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acetaldehyde and Aging

acetaldehyde has been researched along with Aging in 26 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The purpose of the study is to identify the sites of modification when fibronectin reacts with glycolaldehyde or methylglyoxal as a model system for aging of Bruch's membrane."7.83The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane. ( Gaillard, ER; Thao, MT, 2016)
" The purpose of this study was to investigate modifications from glycolaldehyde and A2E, which are present in the retinal pigment epithelium (RPE), on the membrane like protein fragment, laminin, as a model for aging of Bruch's membrane in age related eye diseases."7.75Modifications to the basement membrane protein laminin using glycolaldehyde and A2E: a model for aging in Bruch's membrane. ( Dillon, J; Gaillard, ER; Murdaugh, LS, 2009)
"The purpose of the study is to identify the sites of modification when fibronectin reacts with glycolaldehyde or methylglyoxal as a model system for aging of Bruch's membrane."3.83The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane. ( Gaillard, ER; Thao, MT, 2016)
" The purpose of this study was to investigate modifications from glycolaldehyde and A2E, which are present in the retinal pigment epithelium (RPE), on the membrane like protein fragment, laminin, as a model for aging of Bruch's membrane in age related eye diseases."3.75Modifications to the basement membrane protein laminin using glycolaldehyde and A2E: a model for aging in Bruch's membrane. ( Dillon, J; Gaillard, ER; Murdaugh, LS, 2009)
" The reactivity of these groups not only has an important role in the maintenance of mechanical strength in collagen fibrils, but can also manifest pathologically in the cases of aging, diabetes (reactivity with a variety of sugars) and alcoholism (reactivity with acetaldehyde)."3.69The chemical reactivity and structure of collagen studied by neutron diffraction. ( Miller, A; Wess, L; Wess, TJ, 1996)
"The frequent use of alcohol (ethanol) together with prescription drugs gives any described pharmacokinetic interaction significant clinical implications."2.40Pharmacokinetic interactions between alcohol and other drugs. ( Fraser, AG, 1997)
"Thus acetaldehyde was more stimulatory in young and more inhibitory in the adult brain areas tested, which could explain its stimulating nicotine reward only in young animals."1.35The effects of acetaldehyde on nicotine-induced transmitter levels in young and adult brain areas. ( Chakraborty, G; Fallon, S; Lajtha, A; Sershen, H; Shearman, E; Smiley, J, 2009)
"25 kg (designated mature) body weight (BW) were dosed acutely with alcohol (75 mmol/kg BW; intraperitoneal [IP], 2."1.31Effect of acute and chronic alcohol treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo. ( Ahmed, S; Donohue, TM; Koll, M; Mantle, D; Palmer, TN; Peters, TJ; Preedy, VR; Seltz, HK; Simanowski, UA, 2002)
"Glycolaldehyde was used to modify bovine serum albumin and HPLC analysis was used to measure pentosidine formation as an indicator of AGE formation."1.30Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye. ( Aotaki-Keen, A; Farboud, B; Handa, JT; Hjelmeland, LM; Miyata, T, 1999)
" In 8-week-old animals, however, acetaldehyde or ethanol given with MPTP decreased striatal DA content to about 10% of controls, whereas the depletion was to 43% of controls when MPTP was given alone."1.28MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra. ( Corsini, GU; di Porzio, U; Johannessen, JN; Kopin, IJ; Schinelli, S; Zuddas, A, 1989)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19905 (19.23)18.7374
1990's9 (34.62)18.2507
2000's10 (38.46)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thao, MT1
Gaillard, ER2
Murdaugh, LS1
Dillon, J1
Sershen, H1
Shearman, E1
Fallon, S1
Chakraborty, G1
Smiley, J1
Lajtha, A1
Garaycoechea, JI1
Crossan, GP1
Langevin, F1
Daly, M1
Arends, MJ1
Patel, KJ1
Nishimura, FT1
Fukunaga, T1
Yokomukai, Y1
Kajiura, H1
Ono, T1
Nishijo, H1
Akimoto, T1
Cho, S1
Yoshida, H1
Furuta, H1
Esashi, Y1
Kim, JM1
Stewart, R1
Shin, IS1
Jung, JS1
Yoon, JS1
Belluzzi, JD2
Wang, R1
Leslie, FM2
Poon, HF1
Farr, SA1
Banks, WA1
Pierce, WM1
Klein, JB1
Morley, JE1
Butterfield, DA1
Park, MK1
Han, SH1
Cao, J1
Chrostek, L1
Cylwik, B1
Szmitkowski, M1
Messiha, FS1
Simanowski, UA2
Suter, P1
Russell, RM1
Heller, M1
Waldherr, R1
Ward, R1
Peters, TJ2
Smith, D1
Seitz, HK1
Tan, XX1
Castoldi, AF1
Manzo, L1
Costa, LG1
Devi, GU2
Indira, K2
Babu, GR2
Chetty, CS2
Wess, TJ1
Wess, L1
Miller, A1
Fraser, AG1
Farboud, B1
Aotaki-Keen, A1
Miyata, T1
Hjelmeland, LM1
Handa, JT1
Koll, M1
Ahmed, S1
Mantle, D1
Donohue, TM1
Palmer, TN1
Seltz, HK1
Preedy, VR1
Tesco, G1
Latorraca, S1
Piersanti, P1
Piacentini, S1
Amaducci, L1
Sorbi, S1
Rikans, LE1
Snowden, CD1
Moore, DR1
Zuddas, A1
Corsini, GU1
Schinelli, S1
Johannessen, JN1
di Porzio, U1
Kopin, IJ1
Hesselbrock, VM1
Shaskan, EG1
Crompton, M1
Laties, GG1
Wilson, AS1
Barboriak, JJ1
Kass, WA1

