Page last updated: 2024-10-16

acetaldehyde and Alcoholic Intoxication

acetaldehyde has been researched along with Alcoholic Intoxication in 117 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Alcoholic Intoxication: An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.

Research Excerpts

ExcerptRelevanceReference
"The interaction between effects of ethanol ingestion and those of infrasound on neuro-muscular fatigue in the animal is abolished by ascorbic acid."7.66[Suppression by ascorbic acid of neuromuscular fatigue due to sound-alcohol synergy]. ( Busnel, RG; Lehmann, AG, 1978)
" Direct administration of acetate increased nociceptive behaviors suggesting that acetate, not acetaldehyde, accumulation results in hangover-like hypersensitivity in our model."3.76Acetate causes alcohol hangover headache in rats. ( Hoek, JB; Maxwell, CR; Oshinsky, ML; Silberstein, SD; Spangenberg, RJ, 2010)
"The correlation among degrees of alcohol intoxication, facial flushing, blood alcohol concentration (BAC) and blood acetaldehyde level was studied in 117 male alcoholic patients who underwent various tests to assess alcohol influence."3.68Degrees of alcohol intoxication in 117 hospitalized cases. ( Adachi, J; Fukunaga, T; Imamichi, H; Mizoi, Y; Ogawa, Y; Ueno, Y, 1991)
"Alcohol-sensitive Japanese subjects with facial flushing and an increase in heart rate during ethanol intoxication exhibited marked individual variation in accumulation of acetaldehyde."3.67Suppression of acetaldehyde accumulation by 4-methylpyrazole in alcohol-hypersensitive Japanese. ( Inoue, K; Kera, Y; Kiriyama, T; Komura, S, 1985)
"The interaction between effects of ethanol ingestion and those of infrasound on neuro-muscular fatigue in the animal is abolished by ascorbic acid."3.66[Suppression by ascorbic acid of neuromuscular fatigue due to sound-alcohol synergy]. ( Busnel, RG; Lehmann, AG, 1978)
"A hereditary element to alcohol dependence has been suggested by several adoption and twin studies, but the many contradictions between research results emphasise that any genetic contribution is overshadowed by socio-cultural factors."2.37Psychiatric advances in the understanding and treatment of alcohol dependence. ( Madden, JS, 1984)
" About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes."1.56Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity. ( Barrientos, FL; Cervantes, PR; Chen, CH; Ferreira, JCB; Ferreira, ND; Hsu, JH; Joshi, AU; Li, SJ; Maclean, R; Martinez, DD; Mochly-Rosen, D; Quintanares, GHR; Stevens, MC, 2020)
"The mechanism of veisalgia cephalgia or hangover headache is unknown."1.36Acetate causes alcohol hangover headache in rats. ( Hoek, JB; Maxwell, CR; Oshinsky, ML; Silberstein, SD; Spangenberg, RJ, 2010)
"It also prolonged drunkenness by enhancing the neurodepressive effects of ethanol, due to increases in the amount of nonvolatile congeners."1.34Maturation of whisky changes ethanol elimination kinetics and neural effects by increasing nonvolatile congeners. ( Haseba, T; Mashimo, K; Ohno, Y; Sato, S; Sugimoto, J, 2007)
"Alcohol addiction was diagnosed according to ICD-10 criteria."1.32[Acetaldehyde concentration in acute ethanol-intoxicated patients addicted to alcohol]. ( Gawlikowski, T; Gomółka, E; Król, A; Piekoszewski, W, 2004)
"Acetaldehyde treatment alone caused no significant inhibition of protein synthesis."1.29The acute effects of ethanol and acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum. ( Marway, JS; Preedy, VR, 1995)
"Facial flushing was recognized in 75% of the subjects."1.28Degrees of alcohol intoxication in 117 hospitalized cases. ( Adachi, J; Fukunaga, T; Imamichi, H; Mizoi, Y; Ogawa, Y; Ueno, Y, 1991)
" Therefore, a new pharmacokinetic model takes into account Michaelis-Menten-elimination kinetics of ethanol as well as kinetics of acetaldehyde and acetate, which are defined by first order processes."1.28[New methods of pharmacokinetic evaluation of alcohol and its metabolites in female and male probands]. ( Bitsch, I; Kohlenberg-Müller, K, 1990)
"When acetaldehyde was added first, ethanol production was inhibited the next day, but on and after day 2, the quantity of ethanol was more than that in the control material."1.27Experimental studies on the mechanism of ethanol formation in corpses. ( Hashimoto, Y; Moriya, F; Nanikawa, R, 1988)
"Acetaldehyde was found in circulation following ethanol intoxication or was present after direct i."1.27Effect of acetaldehyde on rat platelet aggregation in vivo and in vitro. ( Bengmark, S; Zoucas, E, 1987)
"Blood AcH in occasional or chronic alcohol abusers were generally low (< 10 microM), elevated AcH levels being observed only in association with clinical abnormalities."1.26Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods. ( Hillbom, M; Lindros, KO; Salaspuro, M; Stowell, A, 1980)
" We present 2 illustrative cases, discuss the acute toxicity of ethanol, and present 2 simple calculating charts for dosage and kinetics."1.26The acute toxicity of ethanol: dosage and kinetic nomograms. ( David, DJ; Spyker, DA, 1979)
" At low infusion dosage when the EEG was unaffected, concentrations of acetaldehyde in the blood were equal to or greater than those which occur during intoxication."1.26Evidence against a role of acetaldehyde in electroencephalographic signs of ethanol-induced intoxication. ( Klemm, WR; Mikeska, JA, 1979)

Research

Studies (117)

TimeframeStudies, this research(%)All Research%
pre-199066 (56.41)18.7374
1990's25 (21.37)18.2507
2000's14 (11.97)29.6817
2010's9 (7.69)24.3611
2020's3 (2.56)2.80

