acenocoumarol and Hip-Fractures

The effect of either (randomized) Heparin/Dihydroergotamine (HDHE) or heparin-acenocoumarin (Hep/S) on the incidence of deep-vein thrombosis in the legs was studied in 212 women of more than 60 years of age with hip fractures. All patients were screened with the 125-I-fibrinogen uptake test (FUT) confirmed by a bilateral ascending venogram upon positive FUT. This revealed good sensitivity and specificity (85/84%) for the FUT. Deep vein thrombosis developed in 37.6% of the HDHE group and in 59.1% of the Hep/S group which was significantly different (p less than 0.005). The calculated thrombosis risk was significantly diminished (by 38% - p less than 0.005) in the HDHE group. Therefore we conclude that in traumatology Heparin/Dihydroergotamine seems to be the prophylaxis of choice.

Topics: Acenocoumarol; Aged; Aged, 80 and over; Anticoagulants; Bone Nails; Dihydroergotamine; Drug Therapy, Combination; Female; Heparin; Hip Fractures; Humans; Middle Aged; Thrombosis

The effect of either (randomized) Heparin/Dihydroergotamine (HDHE) or heparin-acenocoumarin (Hep/S) on the incidence of deep-vein thrombosis in the legs was studied in 212 women of more than 60 years of age with hip fractures. All patients were screened with the 125-I-fibrinogen uptake test (FUT) confirmed by a bilateral ascending venogram upon positive FUT. This revealed good sensitivity and specificity (85/84%) for the FUT. Deep vein thrombosis developed in 37.6% of the HDHE group and in 59.1% of the Hep/S group which was significantly different (p less than 0.005). The calculated thrombosis risk was significantly diminished (by 38% - p less than 0.005) in the HDHE group. Therefore we conclude that in traumatology Heparin/Dihydroergotamine seems to be the prophylaxis of choice.

Topics: Acenocoumarol; Aged; Aged, 80 and over; Anticoagulants; Bone Nails; Dihydroergotamine; Drug Therapy, Combination; Female; Heparin; Hip Fractures; Humans; Middle Aged; Thrombosis

The effect of either heparin-dihydergot or heparin-acenocoumarin on the incidence of deep-vein thrombosis in the legs was studied in 181 women undergoing Ender nailing for intertrochanteric fracture of the femur. All the patients were screened with the 125-I-fibrinogen uptake test, confirmed by a bilateral ascending venogram. Deep-vein thrombosis developed in 40 per cent of the heparin-dihydergot group and in 61 per cent of the heparin-acenocoumarin group (p less than 0.015).

Topics: Acenocoumarol; Aged; Aged, 80 and over; Bone Nails; Dihydroergotamine; Drug Evaluation; Drug Therapy, Combination; Female; Fibrinogen; Heparin; Hip Fractures; Humans; Iodine Radioisotopes; Iothalamate Meglumine; Middle Aged; Radiography; Radionuclide Imaging; Random Allocation; Thromboembolism; Time Factors