Page last updated: 2024-10-22

acetaminophen and ADDH

acetaminophen has been researched along with ADDH in 45 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"Bias analysis suggests that the previously reported association between acetaminophen use during pregnancy and an increased risk of ADHD in the offspring may be due to unmeasured confounding."9.05Acetaminophen use during pregnancy and the risk of attention deficit hyperactivity disorder: A causal association or bias? ( Filion, KB; Masarwa, R; Platt, RW, 2020)
"7%) who reported using acetaminophen during pregnancy."8.12Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study. ( Kjerulff, KH; Sznajder, KK; Teti, DM, 2022)
"Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied on maternal self-report."7.96Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. ( Azuine, RE; Hong, X; Hou, W; Ji, Y; Pearson, C; Riley, A; Wang, G; Wang, X; Zhang, Y; Zuckerman, B, 2020)
"Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy."7.83Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study. ( Liew, Z; Olsen, J; Ritz, B; Virk, J, 2016)
"Maternal prenatal acetaminophen use at 18 (n = 4415; 53%) and 32 weeks of pregnancy (n = 3381; 42%) was associated with higher odds of having conduct problems (risk ratio [RR], 1."7.83Association of Acetaminophen Use During Pregnancy With Behavioral Problems in Childhood: Evidence Against Confounding. ( Davey Smith, G; Stergiakouli, E; Thapar, A, 2016)
"Acetaminophen use during pregnancy was assessed prospectively via 3 computer-assisted telephone interviews during pregnancy and 6 months after child birth."7.80Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. ( Lee, PC; Liew, Z; Olsen, J; Rebordosa, C; Ritz, B, 2014)
"These findings strengthen the contention that acetaminophen exposure in pregnancy increases the risk of ADHD-like behaviours."7.80Associations between acetaminophen use during pregnancy and ADHD symptoms measured at ages 7 and 11 years. ( Mitchell, EA; Murphy, R; Thompson, JM; Waldie, KE; Wall, CR, 2014)
"Acetaminophen is a frequently used analgesic for pain and fever."5.41In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis. ( Albanese, CM; Barrett, K; Brown, HK; Fatima, M; Levis, B; Li, J; Pablo, LA; Ricci, C, 2023)
"Paracetamol (acetaminophen) use during pregnancy and early childhood was accepted as safe in the 1970s, but is now a subject of considerable concern."5.22The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence. ( Anderson, LG; Bono-Lunn, D; Cendejas Hernandez, J; Jones Iii, JP; Konsoula, Z; Kuchibhatla, M; Lawton, VG; Palkar, A; Parker, W; Patel, E; Reissner, KJ; Sarafian, JT, 2022)
"We provided n-of-1 trials for osteoarthritis (OA), comparing paracetamol and ibuprofen; and attention deficit hyperactivity disorder (ADHD), comparing dexamphetamine or methylphenidate and placebo."5.11Using n-of-1 trials as a clinical tool to improve prescribing. ( Clavarino, AM; Del Mar, CB; Nikles, CJ, 2005)
