Page last updated: 2024-10-16

acetaldehyde and Liver Cirrhosis

acetaldehyde has been researched along with Liver Cirrhosis in 33 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Research Excerpts

ExcerptRelevanceReference
"Hepatic cirrhosis is associated with abnormal red blood cell morphology and function, particularly impaired red blood cell deformability."5.42Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis. ( Anzai, K; Arase, Y; Hirose, S; Kagawa, T; Matsuzaki, S; Mine, T; Shiraishi, K; Tsuruya, K, 2015)
"The risk of liver fibrosis development is potentiated by alcohol abuse."1.91Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol. ( Ganesan, M; Kanika, S; Kharbanda, KK; Koganti, SS; Kumar, V; Makarov, E; New-Aaron, M; Osna, NA; Poluektova, LY; Wang, W, 2023)
"GGT indicates Alcohol Abuse only in background of normal LFT."1.72Serum IgA levels and IgA/IgG ratio in Alcoholic Liver Disease. ( BhatB, NM, 2022)
"24% were in steatosis,32% were in steatohepatitis, while 44% were in cirrhosis."1.72Serum IgA levels and IgA/IgG ratio in Alcoholic Liver Disease. ( BhatB, NM, 2022)
"Alcoholic liver fibrosis(ALF), as a liver disease caused by long-term alcoholism, attracts international attention."1.72Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway. ( Li, ZX; Sheng, XD; Wang, YL; Wen Lv, X, 2022)
"Hepatic cirrhosis is associated with abnormal red blood cell morphology and function, particularly impaired red blood cell deformability."1.42Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis. ( Anzai, K; Arase, Y; Hirose, S; Kagawa, T; Matsuzaki, S; Mine, T; Shiraishi, K; Tsuruya, K, 2015)
"Butein has also been reported to prevent and partly reverse liver fibrosis in vivo, although its mechanism of action is poorly understood."1.37Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. ( Kandefer-Szerszeń, M; Plewka, K; Szuster-Ciesielska, A, 2011)
"Liver fibrosis has been reported to be inhibited in vivo by oleanolic and ursolic acids; however, the activity of other triterpenes like betulin and betulinic acid has not been examined."1.37Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. ( Kandefer-Szerszeń, M; Plewka, K; Szuster-Ciesielska, A, 2011)
"Acetaldehyde-treated cells pretreated with an anti-IL-6 monoclonal antibody did not show any increase in alpha (I) collagen expression."1.35Pentoxifylline downregulates alpha (I) collagen expression by the inhibition of Ikappabalpha degradation in liver stellate cells. ( Bucio, L; Escobar, MC; Farfán, B; Gómez-Quiroz, LE; Gutiérrez-Ruiz, MC; Hernández, E; Kershenobich, D; Souza, V, 2008)
"Liver fibrosis is accompanied by significant increase of collagen content in this organ."1.29Collagen in liver fibrosis induced by ethanol. ( Bańkowski, E, 1994)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199011 (33.33)18.7374
1990's3 (9.09)18.2507
2000's6 (18.18)29.6817
2010's9 (27.27)24.3611
2020's4 (12.12)2.80

Authors

AuthorsStudies
Liu, Z1
Xu, B1
Ding, Y1
Ding, X1
Yang, Z1
BhatB, NM1
Li, ZX1
Sheng, XD1
Wang, YL1
Wen Lv, X1
New-Aaron, M2
Koganti, SS1
Ganesan, M2
Kanika, S1
Kumar, V1
Wang, W2
Makarov, E2
Kharbanda, KK2
Poluektova, LY2
Osna, NA2
Dagur, RS1
Kidambi, S1
Kwon, HJ1
Won, YS1
Park, O1
Chang, B1
Duryee, MJ1
Thiele, GE1
Matsumoto, A1
Singh, S1
Abdelmegeed, MA1
Song, BJ1
Kawamoto, T1
Vasiliou, V1
Thiele, GM1
Gao, B1
Yang, Y2
Wang, H1
Lv, X1
Wang, Q1
Zhao, H1
Yang, F1
Li, J1
Shiraishi, K1
Tsuruya, K1
Anzai, K1
Arase, Y1
Hirose, S1
Kagawa, T1
Mine, T1
Matsuzaki, S1
Millonig, G1
Praun, S1
Netzer, M1
Baumgartner, C1
Dornauer, A1
Mueller, S1
Villinger, J1
Vogel, W1
González-Puertos, VY1
Hernández-Pérez, E1
Nuño-Lámbarri, N1
Ventura-Gallegos, JL1
López-Diázguerrero, NE1
Robles-Díaz, G1
Gutiérrez-Ruiz, MC2
Konigsberg, M1
Lachenmeier, DW1
Schoeberl, K1
Kanteres, F1
Kuballa, T1
Sohnius, EM1
Rehm, J1
Lorenzi, R1
Andrades, ME1
Bortolin, RC1
Nagai, R1
Dal-Pizzol, F1
Moreira, JC1
Szuster-Ciesielska, A1
Plewka, K1
Kandefer-Szerszeń, M1
Svegliati-Baroni, G1
Inagaki, Y1
Rincon-Sanchez, AR1
Else, C1
Saccomanno, S1
Benedetti, A1
Ramirez, F1
Rojkind, M1
Ceni, E1
Crabb, DW1
Foschi, M1
Mello, T1
Tarocchi, M1
Patussi, V1
Moraldi, L1
Moretti, R1
Milani, S1
Surrenti, C1
Galli, A1
Zheng, SM2
Jiang, MD2
Zeng, WZ2
Xu, H2
Wang, YX2
Ma, HD1
Xie, FW1
Zhang, Y2
Qin, JP2
Wu, XL2
Potter, JJ1
Mezey, E1
Hernández, E1
Bucio, L1
Souza, V1
Escobar, MC1
Gómez-Quiroz, LE1
Farfán, B1
Kershenobich, D1
Sun, HP1
Bańkowski, E1
Paradis, V1
Scoazec, JY1
Köllinger, M1
Holstege, A1
Moreau, A1
Feldmann, G1
Bedossa, P1
Leeve, CM1
Zetterman, R1
Kakumu, S1
Leevy, CM3
Lieber, CS3
Teschke, R1
Hasumura, Y1
Decarli, LM1
Bossone, CM1
Strickland, RG1
Miller, JV1
Zetterman, RK1
Uppal, R1
Rosman, A1
Hernández, R1
Baraona, E1
Cobden, I1
Matthewson, K1
Carr, WP1
Dick, WC1
Record, CO1
Skarbek-Gałamon, C1
Gałamon, T1
Sorrell, MF1
Freund, G1
O'Hollaren, P1

