acemetacin has been researched along with Arthritis, Rheumatoid in 17 studies
acemetacin : A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activity is due to both acemetacin and its major metabolite, indometacin.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multi-centre, double-blind, randomized parallel group study was undertaken in general practice to compare the efficacy and tolerability of the new non-steroidal anti-inflammatory drug acemetacin with indomethacin in patients suffering from rheumatoid arthritis." | 9.07 | Acemetacin and indomethacin in the treatment of rheumatoid arthritis: a double-blind comparative study in general practice. ( Korlipara, K; Saul, PA, 1991) |
| "An open, multi-centre trial was carried out to assess the efficacy and tolerance of acemetacin in the treatment of patients suffering from various rheumatic diseases." | 9.05 | Acemetacin in the treatment of rheumatic diseases: an open, multi-centre trial. ( Rechziegler, H; Zündorf, P, 1985) |
| "An open label study was carried out to assess the long-term use of acemetacin in patients suffering from rheumatoid arthritis." | 7.68 | Acemetacin in the long-term therapy of rheumatoid arthritis. ( Bernstein, RM; Hazleman, B, 1993) |
| "Within the framework of a long-term study the efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) were tested in 26 female patients suffering from rheumatoid arthritis." | 7.66 | [Results of a long-term study with acemetacin in the therapy of patients suffering from rheumatoid arthritis (author's transl)]. ( Eberl, R; Heiter, A; Tausch, G, 1980) |
| "A multi-centre, double-blind, randomized parallel group study was undertaken in general practice to compare the efficacy and tolerability of the new non-steroidal anti-inflammatory drug acemetacin with indomethacin in patients suffering from rheumatoid arthritis." | 5.07 | Acemetacin and indomethacin in the treatment of rheumatoid arthritis: a double-blind comparative study in general practice. ( Korlipara, K; Saul, PA, 1991) |
| "In a double blind study [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil¿) was compared with indometacin in 2 x 20 patients suffering from rheumatoid arthritis." | 5.05 | [Controlled double blind comparison of acemetacin to indomethacin in patients with chronic polyarthritis]. ( Eberl, R; Heiter, A; Tausch, G, 1980) |
| "In a controlled double blind study the therapeutic efficacy and tolerability of equimolar doses of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) and indometacin (acemetacin: 180 mg/day, indometacin: 150 mg/day) were studied in 40 patients suffering from rheumatoid arthritis." | 5.05 | [Treatment of chronic polyarthritis with acemetacin and indomethacin]. ( Badia-Flores, J; Muñoz Barradas, F, 1980) |
| "An open, multi-centre trial was carried out to assess the efficacy and tolerance of acemetacin in the treatment of patients suffering from various rheumatic diseases." | 5.05 | Acemetacin in the treatment of rheumatic diseases: an open, multi-centre trial. ( Rechziegler, H; Zündorf, P, 1985) |
| "An open label study was carried out to assess the long-term use of acemetacin in patients suffering from rheumatoid arthritis." | 3.68 | Acemetacin in the long-term therapy of rheumatoid arthritis. ( Bernstein, RM; Hazleman, B, 1993) |
| "The dose-reducing effect of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy[ acetic acid (acemetacin, TV 1322, Rantudil¿) on prednisolon was studied on 22 patients suffering from rheumatoid arthritis." | 3.66 | [Study of the dose-reducing effect of acemetacin on prednisolon (author's transl)]. ( Mathies, H; Wolff, E, 1980) |
| "Within the framework of a long-term study the efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) were tested in 26 female patients suffering from rheumatoid arthritis." | 3.66 | [Results of a long-term study with acemetacin in the therapy of patients suffering from rheumatoid arthritis (author's transl)]. ( Eberl, R; Heiter, A; Tausch, G, 1980) |
| " After a steady-state has been reached half-life of elimination is 4." | 2.65 | [Metabolism and pharmacokinetics of acemetacin in man (author's transl)]. ( Dell, HD; Doersing, M; Fischer, W; Jacobi, H; Kamp, R; Köhler, G; Schöllnhammer, G, 1980) |
