acetaldehyde has been researched along with Alcoholic Intoxication in 117 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Alcoholic Intoxication: An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The interaction between effects of ethanol ingestion and those of infrasound on neuro-muscular fatigue in the animal is abolished by ascorbic acid." | 7.66 | [Suppression by ascorbic acid of neuromuscular fatigue due to sound-alcohol synergy]. ( Busnel, RG; Lehmann, AG, 1978) |
| " Direct administration of acetate increased nociceptive behaviors suggesting that acetate, not acetaldehyde, accumulation results in hangover-like hypersensitivity in our model." | 3.76 | Acetate causes alcohol hangover headache in rats. ( Hoek, JB; Maxwell, CR; Oshinsky, ML; Silberstein, SD; Spangenberg, RJ, 2010) |
| "The correlation among degrees of alcohol intoxication, facial flushing, blood alcohol concentration (BAC) and blood acetaldehyde level was studied in 117 male alcoholic patients who underwent various tests to assess alcohol influence." | 3.68 | Degrees of alcohol intoxication in 117 hospitalized cases. ( Adachi, J; Fukunaga, T; Imamichi, H; Mizoi, Y; Ogawa, Y; Ueno, Y, 1991) |
| "Alcohol-sensitive Japanese subjects with facial flushing and an increase in heart rate during ethanol intoxication exhibited marked individual variation in accumulation of acetaldehyde." | 3.67 | Suppression of acetaldehyde accumulation by 4-methylpyrazole in alcohol-hypersensitive Japanese. ( Inoue, K; Kera, Y; Kiriyama, T; Komura, S, 1985) |
| "The interaction between effects of ethanol ingestion and those of infrasound on neuro-muscular fatigue in the animal is abolished by ascorbic acid." | 3.66 | [Suppression by ascorbic acid of neuromuscular fatigue due to sound-alcohol synergy]. ( Busnel, RG; Lehmann, AG, 1978) |
| "A hereditary element to alcohol dependence has been suggested by several adoption and twin studies, but the many contradictions between research results emphasise that any genetic contribution is overshadowed by socio-cultural factors." | 2.37 | Psychiatric advances in the understanding and treatment of alcohol dependence. ( Madden, JS, 1984) |
| " About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes." | 1.56 | Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity. ( Barrientos, FL; Cervantes, PR; Chen, CH; Ferreira, JCB; Ferreira, ND; Hsu, JH; Joshi, AU; Li, SJ; Maclean, R; Martinez, DD; Mochly-Rosen, D; Quintanares, GHR; Stevens, MC, 2020) |
| "The mechanism of veisalgia cephalgia or hangover headache is unknown." | 1.36 | Acetate causes alcohol hangover headache in rats. ( Hoek, JB; Maxwell, CR; Oshinsky, ML; Silberstein, SD; Spangenberg, RJ, 2010) |
| "It also prolonged drunkenness by enhancing the neurodepressive effects of ethanol, due to increases in the amount of nonvolatile congeners." | 1.34 | Maturation of whisky changes ethanol elimination kinetics and neural effects by increasing nonvolatile congeners. ( Haseba, T; Mashimo, K; Ohno, Y; Sato, S; Sugimoto, J, 2007) |
| "Alcohol addiction was diagnosed according to ICD-10 criteria." | 1.32 | [Acetaldehyde concentration in acute ethanol-intoxicated patients addicted to alcohol]. ( Gawlikowski, T; Gomółka, E; Król, A; Piekoszewski, W, 2004) |
| "Acetaldehyde treatment alone caused no significant inhibition of protein synthesis." | 1.29 | The acute effects of ethanol and acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum. ( Marway, JS; Preedy, VR, 1995) |
| "Facial flushing was recognized in 75% of the subjects." | 1.28 | Degrees of alcohol intoxication in 117 hospitalized cases. ( Adachi, J; Fukunaga, T; Imamichi, H; Mizoi, Y; Ogawa, Y; Ueno, Y, 1991) |
| " Therefore, a new pharmacokinetic model takes into account Michaelis-Menten-elimination kinetics of ethanol as well as kinetics of acetaldehyde and acetate, which are defined by first order processes." | 1.28 | [New methods of pharmacokinetic evaluation of alcohol and its metabolites in female and male probands]. ( Bitsch, I; Kohlenberg-Müller, K, 1990) |
| "When acetaldehyde was added first, ethanol production was inhibited the next day, but on and after day 2, the quantity of ethanol was more than that in the control material." | 1.27 | Experimental studies on the mechanism of ethanol formation in corpses. ( Hashimoto, Y; Moriya, F; Nanikawa, R, 1988) |
| "Acetaldehyde was found in circulation following ethanol intoxication or was present after direct i." | 1.27 | Effect of acetaldehyde on rat platelet aggregation in vivo and in vitro. ( Bengmark, S; Zoucas, E, 1987) |
| "Blood AcH in occasional or chronic alcohol abusers were generally low (< 10 microM), elevated AcH levels being observed only in association with clinical abnormalities." | 1.26 | Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods. ( Hillbom, M; Lindros, KO; Salaspuro, M; Stowell, A, 1980) |
| " We present 2 illustrative cases, discuss the acute toxicity of ethanol, and present 2 simple calculating charts for dosage and kinetics." | 1.26 | The acute toxicity of ethanol: dosage and kinetic nomograms. ( David, DJ; Spyker, DA, 1979) |
| " At low infusion dosage when the EEG was unaffected, concentrations of acetaldehyde in the blood were equal to or greater than those which occur during intoxication." | 1.26 | Evidence against a role of acetaldehyde in electroencephalographic signs of ethanol-induced intoxication. ( Klemm, WR; Mikeska, JA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (56.41) | 18.7374 |
| 1990's | 25 (21.37) | 18.2507 |
| 2000's | 14 (11.97) | 29.6817 |
| 2010's | 9 (7.69) | 24.3611 |
