acetaldehyde has been researched along with MPTP Neurotoxicity Syndrome in 4 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In 8-week-old animals, however, acetaldehyde or ethanol given with MPTP decreased striatal DA content to about 10% of controls, whereas the depletion was to 43% of controls when MPTP was given alone." | 1.28 | MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra. ( Corsini, GU; di Porzio, U; Johannessen, JN; Kopin, IJ; Schinelli, S; Zuddas, A, 1989) |
| " In the present study, we measured the accumulation of the MPTP toxic metabolite 1-methyl-4-phenylpyridinium ion (MPP+) in both striatum and whole brain, after MPTP alone or after combined treatments with ethanol or acetaldehyde, in order to determine whether this enhancement of toxicity is caused by changes in the MPTP metabolism." | 1.28 | Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the striatum. ( Barker, JL; Corsini, GU; di Porzio, U; Kopin, IJ; Schinelli, S; Zuddas, A, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vaglini, F | 2 |
| Fascetti, F | 2 |
| Tedeschi, D | 1 |
| Cavalletti, M | 1 |
| Fornai, F | 2 |
| Corsini, GU | 4 |
| Zuddas, A | 3 |
| Saginario, A | 1 |
| Schinelli, S | 2 |
| Johannessen, JN | 1 |
| di Porzio, U | 2 |
| Kopin, IJ | 2 |
| Barker, JL | 1 |
4 other studies available for acetaldehyde and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Ch | 1996 |
Pharmacologic modulation of MPTP toxicity: MK 801 in prevention of dopaminergic cell death in monkeys and mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetaldehyde; Animals; Caudate Nucleus; Cell Death; Co | 1992 |
MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra.
Topics: Acetaldehyde; Aging; Animals; Dopamine; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; | 1989 |
Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; As | 1989 |