Authors

AuthorsStudies
Li, S2
Zheng, Y1
Xiao, L1
Lan, S1
Xiang, J1
Liao, L1
Lin, Y1
Ye, Y1
Kim, KJ1
Park, SY1
Park, TG1
Park, HJ1
Kim, YJ1
Kim, EJ1
Shin, W1
Kim, A1
Yoo, H1
Kweon, M1
Jang, J1
Choi, SY1
Kim, JY1
Chen, CH1
Ferreira, JCB1
Joshi, AU1
Stevens, MC1
Li, SJ1
Hsu, JH1
Maclean, R1
Ferreira, ND1
Cervantes, PR1
Martinez, DD1
Barrientos, FL1
Quintanares, GHR1
Mochly-Rosen, D1
Alexandrovich, YG1
Kosenko, EA1
Sinauridze, EI1
Obydennyi, SI1
Kireev, II1
Ataullakhanov, FI1
Kaminsky, YG1
Lee, MH1
Kwak, JH1
Jeon, G1
Lee, JW1
Seo, JH1
Lee, HS2
Lee, JH1
Bébarová, M1
Matejovič, P1
Šimurdová, M1
Šimurda, J1
Zhao, Y1
Sun, J1
Hu, J1
Bo, N1
Yu, B1
Zhang, YJ1
Wang, F1
Zhou, Y1
Li, Y1
Zhou, T1
Zheng, J1
Zhang, JJ1
Xu, DP1
Li, HB1
Yokoyama, A1
Kamada, Y1
Imazeki, H1
Hayashi, E1
Murata, S1
Kinoshita, K1
Yokoyama, T1
Kitagawa, Y1
Venkataranganna, MV1
Gopumadhavan, S1
Sundaram, R1
Peer, G1
Mitra, SK1
Kanteres, F1
Lachenmeier, DW1
Rehm, J1
Song, J1
Kim, TM1
Joo, SS1
Park, D1
Jeon, JH1
Shin, S1
Park, HK1
Lee, WK1
Ly, SY1
Kim, MR1
Lee, DI1
Kim, YB1
Min, JA1
Lee, K1
Ki, DJ1
Maxwell, CR1
Spangenberg, RJ1
Hoek, JB1
Silberstein, SD1
Oshinsky, ML1
Amireche, N1
Petit, JS1
Bankole, E1
Fournet-Fayard, A1
Appriou, M1
Leon, A1
Smith, D1
Wang, T1
Spanĕl, P1
ALHA, AR1
HJELT, E1
TAMMINEN, V1
MIZOI, Y4
OHGA, N1
ROMANO, C1
LECOQ, R1
Gawlikowski, T1
Piekoszewski, W2
Gomółka, E1
Król, A1
Izco, M1
Orio, L1
O'Shea, E1
Colado, MI1
Haseba, T2
Mashimo, K1
Sugimoto, J1
Sato, S1
Ohno, Y1
Chmiest, W1
Targosz, D1
Gawlikowsk, T1
McGregor, NR1
Beck, O2
Thomas, M1
Lim, CK1
Peters, TJ1
Kobayashi, M1
Watanabe, A1
Hobara, N1
Nakatsukasa, H1
Nagashima, H1
Fujimoto, A1
Kupari, M1
Lindros, K1
Hillbom, M3
Heikkilä, J1
Ylikahri, R1
Tatsuno, Y1
Adachi, J2
Kogame, M1
Fukunaga, T9
Fujiwara, S1
Hishida, S1
Ijiri, I1
Madden, JS1
Nuutinen, HU1
Salaspuro, MP1
Valle, M1
Lindros, KO3
Jones, AW3
Skagerberg, S1
Borg, S1
Anggård, E1
Inoue, K2
Fukunaga, M1
Ohbora, Y1
Kiriyama, T2
Komura, S3
Eriksson, CJ10
Sadovnik, MN1
Satanovskaya, VI1
Selevich, MI1
Buko, VU1
Lelevich, VI1
Lukashik, NK1
Tuma, DJ1
Sorrell, MF1
Borisenko, SA1
Tolmacheva, NS1
Burov, IuV1
Blinkova, NF1
Hillbom, ME3
Tervo, TM1
Messiha, FS1
Schuckit, MA1
Sovijärvi, AR1
Stowell, A1
Salaspuro, M1
Marway, JS1
Preedy, VR1
Wickramasinghe, SN2
Mawas, F1
Hasan, R1
Brown, IN1
Goldin, RD1
Sillanaukee, P2
Kitazawa, M1
Tsukamoto, S4
Kanegae, T4
Tie, J1
Kaneko, Y1
Shiratori, R1
Oshida, S1
Gerashchenko, D1
Gorenshtein, B1
Pyzhik, T1
Ostrovsky, Yu1
Sarkola, T1
Lindholm, H1
Ahola, L1
Whitmire, D1
Cornelius, LM1
Whitmire, PS1
Kakuda, T1
Sakane, I1
Takihara, T1
Nagoya, T3
Sessa, A1
Tunici, P1
Rabellotti, E1
Perin, A1
Washizuka, M1
Hiraga, Y1
Furuichi, H1
Izumi, J1
Yoshinaga, K1
Abe, T1
Tanaka, Y1
Tamaki, H1
Loguercio, C1
Clot, P1
Albano, E1
Argenzio, F1
Grella, A1
De Girolamo, V1
Delle Cave, M1
Del Vecchio Bianco, C1
Nardi, G1
Laposata, M1
Yamamoto, H1
Tanegashima, A1
Hosoe, H1
Nishimura, FT1
Nishijo, H1
Ono, T1
Kajiura And, H1
Yokomukai, Y1
Sharpe, PC1
Zuba, D1
Pach, J1
Winnik, L1
Parczewski, A1
Busnel, RG1
Lehmann, AG1
Bing, RJ1
Hasumura, Y2
Teschke, R2
Lieber, CS3
Majchrowicz, E3
Hunt, WA1
Lahti, RA2
Ogata, M1
Karoum, F1
DeCarli, LM1
Feinman, L1
Korsten, M1
Matsuzaki, S1
David, DJ1
Spyker, DA1
LaManna, JC1
Younts, BW1
Rosenthal, M1
Macdonald, CM1
Dow, J1
Moore, MR2
Tottmar, O1
Marchner, H1
Karlsson, N1
Mikeska, JA1
Klemm, WR1
Marr, JJ1
Spilberg, I1
Dembiec, D1
MacNamee, D1
Cohen, G1
Ewing, JA1
Rouse, BA1
Mueller, RA1
Mills, KC1
Collins, MA2
Bigdeli, MG2
Gill, K1
Menez, JF1
Lucas, D1
Deitrich, RA1
Skrzydlewska, E2
Worowski, K2
Roszkowska-Jakimiec, W1
Saito, M1
Shimamura, M2
Tainaka, H1
Kawaguchi, M1
Schuberth, J1
Ogawa, Y1
Ueno, Y1
Imamichi, H1
Magnani, M1
Laguerre, M1
Rossi, L1
Bianchi, M1
Ninfali, P1
Mangani, F1
Ropars, C1
Niemelä, O1
Israel, Y1
Mieda, Y1
Nomura, M1
Hojo, K1
Okubo, H1
Kohlenberg-Müller, K1
Bitsch, I1
Tomita, Y1
Kurosu, M1
Watanabe, T1
Hernández-Muñoz, R1
Baraona, E1
Blacksberg, I1
Uysal, M1
Ozdemirler, G1
Kutalp, G1
Oz, H1
Nordmann, R1
Kukiełka, E1
Nanikawa, R1
Moriya, F1
Hashimoto, Y1
Neiman, J1
Benthin, G1
Löwbeer, C1
Tyler, A1
Faull, K1
Zoucas, E1
Bengmark, S1
João, SR1
Ohtake, H1
Kato, S1
Murawaki, Y1
Kishimoto, Y1
Wakushima, T1
Hirayama, C1
Malik, F1
Skrzydlewski, Z1
Kera, Y1
O'Keane, M1
Smith, S1
Goldberg, A2
Egaña, E1
Rodrigo, R1
Gordon, R1
Rubenstein, JA1
Ezrielev, GI1
Ylikahri, RH1
Huttunen, MO1
Nikkilä, EA1
Mendelson, JH2
Damrau, F1
Goldberg, AH1
Tamura, T1
Inoue, H1
Iida, T1
Ono, H1
Lester, D1
Benson, GD1
Wilson, AS1
Barboriak, JJ1
Kass, WA1
Beattie, AD1
Thompson, GG1
Ueda, M1
Fukui, Y1
Yamamoto, K1
Kobayashi, T1
Murphree, HB1
Price, LM1
Greenberg, LA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of β-nicotinamide Mononucleotide Intervention on Healthy Young Subjects With Acute Binge Drink: a Double-blinded, Randomized, Crossover Trial[NCT05882214]20 participants (Anticipated)Interventional2023-12-31Recruiting
Evaluation of a Fixed Combination of Herbal Extracts to Prevent Symptoms Alcohol-induced Hangovers : A Randomized, Double Blind Placebo Controlled Crossover Study.[NCT04183842]40 participants (Actual)Interventional2019-07-04Completed
A Phase IIa, Prospective, Randomized, Blinded, Intra-Subject Controlled, Single Dose, Dose Escalation Study of Antizol® for Mitigation of Acetaldehyde Related Toxicity in Human Subjects With Symptoms of Inborn Altered Ethanol Metabolism With Concomitant E[NCT00661141]Phase 232 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Pharmacokinetics (PK) of 4-MP: Maximum Plasma Concentration (Cmax)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionng/mL (Mean)
1.0 mg/kg Antizol Followed by Ethanol2386
Ethanol Followed by 1.0 mg/kg Antizol1358
3.0 mg/kg Antizol Followed by Ethanol5605
Ethanol Followed by 3.0 mg/kg Antizol4680
5.0 mg/kg Antizol Followed by Ethanol8623

