acetaldehyde has been researched along with Alcoholic Cardiomyopathy in 25 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaldehyde has been demonstrated to impair directly cardiac contractile function, disrupt cardiac excitation-contractile coupling, and contribute to oxidative damage and lipid peroxidation." | 6.42 | Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. ( Brown, RA; Li, SY; Ren, J; Zhang, X, 2004) |
| "Alcoholic cardiomyopathy is characterized by cardiomegaly, disruptions of myofibrillary architecture, reduced myocardial contractility, decreased ejection fraction, and enhanced risk of stroke and hypertension." | 6.42 | Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. ( Brown, RA; Li, SY; Ren, J; Zhang, X, 2004) |
| "To explore the role of acetaldehyde in alcoholic cardiomyopathy, we generated transgenic mice with overexpression of the alcohol-metabolizing enzyme alcohol dehydrogenase (ADH) and the acetaldehyde-metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2), driven by myosin heavy chain and chicken beta-actin promoters, respectively." | 5.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| "Alcoholic cardiomyopathy is manifested as ventricular dysfunction although its pathogenesis remains obscure." | 5.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| "Chronic alcohol intake leads to alcoholic cardiomyopathy characterized by cardiac hypertrophy and contractile dysfunction possibly related to the toxicity of the ethanol metabolite acetaldehyde." | 3.74 | Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. ( Li, SY; Ren, J, 2008) |
| "Alcoholic cardiomyopathy is manifested as cardiac hypertrophy, disrupted contractile function and myofibrillary architecture." | 2.47 | ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. ( Ren, J; Zhang, Y, 2011) |
| "After all, in patients with alcohol abuse and myocarditis the immune functioning appears to be compromised." | 2.39 | [Alcohol and myocarditis]. ( Ferency, I; Kaiser, A; Maisch, B; Wilke, A, 1996) |
| "The risk of developing alcoholic cardiomyopathy is related to both the mean daily alcohol intake and the duration of drinking, but there is much individual susceptibility to the toxic effect of alcohol." | 2.39 | [Alcohol and myocarditis]. ( Ferency, I; Kaiser, A; Maisch, B; Wilke, A, 1996) |
| "Chronic alcohol intake leads to alcoholic cardiomyopathy characterized by cardiac hypertrophy and contractile dysfunction possibly related to the toxicity of the ethanol metabolite acetaldehyde." | 1.35 | Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. ( Li, SY; Ren, J, 2008) |
| "To explore the role of acetaldehyde in alcoholic cardiomyopathy, we generated transgenic mice with overexpression of the alcohol-metabolizing enzyme alcohol dehydrogenase (ADH) and the acetaldehyde-metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2), driven by myosin heavy chain and chicken beta-actin promoters, respectively." | 1.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| "Alcoholic cardiomyopathy is manifested as ventricular dysfunction although its pathogenesis remains obscure." | 1.34 | Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( Ren, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (36.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandt, M | 2 |
| Wenzel, P | 2 |
| Wang, S | 1 |
| Ren, J | 5 |
| Garlapati, V | 1 |
| Oelze, M | 1 |
| Sotiriou, E | 1 |
| Knorr, M | 1 |
| Kröller-Schön, S | 1 |
| Kossmann, S | 1 |
| Schönfelder, T | 1 |
| Morawietz, H | 1 |
| Schulz, E | 1 |
| Schultheiss, HP | 1 |
| Daiber, A | 1 |
| Münzel, T | 1 |
| Zhang, Y | 1 |
| Zhang, X | 1 |
| Li, SY | 2 |
| Brown, RA | 1 |
| Oba, T | 1 |
| Maeno, Y | 1 |
| Ishida, K | 1 |
| Freeman, TL | 1 |
| Tuma, DJ | 1 |
| Thiele, GM | 1 |
| Klassen, LW | 1 |
| Worrall, S | 1 |
| Niemelä, O | 1 |
| Parkkila, S | 1 |
| Emery, PW | 1 |
| Preedy, VR | 4 |
| Cai, L | 1 |
| Kiviluoma, K | 1 |
| Hassinen, I | 1 |
| García-Buñuel, L | 1 |
| Peuhkurinen, KJ | 1 |
| Kiviluoma, KT | 1 |
| Hiltunen, JK | 1 |
| Takala, TE | 1 |
| Hassinen, IE | 1 |
| Klatsky, AL | 1 |
| Otero Chulián, E | 1 |
| Vergara de Campos, A | 1 |
| Harcombe, AA | 1 |
| Ramsay, L | 1 |
| Kenna, JG | 1 |
| Koskinas, J | 1 |
| Why, HJ | 1 |
| Richardson, PJ | 4 |
| Weissberg, PL | 1 |
| Alexander, GJ | 1 |
| Siddiq, T | 1 |
| Mitchell, WD | 1 |
| Teare, J | 1 |
| Wilke, A | 1 |
| Kaiser, A | 1 |
| Ferency, I | 1 |
| Maisch, B | 1 |
| Liang, Q | 1 |
| Carlson, EC | 1 |
| Borgerding, AJ | 1 |
| Epstein, PN | 1 |
| Bing, RJ | 1 |
| Schreiber, SS | 1 |
| Van Thiel, DH | 1 |
| Gavaler, JS | 1 |
| Lehotay, DC | 1 |
| Nuzhnyĭ, VP | 1 |
| Zabirova, IG | 1 |
| Abdrashitov, AKh | 1 |
| Uspenskiĭ, AE | 1 |
11 reviews available for acetaldehyde and Alcoholic Cardiomyopathy
| Article | Year |
|---|---|
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy.
