acenocoumarol and Headache

Topics: Acenocoumarol; Adult; Anticoagulants; Cerebral Angiography; Cerebral Infarction; Epilepsies, Partial; Fatal Outcome; Genetic Predisposition to Disease; Headache; Heparin; Heparin, Low-Molecular-Weight; Humans; Hydrocephalus; Male; Recurrence; Sinus Thrombosis, Intracranial; Ventriculoperitoneal Shunt

A 42-year-old man presented with ptosis and miosis in his left eye and a history of headache over the last 20 days. An angioresonance showed dissection of internal carotid artery.. "Painful Horner's Syndrome" is considered to be a medical emergency due possible onset of an internal carotid artery dissection. We consider that awareness of neuro-ophthalmologic emergencies is very important in the clinical praxis of an ophthalmologist. Multidisciplinary treatment and follow-up of these patients is required.

Topics: Acenocoumarol; Adult; Analgesics; Anticoagulants; Antihypertensive Agents; Bed Rest; Blepharoptosis; Carotid Artery Thrombosis; Carotid Artery, Internal, Dissection; Combined Modality Therapy; Headache; Horner Syndrome; Humans; Hypertension; Magnetic Resonance Angiography; Male

The aim of our study was to investigate the possible effect of acenocoumarol, which is indicated for nonneurological disease, on headache.. It has been suggested that anticoagulation can have beneficial effects in the control of migraine attacks.. Four hundred randomized patients on oral anticoagulant therapy were asked to complete a questionnaire regarding their headaches.. Headache was present before or during oral anticoagulation in 166 (66 migraineurs and 100 nonmigraineurs) of 326 respondents. The major finding was that oral anticoagulation produced improvement in 63% of patients with migraine versus 38% of patients with nonmigranous headache. Improvement was related to the severity of migraine but not to age.. Oral anticoagulant therapy can improve migraine. The way in which anticoagulant therapy acts on migraine is unknown, but potential mechanisms include its effect on platelet aggregability and pharmacological effects such as suppression of enhanced nitric oxide.

Topics: Acenocoumarol; Adult; Aged; Aged, 80 and over; Anticoagulants; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Random Allocation; Retrospective Studies; Surveys and Questionnaires

Topics: Acenocoumarol; Adult; Anticoagulants; Blood Coagulation Disorders; Cardiovascular System; Drug Overdose; Female; Headache; Humans; Male; Middle Aged; Urticaria; Vitamin E