acarviosine and Hyperglycemia

acarviosine has been researched along with Hyperglycemia* in 1 studies

Other Studies

1 other study(ies) available for acarviosine and Hyperglycemia

Article	Year
Acarviosine-simmondsin, a novel compound obtained from acarviosine-glucose and simmondsin by Thermus maltogenic amylase and its in vivo effect on food intake and hyperglycemia. Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:3 Simmondsin was modified with acarviosine-glucose using the transglycosylation activity of Thermus maltogenic amylase to synthesize a novel compound with both antiobesity and hypoglycemic activity. The LC/MS and 13C NMR analyses confirmed that the structure of the major transglycosylation product was acarviosine-simmondsin (Acv-simmondsin), in which acarviosine was attached to the glucose moiety of simmondsin by an alpha-(1,6)-glycosidic linkage. It was found that Acv-simmondsin was a potent competitive inhibitor of alpha-glucosidase with the Ki value of 0.69 microM and a mixed type inhibitor of alpha-amylase with the Ki and KI of 20.78 microM and 26.31 microM, respectively. The administration of Acv-simmondsin (0.1 g/100 g diet/day) to mice for 5 days significantly reduced food intake by 35%, compared to 25% with simmondsin in control obese mice. Acv-simmondsin (50 mg/kg BW) suppressed the postprandial blood glucose response to sucrose (1 g/kg BW) by 74%, compared to 71% with acarbose, in normal rats. Topics: Acetonitriles; alpha-Amylases; Amino Sugars; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Carbohydrate Sequence; Cyclohexanes; Eating; Glucose; Glucosides; Glycoside Hydrolase Inhibitors; Glycoside Hydrolases; Glycosylation; Hydrolysis; Hyperglycemia; Hypoglycemic Agents; Molecular Sequence Data; Postprandial Period; Rats; Rats, Sprague-Dawley; Swine; Thermus	2003

Article

Year

Acarviosine-simmondsin, a novel compound obtained from acarviosine-glucose and simmondsin by Thermus maltogenic amylase and its in vivo effect on food intake and hyperglycemia.

Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:3

Simmondsin was modified with acarviosine-glucose using the transglycosylation activity of Thermus maltogenic amylase to synthesize a novel compound with both antiobesity and hypoglycemic activity. The LC/MS and 13C NMR analyses confirmed that the structure of the major transglycosylation product was acarviosine-simmondsin (Acv-simmondsin), in which acarviosine was attached to the glucose moiety of simmondsin by an alpha-(1,6)-glycosidic linkage. It was found that Acv-simmondsin was a potent competitive inhibitor of alpha-glucosidase with the Ki value of 0.69 microM and a mixed type inhibitor of alpha-amylase with the Ki and KI of 20.78 microM and 26.31 microM, respectively. The administration of Acv-simmondsin (0.1 g/100 g diet/day) to mice for 5 days significantly reduced food intake by 35%, compared to 25% with simmondsin in control obese mice. Acv-simmondsin (50 mg/kg BW) suppressed the postprandial blood glucose response to sucrose (1 g/kg BW) by 74%, compared to 71% with acarbose, in normal rats.

Topics: Acetonitriles; alpha-Amylases; Amino Sugars; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Carbohydrate Sequence; Cyclohexanes; Eating; Glucose; Glucosides; Glycoside Hydrolase Inhibitors; Glycoside Hydrolases; Glycosylation; Hydrolysis; Hyperglycemia; Hypoglycemic Agents; Molecular Sequence Data; Postprandial Period; Rats; Rats, Sprague-Dawley; Swine; Thermus

2003