"Bias analysis suggests that the previously reported association between acetaminophen use during pregnancy and an increased risk of ADHD in the offspring may be due to unmeasured confounding."5.05Acetaminophen use during pregnancy and the risk of attention deficit hyperactivity disorder: A causal association or bias? ( Filion, KB; Masarwa, R; Platt, RW, 2020)
"Maternal pre-pregnancy obesity and overweight; pre-eclampsia, hypertension, acetaminophen exposure, and smoking during pregnancy; and childhood atopic diseases were strongly associated with ADHD."5.05Environmental risk factors, protective factors, and peripheral biomarkers for ADHD: an umbrella review. ( Brunoni, AR; Carvalho, AF; Dragioti, E; Fornaro, M; Fusar-Poli, P; Grabovac, I; Hong, SH; Jacob, L; Jeong, GH; Kim, JH; Kim, JY; Koyanagi, A; Kronbichler, A; Lee, E; Lee, J; Lee, KH; Lee, S; Oh, H; Radua, J; Rais, TB; Salazar de Pablo, G; Schuch, F; Shin, JI; Smith, L; Solmi, M; Stickley, A; Stubbs, B; Thompson, T; Yang, L, 2020)
"Acetaminophen is a widely used medication for fever and pain management during pregnancy."5.01Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis. ( Gou, X; Mu, D; Qu, Y; Shi, J; Tang, J; Tang, Y; Wang, Y; Xiao, D, 2019)
"The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy."4.98Prenatal paracetamol exposure and child neurodevelopment: A review. ( Bauer, AZ; Bornehag, CG; Herbert, MR; Kriebel, D; Swan, SH, 2018)
"Acetaminophen is the analgesic and antipyretic most commonly used during pregnancy."4.98Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. ( Gorelik, E; Levine, H; Masarwa, R; Matok, I; Perlman, A; Reif, S, 2018)
"A number of studies indicate that acetaminophen taken during pregnancy may have a programming effect on the fetal brain development."4.95Fetal programming of mental health by acetaminophen? Response to the SMFM statement: prenatal acetaminophen use and ADHD. ( Liew, Z; Olsen, J, 2017)
"Paracetamol (acetaminophen) remains the first line for the treatment of pain and fever in pregnancy."4.91Use of paracetamol during pregnancy and child neurological development. ( Dan, B; de Fays, L; De Smet, K; Dogné, JM; Hamdani, J; Sawchik, J; Van Malderen, K; Verlinden, V, 2015)
"Studies comparing self-reported maternal acetaminophen use during pregnancy to development of ADHD or ADHD-like behaviors in offspring between the ages of 3 and 12 years."4.91Association Between Prenatal Acetaminophen Exposure and Future Risk of Attention Deficit/Hyperactivity Disorder in Children. ( Erramouspe, J; Hayes, VA; Hoover, RM, 2015)
"7%) who reported using acetaminophen during pregnancy."4.12Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study. ( Kjerulff, KH; Sznajder, KK; Teti, DM, 2022)
" 2018;187(8):1817-1827) conducted a meta-analysis of the association between in utero acetaminophen exposure and risks of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)."3.96Invited Commentary: The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology. ( Gilman, SE; Hornig, M, 2020)
"Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied on maternal self-report."3.96Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. ( Azuine, RE; Hong, X; Hou, W; Ji, Y; Pearson, C; Riley, A; Wang, G; Wang, X; Zhang, Y; Zuckerman, B, 2020)
