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acecainide and Aging

acecainide has been researched along with Aging in 5 studies

Acecainide: A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
N-acetylprocainamide : A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Twenty Caucasian adult patients with ventricular tachycardia were treated with intravenous procainamide."7.67Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations. ( Bauer, LA; Black, D; Gensler, A; Sprinkle, J, 1989)
" Thus, the dosage of procainamide must be individualized for both overall renal function (GFR) and the age-related variations in renal tubular secretion that are of most note in children and the elderly."5.26Aging and renal clearance of procainamide and acetylprocainamide. ( Camacho, M; Drayer, DE; Kluger, J; Reidenberg, MM, 1980)
"Twenty Caucasian adult patients with ventricular tachycardia were treated with intravenous procainamide."3.67Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations. ( Bauer, LA; Black, D; Gensler, A; Sprinkle, J, 1989)
"Procainamide hydrochloride is a Class 1A antiarrhythmic agent administered intravenously or orally for treatment of symptomatic ventricular premature depolarizations (VPD), nonsustained ventricular tachycardia, and life-threatening ventricular arrhythmias."1.30Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets. ( Abel, RB; de Vries, TM; Eldon, MA; Koup, JR; Smithers, JA, 1998)
"Lidocaine's effect was assessed alone and then when given in combination with N-acetylprocainamide, a Class III antiarrhythmic agent."1.28Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide. ( Clarkson, CW; Dise, TL; Pickoff, AS; Stolfi, A, 1991)
" At 3, 6, and 12 months of age, the half-life values of N-acetylprocainamide were 1."1.27Age-related pharmacokinetics of N-acetylprocainamide in rats. ( Kamath, BL; Lai, CM; Look, ZM; Stampfli, HF; Yacobi, A, 1983)
" Thus, the dosage of procainamide must be individualized for both overall renal function (GFR) and the age-related variations in renal tubular secretion that are of most note in children and the elderly."1.26Aging and renal clearance of procainamide and acetylprocainamide. ( Camacho, M; Drayer, DE; Kluger, J; Reidenberg, MM, 1980)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Reidenberg, MM1
Camacho, M1
Kluger, J1
Drayer, DE1
Yacobi, A1
Kamath, BL1
Stampfli, HF1
Look, ZM1
Lai, CM1
Koup, JR1
Abel, RB1
Smithers, JA1
Eldon, MA1
de Vries, TM1
Dise, TL1
Stolfi, A1
Clarkson, CW1
Pickoff, AS1
Bauer, LA1
Black, D1
Gensler, A1
Sprinkle, J1

Other Studies

5 other studies available for acecainide and Aging

ArticleYear
Aging and renal clearance of procainamide and acetylprocainamide.
    Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:6

    Topics: Acecainide; Adult; Aged; Aging; Child; Creatinine; Humans; Metabolic Clearance Rate; Middle Aged; Pr

1980
Age-related pharmacokinetics of N-acetylprocainamide in rats.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:7

    Topics: Acecainide; Administration, Oral; Aging; Animals; Injections, Intravenous; Kinetics; Procainamide; R

1983
Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets.
    Therapeutic drug monitoring, 1998, Volume: 20, Issue:1

    Topics: Acecainide; Administration, Oral; Adult; Aged; Aging; Anti-Arrhythmia Agents; Asian People; Black Pe

1998
Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Acecainide; Aging; Animals; Animals, Newborn; Atrial Function; Bundle of His; Dogs; Drug Synergism;

1991
Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:5

    Topics: Acecainide; Aged; Aging; Creatinine; Female; Heart Failure; Humans; Kidney; Kidney Diseases; Male; M

1989