acetaldehyde has been researched along with Neoplasms in 55 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaldehyde formation was determined by GC-FID analysis in the head space of incubation mixtures." | 5.31 | Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects. ( Castro, GD; Castro, JA; Costantini, MH; Delgado de Layño, AM, 2001) |
| "Acetaldehyde is a known carcinogen." | 2.82 | Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. ( Crystal, RG; Montel, RA; Munoz-Zuluaga, C; Stiles, KM, 2022) |
| " The peak concentration and area under the curve (AUC) were determined for the parent compound and the metabolites 4-hydroxyifosfamide and chloracetaldehyde in eight patients who received two cycles of ICE chemotherapy (ifosfamide 5 g/m(2) day 1, carboplatin 300 mg/m(2) day 1, etoposide 100 mg/m(2) days 1-3)." | 2.73 | Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients. ( Brüggemann, SK; Peters, SO; Pfäffle, S; Wagner, T, 2007) |
| "Approximately 4% of cancers worldwide are caused by alcohol consumption." | 2.72 | Alcohol and Cancer: Epidemiology and Biological Mechanisms. ( Ferrari, P; Murphy, N; Rumgay, H; Soerjomataram, I, 2021) |
| "Ifosfamide and mesna were infused over 24 and 36 h, respectively, at equal daily doses; carboplatin was given after ifosfamide to a target plasma area under the curve of 4 mg x min x ml(-1)." | 2.69 | Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione. ( Bolanowska-Higdon, W; Creaven, PJ; Meropol, NJ; Murphy, M; Pendyala, L; Perez, R; Schwartz, G; Zdanowicz, J, 2000) |
| " Independent of the route of ifosfamide application on day 1, the terminal half-life on day 3 (when the drug was given by the alternative route) was decreased in 6 out of the 12 patients, thus indicating self-induction of hepatic metabolism." | 2.67 | Metabolism and pharmacokinetics of oral and intravenous ifosfamide. ( Cerny, T; Küpfer, A; Kurowski, V; Wagner, T, 1991) |
| " After oral application, ifosfamide absorption proceeded rapidly, the oral bioavailability was 0." | 2.67 | Metabolism and pharmacokinetics of oral and intravenous ifosfamide. ( Cerny, T; Küpfer, A; Kurowski, V; Wagner, T, 1991) |
| "Alcohol use is a major contributor to cancer and is linked to the most prevalent types of cancer." | 2.61 | Does Alcohol Use Affect Cancer Risk? ( Ferreira-Borges, C; Rehm, J; Shield, KD; Soerjomataram, I, 2019) |
| "Changes in cancer genes and in signaling pathways (MAPK, RAS, Rb, TGFβ, p53, PTEN, ECM, osteopontin, Wnt) may also contribute to ethanol-mediated mechanisms in carcinogenesis." | 2.52 | Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1. ( Mueller, S; Seitz, HK, 2015) |
| "Since CPA and IFO are widely used anticancer drugs, their efficacy is limited not only by their toxicity but also due to occurring resistance." | 2.49 | [Classical oxazaphosphorines--metabolism and therapeutic properties--new implications]. ( Górska, A; Hładoń, B; Misiura, K; Sikorska, M; Sloderbach, A, 2013) |
| " The risk assessment was conducted using the European Food Safety Authority's margin of exposure (MOE) approach with benchmark doses obtained from dose-response modelling of animal experiments." | 2.45 | Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. ( Kanteres, F; Lachenmeier, DW; Rehm, J, 2009) |