PK of 4-MP: Apparent Clearance (CL/F)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionL/hr (Mean)
1.0 mg/kg Antizol Followed by Ethanol6.70
Ethanol Followed by 1.0 mg/kg Antizol8.23
3.0 mg/kg Antizol Followed by Ethanol3.15
Ethanol Followed by 3.0 mg/kg Antizol2.99
5.0 mg/kg Antizol Followed by Ethanol2.35

PK of 4-MP: Apparent Volume of Distribution During Terminal Phase (Vz/F)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionLiters (Mean)
1.0 mg/kg Antizol Followed by Ethanol26.3
Ethanol Followed by 1.0 mg/kg Antizol24.7
3.0 mg/kg Antizol Followed by Ethanol24.4
Ethanol Followed by 3.0 mg/kg Antizol24.9
5.0 mg/kg Antizol Followed by Ethanol24.7

PK of 4-MP: Area Under the Plasma Concentration-Time Curve (AUC), Calculated to the Last Measured Concentration (AUC[0-t])

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionng*hr/mL (Mean)
1.0 mg/kg Antizol Followed by Ethanol13804
Ethanol Followed by 1.0 mg/kg Antizol7409
3.0 mg/kg Antizol Followed by Ethanol44942
Ethanol Followed by 3.0 mg/kg Antizol34310
5.0 mg/kg Antizol Followed by Ethanol109298

PK of 4-MP: AUC, From Time 0 Extrapolated to Infinite Time (AUC[0-∞])

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionng*hr/mL (Mean)
1.0 mg/kg Antizol Followed by Ethanol11035
Ethanol Followed by 1.0 mg/kg Antizol7627
3.0 mg/kg Antizol Followed by Ethanol55452
Ethanol Followed by 3.0 mg/kg Antizol57028
5.0 mg/kg Antizol Followed by Ethanol136871

PK of 4-MP: DN AUC(0-∞)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Intervention(ng*hr/mL)/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol149
Ethanol Followed by 1.0 mg/kg Antizol122
3.0 mg/kg Antizol Followed by Ethanol317
Ethanol Followed by 3.0 mg/kg Antizol334
5.0 mg/kg Antizol Followed by Ethanol460

PK of 4-MP: DN AUC(0-t)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Intervention(ng*hr/mL)/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol223
Ethanol Followed by 1.0 mg/kg Antizol103
3.0 mg/kg Antizol Followed by Ethanol231
Ethanol Followed by 3.0 mg/kg Antizol204
5.0 mg/kg Antizol Followed by Ethanol378

PK of 4-MP: Dose-Normalized (DN) Cmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Intervention(ng/mL)/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol38.3
Ethanol Followed by 1.0 mg/kg Antizol18.9
3.0 mg/kg Antizol Followed by Ethanol27.6
Ethanol Followed by 3.0 mg/kg Antizol28.0
5.0 mg/kg Antizol Followed by Ethanol30.2

PK of 4-MP: Half-Life (T1/2)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionhours (Mean)
1.0 mg/kg Antizol Followed by Ethanol2.72
Ethanol Followed by 1.0 mg/kg Antizol3.11
3.0 mg/kg Antizol Followed by Ethanol5.37
Ethanol Followed by 3.0 mg/kg Antizol5.76
5.0 mg/kg Antizol Followed by Ethanol9.26

PK of 4-MP: Percentage of AUC0-∞ Obtained by Extrapolation (AUC%Extrap)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionpercentage (Mean)
1.0 mg/kg Antizol Followed by Ethanol16.8
Ethanol Followed by 1.0 mg/kg Antizol13.0
3.0 mg/kg Antizol Followed by Ethanol3.31
Ethanol Followed by 3.0 mg/kg Antizol4.37
5.0 mg/kg Antizol Followed by Ethanol13.2

PK of 4-MP: Time to Cmax (Tmax)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionhours (Median)
1.0 mg/kg Antizol Followed by Ethanol1.00
Ethanol Followed by 1.0 mg/kg Antizol2.50
3.0 mg/kg Antizol Followed by Ethanol0.667
Ethanol Followed by 3.0 mg/kg Antizol1.48
5.0 mg/kg Antizol Followed by Ethanol1.00

PK of Acetaldehyde: AUC(0-∞)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionµM*hr (Mean)
1.0 mg/kg Antizol Followed by Ethanol234
Ethanol Followed by 1.0 mg/kg Antizol154
3.0 mg/kg Antizol Followed by Ethanol297
Ethanol Followed by 3.0 mg/kg Antizol302
5.0 mg/kg Antizol Followed by Ethanol188
Placebo Followed by Ethanol205
Ethanol Followed by Placebo227

PK of Acetaldehyde: AUC(0-t)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionµM*hr (Mean)
1.0 mg/kg Antizol Followed by Ethanol178
Ethanol Followed by 1.0 mg/kg Antizol118
3.0 mg/kg Antizol Followed by Ethanol155
Ethanol Followed by 3.0 mg/kg Antizol167
5.0 mg/kg Antizol Followed by Ethanol128
Placebo Followed by Ethanol163
Ethanol Followed by Placebo139

PK of Acetaldehyde: AUC%Extrap

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionpercentage (Mean)
1.0 mg/kg Antizol Followed by Ethanol19.0
Ethanol Followed by 1.0 mg/kg Antizol18.8
3.0 mg/kg Antizol Followed by Ethanol13.1
Ethanol Followed by 3.0 mg/kg Antizol9.78
5.0 mg/kg Antizol Followed by Ethanol24.7
Placebo Followed by Ethanol13.7
Ethanol Followed by Placebo14.5

PK of Acetaldehyde: Cmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionµM (Mean)
1.0 mg/kg Antizol Followed by Ethanol59.6
Ethanol Followed by 1.0 mg/kg Antizol37.6
3.0 mg/kg Antizol Followed by Ethanol50.9
Ethanol Followed by 3.0 mg/kg Antizol55.9
5.0 mg/kg Antizol Followed by Ethanol40.0
Placebo Followed by Ethanol60.3
Ethanol Followed by Placebo42.7

