acenocoumarol and Seizures

acenocoumarol has been researched along with Seizures* in 2 studies

Other Studies

2 other study(ies) available for acenocoumarol and Seizures

Article	Year
[Anesthesia in a patient with homocystinuria and severe pulmonary embolism]. Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:3 Topics: Acenocoumarol; Aggression; Anesthesia, General; Anesthetics; Anticoagulants; Contraindications; Enoxaparin; Hemodynamics; Homocystinuria; Humans; Hypoglycemia; Hypoxia; Intraoperative Complications; Male; Nitrous Oxide; Pulmonary Embolism; Seizures; Thrombophilia; Vena Cava Filters; Venous Thrombosis; Young Adult	2009
Acenocoumarol and phenytoin toxicity in the presence of CYP2C9 mutation. The Journal of the Association of Physicians of India, 2008, Volume: 56 This case report describes a rare interaction between therapeutic doses of phenytoin and acenocoumarol resulting in both acute phenytoin toxicity and increased international normalized ratio (INR). Interactions between these drugs are due to the pharmacokinetics and the common metabolising pathway by hepatic cytochrome P450 isoenzyme-CYP2C9. Our patient was detected to be homozygous for CYP2C9*3 by PCR-RFLP analysis resulting in markedly decreased metabolism of both the drugs. Given that these two drugs are often given concomitantly in the medical out patient department, and that CYP2C9 polymorphisms are not uncommon, clinicians should be aware of this interaction and suspect this in patients with toxicity to these drugs. Topics: Acenocoumarol; Adult; Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Drug Interactions; Female; Humans; Mutation; Pharmacogenetics; Phenytoin; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Seizures	2008

Article

Year

[Anesthesia in a patient with homocystinuria and severe pulmonary embolism].

Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:3

Topics: Acenocoumarol; Aggression; Anesthesia, General; Anesthetics; Anticoagulants; Contraindications; Enoxaparin; Hemodynamics; Homocystinuria; Humans; Hypoglycemia; Hypoxia; Intraoperative Complications; Male; Nitrous Oxide; Pulmonary Embolism; Seizures; Thrombophilia; Vena Cava Filters; Venous Thrombosis; Young Adult

2009

Acenocoumarol and phenytoin toxicity in the presence of CYP2C9 mutation.

The Journal of the Association of Physicians of India, 2008, Volume: 56

This case report describes a rare interaction between therapeutic doses of phenytoin and acenocoumarol resulting in both acute phenytoin toxicity and increased international normalized ratio (INR). Interactions between these drugs are due to the pharmacokinetics and the common metabolising pathway by hepatic cytochrome P450 isoenzyme-CYP2C9. Our patient was detected to be homozygous for CYP2C9*3 by PCR-RFLP analysis resulting in markedly decreased metabolism of both the drugs. Given that these two drugs are often given concomitantly in the medical out patient department, and that CYP2C9 polymorphisms are not uncommon, clinicians should be aware of this interaction and suspect this in patients with toxicity to these drugs.

Topics: Acenocoumarol; Adult; Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Drug Interactions; Female; Humans; Mutation; Pharmacogenetics; Phenytoin; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Seizures

2008