| 2020's | 3 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Li, S | 2 |
| Zheng, Y | 1 |
| Xiao, L | 1 |
| Lan, S | 1 |
| Xiang, J | 1 |
| Liao, L | 1 |
| Lin, Y | 1 |
| Ye, Y | 1 |
| Kim, KJ | 1 |
| Park, SY | 1 |
| Park, TG | 1 |
| Park, HJ | 1 |
| Kim, YJ | 1 |
| Kim, EJ | 1 |
| Shin, W | 1 |
| Kim, A | 1 |
| Yoo, H | 1 |
| Kweon, M | 1 |
| Jang, J | 1 |
| Choi, SY | 1 |
| Kim, JY | 1 |
| Chen, CH | 1 |
| Ferreira, JCB | 1 |
| Joshi, AU | 1 |
| Stevens, MC | 1 |
| Li, SJ | 1 |
| Hsu, JH | 1 |
| Maclean, R | 1 |
| Ferreira, ND | 1 |
| Cervantes, PR | 1 |
| Martinez, DD | 1 |
| Barrientos, FL | 1 |
| Quintanares, GHR | 1 |
| Mochly-Rosen, D | 1 |
| Alexandrovich, YG | 1 |
| Kosenko, EA | 1 |
| Sinauridze, EI | 1 |
| Obydennyi, SI | 1 |
| Kireev, II | 1 |
| Ataullakhanov, FI | 1 |
| Kaminsky, YG | 1 |
| Lee, MH | 1 |
| Kwak, JH | 1 |
| Jeon, G | 1 |
| Lee, JW | 1 |
| Seo, JH | 1 |
| Lee, HS | 2 |
| Lee, JH | 1 |
| Bébarová, M | 1 |
| Matejovič, P | 1 |
| Šimurdová, M | 1 |
| Šimurda, J | 1 |
| Zhao, Y | 1 |
| Sun, J | 1 |
| Hu, J | 1 |
| Bo, N | 1 |
| Yu, B | 1 |
| Zhang, YJ | 1 |
| Wang, F | 1 |
| Zhou, Y | 1 |
| Li, Y | 1 |
| Zhou, T | 1 |
| Zheng, J | 1 |
| Zhang, JJ | 1 |
| Xu, DP | 1 |
| Li, HB | 1 |
| Yokoyama, A | 1 |
| Kamada, Y | 1 |
| Imazeki, H | 1 |
| Hayashi, E | 1 |
| Murata, S | 1 |
| Kinoshita, K | 1 |
| Yokoyama, T | 1 |
| Kitagawa, Y | 1 |
| Venkataranganna, MV | 1 |
| Gopumadhavan, S | 1 |
| Sundaram, R | 1 |
| Peer, G | 1 |
| Mitra, SK | 1 |
| Kanteres, F | 1 |
| Lachenmeier, DW | 1 |
| Rehm, J | 1 |
| Song, J | 1 |
| Kim, TM | 1 |
| Joo, SS | 1 |
| Park, D | 1 |
| Jeon, JH | 1 |
| Shin, S | 1 |
| Park, HK | 1 |
| Lee, WK | 1 |
| Ly, SY | 1 |
| Kim, MR | 1 |
| Lee, DI | 1 |
| Kim, YB | 1 |
| Min, JA | 1 |
| Lee, K | 1 |
| Ki, DJ | 1 |
| Maxwell, CR | 1 |
| Spangenberg, RJ | 1 |
| Hoek, JB | 1 |
| Silberstein, SD | 1 |
| Oshinsky, ML | 1 |
| Amireche, N | 1 |
| Petit, JS | 1 |
| Bankole, E | 1 |
| Fournet-Fayard, A | 1 |
| Appriou, M | 1 |
| Leon, A | 1 |
| Smith, D | 1 |
| Wang, T | 1 |
| Spanĕl, P | 1 |
| ALHA, AR | 1 |
| HJELT, E | 1 |
| TAMMINEN, V | 1 |
| MIZOI, Y | 4 |
| OHGA, N | 1 |
| ROMANO, C | 1 |
| LECOQ, R | 1 |
| Gawlikowski, T | 1 |
| Piekoszewski, W | 2 |
| Gomółka, E | 1 |
| Król, A | 1 |
| Izco, M | 1 |
| Orio, L | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
| Haseba, T | 2 |
| Mashimo, K | 1 |
| Sugimoto, J | 1 |
| Sato, S | 1 |
| Ohno, Y | 1 |
| Chmiest, W | 1 |
| Targosz, D | 1 |
| Gawlikowsk, T | 1 |
| McGregor, NR | 1 |
| Beck, O | 2 |
| Thomas, M | 1 |
| Lim, CK | 1 |
| Peters, TJ | 1 |
| Kobayashi, M | 1 |
| Watanabe, A | 1 |
| Hobara, N | 1 |
| Nakatsukasa, H | 1 |
| Nagashima, H | 1 |
| Fujimoto, A | 1 |
| Kupari, M | 1 |
| Lindros, K | 1 |
| Hillbom, M | 3 |
| Heikkilä, J | 1 |
| Ylikahri, R | 1 |
| Tatsuno, Y | 1 |
| Adachi, J | 2 |
| Kogame, M | 1 |
| Fukunaga, T | 9 |
| Fujiwara, S | 1 |
| Hishida, S | 1 |
| Ijiri, I | 1 |
| Madden, JS | 1 |
| Nuutinen, HU | 1 |
| Salaspuro, MP | 1 |
| Valle, M | 1 |
| Lindros, KO | 3 |
| Jones, AW | 3 |
| Skagerberg, S | 1 |
| Borg, S | 1 |
| Anggård, E | 1 |
| Inoue, K | 2 |
| Fukunaga, M | 1 |
| Ohbora, Y | 1 |
| Kiriyama, T | 2 |
| Komura, S | 3 |
| Eriksson, CJ | 10 |
| Sadovnik, MN | 1 |
| Satanovskaya, VI | 1 |
| Selevich, MI | 1 |
| Buko, VU | 1 |
| Lelevich, VI | 1 |
| Lukashik, NK | 1 |
| Tuma, DJ | 1 |
| Sorrell, MF | 1 |
| Borisenko, SA | 1 |
| Tolmacheva, NS | 1 |
| Burov, IuV | 1 |
| Blinkova, NF | 1 |
| Hillbom, ME | 3 |
| Tervo, TM | 1 |
| Messiha, FS | 1 |
| Schuckit, MA | 1 |
| Sovijärvi, AR | 1 |
| Stowell, A | 1 |
| Salaspuro, M | 1 |
| Marway, JS | 1 |
| Preedy, VR | 1 |
| Wickramasinghe, SN | 2 |
| Mawas, F | 1 |
| Hasan, R | 1 |
| Brown, IN | 1 |
| Goldin, RD | 1 |
| Sillanaukee, P | 2 |
| Kitazawa, M | 1 |
| Tsukamoto, S | 4 |
| Kanegae, T | 4 |
| Tie, J | 1 |
| Kaneko, Y | 1 |
| Shiratori, R | 1 |
| Oshida, S | 1 |
| Gerashchenko, D | 1 |
| Gorenshtein, B | 1 |
| Pyzhik, T | 1 |
| Ostrovsky, Yu | 1 |
| Sarkola, T | 1 |
| Lindholm, H | 1 |
| Ahola, L | 1 |
| Whitmire, D | 1 |
| Cornelius, LM | 1 |
| Whitmire, PS | 1 |
| Kakuda, T | 1 |
| Sakane, I | 1 |
| Takihara, T | 1 |
| Nagoya, T | 3 |
| Sessa, A | 1 |
| Tunici, P | 1 |
| Rabellotti, E | 1 |
| Perin, A | 1 |
| Washizuka, M | 1 |
| Hiraga, Y | 1 |
| Furuichi, H | 1 |
| Izumi, J | 1 |
| Yoshinaga, K | 1 |
| Abe, T | 1 |
| Tanaka, Y | 1 |
| Tamaki, H | 1 |
| Loguercio, C | 1 |
| Clot, P | 1 |
| Albano, E | 1 |
| Argenzio, F | 1 |
| Grella, A | 1 |
| De Girolamo, V | 1 |
| Delle Cave, M | 1 |
| Del Vecchio Bianco, C | 1 |
| Nardi, G | 1 |
| Laposata, M | 1 |
| Yamamoto, H | 1 |
| Tanegashima, A | 1 |
| Hosoe, H | 1 |
| Nishimura, FT | 1 |
| Nishijo, H | 1 |
| Ono, T | 1 |
| Kajiura And, H | 1 |
| Yokomukai, Y | 1 |
| Sharpe, PC | 1 |
| Zuba, D | 1 |
| Pach, J | 1 |
| Winnik, L | 1 |
| Parczewski, A | 1 |
| Busnel, RG | 1 |
| Lehmann, AG | 1 |
| Bing, RJ | 1 |
| Hasumura, Y | 2 |
| Teschke, R | 2 |
| Lieber, CS | 3 |
| Majchrowicz, E | 3 |
| Hunt, WA | 1 |
| Lahti, RA | 2 |
| Ogata, M | 1 |
| Karoum, F | 1 |
| DeCarli, LM | 1 |
| Feinman, L | 1 |
| Korsten, M | 1 |
| Matsuzaki, S | 1 |
| David, DJ | 1 |
| Spyker, DA | 1 |
| LaManna, JC | 1 |
| Younts, BW | 1 |
| Rosenthal, M | 1 |
| Macdonald, CM | 1 |
| Dow, J | 1 |
| Moore, MR | 2 |
| Tottmar, O | 1 |
| Marchner, H | 1 |
| Karlsson, N | 1 |
| Mikeska, JA | 1 |
| Klemm, WR | 1 |
| Marr, JJ | 1 |
| Spilberg, I | 1 |
| Dembiec, D | 1 |
| MacNamee, D | 1 |
| Cohen, G | 1 |
| Ewing, JA | 1 |
| Rouse, BA | 1 |
| Mueller, RA | 1 |
| Mills, KC | 1 |
| Collins, MA | 2 |
| Bigdeli, MG | 2 |
| Gill, K | 1 |