PK of Acetaldehyde: DN AUC(0-∞)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionµM*hr/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol0.00682
Ethanol Followed by 1.0 mg/kg Antizol0.00432
3.0 mg/kg Antizol Followed by Ethanol0.00929
Ethanol Followed by 3.0 mg/kg Antizol0.0105
5.0 mg/kg Antizol Followed by Ethanol0.00626
Placebo Followed by Ethanol0.00616
Ethanol Followed by Placebo0.00752

PK of Acetaldehyde: DN AUC(0-t)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionµM*hr/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol0.00547
Ethanol Followed by 1.0 mg/kg Antizol0.00329
3.0 mg/kg Antizol Followed by Ethanol0.00470
Ethanol Followed by 3.0 mg/kg Antizol0.00597
5.0 mg/kg Antizol Followed by Ethanol0.00439
Placebo Followed by Ethanol0.00521
Ethanol Followed by Placebo0.00455

PK of Acetaldehyde: DN Cmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventionµM/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol0.00181
Ethanol Followed by 1.0 mg/kg Antizol0.00104
3.0 mg/kg Antizol Followed by Ethanol0.00157
Ethanol Followed by 3.0 mg/kg Antizol0.00201
5.0 mg/kg Antizol Followed by Ethanol0.00138
Placebo Followed by Ethanol0.00193
Ethanol Followed by Placebo0.00141

PK of Acetaldehyde: T1/2

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionhours (Mean)
1.0 mg/kg Antizol Followed by Ethanol3.14
Ethanol Followed by 1.0 mg/kg Antizol3.08
3.0 mg/kg Antizol Followed by Ethanol2.48
Ethanol Followed by 3.0 mg/kg Antizol1.72
5.0 mg/kg Antizol Followed by Ethanol3.45
Placebo Followed by Ethanol2.39
Ethanol Followed by Placebo2.09

PK of Acetaldehyde: Tmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionhours (Median)
1.0 mg/kg Antizol Followed by Ethanol0.500
Ethanol Followed by 1.0 mg/kg Antizol0.650
3.0 mg/kg Antizol Followed by Ethanol1.00
Ethanol Followed by 3.0 mg/kg Antizol1.33
5.0 mg/kg Antizol Followed by Ethanol0.500
Placebo Followed by Ethanol0.500
Ethanol Followed by Placebo0.925

PK of Ethanol: AUC(0-∞)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionmg*hr/mL (Mean)
1.0 mg/kg Antizol Followed by Ethanol245
Ethanol Followed by 1.0 mg/kg Antizol263
3.0 mg/kg Antizol Followed by Ethanol237
Ethanol Followed by 3.0 mg/kg Antizol215
5.0 mg/kg Antizol Followed by Ethanol271
Placebo Followed by Ethanol214
Ethanol Followed by Placebo198

PK of Ethanol: AUC(0-t)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionmg*hr/dL (Mean)
1.0 mg/kg Antizol Followed by Ethanol209
Ethanol Followed by 1.0 mg/kg Antizol209
3.0 mg/kg Antizol Followed by Ethanol205
Ethanol Followed by 3.0 mg/kg Antizol135
5.0 mg/kg Antizol Followed by Ethanol231
Placebo Followed by Ethanol157
Ethanol Followed by Placebo152

PK of Ethanol: AUC%Extrap

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionpercentage (Mean)
1.0 mg/kg Antizol Followed by Ethanol14.7
Ethanol Followed by 1.0 mg/kg Antizol20.5
3.0 mg/kg Antizol Followed by Ethanol13.2
Ethanol Followed by 3.0 mg/kg Antizol20.0
5.0 mg/kg Antizol Followed by Ethanol12.1
Placebo Followed by Ethanol13.4
Ethanol Followed by Placebo13.9

PK of Ethanol: CL/F

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventiondL/hr (Mean)
1.0 mg/kg Antizol Followed by Ethanol140
Ethanol Followed by 1.0 mg/kg Antizol138
3.0 mg/kg Antizol Followed by Ethanol142
Ethanol Followed by 3.0 mg/kg Antizol131
5.0 mg/kg Antizol Followed by Ethanol112
Placebo Followed by Ethanol159
Ethanol Followed by Placebo167

PK of Ethanol: Cmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionmg/dL (Mean)
1.0 mg/kg Antizol Followed by Ethanol62.7
Ethanol Followed by 1.0 mg/kg Antizol70.3
3.0 mg/kg Antizol Followed by Ethanol80.5
Ethanol Followed by 3.0 mg/kg Antizol43.3
5.0 mg/kg Antizol Followed by Ethanol74.9
Placebo Followed by Ethanol59.3
Ethanol Followed by Placebo55.1

PK of Ethanol: DN AUC(0-∞)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Intervention(mg*hr/dL)/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol0.00760
Ethanol Followed by 1.0 mg/kg Antizol0.00731
3.0 mg/kg Antizol Followed by Ethanol0.00705
Ethanol Followed by 3.0 mg/kg Antizol0.00768
5.0 mg/kg Antizol Followed by Ethanol0.00917
Placebo Followed by Ethanol0.00681
Ethanol Followed by Placebo0.00617

PK of Ethanol: DN AUC(0-t)

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Intervention(mg*hr/dL)/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol0.00648
Ethanol Followed by 1.0 mg/kg Antizol0.00585
3.0 mg/kg Antizol Followed by Ethanol0.00613
Ethanol Followed by 3.0 mg/kg Antizol0.00483
5.0 mg/kg Antizol Followed by Ethanol0.00791
Placebo Followed by Ethanol0.00508
Ethanol Followed by Placebo0.00476

PK of Ethanol: DN Cmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Intervention(mg/dL)/mg (Mean)
1.0 mg/kg Antizol Followed by Ethanol0.00195
Ethanol Followed by 1.0 mg/kg Antizol0.00198
3.0 mg/kg Antizol Followed by Ethanol0.00243
Ethanol Followed by 3.0 mg/kg Antizol0.00155
5.0 mg/kg Antizol Followed by Ethanol0.00261
Placebo Followed by Ethanol0.00193
Ethanol Followed by Placebo0.00175

PK of Ethanol: T1/2

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionhours (Mean)
1.0 mg/kg Antizol Followed by Ethanol1.51
Ethanol Followed by 1.0 mg/kg Antizol1.95
3.0 mg/kg Antizol Followed by Ethanol1.43
Ethanol Followed by 3.0 mg/kg Antizol1.78
5.0 mg/kg Antizol Followed by Ethanol1.67
Placebo Followed by Ethanol1.45
Ethanol Followed by Placebo1.32

PK of Ethanol: Tmax

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

Interventionhours (Median)
1.0 mg/kg Antizol Followed by Ethanol1.50
Ethanol Followed by 1.0 mg/kg Antizol0.833
3.0 mg/kg Antizol Followed by Ethanol0.500
Ethanol Followed by 3.0 mg/kg Antizol1.42
5.0 mg/kg Antizol Followed by Ethanol0.500
Placebo Followed by Ethanol0.500
Ethanol Followed by Placebo1.01