"Together with the multitude of other cohort studies showing adverse neurodevelopment associated with prenatal acetaminophen exposure, this work suggests caution should be used in administering acetaminophen during pregnancy."3.96Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity. ( Aw, N; Baccarelli, AA; Baker, BH; Bellenger, JP; Boivin, A; Gillet, V; Laue, HE; Lepage, JF; Lugo-Candelas, C; Posner, J; Rahman, T; Takser, L; Whittingstall, K; Wu, H, 2020)
" Maternal use of acetaminophen was assessed in the first trimester, second trimester, and third trimester of pregnancy and over the period from 3 months before pregnancy to the date of last menstrual cycle."3.91Prenatal Exposure to Acetaminophen and the Risk of Attention-Deficit/Hyperactivity Disorder: A Nationwide Study in Taiwan. ( Bai, YM; Chen, MH; Chen, TJ; Hsu, JW; Huang, KL; Li, CT; Lin, WC; Pan, TL; Su, TP; Tsai, SJ; Wang, PW, 2019)
"Frequent maternal use of acetaminophen in pregnancy has been linked to attention-deficit/hyperactivity disorder (ADHD) in children, but concerns regarding uncontrolled confounding remain."3.91Use of Negative Control Exposure Analysis to Evaluate Confounding: An Example of Acetaminophen Exposure and Attention-Deficit/Hyperactivity Disorder in Nurses' Health Study II. ( Ascherio, A; Kioumourtzoglou, MA; Liew, Z; O'Reilly, ÉJ; Roberts, AL; Weisskopf, MG, 2019)
"Short-term maternal use of acetaminophen during pregnancy was negatively associated with ADHD in offspring."3.85Prenatal Exposure to Acetaminophen and Risk of ADHD. ( Brandlistuen, RE; Davey Smith, G; Gustavson, K; Håberg, SE; Hornig, M; Knudsen, GP; Lipkin, WI; Magnus, P; Nordeng, H; Reichborn-Kjennerud, T; Stoltenberg, C; Surén, P; Susser, E; Ystrom, E, 2017)
"Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy."3.83Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study. ( Liew, Z; Olsen, J; Ritz, B; Virk, J, 2016)
"Maternal prenatal acetaminophen use at 18 (n = 4415; 53%) and 32 weeks of pregnancy (n = 3381; 42%) was associated with higher odds of having conduct problems (risk ratio [RR], 1."3.83Association of Acetaminophen Use During Pregnancy With Behavioral Problems in Childhood: Evidence Against Confounding. ( Davey Smith, G; Stergiakouli, E; Thapar, A, 2016)
"Acetaminophen use during pregnancy was assessed prospectively via 3 computer-assisted telephone interviews during pregnancy and 6 months after child birth."3.80Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. ( Lee, PC; Liew, Z; Olsen, J; Rebordosa, C; Ritz, B, 2014)
"These findings strengthen the contention that acetaminophen exposure in pregnancy increases the risk of ADHD-like behaviours."3.80Associations between acetaminophen use during pregnancy and ADHD symptoms measured at ages 7 and 11 years. ( Mitchell, EA; Murphy, R; Thompson, JM; Waldie, KE; Wall, CR, 2014)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (6.67)29.6817
2010's27 (60.00)24.3611
2020's15 (33.33)2.80

