acetaldehyde has been researched along with Disease Models, Animal in 71 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effects of a low concentration of acetaldehyde, which itself did not trigger airway inflammation, on extant allergic airway inflammation in a murine model of allergic asthma." | 7.78 | Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Nishino, T; Tsuchida, T, 2012) |
| "Exposure to acetaldehyde can enhance allergic airway inflammation in asthma." | 7.78 | Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Nishino, T; Tsuchida, T, 2012) |
| "Acetaldehyde is an endocrine-disrupting chemical (EDC) and a volatile organic compound (VOC)." | 5.38 | Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Nishino, T; Tsuchida, T, 2012) |
| "To explore the role of acetaldehyde in alcoholic cardiomyopathy, we generated transgenic mice with overexpression of the alcohol-metabolizing enzyme alcohol dehydrogenase (ADH) and the acetaldehyde-metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2), driven by myosin heavy chain and chicken beta-actin promoters, respectively." | 5.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| "Alcoholic cardiomyopathy is manifested as ventricular dysfunction although its pathogenesis remains obscure." | 5.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| "To determine the effects of a low concentration of acetaldehyde, which itself did not trigger airway inflammation, on extant allergic airway inflammation in a murine model of allergic asthma." | 3.78 | Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Nishino, T; Tsuchida, T, 2012) |
| "Exposure to acetaldehyde can enhance allergic airway inflammation in asthma." | 3.78 | Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Nishino, T; Tsuchida, T, 2012) |
| ", testicular hypogonadism (hypospermatogensis and impotence) induced by warm water treatment, intoxication of acetaldehyde and growth of inoculated tumor cells." | 3.71 | Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. ( Itakura, Y; Kasuga, S; Kyo, E; Morihara, N; Uda, N; Ushijima, M, 2001) |
| "With the ex vivo perfused canine pancreas preparation, the infusion of acetaldehyde, the primary metabolite of ethanol oxidation, plus a short period of ischemia to convert xanthine dehydrogenase to xanthine oxidase, results in the physiologic injury response of acute pancreatitis (edema, weight gain, hyperamylasemia)." | 3.69 | Detailed characterization of experimental acute alcoholic pancreatitis. ( Cameron, JL; Chacko, VP; Nordback, IH; Olson, JL, 1995) |
| "Vinyl acetate monomer (VAM) is a site-of-contact carcinogen in rodents." | 2.49 | Vinyl acetate monomer (VAM) genotoxicity profile: relevance for carcinogenicity. ( Albertini, RJ, 2013) |
| "Inflammation is known to induce oxidative stress, which can lead to lipid peroxidation." | 1.62 | Malondialdehyde-Acetaldehyde Modified (MAA) Proteins Differentially Effect the Inflammatory Response in Macrophage, Endothelial Cells and Animal Models of Cardiovascular Disease. ( Anderson, DR; Clemens, DL; Duryee, LM; Duryee, MJ; Garvin, RP; Opperman, PJ; Thiele, GM, 2021) |
