acetaldehyde has been researched along with Liver Cirrhosis in 33 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatic cirrhosis is associated with abnormal red blood cell morphology and function, particularly impaired red blood cell deformability." | 5.42 | Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis. ( Anzai, K; Arase, Y; Hirose, S; Kagawa, T; Matsuzaki, S; Mine, T; Shiraishi, K; Tsuruya, K, 2015) |
| "The risk of liver fibrosis development is potentiated by alcohol abuse." | 1.91 | Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol. ( Ganesan, M; Kanika, S; Kharbanda, KK; Koganti, SS; Kumar, V; Makarov, E; New-Aaron, M; Osna, NA; Poluektova, LY; Wang, W, 2023) |
| "GGT indicates Alcohol Abuse only in background of normal LFT." | 1.72 | Serum IgA levels and IgA/IgG ratio in Alcoholic Liver Disease. ( BhatB, NM, 2022) |
| "24% were in steatosis,32% were in steatohepatitis, while 44% were in cirrhosis." | 1.72 | Serum IgA levels and IgA/IgG ratio in Alcoholic Liver Disease. ( BhatB, NM, 2022) |
| "Alcoholic liver fibrosis（ALF）, as a liver disease caused by long-term alcoholism, attracts international attention." | 1.72 | Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway. ( Li, ZX; Sheng, XD; Wang, YL; Wen Lv, X, 2022) |
| "Hepatic cirrhosis is associated with abnormal red blood cell morphology and function, particularly impaired red blood cell deformability." | 1.42 | Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis. ( Anzai, K; Arase, Y; Hirose, S; Kagawa, T; Matsuzaki, S; Mine, T; Shiraishi, K; Tsuruya, K, 2015) |
| "Butein has also been reported to prevent and partly reverse liver fibrosis in vivo, although its mechanism of action is poorly understood." | 1.37 | Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. ( Kandefer-Szerszeń, M; Plewka, K; Szuster-Ciesielska, A, 2011) |
| "Liver fibrosis has been reported to be inhibited in vivo by oleanolic and ursolic acids; however, the activity of other triterpenes like betulin and betulinic acid has not been examined." | 1.37 | Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. ( Kandefer-Szerszeń, M; Plewka, K; Szuster-Ciesielska, A, 2011) |
| "Acetaldehyde-treated cells pretreated with an anti-IL-6 monoclonal antibody did not show any increase in alpha (I) collagen expression." | 1.35 | Pentoxifylline downregulates alpha (I) collagen expression by the inhibition of Ikappabalpha degradation in liver stellate cells. ( Bucio, L; Escobar, MC; Farfán, B; Gómez-Quiroz, LE; Gutiérrez-Ruiz, MC; Hernández, E; Kershenobich, D; Souza, V, 2008) |
| "Liver fibrosis is accompanied by significant increase of collagen content in this organ." | 1.29 | Collagen in liver fibrosis induced by ethanol. ( Bańkowski, E, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (33.33) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Xu, B | 1 |
| Ding, Y | 1 |
| Ding, X | 1 |
| Yang, Z | 1 |
| BhatB, NM | 1 |
| Li, ZX | 1 |
| Sheng, XD | 1 |
| Wang, YL | 1 |
| Wen Lv, X | 1 |
| New-Aaron, M | 2 |
| Koganti, SS | 1 |
| Ganesan, M | 2 |
| Kanika, S | 1 |
| Kumar, V | 1 |
| Wang, W | 2 |
| Makarov, E | 2 |
| Kharbanda, KK | 2 |
| Poluektova, LY | 2 |
| Osna, NA | 2 |
| Dagur, RS | 1 |
| Kidambi, S | 1 |
| Kwon, HJ | 1 |
| Won, YS | 1 |
| Park, O | 1 |
| Chang, B | 1 |
| Duryee, MJ | 1 |
| Thiele, GE | 1 |
| Matsumoto, A | 1 |
| Singh, S | 1 |
| Abdelmegeed, MA | 1 |
| Song, BJ | 1 |
| Kawamoto, T | 1 |
| Vasiliou, V | 1 |
| Thiele, GM | 1 |
| Gao, B | 1 |
| Yang, Y | 2 |
| Wang, H | 1 |
| Lv, X | 1 |
| Wang, Q | 1 |
| Zhao, H | 1 |
| Yang, F | 1 |
| Li, J | 1 |
| Shiraishi, K | 1 |
| Tsuruya, K | 1 |
| Anzai, K | 1 |
| Arase, Y | 1 |
