acetaldehyde has been researched along with Genetic Predisposition in 26 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible." | 4.87 | Meta-analysis of ALDH2 variants and esophageal cancer in Asians. ( Chen, T; Fang, P; Gao, Y; Jiao, S; Liu, Z; Luo, H; Shi, L; Wang, H; Zhang, X, 2011) |
| "Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible." | 2.47 | Meta-analysis of ALDH2 variants and esophageal cancer in Asians. ( Chen, T; Fang, P; Gao, Y; Jiao, S; Liu, Z; Luo, H; Shi, L; Wang, H; Zhang, X, 2011) |
| "Oral cancer is the sixth most common cancer worldwide and a major health problem in some parts of the world." | 2.46 | Oral cancer and polymorphism of ethanol metabolising genes. ( Acha-Sagredo, A; Aguirre-Urizar, JM; Marichalar-Mendia, X; Rey-Barja, N; Rodriguez-Tojo, MJ, 2010) |
| "Acetaldehyde is an intermediate of ethanol oxidation." | 2.45 | Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. ( Isse, T; Kawamoto, T; Kitakawa, K; Ogawa, M; Oyama, T; Pham, TT; Yu, HS, 2009) |
| "Acetaldehyde itself is a cancer-causing substance in experimental animals and reacts with DNA to form cancer-promoting compounds." | 2.44 | Alcohol metabolism and cancer risk. ( Becker, P; Seitz, HK, 2007) |
| "Associations between alcohol dependence and polymorphisms in ADH1B, ADH1C, and ALDH2 were compared in a community sample of Native Americans (n 791) living on reservations and Mexican Americans (n 391) living within the same county." | 1.38 | ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. ( Ehlers, CL; Gizer, IR; Liang, T, 2012) |
| "No associations between alcohol dependence and polymorphisms in ADH1C were found." | 1.38 | ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. ( Ehlers, CL; Gizer, IR; Liang, T, 2012) |
| "We develop a pharmacokinetic model describing how genetic variations in ADH1B, ADH1C, ADH7, ALDH2, and TAS2R38 affect consumption behavior, and alcohol and acetaldehyde levels over time in various tissues of individuals with a particular genotype to predict their susceptibility to alcohol dependence." | 1.36 | Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. ( Kidd, KK; Miller, P; Mustavich, LF; Zhao, H, 2010) |
| "We describe an approach for alcohol dependence connecting a mechanistic model at the molecular level with disease risk at the population level, and investigate how this model implies statistical gene-gene interactions that affect disease risk." | 1.36 | Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. ( Kidd, KK; Miller, P; Mustavich, LF; Zhao, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 13 (50.00) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Liang, Q | 1 |
| Chen, Y | 1 |
| Cao, Y | 1 |
| Zhuo, Q | 1 |
| Liu, B | 1 |
| Wang, S | 1 |
| Takahashi, T | 1 |
| Miao, Y | 1 |
| Kang, F | 1 |
| Dolai, S | 1 |
| Gaisano, HY | 1 |
| Shiba, S | 1 |
| Nakamoto, N | 1 |
| Chu, PS | 1 |
| Ojiro, K | 1 |
| Taniki, N | 1 |
| Yamaguchi, A | 1 |
| Morikawa, R | 1 |
| Katayama, T | 1 |
| Yoshida, A | 1 |
| Aoki, R | 1 |
| Teratani, T | 1 |
| Suzuki, T | 1 |
| Miyamoto, T | 1 |
| Hara, S | 1 |
| Yokoyama, A | 5 |
| Kanai, T | 1 |
| Kamada, Y | 1 |
| Imazeki, H | 2 |
| Hayashi, E | 1 |
| Murata, S | 1 |
| Kinoshita, K | 1 |
| Yokoyama, T | 3 |
| Kitagawa, Y | 1 |
| Tsutsumi, E | 1 |
| Suwa, Y | 1 |
| Nakamura, C | 1 |
| Mizukami, T | 1 |
| Brooks, PJ | 2 |
| Goldman, D | 2 |
| Li, TK | 3 |
| Enoch, MA | 1 |
| Yu, HS | 1 |
| Oyama, T | 1 |
| Isse, T | 1 |
| Kitakawa, K | 1 |
| Ogawa, M | 1 |
| Pham, TT | 1 |
| Kawamoto, T | 1 |
| Marichalar-Mendia, X | 1 |
| Rodriguez-Tojo, MJ | 1 |
| Acha-Sagredo, A | 1 |
| Rey-Barja, N | 1 |
| Aguirre-Urizar, JM | 1 |
| Linneberg, A | 1 |
| Gonzalez-Quintela, A | 1 |
| Vidal, C | 1 |
| Jørgensen, T | 1 |
| Fenger, M | 1 |
| Hansen, T | 1 |
| Pedersen, O | 1 |
| Husemoen, LL | 1 |
| Mustavich, LF | 1 |
| Miller, P | 1 |
| Kidd, KK | 1 |
| Zhao, H | 1 |
| Omori, T | 1 |
| Latino-Martel, P | 1 |
| Arwidson, P | 1 |
| Ancellin, R | 1 |
| Druesne-Pecollo, N | 1 |
| Hercberg, S | 1 |
| Le Quellec-Nathan, M | 1 |
| Le-Luong, T | 1 |
| Maraninchi, D | 1 |
| Salaspuro, M | 2 |
| Mikko, S | 1 |
| Fang, P | 1 |
| Jiao, S | 1 |
| Zhang, X | 1 |
| Liu, Z | 1 |
| Wang, H | 1 |
| Gao, Y | 1 |
| Luo, H | 1 |
| Chen, T | 1 |
| Shi, L | 1 |
| Ehlers, CL | 1 |
| Liang, T | 1 |
| Gizer, IR | 1 |
| Bushma, MI | 1 |
| Ambrushkevich, YG | 1 |
| Zimatkin, SM | 1 |
| Bushma, KM | 1 |
| Omel'yanchik, SN | 1 |
| Slyshenkov, VS | 1 |
| Mel'nichenko, NG | 1 |
| Kuz'mich, AB | 1 |
| El'chaninova, MA | 1 |
| Ward, RJ | 1 |