| "Treatment of periodontitis has beneficial effects on systemic inflammation markers that relate to progression of atherosclerosis." | 1.48 | Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein. ( Akhi, R; Hörkkö, S; Kankaanpää, J; Kummu, O; Kyrklund, M; Nissinen, A; Pussinen, P; Turunen, SP; Wang, C, 2018) |
| "Acetaldehyde is an endocrine-disrupting chemical (EDC) and a volatile organic compound (VOC)." | 1.38 | Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Nishino, T; Tsuchida, T, 2012) |
| "However, mechanism of alcoholic pancreatitis remains obscure due to lack of a suitable animal model." | 1.36 | Pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice after subchronic exposure to ethanol. ( Ansari, GA; Bhopale, KK; Boor, PJ; Kaphalia, BS; Kondraganti, S; Wu, H, 2010) |
| " Despite this, none of the adverse effects of 0." | 1.35 | In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro. ( Baverel, G; Dubourg, L; Michoudet, C; Yaseen, Z, 2008) |
| "To explore the role of acetaldehyde in alcoholic cardiomyopathy, we generated transgenic mice with overexpression of the alcohol-metabolizing enzyme alcohol dehydrogenase (ADH) and the acetaldehyde-metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2), driven by myosin heavy chain and chicken beta-actin promoters, respectively." | 1.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| "Alcoholic cardiomyopathy is manifested as ventricular dysfunction although its pathogenesis remains obscure." | 1.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| " These studies have implications for understanding the brain mechanisms involved in mediating the ascending limb of the biphasic dose-response curve for the effect of ethanol on locomotor activity." | 1.33 | Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde. ( Aragon, CM; Arizzi-LaFrance, MN; Correa, M; Salamone, JD, 2006) |
| "Acetaldehyde treatment of H4IIE cells led to a time- and dose-dependent increase in GCLC mRNA levels, binding of NF-kappaB and AP-1 to the GCLC promoter, and luciferase activity driven by the GCLC promoter fragment containing these binding sites." | 1.31 | Cloning and characterization of the 5'-flanking region of the rat glutamate-cysteine ligase catalytic subunit. ( Huang, ZZ; Lu, SC; Ou, X; Wang, J; Yang, H, 2001) |
| "Acetaldehyde adducts were found by immunofluorescence in the centrilobular region and were focused in perivenous zone 3 of all ethanol-fed animals." | 1.29 | Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. ( Chandler, CJ; Halsted, CH; Munn, RJ; Niemelä, O; Parkkila, S; Ruebner, B; Villanueva, J, 1993) |
