acetaldehyde has been researched along with Experimental Hepatoma in 9 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Data presented show that antialcohol drugs that inhibit Aldh2 gene expression can be generated endogenously in liver cells infected by an adenoviral vector carrying an antisense-coding gene, thus mimicking the high-acetaldehyde phenotype that exists in humans carrying the Glu487Lys mutation who are protected against alcoholism." | 3.73 | Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA. ( Israel, Y; Karahanian, E; Ocaranza, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karahanian, E | 1 |
| Ocaranza, P | 1 |
| Israel, Y | 2 |
| Canuto, RA | 1 |
| Garcea, R | 1 |
| Biocca, M | 1 |
| Pascale, R | 1 |
| Pirisi, L | 1 |
| Feo, F | 1 |
| Sessa, A | 1 |
| Desiderio, MA | 1 |
| Baizini, M | 1 |
| Perin, A | 1 |
| Nakajima, M | 1 |
| Kato, J | 1 |
| Kohgo, Y | 1 |
| Katsuki, S | 1 |
| Inui, N | 1 |
| Ohya, M | 1 |
| Takeichi, N | 1 |
| Niitu, Y | 1 |
| Cho, KJ | 1 |
| Jang, JJ | 1 |
| Clemens, DL | 1 |
| Casey, CA | 1 |
| Sorrell, MF | 1 |
| Tuma, DJ | 1 |
| Garver, E | 1 |
| Cao, QN | 1 |
| Aini, M | 1 |
| Zhou, F | 1 |
| Daniel, FB | 1 |
| DeAngelo, AB | 1 |
| Stober, JA | 1 |
| Olson, GR | 1 |
| Page, NP | 1 |
| Higgins, PJ | 1 |
| Borenfreund, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for acetaldehyde and Experimental Hepatoma
| Article | Year |
|---|---|
Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA.
Topics: Acetaldehyde; Adenoviridae; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondria | 2005 |
The subcellular distribution and properties of aldehyde dehydrogenase of hepatoma AH-130.
Topics: Acetaldehyde; Aldehyde Oxidoreductases; Animals; Ditiocarb; Isoenzymes; Liver; Liver Neoplasms, Expe | 1983 |
Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Amine Oxidase (Copper-Containing); A | 1981 |
Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Animals; Cell Transformatio | 1993 |
Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Acetaldehyde; Animals; Animals, Newborn; Body Weight; Carbon Tetrachloride; Diethylnitrosamine; Etha | 1993 |
Ethanol oxidation mediates impaired hepatic receptor-mediated enocytosis.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Animals; Asialoglycoprotein Receptor; Cell Line, Transformed; E | 1998 |
Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Anima | 2001 |
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse.
Topics: Acetaldehyde; Animals; Body Weight; Carcinogens; Chloral Hydrate; Dichloroacetic Acid; Drinking Beha | 1992 |
Incubation of rat hepatic tumor cells with ethanol and acetaldehyde in vitro: effects on growth rate, albumin secretion and cellular protein content.
Topics: Acetaldehyde; Albumins; Animals; Cell Division; Cell Line; Ethanol; Liver; Liver Neoplasms, Experime | 1986 |