acenocoumarol and Peptic-Ulcer

acenocoumarol has been researched along with Peptic-Ulcer* in 2 studies

Trials

1 trial(s) available for acenocoumarol and Peptic-Ulcer

ArticleYear
Pharmacokinetics of low molecular weight dermatan sulphate (desmin) in different cohorts of patients.
    Thrombosis research, 1998, May-01, Volume: 90, Issue:3

    Topics: Acenocoumarol; Adult; Cholestasis; Chromogenic Compounds; Cohort Studies; Desmin; Factor Xa; Humans; Liver Diseases; Middle Aged; Partial Thromboplastin Time; Peptic Ulcer; Prothrombin; Thrombin Time; Thrombosis

1998

Other Studies

1 other study(ies) available for acenocoumarol and Peptic-Ulcer

ArticleYear
Lack of effect of omeprazole in oral acenocoumarol anticoagulant therapy.
    Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:10

    Omeprazole is eliminated almost completely by hepatic metabolism within the cytochrome P-450 system and might inhibit the oxidative metabolism of other drugs. This is particularly relevant for compounds with a narrow therapeutic range, such as acenocoumarol. In this study we evaluated the effect of omeprazole use in patients receiving continuous acenocoumarol therapy.. One thousand and fifty-seven patients receiving long-term oral acenocoumarol combined with omeprazole were selected retrospectively. In 118 of these patients omeprazole was considered the only factor of possible influence on anticoagulant therapy. The control group consisted of 299 age- and sex-matched patients taking acenocoumarol without interfering medication. Dose adjustment of acenocoumarol on starting omeprazole therapy was indicated by clinically relevant changes in coagulation time.. No adaptation of the anticoagulant dose was necessary in 74 of 118 omeprazole patients (62.7%), compared with 169 of 299 controls (56.5%). A higher dose was necessary in 30 of 118 omeprazole patients (25.4%), compared with 84 of 299 controls (28.0%). In 14 of 118 omeprazole patients (11.9%) a lowering of the anticoagulant dose was required, compared with 46 of 299 controls (15.4%).. We found no evidence of any interaction between omeprazole and acenocoumarol. It seems likely that omeprazole can be administered safely to patients treated with acenocoumarol.

    Topics: Acenocoumarol; Administration, Oral; Aged; Anti-Ulcer Agents; Anticoagulants; Case-Control Studies; Drug Interactions; Female; Humans; Liver; Male; Omeprazole; Peptic Ulcer; Retrospective Studies

1997