| " The data indicate that, for administration of this ethanol dosage regimen to the third-trimester pregnant ewe, there is rapid, bidirectional placental transfer of ethanol; elimination of ethanol from the fetus is regulated primarily by maternal elimination of ethanol; the amniotic fluid may serve as a reservoir for ethanol in utero; and there is appreciable acetaldehyde-metabolizing capacity." | 1.27 | Disposition of ethanol in maternal blood, fetal blood, and amniotic fluid of third-trimester pregnant ewes. ( Brien, JF; Clarke, DW; Patrick, J; Richardson, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (18.31) | 18.7374 |
| 1990's | 13 (18.31) | 18.2507 |
| 2000's | 19 (26.76) | 29.6817 |
| 2010's | 21 (29.58) | 24.3611 |
| 2020's | 5 (7.04) | 2.80 |
| Authors | Studies |
|---|---|
| Duryee, MJ | 7 |
| Clemens, DL | 1 |
| Opperman, PJ | 1 |
| Thiele, GM | 8 |
| Duryee, LM | 1 |
| Garvin, RP | 1 |
| Anderson, DR | 3 |
| Aripova, N | 3 |
| Hunter, CD | 5 |
| Ruskamp, RJ | 3 |
| Tessin, MR | 3 |
| Works, DR | 3 |
| Mikuls, TR | 4 |
| Liang, HW | 1 |
| Yang, TY | 1 |
| Teng, CS | 1 |
| Lee, YJ | 1 |
| Yu, MH | 1 |
| Lee, HJ | 1 |
| Hsu, LS | 1 |
| Wang, CJ | 1 |
| Shuai, C | 1 |
| Xia, GQ | 1 |
| Yuan, F | 1 |
| Wang, S | 2 |
| Lv, XW | 1 |
| Wyatt, TA | 1 |
| Warren, KJ | 1 |
| Wetzel, TJ | 1 |
| Suwondo, T | 1 |
| Rensch, GP | 1 |
| DeVasure, JM | 1 |
| Mosley, DD | 1 |
| Kharbanda, KK | 1 |
| Burnham, EL | 1 |
| Bailey, KL | 1 |
| Yeligar, SM | 1 |
| Kyrklund, M | 1 |
| Kummu, O | 2 |
| Kankaanpää, J | 1 |
| Akhi, R | 1 |
| Nissinen, A | 1 |
| Turunen, SP | 2 |
| Pussinen, P | 1 |
| Wang, C | 2 |
| Hörkkö, S | 2 |
| Wiese, BM | 1 |
| Bowman, JR | 1 |
| Vanlandingham, JD | 1 |
| Klassen, LW | 2 |
| Thiele, GE | 1 |
| He, Q | 1 |
| Diao, Y | 1 |
| Zhao, T | 1 |
| Hou, B | 1 |
| Ngokana, LD | 1 |
| Liang, H | 1 |
| Nie, J | 1 |
| Tan, P | 1 |
| Huang, H | 1 |
| Li, Y | 1 |
| Qi, L | 1 |
| Zhao, Y | 1 |
| Liu, Y | 1 |
| Gao, X | 1 |
| Zhou, L | 1 |
| Ren, J | 3 |
| Ueta, CB | 1 |
| Campos, JC | 1 |
| Albuquerque, RPE | 1 |
| Lima, VM | 1 |
| Disatnik, MH | 1 |
| Sanchez, AB | 1 |
| Chen, CH | 2 |
| de Medeiros, MHG | 1 |
| Yang, W | 1 |
| Mochly-Rosen, D | 2 |
| Ferreira, JCB | 1 |
| Giménez-Gómez, P | 1 |
| Pérez-Hernández, M | 1 |
| Gutiérrez-López, MD | 1 |
| Vidal, R | 1 |
| Abuin-Martínez, C | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
| Domingo-Espín, J | 1 |
| Nilsson, O | 1 |
| Bernfur, K | 1 |
| Del Giudice, R | 1 |
| Lagerstedt, JO | 1 |
| Chen, L | 1 |
| Xiong, X | 1 |
| Hou, X | 1 |
| Wei, H | 1 |
| Zhai, J | 1 |
| Xia, T | 1 |
| Gong, X | 1 |
| Gao, S | 1 |
| Feng, G | 1 |
| Tao, X | 1 |
| Zhang, F | 1 |
| Chen, W | 1 |
| Luo, Z | 1 |
| Liu, H | 1 |
| Sun, X | 1 |
| Guo, R | 1 |
| Cui, R | 1 |
| Ma, X | 1 |
| Yan, M | 1 |
| Albertini, RJ | 1 |
| Prus, P | 1 |
| Lehtimäki, J | 1 |
| Veneskoski, M | 1 |
| Thapaliya, S | 1 |
| Runkana, A | 1 |
| McMullen, MR | 1 |
| Nagy, LE | 1 |
| McDonald, C | 1 |
| Naga Prasad, SV | 1 |
| Dasarathy, S | 1 |
| Oberbeck, N | 1 |
| Langevin, F | 1 |
| King, G | 1 |
| de Wind, N | 1 |
| Crossan, GP | 1 |
| Patel, KJ | 1 |
| Zambelli, VO | 1 |
| Gross, ER | 1 |
| Gutierrez, VP | 1 |
| Cury, Y | 1 |
| Carson, JS | 1 |
| Xiong, W | 1 |
| Dale, M | 1 |
| Yu, F | 1 |
| Baxter, BT | 1 |
| Brandt, M | 1 |
| Garlapati, V | 1 |