Authors

AuthorsStudies
Bührer, C1
Endesfelder, S1
Scheuer, T1
Schmitz, T1
Patel, E1
Jones Iii, JP1
Bono-Lunn, D1
Kuchibhatla, M1
Palkar, A1
Cendejas Hernandez, J1
Sarafian, JT1
Lawton, VG1
Anderson, LG1
Konsoula, Z1
Reissner, KJ1
Parker, W1
Sznajder, KK1
Teti, DM1
Kjerulff, KH1
Qutob, HMH1
Saad, RA1
Bali, H1
Osailan, A1
Jaber, J1
Alzahrani, E1
Alyami, J1
Elsayed, H1
Alserihi, R1
Shaikhomar, OA1
Divya, KM1
Savitha, DP1
Krishna, GA1
Dhanya, TM1
Mohanan, PV1
Shah, SF1
Jafry, AT1
Hussain, G1
Kazim, AH1
Ali, M1
Rivani, E1
Endraswari, PD1
Widodo, ADW1
Khalil, MR1
Guldberg, R1
Nørgård, BM1
Uldbjerg, N1
Wehberg, S1
Fowobaje, KR1
Mashood, LO1
Ekholuenetale, M1
Ibidoja, OJ1
Romagnoli, A1
D'Agostino, M1
Pavoni, E1
Ardiccioni, C1
Motta, S1
Crippa, P1
Biagetti, G1
Notarstefano, V1
Rexha, J1
Perta, N1
Barocci, S1
Costabile, BK1
Colasurdo, G1
Caucci, S1
Mencarelli, D1
Turchetti, C1
Farina, M1
Pierantoni, L1
La Teana, A1
Al Hadi, R1
Cicconardi, F1
Chinappi, M1
Trucchi, E1
Mancia, F1
Menzo, S1
Morozzo Della Rocca, B1
D'Annessa, I1
Di Marino, D1
Choya, A1
de Rivas, B1
Gutiérrez-Ortiz, JI1
López-Fonseca, R1
Xu, S1
Cheng, B1
Huang, Z1
Liu, T1
Li, Y1
Jiang, L1
Guo, W1
Xiong, J1
Amirazodi, M1
Daryanoosh, F1
Mehrabi, A1
Gaeini, A1
Koushkie Jahromi, M1
Salesi, M1
Zarifkar, AH1
Studeny, P1
Netukova, M1
Nemcokova, M1
Klimesova, YM1
Krizova, D1
Kang, H1
Tao, Y1
Zhang, Q1
Sha, D1
Chen, Y1
Yao, J1
Gao, Y1
Liu, J1
Ji, L1
Shi, P1
Shi, C1
Wu, YL1
Wright, AI1
M El-Metwaly, N1
A Katouah, H1
El-Desouky, MG1
El-Bindary, AA1
El-Bindary, MA1
Kostakis, ID1
Raptis, DA1
Davidson, BR1
Iype, S1
Nasralla, D1
Imber, C1
Sharma, D1
Pissanou, T1
Pollok, JM1
Hughes, AM1
Sanderson, E1
Morris, T1
Ayorech, Z1
Tesli, M1
Ask, H2
Reichborn-Kjennerud, T4
Andreassen, OA1
Magnus, P3
Helgeland, Ø1
Johansson, S1
Njølstad, P1
Davey Smith, G3
Havdahl, A1
Howe, LD1
Davies, NM1
Amrillah, T1
Prasetio, A1
Supandi, AR1
Sidiq, DH1
Putra, FS1
Nugroho, MA1
Salsabilla, Z1
Azmi, R1
Grammatikopoulos, P1
Bouloumis, T1
Steinhauer, S1
Mironov, VS2
Bazhenova, TA2
Manakin, YV2
Yagubskii, EB2
Yakushev, IA1
Gilmutdinov, IF1
Simonov, SV1
Lan, K1
Yang, H1
Zheng, J1
Hu, H1
Zhu, T1
Zou, X1
Hu, B1
Liu, H1
Olokede, O1
Wu, H2
Holtzapple, M1
Gungor, O1
Kose, M1
Ghaemi, R1
Acker, M1
Stosic, A1
Jacobs, R1
Selvaganapathy, PR1
Ludwig, N1
Yerneni, SS1
Azambuja, JH1
Pietrowska, M1
Widłak, P1
Hinck, CS1
Głuszko, A1
Szczepański, MJ1
Kärmer, T1
Kallinger, I1
Schulz, D1
Bauer, RJ1
Spanier, G1
Spoerl, S1
Meier, JK1
Ettl, T1
Razzo, BM1