| "Life-time cancer risk was calculated using the T25 dose descriptor." | 2.45 | Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. ( Kanteres, F; Lachenmeier, DW; Rehm, J, 2009) |
| "The life-time cancer risks for acetaldehyde from alcoholic beverages greatly exceed the usual limits for cancer risks from the environment set between 1 : 10,000 and 1 : 1,000,000." | 2.45 | Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. ( Kanteres, F; Lachenmeier, DW; Rehm, J, 2009) |
| "This suggests that cancer cells have a greater capability for ethanol oxidation but less ability to remove acetaldehyde than normal tissues." | 2.44 | Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases. ( Jelski, W; Szmitkowski, M, 2008) |
| " The alpha-dicarbonyl moiety in related substances is believed to induce various toxic responses, such as Alzheimer's disease, mutagenesis, and carcinogenesis." | 2.43 | Role of diacetyl metabolite in alcohol toxicity and addiction via electron transfer and oxidative stress. ( Cooksy, AL; Kovacic, P, 2005) |
| "Highly active cancer-specific shorter Pfk-M fragments appear to trigger several controlling mechanisms in the primary metabolism of yeast S." | 1.46 | Effect of the cancer specific shorter form of human 6-phosphofructo-1-kinase on the metabolism of the yeast Saccharomyces cerevisiae. ( Andrejc, D; Legiša, M; Možir, A, 2017) |
| " Those results are in agreement with literature data reporting that intracellular CAA toxic concentrations range from 35 to 320 μM, after therapeutic ifosfamide dosing." | 1.43 | Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models. ( Bois, FY; Hamon, J; Leclerc, E, 2016) |
| " A pharmacokinetic (PK) model described the production of CAA by the hepatocytes and its transport to the renal cells." | 1.43 | Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models. ( Bois, FY; Hamon, J; Leclerc, E, 2016) |
| "For this purpose, two pairs of cancerous and non-cancerous human cell lines were selected:1." | 1.36 | Discrimination of cancerous and non-cancerous cell lines by headspace-analysis with PTR-MS. ( Bergner, A; Brunner, C; Hoeschen, C; Höllriegl, V; Huber, RM; Mörtl, S; Oeh, U; Oelmez, H; Szymczak, W, 2010) |
| "Since the Fanconi anemia-breast cancer associated (FANC-BRCA) DNA damage response network plays a crucial role in protecting cells against ICLs, in the present work we tested this hypothesis by exposing cells to AA and monitoring activation of this network." | 1.35 | Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis. ( Brooks, PJ; Lamerdin, JE; Marietta, C; Thompson, LH, 2009) |
| "The National Institute on Alcohol Abuse and Alcoholism, Office of Dietary Supplements, Office of Rare Diseases, National Cancer Institute, National Institute on Drug Abuse, and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, sponsored an international symposium on Mechanisms of Alcohol-Associated Cancers in Bethesda, Maryland, USA, October 2004." | 1.33 | Mechanisms of alcohol-associated cancers: introduction and summary of the symposium. ( Khalsa, J; Purohit, V; Serrano, J, 2005) |
| "Acetaldehyde was administered to 50 male and 50 female Sprague-Dawley rats beginning at six weeks of age at concentrations of 2,500, 1,500, 500, 250, 50, or 0 mg/L." | 1.31 | Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. ( Belpoggi, F; Lambertin, L; Lauriola, M; Maltoni, C; Padovani, M; Soffritti, M, 2002) |
