abyssomicin-c has been researched along with HIV-Infections* in 1 studies
1 other study(ies) available for abyssomicin-c and HIV-Infections
Article | Year |
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Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines. Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Furans; Histone Deacetylase Inhibitors; HIV Infections; HIV-1; Humans; Molecular Structure; Polyketides; Protein Kinase C; Virus Latency | 2015 |