acemetacin has been researched along with Aging in 3 studies
acemetacin : A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activity is due to both acemetacin and its major metabolite, indometacin.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a controlled double blind study the therapeutic efficacy and tolerability of equimolar doses of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) and indometacin (acemetacin: 180 mg/day, indometacin: 150 mg/day) were studied in 40 patients suffering from rheumatoid arthritis." | 5.05 | [Treatment of chronic polyarthritis with acemetacin and indomethacin]. ( Badia-Flores, J; Muñoz Barradas, F, 1980) |
| " After dosing to steady state (7 days), the mean plasma elimination half-life for acemetacin was 1." | 1.28 | The comparative pharmacokinetics of acemetacin in young subjects and elderly patients. ( Collins, AJ; Jones, RW; Notarianni, LJ; Sedman, E, 1991) |
| "Acemetacin was tolerated better than indometacin in all cases." | 1.26 | [Toxicology of acemetacin]. ( Dell, HD; Jacobi, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jacobi, H | 1 |
| Dell, HD | 1 |
| Badia-Flores, J | 1 |
| Muñoz Barradas, F | 1 |
| Jones, RW | 1 |
| Collins, AJ | 1 |
| Notarianni, LJ | 1 |
| Sedman, E | 1 |
1 trial available for acemetacin and Aging
| Article | Year |
|---|---|
[Treatment of chronic polyarthritis with acemetacin and indomethacin].
Topics: Adult; Aged; Aging; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Double-Blind M | 1980 |
2 other studies available for acemetacin and Aging
| Article | Year |
|---|---|
[Toxicology of acemetacin].
Topics: Aging; Animals; Anti-Inflammatory Agents; Cats; Dogs; Female; Indoleacetic Acids; Indomethacin; Leth | 1980 |
The comparative pharmacokinetics of acemetacin in young subjects and elderly patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Half-Life; Humans; Indo | 1991 |