| Menez, JF | 1 |
| Lucas, D | 1 |
| Deitrich, RA | 1 |
| Skrzydlewska, E | 2 |
| Worowski, K | 2 |
| Roszkowska-Jakimiec, W | 1 |
| Saito, M | 1 |
| Shimamura, M | 2 |
| Tainaka, H | 1 |
| Kawaguchi, M | 1 |
| Schuberth, J | 1 |
| Ogawa, Y | 1 |
| Ueno, Y | 1 |
| Imamichi, H | 1 |
| Magnani, M | 1 |
| Laguerre, M | 1 |
| Rossi, L | 1 |
| Bianchi, M | 1 |
| Ninfali, P | 1 |
| Mangani, F | 1 |
| Ropars, C | 1 |
| Niemelä, O | 1 |
| Israel, Y | 1 |
| Mieda, Y | 1 |
| Nomura, M | 1 |
| Hojo, K | 1 |
| Okubo, H | 1 |
| Kohlenberg-Müller, K | 1 |
| Bitsch, I | 1 |
| Tomita, Y | 1 |
| Kurosu, M | 1 |
| Watanabe, T | 1 |
| Hernández-Muñoz, R | 1 |
| Baraona, E | 1 |
| Blacksberg, I | 1 |
| Uysal, M | 1 |
| Ozdemirler, G | 1 |
| Kutalp, G | 1 |
| Oz, H | 1 |
| Nordmann, R | 1 |
| Kukiełka, E | 1 |
| Nanikawa, R | 1 |
| Moriya, F | 1 |
| Hashimoto, Y | 1 |
| Neiman, J | 1 |
| Benthin, G | 1 |
| Löwbeer, C | 1 |
| Tyler, A | 1 |
| Faull, K | 1 |
| Zoucas, E | 1 |
| Bengmark, S | 1 |
| João, SR | 1 |
| Ohtake, H | 1 |
| Kato, S | 1 |
| Murawaki, Y | 1 |
| Kishimoto, Y | 1 |
| Wakushima, T | 1 |
| Hirayama, C | 1 |
| Malik, F | 1 |
| Skrzydlewski, Z | 1 |
| Kera, Y | 1 |
| O'Keane, M | 1 |
| Smith, S | 1 |
| Goldberg, A | 2 |
| Egaña, E | 1 |
| Rodrigo, R | 1 |
| Gordon, R | 1 |
| Rubenstein, JA | 1 |
| Ezrielev, GI | 1 |
| Ylikahri, RH | 1 |
| Huttunen, MO | 1 |
| Nikkilä, EA | 1 |
| Mendelson, JH | 2 |
| Damrau, F | 1 |
| Goldberg, AH | 1 |
| Tamura, T | 1 |
| Inoue, H | 1 |
| Iida, T | 1 |
| Ono, H | 1 |
| Lester, D | 1 |
| Benson, GD | 1 |
| Wilson, AS | 1 |
| Barboriak, JJ | 1 |
| Kass, WA | 1 |
| Beattie, AD | 1 |
| Thompson, GG | 1 |
| Ueda, M | 1 |
| Fukui, Y | 1 |
| Yamamoto, K | 1 |
| Kobayashi, T | 1 |
| Murphree, HB | 1 |
| Price, LM | 1 |
| Greenberg, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of β-nicotinamide Mononucleotide Intervention on Healthy Young Subjects With Acute Binge Drink: a Double-blinded, Randomized, Crossover Trial[NCT05882214] | 20 participants (Anticipated) | Interventional | 2023-12-31 | Recruiting | |||
| Evaluation of a Fixed Combination of Herbal Extracts to Prevent Symptoms Alcohol-induced Hangovers : A Randomized, Double Blind Placebo Controlled Crossover Study.[NCT04183842] | 40 participants (Actual) | Interventional | 2019-07-04 | Completed | |||
| A Phase IIa, Prospective, Randomized, Blinded, Intra-Subject Controlled, Single Dose, Dose Escalation Study of Antizol® for Mitigation of Acetaldehyde Related Toxicity in Human Subjects With Symptoms of Inborn Altered Ethanol Metabolism With Concomitant E[NCT00661141] | Phase 2 | 32 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | ng/mL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 2386 |
| Ethanol Followed by 1.0 mg/kg Antizol | 1358 |
| 3.0 mg/kg Antizol Followed by Ethanol | 5605 |
| Ethanol Followed by 3.0 mg/kg Antizol | 4680 |
| 5.0 mg/kg Antizol Followed by Ethanol | 8623 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | L/hr (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 6.70 |
| Ethanol Followed by 1.0 mg/kg Antizol | 8.23 |
| 3.0 mg/kg Antizol Followed by Ethanol | 3.15 |
| Ethanol Followed by 3.0 mg/kg Antizol | 2.99 |
| 5.0 mg/kg Antizol Followed by Ethanol | 2.35 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | Liters (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 26.3 |
| Ethanol Followed by 1.0 mg/kg Antizol | 24.7 |
| 3.0 mg/kg Antizol Followed by Ethanol | 24.4 |
| Ethanol Followed by 3.0 mg/kg Antizol | 24.9 |
| 5.0 mg/kg Antizol Followed by Ethanol | 24.7 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | ng*hr/mL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 13804 |
| Ethanol Followed by 1.0 mg/kg Antizol | 7409 |
| 3.0 mg/kg Antizol Followed by Ethanol | 44942 |
| Ethanol Followed by 3.0 mg/kg Antizol | 34310 |
| 5.0 mg/kg Antizol Followed by Ethanol | 109298 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | ng*hr/mL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 11035 |
| Ethanol Followed by 1.0 mg/kg Antizol | 7627 |
| 3.0 mg/kg Antizol Followed by Ethanol | 55452 |
| Ethanol Followed by 3.0 mg/kg Antizol | 57028 |
| 5.0 mg/kg Antizol Followed by Ethanol | 136871 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | (ng*hr/mL)/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 149 |
| Ethanol Followed by 1.0 mg/kg Antizol | 122 |
| 3.0 mg/kg Antizol Followed by Ethanol | 317 |
| Ethanol Followed by 3.0 mg/kg Antizol | 334 |
| 5.0 mg/kg Antizol Followed by Ethanol | 460 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | (ng*hr/mL)/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 223 |
| Ethanol Followed by 1.0 mg/kg Antizol | 103 |
| 3.0 mg/kg Antizol Followed by Ethanol | 231 |
| Ethanol Followed by 3.0 mg/kg Antizol | 204 |
| 5.0 mg/kg Antizol Followed by Ethanol | 378 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | (ng/mL)/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 38.3 |
| Ethanol Followed by 1.0 mg/kg Antizol | 18.9 |
| 3.0 mg/kg Antizol Followed by Ethanol | 27.6 |
| Ethanol Followed by 3.0 mg/kg Antizol | 28.0 |
| 5.0 mg/kg Antizol Followed by Ethanol | 30.2 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | hours (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 2.72 |
| Ethanol Followed by 1.0 mg/kg Antizol | 3.11 |
| 3.0 mg/kg Antizol Followed by Ethanol | 5.37 |
| Ethanol Followed by 3.0 mg/kg Antizol | 5.76 |
| 5.0 mg/kg Antizol Followed by Ethanol | 9.26 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | percentage (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 16.8 |
