acetaldehyde has been researched along with Carcinoma, Epidermoid in 26 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with inactive acetaldehyde dehydrogenase 2 (ALDH2) are at high risk for esophageal squamous cell carcinoma (ESCC) and hypopharyngeal squamous cell carcinoma (HPSCC)." | 5.41 | Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma. ( Arima, S; Fujita, H; Hashimoto, S; Ido, A; Iwaya, H; Kabayama, M; Kanmura, S; Komaki, Y; Maeda, H; Oda, K; Sasaki, F; Tanoue, S, 2021) |
| "Esophageal squamous cell carcinoma (ESCC) accounts for the large majority of esophageal cancer cases worldwide." | 2.82 | Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma. ( Abrams, JA; Etemadi, A; Soroush, A, 2022) |
| " On the basis of this review, we believe that there is now sufficient evidence to accept the proposition that alcohol-containing mouthwashes contribute to the increased risk of development of oral cancer and further feel that it is inadvisable for oral healthcare professionals to recommend the long-term use of alcohol-containing mouthwashes." | 2.44 | The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes. ( Farah, CS; McCullough, MJ, 2008) |
| "Worldwide, oral cancer represents approximately 5 per cent of all malignant lesions, with over 800 new intra-oral squamous cell carcinomas registered in Australia each year." | 2.44 | The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes. ( Farah, CS; McCullough, MJ, 2008) |
| "Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon." | 1.72 | Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. ( Abe, H; Asano, N; Asanuma, K; Hamada, S; Hatta, W; Imatani, A; Jin, X; Kanno, T; Koike, T; Masamune, A; Nakamura, T; Nakaya, N; Ogata, Y; Ono, Y; Saito, M; Toda, S; Uno, K, 2022) |
| "Using RNA-sequencing data from 136 HNSCC patients, we compared the expression levels of 1,046 microRNAs between drinking and non-drinking cohorts." | 1.42 | Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma. ( Kim, E; Korrapati, A; Kuo, SZ; Ongkeko, WM; Rahimy, E; Rahimy, M; Saad, MA; Wang-Rodriguez, J; Yu, MA; Zheng, H; Zou, AE, 2015) |
| "Upon inhibition of these miRNAs, HNSCC cell lines exhibited increased sensitivity to cisplatin and reduced matrigel invasion." | 1.42 | Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma. ( Kim, E; Korrapati, A; Kuo, SZ; Ongkeko, WM; Rahimy, E; Rahimy, M; Saad, MA; Wang-Rodriguez, J; Yu, MA; Zheng, H; Zou, AE, 2015) |
| "Acetaldehyde is a carcinogenic product of alcohol fermentation and metabolism in microbes associated with cancers of the upper digestive tract." | 1.39 | Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans. ( Bowyer, P; Kaihovaara, P; Marttila, E; Rautemaa, R; Richardson, M; Salaspuro, M; Sanglard, D; Uittamo, J, 2013) |
| "A total of 90 patients [30 oral squamous cell carcinoma (OSCC); 30 oral lichenoid disease (OLD); 30 healthy controls (CO)] were enrolled in the study." | 1.39 | Acetaldehyde production and microbial colonization in oral squamous cell carcinoma and oral lichenoid disease. ( Lindqvist, C; Marttila, E; Rautemaa, R; Rusanen, P; Salaspuro, M; Uittamo, J, 2013) |
| "Alcohol is a risk factor for oral squamous cell carcinoma." | 1.39 | Alcohol and oral squamous cell carcinoma. ( Chandran, R; Feller, L; Khammissa, RA; Lemmer, J; Meyerov, R, 2013) |
| "Esophageal cancer is unusually frequent in Western Kenya, despite the low prevalence of classical risk factors such as heavy drinking and tobacco smoking." | 1.39 | Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya. ( Abnet, CC; Bowyer, P; Collins, R; Dawsey, SM; Dawsey, SP; Freedman, ND; Mwachiro, M; Nieminen, MT; Novak-Frazer, L; Rautemaa, R; Salaspuro, M; White, RE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 12 (46.15) | 24.3611 |
