acenocoumarol and Skin-Diseases

acenocoumarol has been researched along with Skin-Diseases* in 9 studies

Reviews

1 review(s) available for acenocoumarol and Skin-Diseases

Article	Year
Problems of oral anticoagulation in an adult with homozygous protein C deficiency and late onset of thrombosis. Thrombosis and haemostasis, 1993, Apr-01, Volume: 69, Issue:4 We describe a 57-year-old woman with homozygous protein C deficiency and mild thrombotic manifestations consisting of three spontaneous distal deep vein thromboses occurring after the age of 45. Previous surgery and pregnancies had been uneventful. Low but detectable protein C antigen and activity levels (both 20%) were discovered on the occasion of skin necrosis induced by oral anticoagulation. This therapy was interrupted because of skin necrosis and several episodes of disseminated intravascular coagulation (DIC) at the initiation of treatment despite a cautious protocol. No recurrent thromboembolic event has occurred in our patient using prophylactic doses of low molecular weight heparin for 24 months. New therapeutic approaches might be the administration of low molecular weight heparin or oral anticoagulation associated with protein C replacement in the induction period. This case reflects the variability of expression of protein C deficiency as well as the potential hazards of antivitamin K anticoagulation in this disorder. Topics: Acenocoumarol; Administration, Oral; Age Factors; Blood Coagulation Disorders; Contraindications; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Heparin; Homozygote; Humans; Middle Aged; Necrosis; Protein C Deficiency; Skin; Skin Diseases; Thrombophlebitis; Warfarin	1993

Article

Year

Problems of oral anticoagulation in an adult with homozygous protein C deficiency and late onset of thrombosis.

Thrombosis and haemostasis, 1993, Apr-01, Volume: 69, Issue:4

We describe a 57-year-old woman with homozygous protein C deficiency and mild thrombotic manifestations consisting of three spontaneous distal deep vein thromboses occurring after the age of 45. Previous surgery and pregnancies had been uneventful. Low but detectable protein C antigen and activity levels (both 20%) were discovered on the occasion of skin necrosis induced by oral anticoagulation. This therapy was interrupted because of skin necrosis and several episodes of disseminated intravascular coagulation (DIC) at the initiation of treatment despite a cautious protocol. No recurrent thromboembolic event has occurred in our patient using prophylactic doses of low molecular weight heparin for 24 months. New therapeutic approaches might be the administration of low molecular weight heparin or oral anticoagulation associated with protein C replacement in the induction period. This case reflects the variability of expression of protein C deficiency as well as the potential hazards of antivitamin K anticoagulation in this disorder.

Topics: Acenocoumarol; Administration, Oral; Age Factors; Blood Coagulation Disorders; Contraindications; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Heparin; Homozygote; Humans; Middle Aged; Necrosis; Protein C Deficiency; Skin; Skin Diseases; Thrombophlebitis; Warfarin

1993

Other Studies

8 other study(ies) available for acenocoumarol and Skin-Diseases

Article	Year
Possible interaction between topical terbinafine and acenocoumarol. The Annals of pharmacotherapy, 2009, Volume: 43, Issue:11 Topics: Acenocoumarol; Administration, Topical; Aged; Drug Interactions; Hemorrhage; Humans; Male; Naphthalenes; Skin Diseases; Terbinafine	2009
Extensive coumarin-induced skin necrosis in a patient with acquired protein C deficiency. Intensive care medicine, 2001, Volume: 27, Issue:9 Topics: Acenocoumarol; Anticoagulants; Atrial Fibrillation; Fatal Outcome; Female; Humans; Liver Cirrhosis, Alcoholic; Middle Aged; Necrosis; Protein C Deficiency; Skin Diseases	2001
Repeated occurrence of skin necrosis twice following coumarin intake and subsequently during decrease of vitamin K dependent coagulation factors associated with cholestasis. Thrombosis and haemostasis, 1982, Dec-27, Volume: 48, Issue:3 A female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol. Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded. This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy. Topics: Acenocoumarol; Adipose Tissue; Adult; Blood Coagulation Factors; Cholestasis; Drug Therapy, Combination; Female; Heparin; Humans; Necrosis; Recurrence; Skin Diseases; Thrombophlebitis; Vitamin K	1982
[Necrosis of the skin after 3 year's treatment with acenocoumarin]. Nederlands tijdschrift voor geneeskunde, 1974, Apr-06, Volume: 118, Issue:14 Topics: Acenocoumarol; Aged; Female; Humans; Necrosis; Pulmonary Embolism; Skin Diseases; Sodium Salicylate	1974
[An unusual anticoagulant complication: total mammary necrosis]. Wiener klinische Wochenschrift, 1967, Sep-15, Volume: 79, Issue:37 Topics: Acenocoumarol; Breast Diseases; Female; Humans; Middle Aged; Necrosis; Skin; Skin Diseases; Thrombophlebitis	1967
PETECHIAE, ECCHYMOSES, AND NECROSIS OF SKIN INDUCED BY COUMARIN CONGENERS: RARE, OCCASIONALLY LETHAL COMPLICATION OF ANTICOAGULANT THERAPY. JAMA, 1965, May-17, Volume: 192 Topics: Acenocoumarol; Anticoagulants; Coumarins; Dicumarol; Drug Therapy; Ecchymosis; Ethyl Biscoumacetate; Gangrene; Necrosis; Phenindione; Pulmonary Embolism; Purpura; Skin Diseases; Thrombophlebitis; Toxicology; Warfarin	1965
[Hemorrhagic skin necrosis during Syncumar therapy]. Orvosi hetilap, 1965, Nov-21, Volume: 106, Issue:47 Topics: Acenocoumarol; Adult; Female; Hemorrhage; Humans; Skin Diseases	1965
[Cutaneous necrosis due to anticoagulants]. Acta chirurgica Belgica, 1965, Volume: 64, Issue:6 Topics: Acenocoumarol; Female; Humans; Middle Aged; Necrosis; Skin Diseases	1965