| Ethanol Followed by 1.0 mg/kg Antizol | 13.0 |
| 3.0 mg/kg Antizol Followed by Ethanol | 3.31 |
| Ethanol Followed by 3.0 mg/kg Antizol | 4.37 |
| 5.0 mg/kg Antizol Followed by Ethanol | 13.2 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | hours (Median) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 1.00 |
| Ethanol Followed by 1.0 mg/kg Antizol | 2.50 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.667 |
| Ethanol Followed by 3.0 mg/kg Antizol | 1.48 |
| 5.0 mg/kg Antizol Followed by Ethanol | 1.00 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | µM*hr (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 234 |
| Ethanol Followed by 1.0 mg/kg Antizol | 154 |
| 3.0 mg/kg Antizol Followed by Ethanol | 297 |
| Ethanol Followed by 3.0 mg/kg Antizol | 302 |
| 5.0 mg/kg Antizol Followed by Ethanol | 188 |
| Placebo Followed by Ethanol | 205 |
| Ethanol Followed by Placebo | 227 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | µM*hr (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 178 |
| Ethanol Followed by 1.0 mg/kg Antizol | 118 |
| 3.0 mg/kg Antizol Followed by Ethanol | 155 |
| Ethanol Followed by 3.0 mg/kg Antizol | 167 |
| 5.0 mg/kg Antizol Followed by Ethanol | 128 |
| Placebo Followed by Ethanol | 163 |
| Ethanol Followed by Placebo | 139 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | percentage (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 19.0 |
| Ethanol Followed by 1.0 mg/kg Antizol | 18.8 |
| 3.0 mg/kg Antizol Followed by Ethanol | 13.1 |
| Ethanol Followed by 3.0 mg/kg Antizol | 9.78 |
| 5.0 mg/kg Antizol Followed by Ethanol | 24.7 |
| Placebo Followed by Ethanol | 13.7 |
| Ethanol Followed by Placebo | 14.5 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | µM (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 59.6 |
| Ethanol Followed by 1.0 mg/kg Antizol | 37.6 |
| 3.0 mg/kg Antizol Followed by Ethanol | 50.9 |
| Ethanol Followed by 3.0 mg/kg Antizol | 55.9 |
| 5.0 mg/kg Antizol Followed by Ethanol | 40.0 |
| Placebo Followed by Ethanol | 60.3 |
| Ethanol Followed by Placebo | 42.7 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | µM*hr/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.00682 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.00432 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.00929 |
| Ethanol Followed by 3.0 mg/kg Antizol | 0.0105 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.00626 |
| Placebo Followed by Ethanol | 0.00616 |
| Ethanol Followed by Placebo | 0.00752 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | µM*hr/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.00547 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.00329 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.00470 |
| Ethanol Followed by 3.0 mg/kg Antizol | 0.00597 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.00439 |
| Placebo Followed by Ethanol | 0.00521 |
| Ethanol Followed by Placebo | 0.00455 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | µM/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.00181 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.00104 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.00157 |
| Ethanol Followed by 3.0 mg/kg Antizol | 0.00201 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.00138 |
| Placebo Followed by Ethanol | 0.00193 |
| Ethanol Followed by Placebo | 0.00141 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | hours (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 3.14 |
| Ethanol Followed by 1.0 mg/kg Antizol | 3.08 |
| 3.0 mg/kg Antizol Followed by Ethanol | 2.48 |
| Ethanol Followed by 3.0 mg/kg Antizol | 1.72 |
| 5.0 mg/kg Antizol Followed by Ethanol | 3.45 |
| Placebo Followed by Ethanol | 2.39 |
| Ethanol Followed by Placebo | 2.09 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | hours (Median) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.500 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.650 |
| 3.0 mg/kg Antizol Followed by Ethanol | 1.00 |
| Ethanol Followed by 3.0 mg/kg Antizol | 1.33 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.500 |
| Placebo Followed by Ethanol | 0.500 |
| Ethanol Followed by Placebo | 0.925 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | mg*hr/mL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 245 |
| Ethanol Followed by 1.0 mg/kg Antizol | 263 |
| 3.0 mg/kg Antizol Followed by Ethanol | 237 |
| Ethanol Followed by 3.0 mg/kg Antizol | 215 |
| 5.0 mg/kg Antizol Followed by Ethanol | 271 |
| Placebo Followed by Ethanol | 214 |
| Ethanol Followed by Placebo | 198 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | mg*hr/dL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 209 |
| Ethanol Followed by 1.0 mg/kg Antizol | 209 |
| 3.0 mg/kg Antizol Followed by Ethanol | 205 |
| Ethanol Followed by 3.0 mg/kg Antizol | 135 |
| 5.0 mg/kg Antizol Followed by Ethanol | 231 |
| Placebo Followed by Ethanol | 157 |
| Ethanol Followed by Placebo | 152 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | percentage (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 14.7 |
| Ethanol Followed by 1.0 mg/kg Antizol | 20.5 |
| 3.0 mg/kg Antizol Followed by Ethanol | 13.2 |
| Ethanol Followed by 3.0 mg/kg Antizol | 20.0 |
| 5.0 mg/kg Antizol Followed by Ethanol | 12.1 |
| Placebo Followed by Ethanol | 13.4 |
| Ethanol Followed by Placebo | 13.9 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | dL/hr (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 140 |
| Ethanol Followed by 1.0 mg/kg Antizol | 138 |
| 3.0 mg/kg Antizol Followed by Ethanol | 142 |