| 2020's | 4 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Toda, S | 1 |
| Hatta, W | 1 |
| Asanuma, K | 1 |
| Asano, N | 1 |
| Ono, Y | 1 |
| Abe, H | 1 |
| Ogata, Y | 1 |
| Saito, M | 1 |
| Kanno, T | 1 |
| Jin, X | 1 |
| Uno, K | 1 |
| Koike, T | 1 |
| Imatani, A | 1 |
| Hamada, S | 1 |
| Nakamura, T | 1 |
| Nakaya, N | 1 |
| Masamune, A | 1 |
| Marttila, E | 4 |
| Rusanen, P | 3 |
| Uittamo, J | 4 |
| Salaspuro, M | 6 |
| Rautemaa-Richardson, R | 1 |
| Salo, T | 1 |
| Sasaki, F | 1 |
| Kanmura, S | 1 |
| Oda, K | 1 |
| Maeda, H | 1 |
| Kabayama, M | 1 |
| Iwaya, H | 1 |
| Komaki, Y | 1 |
| Arima, S | 1 |
| Tanoue, S | 1 |
| Hashimoto, S | 1 |
| Fujita, H | 1 |
| Ido, A | 1 |
| Soroush, A | 1 |
| Etemadi, A | 1 |
| Abrams, JA | 1 |
| Matejcic, M | 1 |
| Gunter, MJ | 1 |
| Ferrari, P | 1 |
| Mizumoto, A | 1 |
| Ohashi, S | 1 |
| Hirohashi, K | 1 |
| Amanuma, Y | 1 |
| Matsuda, T | 1 |
| Muto, M | 1 |
| Bowyer, P | 2 |
| Sanglard, D | 1 |
| Kaihovaara, P | 1 |
| Richardson, M | 1 |
| Rautemaa, R | 4 |
| Lindqvist, C | 2 |
| Feller, L | 1 |
| Chandran, R | 1 |
| Khammissa, RA | 1 |
| Meyerov, R | 1 |
| Lemmer, J | 1 |
| Szabó, A | 1 |
| Tarnai, Z | 1 |
| Berkovits, C | 1 |
| Novák, P | 1 |
| Mohácsi, Á | 1 |
| Braunitzer, G | 1 |
| Rakonczay, Z | 1 |
| Turzó, K | 1 |
| Nagy, K | 1 |
| Szabó, G | 1 |
| Grover, J | 1 |
| Sen, S | 1 |
| Carnelio, S | 1 |
| Saad, MA | 1 |
| Kuo, SZ | 1 |
| Rahimy, E | 1 |
| Zou, AE | 1 |
| Korrapati, A | 1 |
| Rahimy, M | 1 |
| Kim, E | 1 |
| Zheng, H | 1 |
| Yu, MA | 1 |
| Wang-Rodriguez, J | 1 |
| Ongkeko, WM | 1 |
| McCullough, MJ | 1 |
| Farah, CS | 1 |
| Brooks, PJ | 1 |
| Enoch, MA | 1 |
| Goldman, D | 1 |
| Li, TK | 1 |
| Yokoyama, A | 3 |
| Lee, CH | 1 |
| Wu, DC | 1 |
| Wu, IC | 1 |
| Goan, YG | 1 |
| Lee, JM | 1 |
| Chou, SH | 1 |
| Chan, TF | 1 |
| Huang, HL | 1 |
| Hung, YH | 1 |
| Huang, MC | 1 |
| Lai, TC | 1 |
| Wang, TN | 1 |
| Lan, CC | 1 |
| Tsai, S | 1 |
| Lin, WY | 1 |
| Wu, MT | 1 |
| Omori, T | 1 |
| Yokoyama, T | 1 |
| Yamaguchi, H | 1 |
| Hosoya, M | 1 |
| Shimoyama, T | 1 |
| Takahashi, S | 1 |
| Zhang, JF | 1 |
| Tsutsumi, E | 1 |
| Suzuki, Y | 1 |
| Suwa, Y | 1 |
| Nakayama, T | 1 |
| Nieminen, MT | 1 |
| Novak-Frazer, L | 1 |
| Collins, R | 1 |
| Dawsey, SP | 1 |
| Dawsey, SM | 1 |
| Abnet, CC | 1 |
| White, RE | 1 |
| Freedman, ND | 1 |
| Mwachiro, M | 1 |
| Paget, V | 1 |
| Lechevrel, M | 1 |
| Sichel, F | 1 |
| Warnakulasuriya, S | 1 |
| Parkkila, S | 1 |
| Nagao, T | 1 |
| Preedy, VR | 1 |
| Pasanen, M | 1 |
| Koivisto, H | 1 |
| Niemelä, O | 1 |
| Woutersen, RA | 2 |
| Appelman, LM | 2 |
| Feron, VJ | 2 |
| Van der Heijden, CA | 1 |
| Toth, B | 1 |
| Patil, K | 1 |
| Muramatsu, T | 1 |
| Ohmori, T | 1 |
| Higuchi, S | 1 |
| Hayashida, M | 1 |
| Ishii, H | 1 |
| Jokelainen, K | 1 |
| Heikkonen, E | 1 |
| Roine, R | 1 |
| Lehtonen, H | 1 |
| Van Garderen-Hoetmer, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement[NCT05261620] | 132 participants (Anticipated) | Interventional | 2022-12-12 | Recruiting | |||
| The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study[NCT02884817] | Phase 4 | 59 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Treatment of Asian Flushing Syndrome With Topical Alpha Agonists[NCT03497442] | Early Phase 1 | 20 participants (Actual) | Interventional | 2018-07-12 | Completed | ||
| The THINKER Study: A Pilot for a Case-Control of Esophageal Squamous Cell Carcinoma in Western Kenya[NCT00901173] | 372 participants (Actual) | Observational | 2014-02-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for acetaldehyde and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Esophageal Squamous Cell Carc | 2022 |
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Biomarkers, Tumor; Carcinoma, Squamous Cell; | 2017 |
Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.
