acenocoumarol and Lung-Neoplasms

Acquired haemophilia A is a rare disorder caused by spontaneous formation of auto-antibodies (inhibitors) against coagulation factor VIII. This can lead tolife-threatening haemorrhages. Six to twenty-two percent of patients with acquired haemophilia have an underlying malignancy. We describe a 69-year-old woman with metastatic breast cancer and non-small cell lung carcinoma who presented at the emergency room with spontaneous bruising, and who was using a vitamin K antagonist. She had a prolonged activated partial thromboplastin time (aPTT) due to a coagulation factor VIII deficiency caused by factor VIII antibodies. She was treated with prednisone and cyclophosphamide.

Topics: Acenocoumarol; Aged; Anticoagulants; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Hemophilia A; Humans; Lung Neoplasms

Drug interactions can cause many clinical problems, particularly when the drugs are administered in combination with anticancer agents.. A patient required two hospitalizations due to risk of bleeding with altered INR probably due to an interaction between gefitinib and acenocoumarol, which resulted in the potentiation of the effect of the latter and acenocoumarol dose adjustment was needed. A causality assessment between the drug-drug interaction and the augmented INR was conducted according to Naranjo algorithm and was classified as a definite adverse drug reaction.. Patient's management recommended is to closely monitor for changes in the effects of coumarin derivatives, if administered concomitantly with antineoplasic agents.

Topics: Acenocoumarol; Adenocarcinoma; Aged; Anticoagulants; Antineoplastic Agents; Atrial Fibrillation; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Gefitinib; Heart Failure; Humans; International Normalized Ratio; Lung Neoplasms; Male; Protein Kinase Inhibitors; Quinazolines

Bleeding into the lung parenchyma is a rare phenomenon that usually occurs as a result of chest trauma, other causes are anticoagulant therapy, and infections. The following case presents a patient admitted to the hospital due to haemoptysis, which was a symptom of bleeding into the emphysematosus bulla caused by anticoagulation therapy. The decisive diagnostic examination was chest magnetic resonance. This imaging method allows the precise differentiation of tissues. Using modern imaging techniques can often dispense with invasive diagnostic methods.

Topics: Acenocoumarol; Anticoagulants; Blister; Diagnosis, Differential; Emphysema; Hemoptysis; Hemorrhage; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Tuberculosis, Pulmonary

We report a case of a 53-year-old male who presented with thoracodynia three months after right pneumonectomy. Chest CT-scan demonstrated thrombus at the pulmonary artery stump without any other abnormal finding. He was treated successfully with acenocoumarol. We present this case analyzing the possible causes and discussing the treatment.

Topics: Acenocoumarol; Anticoagulants; Carcinoma, Non-Small-Cell Lung; Humans; Ligation; Lung Neoplasms; Male; Middle Aged; Pneumonectomy; Pulmonary Artery; Pulmonary Embolism; Thrombosis; Tomography, X-Ray Computed

In this study we presented the case of 55 years old man who was admitted to the Dept. of Lung Diseases and Tuberculosis in Zabrze with haemoptysis, dyspnoea, fever and lung infiltration. Initially the neoplastic disease was diagnosed. From the information gathered from the patient's family it was stated that the patient has been taking acenocoumarol for a considerably long time without any professional supervision. In this study we emphasize the importance of motivating and informing patients about the purposefulness of control examinations while using this kind of drugs.

Topics: Acenocoumarol; Anticoagulants; Autopsy; Dyspnea; Fatal Outcome; Fever; Hemoptysis; Humans; Lung Diseases; Lung Neoplasms; Male; Middle Aged

Effect of peritoneal cells (PC) from mice treated with a combination of drugs (indomethacin, poly I:C and Syncumar) on the take of Lewis lung (LL) carcinoma was studied in Winn-type adoptive transfer experiments. Transfer of PC from mice given a single intraperitoneal injection of polyinosinic-polycytidylic acid (poly I:C) or indomethacine or Syncumar (100 micrograms of each) per se did not suppress the take of Lewis lung carcinoma in the recipient mice. PC obtained from mice treated with a combination of indomethacin and poly I:C or poly I:C and Syncumar also failed to inhibit the take of the tumour. In contrast, PC collected from mice after a combined treatment with the three drugs (indomethacin + poly I:C + Syncumar) resulted in a 30-60% decrease in tumour take depending on the tumour cell/PC ratio. This effect could not be observed when a single intraperitoneal dose of cyclophosphamide was administered three days before starting of the combined treatment of the donor mice. The effector cells contributing to the tumour inhibitory effect proved to be nonadherent cells, probably large granular lymphocytes (LGL), as their suppressive effect was abrogated after treatment with the lysosomotrop vital dye neutral red.

Topics: Acenocoumarol; Animals; Cell Adhesion; Cyclophosphamide; Female; Immunization, Passive; Indomethacin; Lung Neoplasms; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neutral Red; Peritoneal Cavity; Poly I-C

Topics: Acenocoumarol; Aminocaproates; Animals; Blood Coagulation; Female; Lung Neoplasms; Male; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Cells, Circulating; Rats; Sarcoma, Yoshida; Time Factors