Reviews

4 reviews available for acetaldehyde and Liver Cirrhosis

ArticleYear
Is contaminated unrecorded alcohol a health problem in the European Union? A review of existing and methodological outline for future studies.
    Addiction (Abingdon, England), 2011, Volume: 106 Suppl 1

    Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Beverages; Carcinogens; Central Nervous System Depressants

2011
Differences in hepatic and metabolic changes after acute and chronic alcohol consumption.
    Federation proceedings, 1975, Volume: 34, Issue:11

    Topics: Acetaldehyde; Acetates; Acute Disease; Alcohol Oxidoreductases; Alcoholism; Animals; Catalase; Chron

1975
Immunologic reactivity and alcoholic liver disease.
    Bulletin of the New York Academy of Medicine, 1975, Volume: 51, Issue:4

    Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; B-Lymphocytes; Caffeine; Chemical and Drug Ind

1975
Metabolic effects produced by alcohol in the liver and other tissues.
    Advances in internal medicine, 1968, Volume: 14

    Topics: Acetaldehyde; Acetates; Alcoholism; Coenzymes; Deficiency Diseases; Dietary Carbohydrates; Enzymes;

1968

Trials

1 trial available for acetaldehyde and Liver Cirrhosis

ArticleYear
Acetaldehyde concentrations in alveolar air following a standard dose of ethanol in man.
    Journal of lipid research, 1965, Volume: 6, Issue:4

    Topics: Acetaldehyde; Acetone; Adult; Air; Alcoholism; Blood Chemical Analysis; Body Weight; Brain Damage, C

1965

Other Studies

28 other studies available for acetaldehyde and Liver Cirrhosis

ArticleYear
Guizhi Fuling pill attenuates liver fibrosis
    Bioengineered, 2022, Volume: 13, Issue:4

    Topics: Acetaldehyde; Animals; Liver; Liver Cirrhosis; Mice; Signal Transduction; Transforming Growth Factor

2022
Serum IgA levels and IgA/IgG ratio in Alcoholic Liver Disease.
    The Journal of the Association of Physicians of India, 2022, Volume: 70, Issue:4

    Topics: Acetaldehyde; Adult; Alcoholism; Biomarkers; Fatty Liver; Humans; Immunoglobulin A; Immunoglobulin G

2022
Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway.
    International immunopharmacology, 2022, Volume: 113, Issue:Pt A

    Topics: Acetaldehyde; Animals; Ethanol; Hepatic Stellate Cells; Liver Cirrhosis; Mice; Mice, Inbred C57BL; P

2022
Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol.
    International journal of molecular sciences, 2023, Mar-10, Volume: 24, Issue:6

    Topics: Acetaldehyde; Animals; Ethanol; Extracellular Vesicles; Hepatic Stellate Cells; Hepatocytes; HIV Inf

2023
Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease.
    Biomolecules, 2019, 12-10, Volume: 9, Issue:12

    Topics: Acetaldehyde; Animals; Apoptosis; Cell Line; Disease Progression; End Stage Liver Disease; Ethanol;

2019
Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:1

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc

2014
Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs.
    Biochimie, 2015, Volume: 115

    Topics: Acetaldehyde; Adenosine A1 Receptor Antagonists; Animals; Cyclic AMP; Dose-Response Relationship, Dr

2015
Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis.
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2015, Volume: 50, Issue:1