| Oelze, M | 1 |
| Sotiriou, E | 1 |
| Knorr, M | 1 |
| Kröller-Schön, S | 1 |
| Kossmann, S | 1 |
| Schönfelder, T | 1 |
| Morawietz, H | 1 |
| Schulz, E | 1 |
| Schultheiss, HP | 1 |
| Daiber, A | 1 |
| Münzel, T | 1 |
| Wenzel, P | 1 |
| Correa, M | 2 |
| Manrique, HM | 1 |
| Font, L | 1 |
| Escrig, MA | 1 |
| Aragon, CM | 2 |
| Lee, JH | 1 |
| Banerjee, A | 1 |
| Ueno, Y | 2 |
| Ramaiah, SK | 1 |
| Rivera-Meza, M | 2 |
| Quintanilla, ME | 2 |
| Tampier, L | 2 |
| Mura, CV | 1 |
| Sapag, A | 1 |
| Israel, Y | 2 |
| Ma, H | 1 |
| Li, J | 1 |
| Gao, F | 1 |
| Karliner, JS | 1 |
| Lee, HS | 1 |
| Song, J | 1 |
| Kim, TM | 1 |
| Joo, SS | 1 |
| Park, D | 1 |
| Jeon, JH | 1 |
| Shin, S | 1 |
| Park, HK | 1 |
| Lee, WK | 1 |
| Ly, SY | 1 |
| Kim, MR | 1 |
| Lee, DI | 1 |
| Kim, YB | 1 |
| Kaphalia, BS | 1 |
| Bhopale, KK | 1 |
| Kondraganti, S | 1 |
| Wu, H | 1 |
| Boor, PJ | 1 |
| Ansari, GA | 1 |
| Willis, MS | 1 |
| Tuma, DJ | 1 |
| Radio, SJ | 1 |
| Schaffert, CS | 1 |
| Karahanian, E | 1 |
| Herrera-Marschitz, M | 1 |
| Kawano, T | 1 |
| Matsuse, H | 1 |
| Fukahori, S | 1 |
| Tsuchida, T | 1 |
| Nishino, T | 1 |
| Fukushima, C | 1 |
| Kohno, S | 1 |
| Roy, HK | 1 |
| Gulizia, JM | 1 |
| Karolski, WJ | 1 |
| Ratashak, A | 1 |
| Sorrell, MF | 1 |
| Tuma, D | 1 |
| Adachi, J | 1 |
| Asano, M | 1 |
| Niemelä, O | 2 |
| Ohlendieck, K | 1 |
| Peters, TJ | 1 |
| Preedy, VR | 2 |
| Quertemont, E | 1 |
| Belluzzi, JD | 1 |
| Wang, R | 1 |
| Leslie, FM | 1 |
| Aleksa, K | 1 |
| Halachmi, N | 1 |
| Ito, S | 1 |
| Koren, G | 1 |
| Arizzi-LaFrance, MN | 1 |
| Salamone, JD | 1 |
| Dahchour, A | 1 |
| Lallemand, F | 1 |
| Ward, RJ | 1 |
| De Witte, P | 1 |
| O'Hanlon, LH | 1 |
| Crabb, DW | 1 |
| Farrés, J | 1 |
| Emery, PW | 1 |
| Yaseen, Z | 1 |
| Michoudet, C | 1 |
| Baverel, G | 1 |
| Dubourg, L | 1 |
| Anderson, RA | 1 |
| Willis, BR | 1 |
| Oswald, C | 1 |
| Zaneveld, LJ | 1 |
| Hjortrup, A | 1 |
| Andersen, BN | 2 |
| Kreutzfeldt, M | 1 |
| Holm, G | 1 |
| Schmidt, A | 1 |
| Poulsen, JS | 1 |
| Green, MA | 1 |
| Egle, JL | 1 |
| Mukherjee, AB | 1 |
| Hodgen, GD | 1 |
| Demol, P | 1 |
| Sarles, H | 1 |
| Boyden, TW | 1 |
| Silvert, MA | 1 |
| Pamenter, RW | 1 |
| Amit, Z | 1 |
| Smith, BR | 1 |
| Brown, ZW | 1 |
| Williams, RL | 1 |
| Honda, S | 1 |
| Fujioka, T | 1 |
| Shiota, K | 1 |
| Fujiyama, K | 1 |
| Kubota, T | 1 |
| Murakami, K | 1 |
| Nasu, M | 1 |
| Nordback, IH | 1 |
| Olson, JL | 1 |
| Chacko, VP | 1 |
| Cameron, JL | 1 |
| Krogulski, A | 1 |
| Zamlauski-Tucker, MJ | 1 |
| Morris, ME | 1 |
| Springate, JE | 1 |
| Bhadra, S | 1 |
| Prather, PL | 1 |
| Elkhayat, I | 1 |
| Benjamin, D | 1 |
| Harris, CM | 1 |
| Lal, H | 1 |
| Halsted, CH | 1 |
| Villanueva, J | 1 |
| Chandler, CJ | 1 |
| Ruebner, B | 1 |
| Munn, RJ | 1 |
| Parkkila, S | 1 |
| Guerri, C | 1 |
| Wu, WJ | 1 |
| Pruett, SB | 1 |
| Iwahashi, K | 1 |
| Itoh, M | 1 |
| Nakamura, K | 1 |
| Ameno, K | 1 |
| Suwaki, H | 1 |
| Takeuchi, Y | 1 |
| Washizuka, M | 1 |
| Hiraga, Y | 1 |
| Furuichi, H | 1 |
| Izumi, J | 1 |
