acenocoumarol and Diabetes-Mellitus--Type-2

Vitamin K antagonists are widely used in thromboembolic diseases. Hemorrhagic complications related to drug overdose represent their main side effect. We report a rare side effect, a severe and unexpected type of skin vasculitis - necrotic leg ulcer - induced by vitamin K antagonist.. A 63-year-old female with a history of diabetes developed hyperalgesic necrotic ulcerations on the lower limbs one month after starting an acenocoumarol-based treatment for ischemic heart disease. Histological examination revealed lymphocytic vasculitis with fibrinoid necrosis. Etiological explorations searching for vasculitis were negative. In the absence of a precise etiology, drug-induced ulcer was suspected. Low molecular weight heparin was prescribed to replace acenocoumarol. The lesions slowly resolved with topical treatment.. The chronological criteria and the negativity of etiological explorations allowed the diagnosis of vitamin K antagonist-induced necrotic skin ulcer. Clinicians should be aware of this rare complication induced by oral anticoagulants because of its practical therapeutic implications. This is the first case of necrotic leg ulcer induced by acenocoumarol corresponding histologically to necrotising lymphocytic vasculitis.

Topics: Acenocoumarol; Anticoagulants; Diabetes Mellitus, Type 2; Drug Substitution; Female; Heparin, Low-Molecular-Weight; Humans; Hyperalgesia; Leg Ulcer; Middle Aged; Necrosis; Vasculitis; Vitamin K

Although traditionally observed in patients with end-stage renal disease and secondary hyperparathyroidism, calciphylaxis has been reported in patients with normal renal and parathyroid function. There is no evidence-based therapy available. The use of sodium thiosulfate (STS) has been increasingly described. Herein we describe two patients who responded well to this treatment.

Topics: Acenocoumarol; Aged; Aged, 80 and over; Atrial Fibrillation; Calciphylaxis; Comorbidity; Diabetes Mellitus, Type 2; Drug Substitution; Female; Heparin, Low-Molecular-Weight; Humans; Hyperparathyroidism, Secondary; Livedo Reticularis; Obesity; Peripheral Vascular Diseases; Risk Factors; Shock, Septic; Thiosulfates; Urinary Tract Infections; Vitamin D Deficiency

Topics: Acenocoumarol; Acidosis, Lactic; Anticoagulants; Aortic Valve Stenosis; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Type 2; Drug Interactions; Female; Heart Valve Prosthesis Implantation; Humans; Hypoglycemic Agents; Lactones; Metformin; Middle Aged; Prothrombin Time; Sulfones