| "Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age." | 1.31 | Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. ( Belpoggi, F; Lambertin, L; Lauriola, M; Maltoni, C; Padovani, M; Soffritti, M, 2002) |
| "Acetaldehyde formation was determined by GC-FID analysis in the head space of incubation mixtures." | 1.31 | Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects. ( Castro, GD; Castro, JA; Costantini, MH; Delgado de Layño, AM, 2001) |
| "Using EPA cancer risk estimates, reduction in 1,3-butadiene exposure accounts for the greatest health benefit while reduction of benzene exposure accounts for the greatest health benefits based on alternative risk estimates." | 1.30 | An analysis of the health benefits associated with the use of MTBE reformulated gasoline and oxygenated fuels in reducing atmospheric concentrations of selected volatile organic compounds. ( Spitzer, HL, 1997) |
| " The kinetics of the excretion were compared following short-term and continuous ifosfamide infusion at a dosage of 3 g/m2." | 1.30 | Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion. ( Blaschke, G; Boos, J; Hohenlöchter, B; Jürgens, H; Rossi, R; Silies, H, 1998) |
| "Cortisone treatment of patients suffering from systemic lupus erythematosus and rheumatoid arthritis impressively normalized elevated XOD concentrations in rheumatic sera to those of healthy controls." | 1.29 | Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases. ( Miesel, R; Zuber, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.27) | 18.7374 |
| 1990's | 6 (10.91) | 18.2507 |
| 2000's | 19 (34.55) | 29.6817 |
| 2010's | 18 (32.73) | 24.3611 |
| 2020's | 8 (14.55) | 2.80 |
| Authors | Studies |
|---|---|
| Rumgay, H | 1 |
| Murphy, N | 1 |
| Ferrari, P | 1 |
| Soerjomataram, I | 2 |
| Montel, RA | 1 |
| Munoz-Zuluaga, C | 1 |
| Stiles, KM | 1 |
| Crystal, RG | 1 |
| Thapa, MJ | 1 |
| Fabros, RM | 1 |
| Alasmar, S | 1 |
| Chan, K | 1 |
| Kosmider, L | 1 |
| Cox, S | 1 |
| Zaciera, M | 1 |
| Kurek, J | 1 |
| Goniewicz, ML | 1 |
| McRobbie, H | 1 |
| Kimber, C | 1 |
| Dawkins, L | 1 |
| Salaspuro, M | 2 |
| Lachenmeier, DW | 3 |
| Testino, G | 1 |
| Caputo, F | 1 |
| Patussi, V | 1 |
| Scafato, E | 1 |
| Rogers, CM | 1 |
| Simmons Iii, RH | 1 |
| Fluhler Thornburg, GE | 1 |
| Buehler, NJ | 1 |
| Bochman, ML | 1 |
| Hartwig, A | 1 |
| Eisenbrand, G | 1 |
| Andrejc, D | 1 |
| Možir, A | 1 |
| Legiša, M | 1 |
| Wu, AH | 1 |
| Rehm, J | 3 |
| Ferreira-Borges, C | 1 |
| Shield, KD | 1 |
| Sobh, A | 1 |
| Loguinov, A | 1 |
| Stornetta, A | 1 |
| Balbo, S | 2 |
| Tagmount, A | 1 |
| Zhang, L | 1 |
| Vulpe, CD | 1 |
| Brooks, PJ | 4 |
| Zakhari, S | 1 |
| Sloderbach, A | 1 |
| Górska, A | 1 |
| Sikorska, M | 1 |
| Misiura, K | 1 |
| Hładoń, B | 1 |
| Eriksson, CJ | 1 |
| Seitz, HK | 3 |
| Mueller, S | 1 |
| Heit, C | 1 |
| Dong, H | 1 |
| Chen, Y | 1 |
| Shah, YM | 1 |
| Thompson, DC | 1 |
| Vasiliou, V | 1 |
| Leclerc, E | 1 |
| Hamon, J | 1 |
| Bois, FY | 1 |
| Pflaum, T | 1 |
| Hausler, T | 1 |
| Baumung, C | 1 |
| Ackermann, S | 1 |
| Kuballa, T | 1 |
| Orywal, K | 1 |
| Jelski, W | 2 |
| Szmitkowski, M | 2 |
| Kanteres, F | 1 |
| Marietta, C | 1 |
| Thompson, LH | 1 |
| Lamerdin, JE | 1 |
| Brunner, C | 1 |
| Szymczak, W | 1 |
| Höllriegl, V | 1 |
| Mörtl, S | 1 |
| Oelmez, H | 1 |
| Bergner, A | 1 |
| Huber, RM | 1 |
| Hoeschen, C | 1 |
| Oeh, U | 1 |
| Yokoyama, A | 1 |
| Omori, T | 1 |
