acetaldehyde has been researched along with Cancer of Mouth in 27 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral cancer is the sixth most common cancer worldwide and a major health problem in some parts of the world." | 2.46 | Oral cancer and polymorphism of ethanol metabolising genes. ( Acha-Sagredo, A; Aguirre-Urizar, JM; Marichalar-Mendia, X; Rey-Barja, N; Rodriguez-Tojo, MJ, 2010) |
| " On the basis of this review, we believe that there is now sufficient evidence to accept the proposition that alcohol-containing mouthwashes contribute to the increased risk of development of oral cancer and further feel that it is inadvisable for oral healthcare professionals to recommend the long-term use of alcohol-containing mouthwashes." | 2.44 | The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes. ( Farah, CS; McCullough, MJ, 2008) |
| "Worldwide, oral cancer represents approximately 5 per cent of all malignant lesions, with over 800 new intra-oral squamous cell carcinomas registered in Australia each year." | 2.44 | The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes. ( Farah, CS; McCullough, MJ, 2008) |
| "Candida isolated from patients with oral cancer demonstrated significantly higher biofilm mass (P = 0." | 1.43 | Candida virulence and ethanol-derived acetaldehyde production in oral cancer and non-cancer subjects. ( Alnuaimi, AD; Kolev, SD; McCullough, MJ; O'Brien-Simpson, NM; Ramdzan, AN; Reynolds, EC; Wiesenfeld, D, 2016) |
| "Acetaldehyde is a carcinogenic product of alcohol fermentation and metabolism in microbes associated with cancers of the upper digestive tract." | 1.39 | Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans. ( Bowyer, P; Kaihovaara, P; Marttila, E; Rautemaa, R; Richardson, M; Salaspuro, M; Sanglard, D; Uittamo, J, 2013) |
| "A total of 90 patients [30 oral squamous cell carcinoma (OSCC); 30 oral lichenoid disease (OLD); 30 healthy controls (CO)] were enrolled in the study." | 1.39 | Acetaldehyde production and microbial colonization in oral squamous cell carcinoma and oral lichenoid disease. ( Lindqvist, C; Marttila, E; Rautemaa, R; Rusanen, P; Salaspuro, M; Uittamo, J, 2013) |
| "Alcohol is a risk factor for oral squamous cell carcinoma." | 1.39 | Alcohol and oral squamous cell carcinoma. ( Chandran, R; Feller, L; Khammissa, RA; Lemmer, J; Meyerov, R, 2013) |
| "An increased risk of oral cancer has been discussed for users of such mouthwashes; however, epidemiological evidence had remained inconclusive." | 1.35 | Salivary acetaldehyde increase due to alcohol-containing mouthwash use: a risk factor for oral cancer. ( Gumbel-Mako, S; Keck-Wilhelm, A; Kratz, E; Lachenmeier, DW; Mildau, G; Sohnius, EM, 2009) |
| "Acetaldehyde was analyzed from salivary samples gas chromatographically at 0, 5, and 10 minutes from the beginning of the smoking." | 1.33 | Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking. ( Hietala, JM; Marvola, ML; Salaspuro, MP; Salaspuro, VJ, 2006) |
| "Acetaldehyde has been shown to dissolve into the saliva during smoking and to be a local carcinogen in the human upper digestive tract." | 1.33 | Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking. ( Hietala, JM; Marvola, ML; Salaspuro, MP; Salaspuro, VJ, 2006) |
| "As acetaldehyde seems to be a carcinogenic factor associated with chronic alcohol consumption, alcoholics with the alcohol dehydrogenase (ADH) 1C*1 allele seem to be particularly at risk as this allele encodes for a rapidly ethanol metabolising enzyme leading to increased acetaldehyde levels." | 1.32 | Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. ( Benesova, M; Conradt, C; Götte, K; Homann, N; Hörrmann, K; Inoue, H; Li, J; Salaspuro, M; Seitz, HK; Tisch, M; Väkeväinen, S; Visapää, JP, 2004) |
