acecainide has been researched along with Atrial Flutter in 4 studies
Acecainide: A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
N-acetylprocainamide : A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.
Atrial Flutter: Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antiarrhythmic therapy for the suppression of atrial flutter has conventionally entailed the use of a class Ia agent such as quinidine or procainamide." | 9.06 | Oral N-acetylprocainamide compared to quinidine plus digoxin in the chronic suppression of atrial flutter in humans. ( Feld, GK; Nademanee, K; Noll, E; Singh, BN, 1989) |
| " The effects of NAPA (25 mg/kg intravenously) on sustained, stable, reentrant atrial flutter induced in 12 conscious dogs using a sterile pericarditis model were studied and compared with the effects of quinidine (5 mg/kg intravenously) given on a different day in 10 of the same 12 dogs." | 7.67 | Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: comparison with the effects of quinidine. ( Okumura, K; Waldo, AL, 1987) |
| "We studied the effects of procainamide and N-acetylprocainamide (NAPA) in a conscious dog preparation of atrial flutter resulting from circus movement around the tricuspid orifice." | 7.67 | Effect of procainamide and N-acetylprocainamide on atrial flutter: studies in vivo and in vitro. ( Hoffman, BF; Wu, KM, 1987) |
| "Antiarrhythmic therapy for the suppression of atrial flutter has conventionally entailed the use of a class Ia agent such as quinidine or procainamide." | 5.06 | Oral N-acetylprocainamide compared to quinidine plus digoxin in the chronic suppression of atrial flutter in humans. ( Feld, GK; Nademanee, K; Noll, E; Singh, BN, 1989) |
| " The effects of NAPA (25 mg/kg intravenously) on sustained, stable, reentrant atrial flutter induced in 12 conscious dogs using a sterile pericarditis model were studied and compared with the effects of quinidine (5 mg/kg intravenously) given on a different day in 10 of the same 12 dogs." | 3.67 | Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: comparison with the effects of quinidine. ( Okumura, K; Waldo, AL, 1987) |
| "We studied the effects of procainamide and N-acetylprocainamide (NAPA) in a conscious dog preparation of atrial flutter resulting from circus movement around the tricuspid orifice." | 3.67 | Effect of procainamide and N-acetylprocainamide on atrial flutter: studies in vivo and in vitro. ( Hoffman, BF; Wu, KM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okumura, K | 1 |
| Waldo, AL | 1 |
| Wu, KM | 1 |
| Hoffman, BF | 1 |
| Feld, GK | 2 |
| Venkatesh, N | 1 |
| Singh, BN | 2 |
| Nademanee, K | 1 |
| Noll, E | 1 |
1 trial available for acecainide and Atrial Flutter
| Article | Year |
|---|---|
Oral N-acetylprocainamide compared to quinidine plus digoxin in the chronic suppression of atrial flutter in humans.
Topics: Acecainide; Action Potentials; Aged; Atrial Flutter; Digoxin; Drug Therapy, Combination; Humans; Mal | 1989 |
3 other studies available for acecainide and Atrial Flutter
| Article | Year |
|---|---|
Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: comparison with the effects of quinidine.
Topics: Acecainide; Animals; Atrial Flutter; Consciousness; Differential Threshold; Dogs; Electrophysiology; | 1987 |
Effect of procainamide and N-acetylprocainamide on atrial flutter: studies in vivo and in vitro.
Topics: Acecainide; Action Potentials; Animals; Atrial Flutter; Dogs; Electrocardiography; Humans; In Vitro | 1987 |
Effects of N-acetylprocainamide and recainam in the pharmacologic conversion and suppression of experimental canine atrial flutter: significance of changes in refractoriness and conduction.
Topics: Acecainide; Anesthesia; Animals; Anti-Arrhythmia Agents; Atrial Flutter; Dogs; Electrocardiography; | 1988 |