acetaldehyde has been researched along with Cancer of Liver in 29 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alcohol dehydrogenase and acetaldehyde dehydrogenases have been associated with hepatocellular carcinoma, but how alcohol dehydrogenase and acetaldehyde dehydrogenases alter the prognosis of hepatocellular carcinoma have not been completely elucidated." | 8.12 | Effects of Gene Polymorphisms, Metabolic Activity, and Content of Alcohol Dehydrogenase and Acetaldehyde Dehydrogenases on Prognosis of Hepatocellular Carcinoma Patients. ( Chen, J; Fang, Y; Gao, N; Guo, Y; Han, Z; Qi, B; Qiao, HL; Zhao, T, 2022) |
| "Metabolic activities, gene polymorphisms, and content of alcohol dehydrogenase and acetaldehyde dehydrogenases were determined in 68 fibrotic livers from hepatocellular carcinoma patients." | 8.12 | Effects of Gene Polymorphisms, Metabolic Activity, and Content of Alcohol Dehydrogenase and Acetaldehyde Dehydrogenases on Prognosis of Hepatocellular Carcinoma Patients. ( Chen, J; Fang, Y; Gao, N; Guo, Y; Han, Z; Qi, B; Qiao, HL; Zhao, T, 2022) |
| "Acetaldehyde is an important substance for tumor regression." | 5.35 | Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells. ( Hung, CM; Kao, ST; Lee, KH; Liu, CJ; Yeh, CC; Yeh, MH, 2009) |
| "Alcohol dehydrogenase and acetaldehyde dehydrogenases have been associated with hepatocellular carcinoma, but how alcohol dehydrogenase and acetaldehyde dehydrogenases alter the prognosis of hepatocellular carcinoma have not been completely elucidated." | 4.12 | Effects of Gene Polymorphisms, Metabolic Activity, and Content of Alcohol Dehydrogenase and Acetaldehyde Dehydrogenases on Prognosis of Hepatocellular Carcinoma Patients. ( Chen, J; Fang, Y; Gao, N; Guo, Y; Han, Z; Qi, B; Qiao, HL; Zhao, T, 2022) |
| "Metabolic activities, gene polymorphisms, and content of alcohol dehydrogenase and acetaldehyde dehydrogenases were determined in 68 fibrotic livers from hepatocellular carcinoma patients." | 4.12 | Effects of Gene Polymorphisms, Metabolic Activity, and Content of Alcohol Dehydrogenase and Acetaldehyde Dehydrogenases on Prognosis of Hepatocellular Carcinoma Patients. ( Chen, J; Fang, Y; Gao, N; Guo, Y; Han, Z; Qi, B; Qiao, HL; Zhao, T, 2022) |
| "Acetaldehyde is an important substance for tumor regression." | 1.35 | Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells. ( Hung, CM; Kao, ST; Lee, KH; Liu, CJ; Yeh, CC; Yeh, MH, 2009) |
| "The acetaldehyde level was usually markedly low." | 1.32 | Pharmacokinetic study of ethanol and its metabolites in culture cells. ( Aki, T; Fujimiya, T; Ohbora, Y; Shinagawa, H, 2003) |
| "Acetaldehyde was oxidized by rat and human hepatic microsomes in the presence of NADPH." | 1.30 | Acetaldehyde as well as ethanol is metabolized by human CYP2E1. ( Funae, Y; Hiroi, T; Imaoka, S; Kunitoh, S; Monna, T; Yabusaki, Y, 1997) |
| "Using the human hepatocellular carcinoma cell line, Hep G2, we have constructed an hepatic cell line that stably expresses alcohol dehydrogenase." | 1.29 | Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase. ( Clemens, DL; Halgard, CM; Miles, RR; Sorrell, MF; Tuma, DJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 2 |
| Myojin, T | 1 |
| Li, K | 1 |
| Kurita, A | 2 |
| Seto, M | 1 |
| Motoyama, A | 1 |
| Liu, X | 1 |
| Satoh, A | 1 |
| Munemasa, S | 2 |
| Murata, Y | 2 |
| Nakamura, T | 2 |
| Nakamura, Y | 2 |
| Gao, N | 1 |
| Chen, J | 2 |
| Qi, B | 1 |
| Zhao, T | 1 |
| Guo, Y | 1 |
| Fang, Y | 1 |
| Han, Z | 1 |
| Qiao, HL | 1 |
| Xia, P | 1 |
| Liu, DH | 1 |
