Aberrations; Double-Blind Method; Female; Humans; Liver | 1992 |
15 other studies available for acetaminophen and Abnormalities, Autosome
| Article | Year |
|---|---|
Inhibitory activity of black mulberry (Morus nigra) extract against testicular, liver and kidney toxicity induced by paracetamol in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chromosome Aberrations; Comet Assay; | 2020 |
Cytogenetic evaluation of paracetamol effects in human lymphocytes culture.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cell Division; Cells, Cultured; Chromatids; Chromosome Aber | 2007 |
Additional effect of acetaminophen on the mutagenicity and clastogenicity of N-methyl-N'-nitro-N-nitrosoguanidine in cultured Chinese hamster CHO-Kl cells.
Topics: Acetaminophen; Animals; Carcinogens; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Drug | 1983 |
[Cytogenetic effects of antipyretic analgesics on human lymphocytes].
Topics: Acetaminophen; Adult; Aspirin; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Mal | 1982 |
[The effects of aspirin and acetaminophen during pregnancy on chromosomal structure in rat fetuses].
Topics: Acetaminophen; Animals; Aspirin; Chromosome Aberrations; Chromosome Disorders; Female; Fetus; Karyot | 1982 |
Cytogenetical action of Paracetamol on meiotic cells of male mice.
Topics: Acetaminophen; Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Male; Meiosis; Mic | 1980 |
Evaluation of the ability of paracetamol to produce chromosome aberrations in man.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chromosome Aberrations; Female; Humans; | 1996 |
Alleged in vivo genotoxicity of paracetamol and green S.
Topics: Acetaminophen; Animals; Chromosome Aberrations; Food Coloring Agents; Lissamine Green Dyes; Mice; Mu | 1992 |
Sister-chromatid exchange and chromosome aberrations induced by paracetamol in vivo in bone-marrow cells of mice.
Topics: Acetaminophen; Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Female; Male; Mice; | 1992 |
Further investigations on the clastogenicity of paracetamol and acetylsalicylic acid in vitro.
Topics: Acetaminophen; Animals; Aspirin; Biotransformation; Cell Line; Cells, Cultured; Chromosome Aberratio | 1991 |
Paracetamol inhibits replicative DNA synthesis and induces sister chromatid exchange and chromosomal aberrations by inhibition of ribonucleotide reductase.
Topics: Acetaminophen; Animals; Cell Division; Chromosome Aberrations; DNA Replication; Drug Resistance; Ele | 1990 |
Mutagenic activity of paracetamol. A study conducted on volunteers.
Topics: Acetaminophen; Adult; Ascorbic Acid; Chromosome Aberrations; Female; Humans; Lipid Peroxidation; Mal | 1990 |
[Mutagenic activity of paracetamol. A study in volunteers].
Topics: Acetaminophen; Adult; Ascorbic Acid; Chromosome Aberrations; DNA; Female; Humans; Lipid Peroxidation | 1989 |
Enhancing effect of acetaminophen on mutagenesis.
Topics: Acetaminophen; Acetanilides; Animals; Bone Marrow; Cell Line; Chromosome Aberrations; Cricetinae; Cr | 1986 |
[Mutagenicity of acetaminophen on Chinese hamster V79 cells].
Topics: Acetaminophen; Animals; Cell Cycle; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Dose- | 1985 |