PK of Ethanol: Vz/F

(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment

InterventiondL (Mean)
1.0 mg/kg Antizol Followed by Ethanol297
Ethanol Followed by 1.0 mg/kg Antizol387
3.0 mg/kg Antizol Followed by Ethanol295
Ethanol Followed by 3.0 mg/kg Antizol330
5.0 mg/kg Antizol Followed by Ethanol242
Placebo Followed by Ethanol287
Ethanol Followed by Placebo321

Number of Participants With Adverse Events (AEs), Serious AEs, and AEs Leading to Study Discontinuation

AEs were collected to evaluate the safety and tolerability of oral Antizol with concomitant ethanol administration in particitpants with symptoms of acetaldehyde toxicity associated with altered ethanol metabolism. AE: any untoward medical event that occurs following the first administration of study medication until the study participant's last study visit, whether or not the event is considered drug related. SAE: an event that meets any of the following criteria: results in death; is life threatening; requires inpatient hospitalization or prolongation of an existing hospitalization; results in persistent or significant disability/incapacity; is a congenital anomaly/birth defect in the offspring of an exposed subject; is medically significant or an important medical event as assessed by investigator or sponsor; is, in the opinion of the investigator, an important medical event. (NCT00661141)
Timeframe: Study Day 0 through Study Visit Day 7

,,,,
InterventionParticipants (Count of Participants)
Any AEMild AEModerate AESevere AELife-Threatening/Disabling AEDeathPossibly or Probably Related AEAE Leading to Study DiscontinuationSerious AE
Antizol 1.0 mg/kg131320001300
Antizol 3.0 mg/kg660000600
Antizol 5.0 mg/kg880000500
Overall282870002700
Pooled Placebo211950001800

Reviews

15 reviews available for acetaldehyde and Alcoholic Intoxication

ArticleYear
The application of minerals in managing alcohol hangover: a preliminary review.
    Current drug abuse reviews, 2010, Volume: 3, Issue:2

    Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Intoxication; Cytokines; Ethanol; Humans; Inflammation; Mi

2010
Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk.
    Alcohol (Fayetteville, N.Y.), 2007, Volume: 41, Issue:7

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Aldehyd

2007
Psychiatric advances in the understanding and treatment of alcohol dependence.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1984, Volume: 19, Issue:4

    Topics: Acetaldehyde; Adoption; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcoholism; Antidepressive

1984
Measuring and reporting the concentration of acetaldehyde in human breath.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1995, Volume: 30, Issue:3

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Breath Tests; Ethanol; Humans; Predictive Value of

1995
Human blood acetaldehyde (update 1992).
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1993, Volume: 2

    Topics: Acetaldehyde; Alcoholic Intoxication; Binding Sites; Blood Cells; Blood Chemical Analysis; Blood Pro

1993
Assessment of ethanol intake. Current tests and new assays on the horizon.
    American journal of clinical pathology, 1999, Volume: 112, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Biomarkers; Chromatography, Gas; Ethanol; Glycerophospholipids

1999
The role of acetaldehyde in the actions of alcohol (update 2000).
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:5 Suppl IS

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcohol-Induced Disorders; Alcoholic Intoxica

2001
Biochemical detection and monitoring of alcohol abuse and abstinence.
    Annals of clinical biochemistry, 2001, Volume: 38, Issue:Pt 6

    Topics: Acetaldehyde; Alanine Transaminase; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Aspartate

2001
Cardiac metabolsim: its contributions to alcoholic heart disease and myocardial failure.
    Circulation, 1978, Volume: 58, Issue:6

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Calcium; Calcium-Transporting ATPases; Cardiomyopathy

1978
The metabolism of biogenic amines in experimental animals and in human subjects during acute and chronic administration of ethanol.
    Advances in experimental medicine and biology, 1977, Volume: 85A

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Aldehyde Oxidoreductases; Animals; Biogenic Amines

1977
Effect of chronic alcohol consumption on ethanol and acetaldehyde metabolism.
    Advances in experimental medicine and biology, 1975, Volume: 59

    Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohols; Amitrole; Animals; Catalase

1975
[Metabolism of liver proteins in ethanol poisoning].
    Postepy higieny i medycyny doswiadczalnej, 1992, Volume: 46, Issue:1

    Topics: Acetaldehyde; Albumins; Alcoholic Intoxication; Animals; Collagen; Disease Models, Animal; Dose-Resp

1992
International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper No. 15/3. Human acetaldehyde levels: aspects of current interest.
    Mutation research, 1987, Volume: 186, Issue:3

    Topics: Acetaldehyde; Alcoholic Intoxication; Ethanol; Humans; Mutagens; Protein Binding

1987
Some biochemical effects of ethanol on CNS.
    International journal of neurology, 1974, Volume: 9, Issue:2

    Topics: Acetaldehyde; Acetylcholine; Alcohol Oxidoreductases; Alcoholic Intoxication; Aminobutyrates; Animal

1974
Biologic concomitants of alcoholism. 1.
    The New England journal of medicine, 1970, Jul-02, Volume: 283, Issue:1

    Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcoholism; Animals; Blood Glucose; C

1970

Trials

4 trials available for acetaldehyde and Alcoholic Intoxication

ArticleYear
Noni fruit extract ameliorates alcohol-induced hangover symptoms by reducing the concentrations of alcohol and acetaldehyde in a Sprague Dawley rat model and a human intervention study.
    Food & function, 2023, Feb-06, Volume: 14, Issue:3

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Animals; Ethanol; Fruit; Humans; Morinda; Plant Extract

2023
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
    Food & function, 2014, Volume: 5, Issue:3

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant

2014
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
    Food & function, 2014, Volume: 5, Issue:3

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant

2014
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
    Food & function, 2014, Volume: 5, Issue:3

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant

2014
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
    Food & function, 2014, Volume: 5, Issue:3

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant

2014
Estrogen-related acetaldehyde elevation in women during alcohol intoxication.
    Alcoholism, clinical and experimental research, 1996, Volume: 20, Issue:7

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Contraceptives, Oral; Estradiol; Estr

1996
Metabolic studies on the pathogenesis of hangover.
    European journal of clinical investigation, 1974, Volume: 4, Issue:2

    Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Intoxication; Ethanol; Fatty Acids, Nonesterified; Glucosi

1974

Other Studies

98 other studies available for acetaldehyde and Alcoholic Intoxication

ArticleYear
Aldehyde dehydrogenase 2-associated changes in pharmacokinetics, locomotor function and peripheral glutamic acid and gamma-aminobutyric acid levels during acute alcohol intoxication in male mice.
    Behavioural pharmacology, 2022, 12-01, Volume: 33, Issue:8

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial; Animals; Blood Alcohol

2022
Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity.
    EBioMedicine, 2020, Volume: 55

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial; Animals; Asian People;

2020
Rapid Elimination of Blood Alcohol Using Erythrocytes: Mathematical Modeling and In Vitro Study.
    BioMed research international, 2017, Volume: 2017

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Erythrocytes; E

2017
Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current I(K1) in rat ventricular myocytes.
    Physiological research, 2015, Volume: 64, Issue:6

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Pota

2015
[Effect of ethanol and its metabolites on acetylcholine-sensitive K(+) channel Kir3.1 protein expression of neonatal rat primary atrial cardiomyocytes].
    Zhonghua xin xue guan bing za zhi, 2015, Volume: 43, Issue:7