Reichert, TE1
Hinck, AP1
Whiteside, TL1
Wei, ZL1
Juan, W1
Tong, D1
Juan, LX1
Sa, LY1
Jie, HFM1
Xiao, G1
Xiang, LG1
Jie, HM1
Xu, C1
Yu, DN1
Yao, ZX1
Bigdeli, F1
Gao, XM1
Cheng, X1
Li, JZ1
Zhang, JW1
Wang, W2
Guan, ZJ1
Bu, Y1
Liu, KG1
Morsali, A1
Das, R1
Paul, R1
Parui, A1
Shrotri, A1
Atzori, C1
Lomachenko, KA1
Singh, AK1
Mondal, J1
Peter, SC1
Florimbio, AR1
Coughlin, LN1
Bauermeister, JA1
Young, SD1
Zimmerman, MA1
Walton, MA1
Bonar, EE1
Demir, D1
Balci, AB1
Kahraman, N1
Sunbul, SA1
Gucu, A1
Seker, IB1
Badem, S1
Yuksel, A1
Ozyazicioglu, AF1
Goncu, MT1
Zhang, H1
Zhou, H1
Deng, Z1
Luo, L1
Ong, SP1
Wang, C1
Xin, H1
Whittingham, MS1
Zhou, G1
Maemura, R1
Wakamatsu, M1
Matsumoto, K1
Sakaguchi, H1
Yoshida, N1
Hama, A1
Yoshida, T1
Miwata, S1
Kitazawa, H1
Narita, K1
Kataoka, S1
Ichikawa, D1
Hamada, M1
Taniguchi, R1
Suzuki, K1
Kawashima, N1
Nishikawa, E1
Narita, A1
Okuno, Y1
Nishio, N1
Kato, K1
Kojima, S1
Morita, K1
Muramatsu, H1
Takahashi, Y1
Yirgu, A1
Mekonnen, Y1
Eyado, A1
Staropoli, A1
Vinale, F1
Zac, J1
Zac, S1
Pérez-Padilla, R1
Remigio-Luna, A1
Guzmán-Boulloud, N1
Gochicoa-Rangel, L1
Guzmán-Valderrábano, C1
Thirión-Romero, I1
Statsenko, ME1
Turkina, SV1
Barantsevich, ER1
Karakulova, YV1
Baranova, NS1
Morzhukhina, MV1
Wang, Q1
Gu, Y1
Chen, C1
Qiao, L1
Pan, F1
Song, C1
Canetto, SS1
Entilli, L1
Cerbo, I1
Cipolletta, S1
Wu, Y2
Zhu, P1
Jiang, Y1
Zhang, X1
Wang, Z1
Xie, B1
Song, T1
Zhang, F1
Luo, A1
Li, S1
Xiong, X1
Han, J1
Peng, X1
Li, M1
Huang, L1
Chen, Q1
Fang, W1
Hou, Y1
Zhu, Y1
Ye, J1
Liu, L1
Islam, MR1
Sanderson, P1
Johansen, MP1
Payne, TE1
Naidu, R1
Cao, J1
Yang, J1
Niu, X1
Liu, X1
Zhai, Y1
Qiang, C1
Niu, Y1
Li, Z1
Dong, N1
Wen, B1
Ouyang, Z1
Zhang, Y2
Li, J3
Zhao, M1
Zhao, J1
Morici, P1
Rizzato, C1
Ghelardi, E1
Rossolini, GM1
Lupetti, A1
Gözüküçük, R1
Cakiroglu, B1
He, X1
Li, R1
Zhao, D1
Zhang, L1
Ji, X1
Fan, X1
Chen, J1
Wang, Y2
Luo, Y1
Zheng, D1
Xie, L1
Sun, S1
Cai, Z1
Liu, Q1
Ma, K1
Sun, X1
Drinkwater, JJ1
Davis, TME1
Turner, AW1
Davis, WA1
Suzuki, Y1
Mizuta, Y1
Mikagi, A1
Misawa-Suzuki, T1
Tsuchido, Y1
Sugaya, T1
Hashimoto, T1
Ema, K1
Hayashita, T1
Ricci, C1
Albanese, CM1
Pablo, LA1
Fatima, M1
Barrett, K1
Levis, B1
Brown, HK1
Chen, MH1
Pan, TL1
Wang, PW1
Hsu, JW1
Huang, KL1
Su, TP1
Li, CT1
Lin, WC1
Tsai, SJ1
Chen, TJ1
Bai, YM1
Masarwa, R4
Perlman, A3
Levine, H3
Matok, I3
Gilman, SE1
Hornig, M3
Ji, Y1
Azuine, RE1
Hou, W1
Hong, X1
Wang, G1
Riley, A1
Pearson, C1
Zuckerman, B1
Wang, X1
Platt, RW1
Filion, KB1
Talge, NM1
Wood, ME1
Damkier, P2
