acetaldehyde has been researched along with Esophageal Neoplasms in 25 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the "acetaldehyde burst," generated shortly upon ethanol intake, as the mechanism of protection against alcoholism conferred by the ADH1B*2 polymorphism." | 8.87 | Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? ( Israel, Y; Quintanilla, ME; Rivera-Meza, M; Sapag, A; Tampier, L, 2011) |
| "Patients with inactive acetaldehyde dehydrogenase 2 (ALDH2) are at high risk for esophageal squamous cell carcinoma (ESCC) and hypopharyngeal squamous cell carcinoma (HPSCC)." | 5.41 | Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma. ( Arima, S; Fujita, H; Hashimoto, S; Ido, A; Iwaya, H; Kabayama, M; Kanmura, S; Komaki, Y; Maeda, H; Oda, K; Sasaki, F; Tanoue, S, 2021) |
| "This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the "acetaldehyde burst," generated shortly upon ethanol intake, as the mechanism of protection against alcoholism conferred by the ADH1B*2 polymorphism." | 4.87 | Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? ( Israel, Y; Quintanilla, ME; Rivera-Meza, M; Sapag, A; Tampier, L, 2011) |
| "Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible." | 4.87 | Meta-analysis of ALDH2 variants and esophageal cancer in Asians. ( Chen, T; Fang, P; Gao, Y; Jiao, S; Liu, Z; Luo, H; Shi, L; Wang, H; Zhang, X, 2011) |
| "The acetaldehyde-to-ethanol ratio detected using the acetaldehyde breath test could be a novel biomarker of metachronous recurrence after endoscopic submucosal dissection in patients with esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma." | 4.31 | Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma. ( Arima, S; Hashimoto, S; Ido, A; Kanmura, S; Kumagai, K; Maeda, H; Mawatari, S; Oda, K; Sasaki, F; Tanaka, A; Tanoue, S; Yano, H, 2023) |
| "Alcohol consumption is the key risk factor for the development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major carcinogen that causes DNA damage." | 3.96 | Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice. ( Amanuma, Y; Baba, K; Hirohashi, K; Ida, T; Kikuchi, O; Matsubara, J; Matsuda, T; Mitani, Y; Miyamoto, S; Mizumoto, A; Muto, M; Nakai, Y; Ohashi, S; Seno, H; Yamada, A; Yamamoto, Y, 2020) |
| "Esophageal squamous cell carcinoma (ESCC) accounts for the large majority of esophageal cancer cases worldwide." | 2.82 | Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma. ( Abrams, JA; Etemadi, A; Soroush, A, 2022) |
| "Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible." | 2.47 | Meta-analysis of ALDH2 variants and esophageal cancer in Asians. ( Chen, T; Fang, P; Gao, Y; Jiao, S; Liu, Z; Luo, H; Shi, L; Wang, H; Zhang, X, 2011) |
| "Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon." | 1.72 | Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. ( Abe, H; Asano, N; Asanuma, K; Hamada, S; Hatta, W; Imatani, A; Jin, X; Kanno, T; Koike, T; Masamune, A; Nakamura, T; Nakaya, N; Ogata, Y; Ono, Y; Saito, M; Toda, S; Uno, K, 2022) |
| "Acetaldehyde is a potential carcinogen for esophageal cancer, and some oral microorganisms produce acetaldehyde from ethanol or glucose." | 1.51 | Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study. ( Akazawa, K; Kamei, T; Koseki, T; Takahashi, N; Tanda, N; Washio, J, 2019) |
| "Samples were taken from 21 esophageal cancer patients (median age 68 years) and 20 age-matched healthy volunteers (control group) before and after oral care." | 1.51 | Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study. ( Akazawa, K; Kamei, T; Koseki, T; Takahashi, N; Tanda, N; Washio, J, 2019) |