Topics: Acetaldehyde; Animals; Autophagy; Cardiomyopathy, Alcoholic; Disease Models, Animal; Ethanol; Heart | 2018 |
ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Autophagy; Cardiomyopat | 2011 |
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress.
Topics: Acetaldehyde; Animals; Cardiomyopathy, Alcoholic; Ethanol; Humans; Oxidative Stress | 2004 |
Differential contribution of clinical amounts of acetaldehyde to skeletal and cardiac muscle dysfunction in alcoholic myopathy.
Topics: Acetaldehyde; Alcohol Drinking; Cardiomyopathy, Alcoholic; Central Nervous System Depressants; Ethan | 2005 |
The relations of alcohol and the cardiovascular system.
Topics: Acetaldehyde; Alcoholism; Animals; Arteriosclerosis; Beriberi; Blood Pressure; Cardiomyopathy, Alcoh | 1982 |
Ethanol induced cardiovascular disease.
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Cardiomyopathy, Alcoholic; Cardiovascular Diseases; Coro | 1994 |
Alcoholic cardiomyopathy: clinical and experimental pathological changes.
Topics: Acetaldehyde; Animals; Biopsy; Cardiomyopathy, Alcoholic; Cardiomyopathy, Dilated; Ethanol; Heat-Sho | 1996 |
[Alcohol and myocarditis].
Topics: Acetaldehyde; Alcoholism; Biopsy; Cardiomyopathy, Alcoholic; Electrocardiography; Endocardium; Ethan | 1996 |
Cardiac metabolsim: its contributions to alcoholic heart disease and myocardial failure.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Calcium; Calcium-Transporting ATPases; Cardiomyopathy | 1978 |
Ethanol, acetaldehyde and cardiac protein synthesis: the relation to cardiomyopathy.
Topics: Acetaldehyde; Cardiomyopathy, Alcoholic; Humans; Muscles; Myocardium; Protein Biosynthesis | 1989 |
Biochemical mechanisms responsible for alcohol-associated myocardiopathy.
Topics: Acetaldehyde; Animals; Calcium; Cardiomyopathy, Alcoholic; Contractile Proteins; Ethanol; Fatty Acid | 1985 |
14 other studies available for acetaldehyde and Alcoholic Cardiomyopathy
| Article | Year |
|---|---|
Alcohol puts the heart under pressure: Acetaldehyde activates a localized renin angiotensin aldosterone system within the myocardium in alcoholic cardiomyopathy.
Topics: Acetaldehyde; Angiotensin II; Blood Pressure; Cardiomyopathy, Alcoholic; Ethanol; Humans; Myocardium | 2018 |
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiomyopathy, Alcoholic; Disease Mod | 2016 |
Recent advances in alcohol-induced adduct formation.
Topics: Acetaldehyde; Alcohol-Related Disorders; Alcoholism; Animals; Cardiomyopathy, Alcoholic; DNA Adducts | 2005 |
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; | 2007 |
Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress.
Topics: Acetaldehyde; Adaptor Proteins, Signal Transducing; Alcohol Dehydrogenase; Animals; Cardiomyopathy, | 2008 |
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress.
Topics: Acetaldehyde; Adaptor Proteins, Signal Transducing; Alcohol Dehydrogenase; Animals; Cardiomyopathy, | 2008 |
Role of acetaldehyde and acetate in the development of ethanol-induced cardiac lipidosis, studied in isolated perfused rat hearts.
Topics: Acetaldehyde; Acetates; Aldehyde Oxidoreductases; Animals; Cardiomyopathy, Alcoholic; Female; Mitoch | 1983 |
Lipid peroxidation in alcoholic myopathy and cardiomyopathy.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholism; Animals; Cardiomyopathy, Alcoholic; Catalase; Eth | 1984 |
Effects of ethanol metabolites on intermediary metabolism in heart muscle.
Topics: Acetaldehyde; Acetates; Animals; Cardiomyopathy, Alcoholic; Ethanol; Fatty Acids; Myocardium; NAD; O | 1983 |
[Alcoholic cardiomyopathy. II. Current concept. Metabolism of ethanol].
Topics: Acetaldehyde; Cardiomyopathy, Alcoholic; Ethanol; Humans; Myocardium | 1983 |
Circulating antibodies to cardiac protein-acetaldehyde adducts in alcoholic heart muscle disease.
Topics: Acetaldehyde; Adult; Aged; Antibodies; Biomarkers; Blotting, Western; Cardiomyopathy, Alcoholic; Cyt | 1995 |
Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde.
Topics: Acetaldehyde; Animals; Cardiomyopathy, Alcoholic; Cyanamide; Depression, Chemical; Ethanol; Fomepizo | 1993 |
A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy.
Topics: Acetaldehyde; Actins; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiomyopathy, Alcoholic; D | 1999 |
[Determination of the leading factors in the pathogenesis of an alcoholic lesion of the heart].
Topics: Acetaldehyde; Acetone; Animals; Cardiomyopathy, Alcoholic; Dose-Response Relationship, Drug; Ethanol | 1989 |