| "Oral cancer and alcoholic cirrhosis are relatively common diseases encountered in medical and dental practices." | 1.31 | Chronic alcoholism: a common risk factor in oral cancer and alcoholic cirrhosis. ( Perkins, I; Perkins, TM, 2001) |
| "A major risk factor common to both oral cancer and alcoholic cirrhosis is the excessive use of alcohol." | 1.31 | Chronic alcoholism: a common risk factor in oral cancer and alcoholic cirrhosis. ( Perkins, I; Perkins, TM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Smędra, A | 1 |
| Berent, J | 1 |
| Silva, P | 1 |
| Latruffe, N | 1 |
| Gaetano, G | 1 |
| Marttila, E | 4 |
| Rusanen, P | 3 |
| Uittamo, J | 6 |
| Salaspuro, M | 11 |
| Rautemaa-Richardson, R | 1 |
| Salo, T | 1 |
| Bowyer, P | 1 |
| Sanglard, D | 1 |
| Kaihovaara, P | 3 |
| Richardson, M | 1 |
| Rautemaa, R | 5 |
| Lindqvist, C | 4 |
| Feller, L | 1 |
| Chandran, R | 1 |
| Khammissa, RA | 1 |
| Meyerov, R | 1 |
| Lemmer, J | 1 |
| Tao, L | 1 |
| Pavlova, SI | 1 |
| Gasparovich, SR | 1 |
| Jin, L | 1 |
| Schwartz, J | 1 |
| Szabó, A | 1 |
| Tarnai, Z | 1 |
| Berkovits, C | 1 |
| Novák, P | 1 |
| Mohácsi, Á | 1 |
| Braunitzer, G | 1 |
| Rakonczay, Z | 1 |
| Turzó, K | 1 |
| Nagy, K | 1 |
| Szabó, G | 1 |
| Grover, J | 1 |
| Sen, S | 1 |
| Carnelio, S | 1 |
| Alnuaimi, AD | 1 |
| Ramdzan, AN | 1 |
| Wiesenfeld, D | 1 |
| O'Brien-Simpson, NM | 1 |
| Kolev, SD | 1 |
| Reynolds, EC | 1 |
| McCullough, MJ | 2 |
| Meurman, JH | 3 |
| Siikala, E | 1 |
| Farah, CS | 1 |
| Iacopino, AM | 1 |
| Lachenmeier, DW | 1 |
| Gumbel-Mako, S | 1 |
| Sohnius, EM | 1 |
| Keck-Wilhelm, A | 1 |
| Kratz, E | 1 |
| Mildau, G | 1 |
| Marichalar-Mendia, X | 1 |
| Rodriguez-Tojo, MJ | 1 |
| Acha-Sagredo, A | 1 |
| Rey-Barja, N | 1 |
| Aguirre-Urizar, JM | 2 |
| Gainza-Cirauqui, ML | 1 |
| Nieminen, MT | 1 |
| Novak Frazer, L | 1 |
| Moragues, MD | 1 |
| Visapää, JP | 1 |
| Götte, K | 1 |
| Benesova, M | 1 |
| Li, J | 1 |
| Homann, N | 4 |
| Conradt, C | 1 |
| Inoue, H | 1 |
| Tisch, M | 1 |
| Hörrmann, K | 1 |
| Väkeväinen, S | 1 |
| Seitz, HK | 1 |
| Salaspuro, VJ | 1 |
| Hietala, JM | 1 |
| Marvola, ML | 1 |
| Salaspuro, MP | 1 |
| Kartal, A | 1 |
| Hietala, J | 1 |
| Laakso, I | 1 |
| Salaspuro, V | 1 |
| Säkkinen, M | 1 |
| Marvola, M | 1 |
| Warnakulasuriya, S | 1 |
| Parkkila, S | 1 |
| Nagao, T | 1 |
| Preedy, VR | 1 |
| Pasanen, M | 1 |
| Koivisto, H | 1 |
| Niemelä, O | 1 |
| Jokelainen, K | 1 |
| Heikkonen, E | 1 |
| Roine, R | 1 |
| Lehtonen, H | 1 |
| Tillonen, J | 3 |
| Rautio, M | 2 |
| Jousimies-Somer, H | 2 |
| Rintamäki, H | 2 |
| Perkins, TM | 1 |
| Perkins, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw[NCT03418454] | 150 participants (Anticipated) | Observational | 2017-12-14 | Recruiting | |||
| The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study[NCT02884817] | Phase 4 | 59 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetaldehyde and Cancer of Mouth
| Article | Year |
|---|---|
The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Dysbiosis; Ethanol; Humans; Microbiota; | 2023 |
Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Anti-Inflammatory Agents; Antioxidants; Carcinogenesis; DNA | 2020 |
Oral micro-organisms in the etiology of cancer.
Topics: Acetaldehyde; Alcohol Drinking; Bacteria; Carcinogens; Humans; Mouth; Mouth Neoplasms; Oral Health; | 2008 |
The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Biotransformation; Carcinoma, Squamous Cell; Ethanol; Human | 2008 |
Oral cancer and polymorphism of ethanol metabolising genes.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Cytochrome P-450 CYP2E1; Ethanol; Fem | 2010 |
22 other studies available for acetaldehyde and Cancer of Mouth
| Article | Year |
|---|---|
Expression of p53 is associated with microbial acetaldehyde production in oralsquamous cell carcinoma.