| "Esophageal cancer is unusually frequent in Western Kenya, despite the low prevalence of classical risk factors such as heavy drinking and tobacco smoking." | 1.39 | Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya. ( Abnet, CC; Bowyer, P; Collins, R; Dawsey, SM; Dawsey, SP; Freedman, ND; Mwachiro, M; Nieminen, MT; Novak-Frazer, L; Rautemaa, R; Salaspuro, M; White, RE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 6 (24.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, Y | 1 |
| Karaoz, U | 1 |
| Yang, L | 1 |
| Yachimski, PS | 1 |
| Tseng, W | 1 |
| Nossa, CW | 1 |
| Ye, W | 1 |
| Tseng, M | 1 |
| Poles, M | 1 |
| Francois, F | 1 |
| Traube, M | 1 |
| Brown, SM | 1 |
| Chen, Y | 1 |
| Torralba, M | 1 |
| Peek, RM | 1 |
| Brodie, EL | 1 |
| Pei, Z | 1 |
| Toda, S | 1 |
| Hatta, W | 2 |
| Asanuma, K | 2 |
| Asano, N | 2 |
| Ono, Y | 1 |
| Abe, H | 1 |
| Ogata, Y | 1 |
| Saito, M | 1 |
| Kanno, T | 1 |
| Jin, X | 1 |
| Uno, K | 1 |
| Koike, T | 2 |
| Imatani, A | 1 |
| Hamada, S | 2 |
| Nakamura, T | 1 |
| Nakaya, N | 1 |
| Masamune, A | 2 |
| Sasaki, F | 2 |
| Mawatari, S | 1 |
| Oda, K | 2 |
| Yano, H | 1 |
| Maeda, H | 2 |
| Tanaka, A | 1 |
| Arima, S | 2 |
| Kumagai, K | 1 |
| Tanoue, S | 2 |
| Hashimoto, S | 2 |
| Kanmura, S | 2 |
| Ido, A | 2 |
| Tanda, N | 1 |
| Washio, J | 1 |
| Kamei, T | 1 |
| Akazawa, K | 1 |
| Takahashi, N | 1 |
| Koseki, T | 1 |
| Kabayama, M | 1 |
| Iwaya, H | 1 |
| Komaki, Y | 1 |
| Fujita, H | 1 |
| Soroush, A | 1 |
| Etemadi, A | 1 |
| Abrams, JA | 1 |
| Matejcic, M | 1 |
| Gunter, MJ | 1 |
| Ferrari, P | 1 |
| Mizumoto, A | 2 |
| Ohashi, S | 2 |
| Hirohashi, K | 2 |
| Amanuma, Y | 2 |
| Matsuda, T | 2 |
| Muto, M | 2 |
| Okata, H | 1 |
| Iijima, K | 1 |
| Tsuruya, A | 1 |
| Nakayama, T | 1 |
| Shimosegawa, T | 1 |
| Nakai, Y | 1 |
| Ida, T | 1 |
| Baba, K | 1 |
| Mitani, Y | 1 |
| Yamamoto, Y | 1 |
| Kikuchi, O | 1 |
| Matsubara, J | 1 |
| Yamada, A | 1 |
| Miyamoto, S | 1 |
| Seno, H | 1 |
| Brooks, PJ | 2 |
| Goldman, D | 2 |
| Li, TK | 2 |
| Enoch, MA | 1 |
| Yokoyama, A | 4 |
| Lee, CH | 1 |
| Wu, DC | 1 |
| Wu, IC | 1 |
| Goan, YG | 1 |
| Lee, JM | 1 |
| Chou, SH | 1 |
| Chan, TF | 1 |
| Huang, HL | 1 |
| Hung, YH | 1 |
| Huang, MC | 1 |
| Lai, TC | 1 |
| Wang, TN | 1 |
| Lan, CC | 1 |
| Tsai, S | 1 |
| Lin, WY | 1 |
| Wu, MT | 1 |
| Omori, T | 2 |
| Yokoyama, T | 1 |
| Lachenmeier, DW | 1 |
| Monakhova, YB | 1 |
| Israel, Y | 1 |
| Rivera-Meza, M | 1 |
| Quintanilla, ME | 1 |
| Sapag, A | 1 |
| Tampier, L | 1 |
| Fang, P | 1 |
| Jiao, S | 1 |
| Zhang, X | 1 |
| Liu, Z | 1 |
| Wang, H | 1 |
| Gao, Y | 1 |
| Luo, H | 1 |
| Chen, T | 1 |
| Shi, L | 1 |
| Nieminen, MT | 1 |
| Novak-Frazer, L | 1 |
| Collins, R | 1 |
| Dawsey, SP | 1 |
| Dawsey, SM | 1 |
| Abnet, CC | 1 |
| White, RE | 1 |
| Freedman, ND | 1 |
| Mwachiro, M | 1 |
| Bowyer, P | 1 |
| Salaspuro, M | 2 |
| Rautemaa, R | 1 |
| Lukaschek, J | 1 |
| Nufer, M | 1 |
| Maurer, D | 1 |
| Asanger, M | 1 |
| Honegger, H | 1 |
| Widmer, L | 1 |
| Malet-Martino, M | 1 |
| Legay, R | 1 |
| Martino, R | 1 |
| Lewis, SJ | 1 |
| Smith, GD | 1 |
| Linderborg, K | 1 |
| Joly, JP | 1 |
| Visapää, JP | 1 |
| Paget, V | 1 |
| Lechevrel, M | 1 |
| Sichel, F | 1 |
| Muramatsu, T | 1 |
| Ohmori, T | 1 |
| Higuchi, S | 1 |
| Hayashida, M | 1 |
| Ishii, H | 1 |
| Noori, P | 1 |
| Hou, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement[NCT05261620] | 132 participants (Anticipated) | Interventional | 2022-12-12 | Recruiting | |||
| Treatment of Asian Flushing Syndrome With Topical Alpha Agonists[NCT03497442] | Early Phase 1 | 20 participants (Actual) | Interventional | 2018-07-12 | Completed | ||
| The THINKER Study: A Pilot for a Case-Control of Esophageal Squamous Cell Carcinoma in Western Kenya[NCT00901173] | 372 participants (Actual) | Observational | 2014-02-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for acetaldehyde and Esophageal Neoplasms