Reviews

2 reviews available for acetaldehyde and Aging

ArticleYear
[Age and ethanol metabolism].
    Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 115, Issue:1

    Topics: Acetaldehyde; Aged; Aging; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Central Nervous

2006
Pharmacokinetic interactions between alcohol and other drugs.
    Clinical pharmacokinetics, 1997, Volume: 33, Issue:2

    Topics: Acetaldehyde; Aging; Alcohol Dehydrogenase; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroida

1997

Other Studies

24 other studies available for acetaldehyde and Aging

ArticleYear
The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane.
    Amino acids, 2016, Volume: 48, Issue:7

    Topics: Acetaldehyde; Aging; Bruch Membrane; Fibronectins; Humans; Models, Biological; Pyruvaldehyde

2016
Modifications to the basement membrane protein laminin using glycolaldehyde and A2E: a model for aging in Bruch's membrane.
    Experimental eye research, 2009, Volume: 89, Issue:2

    Topics: Acetaldehyde; Aging; Bruch Membrane; Eye Proteins; Glycation End Products, Advanced; Humans; Laminin

2009
The effects of acetaldehyde on nicotine-induced transmitter levels in young and adult brain areas.
    Brain research bulletin, 2009, Aug-14, Volume: 79, Issue:6

    Topics: Acetaldehyde; Aging; Animals; Brain; Catheterization; Central Nervous System Agents; Dopamine; Hippo

2009
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.
    Nature, 2012, Sep-27, Volume: 489, Issue:7417

    Topics: Acetaldehyde; Aging; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Anima

2012
Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations.
    Alcoholism, clinical and experimental research, 2003, Volume: 27, Issue:5

    Topics: Acetaldehyde; Adult; Aging; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitoch

2003
Involvement of acetaldehyde in seed deterioration of some recalcitrant woody species through the acceleration of aerobic respiration.
    Plant & cell physiology, 2004, Volume: 45, Issue:2

    Topics: Acetaldehyde; Aerobiosis; Aging; Cell Survival; Cellular Senescence; Enzymes; Oxidative Phosphorylat

2004
Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
    Neurobiology of aging, 2004, Volume: 25, Issue:3

    Topics: Acetaldehyde; Age Factors; Aged; Aging; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Aldehy

2004
Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Acetaldehyde; Adolescent; Age Factors; Aging; Animals; Brain; Brain Chemistry; Cocaine; Disease Mode