| Yoshinaga, K | 1 |
| Abe, T | 1 |
| Tanaka, Y | 1 |
| Tamaki, H | 1 |
| Liang, Q | 1 |
| Carlson, EC | 1 |
| Borgerding, AJ | 1 |
| Epstein, PN | 1 |
| Matsunaga, T | 1 |
| Hasegawa, C | 1 |
| Kawasuji, T | 1 |
| Suzuki, H | 1 |
| Saito, H | 1 |
| Sagioka, T | 1 |
| Takahashi, R | 1 |
| Tsukamoto, H | 1 |
| Morikawa, T | 1 |
| Akiyama, T | 1 |
| Kasuga, S | 1 |
| Uda, N | 1 |
| Kyo, E | 1 |
| Ushijima, M | 1 |
| Morihara, N | 1 |
| Itakura, Y | 1 |
| Yang, H | 1 |
| Wang, J | 1 |
| Huang, ZZ | 1 |
| Ou, X | 1 |
| Lu, SC | 1 |
| Goldstein, DB | 1 |
| Marr, JJ | 1 |
| Spilberg, I | 1 |
| Hołownia, A | 1 |
| Chwiećko, M | 1 |
| Pawłowska, D | 1 |
| Farbiszewski, R | 1 |
| Skrzydlewska, E | 1 |
| Worowski, K | 1 |
| Roszkowska-Jakimiec, W | 1 |
| Phillips, SC | 1 |
| Lieber, CS | 1 |
| Brien, JF | 1 |
| Clarke, DW | 1 |
| Richardson, B | 1 |
| Patrick, J | 1 |
| Littleton, JM | 1 |
| Griffiths, PJ | 1 |
| Ortiz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oxidative Stress and Surgical Recovery[NCT04732000] | Phase 2 | 21 participants (Actual) | Interventional | 2021-07-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for acetaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy.
Topics: Acetaldehyde; Animals; Autophagy; Cardiomyopathy, Alcoholic; Disease Models, Animal; Ethanol; Heart | 2018 |
Vinyl acetate monomer (VAM) genotoxicity profile: relevance for carcinogenicity.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Carcinogens; Cells, Cultured; Disease Models, Animal; | 2013 |
Alcoholic muscle disease and biomembrane perturbations (review).
Topics: Acetaldehyde; Alcoholism; Animals; Calcium; Cell Membrane; Cholesterol; Disease Models, Animal; Etha | 2003 |
Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism.
Topics: Acetaldehyde; Alcoholism; Aldehyde Dehydrogenase; Animals; Disease Models, Animal; Ethanol; Humans; | 2004 |
Alcoholic myopathy and acetaldehyde.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcohol-Induced Disorders; Animals; Ca | 2007 |
Teratogenic effects of alcohol: current status of animal research and in vitro models.
Topics: Acetaldehyde; Animals; Central Nervous System; Disease Models, Animal; Embryonic and Fetal Developme | 1996 |
Pharmacological aspects of physical dependence on ethanol.
Topics: Acetaldehyde; Adenosine Triphosphatases; Alcoholism; Animals; Behavior, Animal; Disease Models, Anim | 1976 |
[Metabolism of liver proteins in ethanol poisoning].
Topics: Acetaldehyde; Albumins; Alcoholic Intoxication; Animals; Collagen; Disease Models, Animal; Dose-Resp | 1992 |
[Interaction of alcohol with the liver, nutrition, drugs and carcinogens].
Topics: Acetaldehyde; Alcoholism; Animals; Carcinogens; Disease Models, Animal; Ethanol; Humans; Liver; Live | 1985 |
62 other studies available for acetaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Malondialdehyde-Acetaldehyde Modified (MAA) Proteins Differentially Effect the Inflammatory Response in Macrophage, Endothelial Cells and Animal Models of Cardiovascular Disease.