    Topics: Acetaldehyde; Acetylcholine; Alcoholic Intoxication; Animals; Apoptosis; Cells, Cultured; Ethanol; G

2015
Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts.
    International journal of environmental research and public health, 2016, Apr-01, Volume: 13, Issue:4

    Topics: Acetaldehyde; Alanine Transaminase; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Oxidored

2016
Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:6

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial;

2016
Pharmacodynamics & toxicological profile of PartySmart, a herbal preparation for alcohol hangover in Wistar rats.
    The Indian journal of medical research, 2008, Volume: 127, Issue:5

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Animals; Dose-Response Relationship, Dr

2008
Alcohol in Mayan Guatemala: consumption, distribution, production and composition of cuxa.
    Addiction (Abingdon, England), 2009, Volume: 104, Issue:5

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Cult

2009
Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover.
    Journal of medicinal food, 2009, Volume: 12, Issue:6

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Cytoch

2009
Acetate causes alcohol hangover headache in rats.
    PloS one, 2010, Dec-31, Volume: 5, Issue:12

    Topics: Acetaldehyde; Acetates; Alcohol Drinking; Alcoholic Intoxication; Analgesia; Animals; Chronic Diseas

2010
[A serious "acetaldehyde syndrome" compounded by dopamine].
    Annales francaises d'anesthesie et de reanimation, 2011, Volume: 30, Issue:2

    Topics: Acetaldehyde; Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Anti-Anxiety Agents; Antidepre

2011
On-line, simultaneous quantification of ethanol, some metabolites and water vapour in breath following the ingestion of alcohol.
    Physiological measurement, 2002, Volume: 23, Issue:3

    Topics: Acetaldehyde; Acetone; Alcoholic Intoxication; Ammonia; Breath Tests; Central Nervous System Depress

2002
Disulfiram-alcohol intoxication; investigation of five fatal cases and the chemical determination of disulfiram and blood acetaldehyde.
    Acta pharmacologica et toxicologica, 1957, Volume: 13, Issue:3

    Topics: Acetaldehyde; Alcoholic Intoxication; Disulfiram; Humans

1957
[Studies on the acetaldehyde concentration of blood in alcohol intoxication].
    Nihon hoigaku zasshi = The Japanese journal of legal medicine, 1963, Volume: 17

    Topics: Acetaldehyde; Alcoholic Intoxication; Blood Chemical Analysis; Humans

1963
[Death from acetaldehyde of metabolic origin during acute ethyl alcohol poisoning].
    La Riforma medica, 1955, Feb-19, Volume: 69, Issue:8

    Topics: Acetaldehyde; Alcoholic Intoxication; Child; Death; Ethanol; Humans; Infant; Poisoning

1955
[Variations in pyruvic acid and acetaldehyde blood level in alcoholic aggression].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1951, Volume: 145, Issue:21-22

    Topics: Acetaldehyde; Aggression; Alcoholic Intoxication; Humans; Pyruvates; Pyruvic Acid

1951
[Acetaldehyde concentration in acute ethanol-intoxicated patients addicted to alcohol].
    Przeglad lekarski, 2004, Volume: 61, Issue:4

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Biomarkers; Ethanol; Humans; Male; Middle A

2004
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
    Psychopharmacology, 2007, Volume: 189, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Body Temperature; Brain; Cent

2007
Maturation of whisky changes ethanol elimination kinetics and neural effects by increasing nonvolatile congeners.
    Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:1 Suppl

    Topics: Acetaldehyde; Acetates; Alcohol Dehydrogenase; Alcoholic Beverages; Alcoholic Intoxication; Animals;

2007
[Evaluation of ventilation disorders in alcohol addicted males].
    Przeglad lekarski, 2007, Volume: 64, Issue:4-5

    Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Bi

2007
Occurrence of trace indoles in mammals.
    Substance and alcohol actions/misuse, 1984, Volume: 5, Issue:5

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Brain; Carbolines; Formaldehyde; Humans;

1984
Assaying acetaldehyde in biological fluids.
    Lancet (London, England), 1981, Sep-05, Volume: 2, Issue:8245

    Topics: Acetaldehyde; Alcoholic Intoxication; Ethanol; Humans; Methods

1981
Survival after a blood acetaldehyde concentration of 1750 micrograms/dl.
    Lancet (London, England), 1983, Nov-12, Volume: 2, Issue:8359

    Topics: Acetaldehyde; Alcoholic Intoxication; Ethanol; Humans; Male; Middle Aged

1983
Cardiovascular effects of acetaldehyde accumulation after ethanol ingestion: their modification by beta-adrenergic blockade and alcohol dehydrogenase inhibition.
    Alcoholism, clinical and experimental research, 1983,Summer, Volume: 7, Issue:3

    Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcohol Oxidoreductases; Alcoholic Int

1983
Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1

    Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohol

1983
Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls.
    European journal of clinical investigation, 1984, Volume: 14, Issue:4

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Ethanol; Humans; Kinetics; Lactates; Lactic

1984
Time course of breath acetaldehyde concentrations during intravenous infusions of ethanol in healthy men.
    Drug and alcohol dependence, 1984, Volume: 14, Issue:2

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Breath Tests; Chromatography, Gas; Ethanol; Humans; Mal

1984
Interaction between acetaldehyde and sulfhydryl compounds in human blood during ethanol intoxication.
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1984, Volume: 19, Issue:1

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Drug Interactions; Humans; Sulfhydryl Compounds

1984
Human blood acetaldehyde concentration during ethanol oxidation (update 1982).
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases;

1983
Metabolic factors and preference for ethanol.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1

    Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Intoxication; Aldehyde Dehydrogenase; Aldehyde Oxidoreduct

1983
Effect of ethanol on hepatic secretory proteins.
    Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism, 1984, Volume: 2

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Blood Proteins; Ethanol; Glycoproteins; H

1984
[Permeability of the blood-brain barrier to 3H-GABA during alcoholic intoxication].
    Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 94, Issue:9

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Blood-Brain Barrier; Brain; Caudate Nucleus; Cerebral

1982
Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein.
    Experientia, 1981, Volume: 37, Issue:9

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Blood-Brain Barrier; Ethanol; Fluorescein; Fluorescei

1981
Ethanol and simulated high altitude. A study of three mouse strains.
    Archives of toxicology, 1982, Volume: 50, Issue:1

    Topics: Acetaldehyde; Alcoholic Intoxication; Altitude; Animals; Atmospheric Pressure; Behavior, Animal; Eth

1982
Biological markers: metabolism and acute reactions to alcohol in sons of alcoholics.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13 Suppl 1

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Ethanol; Humans; Male; Muscle Contraction; Prospec

1980
Difficulties in measuring human blood acetaldehyde concentrations during ethanol intoxication.
    Advances in experimental medicine and biology, 1980, Volume: 126

    Topics: Acetaldehyde; Alcoholic Intoxication; Blood Proteins; Blood Specimen Collection; Ethanol; Humans; Ki

1980
Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods.
    Advances in experimental medicine and biology, 1980, Volume: 132

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Brain Chemistry; Breath Tests; Humans; Male

1980
The acute effects of ethanol and acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1995, Volume: 30, Issue:2

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Contra

1995
Macrophages are a major source of acetaldehyde in circulating acetaldehyde-albumin complexes formed after exposure of mice to ethanol.
    Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:6