| " The dosage has to be established individually for each patient because the resorption is independent from body size and body weight." | 1.26 | [Distribution of non-steroidal anti-inflammatory agents in human tissues]. ( Köhler, G, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mizushima, Y | 1 |
| Uthgenannt, H | 1 |
| Mohing, W | 1 |
| Köhler, G | 3 |
| Schmidt, F | 1 |
| Havemann, R | 1 |
| Dell, HD | 2 |
| Doersing, M | 1 |
| Fischer, W | 1 |
| Jacobi, H | 1 |
| Kamp, R | 1 |
| Schöllnhammer, G | 1 |
| Tuschl, P | 1 |
| Wottawa, A | 1 |
| Heiter, A | 3 |
| Tausch, G | 3 |
| Eberl, R | 2 |
| Badia-Flores, J | 1 |
| Muñoz Barradas, F | 1 |
| Mathies, H | 1 |
| Wolff, E | 1 |
| Blumberger, W | 1 |
| Rechziegler, H | 2 |
| Spechtmeyer, H | 1 |
| Hazleman, B | 1 |
| Bernstein, RM | 1 |
| Kullich, W | 1 |
| Klein, G | 1 |
| Saul, PA | 1 |
| Korlipara, K | 1 |
| Gospodinoff, A | 1 |
| Fiore, L | 1 |
| Dardano, B | 1 |
| Fiore, D | 1 |
| Scapato, P | 1 |
| Seissiger, L | 1 |
| Zündorf, P | 1 |
7 trials available for acemetacin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Pro-drugs of non-steroidal anti-inflammatory agents.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Gast | 1983 |
[The influence of acemetacin and indometacin on gastrointestinal blood loss in normal volunteers and rheumatic patients (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Double-Blind Method; Gastrointestinal | 1980 |
[Metabolism and pharmacokinetics of acemetacin in man (author's transl)].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Biological Availability; Biotransformation; Female; | 1980 |
[Controlled double blind comparison of acemetacin to indomethacin in patients with chronic polyarthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Double-Blind Method; | 1980 |
[Treatment of chronic polyarthritis with acemetacin and indomethacin].
Topics: Adult; Aged; Aging; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Double-Blind M | 1980 |
Acemetacin and indomethacin in the treatment of rheumatoid arthritis: a double-blind comparative study in general practice.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Fe | 1991 |
Acemetacin in the treatment of rheumatic diseases: an open, multi-centre trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Clinical Tri | 1985 |
10 other studies available for acemetacin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Distribution of non-steroidal anti-inflammatory agents in human tissues].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Indoleacetic Acids; Indomethacin; Ketoprofe | 1982 |
[Influence of acemetacin on DNA repair and DNA synthesis in vitro and in vivo (author's transl)].
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cells, Cultured; DNA; DNA Rep | 1980 |
[Study of the dose-reducing effect of acemetacin on prednisolon (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Fema | 1980 |
[Results of a long-term study with acemetacin in the therapy of patients suffering from rheumatoid arthritis (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Indol | 1980 |
[Multicentre long-term study with acemetacin (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Indol | 1980 |
Acemetacin in the long-term therapy of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Respon | 1993 |
Acemetacin (Emflex)--yet another NSAID.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Half-Life; Humans; Indomethacin; Liv | 1991 |
[Changes in the serum pepsinogen level during therapy with acemtacin retard as a measure of gastroduodenal tolerance].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Delayed-Action Preparations; | 1991 |
[Open clinical study on the efficacy and tolerance of acemetacin in rheumatoid arthritis and osteoarthrosis].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Etodolac; Female; Human | 1989 |
[Acemetacin in patients with rheumatic disease with concomitant liver diseases. Pharmacokinetics, effectiveness and tolerance].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Inju | 1987 |