Topics: Acetaldehyde; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Adhesion Molecules; Cells, Cul | 2021 |
A novel reactive aldehyde species inhibitor prevents the deleterious effects of ethanol in an animal model of alcoholic liver disease.
Topics: Acetaldehyde; Aldehydes; Animals; Disease Models, Animal; Ethanol; Liver Diseases, Alcoholic; Malond | 2022 |
A novel reactive aldehyde species inhibitor prevents the deleterious effects of ethanol in an animal model of alcoholic liver disease.
Topics: Acetaldehyde; Aldehydes; Animals; Disease Models, Animal; Ethanol; Liver Diseases, Alcoholic; Malond | 2022 |
A novel reactive aldehyde species inhibitor prevents the deleterious effects of ethanol in an animal model of alcoholic liver disease.
Topics: Acetaldehyde; Aldehydes; Animals; Disease Models, Animal; Ethanol; Liver Diseases, Alcoholic; Malond | 2022 |
A novel reactive aldehyde species inhibitor prevents the deleterious effects of ethanol in an animal model of alcoholic liver disease.
Topics: Acetaldehyde; Aldehydes; Animals; Disease Models, Animal; Ethanol; Liver Diseases, Alcoholic; Malond | 2022 |
Mulberry leaves extract ameliorates alcohol-induced liver damages through reduction of acetaldehyde toxicity and inhibition of apoptosis caused by oxidative stress signals.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Enzy | 2021 |
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Topics: 5'-Nucleotidase; Acetaldehyde; Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Ca | 2021 |
Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol.
Topics: Acetaldehyde; Alcoholism; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Epithelial | 2021 |
Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein.
Topics: Acetaldehyde; Adhesins, Bacterial; Animals; Antibodies, Bacterial; Atherosclerosis; Bacterial Protei | 2018 |
Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation.
Topics: Acetaldehyde; Adoptive Transfer; Animals; Autoimmunity; Cell Movement; Cells, Cultured; Disease Mode | 2018 |
SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice.
Topics: Acetaldehyde; Animals; Apoptosis Regulatory Proteins; Biomarkers; Disease Models, Animal; Fatty Live | 2018 |
Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiotoxicity; Cell Line; Disease Mod | 2018 |
Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Binge Drinking; Brain; Central Nervous System Depressants; | 2018 |
Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism.
Topics: Acetaldehyde; Animals; Apolipoprotein A-I; Blood Glucose; Cardiovascular Diseases; Cell Line; Choles | 2018 |
Wuzhi capsule regulates chloroacetaldehyde pharmacokinetics behaviour and alleviates high-dose cyclophosphamide-induced nephrotoxicity and neurotoxicity in rats.
Topics: Acetaldehyde; Animals; Brain; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship, | 2019 |
RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats.
Topics: Acetaldehyde; Animals; Apoptosis; Cell Line; Cell Proliferation; Collagen Type I; Discoidin Domain R | 2013 |
Human monoclonal Fab and human plasma antibodies to carbamyl-epitopes cross-react with malondialdehyde-adducts.
Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Apoptosis; Atherosclerosis; Autoantibodies; Binding, | 2014 |
Alcohol-induced autophagy contributes to loss in skeletal muscle mass.
Topics: Acetaldehyde; Adult; Aged; Alcohols; Animals; Autophagy; Disease Models, Animal; Female; Humans; Mal | 2014 |
Maternal aldehyde elimination during pregnancy preserves the fetal genome.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc | 2014 |
Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.
Topics: Acetaldehyde; Acute Pain; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Be | 2014 |
Antibodies against malondialdehyde-acetaldehyde adducts can help identify patients with abdominal aortic aneurysm.
Topics: Acetaldehyde; Aged; Aged, 80 and over; Animals; Aortic Aneurysm, Abdominal; Biomarkers; Calcium Chlo | 2016 |
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiomyopathy, Alcoholic; Disease Mod | 2016 |
Reduction in the anxiolytic effects of ethanol by centrally formed acetaldehyde: the role of catalase inhibitors and acetaldehyde-sequestering agents.
