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acetaldehyde and Breast Cancer

acetaldehyde has been researched along with Breast Cancer in 24 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Research Excerpts

ExcerptRelevanceReference
" Despite the association between ethanol consumption and breast cancer risk, and the increasing evidence for an involvement of PPARs in some cancers, there have been no studies on the effect of ethanol or its metabolite acetaldehyde on PPARs in breast cancer."7.74PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008)
" Ethanol (20 mM) reduced the potency of the PPARbeta ligand GW0742, evident by a rightward shift in the GW0742 dose-response curve, whereas for PPARalpha activation by GW7647, ethanol mediated its effects primarily through reducing efficacy as evidenced by a reduction in maximal response."5.35PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008)
"Using the MCF-7 breast cancer cell line, we examined the relationship between ethanol and its metabolite acetaldehyde on PPARalpha and PPARbeta transactivation."5.35PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008)
"MCF7 human breast cancer cells were incubated with different GA concentrations and O2*- production, lipid peroxidation, and carbonylated protein were assessed."5.33Glycolaldehyde induces growth inhibition and oxidative stress in human breast cancer cells. ( Al-Enezi, KS; Alkhalaf, M; Benov, LT, 2006)
" To demonstrate the performance of the platform in physiologic assays, we continuously recorded the kinetics of metabolic and morphologic parameters of MCF-7 breast cancer cells under the influence of the cytotoxin chloroacetaldehyde."3.79Automated platform for sensor-based monitoring and controlled assays of living cells and tissues. ( Brischwein, M; Demmel, F; Kleinhans, R; Pfister, C; Schwarzenberger, T; Wolf, B; Wolf, P, 2013)
" Despite the association between ethanol consumption and breast cancer risk, and the increasing evidence for an involvement of PPARs in some cancers, there have been no studies on the effect of ethanol or its metabolite acetaldehyde on PPARs in breast cancer."3.74PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008)
"Formaldehyde, acetaldehyde and acetone expired from tumor-bearing transgenic mice and formaldehyde exhaled from breast cancer patients were analyzed using gas chromatography."3.69Quantitative analysis by gas chromatography of volatile carbonyl compounds in expired air from mice and human. ( Clifford, AJ; Ebeler, SE; Shibamoto, T, 1997)
"Several questions regarding alcohol and breast cancer need to be addressed."2.52Links between alcohol consumption and breast cancer: a look at the evidence. ( Colditz, GA; Liu, Y; Nguyen, N, 2015)
"Acetaldehyde itself is a cancer-causing substance in experimental animals and reacts with DNA to form cancer-promoting compounds."2.44Alcohol metabolism and cancer risk. ( Becker, P; Seitz, HK, 2007)
"Primary breast cancer cells also responded to chloroacetaldehyde with a marked reduction in deltapO2, followed by a reduced rate of acidification."2.42Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells. ( Brischwein, M; Grothe, H; Motrescu, E; Otto, AM; Wolf, B, 2003)
"Alcoholism is associated with breast cancer incidence and progression, and moderate chronic consumption of ethanol is a risk factor."1.43Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features. ( Bruhn, K; Gelfand, R; Gonzalez-Cadavid, NF; Vadgama, J; Vernet, D, 2016)