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Clodronic Acid; Female; Macrophages; Mice; Mice, Inbr

1994
Occurrence of blood acetaldehyde in women during ethanol intoxication: preliminary findings.
    Alcoholism, clinical and experimental research, 1993, Volume: 17, Issue:6

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Ethanol; Female; Humans; Sex Factors

1993
[Concentrations of ethanol and ethanol metabolites and symptoms of acute alcohol-intoxicated patients].
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1994, Volume: 29, Issue:1

    Topics: Acetaldehyde; Acetates; Acetone; Adult; Alcoholic Intoxication; Ethanol; Humans; Male; Middle Aged

1994
Problems involved in the determination of endogenous acetaldehyde in human blood.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1993, Volume: 28, Issue:5

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Chromatography, Gas; Erythrocytes; Et

1993
Influence of pyruvate, threonine and phosphoethanolamine on activities of some acetaldehyde-producing enzymes.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1993, Volume: 28, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Carbon-Oxygen Lyases; Ethanol; Ethanolamines; Glycine

1993
Pharmacodynamic response to Ro15-4513 in ethanol intoxicated dogs.
    Drug metabolism and drug interactions, 1996, Volume: 13, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Biotransformation; Blood Pre

1996
Effects of tea (Camellia sinensis) chemical compounds on ethanol metabolism in ICR mice.
    Bioscience, biotechnology, and biochemistry, 1996, Volume: 60, Issue:9

    Topics: Acetaldehyde; Acetates; Acetone; Administration, Oral; Alcoholic Intoxication; Animals; Caffeine; Ca

1996
Transglutaminase activity in rat brain after ethanol exposure.
    Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:7

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Brain; Dose-Response Relationship, Drug;

1997
[Effect of liver hydrolysate on ethanol- and acetaldehyde-induced deficiencies].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 111, Issue:2

    Topics: Acetaldehyde; Alanine Transaminase; Alcoholic Intoxication; Animals; Aspartate Aminotransferases; Ca

1998
Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute or chronic alcohol abuse: in vivo and in vitro studies.
    Italian journal of gastroenterology and hepatology, 1997, Volume: 29, Issue:2

    Topics: Acetaldehyde; Acute Disease; Adult; Alcoholic Intoxication; Alcoholism; Chronic Disease; Erythrocyte

1997
Fatal acute alcohol intoxication in an ALDH2 heterozygote: a case report.
    Forensic science international, 2000, Aug-14, Volume: 112, Issue:2-3

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitocho

2000
Electroencephalogram spectral characteristics after alcohol ingestion in Japanese men with aldehyde dehydrogenase-2 genetic variations: comparison with peripheral changes.
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:7

    Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Aldehyde Dehydrogenase; Aldehyde Dehy

2001
Concentration of ethanol and other volatile compounds in the blood of acutely poisoned alcoholics.
    Alcohol (Fayetteville, N.Y.), 2002, Volume: 26, Issue:1

    Topics: 1-Propanol; 2-Propanol; Acetaldehyde; Acetone; Adolescent; Adult; Aged; Alcoholic Intoxication; Alco

2002
[Suppression by ascorbic acid of neuromuscular fatigue due to sound-alcohol synergy].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1978, Sep-11, Volume: 287, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Ascorbic Acid; Fatigue; Humans; Inactivation, Metabol

1978
Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption.
    Science (New York, N.Y.), 1975, Aug-29, Volume: 189, Issue:4204

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Female; Glutamate Dehydrogenase; Humans; In Vitro Tec

1975
The acute toxicity of ethanol: dosage and kinetic nomograms.
    Veterinary and human toxicology, 1979, Volume: 21, Issue:4

    Topics: Acetaldehyde; Adolescent; Alcoholic Intoxication; Dose-Response Relationship, Drug; Ethanol; Female;

1979
Acetaldehyde in cerebrospinal fluid: its near-absence in ethanol-intoxicated alcoholics.
    Medical biology, 1979, Volume: 57, Issue:4

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Humans; Male; Middle Aged

1979
The cerebral oxidative metabolic response to acute ethanol administration in rats and cats.
    Neuropharmacology, 1977, Volume: 16, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Brain; Cats; Chlorpromazine; Cytochromes; Dose-Respon

1977
A possible protective role for sulphydryl compounds in acute alcoholic liver injury.
    Biochemical pharmacology, 1977, Aug-15, Volume: 26, Issue:16

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dos

1977
The presence of an aldehyde dehydrogenase inhibitor in animal diets and its effects on the experimental results in alcohol studies.
    The British journal of nutrition, 1978, Volume: 39, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Oxidoreductases; Amines; Animals; Cyanides; Diet; Eth

1978
Evidence against a role of acetaldehyde in electroencephalographic signs of ethanol-induced intoxication.
    Science (New York, N.Y.), 1979, Jan-19, Volume: 203, Issue:4377

    Topics: Acetaldehyde; Action Potentials; Alcoholic Intoxication; Animals; Brain; Dose-Response Relationship,

1979
A mechanism for decreased resistance to infection by gram-negative organisms during acute alcoholic intoxication.
    The Journal of laboratory and clinical medicine, 1975, Volume: 86, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Bacteria; Bacterial Infections; Blood Bac

1975
The effect of pargyline and other monoamine oxidase inhibitors on blood acetaldehyde levels in ethanol-intoxicated mice.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Oxidoreductases; Animals; Ethanol; Humans; Kinetics;

1976
Alcohol as a euphoriant drug: searching for a neurochemical basis.
    Annals of the New York Academy of Sciences, 1976, Volume: 273

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Brain; Catecholamines; Dopamine beta-Hydroxylase; Ethan

1976
Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication.
    Life sciences, 1975, Feb-15, Volume: 16, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Alkaloids; Animals; Brain; Brain Stem; Caudate Nucleus; Dopami

1975
Enzymatic production of acetaldehyde from ethanol in rat brain tissue.
    Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:5

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Animals; Brain; Catalase; Chromatograph

1992
Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers.
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1991, Volume: 26, Issue:6

    Topics: Acetaldehyde; Acetates; Acetone; Adult; Alcoholic Intoxication; Ethanol; Humans; Male

1991
Volatile compounds detected in blood of drunk drivers by headspace/capillary gas chromatography/ion trap mass spectrometry.
    Biological mass spectrometry, 1991, Volume: 20, Issue:11

    Topics: 1-Propanol; Acetaldehyde; Acetates; Acetone; Alcoholic Intoxication; Automobile Driving; Butanols; B

1991
Degrees of alcohol intoxication in 117 hospitalized cases.
    Journal of studies on alcohol, 1991, Volume: 52, Issue:5

    Topics: Acetaldehyde; Adult; Aged; Alcoholic Intoxication; Alcoholism; Ethanol; Flushing; Hospitalization; H

1991
In vivo accelerated acetaldehyde metabolism using acetaldehyde dehydrogenase-loaded erythrocytes.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1990, Volume: 25, Issue:6

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Oxidoreductases; Animals; Blood Transfusion; Erythroc

1990
Hemoglobin-acetaldehyde adducts in human volunteers following acute ethanol ingestion.
    Alcoholism, clinical and experimental research, 1990, Volume: 14, Issue:6

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Enzyme-Linked Immunosorbent Assay; Female; Flushing; He