| Hirose, S | 1 |
| Kagawa, T | 1 |
| Mine, T | 1 |
| Matsuzaki, S | 1 |
| Millonig, G | 1 |
| Praun, S | 1 |
| Netzer, M | 1 |
| Baumgartner, C | 1 |
| Dornauer, A | 1 |
| Mueller, S | 1 |
| Villinger, J | 1 |
| Vogel, W | 1 |
| González-Puertos, VY | 1 |
| Hernández-Pérez, E | 1 |
| Nuño-Lámbarri, N | 1 |
| Ventura-Gallegos, JL | 1 |
| López-Diázguerrero, NE | 1 |
| Robles-Díaz, G | 1 |
| Gutiérrez-Ruiz, MC | 2 |
| Konigsberg, M | 1 |
| Lachenmeier, DW | 1 |
| Schoeberl, K | 1 |
| Kanteres, F | 1 |
| Kuballa, T | 1 |
| Sohnius, EM | 1 |
| Rehm, J | 1 |
| Lorenzi, R | 1 |
| Andrades, ME | 1 |
| Bortolin, RC | 1 |
| Nagai, R | 1 |
| Dal-Pizzol, F | 1 |
| Moreira, JC | 1 |
| Szuster-Ciesielska, A | 1 |
| Plewka, K | 1 |
| Kandefer-Szerszeń, M | 1 |
| Svegliati-Baroni, G | 1 |
| Inagaki, Y | 1 |
| Rincon-Sanchez, AR | 1 |
| Else, C | 1 |
| Saccomanno, S | 1 |
| Benedetti, A | 1 |
| Ramirez, F | 1 |
| Rojkind, M | 1 |
| Ceni, E | 1 |
| Crabb, DW | 1 |
| Foschi, M | 1 |
| Mello, T | 1 |
| Tarocchi, M | 1 |
| Patussi, V | 1 |
| Moraldi, L | 1 |
| Moretti, R | 1 |
| Milani, S | 1 |
| Surrenti, C | 1 |
| Galli, A | 1 |
| Zheng, SM | 2 |
| Jiang, MD | 2 |
| Zeng, WZ | 2 |
| Xu, H | 2 |
| Wang, YX | 2 |
| Ma, HD | 1 |
| Xie, FW | 1 |
| Zhang, Y | 2 |
| Qin, JP | 2 |
| Wu, XL | 2 |
| Potter, JJ | 1 |
| Mezey, E | 1 |
| Hernández, E | 1 |
| Bucio, L | 1 |
| Souza, V | 1 |
| Escobar, MC | 1 |
| Gómez-Quiroz, LE | 1 |
| Farfán, B | 1 |
| Kershenobich, D | 1 |
| Sun, HP | 1 |
| Bańkowski, E | 1 |
| Paradis, V | 1 |
| Scoazec, JY | 1 |
| Köllinger, M | 1 |
| Holstege, A | 1 |
| Moreau, A | 1 |
| Feldmann, G | 1 |
| Bedossa, P | 1 |
| Leeve, CM | 1 |
| Zetterman, R | 1 |
| Kakumu, S | 1 |
| Leevy, CM | 3 |
| Lieber, CS | 3 |
| Teschke, R | 1 |
| Hasumura, Y | 1 |
| Decarli, LM | 1 |
| Bossone, CM | 1 |
| Strickland, RG | 1 |
| Miller, JV | 1 |
| Zetterman, RK | 1 |
| Uppal, R | 1 |
| Rosman, A | 1 |
| Hernández, R | 1 |
| Baraona, E | 1 |
| Cobden, I | 1 |
| Matthewson, K | 1 |
| Carr, WP | 1 |
| Dick, WC | 1 |
| Record, CO | 1 |
| Skarbek-Gałamon, C | 1 |
| Gałamon, T | 1 |
| Sorrell, MF | 1 |
| Freund, G | 1 |
| O'Hollaren, P | 1 |
4 reviews available for acetaldehyde and Liver Cirrhosis
| Article | Year |
|---|---|
Is contaminated unrecorded alcohol a health problem in the European Union? A review of existing and methodological outline for future studies.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Beverages; Carcinogens; Central Nervous System Depressants | 2011 |
Differences in hepatic and metabolic changes after acute and chronic alcohol consumption.
Topics: Acetaldehyde; Acetates; Acute Disease; Alcohol Oxidoreductases; Alcoholism; Animals; Catalase; Chron | 1975 |
Immunologic reactivity and alcoholic liver disease.
Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; B-Lymphocytes; Caffeine; Chemical and Drug Ind | 1975 |
Metabolic effects produced by alcohol in the liver and other tissues.
Topics: Acetaldehyde; Acetates; Alcoholism; Coenzymes; Deficiency Diseases; Dietary Carbohydrates; Enzymes; | 1968 |
1 trial available for acetaldehyde and Liver Cirrhosis
| Article | Year |
|---|---|
Acetaldehyde concentrations in alveolar air following a standard dose of ethanol in man.
Topics: Acetaldehyde; Acetone; Adult; Air; Alcoholism; Blood Chemical Analysis; Body Weight; Brain Damage, C | 1965 |
28 other studies available for acetaldehyde and Liver Cirrhosis
| Article | Year |
|---|---|
Guizhi Fuling pill attenuates liver fibrosis
Topics: Acetaldehyde; Animals; Liver; Liver Cirrhosis; Mice; Signal Transduction; Transforming Growth Factor | 2022 |
Serum IgA levels and IgA/IgG ratio in Alcoholic Liver Disease.