| Yokoyama, T | 1 |
| Song, BJ | 1 |
| Abdelmegeed, MA | 1 |
| Yoo, SH | 1 |
| Kim, BJ | 1 |
| Jo, SA | 1 |
| Jo, I | 1 |
| Moon, KH | 1 |
| Latino-Martel, P | 1 |
| Arwidson, P | 1 |
| Ancellin, R | 1 |
| Druesne-Pecollo, N | 1 |
| Hercberg, S | 1 |
| Le Quellec-Nathan, M | 1 |
| Le-Luong, T | 1 |
| Maraninchi, D | 1 |
| Paget, V | 1 |
| Lechevrel, M | 1 |
| André, V | 1 |
| Goff, JL | 1 |
| Pottier, D | 1 |
| Billet, S | 1 |
| Garçon, G | 1 |
| Shirali, P | 1 |
| Sichel, F | 1 |
| Castro, GD | 2 |
| Delgado de Layño, AM | 2 |
| Costantini, MH | 2 |
| Castro, JA | 2 |
| Soffritti, M | 1 |
| Belpoggi, F | 1 |
| Lambertin, L | 1 |
| Lauriola, M | 1 |
| Padovani, M | 1 |
| Maltoni, C | 1 |
| Pöschl, G | 1 |
| Stickel, F | 1 |
| Wang, XD | 1 |
| Savage, P | 1 |
| Cowburn, P | 1 |
| Clemens, D | 1 |
| Hurley, T | 1 |
| Laguda, B | 1 |
| Martin-Duque, P | 1 |
| Vassaux, G | 1 |
| Lemoine, NR | 1 |
| Báez, AP | 1 |
| Padilla, HG | 1 |
| García, RM | 1 |
| Belmont, RD | 1 |
| Torres, Mdel C | 1 |
| Kovacic, P | 1 |
| Cooksy, AL | 1 |
| Purohit, V | 1 |
| Khalsa, J | 1 |
| Serrano, J | 1 |
| Theruvathu, JA | 1 |
| Savolainen, M | 1 |
| Haber, P | 1 |
| Ishii, H | 1 |
| Teschke, R | 2 |
| Moshage, H | 1 |
| Lieber, CS | 1 |
| Burton, A | 1 |
| O'Hanlon, LH | 1 |
| Brüggemann, SK | 1 |
| Pfäffle, S | 1 |
| Peters, SO | 1 |
| Wagner, T | 2 |
| Miesel, R | 1 |
| Zuber, M | 1 |
| Spitzer, HL | 1 |
| Silies, H | 1 |
| Blaschke, G | 1 |
| Hohenlöchter, B | 1 |
| Rossi, R | 1 |
| Jürgens, H | 1 |
| Boos, J | 1 |
| Pendyala, L | 1 |
| Creaven, PJ | 1 |
| Schwartz, G | 1 |
| Meropol, NJ | 1 |
| Bolanowska-Higdon, W | 1 |
| Zdanowicz, J | 1 |
| Murphy, M | 1 |
| Perez, R | 1 |
| Hecht, SS | 1 |
| McIntee, EJ | 1 |
| Wang, M | 1 |
| Lemaire, L | 1 |
| Malet-Martino, MC | 1 |
| de Forni, M | 1 |
| Martino, R | 1 |
| Lasserre, B | 1 |
| Kurowski, V | 1 |
| Cerny, T | 1 |
| Küpfer, A | 1 |
| Keller, DA | 1 |
| Heck, HD | 1 |
| Terrell, JH | 1 |
| Schmeltz, I | 1 |
19 reviews available for acetaldehyde and Neoplasms
| Article | Year |
|---|---|
Alcohol and Cancer: Epidemiology and Biological Mechanisms.
Topics: Acetaldehyde; Alcohol Drinking; Alcohol-Induced Disorders; Carcinogenesis; DNA Damage; DNA Methylati | 2021 |
Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Ethanol; Genetic Therap | 2022 |
Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes.
Topics: Acetaldehyde; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Cross-Linking Reagents; DNA | 2020 |
Does Alcohol Use Affect Cancer Risk?
Topics: Acetaldehyde; Alcohol Drinking; Cost of Illness; Disabled Persons; Humans; Neoplasms; Prevalence; Qu | 2019 |
Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; DNA R | 2014 |
[Classical oxazaphosphorines--metabolism and therapeutic properties--new implications].
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Antineoplastic Agents; Biotransformation; Cyclophosph | 2013 |
Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Allel | 2015 |
Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1.
Topics: Acetaldehyde; Aldehyde Dehydrogenase 1 Family; Animals; Cytochrome P-450 CYP2E1; Ethanol; Humans; Is | 2015 |
Implications of acetaldehyde-derived DNA adducts for understanding alcohol-related carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; DNA A | 2015 |
Carcinogenic compounds in alcoholic beverages: an update.
