ac-261066 and Adenocarcinoma

ac-261066 has been researched along with Adenocarcinoma* in 1 studies

Other Studies

1 other study(ies) available for ac-261066 and Adenocarcinoma

Article	Year
Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy. Bioorganic & medicinal chemistry, 2012, Dec-01, Volume: 20, Issue:23 Indole-3-amides and dipeptides were produced from 2-aminobenzothiazoles using the PyBop peptide coupling reagent. These analogues were tested in anti-cancer cell viability assays against SH-SY5Y neuroblastoma and MDA-MB-231 breast adenocarcinoma cell lines, and were found to exhibit cytotoxic activities at concentrations ranging from 0.1 to 20μM. These compounds were also found to act additively with a low dosage of 13-cis-retinoic acid in neuroblastoma cells. Then, using neuroblastoma cells transfected to stably overexpress the RARβ(2) gene, a SAR was developed for the indole-3-amides. Real-time PCR was also used to demonstrate their RARβ(2) agonistic activity. Topics: Adenocarcinoma; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dipeptides; Female; Humans; Indoles; Isotretinoin; Neuroblastoma; Receptors, Retinoic Acid	2012

Article

Year

Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy.

Bioorganic & medicinal chemistry, 2012, Dec-01, Volume: 20, Issue:23

Indole-3-amides and dipeptides were produced from 2-aminobenzothiazoles using the PyBop peptide coupling reagent. These analogues were tested in anti-cancer cell viability assays against SH-SY5Y neuroblastoma and MDA-MB-231 breast adenocarcinoma cell lines, and were found to exhibit cytotoxic activities at concentrations ranging from 0.1 to 20μM. These compounds were also found to act additively with a low dosage of 13-cis-retinoic acid in neuroblastoma cells. Then, using neuroblastoma cells transfected to stably overexpress the RARβ(2) gene, a SAR was developed for the indole-3-amides. Real-time PCR was also used to demonstrate their RARβ(2) agonistic activity.

Topics: Adenocarcinoma; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dipeptides; Female; Humans; Indoles; Isotretinoin; Neuroblastoma; Receptors, Retinoic Acid

2012