    Topics: Acetaldehyde; Cell Shape; Erythrocytes; Ethanol; Hepatitis C; Humans; Liver Cirrhosis

2015
Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2010, Volume: 15, Issue:4

    Topics: Acetaldehyde; Adult; Aged; Biomarkers; Breath Tests; Butadienes; Ethanol; Fatty Liver; Fatty Liver,

2010
Bcl-2 overexpression in hepatic stellate cell line CFSC-2G, induces a pro-fibrotic state.
    Journal of gastroenterology and hepatology, 2010, Volume: 25, Issue:7

    Topics: Acetaldehyde; Actins; Animals; Cell Line; Cell Proliferation; Cellular Senescence; DNA Replication;

2010
Oxidative damage in the liver of rats treated with glycolaldehyde.
    International journal of toxicology, 2011, Volume: 30, Issue:2

    Topics: Acetaldehyde; Animals; Catalase; Fatty Liver; Glycation End Products, Advanced; Injections, Intraven

2011
Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:5

    Topics: Acetaldehyde; Animals; Antioxidants; Betulinic Acid; Chalcones; Cytokines; Down-Regulation; Hepatic

2011
Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent.
    Hepatology (Baltimore, Md.), 2005, Volume: 42, Issue:2

    Topics: Acetaldehyde; Cells, Cultured; Collagen; Collagen Type I; DNA-Binding Proteins; Humans; Hydrogen Per

2005
Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.
    Gastroenterology, 2006, Volume: 131, Issue:4

    Topics: Acetaldehyde; Animals; Cells, Cultured; Central Nervous System Depressants; Collagen; Ethanol; Extra

2006
Effects of extracellular signal-regulated kinase on rat cultured hepatic stellate cells stimulated by acetaldehyde.
    Journal of digestive diseases, 2007, Volume: 8, Issue:3

    Topics: Acetaldehyde; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cells, Cultured; Co

2007
Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesis.
    Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:12

    Topics: Acetaldehyde; Adiponectin; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Drug Intera

2007
Pentoxifylline downregulates alpha (I) collagen expression by the inhibition of Ikappabalpha degradation in liver stellate cells.
    Cell biology and toxicology, 2008, Volume: 24, Issue:4

    Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Collagen Type I; Electr

2008
An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2008, Volume: 7, Issue:1

    Topics: Acetaldehyde; Animals; Cells, Cultured; Collagen Type I; Cyclin D1; Cyclin-Dependent Kinase 4; Enzym

2008
Collagen in liver fibrosis induced by ethanol.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1994, Volume: 39

    Topics: Acetaldehyde; Animals; Collagen; Ethanol; Humans; Liver Cirrhosis; Liver Cirrhosis, Experimental; Ra

1994
Cellular and subcellular localization of acetaldehyde-protein adducts in liver biopsies from alcoholic patients.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1996, Volume: 44, Issue:9

    Topics: Acetaldehyde; Animals; Biopsy; Cells, Cultured; Cytosol; Endoplasmic Reticulum; Humans; Immunohistoc

1996
Alcoholic hepatitis, cirrhosis, and immunologic reactivity.
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Acetaldehyde; Alcoholism; B-Lymphocytes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Co

1975
Lymphocyte cytotoxicity in alcoholic hepatitis.
    Gastroenterology, 1977, Volume: 72, Issue:4 Pt 1

    Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; Biopsy; Cell Line; Culture Techniques; Cytotox

1977
The liver: a pharmacologic perspective.
    The Nursing clinics of North America, 1977, Volume: 12, Issue:2

    Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec

1977
The pathogenesis of alcoholic hepatitis and cirrhosis.
    Australian and New Zealand journal of medicine, 1976, Volume: 6, Issue:1

    Topics: Acetaldehyde; Alcoholism; Animals; Autoantibodies; Female; Hepatitis; Humans; Immunity, Cellular; Im

1976
Effects of liver disease on red blood cell acetaldehyde in alcoholics and non-alcoholics.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1991, Volume: 1

    Topics: Acetaldehyde; Alcohol Drinking; Erythrocytes; Fatty Liver; Humans; Liver Cirrhosis; Liver Cirrhosis,

1991
Effect of ethanol challenge on serum glycoproteins in alcoholic and non-alcoholic liver disease.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1987, Volume: 22, Issue:3

    Topics: Acetaldehyde; alpha-Macroglobulins; Ethanol; Glycoproteins; Haptoglobins; Humans; Liver Cirrhosis; L

1987
[Various biochemical mechanisms of alcoholic liver cirrhosis].
    Przeglad epidemiologiczny, 1989, Volume: 43, Issue:3

    Topics: Acetaldehyde; Alcoholism; Europe; Free Radicals; Humans; Lipid Peroxides; Liver; Liver Cirrhosis

1989
Lymphocyte transformation and alcoholic liver injury.
    Gastroenterology, 1972, Volume: 63, Issue:6

    Topics: Acetaldehyde; Alcoholism; Cells, Cultured; Chemical and Drug Induced Liver Injury; DNA; Ethanol; Fat

1972