2005
Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein.
    Brain research. Molecular brain research, 2005, Jul-29, Volume: 138, Issue:1

    Topics: Acetaldehyde; Aging; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Brain; Electrophore

2005
Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 86, Issue:2

    Topics: Acetaldehyde; Aging; Animals; Animals, Newborn; Behavior, Animal; Catheterization, Peripheral; Corti

2007
Development and kinetic aspects of rat eye aldehyde dehydrogenase.
    The International journal of biochemistry, 1982, Volume: 14, Issue:1

    Topics: Acetaldehyde; Aging; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Eye; Female; Kinetic

1982
Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats.
    Gut, 1994, Volume: 35, Issue:8

    Topics: Acetaldehyde; Aging; Animals; Cell Division; Ethanol; Intestinal Mucosa; Male; Rats; Rats, Inbred F3

1994
Interaction of ethanol with muscarinic receptor-stimulated phosphoinositide metabolism during the brain growth spurt in the rat: role of acetaldehyde.
    Neuroscience letters, 1993, Jun-25, Volume: 156, Issue:1-2

    Topics: 1-Propanol; Acetaldehyde; Aging; Aldehydes; Animals; Brain; Carbachol; Cerebellum; Cerebral Cortex;

1993
Age-related metabolic effects of acetaldehyde on rats with reference to detoxification enzymes and sulfhydryl groups.
    Biomedical and environmental sciences : BES, 1996, Volume: 9, Issue:4

    Topics: Acetaldehyde; Aging; Animals; Female; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase

1996
Effect of acetaldehyde on oxidoreductases in tissues of rats at different ages.
    Biomedical and environmental sciences : BES, 1996, Volume: 9, Issue:4

    Topics: Acetaldehyde; Aging; Animals; Female; Oxidoreductases; Rats; Rats, Wistar

1996
The chemical reactivity and structure of collagen studied by neutron diffraction.
    Basic life sciences, 1996, Volume: 64

    Topics: Acetaldehyde; Aging; Alcoholism; Animals; Collagen; Crystallography; Deuterium; Diabetes Mellitus, T

1996
Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye.
    Molecular vision, 1999, Jul-14, Volume: 5

    Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Aging; Animals; Antibodies; Antibody Specificity; Argi

1999
Effect of acute and chronic alcohol treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:1

    Topics: Acetaldehyde; Aging; Animals; Cysteine Endopeptidases; Cytoplasm; Drug Administration Schedule; Endo

2002
Alzheimer skin fibroblasts show increased susceptibility to free radicals.
    Mechanisms of ageing and development, 1992, Volume: 66, Issue:2

    Topics: Acetaldehyde; Aging; Alzheimer Disease; Cell Line; Cell Survival; Fibroblasts; Free Radical Scavenge

1992
Influence of aging on ethanol and acetaldehyde oxidation in female rat liver.
    Gerontology, 1990, Volume: 36, Issue:4

    Topics: Acetaldehyde; Aging; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Aldehyde Dehydrogenase; Animals

1990
MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra.
    Brain research, 1989, Oct-30, Volume: 501, Issue:1

    Topics: Acetaldehyde; Aging; Animals; Dopamine; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL;

1989
Endogenous breath acetaldehyde levels among alcoholic and non-alcoholic probands: effect of alcohol use and smoking.
    Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:3

    Topics: Acetaldehyde; Adolescent; Adult; Aged; Aging; Alcohol Drinking; Alcoholism; Breath Tests; Female; Hu

1985
The regulatory function of potato pyruvate dehydrogenase.
    Archives of biochemistry and biophysics, 1971, Volume: 143, Issue:1

    Topics: Acetaldehyde; Adenine Nucleotides; Adenosine Triphosphate; Aerobiosis; Aging; Anaerobiosis; Buffers;

1971
Effects of alcoholic beverages and congeners on psychomotor skills in old and young subjects.
    Quarterly journal of studies on alcohol, 1970, Volume: 5

    Topics: Acetaldehyde; Acetates; Adult; Aged; Aging; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; F

1970