| Ethanol Followed by 3.0 mg/kg Antizol | 131 |
| 5.0 mg/kg Antizol Followed by Ethanol | 112 |
| Placebo Followed by Ethanol | 159 |
| Ethanol Followed by Placebo | 167 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | mg/dL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 62.7 |
| Ethanol Followed by 1.0 mg/kg Antizol | 70.3 |
| 3.0 mg/kg Antizol Followed by Ethanol | 80.5 |
| Ethanol Followed by 3.0 mg/kg Antizol | 43.3 |
| 5.0 mg/kg Antizol Followed by Ethanol | 74.9 |
| Placebo Followed by Ethanol | 59.3 |
| Ethanol Followed by Placebo | 55.1 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | (mg*hr/dL)/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.00760 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.00731 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.00705 |
| Ethanol Followed by 3.0 mg/kg Antizol | 0.00768 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.00917 |
| Placebo Followed by Ethanol | 0.00681 |
| Ethanol Followed by Placebo | 0.00617 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | (mg*hr/dL)/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.00648 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.00585 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.00613 |
| Ethanol Followed by 3.0 mg/kg Antizol | 0.00483 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.00791 |
| Placebo Followed by Ethanol | 0.00508 |
| Ethanol Followed by Placebo | 0.00476 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | (mg/dL)/mg (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 0.00195 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.00198 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.00243 |
| Ethanol Followed by 3.0 mg/kg Antizol | 0.00155 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.00261 |
| Placebo Followed by Ethanol | 0.00193 |
| Ethanol Followed by Placebo | 0.00175 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | hours (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 1.51 |
| Ethanol Followed by 1.0 mg/kg Antizol | 1.95 |
| 3.0 mg/kg Antizol Followed by Ethanol | 1.43 |
| Ethanol Followed by 3.0 mg/kg Antizol | 1.78 |
| 5.0 mg/kg Antizol Followed by Ethanol | 1.67 |
| Placebo Followed by Ethanol | 1.45 |
| Ethanol Followed by Placebo | 1.32 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | hours (Median) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 1.50 |
| Ethanol Followed by 1.0 mg/kg Antizol | 0.833 |
| 3.0 mg/kg Antizol Followed by Ethanol | 0.500 |
| Ethanol Followed by 3.0 mg/kg Antizol | 1.42 |
| 5.0 mg/kg Antizol Followed by Ethanol | 0.500 |
| Placebo Followed by Ethanol | 0.500 |
| Ethanol Followed by Placebo | 1.01 |
(NCT00661141)
Timeframe: Days 1 and 2: prior to administration of 1st treatment (ethanol or study drug); 10, 20, and 30 min prior to administration of second treatment (study drug or ethanol); 40, 50, 60 min and 2, 3, 4, 5, 6, and 8 hr post administration of 1st treatment
| Intervention | dL (Mean) |
|---|---|
| 1.0 mg/kg Antizol Followed by Ethanol | 297 |
| Ethanol Followed by 1.0 mg/kg Antizol | 387 |
| 3.0 mg/kg Antizol Followed by Ethanol | 295 |
| Ethanol Followed by 3.0 mg/kg Antizol | 330 |
| 5.0 mg/kg Antizol Followed by Ethanol | 242 |
| Placebo Followed by Ethanol | 287 |
| Ethanol Followed by Placebo | 321 |
AEs were collected to evaluate the safety and tolerability of oral Antizol with concomitant ethanol administration in particitpants with symptoms of acetaldehyde toxicity associated with altered ethanol metabolism. AE: any untoward medical event that occurs following the first administration of study medication until the study participant's last study visit, whether or not the event is considered drug related. SAE: an event that meets any of the following criteria: results in death; is life threatening; requires inpatient hospitalization or prolongation of an existing hospitalization; results in persistent or significant disability/incapacity; is a congenital anomaly/birth defect in the offspring of an exposed subject; is medically significant or an important medical event as assessed by investigator or sponsor; is, in the opinion of the investigator, an important medical event. (NCT00661141)
Timeframe: Study Day 0 through Study Visit Day 7
| Intervention | Participants (Count of Participants) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Any AE | Mild AE | Moderate AE | Severe AE | Life-Threatening/Disabling AE | Death | Possibly or Probably Related AE | AE Leading to Study Discontinuation | Serious AE | |
| Antizol 1.0 mg/kg | 13 | 13 | 2 | 0 | 0 | 0 | 13 | 0 | 0 |
| Antizol 3.0 mg/kg | 6 | 6 | 0 | 0 | 0 | 0 | 6 | 0 | 0 |
| Antizol 5.0 mg/kg | 8 | 8 | 0 | 0 | 0 | 0 | 5 | 0 | 0 |
| Overall | 28 | 28 | 7 | 0 | 0 | 0 | 27 | 0 | 0 |
| Pooled Placebo | 21 | 19 | 5 | 0 | 0 | 0 | 18 | 0 | 0 |
15 reviews available for acetaldehyde and Alcoholic Intoxication
| Article | Year |
|---|---|
The application of minerals in managing alcohol hangover: a preliminary review.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Intoxication; Cytokines; Ethanol; Humans; Inflammation; Mi | 2010 |
Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Aldehyd | 2007 |
Psychiatric advances in the understanding and treatment of alcohol dependence.
Topics: Acetaldehyde; Adoption; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcoholism; Antidepressive | 1984 |
Measuring and reporting the concentration of acetaldehyde in human breath.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Breath Tests; Ethanol; Humans; Predictive Value of | 1995 |
Human blood acetaldehyde (update 1992).