Topics: Acetaldehyde; Adult; Alcoholism; Biomarkers; Fatty Liver; Humans; Immunoglobulin A; Immunoglobulin G | 2022 |
Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway.
Topics: Acetaldehyde; Animals; Ethanol; Hepatic Stellate Cells; Liver Cirrhosis; Mice; Mice, Inbred C57BL; P | 2022 |
Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol.
Topics: Acetaldehyde; Animals; Ethanol; Extracellular Vesicles; Hepatic Stellate Cells; Hepatocytes; HIV Inf | 2023 |
Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease.
Topics: Acetaldehyde; Animals; Apoptosis; Cell Line; Disease Progression; End Stage Liver Disease; Ethanol; | 2019 |
Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc | 2014 |
Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs.
Topics: Acetaldehyde; Adenosine A1 Receptor Antagonists; Animals; Cyclic AMP; Dose-Response Relationship, Dr | 2015 |
Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis.
Topics: Acetaldehyde; Cell Shape; Erythrocytes; Ethanol; Hepatitis C; Humans; Liver Cirrhosis | 2015 |
Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study.
Topics: Acetaldehyde; Adult; Aged; Biomarkers; Breath Tests; Butadienes; Ethanol; Fatty Liver; Fatty Liver, | 2010 |
Bcl-2 overexpression in hepatic stellate cell line CFSC-2G, induces a pro-fibrotic state.
Topics: Acetaldehyde; Actins; Animals; Cell Line; Cell Proliferation; Cellular Senescence; DNA Replication; | 2010 |
Oxidative damage in the liver of rats treated with glycolaldehyde.
Topics: Acetaldehyde; Animals; Catalase; Fatty Liver; Glycation End Products, Advanced; Injections, Intraven | 2011 |
Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells.
Topics: Acetaldehyde; Animals; Antioxidants; Betulinic Acid; Chalcones; Cytokines; Down-Regulation; Hepatic | 2011 |
Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent.
Topics: Acetaldehyde; Cells, Cultured; Collagen; Collagen Type I; DNA-Binding Proteins; Humans; Hydrogen Per | 2005 |
Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.
Topics: Acetaldehyde; Animals; Cells, Cultured; Central Nervous System Depressants; Collagen; Ethanol; Extra | 2006 |
Effects of extracellular signal-regulated kinase on rat cultured hepatic stellate cells stimulated by acetaldehyde.
Topics: Acetaldehyde; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cells, Cultured; Co | 2007 |
Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesis.
Topics: Acetaldehyde; Adiponectin; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Drug Intera | 2007 |
Pentoxifylline downregulates alpha (I) collagen expression by the inhibition of Ikappabalpha degradation in liver stellate cells.
Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Collagen Type I; Electr | 2008 |
An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis.
Topics: Acetaldehyde; Animals; Cells, Cultured; Collagen Type I; Cyclin D1; Cyclin-Dependent Kinase 4; Enzym | 2008 |
Collagen in liver fibrosis induced by ethanol.
Topics: Acetaldehyde; Animals; Collagen; Ethanol; Humans; Liver Cirrhosis; Liver Cirrhosis, Experimental; Ra | 1994 |
Cellular and subcellular localization of acetaldehyde-protein adducts in liver biopsies from alcoholic patients.
Topics: Acetaldehyde; Animals; Biopsy; Cells, Cultured; Cytosol; Endoplasmic Reticulum; Humans; Immunohistoc | 1996 |
Alcoholic hepatitis, cirrhosis, and immunologic reactivity.
Topics: Acetaldehyde; Alcoholism; B-Lymphocytes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Co | 1975 |
Lymphocyte cytotoxicity in alcoholic hepatitis.
Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; Biopsy; Cell Line; Culture Techniques; Cytotox | 1977 |
The liver: a pharmacologic perspective.
Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec | 1977 |
The pathogenesis of alcoholic hepatitis and cirrhosis.
Topics: Acetaldehyde; Alcoholism; Animals; Autoantibodies; Female; Hepatitis; Humans; Immunity, Cellular; Im | 1976 |
Effects of liver disease on red blood cell acetaldehyde in alcoholics and non-alcoholics.
Topics: Acetaldehyde; Alcohol Drinking; Erythrocytes; Fatty Liver; Humans; Liver Cirrhosis; Liver Cirrhosis, | 1991 |
Effect of ethanol challenge on serum glycoproteins in alcoholic and non-alcoholic liver disease.
Topics: Acetaldehyde; alpha-Macroglobulins; Ethanol; Glycoproteins; Haptoglobins; Humans; Liver Cirrhosis; L | 1987 |
[Various biochemical mechanisms of alcoholic liver cirrhosis].
Topics: Acetaldehyde; Alcoholism; Europe; Free Radicals; Humans; Lipid Peroxides; Liver; Liver Cirrhosis | 1989 |
Lymphocyte transformation and alcoholic liver injury.
Topics: Acetaldehyde; Alcoholism; Cells, Cultured; Chemical and Drug Induced Liver Injury; DNA; Ethanol; Fat | 1972 |