acetaldehyde has been researched along with Carcinogenesis in 17 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alcohol consumption is the key risk factor for the development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major carcinogen that causes DNA damage." | 3.96 | Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice. ( Amanuma, Y; Baba, K; Hirohashi, K; Ida, T; Kikuchi, O; Matsubara, J; Matsuda, T; Mitani, Y; Miyamoto, S; Mizumoto, A; Muto, M; Nakai, Y; Ohashi, S; Seno, H; Yamada, A; Yamamoto, Y, 2020) |
| "Approximately 4% of cancers worldwide are caused by alcohol consumption." | 2.72 | Alcohol and Cancer: Epidemiology and Biological Mechanisms. ( Ferrari, P; Murphy, N; Rumgay, H; Soerjomataram, I, 2021) |
| "Acetaldehyde has been classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen to humans." | 2.55 | Molecular Basis of Alcohol-Related Gastric and Colon Cancer. ( Lee, JY; Na, HK, 2017) |
| "Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon." | 1.72 | Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. ( Abe, H; Asano, N; Asanuma, K; Hamada, S; Hatta, W; Imatani, A; Jin, X; Kanno, T; Koike, T; Masamune, A; Nakamura, T; Nakaya, N; Ogata, Y; Ono, Y; Saito, M; Toda, S; Uno, K, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Rumgay, H | 1 |
| Murphy, N | 1 |
| Ferrari, P | 1 |
| Soerjomataram, I | 1 |
| Matsuzaki, K | 1 |
| Kumatoriya, K | 1 |
| Tando, M | 1 |
| Kometani, T | 1 |
| Shinohara, M | 1 |
| Toda, S | 1 |
| Hatta, W | 1 |
| Asanuma, K | 1 |
| Asano, N | 1 |
| Ono, Y | 1 |
| Abe, H | 1 |
| Ogata, Y | 1 |
| Saito, M | 1 |
| Kanno, T | 1 |
| Jin, X | 1 |
| Uno, K | 1 |
| Koike, T | 1 |
| Imatani, A | 1 |
| Hamada, S | 1 |
| Nakamura, T | 1 |
| Nakaya, N | 1 |
| Masamune, A | 1 |
| Moreira, MTG | 3 |
| Pereira, PR | 3 |
| Aquino, A | 3 |
| Conte-Junior, CA | 3 |
| Paschoalin, VMF | 3 |
| Song, BJ | 1 |
| Abdelmegeed, MA | 1 |
| Cho, YE | 1 |
| Akbar, M | 1 |
| Rhim, JS | 1 |
| Song, MK | 1 |
| Hardwick, JP | 1 |
| Koyanagi, YN | 1 |
| Suzuki, E | 1 |
| Imoto, I | 1 |
| Kasugai, Y | 1 |
| Oze, I | 1 |
| Ugai, T | 1 |
| Iwase, M | 1 |
| Usui, Y | 1 |
| Kawakatsu, Y | 1 |
| Sawabe, M | 1 |
| Hirayama, Y | 1 |
| Tanaka, T | 1 |
| Abe, T | 1 |
| Ito, S | 1 |
| Komori, K | 1 |
| Hanai, N | 1 |
| Tajika, M | 1 |
| Shimizu, Y | 1 |
| Niwa, Y | 1 |
| Ito, H | 1 |
| Matsuo, K | 1 |
| Silva, P | 1 |
| Latruffe, N | 1 |
| Gaetano, G | 1 |
| Zhang, XN | 1 |
| Meng, FG | 1 |
| Wang, YR | 1 |
| Liu, SX | 1 |
| Zeng, T | 1 |
| Na, HK | 1 |
| Lee, JY | 1 |
| Mizumoto, A | 2 |
| Ohashi, S | 2 |
| Hirohashi, K | 2 |
| Amanuma, Y | 2 |
| Matsuda, T | 2 |
| Muto, M | 2 |
| Salaspuro, M | 2 |
| Nakai, Y | 1 |
| Ida, T | 1 |
| Baba, K | 1 |
| Mitani, Y | 1 |
| Yamamoto, Y | 1 |
| Kikuchi, O | 1 |
| Matsubara, J | 1 |
| Yamada, A | 1 |
| Miyamoto, S | 1 |
| Seno, H | 1 |
| Yang, M | 1 |
| Zhang, Y | 1 |
| Ren, J | 1 |
| Brooks, PJ | 1 |
| Zakhari, S | 1 |
| Hellström, PM | 1 |
| Hendolin, P | 1 |
| Kaihovaara, P | 1 |
| Kronberg, L | 1 |
| Meierjohann, A | 1 |
| Millerhovf, A | 1 |
| Paloheimo, L | 1 |
| Sundelin, H | 1 |
| Syrjänen, K | 1 |
| Webb, DL | 1 |
| Gelfand, R | 1 |