"Taken together with somatic breast cancer genome data, these results point to a breakdown in a BRCA/FA-mSWI/SNF-ΔNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells that may contribute to sporadic breast cancer development."1.43BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. ( Bierie, B; Dimitrov, SD; Feunteun, J; Gelman, R; Giobbie-Hurder, A; Li, AG; Liu, B; Livingston, DM; Pathania, S; Polyak, K; Toomire, K; Wang, H, 2016)
" Ethanol (20 mM) reduced the potency of the PPARbeta ligand GW0742, evident by a rightward shift in the GW0742 dose-response curve, whereas for PPARalpha activation by GW7647, ethanol mediated its effects primarily through reducing efficacy as evidenced by a reduction in maximal response."1.35PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008)
"Using the MCF-7 breast cancer cell line, we examined the relationship between ethanol and its metabolite acetaldehyde on PPARalpha and PPARbeta transactivation."1.35PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008)
"MCF7 human breast cancer cells were incubated with different GA concentrations and O2*- production, lipid peroxidation, and carbonylated protein were assessed."1.33Glycolaldehyde induces growth inhibition and oxidative stress in human breast cancer cells. ( Al-Enezi, KS; Alkhalaf, M; Benov, LT, 2006)
"Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis."1.32Glycolaldehyde induces apoptosis in a human breast cancer cell line. ( Al-Maghrebi, MA; Al-Mulla, F; Benov, LT, 2003)
"About 4% of the breast cancers in developed countries are estimated to be attributable to drinking alcohol."1.32Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. ( Castro, GD; Castro, JA; Maciel, ME, 2004)
"Through 1999, 1,875 cases of breast cancer were identified through linkage to the Iowa Surveillance, Epidemiology, and End Results registry."1.31Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women. ( Cerhan, JR; Folsom, AR; Gapstur, SM; Kushi, LH; Olson, JE; Pankratz, VS; Sellers, TA; Vachon, CM; Vierkant, RA, 2002)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.17)18.2507
2000's12 (50.00)29.6817
2010's9 (37.50)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Molina, JC1
Guerrero-Morán, JD1
González-Espinosa, C1
Sadok, I1
Rachwał, K1
Staniszewska, M1
Testino, G1
Caputo, F1
Patussi, V1
Scafato, E1
Nagykálnai, T1
Landherr, L1
Wolf, P1
Brischwein, M3
Kleinhans, R1
Demmel, F1
Schwarzenberger, T1
Pfister, C1
Wolf, B3
Liu, Y1
Nguyen, N1
Colditz, GA1
Gelfand, R2
Vernet, D2
Bruhn, K1
Vadgama, J1
Gonzalez-Cadavid, NF2
Wang, H1
Bierie, B1
Li, AG1
Pathania, S1
Toomire, K1
Dimitrov, SD1
Liu, B1
Gelman, R1
Giobbie-Hurder, A1
Feunteun, J1
Polyak, K1
Livingston, DM1
Bruhn, KW1
Sarkissyan, S1
Heber, D1
Vadgama, JV1
Knouzy, B1
Dubourg, L1
Baverel, G1
Michoudet, C1
Fanelli, SL2
Maciel, ME3
Díaz Gómez, MI1
Delgado de Layño, AM2
Bietto, FM1
Castro, JA4
Castro, GD4
Sellers, TA1
Vierkant, RA1
Cerhan, JR1
Gapstur, SM1
Vachon, CM1
Olson, JE1
Pankratz, VS1
Kushi, LH1
Folsom, AR1
Otto, AM1
Grothe, H1
Motrescu, E1
Al-Maghrebi, MA1
Al-Mulla, F1
Benov, LT2
Singletary, KW1
Barnes, SL1
van Breemen, RB1
de Castro, CR1
de Ferreyra, EC1
Gómez, MI1
Al-Enezi, KS1
Alkhalaf, M1
Seitz, HK1
Becker, P1
Venkata, NG1
Aung, CS1
Cabot, PJ1
Monteith, GR1
Roberts-Thomson, SJ1
Ebeler, SE1
Clifford, AJ1
Shibamoto, T1
Börner, K1
Kisro, J1
Brüggemann, SK1
Hagenah, W1
Peters, SO1
Wagner, T1
Costantini, MH1
Henning, T1
Baumann, W1
Ehret, R1
Freund, I1
Kammerer, R1
Lehmann, M1
Schwinde, A1