Topics: Acetaldehyde; Alcoholic Intoxication; Binding Sites; Blood Cells; Blood Chemical Analysis; Blood Pro | 1993 |
Assessment of ethanol intake. Current tests and new assays on the horizon.
Topics: Acetaldehyde; Alcoholic Intoxication; Biomarkers; Chromatography, Gas; Ethanol; Glycerophospholipids | 1999 |
The role of acetaldehyde in the actions of alcohol (update 2000).
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Alcohol-Induced Disorders; Alcoholic Intoxica | 2001 |
Biochemical detection and monitoring of alcohol abuse and abstinence.
Topics: Acetaldehyde; Alanine Transaminase; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Aspartate | 2001 |
Cardiac metabolsim: its contributions to alcoholic heart disease and myocardial failure.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Calcium; Calcium-Transporting ATPases; Cardiomyopathy | 1978 |
The metabolism of biogenic amines in experimental animals and in human subjects during acute and chronic administration of ethanol.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Aldehyde Oxidoreductases; Animals; Biogenic Amines | 1977 |
Effect of chronic alcohol consumption on ethanol and acetaldehyde metabolism.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohols; Amitrole; Animals; Catalase | 1975 |
[Metabolism of liver proteins in ethanol poisoning].
Topics: Acetaldehyde; Albumins; Alcoholic Intoxication; Animals; Collagen; Disease Models, Animal; Dose-Resp | 1992 |
International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper No. 15/3. Human acetaldehyde levels: aspects of current interest.
Topics: Acetaldehyde; Alcoholic Intoxication; Ethanol; Humans; Mutagens; Protein Binding | 1987 |
Some biochemical effects of ethanol on CNS.
Topics: Acetaldehyde; Acetylcholine; Alcohol Oxidoreductases; Alcoholic Intoxication; Aminobutyrates; Animal | 1974 |
Biologic concomitants of alcoholism. 1.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcoholism; Animals; Blood Glucose; C | 1970 |
4 trials available for acetaldehyde and Alcoholic Intoxication
| Article | Year |
|---|---|
Noni fruit extract ameliorates alcohol-induced hangover symptoms by reducing the concentrations of alcohol and acetaldehyde in a Sprague Dawley rat model and a human intervention study.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Animals; Ethanol; Fruit; Humans; Morinda; Plant Extract | 2023 |
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant | 2014 |
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant | 2014 |
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant | 2014 |
Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Ethanol; Healthy Volunteers; Humans; Male; Panax; Plant | 2014 |
Estrogen-related acetaldehyde elevation in women during alcohol intoxication.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Contraceptives, Oral; Estradiol; Estr | 1996 |
Metabolic studies on the pathogenesis of hangover.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Intoxication; Ethanol; Fatty Acids, Nonesterified; Glucosi | 1974 |
98 other studies available for acetaldehyde and Alcoholic Intoxication
| Article | Year |
|---|---|
Aldehyde dehydrogenase 2-associated changes in pharmacokinetics, locomotor function and peripheral glutamic acid and gamma-aminobutyric acid levels during acute alcohol intoxication in male mice.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial; Animals; Blood Alcohol | 2022 |
Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial; Animals; Asian People; | 2020 |
Rapid Elimination of Blood Alcohol Using Erythrocytes: Mathematical Modeling and In Vitro Study.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Erythrocytes; E | 2017 |
Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current I(K1) in rat ventricular myocytes.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Pota | 2015 |
[Effect of ethanol and its metabolites on acetylcholine-sensitive K(+) channel Kir3.1 protein expression of neonatal rat primary atrial cardiomyocytes].
Topics: Acetaldehyde; Acetylcholine; Alcoholic Intoxication; Animals; Apoptosis; Cells, Cultured; Ethanol; G | 2015 |
Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts.
Topics: Acetaldehyde; Alanine Transaminase; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Oxidored | 2016 |
Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase, Mitochondrial; | 2016 |
Pharmacodynamics & toxicological profile of PartySmart, a herbal preparation for alcohol hangover in Wistar rats.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Animals; Dose-Response Relationship, Dr | 2008 |
Alcohol in Mayan Guatemala: consumption, distribution, production and composition of cuxa.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Cult | 2009 |
Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Cytoch | 2009 |
Acetate causes alcohol hangover headache in rats.
Topics: Acetaldehyde; Acetates; Alcohol Drinking; Alcoholic Intoxication; Analgesia; Animals; Chronic Diseas | 2010 |
[A serious "acetaldehyde syndrome" compounded by dopamine].
Topics: Acetaldehyde; Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Anti-Anxiety Agents; Antidepre | 2011 |
On-line, simultaneous quantification of ethanol, some metabolites and water vapour in breath following the ingestion of alcohol.
Topics: Acetaldehyde; Acetone; Alcoholic Intoxication; Ammonia; Breath Tests; Central Nervous System Depress | 2002 |
Disulfiram-alcohol intoxication; investigation of five fatal cases and the chemical determination of disulfiram and blood acetaldehyde.
Topics: Acetaldehyde; Alcoholic Intoxication; Disulfiram; Humans | 1957 |
[Studies on the acetaldehyde concentration of blood in alcohol intoxication].
Topics: Acetaldehyde; Alcoholic Intoxication; Blood Chemical Analysis; Humans | 1963 |
[Death from acetaldehyde of metabolic origin during acute ethyl alcohol poisoning].
Topics: Acetaldehyde; Alcoholic Intoxication; Child; Death; Ethanol; Humans; Infant; Poisoning | 1955 |
[Variations in pyruvic acid and acetaldehyde blood level in alcoholic aggression].
Topics: Acetaldehyde; Aggression; Alcoholic Intoxication; Humans; Pyruvates; Pyruvic Acid | 1951 |
[Acetaldehyde concentration in acute ethanol-intoxicated patients addicted to alcohol].
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Biomarkers; Ethanol; Humans; Male; Middle A | 2004 |
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Body Temperature; Brain; Cent | 2007 |
Maturation of whisky changes ethanol elimination kinetics and neural effects by increasing nonvolatile congeners.
Topics: Acetaldehyde; Acetates; Alcohol Dehydrogenase; Alcoholic Beverages; Alcoholic Intoxication; Animals; | 2007 |
[Evaluation of ventilation disorders in alcohol addicted males].
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Bi | 2007 |
Occurrence of trace indoles in mammals.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Brain; Carbolines; Formaldehyde; Humans; | 1984 |
Assaying acetaldehyde in biological fluids.
Topics: Acetaldehyde; Alcoholic Intoxication; Ethanol; Humans; Methods | 1981 |
Survival after a blood acetaldehyde concentration of 1750 micrograms/dl.