| Vernet, D | 1 |
| Bruhn, KW | 1 |
| Sarkissyan, S | 1 |
| Heber, D | 1 |
| Vadgama, JV | 1 |
| Gonzalez-Cadavid, NF | 1 |
| Müller, MF | 1 |
| Zhou, Y | 1 |
| Adams, DJ | 1 |
| Arends, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement[NCT05261620] | 132 participants (Anticipated) | Interventional | 2022-12-12 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for acetaldehyde and Carcinogenesis
| Article | Year |
|---|---|
Alcohol and Cancer: Epidemiology and Biological Mechanisms.
Topics: Acetaldehyde; Alcohol Drinking; Alcohol-Induced Disorders; Carcinogenesis; DNA Damage; DNA Methylati | 2021 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks.
Topics: Acetaldehyde; Aged; Aldehydes; Beer; Carcinogenesis; Carcinogens; Humans | 2022 |
Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis.
Topics: Acetaldehyde; Alcohol-Related Disorders; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytochrome P-450 E | 2019 |
Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Anti-Inflammatory Agents; Antioxidants; Carcinogenesis; DNA | 2020 |
Molecular Basis of Alcohol-Related Gastric and Colon Cancer.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Animals; Carcinogenes | 2017 |
Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.
Topics: Acetaldehyde; Animals; Carcinogenesis; Carcinoma, Squamous Cell; DNA Damage; Esophageal Neoplasms; E | 2017 |
Key role of local acetaldehyde in upper GI tract carcinogenesis.
Topics: Acetaldehyde; Carcinogenesis; Ethanol; Gastrointestinal Neoplasms; Humans | 2017 |
ALDH2 Polymorphism and Ethanol Consumption: A Genetic-Environmental Interaction in Carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; Gene-Environm | 2019 |
Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; DNA R | 2014 |
1 trial available for acetaldehyde and Carcinogenesis
| Article | Year |
|---|---|
Slow-release L-cysteine capsule prevents gastric mucosa exposure to carcinogenic acetaldehyde: results of a randomised single-blinded, cross-over study of Helicobacter-associated atrophic gastritis.
Topics: Acetaldehyde; Adult; Carbolines; Carcinogenesis; Cross-Over Studies; Cysteine; Delayed-Action Prepar | 2017 |
7 other studies available for acetaldehyde and Carcinogenesis
| Article | Year |
|---|---|
Polyphenols from persimmon fruit attenuate acetaldehyde-induced DNA double-strand breaks by scavenging acetaldehyde.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; Diospyros; DNA Adducts; DNA Bre | 2022 |
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; Carcinoma, Squamous Cell; Claud | 2022 |
Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis.
Topics: Acetaldehyde; Adult; Aged; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; | 2020 |
Transformed ALDH2
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinogenesis | 2021 |
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Animals; Benzamides; Benzodio | 2020 |
Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features.
Topics: Acetaldehyde; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Epithelial-Mesenchymal Transitio | 2017 |
Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc | 2017 |