acenocoumarol and Vascular-Diseases

Topics: Acenocoumarol; Algorithms; Anticoagulants; Blood Coagulation Disorders; Cross-Sectional Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Drug Administration Schedule; Genotype; Humans; Pharmacogenetics; Phenprocoumon; Polymorphism, Single Nucleotide; Vascular Diseases

To determine guidelines for administering and monitoring acenocoumarol therapy in children, 93 patients (median 5.1 years, range: 0.2-18 years) were prospectively evaluated over a 33-month period. The loading doses used were: <1 year, 0.20 mg x kg-1; >1-5 years, 0.09 mg x kg-1; 6-10 years, 0.07 mg x kg-1; 11-18 years, 0.06 mg x kg-1. In this study, the loading dose and the dose to achieve and maintain target therapeutic range (TTR) for acenocoumarol are age-dependent, with infants having the highest and teenagers having the lowest requirements. The use of a different loading dose according to age has allowed most of the children (80%) in all the age groups to achieve TTR in less than 1 week. No patients had serious bleeding or thrombotic complications. We conclude that there is an age-dependent response to acenocoumarol in pediatric patients. The implementation of an age-adjusted loading dose regimen reduces the length of hospitalization required to achieve effective anticoagulant therapy.

Topics: Acenocoumarol; Adolescent; Age Factors; Anticoagulants; Child; Child, Preschool; Female; Humans; Infant; Male; Thromboembolism; Treatment Outcome; Vascular Diseases

Topics: Acenocoumarol; Anticoagulants; Heparin; Humans; Postoperative Care; Preoperative Care; Thrombelastography; Thrombosis; Vascular Diseases

Topics: Acenocoumarol; Anticoagulants; Cardiovascular Diseases; Humans; Leg; Long-Term Care; Lower Extremity; Vascular Diseases

Topics: Acenocoumarol; Anticoagulants; Audiometry; Basilar Artery; Deafness; Hearing Loss; Hearing Loss, Sudden; Heparin; Humans; Injections, Intravenous; Prothrombin Time; Tinnitus; Vascular Diseases

Topics: Acenocoumarol; Amputation, Surgical; Anticoagulants; Blood Vessels; Drug Therapy; Embolism; Surgeons; Vascular Diseases; Vascular Surgical Procedures

Topics: Acenocoumarol; Anticoagulants; Coronary Disease; Coumarins; Peripheral Vascular Diseases; Thromboembolism; Vascular Diseases