acenocoumarol and Arteriolosclerosis

A 63-year-old woman was referred to the dermatology outpatient department with extremely painful ulcers on the right lower leg. Medical history listed hypertension, diabetes mellitus and chronic obstructive pulmonary disease. Intensive analgesia was insufficient. Blood analysis, microbial cultures and venous ultrasound did not reveal a cause. At histopathologic examination of an ulcer, arteriolosclerosis was revealed. The patient was treated for Martorell arteriolosclerotic ulcer with nifedipine, acenocoumarol and split-thickness skin grafts followed by vacuum-assisted closure therapy. Two weeks postoperative, analgesia was discontinued and all ulcers were healed. Nifedipine and acenocoumarol were continued in the outpatient setting to prevent relapses. Patients with long-standing hypertension are particularly prone to cutaneous arteriolosclerosis. Thrombosis of the cutaneous arterioles results in painful ischemic ulcers. This disease probably frequently goes unrecognised.

Topics: Acenocoumarol; Arteriolosclerosis; Combined Modality Therapy; Diagnosis, Differential; Female; Humans; Leg Ulcer; Middle Aged; Nifedipine; Skin Transplantation; Treatment Outcome