Baker, BH1
Lugo-Candelas, C1
Laue, HE1
Boivin, A1
Gillet, V1
Aw, N1
Rahman, T1
Lepage, JF1
Whittingstall, K1
Bellenger, JP1
Posner, J1
Takser, L1
Baccarelli, AA1
Kim, JH1
Kim, JY1
Lee, J1
Jeong, GH1
Lee, E1
Lee, S1
Lee, KH1
Kronbichler, A1
Stubbs, B1
Solmi, M1
Koyanagi, A1
Hong, SH1
Dragioti, E1
Jacob, L1
Brunoni, AR1
Carvalho, AF1
Radua, J1
Thompson, T1
Smith, L1
Oh, H1
Yang, L1
Grabovac, I1
Schuch, F1
Fornaro, M1
Stickley, A1
Rais, TB1
Salazar de Pablo, G1
Shin, JI1
Fusar-Poli, P1
Alemany, S1
Avella-García, C1
Liew, Z7
García-Esteban, R1
Inoue, K1
Cadman, T1
López-Vicente, M1
González, L1
Riaño Galán, I1
Andiarena, A1
Casas, M1
Margetaki, K1
Strandberg-Larsen, K1
Lawlor, DA1
El Marroun, H1
Tiemeier, H1
Iñiguez, C1
Tardón, A1
Santa-Marina, L1
Júlvez, J1
Porta, D1
Chatzi, L1
Sunyer, J1
Gervin, K1
Nordeng, H2
Ystrom, E3
Lyle, R1
Olsen, J5
Gustavson, K2
Brandlistuen, RE1
Knudsen, GP2
Susser, E1
Stoltenberg, C2
Surén, P2
Håberg, SE2
Lipkin, WI2
Wolraich, ML1
Bauer, AZ1
Kriebel, D1
Herbert, MR1
Bornehag, CG1
Swan, SH1
Gorelik, E1
Reif, S1
Gou, X1
Tang, Y1
Qu, Y1
Tang, J1
Shi, J1
Xiao, D1
Mu, D1
Kioumourtzoglou, MA1
Roberts, AL1
O'Reilly, ÉJ1
Ascherio, A1
Weisskopf, MG1
Eilertsen, E1
Bresnahan, M1
Aase, H1
Mjaaland, S1
Susser, ES1
Cooper, M1
Langley, K1
Thapar, A2
Ritz, B4
Rebordosa, C1
Lee, PC1
Blaser, JA1
Allan, GM1
Amitai, Y1
Thompson, JM1
Waldie, KE1
Wall, CR1
Murphy, R1
Mitchell, EA1
de Fays, L1
Van Malderen, K1
De Smet, K1
Sawchik, J1
Verlinden, V1
Hamdani, J1
Dogné, JM1
Dan, B1
Hergüner, S1
Özayhan, HY1
Hoover, RM1
Hayes, VA1
Erramouspe, J1
Virk, J1
Andrade, C1
Reuter, I1
Knaup, S1
Romanos, M1
Lesch, KP1
Drepper, C1
Lillesaar, C1
Saad, A1
Hegde, S1
Kechichian, T1
Gamble, P1
Rahman, M1
Stutz, SJ1
Anastasio, NC1
Alshehri, W1
Lei, J1
Mori, S1
Kajs, B1
Cunningham, KA1
Saade, G1
Burd, I1
Costantine, M1
Stergiakouli, E1
Bach, CC1
Asarnow, RF1
Jafri, SH1
Cook, JW1
Reed, RR1
Beebe, DK1
Nikles, CJ1
Clavarino, AM1
Del Mar, CB1
Rodnick, JE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Long Term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm Infants by Acetaminophen) Study (TREOCAPA-LT)[NCT06064825]500 participants (Anticipated)Observational2023-11-30Not yet recruiting
Early Clinical Evaluation and Intervention of Developmental Behavioral Diseases Based on Multicenter Cohort Study[NCT06025890]2,100 participants (Anticipated)Interventional2022-12-07Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for acetaminophen and ADDH