| Article | Year |
|---|---|
Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Esophageal Squamous Cell Carc | 2022 |
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Biomarkers, Tumor; Carcinoma, Squamous Cell; | 2017 |
Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.
Topics: Acetaldehyde; Animals; Carcinogenesis; Carcinoma, Squamous Cell; DNA Damage; Esophageal Neoplasms; E | 2017 |
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, M | 2009 |
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Al | 2010 |
Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption?
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Animals; | 2011 |
Meta-analysis of ALDH2 variants and esophageal cancer in Asians.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Allel | 2011 |
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Animals; Carcinogens; | 2005 |
Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Esophageal Neoplasms; Ethanol; Genotype; Humans; Male; Random A | 2005 |
1 trial available for acetaldehyde and Esophageal Neoplasms
| Article | Year |
|---|---|
Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breath Tests; Carcinoma, Squamous C | 2021 |
15 other studies available for acetaldehyde and Esophageal Neoplasms
| Article | Year |
|---|---|
Progressive dysbiosis of human orodigestive microbiota along the sequence of gastroesophageal reflux, Barrett's esophagus and esophageal adenocarcinoma.
Topics: Acetaldehyde; Adenocarcinoma; Anti-Bacterial Agents; Barrett Esophagus; Case-Control Studies; Dysbio | 2022 |
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; Carcinoma, Squamous Cell; Claud | 2022 |
Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma.
Topics: Acetaldehyde; Aldehydes; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Ethanol; Head and | 2023 |
Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study.
Topics: Acetaldehyde; Aged; Bacteria; Breath Tests; Carcinogens; Case-Control Studies; Esophageal Neoplasms; | 2019 |
Detection of Acetaldehyde in the Esophageal Tissue among Healthy Male Subjects after Ethanol Drinking and Subsequent L-Cysteine Intake.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehyd | 2018 |
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Animals; Benzamides; Benzodio | 2020 |
Alleles of alcohol and acetaldehyde metabolism genes modulate susceptibility to oesophageal cancer from alcohol consumption.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase; Alleles; Esophageal Neoplasms; Ethanol; Gene | 2009 |
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehy | 2009 |
Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism.
Topics: Acetaldehyde; Adult; Alcoholic Beverages; Esophageal Neoplasms; Ethanol; Female; Humans; Male; Risk | 2011 |
Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya.
Topics: Acetaldehyde; Animals; Candida; Carcinoma, Squamous Cell; Colony Count, Microbial; Developing Countr | 2013 |
Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials.
Topics: Acetaldehyde; Aged; Antimetabolites, Antineoplastic; Brain Diseases; Carcinoma; Chemistry, Pharmaceu | 2004 |
Potential mechanism for Calvados-related oesophageal cancer.
Topics: Acetaldehyde; Alcoholic Beverages; Esophageal Neoplasms; Ethanol; France; Humans; Solvents; Wine | 2008 |
Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast).
Topics: Acetaldehyde; Alcohol Drinking; Alleles; Carcinoma, Squamous Cell; Cells, Cultured; DNA Mutational A | 2008 |
Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; | 1996 |
Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers.
Topics: Acetaldehyde; DNA Mutational Analysis; DNA Primers; DNA, Complementary; Esophageal Neoplasms; Exons; | 2001 |