Page last updated: 2024-10-16

acetaldehyde and Genetic Predisposition

acetaldehyde has been researched along with Genetic Predisposition in 26 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Research Excerpts

ExcerptRelevanceReference
"Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible."4.87Meta-analysis of ALDH2 variants and esophageal cancer in Asians. ( Chen, T; Fang, P; Gao, Y; Jiao, S; Liu, Z; Luo, H; Shi, L; Wang, H; Zhang, X, 2011)
"Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible."2.47Meta-analysis of ALDH2 variants and esophageal cancer in Asians. ( Chen, T; Fang, P; Gao, Y; Jiao, S; Liu, Z; Luo, H; Shi, L; Wang, H; Zhang, X, 2011)
"Oral cancer is the sixth most common cancer worldwide and a major health problem in some parts of the world."2.46Oral cancer and polymorphism of ethanol metabolising genes. ( Acha-Sagredo, A; Aguirre-Urizar, JM; Marichalar-Mendia, X; Rey-Barja, N; Rodriguez-Tojo, MJ, 2010)
"Acetaldehyde is an intermediate of ethanol oxidation."2.45Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. ( Isse, T; Kawamoto, T; Kitakawa, K; Ogawa, M; Oyama, T; Pham, TT; Yu, HS, 2009)
"Acetaldehyde itself is a cancer-causing substance in experimental animals and reacts with DNA to form cancer-promoting compounds."2.44Alcohol metabolism and cancer risk. ( Becker, P; Seitz, HK, 2007)
"Associations between alcohol dependence and polymorphisms in ADH1B, ADH1C, and ALDH2 were compared in a community sample of Native Americans (n 791) living on reservations and Mexican Americans (n 391) living within the same county."1.38ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. ( Ehlers, CL; Gizer, IR; Liang, T, 2012)
"No associations between alcohol dependence and polymorphisms in ADH1C were found."1.38ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. ( Ehlers, CL; Gizer, IR; Liang, T, 2012)
"We develop a pharmacokinetic model describing how genetic variations in ADH1B, ADH1C, ADH7, ALDH2, and TAS2R38 affect consumption behavior, and alcohol and acetaldehyde levels over time in various tissues of individuals with a particular genotype to predict their susceptibility to alcohol dependence."1.36Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. ( Kidd, KK; Miller, P; Mustavich, LF; Zhao, H, 2010)
"We describe an approach for alcohol dependence connecting a mechanistic model at the molecular level with disease risk at the population level, and investigate how this model implies statistical gene-gene interactions that affect disease risk."1.36Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. ( Kidd, KK; Miller, P; Mustavich, LF; Zhao, H, 2010)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.85)18.2507
2000's13 (50.00)29.6817
2010's9 (34.62)24.3611
2020's3 (11.54)2.80

Authors

AuthorsStudies
Yang, Y1
Liang, Q1
Chen, Y1
Cao, Y1
Zhuo, Q1
Liu, B1
Wang, S1
Takahashi, T1
Miao, Y1
Kang, F1
Dolai, S1
Gaisano, HY1
Shiba, S1
Nakamoto, N1
Chu, PS1
Ojiro, K1
Taniki, N1
Yamaguchi, A1
Morikawa, R1
Katayama, T1
Yoshida, A1
Aoki, R1
Teratani, T1
Suzuki, T1
Miyamoto, T1
Hara, S1
Yokoyama, A5
Kanai, T1
Kamada, Y1
Imazeki, H2
Hayashi, E1
Murata, S1
Kinoshita, K1
Yokoyama, T3
Kitagawa, Y1
Tsutsumi, E1
Suwa, Y1
Nakamura, C1
Mizukami, T1
Brooks, PJ2
Goldman, D2
Li, TK3
Enoch, MA1
Yu, HS1
Oyama, T1
Isse, T1
Kitakawa, K1
Ogawa, M1
Pham, TT1
Kawamoto, T1
Marichalar-Mendia, X1
Rodriguez-Tojo, MJ1
Acha-Sagredo, A1
Rey-Barja, N1
Aguirre-Urizar, JM1
Linneberg, A1
Gonzalez-Quintela, A1
Vidal, C1
Jørgensen, T1
Fenger, M1
Hansen, T1
Pedersen, O1
Husemoen, LL1
Mustavich, LF1
Miller, P1
Kidd, KK1
Zhao, H1
Omori, T1
Latino-Martel, P1
Arwidson, P1
Ancellin, R1
Druesne-Pecollo, N1
Hercberg, S1
Le Quellec-Nathan, M1
Le-Luong, T1
Maraninchi, D1
Salaspuro, M2
Mikko, S1
Fang, P1
Jiao, S1
Zhang, X1
Liu, Z1
Wang, H1
Gao, Y1
Luo, H1
Chen, T1
Shi, L1
Ehlers, CL1
Liang, T1
Gizer, IR1
Bushma, MI1
Ambrushkevich, YG1
Zimatkin, SM1
Bushma, KM1
Omel'yanchik, SN1
Slyshenkov, VS1
Mel'nichenko, NG1
Kuz'mich, AB1
El'chaninova, MA1
Ward, RJ1
Coutelle, Ch1
Brennan, P1
Kim, JM1
Stewart, R1
Shin, IS1
Jung, JS1
Yoon, JS1
Kim, JS1
Kim, YJ1
Kim, TY1
Song, JY1
Cho, YH1
Park, YC1
Chung, HW1
Seitz, HK2
Savolainen, M1
Haber, P1
Ishii, H1
Teschke, R1
Moshage, H1
Lieber, CS1
Wall, TL1
Shea, SH1
Luczak, SE1
Cook, TA1
Carr, LG1
Yin, SJ2
Peng, GS2
Becker, P1
Wang, MF1
Chen, CY1
Luu, SU1
Chou, HC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Asian Flushing Syndrome With Topical Alpha Agonists[NCT03497442]Early Phase 120 participants (Actual)Interventional2018-07-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for acetaldehyde and Genetic Predisposition

