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acetaldehyde and Acute Liver Injury, Drug-Induced

acetaldehyde has been researched along with Acute Liver Injury, Drug-Induced in 31 studies

Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.

Research Excerpts

ExcerptRelevanceReference
"The equimolar produced metabolite DCCTX was chosen to reflect chloroacetaldehyde (CAA, a toxic metabolite of CTX) production in rats."1.48Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain. ( Chen, L; Chen, W; Feng, G; Gao, S; Yin, J; Zhai, J; Zhang, F, 2018)
"Vinyl chloride (VC) is a ubiquitous environmental contaminant for which human risk is incompletely understood."1.43Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice. ( Anders, LC; Anwar-Mohamed, A; Arteel, GE; Beier, JI; Bushau, AM; Cave, M; Douglas, AN; Falkner, KC; Hill, BG; Lang, AL; McClain, CJ; Warner, NL, 2016)
"Unlike the action of alcohol treatment on fatty liver, BFSP administration attenuated lipid droplet accumulation in hepatocytes."1.38Hepatoprotective effects on alcoholic liver disease of fermented silkworms with Bacillus subtilis and Aspergillus kawachii. ( Cha, JY; Cho, YS; Kim, YS; Moon, HI, 2012)
"Phenobarbital pretreatment of the rats did not affect any of these kinetic parameters."1.28Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol. ( Dunbar, D; Fraser, JM; Kaminsky, LS; Seaman, M, 1992)
" The enzymes involved in the toxic metabolic pathway have been investigated in this study."1.28Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol. ( Dunbar, D; Fraser, JM; Kaminsky, LS; Seaman, M, 1992)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199013 (41.94)18.7374
1990's5 (16.13)18.2507
2000's3 (9.68)29.6817
2010's8 (25.81)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Song, XY1
Liu, PC1
Liu, WW1
Hayashi, T1
Mizuno, K1
Hattori, S1
Fujisaki, H1
Ikejima, T1
Park, SH1
Seo, W1
Xu, MJ1
Mackowiak, B1
Lin, Y1
He, Y1
Fu, Y1
Hwang, S1
Kim, SJ1
Guan, Y1
Feng, D1
Yu, L1
Lehner, R1
Liangpunsakul, S1
Gao, B2
Zhai, J1
Zhang, F1
Gao, S1
Chen, L1
Feng, G1
Yin, J1
Chen, W1
Wei, J1
Huang, Q1
Huang, R1
Chen, Y1
Lv, S1
Wei, L1
Liang, C1
Liang, S1
Zhuo, L1
Lin, X1
Kwon, HJ1
Won, YS1
Park, O1
Chang, B1
Duryee, MJ1
Thiele, GE1
Matsumoto, A1
Singh, S1
Abdelmegeed, MA1
Song, BJ2
Kawamoto, T1
Vasiliou, V1
Thiele, GM1
Xie, W1
Sun, J1
Zhang, X1
Melzig, MF1
Anders, LC1
Lang, AL1
Anwar-Mohamed, A1
Douglas, AN1
Bushau, AM1
Falkner, KC1
Hill, BG1
Warner, NL1
Arteel, GE1
Cave, M1
McClain, CJ1
Beier, JI1
Zhang, YJ1
Wang, F1
Zhou, Y1
Li, Y1
Zhou, T1
Zheng, J1
Zhang, JJ1
Li, S1
Xu, DP1
Li, HB1
Upreti, VV1
Eddington, ND1
Moon, KH1
Lee, IJ1
Cha, JY1
Kim, YS1
Moon, HI1
Cho, YS1
Guo, Y1
Wu, XQ1
Zhang, C1
Liao, ZX1
Wu, Y1
Wang, H1
Nakamura, Y1
Yokoyama, H2
Higuchi, S1
Hara, S1
Kato, S2
Ishii, H2
Vassallo, JD1
Hicks, SM1
Daston, GP1
Lehman-McKeeman, LD1
Nagata, S1
Kamegaya, K1
Tsuchiya, M1
Matysiak-Budnik, T1
Jokelainen, K1
Kärkkäinen, P1
Mäkisalo, H1
Ohisalo, J1
Salaspuro, M1
Löf, K1
Lindros, K1
Seppa, K1
Fukunaga, T1
Badger, T1
Ronis, M1
Sillanaukee, P1
Moura, D1
Azevedo, I1
Osswald, W1
Leeve, CM1
Zetterman, R1
Taskaev, II1
Braun, R1
Greeff, U1
Netter, KJ1
Macdonald, CM1
Dow, J1
Moore, MR1
Bossone, CM1
Zetterman, RK1
Leevy, CM2
Maling, HM1
Stripp, B1
Sipes, IG1
Highman, B1
Saul, W1
Williams, MA1
Kaminsky, LS1
Fraser, JM1
Seaman, M1
Dunbar, D1
Trudell, JR1
Ardies, CM1
Anderson, WR1
Hobara, N1
Freundt, KJ1
Lieberwirth, H1
Myerson, RM1
Sorrell, MF1
Gincheva, NA1