Topics: Acetaldehyde; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Mouth Neoplasms; Tumor Supp | 2021 |
Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans.
Topics: Acetaldehyde; Acetate-CoA Ligase; Acetyl Coenzyme A; Alcohol Dehydrogenase; Aldehyde Oxidoreductases | 2013 |
Acetaldehyde production and microbial colonization in oral squamous cell carcinoma and oral lichenoid disease.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analysis of Variance; Carcinoma, Squ | 2013 |
Alcohol and oral squamous cell carcinoma.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Carcinoma, Squamous Cell; DNA Damage; Ethanol | 2013 |
Alcohol metabolism by oral streptococci and interaction with human papillomavirus leads to malignant transformation of oral keratinocytes.
Topics: Acetaldehyde; Bacterial Adhesion; Cell Transformation, Neoplastic; Ethanol; Human papillomavirus 16; | 2015 |
Volatile sulphur compound measurement with OralChroma(TM): a methodological improvement.
Topics: Acetaldehyde; Adult; Breath Tests; Butadienes; Calibration; Carcinoma, Squamous Cell; Case-Control S | 2015 |
Site-specific acetaldehyde production and microbial colonization in relation to oral squamous cell carcinoma and oral lichenoid disease.
Topics: Acetaldehyde; Alcohol Drinking; Carcinoma, Squamous Cell; Female; Humans; Lichen Planus, Oral; Male; | 2015 |
Site-specific acetaldehyde production and microbial colonization in relation to oral squamous cell carcinoma and oral lichenoid disease.
Topics: Acetaldehyde; Alcohol Drinking; Carcinoma, Squamous Cell; Female; Humans; Lichen Planus, Oral; Male; | 2015 |
Candida virulence and ethanol-derived acetaldehyde production in oral cancer and non-cancer subjects.
Topics: Acetaldehyde; Biofilms; Candida; Candidiasis, Oral; Case-Control Studies; Ethanol; Female; Humans; M | 2016 |
Chronic candidosis and oral cancer in APECED-patients: production of carcinogenic acetaldehyde from glucose and ethanol by Candida albicans.
Topics: Acetaldehyde; Adult; Age of Onset; Candida albicans; Candidiasis, Oral; Carcinogens; Chronic Disease | 2009 |
Surveillance spotlight: use of alcohol-containing rinses to reduce oral microbial burden: safety and efficacy.
Topics: Acetaldehyde; Alcoholic Beverages; Biofilms; Cell Membrane Permeability; Ethanol; Humans; Mouth Neop | 2009 |
Salivary acetaldehyde increase due to alcohol-containing mouthwash use: a risk factor for oral cancer.
Topics: Acetaldehyde; Adult; Anti-Infective Agents, Local; Chromatography, Gas; Ethanol; European Union; Fem | 2009 |
Production of carcinogenic acetaldehyde by Candida albicans from patients with potentially malignant oral mucosal disorders.
Topics: Acetaldehyde; Adaptation, Physiological; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Candida a | 2013 |
Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholism; Ethanol; Female; Gene Frequency; Genotype; Humans; | 2004 |
Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking.
Topics: Acetaldehyde; Adult; Cysteine; Dose-Response Relationship, Drug; Female; Gastrointestinal Neoplasms; | 2006 |
Formulation and in-vivo evaluation of L-cysteine chewing gums for binding carcinogenic acetaldehyde in the saliva during smoking.
Topics: Acetaldehyde; Adult; Carcinogens; Chewing Gum; Cysteine; Female; Humans; Laryngeal Neoplasms; Male; | 2007 |
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer.
Topics: Acetaldehyde; Alcoholism; Aldehydes; Carcinoma, Squamous Cell; Cytochrome P-450 CYP2E1; Ethanol; Fem | 2008 |
Increased acetaldehyde production by mouthwashings from patients with oral cavity, laryngeal, or pharyngeal cancer.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Carcinoma, Squamous Cell; Ethanol; F | 1996 |
Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer.
Topics: Acetaldehyde; Alcohol Drinking; Candida albicans; Ethanol; Humans; Mouth Neoplasms; Saliva; Smoking | 1999 |
Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer.
Topics: Acetaldehyde; Adult; Aged; Bacteria; Colony Count, Microbial; Ethanol; Female; Fungi; Humans; Male; | 2000 |
Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Bacteria, Aerobic; Bacteria, Anaerob | 2001 |
Chronic alcoholism: a common risk factor in oral cancer and alcoholic cirrhosis.
Topics: Acetaldehyde; Adult; Alcoholism; Black People; Carcinogens; Ethanol; Female; Hepatocytes; Humans; Li | 2001 |