Topics: Acetaldehyde; Alcoholic Beverages; Carcinogens; Ethanol; Humans; Lead; Neoplasms; Risk Assessment | 2016 |
[Alcohol dehydrogenase and aldehyde dehydrogenase in malignant diseases--part I].
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Causality; Comorbidity; Hum | 2008 |
Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism.
Topics: Acetaldehyde; Alcoholic Beverages; Animals; Carcinogens; Ethanol; Guatemala; Humans; Neoplasms; Risk | 2009 |
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Al | 2010 |
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Asian People; | 2011 |
Alcohol and cancer: genetic and nutritional aspects.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholism; Carcinogens; Cytochrome P-450 CYP2E1; DNA Methylati | 2004 |
Role of diacetyl metabolite in alcohol toxicity and addiction via electron transfer and oxidative stress.
Topics: Acetaldehyde; Alcoholism; Diacetyl; Ethanol; Humans; Mutagenesis; Neoplasms; Oxidation-Reduction; Ox | 2005 |
DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; Animals; DNA Adducts; DNA Repair; Humans; Mutagens; Neoplasms; Polym | 2005 |
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Ethanol; Humans; Isoenzymes; N | 2008 |
Acetaldehyde.
Topics: Acetaldehyde; Animals; Carcinogenicity Tests; Carcinogens; Humans; Mutagenicity Tests; Mutagens; Neo | 1999 |
4 trials available for acetaldehyde and Neoplasms
| Article | Year |
|---|---|
Daily exposure to formaldehyde and acetaldehyde and potential health risk associated with use of high and low nicotine e-liquid concentrations.
Topics: Acetaldehyde; Aerosols; Carcinogens; Electronic Nicotine Delivery Systems; Formaldehyde; Humans; Neo | 2020 |
Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients.
Topics: Acetaldehyde; Adolescent; Adult; Aged; Antiemetics; Antineoplastic Agents, Alkylating; Dexamethasone | 2007 |
Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Cysteine; Dose-Response Relationship, Drug; Glutath | 2000 |
Metabolism and pharmacokinetics of oral and intravenous ifosfamide.
Topics: Acetaldehyde; Administration, Oral; Adult; Aged; Female; Humans; Ifosfamide; Infusions, Intravenous; | 1991 |
32 other studies available for acetaldehyde and Neoplasms
| Article | Year |
|---|---|
Analyses of mutational patterns induced by formaldehyde and acetaldehyde reveal similarity to a common mutational signature.
Topics: Acetaldehyde; DNA Mutational Analysis; Formaldehyde; Humans; Mutagens; Mutation; Neoplasms; Yeasts | 2022 |
Unique human cancer model for acetaldehyde based on Mendelian randomization.
Topics: Acetaldehyde; Carcinogens; DNA Damage; Humans; Mendelian Randomization Analysis; Neoplasms; Risk Ass | 2020 |
Alcohol and cancer: no threshold exists.
Topics: Acetaldehyde; Alcohol Abstinence; Alcohol Drinking; Alcoholic Beverages; Breast Neoplasms; Confidenc | 2020 |
Response to Salaspuro and Lachenmeier, 2020, letter to the editor in Archives of Toxicology.
Topics: Acetaldehyde; Humans; Mendelian Randomization Analysis; Neoplasms | 2020 |
Effect of the cancer specific shorter form of human 6-phosphofructo-1-kinase on the metabolism of the yeast Saccharomyces cerevisiae.
Topics: Acetaldehyde; Ethanol; Fructose; Gas Chromatography-Mass Spectrometry; Glucose; Glycolysis; Humans; | 2017 |
The influence of pharmacogenomics on the protective effect of light-to-moderate alcohol use.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Humans; Neoplasms; Pharmacogenetics | 2018 |
Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde.
Topics: Acetaldehyde; Cell Survival; Cell Transformation, Neoplastic; CRISPR-Cas Systems; DNA Adducts; Dose- | 2019 |
Transgenic mouse models for alcohol metabolism, toxicity, and cancer.