ArticleYear
Paracetamol (Acetaminophen) and the Developing Brain.
    International journal of molecular sciences, 2021, Oct-15, Volume: 22, Issue:20

    Topics: Acetaminophen; Adult; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Auti

2021
The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence.
    Minerva pediatrics, 2022, Volume: 74, Issue:6

    Topics: Acetaminophen; Animals; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Chi

2022
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis.
    Paediatric and perinatal epidemiology, 2023, Volume: 37, Issue:5

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Child; Europe; Humans; Pain; Prospecti

2023
Acetaminophen use during pregnancy and the risk of attention deficit hyperactivity disorder: A causal association or bias?
    Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Bias; Child;

2020
Environmental risk factors, protective factors, and peripheral biomarkers for ADHD: an umbrella review.
    The lancet. Psychiatry, 2020, Volume: 7, Issue:11

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Biomarkers; Female; Humans; Pre-Eclamp

2020
Fetal programming of mental health by acetaminophen? Response to the SMFM statement: prenatal acetaminophen use and ADHD.
    Expert opinion on drug safety, 2017, Volume: 16, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Confounding

2017
Prenatal paracetamol exposure and child neurodevelopment: A review.
    Hormones and behavior, 2018, Volume: 101

    Topics: Acetaminophen; Attention; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; C

2018
Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies.
    American journal of epidemiology, 2018, 08-01, Volume: 187, Issue:8

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Female; Huma

2018
Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis.
    The Australian and New Zealand journal of psychiatry, 2019, Volume: 53, Issue:3

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Female; Humans; Pregnancy; Prenatal Ex

2019
Use of paracetamol during pregnancy and child neurological development.
    Developmental medicine and child neurology, 2015, Volume: 57, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Attention Deficit Disorder with Hyperactivity; Chi

2015
Association Between Prenatal Acetaminophen Exposure and Future Risk of Attention Deficit/Hyperactivity Disorder in Children.
    The Annals of pharmacotherapy, 2015, Volume: 49, Issue:12

    Topics: Acetaminophen; Analgesics; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, P

2015

Trials

2 trials available for acetaminophen and ADDH

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
Using n-of-1 trials as a clinical tool to improve prescribing.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2005, Volume: 55, Issue:512

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hy

2005

Other Studies

32 other studies available for acetaminophen and ADDH

ArticleYear
Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Child, Preschool; Female; Humans; Infa

2022
Prenatal Exposure to Acetaminophen and the Risk of Attention-Deficit/Hyperactivity Disorder: A Nationwide Study in Taiwan.
    The Journal of clinical psychiatry, 2019, 09-10, Volume: 80, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Case-

2019
Masarwa et al. Respond to "The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology".
    American journal of epidemiology, 2020, 01-31, Volume: 189, Issue:1

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Cohort Studies; Fem

2020
Invited Commentary: The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology.
    American journal of epidemiology, 2020, 01-31, Volume: 189, Issue:1

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Autistic Dis

2020
Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.
    JAMA psychiatry, 2020, 02-01, Volume: 77, Issue:2

    Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bioma

2020
Prenatal acetaminophen exposure and neurodevelopment: State of the evidence.
    Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3

    Topics: Acetaminophen; Adaptation, Physiological; Analgesics, Non-Narcotic; Attention Deficit Disorder with

2020
Associations between prenatal acetaminophen exposure and child neurodevelopment: Truth, bias, or a bit of both?
    Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Bias; Centra

2020
Simple twist of fate: In utero exposure to acetaminophen and risk of childhood Attention Deficit Hyperactivity Disorder.
    Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Bias; Child; Female; Humans; Pregnancy

2020
Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity.
    JAMA pediatrics, 2020, 11-01, Volume: 174, Issue:11

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Child; Connectome; Female; Follow-Up S

2020
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts.
    European journal of epidemiology, 2021, Volume: 36, Issue:10

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attention; Attention Deficit Disorder with Hyperacti

2021
Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.
    Clinical epigenetics, 2017, Volume: 9

    Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; DNA Methy

2017
Prenatal Exposure to Acetaminophen and Risk of ADHD.
    Pediatrics, 2017, Volume: 140, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity;

2017
An Association Between Prenatal Acetaminophen Use and ADHD: The Benefits of Large Data Sets.
    Pediatrics, 2017, Volume: 140, Issue:5

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Humans; Prenatal Exposure Delayed Effe