Reviews

2 reviews available for acetaldehyde and Acute Liver Injury, Drug-Induced

ArticleYear
Immunologic reactivity and alcoholic liver disease.
    Bulletin of the New York Academy of Medicine, 1975, Volume: 51, Issue:4

    Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; B-Lymphocytes; Caffeine; Chemical and Drug Ind

1975
Metabolic aspects of alcohol and their biological significance.
    The Medical clinics of North America, 1973, Volume: 57, Issue:4

    Topics: Acetaldehyde; Alcohol Oxidoreductases; Alcoholism; Animals; Bone and Bones; Cardiomyopathies; Catala

1973

Other Studies

29 other studies available for acetaldehyde and Acute Liver Injury, Drug-Induced

ArticleYear
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission.
    Toxicology in vitro : an international journal published in association with BIBRA, 2022, Volume: 80

    Topics: Acetaldehyde; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Chemical and Drug Induced Liver I

2022
Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis.
    Cellular and molecular gastroenterology and hepatology, 2023, Volume: 15, Issue:2

    Topics: Acetaldehyde; Adipocytes; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Str

2023
Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain.
    Journal of ethnopharmacology, 2018, Jan-10, Volume: 210

    Topics: Acetaldehyde; Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Brain; Chemical and Drug

2018
Asiatic acid from Potentilla chinensis attenuate ethanol-induced hepatic injury via suppression of oxidative stress and Kupffer cell activation.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:12

    Topics: Acetaldehyde; Animals; Catalase; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; En

2013
Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:1

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc

2014
Necrosis factor-alpha (TNF-alpha) response in human hepatoma HepG2 cells treated with hepatotoxic agents.
    Die Pharmazie, 2014, Volume: 69, Issue:5

    Topics: Acetaldehyde; Acetaminophen; Cell Line; Cell Survival; Central Nervous System Depressants; Chemical

2014
Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 151, Issue:2

    Topics: Acetaldehyde; AMP-Activated Protein Kinases; Animals; Carbohydrate Metabolism; Chemical and Drug Ind

2016
Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts.
    International journal of environmental research and public health, 2016, Apr-01, Volume: 13, Issue:4

    Topics: Acetaldehyde; Alanine Transaminase; Alcohol Dehydrogenase; Alcoholic Intoxication; Aldehyde Oxidored

2016
Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy").
    Toxicology letters, 2009, Jul-24, Volume: 188, Issue:2

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc

2009
Hepatoprotective effects on alcoholic liver disease of fermented silkworms with Bacillus subtilis and Aspergillus kawachii.
    International journal of food sciences and nutrition, 2012, Volume: 63, Issue:5

    Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Animals; Antioxidants; Aspartate Amin

2012
Protective effect of sodium ferulate on acetaldehyde-treated precision-cut rat liver slices.
    Journal of medicinal food, 2012, Volume: 15, Issue:6

