acetaldehyde has been researched along with Breast Cancer in 24 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Excerpt | Relevance | Reference |
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" Despite the association between ethanol consumption and breast cancer risk, and the increasing evidence for an involvement of PPARs in some cancers, there have been no studies on the effect of ethanol or its metabolite acetaldehyde on PPARs in breast cancer." | 7.74 | PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008) |
" Ethanol (20 mM) reduced the potency of the PPARbeta ligand GW0742, evident by a rightward shift in the GW0742 dose-response curve, whereas for PPARalpha activation by GW7647, ethanol mediated its effects primarily through reducing efficacy as evidenced by a reduction in maximal response." | 5.35 | PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008) |
"Using the MCF-7 breast cancer cell line, we examined the relationship between ethanol and its metabolite acetaldehyde on PPARalpha and PPARbeta transactivation." | 5.35 | PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008) |
"MCF7 human breast cancer cells were incubated with different GA concentrations and O2*- production, lipid peroxidation, and carbonylated protein were assessed." | 5.33 | Glycolaldehyde induces growth inhibition and oxidative stress in human breast cancer cells. ( Al-Enezi, KS; Alkhalaf, M; Benov, LT, 2006) |
" To demonstrate the performance of the platform in physiologic assays, we continuously recorded the kinetics of metabolic and morphologic parameters of MCF-7 breast cancer cells under the influence of the cytotoxin chloroacetaldehyde." | 3.79 | Automated platform for sensor-based monitoring and controlled assays of living cells and tissues. ( Brischwein, M; Demmel, F; Kleinhans, R; Pfister, C; Schwarzenberger, T; Wolf, B; Wolf, P, 2013) |
" Despite the association between ethanol consumption and breast cancer risk, and the increasing evidence for an involvement of PPARs in some cancers, there have been no studies on the effect of ethanol or its metabolite acetaldehyde on PPARs in breast cancer." | 3.74 | PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008) |
"Formaldehyde, acetaldehyde and acetone expired from tumor-bearing transgenic mice and formaldehyde exhaled from breast cancer patients were analyzed using gas chromatography." | 3.69 | Quantitative analysis by gas chromatography of volatile carbonyl compounds in expired air from mice and human. ( Clifford, AJ; Ebeler, SE; Shibamoto, T, 1997) |
"Several questions regarding alcohol and breast cancer need to be addressed." | 2.52 | Links between alcohol consumption and breast cancer: a look at the evidence. ( Colditz, GA; Liu, Y; Nguyen, N, 2015) |
"Acetaldehyde itself is a cancer-causing substance in experimental animals and reacts with DNA to form cancer-promoting compounds." | 2.44 | Alcohol metabolism and cancer risk. ( Becker, P; Seitz, HK, 2007) |
"Primary breast cancer cells also responded to chloroacetaldehyde with a marked reduction in deltapO2, followed by a reduced rate of acidification." | 2.42 | Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells. ( Brischwein, M; Grothe, H; Motrescu, E; Otto, AM; Wolf, B, 2003) |
"Alcoholism is associated with breast cancer incidence and progression, and moderate chronic consumption of ethanol is a risk factor." | 1.43 | Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features. ( Bruhn, K; Gelfand, R; Gonzalez-Cadavid, NF; Vadgama, J; Vernet, D, 2016) |
"Taken together with somatic breast cancer genome data, these results point to a breakdown in a BRCA/FA-mSWI/SNF-ΔNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells that may contribute to sporadic breast cancer development." | 1.43 | BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. ( Bierie, B; Dimitrov, SD; Feunteun, J; Gelman, R; Giobbie-Hurder, A; Li, AG; Liu, B; Livingston, DM; Pathania, S; Polyak, K; Toomire, K; Wang, H, 2016) |