Topics: Acetaldehyde; Alcoholic Intoxication; Ethanol; Humans; Male; Middle Aged | 1983 |
Cardiovascular effects of acetaldehyde accumulation after ethanol ingestion: their modification by beta-adrenergic blockade and alcohol dehydrogenase inhibition.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Drinking; Alcohol Oxidoreductases; Alcoholic Int | 1983 |
Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese.
Topics: Acetaldehyde; Adult; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohol | 1983 |
Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Ethanol; Humans; Kinetics; Lactates; Lactic | 1984 |
Time course of breath acetaldehyde concentrations during intravenous infusions of ethanol in healthy men.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Breath Tests; Chromatography, Gas; Ethanol; Humans; Mal | 1984 |
Interaction between acetaldehyde and sulfhydryl compounds in human blood during ethanol intoxication.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Drug Interactions; Humans; Sulfhydryl Compounds | 1984 |
Human blood acetaldehyde concentration during ethanol oxidation (update 1982).
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; | 1983 |
Metabolic factors and preference for ethanol.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholic Intoxication; Aldehyde Dehydrogenase; Aldehyde Oxidoreduct | 1983 |
Effect of ethanol on hepatic secretory proteins.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Blood Proteins; Ethanol; Glycoproteins; H | 1984 |
[Permeability of the blood-brain barrier to 3H-GABA during alcoholic intoxication].
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Blood-Brain Barrier; Brain; Caudate Nucleus; Cerebral | 1982 |
Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Blood-Brain Barrier; Ethanol; Fluorescein; Fluorescei | 1981 |
Ethanol and simulated high altitude. A study of three mouse strains.
Topics: Acetaldehyde; Alcoholic Intoxication; Altitude; Animals; Atmospheric Pressure; Behavior, Animal; Eth | 1982 |
Biological markers: metabolism and acute reactions to alcohol in sons of alcoholics.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Ethanol; Humans; Male; Muscle Contraction; Prospec | 1980 |
Difficulties in measuring human blood acetaldehyde concentrations during ethanol intoxication.
Topics: Acetaldehyde; Alcoholic Intoxication; Blood Proteins; Blood Specimen Collection; Ethanol; Humans; Ki | 1980 |
Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Brain Chemistry; Breath Tests; Humans; Male | 1980 |
The acute effects of ethanol and acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Contra | 1995 |
Macrophages are a major source of acetaldehyde in circulating acetaldehyde-albumin complexes formed after exposure of mice to ethanol.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Clodronic Acid; Female; Macrophages; Mice; Mice, Inbr | 1994 |
Occurrence of blood acetaldehyde in women during ethanol intoxication: preliminary findings.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Ethanol; Female; Humans; Sex Factors | 1993 |
[Concentrations of ethanol and ethanol metabolites and symptoms of acute alcohol-intoxicated patients].
Topics: Acetaldehyde; Acetates; Acetone; Adult; Alcoholic Intoxication; Ethanol; Humans; Male; Middle Aged | 1994 |
Problems involved in the determination of endogenous acetaldehyde in human blood.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Chromatography, Gas; Erythrocytes; Et | 1993 |
Influence of pyruvate, threonine and phosphoethanolamine on activities of some acetaldehyde-producing enzymes.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Carbon-Oxygen Lyases; Ethanol; Ethanolamines; Glycine | 1993 |
Pharmacodynamic response to Ro15-4513 in ethanol intoxicated dogs.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Biotransformation; Blood Pre | 1996 |
Effects of tea (Camellia sinensis) chemical compounds on ethanol metabolism in ICR mice.
Topics: Acetaldehyde; Acetates; Acetone; Administration, Oral; Alcoholic Intoxication; Animals; Caffeine; Ca | 1996 |
Transglutaminase activity in rat brain after ethanol exposure.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Brain; Dose-Response Relationship, Drug; | 1997 |
[Effect of liver hydrolysate on ethanol- and acetaldehyde-induced deficiencies].
Topics: Acetaldehyde; Alanine Transaminase; Alcoholic Intoxication; Animals; Aspartate Aminotransferases; Ca | 1998 |
Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute or chronic alcohol abuse: in vivo and in vitro studies.
Topics: Acetaldehyde; Acute Disease; Adult; Alcoholic Intoxication; Alcoholism; Chronic Disease; Erythrocyte | 1997 |
Fatal acute alcohol intoxication in an ALDH2 heterozygote: a case report.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitocho | 2000 |
Electroencephalogram spectral characteristics after alcohol ingestion in Japanese men with aldehyde dehydrogenase-2 genetic variations: comparison with peripheral changes.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Alcoholic Intoxication; Aldehyde Dehydrogenase; Aldehyde Dehy | 2001 |
Concentration of ethanol and other volatile compounds in the blood of acutely poisoned alcoholics.
Topics: 1-Propanol; 2-Propanol; Acetaldehyde; Acetone; Adolescent; Adult; Aged; Alcoholic Intoxication; Alco | 2002 |
[Suppression by ascorbic acid of neuromuscular fatigue due to sound-alcohol synergy].
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Ascorbic Acid; Fatigue; Humans; Inactivation, Metabol | 1978 |
Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Female; Glutamate Dehydrogenase; Humans; In Vitro Tec | 1975 |
The acute toxicity of ethanol: dosage and kinetic nomograms.
Topics: Acetaldehyde; Adolescent; Alcoholic Intoxication; Dose-Response Relationship, Drug; Ethanol; Female; | 1979 |
Acetaldehyde in cerebrospinal fluid: its near-absence in ethanol-intoxicated alcoholics.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Humans; Male; Middle Aged | 1979 |
The cerebral oxidative metabolic response to acute ethanol administration in rats and cats.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Brain; Cats; Chlorpromazine; Cytochromes; Dose-Respon | 1977 |
A possible protective role for sulphydryl compounds in acute alcoholic liver injury.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dos | 1977 |
The presence of an aldehyde dehydrogenase inhibitor in animal diets and its effects on the experimental results in alcohol studies.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Oxidoreductases; Amines; Animals; Cyanides; Diet; Eth | 1978 |
Evidence against a role of acetaldehyde in electroencephalographic signs of ethanol-induced intoxication.
Topics: Acetaldehyde; Action Potentials; Alcoholic Intoxication; Animals; Brain; Dose-Response Relationship, | 1979 |
A mechanism for decreased resistance to infection by gram-negative organisms during acute alcoholic intoxication.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Animals; Bacteria; Bacterial Infections; Blood Bac | 1975 |
The effect of pargyline and other monoamine oxidase inhibitors on blood acetaldehyde levels in ethanol-intoxicated mice.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Oxidoreductases; Animals; Ethanol; Humans; Kinetics; | 1976 |
Alcohol as a euphoriant drug: searching for a neurochemical basis.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Brain; Catecholamines; Dopamine beta-Hydroxylase; Ethan | 1976 |
Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication.