    Topics: Acetaldehyde; Actins; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Collagen; Couma

2012
Acetaldehyde accumulation suppresses Kupffer cell release of TNF-Alpha and modifies acute hepatic inflammation in rats.
    Journal of gastroenterology, 2004, Volume: 39, Issue:2

    Topics: Acetaldehyde; Animals; Blotting, Northern; Cell Culture Techniques; Chemical and Drug Induced Liver

2004
Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 80, Issue:2

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Oxidase; Animals; Anticoagulants; Chemical and Drug I

2004
Experimental hepatitis induced by ethanol after immunization with acetaldehyde adducts.
    Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:1

    Topics: Acetaldehyde; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Ethanol; Female; Guinea P

1993
Hepatotoxicity and absorption of extrahepatic acetaldehyde in rats.
    The Journal of pathology, 1996, Volume: 178, Issue:4

    Topics: Absorption; Acetaldehyde; Animals; Chemical and Drug Induced Liver Injury; Colon; Dose-Response Rela

1996
The effect of ethanol or hepatotoxin exposure on rat transferrin desialylation.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1996, Volume: 31, Issue:5

    Topics: Acetaldehyde; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethan

1996
Hepatotoxicity of the condensation product of adrenaline with acetaldehyde.
    The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:4

    Topics: Acetaldehyde; Animals; Chemical and Drug Induced Liver Injury; Epinephrine; Liver; Liver Diseases; M

1977
Alcoholic hepatitis, cirrhosis, and immunologic reactivity.
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Acetaldehyde; Alcoholism; B-Lymphocytes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Co

1975
[Histochemical and cytologic changes in the liver in experimental poisoning and subsequent pregnancy].
    Arkhiv anatomii, gistologii i embriologii, 1979, Volume: 76, Issue:2

    Topics: Acetaldehyde; Animals; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Chronic Disease; Fem

1979
Liver injury by the false morel poison gyromitrin.
    Toxicology, 1979, Volume: 12, Issue:2

    Topics: Acetaldehyde; Aminopyrine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme

1979
A possible protective role for sulphydryl compounds in acute alcoholic liver injury.
    Biochemical pharmacology, 1977, Aug-15, Volume: 26, Issue:16

    Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dos

1977
The liver: a pharmacologic perspective.
    The Nursing clinics of North America, 1977, Volume: 12, Issue:2

    Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec

1977
Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol.
    Toxicology and applied pharmacology, 1975, Volume: 33, Issue:2

    Topics: 1-Propanol; Acetaldehyde; Acetamides; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning;

1975
Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol.
    Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9

    Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Biotransformation; Chemical and Drug Induced Liver In

1992
The effect of alcohol and anesthetic metabolites on cell membranes. A possible direct immune mechanism.
    Annals of the New York Academy of Sciences, 1991, Volume: 625

    Topics: Acetaldehyde; Alcoholism; Animals; Antibody Formation; Cell Membrane; Chemical and Drug Induced Live

1991
Acetaldehyde metabolism in liver injury.
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1985, Volume: 20, Issue:1

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Chemical and Drug Induced Liver Injury; Ethanol; Live

1985
Proceedings: Influence of inhaled carbon disulphide on acetaldehyde production and liver function in alcoholized man.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl

    Topics: Acetaldehyde; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Bl

1974
Lymphocyte transformation and alcoholic liver injury.
    Gastroenterology, 1972, Volume: 63, Issue:6

    Topics: Acetaldehyde; Alcoholism; Cells, Cultured; Chemical and Drug Induced Liver Injury; DNA; Ethanol; Fat

1972
[Toxicological characteristics of the products of the thermal destruction of polyethylene-terephthalate].
    Gigiena truda i professional'nye zabolevaniia, 1971, Volume: 15, Issue:11

    Topics: Acetaldehyde; Air Pollution; Animals; Body Temperature; Body Weight; Chemical and Drug Induced Liver

1971