Topics: Acetaldehyde; Animals; Carcinogenesis; Carcinoma, Squamous Cell; DNA Damage; Esophageal Neoplasms; E | 2017 |
The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Biotransformation; Carcinoma, Squamous Cell; Ethanol; Human | 2008 |
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, M | 2009 |
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Al | 2010 |
1 trial available for acetaldehyde and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breath Tests; Carcinoma, Squamous C | 2021 |
19 other studies available for acetaldehyde and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; Carcinoma, Squamous Cell; Claud | 2022 |
Expression of p53 is associated with microbial acetaldehyde production in oralsquamous cell carcinoma.
Topics: Acetaldehyde; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Mouth Neoplasms; Tumor Supp | 2021 |
Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans.
Topics: Acetaldehyde; Acetate-CoA Ligase; Acetyl Coenzyme A; Alcohol Dehydrogenase; Aldehyde Oxidoreductases | 2013 |
Acetaldehyde production and microbial colonization in oral squamous cell carcinoma and oral lichenoid disease.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analysis of Variance; Carcinoma, Squ | 2013 |
Alcohol and oral squamous cell carcinoma.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Carcinoma, Squamous Cell; DNA Damage; Ethanol | 2013 |
Volatile sulphur compound measurement with OralChroma(TM): a methodological improvement.
Topics: Acetaldehyde; Adult; Breath Tests; Butadienes; Calibration; Carcinoma, Squamous Cell; Case-Control S | 2015 |
Site-specific acetaldehyde production and microbial colonization in relation to oral squamous cell carcinoma and oral lichenoid disease.
Topics: Acetaldehyde; Alcohol Drinking; Carcinoma, Squamous Cell; Female; Humans; Lichen Planus, Oral; Male; | 2015 |
Site-specific acetaldehyde production and microbial colonization in relation to oral squamous cell carcinoma and oral lichenoid disease.
Topics: Acetaldehyde; Alcohol Drinking; Carcinoma, Squamous Cell; Female; Humans; Lichen Planus, Oral; Male; | 2015 |
Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma.
Topics: Acetaldehyde; Adult; Alcohols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Prolifera | 2015 |
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehy | 2009 |
Catalytic removal of acetaldehyde in saliva by a Gluconobacter strain.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Beverages; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, | 2012 |
Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya.
Topics: Acetaldehyde; Animals; Candida; Carcinoma, Squamous Cell; Colony Count, Microbial; Developing Countr | 2013 |
Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast).
Topics: Acetaldehyde; Alcohol Drinking; Alleles; Carcinoma, Squamous Cell; Cells, Cultured; DNA Mutational A | 2008 |
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer.
Topics: Acetaldehyde; Alcoholism; Aldehydes; Carcinoma, Squamous Cell; Cytochrome P-450 CYP2E1; Ethanol; Fem | 2008 |
Inhalation toxicity of acetaldehyde in rats. II. Carcinogenicity study: interim results after 15 months.
Topics: Acetaldehyde; Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relation | 1984 |
Gyromitrin as a tumor inducer.
Topics: Acetaldehyde; Adenocarcinoma; Adenoma; Animals; Basidiomycota; Carcinogens; Carcinoma, Squamous Cell | 1981 |
Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; | 1996 |
Increased acetaldehyde production by mouthwashings from patients with oral cavity, laryngeal, or pharyngeal cancer.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Carcinoma, Squamous Cell; Ethanol; F | 1996 |
Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study.
Topics: Acetaldehyde; Adenocarcinoma; Administration, Inhalation; Animals; Body Weight; Carcinoma, Squamous | 1986 |