" Ethanol (20 mM) reduced the potency of the PPARbeta ligand GW0742, evident by a rightward shift in the GW0742 dose-response curve, whereas for PPARalpha activation by GW7647, ethanol mediated its effects primarily through reducing efficacy as evidenced by a reduction in maximal response." | 1.35 | PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008) |
"Using the MCF-7 breast cancer cell line, we examined the relationship between ethanol and its metabolite acetaldehyde on PPARalpha and PPARbeta transactivation." | 1.35 | PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. ( Aung, CS; Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Venkata, NG, 2008) |
"MCF7 human breast cancer cells were incubated with different GA concentrations and O2*- production, lipid peroxidation, and carbonylated protein were assessed." | 1.33 | Glycolaldehyde induces growth inhibition and oxidative stress in human breast cancer cells. ( Al-Enezi, KS; Alkhalaf, M; Benov, LT, 2006) |
"Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis." | 1.32 | Glycolaldehyde induces apoptosis in a human breast cancer cell line. ( Al-Maghrebi, MA; Al-Mulla, F; Benov, LT, 2003) |
"About 4% of the breast cancers in developed countries are estimated to be attributable to drinking alcohol." | 1.32 | Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. ( Castro, GD; Castro, JA; Maciel, ME, 2004) |
"Through 1999, 1,875 cases of breast cancer were identified through linkage to the Iowa Surveillance, Epidemiology, and End Results registry." | 1.31 | Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women. ( Cerhan, JR; Folsom, AR; Gapstur, SM; Kushi, LH; Olson, JE; Pankratz, VS; Sellers, TA; Vachon, CM; Vierkant, RA, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (4.17) | 18.2507 |
2000's | 12 (50.00) | 29.6817 |
2010's | 9 (37.50) | 24.3611 |
2020's | 2 (8.33) | 2.80 |
Authors | Studies |
---|---|
Molina, JC | 1 |
Guerrero-Morán, JD | 1 |
González-Espinosa, C | 1 |
Sadok, I | 1 |
Rachwał, K | 1 |
Staniszewska, M | 1 |
Testino, G | 1 |
Caputo, F | 1 |
Patussi, V | 1 |
Scafato, E | 1 |
Nagykálnai, T | 1 |
Landherr, L | 1 |
Wolf, P | 1 |
Brischwein, M | 3 |
Kleinhans, R | 1 |
Demmel, F | 1 |
Schwarzenberger, T | 1 |
Pfister, C | 1 |
Wolf, B | 3 |
Liu, Y | 1 |
Nguyen, N | 1 |
Colditz, GA | 1 |
Gelfand, R | 2 |
Vernet, D | 2 |
Bruhn, K | 1 |
Vadgama, J | 1 |
Gonzalez-Cadavid, NF | 2 |
Wang, H | 1 |
Bierie, B | 1 |
Li, AG | 1 |
Pathania, S | 1 |
Toomire, K | 1 |
Dimitrov, SD | 1 |
Liu, B | 1 |
Gelman, R | 1 |
Giobbie-Hurder, A | 1 |
Feunteun, J | 1 |
Polyak, K | 1 |
Livingston, DM | 1 |
Bruhn, KW | 1 |
Sarkissyan, S | 1 |
Heber, D | 1 |
Vadgama, JV | 1 |
Knouzy, B | 1 |
Dubourg, L | 1 |
Baverel, G | 1 |
Michoudet, C | 1 |
Fanelli, SL | 2 |
Maciel, ME | 3 |
Díaz Gómez, MI | 1 |
Delgado de Layño, AM | 2 |
Bietto, FM | 1 |
Castro, JA | 4 |
Castro, GD | 4 |
Sellers, TA | 1 |
Vierkant, RA | 1 |
Cerhan, JR | 1 |
Gapstur, SM | 1 |
Vachon, CM | 1 |
Olson, JE | 1 |
Pankratz, VS | 1 |
Kushi, LH | 1 |
Folsom, AR | 1 |
Otto, AM | 1 |
Grothe, H | 1 |
Motrescu, E | 1 |
Al-Maghrebi, MA | 1 |
Al-Mulla, F | 1 |
Benov, LT | 2 |
Singletary, KW | 1 |
Barnes, SL | 1 |
van Breemen, RB | 1 |
de Castro, CR | 1 |
de Ferreyra, EC | 1 |
Gómez, MI | 1 |
Al-Enezi, KS | 1 |
Alkhalaf, M | 1 |
Seitz, HK | 1 |
Becker, P | 1 |
Venkata, NG | 1 |
Aung, CS | 1 |
Cabot, PJ | 1 |
Monteith, GR | 1 |
Roberts-Thomson, SJ | 1 |
Ebeler, SE | 1 |
Clifford, AJ | 1 |
Shibamoto, T | 1 |
Börner, K | 1 |
Kisro, J | 1 |
Brüggemann, SK | 1 |
Hagenah, W | 1 |
Peters, SO | 1 |
Wagner, T | 1 |
Costantini, MH | 1 |
Henning, T | 1 |
Baumann, W | 1 |
Ehret, R | 1 |
Freund, I | 1 |
Kammerer, R | 1 |
Lehmann, M | 1 |
Schwinde, A | 1 |
4 reviews available for acetaldehyde and Breast Cancer
Article | Year |
---|---|
[Alcohol and breast cancer. A short survey].