Topics: Acetaldehyde; Amitrole; Animals; Anti-Anxiety Agents; Anxiety; Catalase; Central Nervous System Depr | 2008 |
Potential relationship between hepatobiliary osteopontin and peroxisome proliferator-activated receptor alpha expression following ethanol-associated hepatic injury in vivo and in vitro.
Topics: Acetaldehyde; Animals; Bezafibrate; Bile Ducts; Cell Line, Tumor; Disease Models, Animal; Epithelial | 2008 |
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model.
Topics: Acetaldehyde; Adenoviridae; Alcohol Dehydrogenase; Alcoholism; Alleles; Amino Acid Substitution; Ani | 2010 |
Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Blotting, West | 2009 |
Lessons from the besotted heart.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Disease Models | 2009 |
Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Cytoch | 2009 |
Pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice after subchronic exposure to ethanol.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Animals; Cathepsin B; Disease Models, Animal; Endoplasmic Retic | 2010 |
Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites.
Topics: Acetaldehyde; Animals; Biotransformation; Cytosol; Disease Models, Animal; Ethanol; Female; Hepatiti | 2010 |
Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Animals; Catalase; Cues; Disease Models, Animal; Ethanol | 2012 |
Acetaldehyde at a low concentration synergistically exacerbates allergic airway inflammation as an endocrine-disrupting chemical and as a volatile organic compound.
Topics: Acetaldehyde; Administration, Intranasal; Animals; Asthma; Bronchoconstriction; Disease Models, Anim | 2012 |
Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia.
Topics: Abnormalities, Multiple; Acetaldehyde; Animals; Antibody Specificity; Apoptosis; Biomarkers, Tumor; | 2002 |
Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
Topics: Acetaldehyde; Adolescent; Age Factors; Aging; Animals; Brain; Brain Chemistry; Cocaine; Disease Mode | 2005 |
Renal ontogeny of ifosfamide nephrotoxicity.
Topics: Acetaldehyde; Age Factors; Animals; Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases | 2004 |
Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde.
Topics: Acetaldehyde; Alcohol-Induced Disorders, Nervous System; Animals; Catalase; Central Nervous System D | 2006 |
Production of reactive oxygen species following acute ethanol or acetaldehyde and its reduction by acamprosate in chronically alcoholized rats.
Topics: Acamprosate; Acetaldehyde; Alcohol Deterrents; Alcoholism; Animals; Disease Models, Animal; Ethanol; | 2005 |
Studies seek molecular clues on alcohol's role in cancer.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Oxidoreductases; Animals; Cell Cultu | 2005 |
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; | 2007 |
In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro.
Topics: Acetaldehyde; Acetyl Coenzyme A; Adenosine Triphosphate; Amifostine; Animals; Disease Models, Animal | 2008 |
Male reproductive tract sensitivity to ethanol: a critical overview.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Disease Models, Animal; Ethanol; Fertility; Genitalia, Male | 1983 |
Effect of intra-arterial administration of acetaldehyde on pig pancreas.
Topics: Acetaldehyde; Animals; Disease Models, Animal; Infusions, Intra-Arterial; Pancreas; Pancreatitis; Sw | 1983 |
The effects of acetaldehyde and acrolein on blood pressure in guanethidine-pretreated hypertensive rats.
Topics: Acetaldehyde; Acrolein; Aldehydes; Animals; Blood Pressure; Disease Models, Animal; Drug Interaction | 1983 |
Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys.
Topics: Acetaldehyde; Animals; Disease Models, Animal; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Fe | 1982 |
Chronic ethanol consumption and exocrine pancreatic response to ethanol and acetaldehyde in the rat.
Topics: Acetaldehyde; Alcoholism; Animals; Disease Models, Animal; Ethanol; Humans; Pancreas; Rats | 1980 |
Acetaldehyde acutely impairs canine testicular testosterone secretion.
Topics: Acetaldehyde; Alcoholism; Animals; Chorionic Gonadotropin; Disease Models, Animal; Dogs; Ethanol; Hu | 1981 |
An examination of the role of TIQ alkaloids in alcohol intake: reinforcers, satiety agents or artifacts.