| Wang, D | 1 |
| Wen, GM | 1 |
| Zhao, ZY | 1 |
| Wang, WJ | 1 |
| Gao, YH | 1 |
| Zhang, XN | 1 |
| Meng, FG | 1 |
| Wang, YR | 1 |
| Liu, SX | 1 |
| Zeng, T | 1 |
| Sanchez, AC | 1 |
| Li, C | 1 |
| Andrews, B | 1 |
| Asenjo, JA | 1 |
| Samulski, RJ | 1 |
| Nakashima, S | 1 |
| Zhu, B | 1 |
| Zakhari, S | 1 |
| Zheng, ZP | 1 |
| Yan, Y | 1 |
| Xia, J | 1 |
| Zhang, S | 1 |
| Wang, M | 1 |
| Xu, Y | 1 |
| Yeh, MH | 1 |
| Kao, ST | 1 |
| Hung, CM | 1 |
| Liu, CJ | 1 |
| Lee, KH | 1 |
| Yeh, CC | 1 |
| McKillop, IH | 1 |
| Schrum, LW | 1 |
| Fujimiya, T | 1 |
| Shinagawa, H | 1 |
| Ohbora, Y | 1 |
| Aki, T | 1 |
| Gómez-Quiroz, LE | 1 |
| Paris, R | 1 |
| Lluis, JM | 1 |
| Bucio, L | 2 |
| Souza, V | 2 |
| Hernández, E | 2 |
| Gutiérrez, M | 1 |
| Santiago, M | 1 |
| García-Ruiz, C | 1 |
| Fernández-Checa, JC | 1 |
| Kershenobich, D | 2 |
| Gutiérrez-Ruiz, MC | 2 |
| Kannarkat, GT | 1 |
| Tuma, DJ | 3 |
| Tuma, PL | 1 |
| Li, CX | 1 |
| Zhang, Y | 1 |
| Gao, L | 1 |
| Hsiang, CY | 1 |
| Wu, SL | 1 |
| Chen, JC | 1 |
| Lo, HY | 1 |
| Li, CC | 1 |
| Chiang, SY | 1 |
| Wu, HC | 1 |
| Ho, TY | 1 |
| Loew, GH | 1 |
| Rebagliati, M | 1 |
| Poulsen, M | 1 |
| Jenkins, W | 1 |
| Ganne-Carrié, N | 1 |
| Kremsdorf, D | 1 |
| Garreau, F | 1 |
| Thévenin, M | 1 |
| Petit, MA | 1 |
| Nalpas, B | 1 |
| Bréchot, C | 1 |
| Clemens, DL | 2 |
| Halgard, CM | 1 |
| Miles, RR | 1 |
| Sorrell, MF | 2 |
| Kunitoh, S | 1 |
| Imaoka, S | 1 |
| Hiroi, T | 1 |
| Yabusaki, Y | 1 |
| Monna, T | 1 |
| Funae, Y | 1 |
| Tudek, B | 1 |
| Kowalczyk, P | 1 |
| Cieśla, JM | 1 |
| Gomez Quiroz, LE | 1 |
| Llorente, L | 1 |
| Forman, A | 1 |
| Jerrells, TR | 1 |
| Stickel, F | 1 |
| Schuppan, D | 1 |
| Hahn, EG | 1 |
| Seitz, HK | 1 |
| Cederbaum, AI | 1 |
| Rubin, E | 1 |
| Wickramasinghe, SN | 1 |
| Hasan, R | 1 |
| Ferro, M | 1 |
| Muzio, G | 1 |
| Bassi, AM | 1 |
| Biocca, ME | 1 |
| Canuto, RA | 1 |
| Worrall, S | 1 |
| De Jersey, J | 1 |
| Shanley, BC | 1 |
| Wilce, PA | 1 |
4 reviews available for acetaldehyde and Cancer of Liver
| Article | Year |
|---|---|
Chronic alcohol drinking: Liver and pancreatic cancer?
Topics: Acetaldehyde; Adaptive Immunity; Alcoholism; Carcinoma, Hepatocellular; Central Nervous System Depre | 2015 |
Role of alcohol in liver carcinogenesis.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2009 |
Liver disorders in alcoholism.
Topics: Acetaldehyde; Animals; Carcinoma, Hepatocellular; Ethanol; Fatty Liver, Alcoholic; Hepatitis, Alcoho | 1984 |
Cocarcinogenic effects of alcohol in hepatocarcinogenesis.
Topics: Acetaldehyde; Animals; Carcinogens; Carcinoma, Hepatocellular; Cocarcinogenesis; Cytokines; Diet; En | 2002 |
25 other studies available for acetaldehyde and Cancer of Liver
| Article | Year |
|---|---|
A Major Intestinal Catabolite of Quercetin Glycosides, 3-Hydroxyphenylacetic Acid, Protects the Hepatocytes from the Acetaldehyde-Induced Cytotoxicity through the Enhancement of the Total Aldehyde Dehydrogenase Activity.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; Cytoprote | 2022 |
Effects of Gene Polymorphisms, Metabolic Activity, and Content of Alcohol Dehydrogenase and Acetaldehyde Dehydrogenases on Prognosis of Hepatocellular Carcinoma Patients.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; | 2022 |
SLC3A2, as an indirect target gene of ALDH2, exacerbates alcohol-associated liver cancer via the sphingolipid biosynthesis pathway.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinoma, Hep | 2023 |
[Aldehyde dehydrogenase with hepatocellular carcinoma].