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Breast Neoplasms; Carcinogens; DNA Damage; Et | 2018 |
Links between alcohol consumption and breast cancer: a look at the evidence.
Topics: Acetaldehyde; Adenocarcinoma; Alcohol Drinking; Breast Neoplasms; Estrogens; Ethanol; Female; Humans | 2015 |
Multiparametric sensor chips for chemosensitivity testing of sensitive and resistant tumor cells.
Topics: Acetaldehyde; Antibiotics, Antineoplastic; Biosensing Techniques; Breast Neoplasms; Drug Resistance, | 2003 |
Alcohol metabolism and cancer risk.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol-Induced Disorders; Aldehyde Dehydrogenase; Alleles; Bre | 2007 |
20 other studies available for acetaldehyde and Breast Cancer
Article | Year |
---|---|
Alcohol: Immunomodulatory Effects and Cancer.
Topics: Acetaldehyde; Alcohol Drinking; Breast Neoplasms; Ethanol; Female; Humans; Inflammation | 2023 |
Application of the optimized and validated LC-MS method for simultaneous quantification of tryptophan metabolites in culture medium from cancer cells.
Topics: Acetaldehyde; Breast Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Culture Medi | 2019 |
Alcohol and cancer: no threshold exists.
Topics: Acetaldehyde; Alcohol Abstinence; Alcohol Drinking; Alcoholic Beverages; Breast Neoplasms; Confidenc | 2020 |
Automated platform for sensor-based monitoring and controlled assays of living cells and tissues.
Topics: Acetaldehyde; Biosensing Techniques; Breast; Breast Neoplasms; Cell Line, Tumor; Cytotoxins; Electri | 2013 |
Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features.
Topics: Acetaldehyde; Breast; Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Epithelial Cell | 2016 |
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.
Topics: Acetaldehyde; BRCA1 Protein; Breast Neoplasms; Cell Differentiation; Cell Line; Cell Transformation, | 2016 |
Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features.
Topics: Acetaldehyde; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Epithelial-Mesenchymal Transitio | 2017 |
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7.
Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brea | 2010 |
Further studies on the potential contribution of acetaldehyde accumulation and oxidative stress in rat mammary tissue in the alcohol drinking promotion of breast cancer.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Breast Neoplasms; Ethanol; Female; Free Radicals; Oxidative | 2011 |
Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women.
Topics: Acetaldehyde; Aged; Alcohol Drinking; Breast Neoplasms; Cohort Studies; Female; Folic Acid; Folic Ac | 2002 |
Glycolaldehyde induces apoptosis in a human breast cancer cell line.
Topics: Acetaldehyde; Apoptosis; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Dose-Response Re | 2003 |
Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaldehyde; Benzo(a)pyrene; Breast Neoplasms; Cell Line, Tumor; Deoxy | 2004 |
Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Biotransformation; Breast; Breast Neoplasms; Cytosol; Ethan | 2004 |
Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: potential factors involved in alcohol drinking promotion of breast cancer.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaldehyde; Alcohol Drinking; Animals; Breast Neoplasms; Central Nerv | 2006 |
Glycolaldehyde induces growth inhibition and oxidative stress in human breast cancer cells.
Topics: Acetaldehyde; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; Lipid Pe | 2006 |
PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Breast Neoplasms; Cell Line, Tumor; C | 2008 |
Quantitative analysis by gas chromatography of volatile carbonyl compounds in expired air from mice and human.
Topics: Acetaldehyde; Acetone; Adult; Aged; Animals; Breast Neoplasms; Breath Tests; Carcinoma; Chromatograp | 1997 |
Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo.
Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Humans; Ifosfamide; Mice | 2000 |
Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Animals, Outbred Strains; Biotransformation; Breast; Breast | 2001 |
Approach to a multiparametric sensor-chip-based tumor chemosensitivity assay.
Topics: Acetaldehyde; Antibiotics, Antineoplastic; Biosensing Techniques; Breast Neoplasms; Doxorubicin; Dru | 2001 |