acecainide has been researched along with Ventricular Fibrillation in 7 studies
Acecainide: A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
N-acetylprocainamide : A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We analyzed the pharmacokinetic properties of PA and NAPA and elucidated their effect kinetics with a pharmacokinetic-pharmacodynamic (PK/PD) model in view of different transfer qualities." | 5.28 | [Combined pharmacokinetic-pharmacodynamic model of procainamide in rabbits with induced ventricular fibrillation threshold (VFT) changes]. ( Huang, SK; Lu, DY; Lu, H; Lu, JF; Yang, JY, 1991) |
| "Nineteen patients whose arrhythmias were initially suppressed with acetylprocainamide underwent long-term treatment with this drug." | 3.66 | Long-term antiarrhythmic therapy with acetylprocainamide. ( Drayer, DE; Kluger, J; Leech, S; Lloyd, V; Reidenberg, MM, 1981) |
| " We analyzed the pharmacokinetic properties of PA and NAPA and elucidated their effect kinetics with a pharmacokinetic-pharmacodynamic (PK/PD) model in view of different transfer qualities." | 1.28 | [Combined pharmacokinetic-pharmacodynamic model of procainamide in rabbits with induced ventricular fibrillation threshold (VFT) changes]. ( Huang, SK; Lu, DY; Lu, H; Lu, JF; Yang, JY, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kluger, J | 1 |
| Leech, S | 1 |
| Reidenberg, MM | 1 |
| Lloyd, V | 1 |
| Drayer, DE | 1 |
| Marchlinski, FE | 1 |
| Buxton, AE | 1 |
| Vassallo, JA | 1 |
| Waxman, HL | 1 |
| Cassidy, DM | 1 |
| Doherty, JU | 1 |
| Josephson, ME | 1 |
| Reynolds, RD | 1 |
| Kamath, BL | 1 |
| Brautigam, RT | 1 |
| Schuster, M | 1 |
| Porter, RS | 1 |
| Nydegger, C | 1 |
| Kutalek, SP | 1 |
| Lu, H | 1 |
| Huang, SK | 1 |
| Yang, JY | 1 |
| Lu, DY | 1 |
| Lu, JF | 1 |
| Echt, DS | 1 |
| Black, JN | 1 |
| Barbey, JT | 1 |
| Coxe, DR | 1 |
| Cato, E | 1 |
| Herre, JM | 1 |
| Thompson, JA | 1 |
1 trial available for acecainide and Ventricular Fibrillation
| Article | Year |
|---|---|
Comparison of intravenous dosing regimens for maintaining steady-state procainamide levels during programmed ventricular stimulation.
Topics: Acecainide; Cardiac Pacing, Artificial; Humans; Immunoenzyme Techniques; Infusions, Intravenous; Inj | 1992 |
6 other studies available for acecainide and Ventricular Fibrillation
| Article | Year |
|---|---|
Long-term antiarrhythmic therapy with acetylprocainamide.
Topics: Acecainide; Acetylation; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arthritis, Rheum | 1981 |
Comparative electrophysiologic effects of intravenous and oral procainamide in patients with sustained ventricular arrhythmias.
Topics: Acecainide; Administration, Oral; Adult; Aged; Cardiac Pacing, Artificial; Electrophysiology; Female | 1984 |
N-acetylprocainamide and ischemia-induced ventricular fibrillation in the dog.
Topics: Acecainide; Animals; Blood Pressure; Coronary Disease; Dogs; Electrocardiography; Female; Heart Rate | 1979 |
[Combined pharmacokinetic-pharmacodynamic model of procainamide in rabbits with induced ventricular fibrillation threshold (VFT) changes].
Topics: Acecainide; Animals; Female; Linear Models; Male; Mathematics; Procainamide; Rabbits; Ventricular Fi | 1991 |
Evaluation of antiarrhythmic drugs on defibrillation energy requirements in dogs. Sodium channel block and action potential prolongation.
Topics: Acecainide; Action Potentials; Animals; Anti-Arrhythmia Agents; Cesium; Dogs; Electric Countershock; | 1989 |
Polymorphic ventricular tachycardia and ventricular fibrillation due to N-acetyl procainamide.
Topics: Acecainide; Aged; Electrocardiography; Heart Ventricles; Humans; Male; Procainamide; Tachycardia; Ve | 1985 |