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Carcinoma, Hepatocellular; Ethanol; Humans; Liver Neoplasms | 2020 |
Transformed ALDH2
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carcinogenesis | 2021 |
AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochondrial; Asian People; Car | 2017 |
3,4-Dihydroxyphenylacetic acid is a potential aldehyde dehydrogenase inducer in murine hepatoma Hepa1c1c7 cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetaldehyde; Aldehyde Dehydrogenase; Animals; Carcinoma, Hepatocell | 2017 |
A phenylacetaldehyde-flavonoid adduct, 8-C-(E-phenylethenyl)-norartocarpetin, exhibits intrinsic apoptosis and MAPK pathways-related anticancer potential on HepG2, SMMC-7721 and QGY-7703.
Topics: Acetaldehyde; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Flavonoids; Food Handling; Hep G2 | 2016 |
Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells.
Topics: Acetaldehyde; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell M | 2009 |
Pharmacokinetic study of ethanol and its metabolites in culture cells.
Topics: Acetaldehyde; Acetates; Animals; Carcinoma, Hepatocellular; Central Nervous System Depressants; Chro | 2003 |
Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde.
Topics: Acetaldehyde; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Combinations; Hepatocytes; | 2005 |
Microtubules are more stable and more highly acetylated in ethanol-treated hepatic cells.
Topics: Acetaldehyde; Acetylation; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Central Nervous Sys | 2006 |
[Analysis of combinated transcatheter hepatic artery chemoembolization and factors affecting the prognosis in patients with primary hepatic carcinoma].
Topics: Acetaldehyde; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, H | 2006 |
Acetaldehyde induces matrix metalloproteinase-9 gene expression via nuclear factor-kappaB and activator protein 1 signaling pathways in human hepatocellular carcinoma cells: Association with the invasive potential.
Topics: Acetaldehyde; Binding Sites; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nu | 2007 |
Metabolism and relative carcinogenic potency of chloroethanes: a quantum chemical structure-activity study.
Topics: Acetaldehyde; Animals; Biotransformation; Carcinogens; Carcinoma, Hepatocellular; Chemical Phenomena | 1984 |
Effects of ethanol on hepatitis B virus Pre-S/S gene expression in the human hepatocellular carcinoma derived HEP G2 hepatitis B DNA positive cell line.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Animals; Blotting, Northern; Carcinoma, Hepatocellular; DNA, Vi | 1995 |
Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Animals; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; | 1995 |
Acetaldehyde as well as ethanol is metabolized by human CYP2E1.
Topics: Acetaldehyde; Adult; Animals; Carcinoma, Hepatocellular; Cloning, Molecular; Cytochrome P-450 CYP2E1 | 1997 |
Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis.
Topics: Acetaldehyde; Adenine; Animals; Cytosine; DNA Damage; DNA Fingerprinting; DNA Repair; Exons; Genes, | 1999 |
Cytokine response and oxidative stress produced by ethanol, acetaldehyde and endotoxin treatment in HepG2 cells.
Topics: Acetaldehyde; Analysis of Variance; Base Sequence; Carcinoma, Hepatocellular; Cytokines; Endotoxins; | 2001 |
Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Carcinoma, Hepatocellular; Cell Division; Cell Survival; Centra | 2002 |
The oxidation of acetaldehyde by isolated mitochondria from various organs of the rat and hepatocellular carcinoma.
Topics: Acetaldehyde; Adenosine Diphosphate; Animals; Antimycin A; Atractyloside; Carcinoma; Citrates; Dinit | 1977 |
Comparison of the generation of albumin-associated cytotoxic activity in supernatants from ethanol-containing cultures of human blood monocyte-derived macrophages and of two human hepatoma cell lines.
Topics: Acetaldehyde; Alcohol Drinking; Carcinoma, Hepatocellular; Cell Line; Cytotoxicity, Immunologic; Eth | 1991 |
Comparative subcellular distribution of benzaldehyde and acetaldehyde dehydrogenase activities in two hepatoma cell lines and in normal hepatocytes.
Topics: Acetaldehyde; Aldehyde Oxidoreductases; Aldehydes; Animals; Benzaldehydes; Carcinoma, Hepatocellular | 1991 |
Antibodies against acetaldehyde-modified epitopes: presence in alcoholic, non-alcoholic liver disease and control subjects.
Topics: Acetaldehyde; Alcohol Drinking; Autoantibodies; Blood Proteins; Carcinoma, Hepatocellular; Enzyme-Li | 1990 |