Topics: Acetaldehyde; Animals; Ethanol; Glutathione; Humans; Mice; Mice, Transgenic; Models, Animal; Neoplas | 2015 |
Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Bayes Theorem; Cells, Cultured; Hepatocytes; Ifosfa | 2016 |
Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; BRCA1 Protein; Cell Line; Cross-Linking Reagents; DNA Damage; Ethano | 2009 |
Discrimination of cancerous and non-cancerous cell lines by headspace-analysis with PTR-MS.
Topics: Acetaldehyde; Biomarkers, Tumor; Cell Line; Cell Line, Tumor; Humans; Multivariate Analysis; Neoplas | 2010 |
Alcohol consumption and cancer risk: revisiting guidelines for sensible drinking.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Central Nervous System Depressants; Dose-Response Relati | 2011 |
Acetaldehyde.
Topics: Acetaldehyde; Animals; Carcinogens; Humans; Neoplasms | 2011 |
Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.
Topics: Acetaldehyde; Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Fibroblasts; Humans; Mutagens; Mutation; Ne | 2012 |
Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: its potential contribution to prostate tumor promotion.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Ethanol; Free Radicals; Gas Chromatography-Mass Spectrometr | 2002 |
Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.
Topics: Acetaldehyde; Animals; Carcinogens; Female; Formaldehyde; Male; Neoplasms; Rats; Rats, Sprague-Dawle | 2002 |
Suicide gene therapy: conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase.
Topics: Acetaldehyde; Adenoviridae; Alcohol Dehydrogenase; Cell Proliferation; Ethanol; Gene Transfer Techni | 2004 |
Measurements of carbonyls in a 13-story building.
Topics: Acetaldehyde; Air Pollution, Indoor; Disinfectants; Formaldehyde; Humans; Inhalation Exposure; Mexic | 2004 |
Mechanisms of alcohol-associated cancers: introduction and summary of the symposium.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Carcinogens; Cytochrome P-450 CYP2E1; Ethanol; Humans; N | 2005 |
From alcohol toxicity to treatment.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Related Disorders; Alcoholism; Alleles; Cholestasis, In | 2005 |
Acetaldehyde links alcohol consumption to cancer.
Topics: Acetaldehyde; Alcohol Drinking; Humans; Neoplasms | 2005 |
Studies seek molecular clues on alcohol's role in cancer.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Oxidoreductases; Animals; Cell Cultu | 2005 |
[Alcoholic liver diseases. Biochemical and clinical studies on pathogenesis and early diagnosis].
Topics: Acetaldehyde; Alcohol Oxidoreductases; Biochemical Phenomena; Biochemistry; Catalase; Chlorpromazine | 1980 |
Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases.
Topics: Acetaldehyde; Acquired Immunodeficiency Syndrome; Autoimmune Diseases; Biomarkers; Cohort Studies; C | 1993 |
An analysis of the health benefits associated with the use of MTBE reformulated gasoline and oxygenated fuels in reducing atmospheric concentrations of selected volatile organic compounds.
Topics: Acetaldehyde; Air Pollutants; Air Pollution; Benzene; Benzene Derivatives; Butadienes; Carcinogens; | 1997 |
Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion.
Topics: Acetaldehyde; Acrolein; Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Female; Humans; | 1998 |
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chroma | 2001 |
New DNA adducts of crotonaldehyde and acetaldehyde.
Topics: Acetaldehyde; Aldehydes; Carcinogens; Chemical Phenomena; Chemistry; Deoxyguanosine; DNA Adducts; Hu | 2001 |
Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
Topics: Acetaldehyde; Aged; Animals; Drug Contamination; Female; Fluoroacetates; Fluorouracil; Heart; Humans | 1992 |
Acetaldehyde.
Topics: Acetaldehyde; Acetates; Acetic Acid; Air Pollutants; Animals; Cannabis; Carcinogens; Chemical Phenom | 1985 |
Mechanistic studies on chloral toxicity: relationship to trichloroethylene carcinogenesis.
Topics: Acetaldehyde; Animals; Binding Sites; Cell Nucleus; Chloral Hydrate; Cross-Linking Reagents; DNA; DN | 1988 |
Cigarettes: chemical effects of sodium nitrate content.
Topics: Acetaldehyde; Aldehydes; Carcinogens; Cilia; Neoplasms; Nitrates; Nitric Oxide; Nitrogen Dioxide; Ni | 1968 |