1990
Effects of amino acids on acute alcohol intoxication in mice--concentrations of ethanol, acetaldehyde, acetate and acetone in blood and tissues.
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1990, Volume: 25, Issue:5

    Topics: Acetaldehyde; Acetates; Acetone; Alanine; Alcoholic Intoxication; Amino Acids; Animals; Cysteine; Et

1990
[New methods of pharmacokinetic evaluation of alcohol and its metabolites in female and male probands].
    Blutalkohol, 1990, Volume: 27, Issue:1

    Topics: Acetaldehyde; Acetates; Adult; Alcoholic Intoxication; Ethanol; Female; Humans; Male; Metabolic Clea

1990
Effects of acute ethanol intoxication on aldehyde dehydrogenase in mouse liver.
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1990, Volume: 25, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Ethanol; Liver; Male; Metabol

1990
Characterization of the increased binding of acetaldehyde to red blood cells in alcoholics.
    Alcoholism, clinical and experimental research, 1989, Volume: 13, Issue:5

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Binding Sites; Binding, Competitive; Erythrocytes;

1989
Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication.
    Journal of applied toxicology : JAT, 1989, Volume: 9, Issue:3

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; In Vitro Techniques; Lipid Peroxidation; Male; Malond

1989
[Biochemical mechanisms of cell lesions in alcoholism].
    La Revue du praticien, 1989, Sep-21, Volume: 39, Issue:21

    Topics: Acetaldehyde; Acetates; Alcoholic Intoxication; Alcoholism; Ethanol; Free Radicals; Humans; Microsom

1989
Changes in the blood of Wistar rats in acute poisoning with ethanol and acetaldehyde.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1987, Volume: 87, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Erythrocyte Volume; Erythrocytes; Hematocrit; Hemoglo

1987
Experimental studies on the mechanism of ethanol formation in corpses.
    Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1988, Volume: 101, Issue:1

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Blood Glucose; Cause of Death; Ethanol;

1988
Platelet function during acetaldehyde intoxication in healthy male volunteers.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1987, Volume: 1

    Topics: 6-Ketoprostaglandin F1 alpha; Acetaldehyde; Adult; Alcoholic Intoxication; Blood Platelets; Ethanol;

1987
Serotonin condensation product 5-hydroxymethtryptoline: evidence for in vivo formation from acetaldehyde during intoxication using deuterium labelled ethanol.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1987, Volume: 1

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Carbolines; Ethanol; Gas Chromatography-Mass Spectrom

1987
Effect of acetaldehyde on rat platelet aggregation in vivo and in vitro.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1987, Volume: 187, Issue:1

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Blood Coagulation; Male; Platelet Aggregation; Rats;

1987
[Influence of acute intake of alcoholic beverages on the cardiovascular system: clinical, electrocardiographic and laboratory observations].
    Arquivos brasileiros de cardiologia, 1986, Volume: 47, Issue:1

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Arrhythmias, Cardiac; Electrocardiography; Ethanol; Hea

1986
Acute and chronic effect of ethanol on hepatic albumin synthesis in rat liver in vitro.
    Research communications in chemical pathology and pharmacology, 1986, Volume: 53, Issue:2

    Topics: Acetaldehyde; Albumins; Alcoholic Intoxication; Alcoholism; Animals; Chromatography, DEAE-Cellulose;

1986
Haematological abnormalities in mice continuously exposed to ethanol vapour.
    British journal of experimental pathology, 1986, Volume: 67, Issue:6

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Bone Marrow; Dose-Response Relationship, Drug; Ethano

1986
Release of acid proteolytic activity from lysosomes and degradation of protein in organs of rats intoxicated with ethanol and acetaldehyde.
    Acta biochimica Polonica, 1985, Volume: 32, Issue:3

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Kidney; Liver; Lung; Lysosomes; Octoxynol; Peptide Hy

1985
Suppression of acetaldehyde accumulation by 4-methylpyrazole in alcohol-hypersensitive Japanese.
    Japanese journal of pharmacology, 1985, Volume: 38, Issue:1

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Flushing; Fomepizole; Heart; Heart Rate; Humans; Male;

1985
Gastric erosions caused by home-brewed lager.
    Lancet (London, England), 1971, Oct-09, Volume: 2, Issue:7728

    Topics: Acetaldehyde; Acetates; Acetobacter; Adult; Alcoholic Intoxication; Alcohols; Animals; Beer; Chromat

1971
Ethanol and acetaldehyde effects on metabolism and binding of biogenic amines.
    Quarterly journal of studies on alcohol, 1974, Volume: 35, Issue:1

    Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Animals; Biogenic Amines; Brain; Brai

1974
Pyrogallol potentiates acetaldehyde blood levels during ethanol oxidation in rats.
    Chemico-biological interactions, 1974, Volume: 8, Issue:2

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Chromatography, Gas; Ethanol; Humans; Male; Pyrogallo

1974
[Acetaldehyde and alcoholism. The pharmacogenesis of the teturam-alcohol reaction and its control by way of binding acetaldehyde with sodium metabisulfite].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:2

    Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Animals; Disulfiram; Humans; Mice; Sulfites

1973
Adsorption of whisky congeners by activated charcoal. Chemical and clinical studies related to hangover.
    Southwestern medicine, 1971, Volume: 52, Issue:9

    Topics: Acetaldehyde; Acetates; Adsorption; Adult; Alcoholic Intoxication; Alcohols; Animals; Charcoal; Etha

1971
Blood methanol concentrations during experimentally induced ethanol intoxication in alcoholics.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 179, Issue:2

    Topics: Acetaldehyde; Acetone; Adult; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Chromatograph

1971
Studies on the antidotal action of drugs. 1. Vitamin C and its antidotal effect against alcoholic and nicotine poisoning.
    The Journal of Nihon University School of Dentistry, 1969, Volume: 11, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Antidotes; Ascorbic Acid; Cysteine; Drug Synergism; H

1969
Alcohol oxidation in rate inhibited by pyrazole, oximes, and amides.
    Science (New York, N.Y.), 1970, Jul-17, Volume: 169, Issue:3942

    Topics: 1-Propanol; Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohols; Amides; Animals

1970
Effects of alcoholic beverages and congeners on psychomotor skills in old and young subjects.
    Quarterly journal of studies on alcohol, 1970, Volume: 5

    Topics: Acetaldehyde; Acetates; Adult; Aged; Aging; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; F

1970
Depression of delta-aminolaevulic acid dehydrase activity by ethanol in man and rat.
    Clinical science, 1971, Volume: 40, Issue:1

    Topics: Acetaldehyde; Acetates; Adolescent; Adult; Aged; Alcoholic Intoxication; Amino Acids; Animals; Coenz

1971
Analytical research of acute alcoholic intoxication.
    Nihon hoigaku zasshi = The Japanese journal of legal medicine, 1967, Volume: 21, Issue:3

    Topics: Acetaldehyde; Alcoholic Intoxication; Alcohols; Animals; Chromatography, Gas; Electromyography; Huma

1967
Effect of congeners in alcoholic beverages on the incidence of nystagmus.
    Quarterly journal of studies on alcohol, 1966, Volume: 27, Issue:2

    Topics: 1-Propanol; Acetaldehyde; Acetates; Adult; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; Et

1966