acenocoumarol and Genital-Diseases--Female

The antithromboembolic efficacy of once a day low molecular weight heparin in fixed combination with dihydroergotamine (LMWH-DHE) was compared with conventional heparin-DHE in combination with Acenocoumarol (heparin-DHE/A) in 191 patients undergoing gynaecological surgery. LMWH-DHE proved equally effective in preventing thromboembolic complications, with a similar incidence of postoperative bleeding and side effects. Deep vein thrombosis occurred once in each group and one non-fatal pulmonary embolism occurred in the LMWH-DHE group. The main advantage of LMWH-DHE was significantly better patient acceptance of the single daily subcutaneous injection as compared with the two injections of conventional heparin-DHE (P = 0.02). On the other hand, LMWH-DHE was associated with significantly increased incidence of intraoperative bleeding (P less than 0.02). The bleeding did not, however, cause any clinical problems. Discontinuation of therapy due to bleeding or pain at the site of injection occurred three times in each group. We consider the use of LMWH-DHE to be an attractive, economic and safe method of thromboembolic prophylaxis.

Topics: Acenocoumarol; Clinical Trials as Topic; Dihydroergotamine; Drug Combinations; Female; Genital Diseases, Female; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Humans; Hysterectomy; Postoperative Complications; Premedication; Prospective Studies; Pulmonary Embolism; Random Allocation; Thrombophlebitis

Topics: Acenocoumarol; Cesarean Section; Clinical Trials as Topic; Dextrans; Female; Genital Diseases, Female; Humans; Leg; Obstetric Labor Complications; Oxyphenbutazone; Phlebitis; Postoperative Complications; Pregnancy; Pulmonary Embolism; Thromboembolism; Thrombophlebitis

Topics: Acenocoumarol; Adult; Clinical Trials as Topic; Female; Genital Diseases, Female; Humans; Pregnancy; Pregnancy Complications; Puerperal Disorders; Thrombosis

Topics: Acenocoumarol; Adult; Blood Coagulation Tests; Cesarean Section; Female; Genital Diseases, Female; Genital Neoplasms, Female; Heparin; Humans; Hysterectomy; Middle Aged; Postoperative Care; Postoperative Complications; Pregnancy; Thromboembolism; Thrombosis

Topics: Acenocoumarol; Adult; Aged; Cesarean Section; Female; Genital Diseases, Female; Humans; Hysterectomy; Middle Aged; Pregnancy; Preoperative Care; Thromboembolism; Thrombosis

Topics: Acenocoumarol; Anticoagulants; Female; Genital Diseases, Female; Gynecologic Surgical Procedures; Humans; Postoperative Care; Surgical Procedures, Operative; Thromboembolism

Topics: Acenocoumarol; Analgesia; Anesthesia; Anesthesia and Analgesia; Anticoagulants; Coumarins; Female; Genital Diseases, Female; Gynecology; Humans; Labor, Obstetric; Obstetrics; Pain Management; Pregnancy