2017
FOUR AUTHORS REPLY.
    American journal of epidemiology, 2018, 12-01, Volume: 187, Issue:12

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Cohort Studi

2018
RE: "PRENATAL EXPOSURE TO ACETAMINOPHEN AND RISK FOR ATTENTION DEFICIT HYPERACTIVITY DISORDER AND AUTISTIC SPECTRUM DISORDER: A SYSTEMATIC REVIEW, META-ANALYSIS, AND META-REGRESSION ANALYSIS OF COHORT STUDIES".
    American journal of epidemiology, 2018, 12-01, Volume: 187, Issue:12

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Cohort Studi

2018
Use of Negative Control Exposure Analysis to Evaluate Confounding: An Example of Acetaminophen Exposure and Attention-Deficit/Hyperactivity Disorder in Nurses' Health Study II.
    American journal of epidemiology, 2019, 04-01, Volume: 188, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Child

2019
Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder.
    Scientific reports, 2019, 07-02, Volume: 9, Issue:1

    Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Child; Cohort Studies; Female;

2019
Antenatal acetaminophen use and attention-deficit/hyperactivity disorder: an interesting observed association but too early to infer causality.
    JAMA pediatrics, 2014, Volume: 168, Issue:4

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Female; Humans; Hyperkinesis; Male; Me

2014
Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders.
    JAMA pediatrics, 2014, Volume: 168, Issue:4

    Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Denmar

2014
Acetaminophen in pregnancy and future risk of ADHD in offspring.
    Canadian family physician Medecin de famille canadien, 2014, Volume: 60, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Female; Huma

2014
Characteristics of acetaminophen users compared with nonusers during pregnancy, behavioral problems, and hyperkinetic disorders.
    JAMA pediatrics, 2014, Volume: 168, Issue:9

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Female; Humans; Hyperkinesis; Male; Me

2014
Characteristics of acetaminophen users compared with nonusers during pregnancy, behavioral problems, and hyperkinetic disorders--reply.
    JAMA pediatrics, 2014, Volume: 168, Issue:9

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Female; Humans; Hyperkinesis; Male; Me

2014
Associations between acetaminophen use during pregnancy and ADHD symptoms measured at ages 7 and 11 years.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Child; Femal

2014
Visual Hallucinations with Methylphenidate and Acetaminophen in Combination.
    Journal of child and adolescent psychopharmacology, 2015, Volume: 25, Issue:7

    Topics: Acetaminophen; Antipyretics; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit

2015
Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study.
    Autism research : official journal of the International Society for Autism Research, 2016, Volume: 9, Issue:9

    Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child

2016
Use of acetaminophen (paracetamol) during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring.
    The Journal of clinical psychiatry, 2016, Volume: 77, Issue:3

    Topics: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Female; Humans; Male; Pregnancy; Prena

2016
Developmental exposure to acetaminophen does not induce hyperactivity in zebrafish larvae.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:8

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Attention Defic

2016
Is There a Causal Relation between Maternal Acetaminophen Administration and ADHD?
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Attention Deficit Disorder with Hyperactivity; Bra

2016
Association of Acetaminophen Use During Pregnancy With Behavioral Problems in Childhood: Evidence Against Confounding.
    JAMA pediatrics, 2016, Oct-01, Volume: 170, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hyperactivity; Child; Child

2016
Paracetamol use during pregnancy and attention and executive function in offspring at age 5 years.
    International journal of epidemiology, 2016, 12-01, Volume: 45, Issue:6

    Topics: Acetaminophen; Adult; Attention; Attention Deficit Disorder with Hyperactivity; Child Development; C

2016
Acute onset of bilateral myoclonus in a 16-year-old female.
    Journal of the Mississippi State Medical Association, 2004, Volume: 45, Issue:6

    Topics: Acetaminophen; Acute Disease; Adolescent; Aspirin; Attention Deficit Disorder with Hyperactivity; Ca

2004
Australia: the N of 1 trial, an underappreciated research method.
    Family medicine, 2006, Volume: 38, Issue:1

    Topics: Acetaminophen; Aged; Attention Deficit Disorder with Hyperactivity; Australia; Child; Child, Prescho

2006