ArticleYear
Susceptibility Factors and Cellular Mechanisms Underlying Alcoholic Pancreatitis.
    Alcoholism, clinical and experimental research, 2020, Volume: 44, Issue:4

    Topics: Acetaldehyde; Autophagy; Calcium; Disease Susceptibility; Endoplasmic Reticulum Stress; Ethanol; Exo

2020
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption.
    PLoS medicine, 2009, Mar-24, Volume: 6, Issue:3

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, M

2009
Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.
    Toxicology mechanisms and methods, 2009, Volume: 19, Issue:9

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinogens; D

2009
Oral cancer and polymorphism of ethanol metabolising genes.
    Oral oncology, 2010, Volume: 46, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Cytochrome P-450 CYP2E1; Ethanol; Fem

2010
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
    The Keio journal of medicine, 2010, Volume: 59, Issue:4

    Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Al

2010
Interactions of alcohol and tobacco in gastrointestinal cancer.
    Journal of gastroenterology and hepatology, 2012, Volume: 27 Suppl 2

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenas

2012
Meta-analysis of ALDH2 variants and esophageal cancer in Asians.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:10

    Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Allel

2011
Alcohol metabolism and cancer risk.
    Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2007, Volume: 30, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Induced Disorders; Aldehyde Dehydrogenase; Alleles; Bre

2007

Trials

1 trial available for acetaldehyde and Genetic Predisposition

ArticleYear
Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.
    Alcoholism, clinical and experimental research, 2008, Volume: 32, Issue:9

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial

2008

Other Studies

17 other studies available for acetaldehyde and Genetic Predisposition

ArticleYear
Aldehyde dehydrogenase 2 gene rs671 G>A polymorphism is associated with an increased risk of digestive tract cancer.
    The Journal of international medical research, 2023, Volume: 51, Issue:10

    Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Gastrointestinal Neoplasms; G

2023
Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption.
    Scientific reports, 2021, 07-01, Volume: 11, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochond

2021
Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:6

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial;

2016
Alleles of alcohol and acetaldehyde metabolism genes modulate susceptibility to oesophageal cancer from alcohol consumption.
    Human genomics, 2009, Volume: 3, Issue:2

    Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Alleles; Esophageal Neoplasms; Ethanol; Gene

2009
Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2010, Volume: 40, Issue:1

    Topics: Acetaldehyde; Adolescent; Adult; Aged; Alcoholic Beverages; Alcoholism; Aldehyde Dehydrogenase; Alde

2010
Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes.
    Human heredity, 2010, Volume: 70, Issue:3

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Alcohols; Aldehyde Dehydrogenase;

2010
Alcohol consumption and cancer risk: revisiting guidelines for sensible drinking.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2011, Nov-08, Volume: 183, Issue:16

    Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Central Nervous System Depressants; Dose-Response Relati

2011
ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans.
    The American journal of drug and alcohol abuse, 2012, Volume: 38, Issue:5

    Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogena

2012
LPO and ethanol biotransformation systems in the liver as markers of predisposition to ethanol hepatotoxicity.
    Bulletin of experimental biology and medicine, 2002, Volume: 134, Issue:6

    Topics: Acetaldehyde; Alanine Transaminase; Animals; Ascorbic Acid; Biomarkers; Biotransformation; Ethanol;

2002
Women and alcohol susceptibility: could differences in alcohol metabolism predispose women to alcohol-related diseases?
    Archives of women's mental health, 2003, Volume: 6, Issue:4

    Topics: Acetaldehyde; Adult; Alcoholism; Ethanol; Female; Gene Frequency; Genetic Predisposition to Disease;

2003
Commentary: Mendelian randomization and gene-environment interaction.
    International journal of epidemiology, 2004, Volume: 33, Issue:1

    Topics: Acetaldehyde; Alcohol Drinking; Behavior; Causality; Diet; Environment; Genetic Predisposition to Di

2004
Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
    Neurobiology of aging, 2004, Volume: 25, Issue:3

    Topics: Acetaldehyde; Age Factors; Aged; Aging; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehy

2004
Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake.
    Toxicology, 2005, Jun-01, Volume: 210, Issue:2-3

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial

2005
From alcohol toxicity to treatment.
    Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:7

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Related Disorders; Alcoholism; Alleles; Cholestasis, In

2005
Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students.
    Journal of abnormal psychology, 2005, Volume: 114, Issue:3

    Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Alleles; Female; Genetic P

2005
Acetaldehyde, polymorphisms and the cardiovascular system.
    Novartis Foundation symposium, 2007, Volume: 285

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mit

2007
Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.
    Pharmacogenetics, 1999, Volume: 9, Issue:4

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Alleles; Area Under Curve

1999