acecainide and Aging
acecainide has been researched along with Aging in 5 studies
Acecainide: A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
N-acetylprocainamide : A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty Caucasian adult patients with ventricular tachycardia were treated with intravenous procainamide." | 7.67 | Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations. ( Bauer, LA; Black, D; Gensler, A; Sprinkle, J, 1989) |
| " Thus, the dosage of procainamide must be individualized for both overall renal function (GFR) and the age-related variations in renal tubular secretion that are of most note in children and the elderly." | 5.26 | Aging and renal clearance of procainamide and acetylprocainamide. ( Camacho, M; Drayer, DE; Kluger, J; Reidenberg, MM, 1980) |
| "Twenty Caucasian adult patients with ventricular tachycardia were treated with intravenous procainamide." | 3.67 | Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations. ( Bauer, LA; Black, D; Gensler, A; Sprinkle, J, 1989) |
| "Procainamide hydrochloride is a Class 1A antiarrhythmic agent administered intravenously or orally for treatment of symptomatic ventricular premature depolarizations (VPD), nonsustained ventricular tachycardia, and life-threatening ventricular arrhythmias." | 1.30 | Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets. ( Abel, RB; de Vries, TM; Eldon, MA; Koup, JR; Smithers, JA, 1998) |
| "Lidocaine's effect was assessed alone and then when given in combination with N-acetylprocainamide, a Class III antiarrhythmic agent." | 1.28 | Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide. ( Clarkson, CW; Dise, TL; Pickoff, AS; Stolfi, A, 1991) |
| " At 3, 6, and 12 months of age, the half-life values of N-acetylprocainamide were 1." | 1.27 | Age-related pharmacokinetics of N-acetylprocainamide in rats. ( Kamath, BL; Lai, CM; Look, ZM; Stampfli, HF; Yacobi, A, 1983) |
| " Thus, the dosage of procainamide must be individualized for both overall renal function (GFR) and the age-related variations in renal tubular secretion that are of most note in children and the elderly." | 1.26 | Aging and renal clearance of procainamide and acetylprocainamide. ( Camacho, M; Drayer, DE; Kluger, J; Reidenberg, MM, 1980) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Reidenberg, MM | 1 |
| Camacho, M | 1 |
| Kluger, J | 1 |
| Drayer, DE | 1 |
| Yacobi, A | 1 |
| Kamath, BL | 1 |
| Stampfli, HF | 1 |
| Look, ZM | 1 |
| Lai, CM | 1 |
| Koup, JR | 1 |
| Abel, RB | 1 |
| Smithers, JA | 1 |
| Eldon, MA | 1 |
| de Vries, TM | 1 |
| Dise, TL | 1 |
| Stolfi, A | 1 |
| Clarkson, CW | 1 |
| Pickoff, AS | 1 |
| Bauer, LA | 1 |
| Black, D | 1 |
| Gensler, A | 1 |
| Sprinkle, J | 1 |
Other Studies
5 other studies available for acecainide and Aging
| Article | Year |
|---|---|
Aging and renal clearance of procainamide and acetylprocainamide.
Topics: Acecainide; Adult; Aged; Aging; Child; Creatinine; Humans; Metabolic Clearance Rate; Middle Aged; Pr | 1980 |
Age-related pharmacokinetics of N-acetylprocainamide in rats.
Topics: Acecainide; Administration, Oral; Aging; Animals; Injections, Intravenous; Kinetics; Procainamide; R | 1983 |
Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets.
Topics: Acecainide; Administration, Oral; Adult; Aged; Aging; Anti-Arrhythmia Agents; Asian People; Black Pe | 1998 |
Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide.
Topics: Acecainide; Aging; Animals; Animals, Newborn; Atrial Function; Bundle of His; Dogs; Drug Synergism; | 1991 |
Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations.
Topics: Acecainide; Aged; Aging; Creatinine; Female; Heart Failure; Humans; Kidney; Kidney Diseases; Male; M | 1989 |