Topics: Acetaldehyde; Alcoholism; Alkaloids; Animals; Body Weight; Disease Models, Animal; Ethanol; Humans; | 1982 |
Effects of ethanol on the pancreas of disulfiram-treated rats.
Topics: Acetaldehyde; Acute Disease; Administration, Oral; Amylases; Animals; Disease Models, Animal; Disulf | 1995 |
Detailed characterization of experimental acute alcoholic pancreatitis.
Topics: Acetaldehyde; Acute Disease; Alcoholism; Animals; Disease Models, Animal; Dogs; Free Radicals; Ische | 1995 |
[Usefulness of the fruit fly for assessment of mutagenicity of benzene, acetaldehyde and formaldehyde].
Topics: Acetaldehyde; Animals; Benzene; Disease Models, Animal; Drosophila melanogaster; Environmental Pollu | 1994 |
Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney.
Topics: Absorption; Acetaldehyde; Acrolein; Animals; Chemotherapy, Cancer, Regional Perfusion; Disease Model | 1994 |
Anxiogenic effect of disulfiram evaluated in an animal model.
Topics: Acetaldehyde; Animals; Appetitive Behavior; Arousal; Conditioning, Operant; Discrimination Learning; | 1993 |
Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig.
Topics: Acetaldehyde; Animals; Collagen; Disease Models, Animal; Ethanol; Iron; Liver; Liver Diseases, Alcoh | 1993 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity.
Topics: Acetaldehyde; Acetates; Alcoholism; Animals; Cells, Cultured; Disease Models, Animal; Ethanol; Femal | 1996 |
[Acetaldehyde adducts in the cerebral cortex of ethanol-fed mice].
Topics: Acetaldehyde; Alcoholism; Animals; Brain; Disease Models, Animal; Immunohistochemistry; Male; Mice; | 1997 |
[Effect of liver hydrolysate on ethanol- and acetaldehyde-induced deficiencies].
Topics: Acetaldehyde; Alanine Transaminase; Alcoholic Intoxication; Animals; Aspartate Aminotransferases; Ca | 1998 |
A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy.
Topics: Acetaldehyde; Actins; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiomyopathy, Alcoholic; D | 1999 |
Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica.
Topics: Acetaldehyde; Animals; Anti-Ulcer Agents; Aspirin; Cycadopsida; Disease Models, Animal; Gastric Juic | 2000 |
Pharmacologic activities of aged garlic extract in comparison with other garlic preparations.
Topics: Acetaldehyde; Animals; Antineoplastic Agents; Cell Division; Dehydration; Disease Models, Animal; Fo | 2001 |
Cloning and characterization of the 5'-flanking region of the rat glutamate-cysteine ligase catalytic subunit.
Topics: 5' Untranslated Regions; Acetaldehyde; Animals; Base Sequence; Catalysis; Cell Line; Cloning, Molecu | 2001 |
A mechanism for decreased resistance to infection by gram-negative organisms during acute alcoholic intoxication.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Bacteria; Bacterial Infections; Blood Bac | 1975 |
The diminution of liver glutathione content and changes in activities of antioxidant enzymes in long-term acetaldehyde poisoning.
Topics: Acetaldehyde; Animals; Antioxidants; Catalase; Disease Models, Animal; Glutathione; Glutathione Pero | 1992 |
Can brain lesions occur in experimental animals by administration of ethanol or acetaldehyde?
Topics: Acetaldehyde; Administration, Inhalation; Alcoholism; Animals; Brain; Disease Models, Animal; Disulf | 1987 |
Disposition of ethanol in maternal blood, fetal blood, and amniotic fluid of third-trimester pregnant ewes.
Topics: Acetaldehyde; Amniotic Fluid; Animals; Blood; Disease Models, Animal; Ethanol; Female; Fetal Blood; | 1985 |
The induction of ethanol dependence and the ethanol withdrawal syndrome: the effects of pyrazole.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholism; Animals; Body Weight; Brain Chemistry; Disease Mo | 1974 |