Topics: Acetaldehyde; Alcoholic Intoxication; Alkaloids; Animals; Brain; Brain Stem; Caudate Nucleus; Dopami | 1975 |
Enzymatic production of acetaldehyde from ethanol in rat brain tissue.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Animals; Brain; Catalase; Chromatograph | 1992 |
Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers.
Topics: Acetaldehyde; Acetates; Acetone; Adult; Alcoholic Intoxication; Ethanol; Humans; Male | 1991 |
Volatile compounds detected in blood of drunk drivers by headspace/capillary gas chromatography/ion trap mass spectrometry.
Topics: 1-Propanol; Acetaldehyde; Acetates; Acetone; Alcoholic Intoxication; Automobile Driving; Butanols; B | 1991 |
Degrees of alcohol intoxication in 117 hospitalized cases.
Topics: Acetaldehyde; Adult; Aged; Alcoholic Intoxication; Alcoholism; Ethanol; Flushing; Hospitalization; H | 1991 |
In vivo accelerated acetaldehyde metabolism using acetaldehyde dehydrogenase-loaded erythrocytes.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Oxidoreductases; Animals; Blood Transfusion; Erythroc | 1990 |
Hemoglobin-acetaldehyde adducts in human volunteers following acute ethanol ingestion.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Enzyme-Linked Immunosorbent Assay; Female; Flushing; He | 1990 |
Effects of amino acids on acute alcohol intoxication in mice--concentrations of ethanol, acetaldehyde, acetate and acetone in blood and tissues.
Topics: Acetaldehyde; Acetates; Acetone; Alanine; Alcoholic Intoxication; Amino Acids; Animals; Cysteine; Et | 1990 |
[New methods of pharmacokinetic evaluation of alcohol and its metabolites in female and male probands].
Topics: Acetaldehyde; Acetates; Adult; Alcoholic Intoxication; Ethanol; Female; Humans; Male; Metabolic Clea | 1990 |
Effects of acute ethanol intoxication on aldehyde dehydrogenase in mouse liver.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Ethanol; Liver; Male; Metabol | 1990 |
Characterization of the increased binding of acetaldehyde to red blood cells in alcoholics.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcoholism; Binding Sites; Binding, Competitive; Erythrocytes; | 1989 |
Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; In Vitro Techniques; Lipid Peroxidation; Male; Malond | 1989 |
[Biochemical mechanisms of cell lesions in alcoholism].
Topics: Acetaldehyde; Acetates; Alcoholic Intoxication; Alcoholism; Ethanol; Free Radicals; Humans; Microsom | 1989 |
Changes in the blood of Wistar rats in acute poisoning with ethanol and acetaldehyde.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Erythrocyte Volume; Erythrocytes; Hematocrit; Hemoglo | 1987 |
Experimental studies on the mechanism of ethanol formation in corpses.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcoholic Intoxication; Blood Glucose; Cause of Death; Ethanol; | 1988 |
Platelet function during acetaldehyde intoxication in healthy male volunteers.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaldehyde; Adult; Alcoholic Intoxication; Blood Platelets; Ethanol; | 1987 |
Serotonin condensation product 5-hydroxymethtryptoline: evidence for in vivo formation from acetaldehyde during intoxication using deuterium labelled ethanol.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Carbolines; Ethanol; Gas Chromatography-Mass Spectrom | 1987 |
Effect of acetaldehyde on rat platelet aggregation in vivo and in vitro.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Blood Coagulation; Male; Platelet Aggregation; Rats; | 1987 |
[Influence of acute intake of alcoholic beverages on the cardiovascular system: clinical, electrocardiographic and laboratory observations].
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Arrhythmias, Cardiac; Electrocardiography; Ethanol; Hea | 1986 |
Acute and chronic effect of ethanol on hepatic albumin synthesis in rat liver in vitro.
Topics: Acetaldehyde; Albumins; Alcoholic Intoxication; Alcoholism; Animals; Chromatography, DEAE-Cellulose; | 1986 |
Haematological abnormalities in mice continuously exposed to ethanol vapour.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Bone Marrow; Dose-Response Relationship, Drug; Ethano | 1986 |
Release of acid proteolytic activity from lysosomes and degradation of protein in organs of rats intoxicated with ethanol and acetaldehyde.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Kidney; Liver; Lung; Lysosomes; Octoxynol; Peptide Hy | 1985 |
Suppression of acetaldehyde accumulation by 4-methylpyrazole in alcohol-hypersensitive Japanese.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Flushing; Fomepizole; Heart; Heart Rate; Humans; Male; | 1985 |
Gastric erosions caused by home-brewed lager.
Topics: Acetaldehyde; Acetates; Acetobacter; Adult; Alcoholic Intoxication; Alcohols; Animals; Beer; Chromat | 1971 |
Ethanol and acetaldehyde effects on metabolism and binding of biogenic amines.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Animals; Biogenic Amines; Brain; Brai | 1974 |
Pyrogallol potentiates acetaldehyde blood levels during ethanol oxidation in rats.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Chromatography, Gas; Ethanol; Humans; Male; Pyrogallo | 1974 |
[Acetaldehyde and alcoholism. The pharmacogenesis of the teturam-alcohol reaction and its control by way of binding acetaldehyde with sodium metabisulfite].
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Animals; Disulfiram; Humans; Mice; Sulfites | 1973 |
Adsorption of whisky congeners by activated charcoal. Chemical and clinical studies related to hangover.
Topics: Acetaldehyde; Acetates; Adsorption; Adult; Alcoholic Intoxication; Alcohols; Animals; Charcoal; Etha | 1971 |
Blood methanol concentrations during experimentally induced ethanol intoxication in alcoholics.
Topics: Acetaldehyde; Acetone; Adult; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Chromatograph | 1971 |
Studies on the antidotal action of drugs. 1. Vitamin C and its antidotal effect against alcoholic and nicotine poisoning.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Antidotes; Ascorbic Acid; Cysteine; Drug Synergism; H | 1969 |
Alcohol oxidation in rate inhibited by pyrazole, oximes, and amides.
Topics: 1-Propanol; Acetaldehyde; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohols; Amides; Animals | 1970 |
Effects of alcoholic beverages and congeners on psychomotor skills in old and young subjects.
Topics: Acetaldehyde; Acetates; Adult; Aged; Aging; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; F | 1970 |
Depression of delta-aminolaevulic acid dehydrase activity by ethanol in man and rat.
Topics: Acetaldehyde; Acetates; Adolescent; Adult; Aged; Alcoholic Intoxication; Amino Acids; Animals; Coenz | 1971 |
Analytical research of acute alcoholic intoxication.
Topics: Acetaldehyde; Alcoholic Intoxication; Alcohols; Animals; Chromatography, Gas; Electromyography; Huma | 1967 |
Effect of congeners in alcoholic beverages on the incidence of nystagmus.
Topics: 1-Propanol; Acetaldehyde; Acetates; Adult; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; Et | 1966 |