ac-7954 has been researched along with Inflammation* in 1 studies
1 other study(ies) available for ac-7954 and Inflammation
| Article | Year |
|---|---|
Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30mg/kg. 1h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-α and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation. Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Chromans; Gene Expression Regulation; Humans; Indomethacin; Inflammation; Interleukin-6; Rats; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha; Urotensins | 2016 |