| Coutelle, Ch | 1 |
| Brennan, P | 1 |
| Kim, JM | 1 |
| Stewart, R | 1 |
| Shin, IS | 1 |
| Jung, JS | 1 |
| Yoon, JS | 1 |
| Kim, JS | 1 |
| Kim, YJ | 1 |
| Kim, TY | 1 |
| Song, JY | 1 |
| Cho, YH | 1 |
| Park, YC | 1 |
| Chung, HW | 1 |
| Seitz, HK | 2 |
| Savolainen, M | 1 |
| Haber, P | 1 |
| Ishii, H | 1 |
| Teschke, R | 1 |
| Moshage, H | 1 |
| Lieber, CS | 1 |
| Wall, TL | 1 |
| Shea, SH | 1 |
| Luczak, SE | 1 |
| Cook, TA | 1 |
| Carr, LG | 1 |
| Yin, SJ | 2 |
| Peng, GS | 2 |
| Becker, P | 1 |
| Wang, MF | 1 |
| Chen, CY | 1 |
| Luu, SU | 1 |
| Chou, HC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Asian Flushing Syndrome With Topical Alpha Agonists[NCT03497442] | Early Phase 1 | 20 participants (Actual) | Interventional | 2018-07-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for acetaldehyde and Genetic Predisposition
| Article | Year |
|---|---|
Susceptibility Factors and Cellular Mechanisms Underlying Alcoholic Pancreatitis.
Topics: Acetaldehyde; Autophagy; Calcium; Disease Susceptibility; Endoplasmic Reticulum Stress; Ethanol; Exo | 2020 |
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, M | 2009 |
Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinogens; D | 2009 |
Oral cancer and polymorphism of ethanol metabolising genes.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Cytochrome P-450 CYP2E1; Ethanol; Fem | 2010 |
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Al | 2010 |
Interactions of alcohol and tobacco in gastrointestinal cancer.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenas | 2012 |
Meta-analysis of ALDH2 variants and esophageal cancer in Asians.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Allel | 2011 |
Alcohol metabolism and cancer risk.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Induced Disorders; Aldehyde Dehydrogenase; Alleles; Bre | 2007 |
1 trial available for acetaldehyde and Genetic Predisposition
| Article | Year |
|---|---|
Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial | 2008 |
17 other studies available for acetaldehyde and Genetic Predisposition
| Article | Year |
|---|---|
Aldehyde dehydrogenase 2 gene rs671 G>A polymorphism is associated with an increased risk of digestive tract cancer.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Gastrointestinal Neoplasms; G | 2023 |
Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochond | 2021 |
Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial; | 2016 |
Alleles of alcohol and acetaldehyde metabolism genes modulate susceptibility to oesophageal cancer from alcohol consumption.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Alleles; Esophageal Neoplasms; Ethanol; Gene | 2009 |
Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
Topics: Acetaldehyde; Adolescent; Adult; Aged; Alcoholic Beverages; Alcoholism; Aldehyde Dehydrogenase; Alde | 2010 |
Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Alcohols; Aldehyde Dehydrogenase; | 2010 |
Alcohol consumption and cancer risk: revisiting guidelines for sensible drinking.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Central Nervous System Depressants; Dose-Response Relati | 2011 |
ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogena | 2012 |
LPO and ethanol biotransformation systems in the liver as markers of predisposition to ethanol hepatotoxicity.
Topics: Acetaldehyde; Alanine Transaminase; Animals; Ascorbic Acid; Biomarkers; Biotransformation; Ethanol; | 2002 |
Women and alcohol susceptibility: could differences in alcohol metabolism predispose women to alcohol-related diseases?
Topics: Acetaldehyde; Adult; Alcoholism; Ethanol; Female; Gene Frequency; Genetic Predisposition to Disease; | 2003 |
Commentary: Mendelian randomization and gene-environment interaction.
Topics: Acetaldehyde; Alcohol Drinking; Behavior; Causality; Diet; Environment; Genetic Predisposition to Di | 2004 |
Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
Topics: Acetaldehyde; Age Factors; Aged; Aging; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehy | 2004 |
Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial | 2005 |
From alcohol toxicity to treatment.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Related Disorders; Alcoholism; Alleles; Cholestasis, In | 2005 |
Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Alleles; Female; Genetic P | 2005 |
Acetaldehyde, polymorphisms and the cardiovascular system.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mit | 2007 |
Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Alleles; Area Under Curve | 1999 |