Page last updated: 2024-10-16

acetaldehyde and Atherosclerosis

acetaldehyde has been researched along with Atherosclerosis in 10 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.

Research Excerpts

ExcerptRelevanceReference
"Oxidized epitopes such as malondialdehyde-acetaldehyde (MAA) play a crucial role in the progression of atherosclerosis through activation of the humoral immune response."8.12Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth. ( Akhi, R; Buhlin, K; Hörkkö, S; Kyrklund, M; Mäntylä, P; Nissinen, AE; Paju, S; Pussinen, PJ; Sinisalo, J; Wang, C, 2022)
"Antibodies to malondialdehyde (MDA)-modified macromolecules (adducts) have been detected in the serum of patients with atherosclerosis and correlate with the progression of this disease."7.76Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis. ( Anderson, DR; Duryee, MJ; Garvin, RP; Hunter, CD; Klassen, LW; Schaffert, CS; Thiele, GM; Tuma, DJ, 2010)
"Oxidized epitopes such as malondialdehyde-acetaldehyde (MAA) play a crucial role in the progression of atherosclerosis through activation of the humoral immune response."4.12Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth. ( Akhi, R; Buhlin, K; Hörkkö, S; Kyrklund, M; Mäntylä, P; Nissinen, AE; Paju, S; Pussinen, PJ; Sinisalo, J; Wang, C, 2022)
"Antibodies to malondialdehyde (MDA)-modified macromolecules (adducts) have been detected in the serum of patients with atherosclerosis and correlate with the progression of this disease."3.76Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis. ( Anderson, DR; Duryee, MJ; Garvin, RP; Hunter, CD; Klassen, LW; Schaffert, CS; Thiele, GM; Tuma, DJ, 2010)
"Inflammation is widely accepted to play a major role in atherosclerosis and other cardiovascular diseases."2.52Aldehyde-modified proteins as mediators of early inflammation in atherosclerotic disease. ( Anderson, DR; Antoniak, DT; Duryee, MJ; Mikuls, TR; Thiele, GM, 2015)
"Inflammation is known to induce oxidative stress, which can lead to lipid peroxidation."1.62Malondialdehyde-Acetaldehyde Modified (MAA) Proteins Differentially Effect the Inflammatory Response in Macrophage, Endothelial Cells and Animal Models of Cardiovascular Disease. ( Anderson, DR; Clemens, DL; Duryee, LM; Duryee, MJ; Garvin, RP; Opperman, PJ; Thiele, GM, 2021)
"Treatment of periodontitis has beneficial effects on systemic inflammation markers that relate to progression of atherosclerosis."1.48Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein. ( Akhi, R; Hörkkö, S; Kankaanpää, J; Kummu, O; Kyrklund, M; Nissinen, A; Pussinen, P; Turunen, SP; Wang, C, 2018)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (70.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Duryee, MJ4
Clemens, DL1
Opperman, PJ1
Thiele, GM4
Duryee, LM1
Garvin, RP2
Anderson, DR4
Lomzenski, HE1
Chen, SC1
Ye, F1
Mikuls, TR2
Ormseth, MJ1
Akhi, R2
Nissinen, AE1
Wang, C3
Kyrklund, M2
Paju, S1
Mäntylä, P1
Buhlin, K1
Sinisalo, J1
Pussinen, PJ1
Hörkkö, S4
Kummu, O3
Kankaanpää, J1
Nissinen, A2
Turunen, SP3
Pussinen, P1
Tawakol, A1
Jaffer, F1
Ma, S1
Cao, F1
Prus, P1
Lehtimäki, J1
Veneskoski, M2
Antoniak, DT1
Klassen, LW1
Schaffert, CS1
Tuma, DJ1
Hunter, CD1
Rannikko, S1
Levonen, AL1

Reviews

2 reviews available for acetaldehyde and Atherosclerosis

ArticleYear
Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities.
    Advances in experimental medicine and biology, 2019, Volume: 1193

    Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Atherosclerosis; Humans

2019
Aldehyde-modified proteins as mediators of early inflammation in atherosclerotic disease.
    Free radical biology & medicine, 2015, Volume: 89

    Topics: Acetaldehyde; Atherosclerosis; Humans; Inflammation; Malondialdehyde

2015

Other Studies

8 other studies available for acetaldehyde and Atherosclerosis

ArticleYear
Malondialdehyde-Acetaldehyde Modified (MAA) Proteins Differentially Effect the Inflammatory Response in Macrophage, Endothelial Cells and Animal Models of Cardiovascular Disease.
    International journal of molecular sciences, 2021, Nov-30, Volume: 22, Issue:23

    Topics: Acetaldehyde; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Adhesion Molecules; Cells, Cul

2021
Serum anti-malondialdehyde-acetaldehyde IgA antibody concentration improves prediction of coronary atherosclerosis beyond traditional risk factors in patients with rheumatoid arthritis.
    Scientific reports, 2022, 06-22, Volume: 12, Issue:1

    Topics: Acetaldehyde; Arthritis, Rheumatoid; Atherosclerosis; Autoantibodies; C-Reactive Protein; Coronary A

2022
Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth.
    Oral diseases, 2022, Volume: 28, Issue:8

    Topics: Acetaldehyde; Aggregatibacter actinomycetemcomitans; Antigens, Bacterial; Atherosclerosis; Chaperoni

2022
Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Acetaldehyde; Adhesins, Bacterial; Animals; Antibodies, Bacterial; Atherosclerosis; Bacterial Protei

2018
Imaging the Intersection of Oxidative Stress, Lipids, and Inflammation: Progress Toward Personalized Care of Atherosclerosis.
    Journal of the American College of Cardiology, 2018, 01-23, Volume: 71, Issue:3

    Topics: Acetaldehyde; Atherosclerosis; Epitopes; Humans; Inflammation; Lipids; Magnetic Resonance Imaging; M

2018
Human monoclonal Fab and human plasma antibodies to carbamyl-epitopes cross-react with malondialdehyde-adducts.
    Immunology, 2014, Volume: 141, Issue:3

    Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Apoptosis; Atherosclerosis; Autoantibodies; Binding,

2014
Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis.
    Free radical biology & medicine, 2010, Nov-30, Volume: 49, Issue:10

    Topics: Acetaldehyde; Animals; Aorta; Atherosclerosis; Dihydropyridines; Epitopes; Male; Malondialdehyde; Mi

2010
Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a.
    Free radical biology & medicine, 2011, Aug-15, Volume: 51, Issue:4

    Topics: Acetaldehyde; Anaphylatoxins; Animals; Antibodies, Blocking; Apoptosis; Atherosclerosis; Cattle; Cel

2011