Reviews

4 reviews available for acetaldehyde and Breast Cancer

ArticleYear
[Alcohol and breast cancer. A short survey].
    Magyar onkologia, 2018, Mar-23, Volume: 62, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Breast Neoplasms; Carcinogens; DNA Damage; Et

2018
Links between alcohol consumption and breast cancer: a look at the evidence.
    Women's health (London, England), 2015, Volume: 11, Issue:1

    Topics: Acetaldehyde; Adenocarcinoma; Alcohol Drinking; Breast Neoplasms; Estrogens; Ethanol; Female; Humans

2015
Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2003, Volume: 161

    Topics: Acetaldehyde; Antibiotics, Antineoplastic; Biosensing Techniques; Breast Neoplasms; Drug Resistance,

2003
Alcohol metabolism and cancer risk.
    Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2007, Volume: 30, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Induced Disorders; Aldehyde Dehydrogenase; Alleles; Bre

2007

Other Studies

20 other studies available for acetaldehyde and Breast Cancer

ArticleYear
Alcohol: Immunomodulatory Effects and Cancer.
    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 2023, Volume: 75, Issue:3

    Topics: Acetaldehyde; Alcohol Drinking; Breast Neoplasms; Ethanol; Female; Humans; Inflammation

2023
Application of the optimized and validated LC-MS method for simultaneous quantification of tryptophan metabolites in culture medium from cancer cells.
    Journal of pharmaceutical and biomedical analysis, 2019, Nov-30, Volume: 176

    Topics: Acetaldehyde; Breast Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Culture Medi

2019
Alcohol and cancer: no threshold exists.
    Minerva medica, 2020, Volume: 111, Issue:6

    Topics: Acetaldehyde; Alcohol Abstinence; Alcohol Drinking; Alcoholic Beverages; Breast Neoplasms; Confidenc

2020
Automated platform for sensor-based monitoring and controlled assays of living cells and tissues.
    Biosensors & bioelectronics, 2013, Dec-15, Volume: 50

    Topics: Acetaldehyde; Biosensing Techniques; Breast; Breast Neoplasms; Cell Line, Tumor; Cytotoxins; Electri

2013
Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features.
    International journal of oncology, 2016, Volume: 48, Issue:6

    Topics: Acetaldehyde; Breast; Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Epithelial Cell

2016
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.
    Molecular cell, 2016, 07-21, Volume: 63, Issue:2

    Topics: Acetaldehyde; BRCA1 Protein; Breast Neoplasms; Cell Differentiation; Cell Line; Cell Transformation,

2016
Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features.
    International journal of oncology, 2017, Volume: 50, Issue:1

    Topics: Acetaldehyde; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Epithelial-Mesenchymal Transitio

2017
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7.
    Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:3

    Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brea

2010
Further studies on the potential contribution of acetaldehyde accumulation and oxidative stress in rat mammary tissue in the alcohol drinking promotion of breast cancer.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:1

    Topics: Acetaldehyde; Alcohol Drinking; Animals; Breast Neoplasms; Ethanol; Female; Free Radicals; Oxidative

2011
Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Volume: 11, Issue:10 Pt 1

    Topics: Acetaldehyde; Aged; Alcohol Drinking; Breast Neoplasms; Cohort Studies; Female; Folic Acid; Folic Ac

2002
Glycolaldehyde induces apoptosis in a human breast cancer cell line.
    Archives of biochemistry and biophysics, 2003, Sep-01, Volume: 417, Issue:1

    Topics: Acetaldehyde; Apoptosis; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Dose-Response Re

2003
Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells.
    Cancer letters, 2004, Jan-20, Volume: 203, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaldehyde; Benzo(a)pyrene; Breast Neoplasms; Cell Line, Tumor; Deoxy

2004
Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid.
    Nutrition and cancer, 2004, Volume: 49, Issue:1

    Topics: Acetaldehyde; Alcohol Drinking; Animals; Biotransformation; Breast; Breast Neoplasms; Cytosol; Ethan

2004
Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: potential factors involved in alcohol drinking promotion of breast cancer.
    Toxicology, 2006, Feb-15, Volume: 219, Issue:1-3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaldehyde; Alcohol Drinking; Animals; Breast Neoplasms; Central Nerv

2006
Glycolaldehyde induces growth inhibition and oxidative stress in human breast cancer cells.
    Free radical biology & medicine, 2006, Apr-01, Volume: 40, Issue:7

    Topics: Acetaldehyde; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; Lipid Pe

2006
PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 102, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Breast Neoplasms; Cell Line, Tumor; C

2008
Quantitative analysis by gas chromatography of volatile carbonyl compounds in expired air from mice and human.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Nov-21, Volume: 702, Issue:1-2

    Topics: Acetaldehyde; Acetone; Adult; Aged; Animals; Breast Neoplasms; Breath Tests; Carcinoma; Chromatograp

1997
Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:5

    Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Humans; Ifosfamide; Mice

2000
Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.
    Toxicology, 2001, Mar-07, Volume: 160, Issue:1-3

    Topics: Acetaldehyde; Alcohol Drinking; Animals; Animals, Outbred Strains; Biotransformation; Breast; Breast

2001
Approach to a multiparametric sensor-chip-based tumor chemosensitivity assay.
    Anti-cancer drugs, 2001, Volume: 12, Issue:1

    Topics: Acetaldehyde; Antibiotics, Antineoplastic; Biosensing Techniques; Breast Neoplasms; Doxorubicin; Dru

2001